patient_id
string
sku
string
pf_subtype
string
age_at_diagnosis
float64
sex
string
race_ethnicity
string
smoking_history
string
geographic_region
string
socioeconomic_status
string
family_history_flag
int64
familial_pf_pedigree_size
int64
upa_pattern
string
hrct_fibrosis_extent_pct
float64
honeycombing_flag
int64
traction_bronchiectasis_flag
int64
ground_glass_opacity_pct
float64
surgical_lung_biopsy_flag
int64
biopsy_histology
string
gapindex_score
int64
diagnostic_delay_months
float64
referral_to_ilds_center_flag
int64
facility_type
string
telomere_gene_mutation
string
tert_variant_class
string
telomere_length_kb
float64
telomere_short_10th_percentile_flag
int64
surfactant_protein_mutation
string
sftpc_variant
string
muc5b_promoter_rs35705950
string
muc5b_risk_allele_carrier
int64
genetic_testing_platform
string
variant_classification
string
zygosity
string
penetrance_modifier
string
fvc_pct_predicted_baseline
float64
dlco_pct_predicted_baseline
float64
tlc_pct_predicted_baseline
float64
fev1_fvc_ratio_baseline
float64
sixmwt_meters_baseline
float64
spo2_nadir_6mwt_pct
float64
resting_spo2_pct
float64
fvc_severe_flag
int64
dlco_very_severe_flag
int64
supplemental_oxygen_flag
int64
o2_flow_lpm
float64
pulmonary_hypertension_flag
int64
rvsp_mmhg
float64
fvc_annual_decline_ml_natural_history
float64
dlco_annual_decline_pct
float64
fvc_decline_category
string
fvc_quarterly_trajectory_pct
string
sixmwt_annual_decline_m
float64
echocardiogram_flag
int64
on_immunosuppression_flag
int64
infection_prophylaxis_flag
int64
pjp_prophylaxis_flag
int64
bacterial_infection_episodes_yr
int64
viral_infection_episodes_yr
int64
pjp_episode_flag
int64
aspergillus_infection_flag
int64
aspergillus_species
string
antifungal_therapy_flag
int64
antifungal_drug
string
influenza_infection_flag
int64
sars_cov2_infection_flag
int64
bacterial_pathogen
string
antibiotic_courses_yr
int64
hospitalization_for_infection_flag
int64
icu_for_infection_flag
int64
bronchoscopy_flag
int64
bal_cellular_profile
string
bronchoalveolar_lavage_neutrophil_pct
float64
bronchoalveolar_lavage_lymphocyte_pct
float64
vaccination_influenza_flag
int64
vaccination_pneumococcal_flag
int64
infection_triggered_ae_flag
int64
total_infection_episodes_yr
int64
gene_therapy_enrollment_flag
int64
gene_therapy_product
string
gene_therapy_arm
string
vector_serotype
string
delivery_route
string
vector_dose_vg_kg
float64
baseline_nab_titer_aav
float64
transduction_efficiency_pct
float64
transgene_expression_level
float64
fvc_response_month3_ml
float64
fvc_response_month6_ml
float64
dlco_response_month6_pct
float64
gt_responder_flag
float64
gt_immune_response_flag
float64
cytokine_release_syndrome_flag
float64
sae_grade345_flag
float64
gt_retreatment_flag
float64
transgene_persistence_months
float64
vector_shedding_flag
float64
aav_immunogenicity_igg_titer
float64
biomarker_sp_d_ng_ml_postgt
float64
antifibrotic_drug
string
treatment_start_months_from_dx
float64
pirfenidone_dose_mg_day
int64
nintedanib_dose_mg_day
int64
dose_reduction_flag
int64
treatment_discontinuation_flag
int64
discontinuation_reason
string
gi_adverse_events_flag
int64
gi_severity
string
photosensitivity_flag
int64
hepatotoxicity_antifib_flag
int64
nintedanib_bleeding_flag
int64
fvc_decline_on_tx_ml_yr
float64
adherence_antifibrotic_pct
float64
drug_holiday_episodes
int64
combination_therapy_flag
int64
fvc_placebo_decline_ml_yr
float64
lung_transplant_referral_flag
int64
lung_transplant_completed_flag
int64
transplant_waiting_months
float64
ipf_ae_flag
int64
ae_trigger
string
ae_severity
string
ae_icu_flag
float64
ae_mechanical_ventilation_flag
float64
ae_hospitalization_days
float64
ae_mortality_flag
float64
ae_post_event_fvc_decline_ml
float64
corticosteroid_ae_pulse_flag
float64
cyclosporine_ae_flag
float64
ae_recurrence_flag
float64
hrct_ae_pattern
string
ae_time_from_dx_months
float64
sp_d_ng_ml
float64
kl6_u_ml
float64
mmp7_ng_ml
float64
ccl18_ng_ml
float64
ca_125_u_ml
float64
periostatin_ng_ml
float64
telomere_dysfunction_foci
int64
rnaseq_tgfb1_expression
float64
rnaseq_wnt5a_expression
float64
rnaseq_spp1_expression
float64
proteomic_4marker_composite
float64
mortality_flag
int64
mortality_cause
string
time_to_mortality_months
float64
hospitalization_all_cause_flag
int64
hospitalization_days_yr
int64
gapindex_score_3yr_change
float64
disease_progression_flag
int64
quality_of_life_sf36_pcs
float64
ucsd_sobq_score
float64
eq5d_utility
float64
depression_phq9_score
float64
anxiety_gad7_score
float64
palliative_care_referral_flag
int64
end_of_life_goals_documented_flag
int64
icd11_code_pf
string
snomed_ct_code_pf
int64
loinc_code_fvc
string
loinc_code_dlco
string
omop_condition_id
int64
hpo_id_pf
string
HCGEN001-0000001
HC-GEN-001
FPF
43.68
Female
White_non_Hispanic
Ex_smoker
Other
High
1
7
UIP_Definite
36.77
0
1
12.27
0
null
7
25.68
1
Primary_Care
NAF1
null
3.29
1
null
null
TG_heterozygous
1
WES
Pathogenic
Heterozygous
Intermediate
99.12
46.31
61.85
0.83
308.59
81.05
95.6
0
0
1
3.48
0
35.26
-269.9
-4.04
Rapid
[99.12, 45.15, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-25.43
1
0
0
0
0
0
0
0
null
0
null
0
0
Haemophilus
4
0
0
0
null
null
null
1
1
0
0
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Pirfenidone
12.17
801
0
1
0
null
1
Moderate
0
0
0
-76.82
87.9
0
0
-188.74
1
0
null
1
Infection
Moderate
1
0
23
0
-220.03
1
0
0
Diffuse_alveolar_damage
16.35
14.01
50
4.16
10
25.03
5
10
5.17
2.47
2.2
10.01
0
null
null
0
15
0.57
1
39.98
79.47
0.56
4.8
3.29
0
1
CB03.10
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000002
HC-GEN-001
IPF
62.78
Female
White_non_Hispanic
Never
North_America
Middle
0
0
Non_UIP
40.94
1
1
13
0
null
0
4.27
0
Academic_ILD_Center
RTEL1
null
8.38
0
null
null
GG_wildtype
0
WGS
Benign
Heterozygous
High
56.12
81.8
58.14
0.88
366.69
85.76
90.38
0
0
1
0.5
0
24.33
-161.19
-0.5
Moderate
[56.12, 23.88, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-24.48
0
0
0
0
2
1
0
0
null
0
null
1
0
Pseudomonas_aeruginosa
2
0
0
0
null
null
null
1
1
1
3
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Pirfenidone
12.4
801
0
0
0
null
1
Mild
0
0
0
-242.74
79.66
6
0
-183.88
0
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
16.16
50
7.55
11.83
9.56
8.47
9
20
8.49
3.33
9.9
0
null
null
1
10
1.69
0
24.8
93.33
0.31
2.14
5.53
1
0
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000003
HC-GEN-001
IPF
62.55
Female
White_non_Hispanic
Ex_smoker
North_America
Low
1
0
UIP_Definite
53.63
1
1
18.63
1
UIP
2
8.2
0
Community_Pulmonology
TERT
Missense
5.67
0
null
null
TG_heterozygous
1
Targeted_panel_150gene
Pathogenic
Homozygous
High
80.91
58.36
54.67
0.88
371.2
84.49
93.61
0
0
0
0
0
30.58
-160.88
-2.58
Moderate
[80.91, 48.74, 16.56, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-36.18
1
0
0
0
1
2
0
0
null
0
null
0
0
Haemophilus
10
0
0
1
Normal
18.72
13.57
1
1
0
3
1
AAV9_TERT
Treatment
AAV9
Inhaled_nebulized
100,000,000,000
13.42
77.87
2
247.35
171.57
9.36
1
0
0
0
0
65.21
0
18.85
16.63
Pirfenidone
1.08
2,403
0
0
0
null
0
null
0
0
0
-112.8
76.88
5
0
-60
0
0
null
1
Infection
Severe
1
0
14
1
-201.37
0
1
0
Diffuse_alveolar_damage
6.74
32.32
50
7.16
14.94
18.44
10.09
5
4.02
3.66
10.74
11.34
0
null
null
0
13
-1
1
44.74
49.87
0.51
4.15
12.41
0
0
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000004
HC-GEN-001
IPF
50.19
Male
White_non_Hispanic
Never
Other
Middle
1
0
UIP_Probable
83.89
1
1
6.83
0
null
8
5.32
0
Academic_ILD_Center
RTEL1
null
7.12
0
null
null
GG_wildtype
0
Clinical_sanger
Pathogenic
Heterozygous
Intermediate
96.27
81.08
68.83
0.92
377.8
87.88
89.67
0
0
1
2.42
1
25.52
-198.46
-0.5
Moderate
[96.27, 56.57, 16.88, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-3.67
1
0
0
0
2
4
0
0
null
0
null
0
0
Haemophilus
2
1
0
1
Neutrophilic
16.37
9.74
1
1
1
6
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Neither
null
0
0
0
0
null
0
null
0
0
0
null
null
0
0
-60
0
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
32.43
50
5.76
11.47
15.75
11.2
9
6.69
2.35
11.34
10.76
0
null
null
0
5
0
1
29.53
46.93
0.62
13.74
0
1
1
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000005
HC-GEN-001
HPS_PF
47.48
Female
White_non_Hispanic
Never
North_America
Middle
0
0
UIP_Definite
57.51
1
0
14.54
0
null
4
12.34
0
Community_Pulmonology
TERT
Missense
6.53
0
null
null
TT_homozygous
1
Clinical_sanger
Likely_pathogenic
Heterozygous
Intermediate
65.98
55.67
57.2
0.85
358.54
88.18
83.36
0
0
0
0
0
25.57
-117.85
-0.5
Slow
[65.98, 42.41, 18.84, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-53.89
1
0
0
0
2
2
0
0
null
0
null
0
0
Other
5
0
0
1
Neutrophilic
16.79
3.91
1
0
1
4
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Nintedanib
0.58
0
300
0
0
null
1
Moderate
0
0
0
-164.45
74.7
0
0
-179.94
1
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
84.07
50
5.65
10.41
22.37
5
9
3.55
8.36
5.36
11.92
0
null
null
1
16
3.26
1
22.77
54.68
0.55
0
8.93
0
0
CB03.10
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000006
HC-GEN-001
IPF
67.72
Male
White_non_Hispanic
Ex_smoker
North_America
High
0
0
UIP_Probable
51.16
0
1
9.21
0
null
2
15.8
1
Academic_ILD_Center
null
null
3.71
1
null
null
TT_homozygous
1
WGS
Pathogenic
Heterozygous
Intermediate
83.69
48.57
55.63
0.92
427.48
84.67
95.59
0
0
1
0.5
0
31.93
-191.86
-5.75
Moderate
[83.69, 45.32, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-62.4
1
0
0
0
1
2
0
0
null
0
null
1
0
MRSA
2
1
1
1
Lymphocytic
29.48
6.04
0
0
1
3
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Nintedanib
4.53
0
150
0
0
null
1
Moderate
0
0
0
-75.99
84.26
6
1
-287.84
0
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
69.23
65.34
7.6
18.92
16.54
8.86
4
5.69
3.42
2.43
12.26
1
Respiratory_failure
113.23
0
17
0.5
1
31.29
32.49
0.9
12.98
11.24
0
1
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000007
HC-GEN-001
IPF
54.16
Male
White_non_Hispanic
Never
Europe
High
0
0
UIP_Definite
67.22
1
1
15.79
0
null
2
6.84
0
Primary_Care
TERT
Missense
2
1
null
null
GG_wildtype
0
WES
Likely_pathogenic
Heterozygous
Intermediate
72.94
73.86
54.47
0.91
501.34
97.02
91.66
0
0
0
0
0
42.52
-182.46
-2.92
Moderate
[72.94, 36.45, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-19.96
1
0
0
0
3
2
0
0
null
0
null
0
0
Pseudomonas_aeruginosa
1
1
0
0
null
null
null
1
1
0
5
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Nintedanib
2.54
0
300
1
0
null
0
null
0
0
0
-49.45
88.27
1
0
-275.98
1
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
17.56
50
6.82
10
27.79
6.23
5
5.97
1.54
7.95
10.74
0
null
null
0
20
0.51
1
41.57
65
0.44
3.19
9.12
1
1
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000008
HC-GEN-001
IPF
56.33
Female
Hispanic
Ex_smoker
Europe
Middle
0
0
UIP_Definite
52.14
0
1
19.41
1
RB-ILD
0
19.09
1
Community_Pulmonology
RTEL1
null
5.8
0
null
null
GG_wildtype
0
Targeted_panel_150gene
VUS
Heterozygous
High
74.16
35.73
59.45
0.85
414.68
95.7
93.52
0
1
1
3.53
1
22
-195.47
-4.76
Moderate
[74.16, 35.07, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-7.66
1
1
0
0
3
3
0
0
null
0
null
0
0
Pseudomonas_aeruginosa
2
0
0
1
Normal
29.84
11.13
1
1
0
6
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Pirfenidone
4.79
2,403
0
0
0
null
1
Mild
1
0
0
-270.68
77.43
2
0
-176.13
0
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
31.37
50
2.33
10
5.53
8.28
8
8.39
6.01
6.97
8.95
0
null
null
1
17
0.15
1
39.35
62.4
0.68
5.72
11.53
1
1
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000009
HC-GEN-001
IPF
69.55
Female
White_non_Hispanic
Never
North_America
Middle
0
0
UIP_Definite
42.51
1
0
17.02
0
null
5
13.06
0
Community_Pulmonology
RTEL1
null
5.52
0
null
null
GG_wildtype
0
Clinical_sanger
Likely_pathogenic
Heterozygous
Intermediate
81.6
69.39
81.56
0.89
439.56
77.87
89.82
0
0
1
2.43
0
30.37
-267.18
-3.7
Rapid
[81.6, 28.17, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-25.76
0
1
1
1
1
0
1
0
null
0
null
1
0
Other
4
0
0
0
null
null
null
1
0
0
1
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Nintedanib
13.56
0
300
1
0
null
1
Mild
0
0
0
-42.43
82.31
1
0
-224.49
0
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
5.64
50
3.69
10
14.48
5
4
2.67
11.34
21.35
8.58
1
Respiratory_failure
33.92
1
12
2.24
0
26.12
70.38
0.56
6.42
8.46
1
0
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000010
HC-GEN-001
IPF
75.08
Female
White_non_Hispanic
Ex_smoker
Europe
Low
0
0
UIP_Definite
50.48
1
0
13.41
0
null
8
7
0
Primary_Care
TERT
Missense
2
1
null
null
GG_wildtype
0
WGS
VUS
Heterozygous
Low
73.16
62.96
57.19
0.92
428.13
82.7
88.51
0
0
0
0
0
18.29
-168.08
-2.51
Moderate
[73.16, 39.55, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-45.44
1
1
1
1
0
3
0
0
null
0
null
0
0
Streptococcus
5
1
0
0
null
null
null
1
1
0
3
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Pirfenidone
3.64
2,403
0
0
0
null
1
Severe
0
0
0
-183.01
69.65
4
1
-121.61
0
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
39.55
50
7.58
10
16.25
18.2
11
4.96
2.67
4.59
11.1
1
Respiratory_failure
85.64
0
11
0
0
31.92
62.27
0.73
0.57
11.76
1
0
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000011
HC-GEN-001
IPF
49.37
Male
White_non_Hispanic
Ex_smoker
North_America
Low
0
0
UIP_Definite
39.74
0
1
20.59
0
null
3
16.51
0
Primary_Care
TERT
Frameshift
6.85
0
null
null
GG_wildtype
0
WGS
Benign
Heterozygous
High
77.83
78.78
73.59
0.9
347.89
91.5
86.07
0
0
1
0.5
1
22
-68.71
-0.58
Slow
[77.83, 64.09, 50.34, 36.6, 22.86, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-6.89
0
0
0
0
1
6
0
0
null
0
null
0
1
Pseudomonas_aeruginosa
2
1
0
0
null
null
null
1
1
0
7
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Pirfenidone
0.5
801
0
1
1
Hepatotoxicity
0
null
0
0
0
-86.38
93.91
0
0
-315.96
1
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
24.95
50
6.02
12.89
33.14
8.78
4
7.35
5.26
9.57
11.37
1
Infection
11.73
1
5
2.23
0
50.95
52.41
0.5
5.03
5.7
0
0
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000012
HC-GEN-001
FPF
63.74
Female
Black
Ex_smoker
North_America
Middle
1
7
Non_UIP
34.55
0
1
5.78
0
null
6
25.11
0
Academic_ILD_Center
TERT
Nonsense
3.33
1
null
null
TG_heterozygous
1
WGS
Likely_pathogenic
Homozygous
Low
78.66
40.67
78.54
0.86
378.07
82.26
88.71
0
0
1
4.98
0
25.1
-145.92
-6.86
Moderate
[78.66, 49.48, 20.3, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-40.46
1
1
1
1
2
2
0
0
null
0
null
0
0
MRSA
6
0
0
1
Neutrophilic
4.84
8.46
0
0
0
4
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Neither
null
0
0
0
0
null
0
null
0
0
0
null
null
0
0
-155.21
0
0
null
1
Infection
Critical
1
0
37
0
-334.82
0
0
1
New_bilateral_GGO
19.72
22.48
50
7.17
10
9.27
5.61
5
2.23
3.6
10.08
9.98
1
Respiratory_failure
47.98
0
9
2
0
41.11
76.41
0.73
0
0
1
1
CB03.10
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000013
HC-GEN-001
IPF
51.14
Female
White_non_Hispanic
Never
Other
Middle
0
0
Non_UIP
72.19
1
1
10.7
0
null
4
8.65
1
Academic_ILD_Center
TERT
Nonsense
6.16
0
null
null
TG_heterozygous
1
Targeted_panel_150gene
Likely_pathogenic
Heterozygous
High
67.7
62.67
82.11
0.95
411.88
92.47
88.12
0
0
0
0
0
31.9
-152.35
-0.92
Moderate
[67.7, 37.23, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-66.83
1
0
0
0
3
1
0
0
null
0
null
0
0
Other
12
0
0
0
null
null
null
1
0
1
4
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Neither
null
0
0
0
0
null
0
null
0
0
0
null
null
0
0
-192.25
0
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
44.39
50
4.65
10
7.77
5.42
6
9.37
2.41
9.47
10.12
0
null
null
1
8
1.24
1
22.36
58.67
0.49
9.18
14.61
0
0
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000014
HC-GEN-001
IPF
63.36
Female
White_non_Hispanic
Ex_smoker
North_America
High
0
0
Non_UIP
70.55
1
1
27.62
0
null
7
26.58
0
Tertiary_Hospital
RTEL1
null
4.81
0
null
null
GG_wildtype
0
WES
Pathogenic
Heterozygous
High
54.7
53.56
63.34
0.94
314.15
82.54
94.26
0
0
1
0.57
0
28.29
-227.51
-4.39
Moderate
[54.7, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-3.82
1
0
0
0
1
3
0
0
null
0
null
0
0
MRSA
2
0
0
0
null
null
null
1
1
0
4
1
AAV9_TERT
Treatment
Lentiviral
Intratracheal_instillation
100,000,000,000
30.91
25.51
6.02
115.12
77.89
-7.1
0
1
0
0
0
9.58
0
69.58
20.44
Pirfenidone
13.2
801
0
0
0
null
0
null
0
0
0
-297.78
83.59
5
0
-189.02
0
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
38.92
61
9.23
10
23.03
11.52
14
2.65
2.96
10.21
11.59
1
Respiratory_failure
30.49
0
12
0.72
1
38.1
70.82
0.79
2.41
5.46
1
1
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000015
HC-GEN-001
FPF
49.61
Male
White_non_Hispanic
Ex_smoker
North_America
High
1
8
UIP_Definite
55.23
0
0
13.03
1
UIP
7
23.99
0
Primary_Care
TERC
null
4.68
0
null
null
GG_wildtype
0
WES
Pathogenic
Heterozygous
High
60.15
53.42
43.91
0.89
426.14
92.15
89.87
0
0
0
0
1
27.3
-262.34
-7.6
Rapid
[60.15, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-18.03
1
0
0
0
0
1
0
0
null
1
null
0
0
Other
0
0
0
0
null
null
null
1
1
0
1
1
AAV5_SFTPC
Treatment
AAV9
IV_systemic
100,000,000,000
7.64
57.11
10.1
-104.11
63.5
-1.07
0
0
0
0
0
49.85
1
20.05
11.42
Pirfenidone
6.64
2,403
0
1
1
Lack_of_efficacy
1
Mild
0
0
0
-109.14
70.27
4
0
-349.26
0
0
null
1
Procedure
Moderate
1
1
21
1
-160.52
1
0
1
New_bilateral_GGO
8.44
38.94
50
7.45
20.7
21
8.74
6
4.57
2.93
3.49
11.99
1
Respiratory_failure
19.47
1
3
1
0
37.18
45.45
0.87
9.26
1.38
0
1
CB03.10
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000016
HC-GEN-001
IPF
76.89
Male
White_non_Hispanic
Current
Europe
Low
1
0
Non_UIP
67.76
0
1
9.53
0
null
1
32.04
1
Community_Pulmonology
null
null
4.31
0
null
null
TG_heterozygous
1
WGS
Likely_pathogenic
Heterozygous
Intermediate
81.95
38.09
71.54
0.85
262.77
80.03
95.64
0
1
1
0.5
0
38.95
-30
-2.43
Slow
[81.95, 75.95, 69.95, 63.95, 57.95, 51.95, 45.95, 39.95, 33.95, 27.95, 21.95, 15.95, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-15.17
0
0
0
0
3
2
0
1
terreus
1
Voriconazole
1
1
Pseudomonas_aeruginosa
1
0
0
1
Neutrophilic
10.14
7.48
1
1
0
5
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Nintedanib
14.8
0
300
0
0
null
1
Severe
0
0
0
-108.18
64.87
1
0
-101.92
0
0
null
1
Idiopathic
Moderate
1
0
36
1
-247.74
1
0
0
New_bilateral_GGO
6.24
24.12
50
20.15
10
20.31
12.52
8
18.22
2.75
7.59
11.73
0
null
null
1
18
1.69
0
60
62.1
0.7
6.18
7.51
1
0
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000017
HC-GEN-001
IPF
54.24
Female
White_non_Hispanic
Ex_smoker
Europe
Middle
0
0
UIP_Definite
55.41
1
1
14.87
1
RB-ILD
7
23.08
1
Academic_ILD_Center
RTEL1
null
9.02
0
null
null
GG_wildtype
0
WGS
Benign
Heterozygous
Low
65.17
45.44
92.13
0.93
383.13
87.04
85.57
0
0
1
1.57
0
27.12
-218.16
-3.57
Moderate
[65.17, 21.54, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-26
1
0
0
0
2
4
0
0
null
0
null
0
0
Other
3
0
0
1
Mixed
24.25
18.7
0
1
1
6
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Nintedanib
2.85
0
300
1
1
Lack_of_efficacy
1
Mild
0
0
0
-137.18
78.41
1
0
-211.57
0
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
5.89
50
7.16
10.2
20.88
11.2
10
3.94
1.32
4.4
9.53
1
Respiratory_failure
22.45
1
10
1
0
49.12
55.24
0.7
11.49
16.11
0
1
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000018
HC-GEN-001
IPF
76.41
Female
White_non_Hispanic
Never
North_America
High
0
0
UIP_Definite
66.24
1
1
11.16
1
DIP
8
14.69
0
Tertiary_Hospital
RTEL1
null
4.68
0
null
null
TG_heterozygous
1
WES
Likely_pathogenic
Heterozygous
High
84.1
52.16
39.4
0.85
464.97
80.59
86.79
0
0
1
0.5
1
30.87
-30
-1.45
Slow
[84.1, 78.1, 72.1, 66.1, 60.1, 54.1, 48.1, 42.1, 36.1, 30.1, 24.1, 18.1, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-4.91
1
0
0
0
1
3
0
0
null
0
null
0
0
Other
1
1
0
0
null
null
null
0
1
0
4
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Pirfenidone
1.5
1,602
0
1
0
null
1
Mild
0
0
0
-160.15
75.63
0
0
-261
0
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
17.99
50
4.92
10
22.97
12.8
8
1.38
4.73
1.89
10.3
0
null
null
1
10
0
0
16.65
45.36
0.8
13.55
12.43
0
1
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000019
HC-GEN-001
IPF
41.73
Female
White_non_Hispanic
Ex_smoker
North_America
Low
0
0
UIP_Definite
30.14
1
0
20.45
0
null
8
12.44
1
Primary_Care
NAF1
null
6.23
0
null
null
GG_wildtype
0
WGS
VUS
Heterozygous
High
60.13
62.77
77.83
0.86
345.1
86.54
96.98
0
0
1
0.74
1
22
-280.05
-3.52
Rapid
[60.13, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-54.16
1
1
1
1
4
7
0
0
null
0
null
0
1
Haemophilus
2
0
0
0
null
null
null
1
1
1
11
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Nintedanib
5.13
0
150
1
0
null
1
Mild
0
0
1
-26.49
84.86
6
0
-292.14
1
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
26.42
50
6.72
19.58
21.71
5
7
13.06
2.98
1.72
11.5
1
Respiratory_failure
1
1
21
0
0
36.43
73.82
0.47
10.4
8.63
0
1
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000020
HC-GEN-001
FPF
48.1
Male
White_non_Hispanic
Ex_smoker
Europe
Middle
1
4
UIP_Indeterminate
33.06
1
0
25.11
1
RB-ILD
7
17.76
1
Community_Pulmonology
TERT
Missense
6.53
0
null
null
TG_heterozygous
1
WES
VUS
Heterozygous
Intermediate
54.76
38.51
83.2
0.89
408.88
88.76
96.98
0
1
0
0
0
33.86
-153.82
-6.17
Moderate
[54.76, 24.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
0
1
0
0
0
2
1
0
0
null
0
null
0
0
Haemophilus
0
0
0
0
null
null
null
1
1
1
3
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Nintedanib
6.58
0
300
0
0
null
1
Moderate
0
0
0
-176.92
69.83
1
0
-328.69
0
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
48.62
60.56
5.67
10.12
22.92
6.46
10
4.25
2.04
3.1
11.39
1
Cardiovascular
13.8
1
11
1
0
30.56
54.63
0.72
10.25
2.97
0
1
CB03.10
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000021
HC-GEN-001
FPF
48.62
Male
White_non_Hispanic
Never
North_America
Middle
1
3
UIP_Probable
65.23
1
0
16.25
0
null
7
27.06
1
Academic_ILD_Center
TERC
null
3.51
1
null
null
TG_heterozygous
1
Targeted_panel_150gene
VUS
Heterozygous
Low
61.51
71.59
79.45
0.89
452.86
79.33
96.34
0
0
0
0
0
30.94
-173.97
-10.22
Moderate
[61.51, 26.72, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-21.35
0
0
1
1
2
2
0
0
null
0
null
0
1
MRSA
3
0
0
0
null
null
null
0
1
0
4
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Nintedanib
3.49
0
150
0
1
Hepatotoxicity
1
Mild
0
0
0
-41.09
74.31
2
1
-388.81
1
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
35.99
50
9.73
15.62
11.62
5
6
7.64
2.53
3.72
11.33
0
null
null
1
24
1
0
34.15
102.43
0.65
15.52
4.36
0
1
CB03.10
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000022
HC-GEN-001
IPF
65.94
Male
White_non_Hispanic
Ex_smoker
Asia_Pacific
Middle
0
0
Non_UIP
42.17
1
1
7.76
0
null
2
1.89
0
Community_Pulmonology
TERT
Missense
4.17
0
null
null
TG_heterozygous
1
WGS
Likely_pathogenic
Heterozygous
High
58.97
31.53
77.36
0.94
437.46
79.81
93.04
0
1
1
2.99
0
22.01
-30
-5.12
Slow
[58.97, 52.97, 46.97, 40.97, 34.97, 28.97, 22.97, 16.97, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-6.43
1
0
0
0
2
4
0
0
null
0
null
1
0
MRSA
2
0
0
0
null
null
null
1
1
0
6
1
AAV9_TERT
Placebo
AAV9
Intratracheal_instillation
100,000,000,000
1.81
61.75
1.66
-94.53
-185.31
-12.76
0
1
0
0
0
6.78
0
60.68
41.94
Nintedanib
18.18
0
150
1
0
null
1
Severe
0
0
0
-94.16
88.52
6
0
-349.99
0
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
14.62
50
5.05
10
27.4
6.59
6
4.59
5.88
6.14
10.29
0
null
null
0
7
0.93
1
26.54
43.4
0.47
1.25
5.75
1
0
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000023
HC-GEN-001
IPF
75.56
Female
White_non_Hispanic
Never
North_America
High
0
0
UIP_Definite
72.54
0
1
12.97
0
null
3
12.18
0
Community_Pulmonology
RTEL1
null
6.16
0
null
null
TG_heterozygous
1
WGS
VUS
Heterozygous
High
71.57
41.69
68.34
0.89
377.24
92.17
92.79
0
0
1
3.39
0
33.91
-237.74
-3.46
Moderate
[71.57, 24.02, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-41.42
1
0
1
1
3
2
0
0
null
0
null
0
0
Streptococcus
0
0
0
1
Neutrophilic
17.46
11.47
1
1
1
5
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Nintedanib
4.92
0
300
1
0
null
0
null
0
0
0
-175.16
55.4
1
0
-251.19
1
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
10.86
50
7.66
10.59
21.89
5
9
8.63
4.24
6.67
10.21
1
IPF_AE
37.74
1
13
1.35
1
42.71
71
0.86
7.62
5.2
0
1
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000024
HC-GEN-001
DC_PF
38.28
Male
Hispanic
Never
Asia_Pacific
Low
0
0
UIP_Definite
36.67
0
1
4.02
1
UIP
2
4.71
1
Academic_ILD_Center
TINF2
null
3.17
1
null
null
GG_wildtype
0
WES
Benign
Compound_het
High
81.54
69.33
60.02
0.85
492.92
82.06
99
0
0
0
0
0
28.87
-112.51
-0.99
Slow
[81.54, 59.04, 36.54, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-29.56
1
0
0
0
1
0
0
0
null
0
null
1
0
Pseudomonas_aeruginosa
3
1
0
0
null
null
null
0
0
0
1
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Neither
null
0
0
0
0
null
0
null
0
0
0
null
null
0
0
-298.62
1
1
3.43
1
Idiopathic
Severe
0
0
29
1
-339.67
1
0
0
New_bilateral_GGO
3.95
28.86
50
8.24
10.45
12.13
5.99
19
3.83
1.6
3.71
10.63
1
Other
16.49
1
11
2.55
1
29.12
28.04
0.48
3.09
4.11
0
1
CB03.10
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000025
HC-GEN-001
IPF
56.78
Female
Asian
Ex_smoker
Other
Middle
0
0
UIP_Probable
37.98
1
1
11.1
1
Non_specific_IP
3
19.86
1
Academic_ILD_Center
TERC
null
6.04
0
null
null
GG_wildtype
0
WES
Likely_pathogenic
Heterozygous
Low
68.28
28.74
45.87
0.92
432.32
77.28
91.2
0
1
0
0
1
40.63
-213.78
-2.05
Moderate
[68.28, 25.52, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-3.86
1
1
0
0
0
0
0
1
fumigatus
1
Isavuconazole
0
0
Other
3
1
0
1
Neutrophilic
19.4
14.31
1
0
0
0
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Nintedanib
3.32
0
300
1
1
GI_intolerance
0
null
0
0
0
-20
76.68
1
0
-133.04
1
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
28.97
50
8.82
10
22.43
9.75
8
3.44
3.58
8.89
11.24
0
null
null
0
29
2.64
0
34
45.89
0.69
12.32
6.35
0
0
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000026
HC-GEN-001
IPF
48.94
Female
White_non_Hispanic
Ex_smoker
Asia_Pacific
Middle
0
0
UIP_Indeterminate
48.48
1
1
16.17
1
Non_specific_IP
5
27.29
1
Tertiary_Hospital
NAF1
null
2.56
1
null
null
GG_wildtype
0
WES
Pathogenic
Heterozygous
High
67.97
57.88
77.91
0.95
487.09
82.85
88.92
0
0
1
0.5
0
33.29
-249.27
-2.18
Moderate
[67.97, 18.12, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-56.2
0
1
0
0
4
0
1
0
null
0
null
0
0
Pseudomonas_aeruginosa
1
1
0
0
null
null
null
1
1
1
4
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Pirfenidone
4.09
1,602
0
0
0
null
1
Moderate
0
0
0
-59.88
92.88
3
0
-269.84
0
0
null
1
Infection
Severe
1
0
14
0
-259.51
1
1
0
New_bilateral_GGO
12.44
132.78
50
8.09
13.6
42.04
11.21
2
10.4
2.8
6.52
13.55
0
null
null
1
7
1.29
0
33.16
54.32
0.27
15.31
3.62
1
1
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000027
HC-GEN-001
DC_PF
52.72
Female
White_non_Hispanic
Ex_smoker
Europe
Middle
0
0
UIP_Definite
22.69
1
1
15.86
0
null
6
23.34
1
Primary_Care
TINF2
null
4.97
0
null
null
GG_wildtype
0
Targeted_panel_150gene
Likely_pathogenic
Heterozygous
High
68.34
48.68
53.45
0.87
376.45
92.02
97.32
0
0
0
0
0
30.54
-69.23
-1.86
Slow
[68.34, 54.5, 40.65, 26.81, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-54.19
1
0
0
0
2
1
0
0
null
0
null
0
0
Streptococcus
3
1
0
1
Neutrophilic
27.91
11.88
1
0
0
3
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Nintedanib
3.51
0
300
0
0
null
0
null
0
0
0
-20
83.81
2
0
-396.89
0
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
21.61
50
8.94
10
23.54
8.55
3
4.05
6.62
19.56
11.01
1
Respiratory_failure
17.7
1
13
1.75
1
20.92
61.11
0.83
18.27
7.31
1
0
CB03.10
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000028
HC-GEN-001
IPF
54.76
Male
White_non_Hispanic
Never
Asia_Pacific
Middle
0
0
UIP_Definite
58.64
1
1
30.32
0
null
0
2
0
Academic_ILD_Center
RTEL1
null
5.13
0
null
null
TG_heterozygous
1
WGS
Pathogenic
Heterozygous
Intermediate
68.99
26.06
78.34
0.9
407.9
82.23
89.47
0
1
0
0
0
44.13
-171.3
-5.14
Moderate
[68.99, 34.73, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-1.01
1
0
0
0
2
5
0
0
null
0
null
0
0
Haemophilus
2
0
0
1
Neutrophilic
12.82
7.49
1
1
0
7
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Nintedanib
5.33
0
300
1
0
null
1
Severe
0
0
0
-219.01
85.73
1
0
-277.59
0
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
11.85
50
24.86
18.92
23.55
7.89
0
2.03
6.31
3.48
12
1
Respiratory_failure
71.81
0
14
2.43
1
36.39
65.75
0.57
7.26
7.32
1
1
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000029
HC-GEN-001
IPF
69.45
Male
White_non_Hispanic
Ex_smoker
Other
High
0
0
UIP_Definite
63.17
1
1
21.82
0
null
5
1.69
0
Community_Pulmonology
TERT
Missense
3.84
1
null
null
GG_wildtype
0
WES
VUS
Heterozygous
Intermediate
80.5
41.82
83.59
0.89
360.67
83.02
92.2
0
0
0
0
0
21.28
-210.53
-1.61
Moderate
[80.5, 38.39, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-21.33
1
1
0
0
2
1
0
1
fumigatus
1
Voriconazole
0
0
Haemophilus
2
1
1
0
null
null
null
1
1
0
3
1
AAV9_TERT
Placebo
Lentiviral
Inhaled_nebulized
100,000,000,000
6.65
26.18
4.84
-102.36
-65.89
0.64
0
0
0
0
0
14.47
1
58.41
20.43
Nintedanib
4.34
0
300
0
0
null
0
null
0
0
0
-155.53
88.03
1
0
-153.85
0
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
12.49
50
19.53
10.27
11.16
14.48
9
6.34
3.1
4.84
10.54
0
null
null
0
11
-1
0
60
70.59
0.66
6.26
7.37
1
1
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000030
HC-GEN-001
HPS_PF
40.92
Male
Asian
Current
Europe
Low
0
0
Non_UIP
57.62
1
1
17.13
1
UIP
2
5.27
0
Academic_ILD_Center
RTEL1
null
7.73
0
null
null
TG_heterozygous
1
WGS
Pathogenic
Heterozygous
Intermediate
60.8
48.33
59.29
0.94
433.34
76.41
87.53
0
0
0
0
0
33.93
-123.61
-1.81
Moderate
[60.8, 36.07, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-61.49
1
1
1
1
1
3
0
0
null
0
null
1
1
Haemophilus
1
0
0
0
null
null
null
1
1
1
4
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Pirfenidone
4.95
801
0
0
0
null
0
null
0
0
0
-28.02
73.56
1
0
-216.22
1
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
53.77
50
6.5
10.85
11.43
21.19
8
3.51
3.36
1.49
11.01
0
null
null
0
12
3.84
0
40.66
60.63
0.52
6.72
5.57
0
1
CB03.10
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000031
HC-GEN-001
IPF
53.76
Male
Hispanic
Ex_smoker
Europe
High
0
0
UIP_Probable
51.22
0
1
15.26
0
null
4
36.89
1
Tertiary_Hospital
RTEL1
null
7.3
0
null
null
GG_wildtype
0
WGS
VUS
Heterozygous
Low
65.3
73.12
79.61
0.88
264.69
76.75
89.45
0
0
0
0
0
35.81
-188.51
-2.79
Moderate
[65.3, 27.6, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-54.93
1
0
0
0
4
2
0
0
null
0
null
0
0
Haemophilus
2
0
0
1
Neutrophilic
20.31
10.56
1
1
0
6
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Nintedanib
3.83
0
300
0
0
null
0
null
0
0
0
-350
85.92
3
0
-270.21
0
0
null
1
Infection
Moderate
0
0
67
1
-544.69
1
0
1
New_bilateral_GGO
3.5
27.18
50
16.86
10
24.24
5
13
10.82
3.37
8.95
11.85
1
Respiratory_failure
12.45
0
7
1.69
1
35.26
51.15
0.65
7.64
2.79
1
0
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000032
HC-GEN-001
FPF
43.93
Male
White_non_Hispanic
Never
Europe
Middle
1
8
UIP_Probable
69.43
1
0
10.6
1
UIP
4
31.3
1
Academic_ILD_Center
TERC
null
2.21
1
null
null
TG_heterozygous
1
Clinical_sanger
VUS
Heterozygous
Low
51.64
50.68
74.04
0.91
304.97
81.52
88.72
0
0
1
0.5
0
19.4
-280.71
-2.09
Rapid
[51.64, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-26.26
1
0
0
0
1
4
0
1
fumigatus
1
Itraconazole
0
0
Haemophilus
4
1
0
1
Normal
15.13
6.04
0
1
0
5
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Nintedanib
0.58
0
300
0
1
Lack_of_efficacy
0
null
0
0
0
-70.1
66.35
3
1
-213.52
0
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
25
50
3.96
10
18.38
8.08
9
6.05
2.43
16.88
10.22
0
null
null
1
25
-0.28
0
51.6
48.35
0.74
4.64
5.09
0
1
CB03.10
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000033
HC-GEN-001
IPF
63.16
Male
White_non_Hispanic
Ex_smoker
Europe
Low
0
0
UIP_Definite
67.93
0
0
7.2
1
Non_specific_IP
2
20.84
1
Community_Pulmonology
TERT
Frameshift
6.01
0
null
null
GG_wildtype
0
Targeted_panel_150gene
VUS
Heterozygous
High
83.44
41.89
60.86
0.88
408.58
71.73
94.31
0
0
1
5.21
0
33.48
-177.29
-3.31
Moderate
[83.44, 47.98, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-14.51
1
0
0
0
2
1
1
0
null
0
null
0
0
Haemophilus
0
1
0
1
Neutrophilic
28.2
8.84
0
0
0
3
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Nintedanib
3.03
0
300
0
1
Lack_of_efficacy
1
Mild
0
0
0
-100.04
89.69
3
0
-192.41
1
0
null
1
Infection
Severe
0
1
49
0
-478.66
0
0
0
New_bilateral_GGO
6.82
19.53
50
9.07
10
36.54
8.78
13
2.35
2.09
2.68
11.35
0
null
null
1
9
-0.24
1
36.78
68.44
0.69
9.56
8.47
0
0
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000034
HC-GEN-001
IPF
50.78
Female
White_non_Hispanic
Ex_smoker
Asia_Pacific
Middle
0
0
UIP_Definite
49.62
1
1
16.96
0
null
4
52.99
1
Tertiary_Hospital
TERT
Missense
5.96
0
null
null
TT_homozygous
1
Targeted_panel_150gene
Pathogenic
Heterozygous
Low
46.84
57.69
75.08
0.93
398.03
88.29
92.79
1
0
1
2.01
0
35.23
-175.96
-3.86
Moderate
[46.84, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
0
0
1
0
0
0
1
0
0
null
0
null
0
0
MRSA
3
0
0
1
Neutrophilic
33.06
10.52
1
0
1
1
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Pirfenidone
1.79
2,403
0
0
0
null
0
null
0
0
0
-152.3
89.09
1
0
-158.13
0
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
8.64
50
7.84
10.43
17.07
12.38
3
3.89
3.65
3.7
9.78
1
IPF_AE
11.13
1
2
0.47
0
47.52
59.9
0.35
0
11.97
0
1
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000035
HC-GEN-001
IPF
58.22
Female
Asian
Ex_smoker
North_America
Middle
0
0
UIP_Indeterminate
44.88
1
1
12.56
1
UIP
7
42.62
1
Tertiary_Hospital
PARN
null
5.76
0
null
null
GG_wildtype
0
Targeted_panel_150gene
VUS
Heterozygous
High
59.84
62.65
63.76
0.87
419.75
89.04
99
0
0
1
1.21
1
40.33
-51.33
-2.7
Slow
[59.84, 49.58, 39.31, 29.05, 18.78, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-34.44
1
0
0
0
3
3
0
0
null
0
null
0
1
Streptococcus
2
0
0
1
Neutrophilic
9.23
6.71
0
1
1
6
1
AAV9_TERT
Treatment
AAVrh10
Intratracheal_instillation
100,000,000,000
11.89
57.46
3.96
252.15
34.1
9.57
0
0
0
0
0
16.06
0
35.3
13.92
Pirfenidone
11.63
1,602
0
0
1
Hepatotoxicity
1
Mild
0
0
0
-160.48
75.59
6
0
-309.77
0
0
null
1
Infection
Moderate
1
1
52
1
-37.88
0
0
1
New_bilateral_GGO
10.19
11.36
50
6.06
10
28.6
9.18
9
2.87
3.13
7.79
10.25
1
Respiratory_failure
14.12
1
22
1
0
41.8
48.73
0.5
13.55
3.47
0
0
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000036
HC-GEN-001
IPF
61.42
Male
White_non_Hispanic
Ex_smoker
North_America
High
0
0
UIP_Definite
79.71
0
1
26.1
1
UIP
1
14.24
0
Academic_ILD_Center
TERT
Missense
5.06
0
null
null
TG_heterozygous
1
Targeted_panel_150gene
VUS
Heterozygous
High
40.77
64.13
71
0.84
394.3
91.13
89.05
1
0
0
0
0
48
-150.91
-0.5
Moderate
[40.77, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-1.48
1
0
0
0
0
3
0
0
null
0
null
0
0
Pseudomonas_aeruginosa
3
0
0
0
null
null
null
1
0
1
3
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Pirfenidone
1.93
1,602
0
0
0
null
1
Moderate
0
0
0
-168.03
77.8
6
0
-142.47
1
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
17.07
50
6.47
11.32
13.55
8.11
8
4.98
1.02
22.57
10.09
0
null
null
1
9
-0.54
0
30.7
25.94
0.71
10.02
7.75
0
1
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000037
HC-GEN-001
IPF
64.57
Male
White_non_Hispanic
Ex_smoker
Europe
Middle
1
0
UIP_Definite
76.86
1
0
18.77
1
UIP
1
20.04
1
Primary_Care
TERT
Missense
3.06
1
null
null
GG_wildtype
0
WES
Likely_pathogenic
Heterozygous
High
81.05
60.1
74.28
0.86
356.34
88.65
91.6
0
0
0
0
0
30.97
-80.65
-2.03
Slow
[81.05, 64.92, 48.79, 32.66, 16.53, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-60.28
1
1
1
1
3
6
0
0
null
1
null
1
0
Pseudomonas_aeruginosa
2
0
0
0
null
null
null
1
1
1
9
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Pirfenidone
2.28
801
0
0
0
null
1
Moderate
1
0
0
-162.8
93.97
2
0
-199.79
1
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
22.27
85.17
13.36
12.7
16.24
11.45
13
2.72
3.19
1.69
11.28
1
Respiratory_failure
9.81
1
18
2.11
0
32.15
57.27
0.65
7.11
1.35
1
0
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000038
HC-GEN-001
IPF
58.8
Female
Black
Never
Europe
Middle
1
0
UIP_Probable
69.53
1
0
21.05
1
RB-ILD
1
26.15
1
Community_Pulmonology
RTEL1
null
4.74
0
null
null
GG_wildtype
0
WES
Likely_pathogenic
Heterozygous
Intermediate
42.23
57.95
58.22
0.93
522.33
88.11
91.32
1
0
1
4.51
0
37.3
-237.14
-0.9
Moderate
[42.23, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-36.81
0
0
0
0
2
0
0
0
null
0
null
1
0
Haemophilus
6
0
0
1
Neutrophilic
8.18
10.29
1
1
0
2
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Pirfenidone
3.71
801
0
0
1
Hepatotoxicity
0
null
0
0
0
-187.54
88.76
4
0
-117.31
0
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
25.58
50.6
4.75
10
11.95
8.5
7
6.86
6.37
3.06
9.99
0
null
null
1
33
1.8
1
35.73
74.36
0.9
16.03
11.17
1
1
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000039
HC-GEN-001
IPF
73.9
Female
Asian
Ex_smoker
North_America
Middle
0
0
UIP_Definite
63.5
1
1
17.46
1
UIP
6
14.74
1
Academic_ILD_Center
PARN
null
5.22
0
null
null
GG_wildtype
0
WES
Likely_pathogenic
Heterozygous
High
73.92
43.86
73.63
0.91
237.05
86.68
99
0
0
0
0
0
24.18
-44.82
-3.37
Slow
[73.92, 64.96, 55.99, 47.03, 38.06, 29.1, 20.13, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-26.97
1
0
0
0
2
2
0
0
null
0
null
0
0
Streptococcus
6
0
0
0
null
null
null
0
1
1
4
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Neither
null
0
0
0
0
null
0
null
0
0
0
null
null
0
0
-198.4
1
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
24.51
50
3.97
11.5
21.24
9.31
10
10.46
5.3
6.36
10.47
0
null
null
1
10
1.52
0
29
47.91
0.4
5.81
9.15
1
1
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000040
HC-GEN-001
HPS_PF
53.84
Male
White_non_Hispanic
Never
Europe
Middle
0
0
UIP_Indeterminate
52.86
0
1
13.31
1
UIP
7
36.31
0
Primary_Care
TERC
null
6.62
0
null
null
GG_wildtype
0
WES
Pathogenic
Compound_het
High
82.82
56.55
57.49
0.83
446.74
78.47
94.95
0
0
1
2.76
0
35.14
-102.73
-2.16
Slow
[82.82, 62.27, 41.73, 21.18, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-16.31
1
1
0
0
2
2
1
0
null
0
null
0
1
Haemophilus
8
1
0
1
Neutrophilic
21.07
12.74
0
1
1
4
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Nintedanib
9.57
0
300
1
0
null
1
Severe
0
0
0
-38.83
97.24
1
0
-297.22
0
0
null
1
Infection
Severe
1
0
47
1
-114.63
1
1
0
New_bilateral_GGO
19.62
27.46
50
7.1
10
15.8
6.25
3
10.6
4.27
5.92
10.66
1
Respiratory_failure
32.09
0
9
1
0
36.8
45.97
0.7
17.97
4.8
0
1
CB03.10
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000041
HC-GEN-001
SP_Mutation_PF
72.5
Male
White_non_Hispanic
Ex_smoker
Europe
Low
0
0
UIP_Indeterminate
72.95
1
1
6.65
0
null
7
6.19
1
Academic_ILD_Center
RTEL1
null
2.64
1
SFTPC
L188Q
GG_wildtype
0
WGS
Benign
Heterozygous
High
75.77
68.46
46.84
0.89
380.42
87.42
97.62
0
0
1
0.5
0
35.03
-112.82
-0.5
Slow
[75.77, 53.21, 30.64, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-39.77
1
0
0
0
2
0
0
0
null
0
null
0
0
Streptococcus
2
1
0
1
Lymphocytic
12.82
13.73
1
0
0
2
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Nintedanib
5.15
0
300
1
0
null
0
null
0
0
0
-81.55
65.2
1
1
-336
0
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
32.84
50
13.99
12.79
26.11
7.25
6
5.95
2.74
7.3
12.15
0
null
null
1
20
1
0
50.75
69.53
0.8
4.39
5.98
0
1
CB03.10
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000042
HC-GEN-001
IPF
72.84
Female
White_non_Hispanic
Ex_smoker
North_America
Low
0
0
UIP_Definite
42.02
1
1
14.16
0
null
5
7.6
0
Academic_ILD_Center
TERC
null
4.47
0
null
null
GG_wildtype
0
WES
Likely_pathogenic
Heterozygous
High
76.6
40.72
78.19
0.87
360.65
85.78
90.12
0
0
0
0
1
31.76
-146.43
-5.62
Moderate
[76.6, 47.32, 18.03, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-47.67
0
1
1
1
2
4
0
0
null
0
null
1
1
Pseudomonas_aeruginosa
1
0
0
0
null
null
null
0
1
1
6
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Neither
null
0
0
0
0
null
0
null
0
0
0
null
null
0
0
-308.45
0
0
null
1
Idiopathic
Severe
0
0
18
0
-219.21
0
0
1
New_bilateral_GGO
20.33
60.42
50
5.07
11.74
12.4
11.17
7
2.47
3.43
6.82
11.06
1
Infection
17.18
1
16
3
0
43.7
61.81
0.67
9.15
8.88
1
1
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000043
HC-GEN-001
SP_Mutation_PF
79.51
Female
White_non_Hispanic
Ex_smoker
Asia_Pacific
High
1
0
UIP_Probable
80.88
1
0
32.51
0
null
7
33.82
1
Community_Pulmonology
TERT
Missense
6.25
0
SFTPA1
null
GG_wildtype
0
WGS
Benign
Compound_het
Intermediate
44.28
40.16
48.88
0.93
431.09
82.71
92.31
1
0
1
9.75
0
33.01
-144.69
-2.69
Moderate
[44.28, 15.34, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-33.82
1
0
0
0
2
2
0
0
null
0
null
0
0
Haemophilus
2
0
0
0
null
null
null
0
1
1
4
1
AAV5_SFTPC
Treatment
AAV9
Inhaled_nebulized
100,000,000,000
18.01
79.18
1.66
54.35
280.24
7.85
1
0
0
0
0
31.33
0
20.15
30.58
Pirfenidone
1.53
2,403
0
0
1
GI_intolerance
1
Moderate
0
0
0
-62.23
82.54
5
0
-286.63
1
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
25.01
65.72
6.83
10
6.49
9.79
11
1.54
5.85
10.34
9.73
0
null
null
1
18
1
1
40.92
75.11
0.72
7.06
8.29
1
0
CB03.10
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000044
HC-GEN-001
IPF
59.04
Female
White_non_Hispanic
Ex_smoker
Asia_Pacific
Middle
0
0
UIP_Probable
69.4
1
1
10.81
0
null
7
9.38
1
Academic_ILD_Center
PARN
null
6.16
0
null
null
GG_wildtype
0
WGS
VUS
Heterozygous
Low
60.36
67.75
56.08
0.91
314.07
88.46
91.12
0
0
0
0
0
38.71
-199.87
-3.99
Moderate
[60.36, 20.39, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-49.15
1
1
0
0
2
2
0
0
null
0
null
1
0
Streptococcus
3
0
0
1
Lymphocytic
22.25
7.46
1
1
0
4
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Pirfenidone
5.1
1,602
0
1
0
null
0
null
0
0
0
-253.64
71.51
6
0
-110.05
0
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
13.17
50
4.93
10
14.24
13.87
10
15.04
3.63
25
9.55
1
Respiratory_failure
8.31
1
11
1
0
55.98
76.36
0.58
10.17
8.82
1
0
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000045
HC-GEN-001
SP_Mutation_PF
59.47
Male
White_non_Hispanic
Ex_smoker
North_America
Middle
0
0
UIP_Definite
67.8
1
1
16.28
1
UIP
7
33.29
1
Academic_ILD_Center
TERT
Missense
6.81
0
SFTPC
I73T
TG_heterozygous
1
Targeted_panel_150gene
Likely_pathogenic
Heterozygous
High
49.58
36.3
77.17
0.94
436.37
69.33
97.9
1
1
1
0.5
1
43.26
-30
-7.97
Slow
[49.58, 43.58, 37.58, 31.58, 25.58, 19.58, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-12.7
1
1
1
1
1
3
0
0
null
0
null
1
0
Haemophilus
0
0
0
1
Mixed
11.59
7.5
1
1
1
4
1
AAV9_TERT
Treatment
AAV6
Inhaled_nebulized
100,000,000,000
10.15
39.62
4.86
-21.28
-85.78
5.57
0
1
0
0
0
69.76
0
82
5
Nintedanib
17.92
0
300
1
0
null
1
Mild
0
1
1
-203.75
92.11
2
0
-244.1
0
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
11.22
50
3.43
13.46
17.19
6.31
11
1.2
3.95
18.8
9.56
1
Respiratory_failure
3.44
1
7
1
1
25.9
30.79
0.62
12.15
6.37
0
1
CB03.10
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000046
HC-GEN-001
IPF
84.89
Male
White_non_Hispanic
Ex_smoker
North_America
Low
0
0
UIP_Definite
77.64
0
1
16.62
0
null
3
13.44
1
Academic_ILD_Center
RTEL1
null
5.72
0
null
null
GG_wildtype
0
WGS
Likely_pathogenic
Heterozygous
Intermediate
45.26
40.63
41.57
0.93
446.08
90.27
99
1
0
0
0
0
24.26
-201.8
-4.29
Moderate
[45.26, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-17.78
1
0
0
0
2
1
0
0
null
0
null
0
1
Haemophilus
0
1
0
0
null
null
null
0
1
0
3
1
AAV6_SFTPC
Treatment
AAV6
Inhaled_nebulized
100,000,000,000
5.79
32.1
8.06
61.81
100.15
5.24
1
1
0
0
0
34.93
0
39
43.32
Neither
null
0
0
0
0
null
0
null
0
0
0
null
null
0
0
-201.24
0
0
null
1
Infection
Severe
0
1
11
1
-400.22
1
0
0
New_bilateral_GGO
16.12
19.83
50
10.96
12.36
11.96
8.41
6
11.81
4.36
9.67
10.67
1
Respiratory_failure
59.15
1
3
2.21
0
38.31
8.07
0.42
6.09
11.04
0
0
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000047
HC-GEN-001
DC_PF
62.14
Male
White_non_Hispanic
Current
Europe
Middle
0
0
UIP_Probable
40.93
1
1
6.39
0
null
1
16.04
1
Tertiary_Hospital
TINF2
null
2.87
1
null
null
TG_heterozygous
1
WES
VUS
Homozygous
High
85.2
65.91
70.5
0.9
456.85
81.84
98.94
0
0
0
0
0
36.55
-173.09
-3.83
Moderate
[85.2, 50.58, 15.96, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-28.66
0
1
1
1
2
3
0
0
null
0
null
0
1
Haemophilus
4
0
0
1
Normal
10.62
10.24
1
0
1
5
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Pirfenidone
1.33
1,602
0
1
0
null
1
Mild
0
0
0
-140.43
68.51
5
0
-60
0
0
null
1
Idiopathic
Severe
0
0
31
1
-363.88
0
0
0
New_bilateral_GGO
16.23
17.53
72.62
4.67
10.02
9.59
12.14
16
1.56
2.79
14.66
9.41
0
null
null
0
28
3.91
1
37.44
45.42
0.75
8.51
4.99
1
0
CB03.10
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000048
HC-GEN-001
IPF
60.65
Female
White_non_Hispanic
Never
North_America
Middle
0
0
UIP_Definite
53.17
0
0
11.73
0
null
4
27.27
1
Academic_ILD_Center
PARN
null
5.89
0
null
null
GG_wildtype
0
Targeted_panel_150gene
VUS
Heterozygous
High
79.11
62.28
81.76
0.81
382.95
82.86
91.61
0
0
0
0
0
26.35
-46.13
-1.89
Slow
[79.11, 69.88, 60.66, 51.43, 42.2, 32.98, 23.75, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
0
1
0
0
0
1
4
0
0
null
0
null
0
0
Other
2
0
0
1
Lymphocytic
30.74
12.85
0
0
0
5
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Nintedanib
6.04
0
300
0
0
null
0
null
0
0
0
-216.2
75.14
3
0
-488.9
0
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
59.84
53.64
3.79
18.12
14.42
5.69
9
3.97
7.17
7.68
11.36
1
IPF_AE
7.52
0
22
3.87
0
37.93
46.84
0.74
9.66
6.91
0
1
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000049
HC-GEN-001
DC_PF
41.25
Female
White_non_Hispanic
Never
Europe
Low
0
0
UIP_Probable
36.4
0
1
26.38
0
null
0
4.01
1
Academic_ILD_Center
TERT
Frameshift
5.87
0
null
null
GG_wildtype
0
WES
Likely_pathogenic
Heterozygous
Intermediate
55.46
66.15
62.96
0.87
376.54
91.21
94.8
0
0
0
0
1
49.76
-30
-1.61
Slow
[55.46, 49.46, 43.46, 37.46, 31.46, 25.46, 19.46, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-24.41
1
0
0
0
2
5
0
0
null
0
null
0
0
Streptococcus
4
0
0
0
null
null
null
1
1
0
7
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Nintedanib
4.14
0
300
0
0
null
1
Mild
0
0
0
-133.36
83.56
5
0
-297.48
1
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
18.69
50
6.66
10
20.71
6.82
13
6.39
5.96
2.98
10.49
1
Respiratory_failure
49.75
1
16
2.5
1
23.57
63.81
0.38
7.29
5.54
0
1
CB03.10
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000050
HC-GEN-001
FPF
52.3
Male
White_non_Hispanic
Ex_smoker
Europe
High
1
4
UIP_Probable
68.69
0
1
16.02
0
null
4
12.23
1
Community_Pulmonology
RTEL1
null
3.73
1
null
null
TG_heterozygous
1
WES
Pathogenic
Heterozygous
Intermediate
83.56
43.74
66.32
0.78
319.86
85.31
95.04
0
0
0
0
1
23.83
-179.49
-5.22
Moderate
[83.56, 47.66, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-37.98
1
1
0
0
5
2
0
0
null
0
null
0
1
Other
1
0
0
0
null
null
null
1
0
0
7
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Nintedanib
3.45
0
300
0
0
null
1
Mild
0
0
0
-144.64
95.92
2
0
-248.05
0
0
null
1
Drug
Critical
1
0
26
1
-56
1
0
0
New_bilateral_GGO
7.51
18.19
50
5.79
10
13.98
11.94
5
12.69
1.71
18.74
9.97
1
Respiratory_failure
2.68
1
11
2.02
0
29.08
34.37
0.86
15.58
11.49
1
1
CB03.10
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000051
HC-GEN-001
IPF
41.83
Female
White_non_Hispanic
Ex_smoker
Other
Middle
0
0
UIP_Probable
31.26
0
0
5.5
0
null
0
34.77
1
Tertiary_Hospital
TERT
Missense
5.17
0
null
null
GG_wildtype
0
WES
Likely_pathogenic
Heterozygous
High
66.04
58.84
62.55
0.81
347.04
84.2
98.53
0
0
0
0
0
43.23
-178.81
-0.5
Moderate
[66.04, 30.28, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-58.76
1
0
0
0
5
2
0
0
null
0
null
0
0
Other
1
1
0
0
null
null
null
1
1
0
7
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Pirfenidone
0.58
2,403
0
0
1
Lack_of_efficacy
1
Moderate
0
0
0
-63.88
85.91
5
0
-211.48
1
1
3.9
0
null
null
null
null
null
null
null
null
null
null
null
null
16.95
50
4.04
28.17
27.93
9.11
13
1.37
0.92
4.57
11.24
0
null
null
1
18
1.82
0
33.32
79.9
0.74
7.7
5.69
1
0
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000052
HC-GEN-001
SP_Mutation_PF
35
Male
White_non_Hispanic
Ex_smoker
Europe
Middle
0
0
UIP_Probable
66.74
1
1
9.54
0
null
1
6.78
1
Academic_ILD_Center
null
null
7.16
0
SFTPC
L188Q
GG_wildtype
0
WGS
Benign
Heterozygous
High
59.7
52.01
69.45
0.82
360.9
86.97
92.5
0
0
1
2.47
0
25.69
-204.96
-6.1
Moderate
[59.7, 18.71, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-7.29
1
1
1
1
3
3
0
0
null
0
null
0
0
MRSA
6
0
0
1
Neutrophilic
15.73
4.48
1
1
1
6
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Nintedanib
15.78
0
300
0
0
null
1
Moderate
0
0
0
-99.41
67.57
4
0
-162.16
0
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
43.41
50
6.03
10.84
13.89
10.47
5
4
1.02
20.21
10.92
1
Respiratory_failure
42.17
0
30
2.05
0
27.48
49.8
0.48
16.05
4.76
1
0
CB03.10
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000053
HC-GEN-001
IPF
69.04
Female
Asian
Ex_smoker
Europe
Low
0
0
UIP_Definite
44.12
1
1
23.11
0
null
7
22.39
1
Academic_ILD_Center
TERC
null
4.88
0
null
null
TG_heterozygous
1
WGS
VUS
Heterozygous
High
57.08
72.69
73.86
0.87
328.97
90.6
93.17
0
0
0
0
0
33.18
-195.98
-2.14
Moderate
[57.08, 17.88, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-31.97
1
0
0
0
3
3
0
0
null
0
null
1
0
Pseudomonas_aeruginosa
3
1
0
0
null
null
null
0
1
0
6
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Nintedanib
6.05
0
300
0
0
null
0
null
0
0
0
-95.1
87.62
3
0
-451.48
0
0
null
1
Infection
Critical
0
1
33
0
-375.29
1
0
0
New_bilateral_GGO
21.97
17.67
50
12.43
10
16.08
7.63
10
9.43
1.71
9.01
10.76
1
Respiratory_failure
8.95
0
9
1
1
39.67
28.11
0.79
0.95
9.43
0
1
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000054
HC-GEN-001
FPF
51.55
Male
White_non_Hispanic
Ex_smoker
North_America
High
1
7
UIP_Definite
59.75
1
1
8.26
0
null
1
40.26
0
Academic_ILD_Center
TINF2
null
4.32
0
null
null
TG_heterozygous
1
WES
Pathogenic
Homozygous
High
79.76
54.97
71.02
0.9
344.63
88.03
93.09
0
0
1
1.42
0
23.8
-50
-4.78
Slow
[79.76, 69.76, 59.76, 49.76, 39.76, 29.76, 19.76, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-29.78
1
1
0
0
2
2
0
0
null
0
null
0
0
Pseudomonas_aeruginosa
8
1
0
1
Neutrophilic
23.25
15.98
1
1
1
4
1
AAV6_SFTPC
Placebo
AAVrh10
IV_systemic
100,000,000,000
2.86
56.84
3.49
-7.45
-211.77
2.09
0
0
0
0
0
1.8
0
65.43
49.52
Pirfenidone
2.55
1,602
0
1
1
GI_intolerance
1
Mild
0
0
0
-241.56
89.31
4
0
-244.62
1
0
null
1
Idiopathic
Moderate
0
0
48
0
-360.99
1
0
0
New_bilateral_GGO
7.31
34.46
50
3.22
13.25
9.89
6.45
17
3.85
2.29
13.56
10.05
1
Infection
79.9
1
5
1.57
0
30.28
59.87
0.62
4.92
7.66
1
0
CB03.10
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000055
HC-GEN-001
IPF
64.55
Male
White_non_Hispanic
Current
Other
High
0
0
UIP_Indeterminate
46.02
1
1
9.47
0
null
5
47.3
0
Community_Pulmonology
RTEL1
null
7.7
0
null
null
GG_wildtype
0
WGS
VUS
Heterozygous
Intermediate
100
46.89
91.67
0.83
338.78
79.8
88.08
0
0
0
0
0
32.31
-130.5
-7.1
Moderate
[100.0, 73.9, 47.8, 21.7, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
0
1
1
1
1
3
3
0
0
null
0
null
0
1
Pseudomonas_aeruginosa
2
0
0
0
null
null
null
1
1
0
6
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Neither
null
0
0
0
0
null
0
null
0
0
0
null
null
0
0
-336.13
1
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
23.53
50
6.96
10
28.37
7.65
11
5.06
1.65
5.68
11.05
0
null
null
0
7
3
0
29.8
105.48
0.7
9.2
10.24
0
1
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000056
HC-GEN-001
IPF
47.5
Female
White_non_Hispanic
Ex_smoker
Asia_Pacific
High
0
0
UIP_Definite
60.35
0
1
16.79
0
null
8
10.12
0
Academic_ILD_Center
TERT
Missense
7.31
0
null
null
GG_wildtype
0
Clinical_sanger
Pathogenic
Heterozygous
Intermediate
83.34
54.96
82.97
0.89
352.23
88.03
98.88
0
0
0
0
0
31.69
-146.93
-3.52
Moderate
[83.34, 53.95, 24.57, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-4.92
1
0
0
0
1
4
0
0
null
0
null
0
0
Pseudomonas_aeruginosa
7
0
0
0
null
null
null
0
0
0
5
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Neither
null
0
0
0
0
null
0
null
0
0
0
null
null
0
0
-214.11
0
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
43.02
50
5.07
10.78
18.45
6.11
1
2.77
2.28
3.52
11.02
1
Respiratory_failure
10.34
1
20
0
0
14.26
61.8
0.76
5.7
8.68
0
0
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000057
HC-GEN-001
FPF
46.77
Male
Black
Ex_smoker
North_America
High
1
7
UIP_Definite
54.77
0
1
5.63
0
null
0
3.76
1
Community_Pulmonology
TERC
null
4.7
0
null
null
GG_wildtype
0
Targeted_panel_150gene
Likely_pathogenic
Heterozygous
Intermediate
73.21
43.47
58.31
0.93
402.63
93.6
95.22
0
0
1
0.5
0
34.72
-211.27
-4.89
Moderate
[73.21, 30.95, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-30.25
1
0
0
0
2
1
0
0
null
0
null
0
0
Pseudomonas_aeruginosa
7
1
0
0
null
null
null
1
1
0
3
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Pirfenidone
8.33
1,602
0
1
1
Lack_of_efficacy
1
Mild
1
0
0
-151.68
90.54
3
0
-314.03
1
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
21.9
50
11.18
10
13.59
6.73
12
4.37
8.15
9.62
10.71
0
null
null
1
12
1.14
1
34.28
55.6
0.56
3.65
4.83
0
1
CB03.10
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000058
HC-GEN-001
FPF
59.41
Male
Black
Never
Europe
Low
1
6
UIP_Definite
82.04
1
1
13.07
0
null
1
4.71
0
Tertiary_Hospital
TINF2
null
2.86
1
null
null
TG_heterozygous
1
WGS
Pathogenic
Heterozygous
High
81.23
43.48
82.15
0.9
174.2
84.19
93.36
0
0
0
0
0
25.03
-260.72
-6.31
Rapid
[81.23, 29.09, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-40.4
1
0
0
0
1
5
0
0
null
0
null
0
0
Pseudomonas_aeruginosa
6
0
0
1
Lymphocytic
22.57
2.26
1
1
1
6
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Nintedanib
9.75
0
300
1
0
null
1
Mild
0
0
0
-294.58
88.88
2
0
-182.36
0
0
null
1
Idiopathic
Severe
0
1
63
1
-289.71
1
0
1
Diffuse_alveolar_damage
24.38
12.56
97.04
5.99
14
13.91
7.09
6
1.77
3.06
4.55
9.96
0
null
null
0
6
0.15
1
45.74
32.31
0.64
3.33
3.1
0
0
CB03.10
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000059
HC-GEN-001
IPF
71.49
Female
White_non_Hispanic
Ex_smoker
North_America
Middle
0
0
UIP_Probable
35.24
0
1
27.52
0
null
3
18.49
0
Community_Pulmonology
RTEL1
null
4.79
0
null
null
TT_homozygous
1
Targeted_panel_150gene
Likely_pathogenic
Heterozygous
High
81.93
60.07
72.75
0.84
560.05
75.84
91.45
0
0
0
0
0
32.08
-193.73
-1.04
Moderate
[81.93, 43.18, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-52.23
1
0
0
0
3
3
0
0
null
0
null
0
0
Haemophilus
2
1
0
0
null
null
null
1
1
1
6
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Pirfenidone
3.15
2,403
0
1
0
null
1
Mild
1
0
0
-20
70.81
2
0
-180.39
1
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
35.07
50
6.17
10
9.5
6.75
5
4.81
4.44
25
10.3
1
Infection
32.68
1
15
2.69
1
36.72
28.98
0.76
0.86
13.58
1
1
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000060
HC-GEN-001
HPS_PF
28.33
Male
White_non_Hispanic
Ex_smoker
Asia_Pacific
Middle
0
0
UIP_Indeterminate
57.14
1
1
23.58
0
null
4
6.92
1
Primary_Care
RTEL1
null
6.58
0
null
null
GG_wildtype
0
WGS
VUS
Heterozygous
Intermediate
72.37
54.05
67.13
0.9
325.27
98
87.36
0
0
0
0
0
44.24
-280.61
-2.31
Rapid
[72.37, 16.25, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-22.54
1
0
0
0
1
0
0
0
null
0
null
0
0
Streptococcus
1
0
0
0
null
null
null
1
1
1
1
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Nintedanib
8.51
0
150
1
0
null
1
Severe
0
0
0
-85.22
83.45
3
0
-366.47
0
0
null
1
Drug
Moderate
0
0
37
1
-147.67
1
1
0
New_bilateral_GGO
16.77
52.36
70.87
13.33
10
10.21
13.61
10
5.46
2.42
8.15
11.45
0
null
null
0
23
2.04
0
30.18
53.93
0.87
2.02
6.21
0
1
CB03.10
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000061
HC-GEN-001
IPF
69.57
Female
White_non_Hispanic
Ex_smoker
Europe
High
0
0
UIP_Definite
42.95
1
1
31.05
0
null
1
4.59
0
Tertiary_Hospital
TERC
null
3.72
1
null
null
GG_wildtype
0
WES
Pathogenic
Heterozygous
High
59.98
59.59
54.66
0.85
334.73
81.23
98.44
0
0
1
3.51
0
37.16
-230.02
-4.91
Moderate
[59.98, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-32.62
1
0
0
0
2
2
0
0
null
0
null
0
0
Haemophilus
0
0
0
0
null
null
null
0
1
0
4
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Nintedanib
1.72
0
150
1
1
AE_other
0
null
0
0
0
-20
94.51
2
0
-303.36
0
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
32.82
50
4.75
10.34
14.91
17.02
9
1.7
4.09
8.86
10.47
0
null
null
0
31
2.52
1
43.05
44.94
0.73
2.83
7.21
1
0
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000062
HC-GEN-001
HPS_PF
36.81
Female
White_non_Hispanic
Never
Asia_Pacific
Middle
0
0
UIP_Definite
69.48
0
0
6.51
0
null
3
47.96
1
Community_Pulmonology
PARN
null
6.24
0
null
null
GG_wildtype
0
WES
Pathogenic
Heterozygous
Low
70.72
53.1
66.04
0.88
396.86
78.93
89
0
0
1
0.87
1
25.94
-157.05
-5.59
Moderate
[70.72, 39.31, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
0
1
0
0
0
0
8
0
0
null
0
null
0
0
Streptococcus
0
1
0
0
null
null
null
1
1
0
8
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Pirfenidone
8.41
1,602
0
0
0
null
0
null
1
0
0
-215.53
83.36
6
0
-218.03
0
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
23.48
50
5.17
10
28.67
6.43
10
5.41
1.65
8.7
10.81
0
null
null
1
11
-0.43
0
32.91
64.79
0.73
2.06
15.98
1
0
CB03.10
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000063
HC-GEN-001
IPF
64.15
Male
White_non_Hispanic
Ex_smoker
Other
Middle
0
0
UIP_Probable
38.27
0
0
6.58
0
null
5
9.58
0
Academic_ILD_Center
TERT
Splice_site
8.95
0
null
null
TG_heterozygous
1
WES
VUS
Heterozygous
Intermediate
70.56
51.82
61.17
0.92
339.92
86.76
98.54
0
0
1
2.67
0
29.18
-172.78
-0.5
Moderate
[70.56, 36.01, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-71.12
1
0
0
0
2
2
0
0
null
0
null
0
0
Haemophilus
3
0
0
1
Neutrophilic
17.74
10.72
1
0
0
4
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Pirfenidone
2.43
801
0
1
0
null
0
null
0
0
0
-134.61
85.07
0
0
-214.63
0
0
null
1
Idiopathic
Critical
1
0
56
1
-240.44
1
0
0
New_bilateral_GGO
7.87
81.93
56.42
5.18
10
21.17
7.31
9
7
2.5
2.77
11.74
0
null
null
1
19
2.53
0
27.49
55.28
0.77
15.51
7.82
0
0
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000064
HC-GEN-001
HPS_PF
32.13
Male
Hispanic
Ex_smoker
North_America
High
0
0
UIP_Definite
65.08
1
1
20.16
1
UIP
4
14.7
1
Academic_ILD_Center
TERT
Missense
2.59
1
null
null
GG_wildtype
0
WGS
VUS
Heterozygous
High
62.22
35.58
63.56
0.85
211.21
86.02
93.38
0
1
0
0
0
26.49
-175.59
-4.13
Moderate
[62.22, 27.11, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
0
1
1
1
1
3
2
0
1
fumigatus
1
Isavuconazole
0
0
Other
4
1
0
1
Neutrophilic
29.13
13.46
0
1
1
5
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Neither
null
0
0
0
0
null
0
null
0
0
0
null
null
0
0
-223.2
0
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
15.97
50
8.39
10
9.92
5
10
1.52
3.37
19.06
9.86
1
Respiratory_failure
37.95
1
7
1.56
1
36.43
55.4
0.74
12.13
4.78
0
0
CB03.10
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000065
HC-GEN-001
SP_Mutation_PF
83.05
Female
Asian
Ex_smoker
Asia_Pacific
High
0
0
UIP_Indeterminate
59.97
0
0
23.27
1
UIP
4
17.65
1
Academic_ILD_Center
RTEL1
null
7.89
0
SFTPC
Other_missense
TG_heterozygous
1
WGS
Pathogenic
Heterozygous
Low
55.91
64.32
88.78
0.86
368.86
89.34
91.17
0
0
1
1.81
0
32.18
-273.85
-5.71
Rapid
[55.91, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-24.94
0
0
1
1
1
3
0
1
niger
1
Voriconazole
0
0
MRSA
2
0
0
1
Neutrophilic
8.44
9.43
1
1
1
4
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Pirfenidone
4.13
2,403
0
0
0
null
0
null
1
0
0
-27.79
88.26
0
0
-292.2
0
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
34.59
50
5.12
10
12.36
13.08
8
2.88
6.16
4.02
10.37
0
null
null
0
14
1.41
0
44.32
78.6
0.75
7.89
8.12
0
0
CB03.10
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000066
HC-GEN-001
FPF
58.32
Female
White_non_Hispanic
Ex_smoker
North_America
Middle
1
5
Non_UIP
31.43
1
1
3.12
0
null
2
5.95
1
Academic_ILD_Center
NAF1
null
2.97
1
null
null
GG_wildtype
0
WES
VUS
Heterozygous
High
71.1
58.09
69.58
0.9
362.74
77.02
86.28
0
0
0
0
1
22
-182.99
-4.23
Moderate
[71.1, 34.51, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-29.42
1
1
1
1
5
3
1
0
null
0
null
0
0
Pseudomonas_aeruginosa
8
0
0
0
null
null
null
1
0
0
8
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Nintedanib
0.5
0
300
1
0
null
1
Moderate
0
0
0
-112.65
81.37
1
0
-99.03
1
1
7.27
0
null
null
null
null
null
null
null
null
null
null
null
null
9.95
50
2.47
10
12.33
11.26
13
8.69
3.08
1.11
8.63
1
Cardiovascular
57.9
0
6
2.35
0
27.69
91.85
0.53
5.44
12.79
1
1
CB03.10
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000067
HC-GEN-001
IPF
63.79
Male
White_non_Hispanic
Never
Europe
Middle
0
0
UIP_Definite
40.59
1
1
13.04
0
null
1
23.6
0
Tertiary_Hospital
TERT
Missense
7.54
0
null
null
TG_heterozygous
1
Clinical_sanger
Likely_pathogenic
Heterozygous
Intermediate
75.48
74.75
70.27
0.92
446.33
76.72
87.89
0
0
0
0
0
31.05
-129.39
-2.07
Moderate
[75.48, 49.6, 23.72, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-32.74
1
0
0
0
1
3
0
0
null
0
null
0
0
Pseudomonas_aeruginosa
7
0
0
0
null
null
null
1
1
0
4
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Neither
null
0
0
0
0
null
0
null
0
0
0
null
null
0
0
-144.35
0
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
33.3
50
2.38
16.7
15.03
5
7
5.58
3.19
2.04
10.4
0
null
null
1
13
-0.78
1
41.3
78.11
0.72
11.68
0
1
0
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000068
HC-GEN-001
IPF
73.96
Male
Hispanic
Current
North_America
Low
0
0
UIP_Definite
19.17
1
0
6.69
0
null
8
26.62
0
Community_Pulmonology
TERT
Frameshift
5.94
0
null
null
GG_wildtype
0
WGS
Pathogenic
Heterozygous
Intermediate
74.88
41.88
72.75
0.9
501.38
93.06
96.06
0
0
0
0
0
40.22
-254.3
-4.39
Rapid
[74.88, 24.02, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-15.65
0
1
1
1
4
2
0
0
null
0
null
0
0
Pseudomonas_aeruginosa
2
0
0
1
Neutrophilic
32.81
10.57
1
1
1
6
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Neither
null
0
0
0
0
null
0
null
0
0
0
null
null
0
0
-299.87
1
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
75.53
50
7.94
10
12.25
5
2
2.17
3.64
12.85
11.51
0
null
null
0
4
0
0
30.55
62.57
0.68
10.72
10.33
0
1
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000069
HC-GEN-001
IPF
56.27
Female
White_non_Hispanic
Ex_smoker
North_America
Middle
0
0
UIP_Indeterminate
64.49
1
1
18.54
0
null
8
30.35
0
Academic_ILD_Center
PARN
null
5.01
0
null
null
TG_heterozygous
1
Targeted_panel_150gene
VUS
Heterozygous
Low
72.53
67.16
75.15
0.88
388.14
84.92
88.67
0
0
0
0
0
33.2
-166.12
-0.5
Moderate
[72.53, 39.31, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-41.74
0
0
0
0
1
1
0
0
null
0
null
0
0
Haemophilus
1
0
0
0
null
null
null
1
1
0
2
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Nintedanib
16.39
0
150
0
0
null
0
null
0
0
0
-176.25
71.02
6
0
-79.21
1
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
13
50
4.14
10
40.52
6.78
7
2.55
5.89
0.62
10.4
0
null
null
1
10
0
0
27.06
40.29
0.45
17.87
0
0
1
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000070
HC-GEN-001
HPS_PF
52.16
Male
White_non_Hispanic
Ex_smoker
North_America
Middle
0
0
UIP_Indeterminate
53.41
1
1
8.81
1
UIP
5
3.47
1
Primary_Care
RTEL1
null
5.28
0
null
null
TG_heterozygous
1
Targeted_panel_150gene
Benign
Heterozygous
Low
66.12
36.12
67.53
0.92
353.03
92.62
92.28
0
1
0
0
1
28.21
-276.54
-6.03
Rapid
[66.12, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-16.4
1
0
0
0
1
3
0
1
fumigatus
1
Voriconazole
0
0
Pseudomonas_aeruginosa
2
0
0
0
null
null
null
1
1
1
4
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Nintedanib
0.7
0
150
1
0
null
0
null
0
0
0
-75.96
89.98
1
0
-75.65
0
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
8.03
50
5.08
10
17.77
6.76
11
1.4
3.45
3.27
9.34
1
Respiratory_failure
20.4
0
12
0.88
0
35.5
44
0.82
2.87
5.25
0
0
CB03.10
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000071
HC-GEN-001
IPF
59.94
Male
White_non_Hispanic
Ex_smoker
North_America
Middle
1
0
UIP_Definite
55.6
1
0
14.25
0
null
0
15.18
1
Academic_ILD_Center
TERT
Frameshift
5.69
0
null
null
GG_wildtype
0
WGS
VUS
Heterozygous
High
72.78
51.06
64.3
0.9
391.15
98
89.15
0
0
1
0.5
1
22.28
-104.28
-4.32
Slow
[72.78, 51.93, 31.07, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-13.61
0
0
0
0
1
5
0
0
null
1
null
0
0
Haemophilus
2
0
0
0
null
null
null
1
1
1
6
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Nintedanib
28.27
0
300
0
0
null
0
null
0
0
0
-205.97
79.81
2
1
-356.45
0
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
28.35
50
5.04
10
10.56
9.82
7
15.62
6.2
15.13
10.02
0
null
null
1
27
2.11
1
53.66
29.19
0.91
0
9.61
0
1
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000072
HC-GEN-001
IPF
58.28
Male
White_non_Hispanic
Ex_smoker
North_America
High
0
0
UIP_Definite
62.37
0
0
14.21
0
null
7
8.61
1
Tertiary_Hospital
TERT
Frameshift
7.13
0
null
null
GG_wildtype
0
WES
VUS
Heterozygous
High
66.85
65.07
64.58
0.85
290.13
95.74
91.83
0
0
1
2.56
0
32.61
-167.01
-4.05
Moderate
[66.85, 33.44, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-40.65
0
0
0
0
2
3
0
0
null
0
null
0
1
Pseudomonas_aeruginosa
2
0
0
1
Lymphocytic
10.45
4.73
1
0
0
5
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Pirfenidone
2.1
2,403
0
1
0
null
0
null
1
0
0
-236.65
92.09
5
0
-421.85
1
0
null
1
Infection
Mild
0
0
70
1
-194.09
0
0
0
New_bilateral_GGO
2.08
16.48
50
8.48
10.89
13.41
7.9
14
3.44
2.62
1.83
10.25
1
Respiratory_failure
67.33
1
33
1
0
52.13
51.95
0.39
14.41
14.78
1
0
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000073
HC-GEN-001
IPF
68.08
Female
White_non_Hispanic
Ex_smoker
North_America
Middle
0
0
UIP_Definite
37.85
0
1
14.67
0
null
0
2.67
1
Academic_ILD_Center
PARN
null
4.18
0
null
null
GG_wildtype
0
Targeted_panel_150gene
Pathogenic
Heterozygous
High
81.32
32.75
74.57
0.9
571.41
71.99
91.14
0
1
1
5.09
0
31.76
-164.46
-3.78
Moderate
[81.32, 48.43, 15.53, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-39.5
0
0
0
0
2
2
0
0
null
0
null
0
0
Other
6
0
0
1
Lymphocytic
22.32
8.82
1
1
0
4
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Pirfenidone
5.38
2,403
0
0
0
null
1
Moderate
0
0
0
-74.92
87.82
6
0
-313.07
0
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
17.77
50
6.18
18.03
8.74
20.79
5
4.72
1.8
6.23
10.13
1
Respiratory_failure
35.19
1
7
1.8
1
35.65
82.34
0.85
3.98
13.95
1
1
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000074
HC-GEN-001
IPF
35
Male
White_non_Hispanic
Ex_smoker
North_America
Low
0
0
UIP_Definite
21.12
1
1
13.78
0
null
0
15.69
1
Academic_ILD_Center
TINF2
null
8.59
0
null
null
GG_wildtype
0
Targeted_panel_150gene
Pathogenic
Heterozygous
High
73.63
62.3
46.1
0.86
381.7
89.49
88.02
0
0
0
0
0
34.32
-325.26
-2.47
Rapid
[73.63, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-60.32
1
0
1
1
2
3
0
0
null
1
null
1
0
Streptococcus
0
0
0
0
null
null
null
0
0
0
5
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Pirfenidone
3.78
2,403
0
0
0
null
1
Mild
0
0
0
-82.49
95.11
3
0
-109.94
0
0
null
1
Idiopathic
Critical
0
0
36
0
-395.1
1
0
0
New_bilateral_GGO
1.55
35.96
50
2.49
18.37
20.2
5.05
5
5.15
4.66
4.3
10.88
0
null
null
0
3
1.03
0
42.26
26.87
0.73
8.07
8.13
1
1
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000075
HC-GEN-001
SP_Mutation_PF
84.61
Male
Black
Ex_smoker
Europe
High
0
0
UIP_Definite
32.1
1
0
7.74
1
UIP
1
12.87
0
Community_Pulmonology
NAF1
null
4.29
0
SFTPC
L188Q
TG_heterozygous
1
WES
VUS
Heterozygous
Intermediate
61.68
69.91
68.01
0.87
419.51
87.41
93.72
0
0
0
0
1
27.95
-291.42
-2.01
Rapid
[61.68, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-45.8
1
0
0
0
3
0
0
0
null
0
null
0
0
Pseudomonas_aeruginosa
2
0
0
1
Lymphocytic
14.49
5.39
1
1
1
3
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Pirfenidone
6.28
801
0
0
0
null
1
Moderate
1
1
0
-52.28
81.5
5
0
-285.21
1
1
9.71
0
null
null
null
null
null
null
null
null
null
null
null
null
25.82
58.11
6.1
11.83
25.78
5
7
7.37
3.43
16.9
11.09
1
Respiratory_failure
49
1
9
1.56
0
41.76
54.84
0.66
0.04
4.15
0
1
CB03.10
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000076
HC-GEN-001
IPF
70.51
Male
White_non_Hispanic
Never
Europe
Middle
0
0
UIP_Definite
63.44
0
0
26.76
0
null
6
35.39
1
Academic_ILD_Center
TERT
Frameshift
3.71
1
null
null
TG_heterozygous
1
WGS
VUS
Heterozygous
Intermediate
54.99
21.05
73.04
0.9
393.02
98
96
0
1
1
0.5
0
25.27
-375.87
-0.5
Rapid
[54.99, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
0
1
0
0
0
2
2
1
0
null
0
null
0
0
Streptococcus
0
1
0
0
null
null
null
0
1
0
4
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Neither
null
0
0
0
0
null
0
null
0
0
0
null
null
0
0
-207.02
0
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
10.91
50
9.05
27.71
9.59
7.69
5
2.66
2.32
10.77
10.5
0
null
null
1
16
2
1
25.93
44.35
0.55
7.59
10.18
1
0
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000077
HC-GEN-001
FPF
43.95
Male
White_non_Hispanic
Ex_smoker
Europe
Middle
1
7
UIP_Indeterminate
60.96
1
1
7.9
0
null
0
13.57
1
Community_Pulmonology
NAF1
null
4.87
0
null
null
GG_wildtype
0
WGS
Likely_pathogenic
Heterozygous
High
52.56
45.4
65.44
0.9
342
81.36
97.33
0
0
1
0.5
0
34.51
-340.89
-5.5
Rapid
[52.56, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-30.25
1
0
0
0
2
0
0
0
null
0
null
0
0
Pseudomonas_aeruginosa
1
0
0
0
null
null
null
1
1
1
2
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Pirfenidone
0.5
801
0
0
0
null
0
null
1
0
0
-144.14
88.96
6
0
-219.67
0
0
null
1
Procedure
Moderate
1
0
36
0
-268.1
1
0
0
New_bilateral_GGO
24.14
50.61
50
9.72
10
14.86
7.79
8
9.03
1.03
6.18
11.48
1
Respiratory_failure
78.86
1
11
1.48
0
41.98
44.05
0.76
13.65
5.88
0
0
CB03.10
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000078
HC-GEN-001
DC_PF
18
Male
Black
Ex_smoker
Other
Middle
0
0
UIP_Definite
72.84
1
1
21
0
null
8
14.56
1
Tertiary_Hospital
TINF2
null
5.31
0
null
null
GG_wildtype
0
WES
Likely_pathogenic
Heterozygous
Low
60.55
32.23
73.8
0.9
294.58
80.95
98.01
0
1
0
0
0
34.41
-177.83
-3.93
Moderate
[60.55, 24.99, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-9.71
0
1
0
0
3
4
1
0
null
0
null
0
0
Streptococcus
1
0
0
1
Mixed
33.46
3.5
0
0
0
7
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Pirfenidone
1.37
1,602
0
0
0
null
0
null
1
0
0
-126.3
83.3
1
0
-292.98
0
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
28.93
50
10.54
10
7.51
6.53
16
14
2.65
3.77
10.38
0
null
null
0
14
0
0
42.14
61.81
0.85
6.65
1.23
0
1
CB03.10
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000079
HC-GEN-001
HPS_PF
46.43
Male
White_non_Hispanic
Never
Asia_Pacific
Middle
0
0
UIP_Definite
33.02
1
1
28.27
0
null
6
43.56
0
Community_Pulmonology
PARN
null
7.04
0
null
null
TG_heterozygous
1
WES
VUS
Heterozygous
Low
52.61
45.54
75.44
0.94
397.16
81.25
96.06
0
0
0
0
1
38.51
-98.49
-3.24
Slow
[52.61, 32.91, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-45.96
0
0
0
0
1
6
0
0
null
0
null
0
0
MRSA
2
1
0
0
null
null
null
1
1
0
7
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Nintedanib
0.56
0
300
0
0
null
0
null
0
0
0
-94
85.49
3
0
-251.47
0
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
33.15
50
4.85
10
22.96
10.91
9
8.63
6.26
10.71
10.87
0
null
null
0
18
0.38
1
39.37
79.29
0.63
5.26
1.23
0
1
CB03.10
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000080
HC-GEN-001
FPF
48.74
Male
White_non_Hispanic
Ex_smoker
North_America
High
1
7
UIP_Indeterminate
51.59
0
0
14.76
1
UIP
2
33.13
1
Academic_ILD_Center
RTEL1
null
4.45
0
null
null
GG_wildtype
0
WES
Pathogenic
Heterozygous
High
58.7
54.61
49.4
0.91
181.86
82.64
92.31
0
0
1
3.65
1
43.38
-274.93
-5.25
Rapid
[58.7, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-24.88
1
0
0
0
2
2
0
0
null
0
null
1
0
Other
4
0
0
0
null
null
null
1
1
0
4
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Neither
null
0
0
0
0
null
0
null
0
0
0
null
null
0
0
-269.53
0
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
43.99
66.63
8.27
10.55
14.49
5
13
3.69
4.28
9.73
11.22
0
null
null
0
33
3.1
0
24.81
84.42
0.86
8.97
11.22
0
1
CB03.10
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000081
HC-GEN-001
IPF
85
Male
White_non_Hispanic
Ex_smoker
North_America
High
0
0
UIP_Probable
67.34
1
1
18.35
1
Non_specific_IP
8
1.39
0
Primary_Care
PARN
null
8.67
0
null
null
GG_wildtype
0
Targeted_panel_150gene
Benign
Compound_het
Intermediate
30.32
43.79
68.28
0.81
321.7
83.18
87.89
1
0
0
0
0
20.2
-166.94
-2.28
Moderate
[30.32, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-6.81
1
1
1
1
4
7
0
0
null
0
null
0
0
Other
9
0
0
0
null
null
null
1
1
0
11
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Pirfenidone
5.01
801
0
0
1
Hepatotoxicity
1
Mild
1
0
0
-140.39
79.2
3
0
-327.93
1
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
11.96
50
6.1
12.2
22.91
7.14
8
2.32
1.7
2.12
10.28
0
null
null
0
5
0
1
39.04
61.5
0.56
12.6
9.68
1
0
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000082
HC-GEN-001
IPF
79.96
Male
White_non_Hispanic
Current
Europe
High
0
0
UIP_Definite
26.51
1
0
13.1
0
null
5
11.51
1
Academic_ILD_Center
TERC
null
2.98
1
null
null
TG_heterozygous
1
WES
VUS
Heterozygous
High
58.67
44.75
61.24
0.89
315.59
86.93
93.96
0
0
1
0.75
0
44.72
-259.33
-5.12
Rapid
[58.67, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-51.31
1
1
1
1
3
2
0
0
null
0
null
0
0
Haemophilus
0
0
0
1
Neutrophilic
31.15
3.54
1
1
1
5
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Pirfenidone
1.1
2,403
0
0
1
GI_intolerance
1
Moderate
0
0
0
-28.91
86.43
0
0
-284.87
1
0
null
1
Drug
Severe
0
0
34
1
-417.74
1
1
0
New_bilateral_GGO
1.89
56.46
50
6.35
11.66
49.85
8.2
12
3.13
2.92
6.1
12.51
1
Respiratory_failure
11.77
0
16
1.89
0
19.93
48.27
0.62
1.95
6.49
0
0
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000083
HC-GEN-001
DC_PF
52.33
Male
White_non_Hispanic
Ex_smoker
Asia_Pacific
Low
0
0
Non_UIP
40.96
1
1
10.65
1
UIP
2
3.95
0
Academic_ILD_Center
TERT
Missense
5
0
null
null
GG_wildtype
0
WES
VUS
Heterozygous
Intermediate
63.46
68.44
81.59
0.88
388.41
86.42
82.48
0
0
0
0
1
52.94
-48.11
-1.41
Slow
[63.46, 53.83, 44.21, 34.59, 24.97, 15.34, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-33.25
1
0
0
0
0
1
0
0
null
0
null
0
0
MRSA
1
0
0
0
null
null
null
1
1
0
1
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Nintedanib
11.84
0
150
1
1
Hepatotoxicity
1
Mild
0
0
0
-149.85
90.9
5
0
-318.71
0
0
null
1
Idiopathic
Moderate
1
0
20
1
-306.27
1
1
0
New_bilateral_GGO
2.6
77.88
50.81
5.32
19.48
12.58
14.36
14
2.58
4.44
10.46
11.84
0
null
null
0
30
1.8
0
40.81
72.24
0.69
9.09
11.44
0
0
CB03.10
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000084
HC-GEN-001
IPF
66.66
Male
White_non_Hispanic
Ex_smoker
North_America
Middle
0
0
UIP_Definite
18.35
1
1
6.36
0
null
0
12.76
1
Academic_ILD_Center
TERT
Missense
9.56
0
null
null
GG_wildtype
0
WGS
VUS
Heterozygous
High
60.64
34.78
71.36
0.93
341.13
83.54
91.51
0
1
1
6.55
1
32.48
-157.14
-0.77
Moderate
[60.64, 29.22, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
0
0
0
0
0
1
3
0
0
null
0
null
1
0
Pseudomonas_aeruginosa
1
1
0
1
Lymphocytic
14.72
4.76
1
0
0
4
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Nintedanib
2.69
0
300
1
0
null
0
null
0
0
0
-93.5
93.82
2
0
-279.06
1
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
31.13
50
7.14
10
13.29
19.78
12
4.15
15
3.19
10.62
0
null
null
0
15
1.43
0
32.9
60.88
0.81
11.15
12.68
1
1
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000085
HC-GEN-001
IPF
68.3
Male
Hispanic
Ex_smoker
Europe
Middle
0
0
Non_UIP
27.11
1
0
16.12
0
null
4
33.62
0
Community_Pulmonology
TERC
null
3.12
1
null
null
GG_wildtype
0
WES
Pathogenic
Heterozygous
High
81.62
56.2
75.64
0.94
529.23
96.61
89.3
0
0
1
2.06
0
24.28
-332.33
-0.5
Rapid
[81.62, 15.15, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-21.13
1
1
1
1
2
4
0
0
null
0
null
0
0
Pseudomonas_aeruginosa
2
1
0
0
null
null
null
1
1
0
6
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Pirfenidone
4.41
801
0
0
0
null
1
Moderate
0
0
0
-141.37
96.19
3
0
-171
0
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
17.49
50
13.76
21.7
24.46
9.32
13
3.84
2.73
5.53
11.97
0
null
null
0
8
1.51
1
25.62
75.39
0.68
1.78
8.86
0
1
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000086
HC-GEN-001
IPF
74.48
Female
White_non_Hispanic
Ex_smoker
Asia_Pacific
Middle
0
0
UIP_Indeterminate
17.51
1
1
23.5
0
null
4
11.82
1
Tertiary_Hospital
TERT
Splice_site
5.27
0
null
null
TG_heterozygous
1
Clinical_sanger
Pathogenic
Heterozygous
Intermediate
71.18
39.69
67.65
0.85
303.2
83.95
95.15
0
1
1
2.78
1
22
-88.57
-5.62
Slow
[71.18, 53.46, 35.75, 18.04, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-13.59
0
1
1
1
4
1
0
0
null
0
null
0
0
Other
0
0
0
0
null
null
null
1
1
1
5
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Nintedanib
1.45
0
300
0
0
null
1
Moderate
0
0
0
-117.98
84.9
6
0
-281.6
0
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
13.23
56.78
6.31
10
20.72
7.92
1
2.37
5.63
6.42
10.12
1
Respiratory_failure
25.03
0
5
3.64
1
40.39
63.78
0.62
0
8.34
0
1
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000087
HC-GEN-001
IPF
77.49
Male
White_non_Hispanic
Ex_smoker
Europe
Middle
0
0
UIP_Definite
60.37
1
0
14.19
0
null
3
9.79
1
Academic_ILD_Center
TERC
null
6.24
0
null
null
GG_wildtype
0
WGS
VUS
Heterozygous
Low
40.25
36.38
53.13
0.89
523.9
84.4
92.33
1
1
0
0
1
34.47
-152.55
-2.94
Moderate
[40.25, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
0
1
0
0
0
3
2
0
1
fumigatus
1
Itraconazole
1
0
MRSA
2
0
0
1
Neutrophilic
13.92
8.68
1
1
0
5
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Nintedanib
1.12
0
300
0
0
null
1
Moderate
0
0
0
-23.13
84.54
5
0
-179.89
0
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
26.01
50
4.41
19.99
40.96
12.23
13
9.3
4.39
7.62
11.77
1
Respiratory_failure
25.11
0
29
1.02
0
48.33
46.88
0.5
6.8
2.28
0
0
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000088
HC-GEN-001
IPF
66.09
Female
Black
Ex_smoker
Europe
Middle
0
0
UIP_Probable
64.85
1
1
11.3
0
null
6
19.42
1
Primary_Care
null
null
6.54
0
null
null
GG_wildtype
0
WES
Likely_pathogenic
Heterozygous
Low
81.93
36.58
53.47
0.87
378.69
79.25
90.32
0
1
1
1.17
0
25.51
-128.79
-1.81
Moderate
[81.93, 56.17, 30.41, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-56.46
1
0
0
0
1
1
0
0
null
1
null
1
0
Streptococcus
1
0
0
1
Neutrophilic
11.65
3.21
1
0
0
2
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Nintedanib
19.98
0
300
0
0
null
0
null
0
0
0
-250.68
77.18
2
0
-210
0
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
27.33
50
3.99
10
13.5
18.65
3
3.49
3.49
4.89
10.02
1
Respiratory_failure
24.3
0
34
1.86
0
30.37
71.86
0.83
0
4.67
1
1
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000089
HC-GEN-001
IPF
70.72
Male
Asian
Ex_smoker
North_America
Middle
1
0
UIP_Definite
60.44
1
1
29.55
0
null
7
21.4
0
Academic_ILD_Center
NAF1
null
9.39
0
null
null
TG_heterozygous
1
Targeted_panel_150gene
Pathogenic
Heterozygous
Low
38.25
55.9
53.46
0.92
161.72
84.11
92.64
1
0
0
0
0
28.43
-194
-4.44
Moderate
[38.25, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-29.79
1
0
0
0
1
2
1
0
null
0
null
0
0
Streptococcus
3
0
0
0
null
null
null
1
0
0
3
1
AAV5_SFTPC
Placebo
AAV5
Intratracheal_instillation
100,000,000,000
1.52
66.5
5.18
96.06
-120.62
-4.71
0
0
0
0
0
35.07
1
169.37
9.14
Nintedanib
3.26
0
300
1
0
null
1
Moderate
0
0
0
-274.77
92.68
1
0
-264.04
0
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
12.82
50
5.76
12.17
16.52
8.88
2
6.68
3.33
25
9.98
1
Respiratory_failure
27.45
1
16
1
1
36.3
29.37
0.88
5.48
8.34
0
1
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000090
HC-GEN-001
FPF
57.56
Female
White_non_Hispanic
Ex_smoker
Europe
Low
1
8
UIP_Definite
43.6
0
0
28.27
0
null
0
10.33
0
Tertiary_Hospital
TERC
null
2.98
1
null
null
GG_wildtype
0
Targeted_panel_150gene
VUS
Heterozygous
Intermediate
41.6
57.49
69.92
0.91
355.13
87.48
91.76
1
0
0
0
0
41.89
-50
-2.75
Slow
[41.6, 31.6, 21.6, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
0
1
0
1
1
1
1
0
0
null
0
null
0
0
Haemophilus
13
1
0
1
Lymphocytic
15.52
6.68
0
0
0
2
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Neither
null
0
0
0
0
null
0
null
0
0
0
null
null
0
0
-209.57
0
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
104.86
50
5.81
10
10.12
10.74
5
3.19
2.54
3.04
11.39
0
null
null
0
23
2.43
1
37.13
56.14
0.65
10.94
3.73
0
0
CB03.10
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000091
HC-GEN-001
FPF
56.53
Female
Hispanic
Never
North_America
Middle
1
3
UIP_Indeterminate
43.69
1
1
18.49
1
RB-ILD
6
1
1
Tertiary_Hospital
TERC
null
1.66
1
null
null
GG_wildtype
0
WGS
VUS
Heterozygous
Intermediate
61.01
48.35
71.67
0.88
284.29
90.74
91.33
0
0
0
0
0
31.23
-134.63
-6.37
Moderate
[61.01, 34.08, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-58.74
1
0
0
0
3
3
0
0
null
0
null
1
1
Pseudomonas_aeruginosa
4
0
0
0
null
null
null
1
0
0
6
1
AAV9_TERT
Placebo
AAV6
IV_systemic
100,000,000,000
18.36
30.91
1.46
8.22
-113.89
2.29
0
1
0
0
0
12.43
0
120.22
26.85
Pirfenidone
3.07
2,403
0
0
0
null
0
null
1
0
0
-50.77
85.18
4
0
-122.07
0
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
48.16
50
5.07
10
48.04
6.21
0
3.16
4.17
10.47
11.99
0
null
null
0
10
1.01
0
26.73
46.63
0.68
0
7.84
1
0
CB03.10
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000092
HC-GEN-001
IPF
68.88
Male
White_non_Hispanic
Ex_smoker
North_America
Middle
0
0
UIP_Probable
39.44
1
1
22.67
0
null
0
20.73
1
Primary_Care
PARN
null
4.58
0
null
null
TG_heterozygous
1
WES
Likely_pathogenic
Heterozygous
Low
74.94
48.15
68.99
0.92
361.48
83.39
93.83
0
0
0
0
1
22.72
-166.36
-1.97
Moderate
[74.94, 41.67, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-32.66
0
0
0
0
1
3
1
0
null
0
null
0
0
Streptococcus
0
0
0
0
null
null
null
0
1
1
4
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Nintedanib
10.23
0
300
0
0
null
1
Moderate
0
0
0
-271.32
91.74
5
0
-350.6
1
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
10.13
50
5.8
20.09
22.38
9.21
4
6.02
1.75
15.08
10.53
0
null
null
1
21
1.28
0
24.43
54.99
0.88
14.44
6.03
1
1
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000093
HC-GEN-001
IPF
46.74
Male
White_non_Hispanic
Never
Europe
Low
0
0
UIP_Definite
49.48
1
0
14.34
1
UIP
8
17.08
0
Academic_ILD_Center
RTEL1
null
4.31
0
null
null
GG_wildtype
0
WGS
VUS
Heterozygous
High
87.46
51.98
57.73
0.9
326.85
81.41
95.64
0
0
0
0
1
33.89
-244.89
-3.35
Moderate
[87.46, 38.48, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-40.07
1
1
1
1
3
2
0
0
null
0
null
0
0
MRSA
8
0
0
1
Neutrophilic
3.5
11.58
1
1
0
5
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Nintedanib
0.9
0
150
0
0
null
0
null
0
0
0
-114.3
70.42
2
0
-298.67
1
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
21.94
50
12.17
10
33.55
8.21
11
6.26
2.2
7.82
11.65
1
Respiratory_failure
99.07
0
15
0
1
49.66
41.8
0.7
12.54
7.63
0
1
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000094
HC-GEN-001
IPF
53.14
Male
White_non_Hispanic
Ex_smoker
North_America
High
0
0
UIP_Definite
60.13
1
1
23
0
null
3
44.47
1
Community_Pulmonology
PARN
null
3.53
1
null
null
GG_wildtype
0
WGS
VUS
Heterozygous
Low
63.93
42.93
70.01
0.86
413.85
96.77
90.18
0
0
0
0
1
22.87
-196.9
-6.92
Moderate
[63.93, 24.55, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-47.78
1
1
1
1
3
3
0
0
null
0
null
0
0
MRSA
1
1
0
1
Lymphocytic
5.32
11.29
1
1
1
6
1
Other
Treatment
AAV5
IV_systemic
100,000,000,000
3.62
67.31
2.26
138.39
362.39
8.38
1
0
0
0
0
7.19
1
18.68
11.17
Pirfenidone
17.65
801
0
0
0
null
0
null
1
0
0
-160.84
55.78
1
0
-298.17
0
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
36.88
50
12.26
11.12
24.22
9.19
7
2.53
3.09
10.91
11.94
1
Respiratory_failure
4.46
1
18
0.29
0
37.37
93.4
0.54
8.81
5.21
1
1
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000095
HC-GEN-001
IPF
73.99
Female
Black
Ex_smoker
Europe
Middle
0
0
UIP_Probable
35.73
0
0
4.81
1
UIP
7
11.54
0
Tertiary_Hospital
TERT
Missense
4.99
0
null
null
TG_heterozygous
1
WES
VUS
Heterozygous
Low
71.98
75.99
69.12
0.92
422.77
85.81
94.65
0
0
1
7.7
0
42.07
-198.81
-4.93
Moderate
[71.98, 32.22, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-52.73
1
0
0
0
1
3
0
0
null
0
null
1
1
Other
5
0
0
1
Neutrophilic
19.86
13.74
1
1
1
4
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Pirfenidone
18.16
2,403
0
0
0
null
1
Moderate
0
0
0
-222.43
84.51
1
0
-60
1
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
39.62
50
7.31
12.31
8.39
5.41
9
4.76
2.33
3.47
10.65
0
null
null
1
25
1
0
43.29
40.93
0.63
10.76
12.34
0
0
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000096
HC-GEN-001
IPF
83.67
Female
Other
Ex_smoker
North_America
Middle
0
0
UIP_Definite
67.79
1
1
12.07
0
null
3
7.94
1
Primary_Care
TERT
Missense
6.42
0
null
null
GG_wildtype
0
Targeted_panel_150gene
Pathogenic
Heterozygous
Low
62.87
73.62
64.56
0.94
358.83
81.15
99
0
0
1
0.5
0
28.53
-92.96
-6.72
Slow
[62.87, 44.28, 25.69, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-53.14
1
0
0
0
0
2
0
0
null
0
null
0
0
Other
1
0
0
0
null
null
null
1
1
0
2
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Pirfenidone
12.73
1,602
0
0
0
null
0
null
1
0
0
-187.82
78.91
0
0
-316.67
0
0
null
1
Idiopathic
Mild
1
0
58
1
-367.31
0
0
1
Consolidation
33.57
9.61
87.79
4.64
22.09
13.7
5
13
10.39
2.11
4.8
9.92
0
null
null
1
10
2.64
1
35.05
38.25
0.74
8.24
7.98
0
1
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000097
HC-GEN-001
IPF
59.79
Male
White_non_Hispanic
Ex_smoker
North_America
High
0
0
UIP_Probable
59.53
1
0
11.66
0
null
4
15.15
0
Community_Pulmonology
RTEL1
null
4.39
0
null
null
TG_heterozygous
1
Targeted_panel_150gene
Likely_pathogenic
Heterozygous
High
60.61
31.58
49.45
0.9
380.81
81.11
87.75
0
1
1
0.5
1
22
-200.19
-1.63
Moderate
[60.61, 20.57, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-40.56
1
1
1
1
3
3
0
0
null
0
null
0
1
Other
0
0
0
0
null
null
null
1
1
0
6
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Pirfenidone
8.68
801
0
0
0
null
0
null
0
0
0
-65.01
87.46
4
0
-186.77
1
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
18.81
50
6.52
10
9.72
5
2
14.75
2.39
22.93
9.77
0
null
null
1
5
3.33
0
39.76
49.54
0.77
3.69
4.46
1
1
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000098
HC-GEN-001
IPF
79.17
Female
White_non_Hispanic
Ex_smoker
Asia_Pacific
Low
0
0
UIP_Definite
64.03
1
0
13.6
0
null
1
41.25
0
Community_Pulmonology
RTEL1
null
6.46
0
null
null
GG_wildtype
0
Targeted_panel_150gene
Pathogenic
Heterozygous
High
64.44
40.39
60.12
0.77
340.51
72.01
86.48
0
0
1
3.21
1
24.03
-177.33
-5.71
Moderate
[64.44, 28.97, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-72.09
1
1
0
0
3
1
0
0
null
0
null
1
0
MRSA
1
1
0
1
Lymphocytic
18.81
8.96
1
0
0
4
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Pirfenidone
3.98
801
0
1
0
null
1
Severe
0
0
0
-207.24
85.91
1
1
-229.42
0
0
null
1
Infection
Severe
0
0
67
0
-371.46
1
0
0
New_bilateral_GGO
1
41.51
50
10.41
16.55
23.07
8.62
11
2.62
3.67
7.47
12.23
0
null
null
0
3
0.82
0
31.12
96.18
0.4
3.08
11.59
1
1
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000099
HC-GEN-001
IPF
60.84
Female
Black
Never
Europe
Middle
0
0
UIP_Indeterminate
63.39
1
1
10.11
0
null
3
11.77
1
Community_Pulmonology
TERT
Frameshift
5.61
0
null
null
TT_homozygous
1
WES
Pathogenic
Heterozygous
Low
63.91
45.23
58.46
0.89
458.1
83.17
94.14
0
0
1
0.66
0
40.39
-258.94
-3.82
Rapid
[63.91, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
0
0
1
1
1
2
2
0
0
null
0
null
1
0
Pseudomonas_aeruginosa
4
1
0
0
null
null
null
1
1
0
4
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Nintedanib
11.5
0
300
0
0
null
0
null
0
0
0
-20
61.26
6
0
-316.1
1
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
5
50
9.98
11.7
17.69
7.06
4
4.44
3.41
9.31
9.66
0
null
null
0
18
1.95
0
26.62
87.23
0.6
3.32
11.31
1
0
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206
HCGEN001-0000100
HC-GEN-001
IPF
82.21
Female
Hispanic
Ex_smoker
North_America
Middle
0
0
UIP_Definite
36.31
1
1
20.29
1
UIP
0
6.53
0
Tertiary_Hospital
TERC
null
8.75
0
null
null
GG_wildtype
0
WGS
Likely_pathogenic
Heterozygous
Intermediate
55.23
44.35
59.49
0.92
436.78
83.93
96.61
0
0
1
0.97
0
31.71
-230.44
-5.78
Moderate
[55.23, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0, 15.0]
-64.67
1
0
0
0
3
1
0
0
null
0
null
0
0
Pseudomonas_aeruginosa
6
0
0
1
Neutrophilic
36.76
3.94
1
0
0
4
1
AAV9_TERT
Placebo
AAVrh10
Inhaled_nebulized
100,000,000,000
1.68
55.67
7.09
-70.92
-53.7
6.24
0
0
1
0
0
13.86
0
94.55
14.37
Neither
null
0
0
0
0
null
0
null
0
0
0
null
null
0
0
-184.7
0
0
null
0
null
null
null
null
null
null
null
null
null
null
null
null
17.67
50
6.04
10
8.19
10.17
9
4.77
3.8
3.92
9.49
0
null
null
1
8
1.17
0
47.62
69.16
0.75
7.55
9.77
1
1
CB03.1
40,122,008
19870-5
19871-3
40,121,200
HP:0002206