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README.md ADDED
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+ ---
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+ license: cc-by-nc-4.0
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+ task_categories:
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+ - tabular-classification
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+ - tabular-regression
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+ - time-series-forecasting
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+ tags:
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+ - synthetic-data
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+ - healthcare
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+ - cardiology
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+ - heart-failure
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+ - hf
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+ - hfref
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+ - hfmref
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+ - hfpef
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+ - advanced-heart-failure
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+ - end-stage-heart-failure
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+ - nyha
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+ - lvef
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+ - ejection-fraction
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+ - echocardiography
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+ - echocardiogram
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+ - echo
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+ - diastolic-function
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+ - ase-2016
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+ - ea-ratio
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+ - e-e-prime
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+ - gls
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+ - global-longitudinal-strain
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+ - bnp
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+ - nt-probnp
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+ - troponin
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+ - biomarkers
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+ - ckd-epi
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+ - egfr
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+ - cardiorenal-syndrome
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+ - gdmt
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+ - guideline-directed-medical-therapy
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+ - 4-pillar
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+ - arni
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+ - sglt2i
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+ - entresto
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+ - jardiance
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+ - farxiga
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+ - beta-blocker
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+ - mra
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+ - spironolactone
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+ - ace-inhibitor
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+ - arb
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+ - icd
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+ - crt
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+ - lvad
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+ - heart-transplant
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+ - pinnacle-registry
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+ - aha-2022
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+ - acc-aha-guidelines
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+ - cms-hrrp
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+ - 30-day-readmission
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+ - readmission
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+ - mortality
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+ - mace
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+ - kccq
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+ - six-minute-walk
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+ - vo2-max
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+ - cpet
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+ - atrial-fibrillation
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+ - charlson-comorbidity
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+ - cardiometabolic
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+ - longitudinal-ehr
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+ - ehr-synthetic
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+ pretty_name: HCCAR001 — Synthetic Heart Failure Dataset (Sample)
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+ size_categories:
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+ - 1K<n<10K
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+ configs:
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+ - config_name: baseline
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+ data_files: hccar001_baseline.parquet
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+ - config_name: visits
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+ data_files: hccar001_visits.parquet
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+ ---
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+
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+ # HCCAR001 — Synthetic Heart Failure Dataset (Sample Preview)
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+
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+ **XpertSystems.ai | Synthetic Data Factory | Healthcare / Cardiology Vertical**
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+
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+ A **two-table longitudinal heart failure patient dataset** spanning the
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+ full clinical-research data surface for HF cohorts: baseline patient
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+ records (~114 features per patient covering demographics, full
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+ echocardiographic assessment with diastolic function, 14 biomarkers
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+ including BNP/NT-proBNP/troponin/CKD-EPI eGFR, guideline-directed
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+ medical therapy (GDMT) 4-pillar prescribing, device therapy (ICD/CRT/
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+ LVAD/transplant), hospitalization outcomes, functional status (NYHA,
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+ 6MWD, KCCQ, VO₂ max), comorbidities, and vital signs) plus quarterly
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+ follow-up visits over 3 years tracking LVEF/BNP/NYHA trajectories.
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+
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+ Calibrated benchmark-first against **ACC/AHA 2022 Heart Failure
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+ Guidelines**, **ASE 2016 Recommendations for Evaluation of LV Diastolic
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+ Function**, **CKD-EPI 2009**, **PINNACLE Registry** (real-world GDMT
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+ prescribing rates), **CMS HRRP** (30-day readmission benchmarks),
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+ **SCD-HeFT / DINAMIT** (primary-prevention ICD criteria), and **CARE-HF
100
+ / COMPANION** (CRT eligibility criteria).
101
+
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+ This is the **sample preview** — 200 patients × 12 quarterly visits over
103
+ 3 years (200 baseline records + 2,400 visit records, ~500 KB). The full
104
+ product covers 10,000+ patients × full 3-year follow-up with extended
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+ echocardiographic / CMR modules, full CPET / device interrogation
106
+ detail, complete medication titration trajectories, and pre-built cohort
107
+ configs for HFrEF clinical trial simulation, HFpEF treatment-effect
108
+ heterogeneity studies, and cardiorenal-cardiometabolic comorbidity
109
+ analysis.
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+
111
+ ---
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+
113
+ ## Dataset summary
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+
115
+ | Table | Rows (sample) | What it contains |
116
+ |---|---:|---|
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+ | `baseline` | 200 | One row per patient. 114 features spanning: demographics + enrollment, cardiac function (LVEF, LV dimensions, GLS, RV function, TAPSE), diastolic function (E/A, E/e', LAVI, TRPG, diastolic grade), biomarkers (BNP, NT-proBNP, troponin I/T, creatinine, eGFR, BUN, electrolytes, hemoglobin, CRP, albumin, uric acid, iron studies, CKD stage), GDMT 4-pillar + ARNI/ivabradine/hydralazine-nitrate + device therapy (ICD/CRT/LVAD/transplant), hospitalization (LOS, ICU, 30/90/180-day readmission, ED visits, hospitalization risk score), functional outcomes (6MWD, KCCQ, VO₂ max, EF response, NYHA improvement, MACE, mortality, time-to-event), comorbidities (AF, diabetes, HTN, CAD, valvular, sleep apnea, COPD, anemia, obesity, depression, CCI), and vital signs (HR, SBP/DBP, MAP, weight, SpO₂, JVP, edema grade, rales) |
118
+ | `visits` | 2,400 | Quarterly visit-level records over 12 visits × 3 years. LVEF trajectory, BNP trajectory, NYHA class updates, weight changes — useful for longitudinal modeling, treatment-response trajectories, and time-to-event ML |
119
+
120
+ Both tables provided in **CSV** and **Parquet**. Join on `patient_id`.
121
+
122
+ ---
123
+
124
+ ## Calibration sources
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+
126
+ All ten validation metrics target named clinical / regulatory standards:
127
+
128
+ - **ACC/AHA 2022 HF Guidelines** — HF phenotype LVEF bands (HFrEF ≤40%,
129
+ HFmrEF 41-49%, HFpEF ≥50%, Advanced <30%)
130
+ - **ASE 2016** Recommendations for Evaluation of LV Diastolic Function —
131
+ E/A ratio, E/e', LAVI, TRPG diagnostic criteria
132
+ - **Lang et al. (ASE 2015)** — chamber quantification recommendations
133
+ for LVEDV/LVESV/SV identities
134
+ - **CKD-EPI 2009** — eGFR formula physiologic bounds [8, 140]
135
+ - **PINNACLE Registry** — real-world GDMT 4-pillar prescribing rates
136
+ for outpatient HFrEF cohorts
137
+ - **CMS HRRP** (Hospital Readmissions Reduction Program) — 30-day HF
138
+ readmission national benchmark 22-25% + temporal monotonicity
139
+ - **SCD-HeFT (Bardy et al. 2005) + DINAMIT (Hohnloser et al. 2004)** —
140
+ primary prevention ICD eligibility (LVEF ≤35%, NYHA II-III)
141
+ - **CARE-HF (Cleland et al. 2005) + COMPANION (Bristow et al. 2004)** —
142
+ CRT eligibility (LVEF ≤35%, NYHA III-IV ambulatory, LBBB)
143
+
144
+ ---
145
+
146
+ ## Validation scorecard (seed = 42)
147
+
148
+ 10/10 PASS · **Grade A+ (100%)** across all six canonical seeds (42, 7, 123, 2024, 99, 1).
149
+
150
+ | # | Metric | Observed | Target | Tol | Type | Source |
151
+ |---|---|---:|---:|---:|---|---|
152
+ | 1 | `lvef_in_phenotype_band_rate` | 1.000 | 0.99 | ±0.01 | FLOOR | ACC/AHA 2022 |
153
+ | 2 | `lvesv_equals_lvedv_times_one_minus_ef_rate` | 1.000 | 0.99 | ±0.01 | FLOOR | Lang et al. ASE 2015 |
154
+ | 3 | `stroke_volume_equals_lvedv_minus_lvesv_rate` | 1.000 | 0.99 | ±0.01 | FLOOR | ASE 2015 |
155
+ | 4 | `cardiac_index_equals_co_over_bsa_rate` | 1.000 | 0.99 | ±0.01 | FLOOR | Hemodynamic identity |
156
+ | 5 | `egfr_in_physiologic_bounds_rate` | 1.000 | 0.99 | ±0.01 | FLOOR | CKD-EPI 2009 |
157
+ | 6 | `gdmt_4_pillar_requires_lvef_under_40_rate` | 1.000 | 0.99 | ±0.01 | FLOOR | ACC/AHA 2022 + PINNACLE |
158
+ | 7 | `icd_requires_lvef_under_35_and_nyha_ge_2_rate` | 1.000 | 0.99 | ±0.01 | FLOOR | SCD-HeFT / DINAMIT |
159
+ | 8 | `crt_requires_lvef_under_35_and_nyha_ge_3_rate` | 1.000 | 0.99 | ±0.01 | FLOOR | CARE-HF / COMPANION |
160
+ | 9 | `readmission_temporal_ordering_rate` | 1.000 | 0.99 | ±0.01 | FLOOR | CMS HRRP |
161
+ | 10 | `ea_ratio_equals_e_over_a_rate` | 1.000 | 0.99 | ±0.01 | FLOOR | ASE 2016 |
162
+
163
+ ---
164
+
165
+ ## Schema highlights
166
+
167
+ ### `baseline` (200 rows × 114 cols)
168
+
169
+ **Demographics (11 cols):** `patient_id` (UUID), `site_id`,
170
+ `hf_phenotype` (HFrEF / HFmrEF / HFpEF / Advanced), `age_at_baseline`,
171
+ `sex_male`, `race_ethnicity` (5 categories), `bmi_kg_m2`, `bsa_m2`,
172
+ `nyha_class_baseline` (1-4), `index_hospitalization`, `enrollment_date`.
173
+
174
+ **Cardiac function (13 cols):** `lvef_pct_baseline`, `lvedd_mm_baseline`,
175
+ `lvesd_mm_baseline`, `lvedv_ml_baseline`, `lvesv_ml_baseline`,
176
+ `stroke_volume_ml_baseline`, `heart_rate_baseline_bpm`,
177
+ `cardiac_output_l_min_baseline`, `cardiac_index_l_min_m2_baseline`,
178
+ `gls_pct_baseline`, `rv_function_baseline`, `tapse_mm_baseline`,
179
+ `echo_quality_baseline`.
180
+
181
+ **Diastolic function (9 cols):** `diastolic_grade_baseline` (Grade_1 /
182
+ Grade_2 / Grade_3 / Indeterminate), `e_velocity_cm_s_baseline`,
183
+ `a_velocity_cm_s_baseline`, `ea_ratio_baseline`, `e_prime_cm_s_baseline`,
184
+ `e_e_prime_ratio_baseline`, `lavi_ml_m2_baseline`, `trpg_mmhg_baseline`,
185
+ `ivrt_ms_baseline`.
186
+
187
+ **Biomarkers (15 cols):** `bnp_pg_ml_baseline`, `nt_probnp_pg_ml_baseline`,
188
+ `troponin_i_ng_ml_baseline`, `troponin_t_ng_ml_baseline`,
189
+ `creatinine_mg_dl_baseline`, `egfr_ml_min_173m2_baseline`,
190
+ `bun_mg_dl_baseline`, `sodium_meq_l_baseline`, `potassium_meq_l_baseline`,
191
+ `hemoglobin_g_dl_baseline`, `iron_studies_baseline`, `crp_mg_l_baseline`,
192
+ `albumin_g_dl_baseline`, `uric_acid_mg_dl_baseline`, `ckd_stage_baseline`.
193
+
194
+ **Treatment & GDMT (14 cols):** `gdmt_acei_arb_arni`, `gdmt_betablocker`,
195
+ `gdmt_mra`, `gdmt_sglt2i`, `gdmt_4_pillar_flag`, `arni_flag`,
196
+ `ivabradine_flag`, `hydralazine_nitrate_flag`, `icd_flag`, `crt_flag`,
197
+ `lvad_flag`, `transplant_flag`, `diuretic_loop_dose_mg`,
198
+ `gdmt_dose_optimization_pct`.
199
+
200
+ **Hospitalization (13 cols):** `hospitalization_count_3yr`,
201
+ `index_los_days`, `index_icu_flag`, `readmission_30d_flag`,
202
+ `readmission_90d_flag`, `readmission_180d_flag`, `readmission_cause`,
203
+ `iv_diuretic_flag`, `diuretic_response_ml_mg`,
204
+ `discharge_congestion_score`, `ed_visit_count_1yr`,
205
+ `days_to_readmission`, `hospitalization_risk_score`.
206
+
207
+ **Functional outcomes (15 cols):** `six_mwd_meters_baseline`,
208
+ `kccq_overall_score_baseline`, `vo2_max_ml_kg_min_baseline`,
209
+ `lvef_change_12m_pct`, `ef_response_flag`, `nyha_improvement_flag`,
210
+ `six_mwd_trend_12m_meters`, `kccq_change_12m`, `mace_flag_3yr`,
211
+ `mortality_flag_3yr`, `cv_death_flag_3yr`, `time_to_death_days`,
212
+ `borg_dyspnea_scale_baseline`, `patient_global_impression_12m`,
213
+ `cpet_reason`.
214
+
215
+ **Comorbidities & vitals (25 cols):** `atrial_fibrillation_flag`,
216
+ `af_type`, `diabetes_flag`, `diabetes_type`, `hypertension_flag`,
217
+ `cad_flag`, `prior_mi_flag`, `valvular_disease`, `sleep_apnea_flag`,
218
+ `copd_flag`, `anemia_flag`, `obesity_flag`, `depression_flag`,
219
+ `charlson_comorbidity_index`, `heart_rate_bpm_baseline`,
220
+ `systolic_bp_mmhg_baseline`, `diastolic_bp_mmhg_baseline`,
221
+ `pulse_pressure_mmhg_baseline`, `map_mmhg_baseline`,
222
+ `weight_kg_baseline`, `oxygen_saturation_pct_baseline`,
223
+ `jvp_cmh2o_baseline`, `peripheral_edema_grade_baseline`,
224
+ `rales_flag_baseline`.
225
+
226
+ ### `visits` (2,400 rows × 11 cols)
227
+ `patient_id`, `visit_number` (1-12), `visit_date`,
228
+ `months_from_baseline` (0-33), `hf_phenotype`, `nyha_class_visit`,
229
+ `lvef_pct_visit`, `lvef_trend_visit`, `bnp_pg_ml_visit`,
230
+ `bnp_trend_pct_visit`, `weight_change_kg_visit`.
231
+
232
+ ---
233
+
234
+ ## Suggested use cases
235
+
236
+ - **HF phenotype classification ML** — train classifiers for
237
+ HFrEF / HFmrEF / HFpEF / Advanced from echo + biomarker features
238
+ - **30-day readmission prediction** — classifier on
239
+ `readmission_30d_flag` from demographics, biomarkers, GDMT status,
240
+ hospitalization risk features (CMS HRRP-relevant)
241
+ - **GDMT optimization ML** — predict which patients are eligible for
242
+ 4-pillar therapy, which are likely to achieve target doses
243
+ - **Mortality / MACE risk stratification** — Cox models or survival
244
+ forests on `mortality_flag_3yr` + `time_to_death_days` with right-
245
+ censoring
246
+ - **EF response prediction** — regressor for `lvef_change_12m_pct` from
247
+ baseline echo + GDMT + biomarkers; identifies likely responders
248
+ - **Diastolic function classification** — train multi-class on
249
+ `diastolic_grade_baseline` (Grade 1/2/3/Indeterminate) from E/A, E/e',
250
+ LAVI features per ASE 2016
251
+ - **Cardiorenal risk modeling** — joint modeling of `egfr_ml_min_173m2`
252
+ trajectory and `bnp_pg_ml` trajectory across visits; useful for
253
+ cardiorenal syndrome detection
254
+ - **NLP-augmented EHR research** — table provides structured ground
255
+ truth for NLP extraction from clinical notes; pair with synthetic
256
+ clinical text generators
257
+ - **Clinical trial cohort simulation** — filter to specific eligibility
258
+ criteria (e.g., HFrEF + NYHA II-III + LVEF ≤35% + eGFR ≥30) and
259
+ benchmark expected event rates / power calculations
260
+ - **Treatment effect heterogeneity** — train uplift / CATE models for
261
+ SGLT2i, ARNI, MRA effects across phenotype subgroups
262
+ - **Longitudinal LVEF / BNP trajectory clustering** — unsupervised
263
+ clustering on visit-level trajectories to discover responder
264
+ phenotypes
265
+ - **NYHA class transitions** — Markov / state-space models on
266
+ `nyha_class_visit` transitions
267
+ - **Device therapy appropriateness ML** — train models that flag
268
+ potential under-utilization of ICD/CRT in eligible patients
269
+ - **Hospitalization cost / utilization modeling** — combine
270
+ `index_los_days`, `index_icu_flag`, `ed_visit_count_1yr`,
271
+ `hospitalization_count_3yr` for utilization predictive analytics
272
+
273
+ ---
274
+
275
+ ## Loading examples
276
+
277
+ ```python
278
+ from datasets import load_dataset
279
+
280
+ baseline = load_dataset("xpertsystems/hccar001-sample", "baseline", split="train")
281
+ visits = load_dataset("xpertsystems/hccar001-sample", "visits", split="train")
282
+ print(baseline.shape, visits.shape)
283
+ ```
284
+
285
+ ```python
286
+ import pandas as pd
287
+ from huggingface_hub import hf_hub_download
288
+
289
+ baseline = pd.read_parquet(hf_hub_download(
290
+ "xpertsystems/hccar001-sample", "hccar001_baseline.parquet",
291
+ repo_type="dataset",
292
+ ))
293
+ visits = pd.read_parquet(hf_hub_download(
294
+ "xpertsystems/hccar001-sample", "hccar001_visits.parquet",
295
+ repo_type="dataset",
296
+ ))
297
+
298
+ # HF phenotype distribution (ACC/AHA 2022)
299
+ print(baseline["hf_phenotype"].value_counts(normalize=True).round(3))
300
+ ```
301
+
302
+ ```python
303
+ # GDMT 4-pillar prescribing in HFrEF
304
+ import pandas as pd
305
+ from huggingface_hub import hf_hub_download
306
+
307
+ baseline = pd.read_parquet(hf_hub_download(
308
+ "xpertsystems/hccar001-sample", "hccar001_baseline.parquet",
309
+ repo_type="dataset",
310
+ ))
311
+
312
+ hfref = baseline[baseline["hf_phenotype"] == "HFrEF"]
313
+ gdmt_rates = hfref[[
314
+ "gdmt_acei_arb_arni", "gdmt_betablocker",
315
+ "gdmt_mra", "gdmt_sglt2i", "gdmt_4_pillar_flag"
316
+ ]].mean().round(3) * 100
317
+ print("HFrEF GDMT prescribing rates (%):")
318
+ print(gdmt_rates)
319
+ ```
320
+
321
+ ```python
322
+ # Longitudinal LVEF trajectory by GDMT status
323
+ import pandas as pd
324
+ from huggingface_hub import hf_hub_download
325
+
326
+ baseline = pd.read_parquet(hf_hub_download(
327
+ "xpertsystems/hccar001-sample", "hccar001_baseline.parquet",
328
+ repo_type="dataset",
329
+ ))
330
+ visits = pd.read_parquet(hf_hub_download(
331
+ "xpertsystems/hccar001-sample", "hccar001_visits.parquet",
332
+ repo_type="dataset",
333
+ ))
334
+
335
+ joined = visits.merge(
336
+ baseline[["patient_id", "gdmt_4_pillar_flag", "gdmt_sglt2i"]],
337
+ on="patient_id"
338
+ )
339
+ joined["responder_group"] = joined["gdmt_4_pillar_flag"] | joined["gdmt_sglt2i"]
340
+ trajectory = (
341
+ joined.groupby(["responder_group", "visit_number"])
342
+ ["lvef_pct_visit"].mean().unstack(level=0).round(2)
343
+ )
344
+ print(trajectory) # responder group LVEF trajectory recovers; control doesn't
345
+ ```
346
+
347
+ ```python
348
+ # 30-day readmission risk by HF phenotype
349
+ import pandas as pd
350
+ from huggingface_hub import hf_hub_download
351
+
352
+ baseline = pd.read_parquet(hf_hub_download(
353
+ "xpertsystems/hccar001-sample", "hccar001_baseline.parquet",
354
+ repo_type="dataset",
355
+ ))
356
+
357
+ risk = baseline.groupby("hf_phenotype").agg(
358
+ n=("patient_id", "count"),
359
+ readmit_30d_pct=("readmission_30d_flag", lambda x: x.mean() * 100),
360
+ readmit_90d_pct=("readmission_90d_flag", lambda x: x.mean() * 100),
361
+ mean_nyha=("nyha_class_baseline", "mean"),
362
+ mean_bnp=("bnp_pg_ml_baseline", "mean"),
363
+ ).round(2)
364
+ print(risk)
365
+ ```
366
+
367
+ ---
368
+
369
+ ## Limitations and honest disclosures
370
+
371
+ This sample is calibrated for **structural fidelity, not bit-exact reproduction
372
+ of any specific HF registry or institutional cohort.** Specifically:
373
+
374
+ - **30-day readmission rate observed ~30-35%** vs CMS HRRP national
375
+ benchmark 22-25%. The generator's `p_30d = 0.23 × (1 + risk × 0.8)`
376
+ risk-multiplier amplifies above the base rate. Use the TEMPORAL
377
+ ORDERING (30d ≤ 90d ≤ 180d) as the structural validation, not the
378
+ absolute rate. **For absolute-rate calibration, scale to the full
379
+ product or re-fit the risk multiplier.**
380
+ - **3-year mortality observed ~10%** vs real-world HFrEF literature
381
+ 25-35% (PARADIGM-HF, EMPEROR-Reduced, DAPA-HF placebo arms). The
382
+ generator computes `mort_p = mace_p × 0.45` with `mace_p` clipped
383
+ to [0.03, 0.65], producing a mort_p ceiling of ~0.29. **The
384
+ generator under-predicts mortality for advanced HF.**
385
+ - **`bsa_m2` has a dead-code bug in the generator** (line 120 computes
386
+ BSA via Mosteller formula, line 121 immediately overwrites with
387
+ `N(1.9, 0.25)`). The overwritten N(1.9, 0.25) is what's in the
388
+ output. Don't use `bsa` for BMI/height back-calculation.
389
+ - **LBBB is not modeled** for CRT eligibility — CARE-HF / COMPANION
390
+ criteria include LVEF ≤35% + NYHA III-IV ambulatory + LBBB. Our
391
+ validation covers the first two (LVEF + NYHA); LBBB status is
392
+ absent. Add this if you need full CRT-D appropriateness classification.
393
+ - **Visit-level LVEF can drift OUT of baseline phenotype band** over
394
+ 12 quarterly visits as patients respond to GDMT — this is realistic
395
+ clinical behavior (recovered EF). Our validation checks BASELINE LVEF
396
+ in phenotype band, not visit-level. Don't filter visits by
397
+ `lvef_pct_visit` matching baseline phenotype band — you'll lose
398
+ GDMT responders.
399
+ - **`site_id` is randomly chosen from 30 generated UUIDs** —
400
+ patients within a site share no clustering structure (no
401
+ hierarchical / random-effects), no provider effects, no
402
+ geographic correlations. Treat as a nominal site label, not a
403
+ hierarchical clustering variable.
404
+ - **HFpEF treatment effect modeling is simplified.** GDMT
405
+ prescribing rates from PINNACLE are anchored to outpatient
406
+ HFrEF cohorts; HFpEF GDMT rates (`acei_arb_arni: 0.55,
407
+ betablocker: 0.60, mra: 0.25, sglt2i: 0.45`) are reasonable
408
+ but the EF response to SGLT2i in HFpEF is muted (EMPEROR-
409
+ Preserved-style effects, not EMPEROR-Reduced). Our generator
410
+ applies a uniform `+1.5 ± 1` EF delta for SGLT2i regardless
411
+ of phenotype.
412
+ - **Race / ethnicity distribution** (`60% Non-Hispanic White, 20%
413
+ Black/AA, 12% Hispanic, 5% Asian/Pacific Islander, 3% Other`)
414
+ matches general US prevalence but Black/AA HF prevalence is
415
+ ~2x higher than this in real registries. Adjust sampling if
416
+ modeling race-specific GDMT response (e.g., V-HeFT for
417
+ hydralazine-nitrate).
418
+ - **Hydralazine-nitrate flag fires at 20% of Black/AA patients**
419
+ (line 389); the generator has no separate eligibility model
420
+ (ISDN should be ACEi-intolerant or sub-target dose). Treat
421
+ as an inclusive eligibility signal.
422
+ - **Comorbidities are sampled independently** (lines 621-639) —
423
+ no realistic co-occurrence structure beyond per-phenotype
424
+ base rates. Real diabetes + obesity + sleep apnea + CKD
425
+ exhibit strong co-occurrence (cardiometabolic phenotype);
426
+ this generator treats them as independent.
427
+ - **`scipy.stats`, `faker`, `tqdm` are mentioned in the generator's
428
+ docstring** but not used in active code. No external dependencies
429
+ beyond NumPy + Pandas.
430
+ - **NYHA class distribution by phenotype** matches the design dict
431
+ (HFrEF [0.10, 0.35, 0.40, 0.15]) within ~5% sampling noise at
432
+ n=200. For tight matching, use the full product (10K patients).
433
+ - **Visit count is fixed at 12 quarterly visits** — no realistic
434
+ censoring (loss to follow-up, death before visit, etc). All
435
+ patients have all 12 visits regardless of `mortality_flag_3yr`
436
+ or `time_to_death_days`. For survival ML, use baseline TTE
437
+ variables and don't naively use visit count as risk signal.
438
+
439
+ The full HCCAR001 product addresses these by calibrated mortality and
440
+ readmission rates against real-world HFrEF/HFpEF registries, hierarchical
441
+ site / provider structure, dependent comorbidity sampling, full LBBB +
442
+ QRS duration + bundle-branch block modeling for CRT eligibility, race-
443
+ specific GDMT response heterogeneity, realistic censoring of visit
444
+ records by death/LTFU, and pre-built scenario configs (HFrEF clinical
445
+ trial simulation, HFpEF treatment-effect heterogeneity, cardiometabolic
446
+ phenotype). Contact us for the licensed commercial release.
447
+
448
+ ---
449
+
450
+ ## Companion datasets
451
+
452
+ This is the first SKU in our **Healthcare / Cardiology** vertical. Related
453
+ datasets from elsewhere in the catalog:
454
+
455
+ - [**Healthcare / Neurology**](https://huggingface.co/xpertsystems) (10 SKUs)
456
+ — synthetic neurological patient datasets covering stroke, MS, epilepsy,
457
+ Parkinson's, ALS, traumatic brain injury, dementia spectrum
458
+ - [**Insurance & Risk**](https://huggingface.co/xpertsystems) (10 SKUs) —
459
+ health insurance claims, prior authorization, risk adjustment, MLR
460
+ modeling
461
+ - [**Energy & Climate**](https://huggingface.co/xpertsystems) (8 SKUs) —
462
+ power grid, renewables, demand, O&G, smart grid, energy trading, climate
463
+ impact, consumer electricity
464
+ - [**Manufacturing**](https://huggingface.co/xpertsystems) (10 SKUs) —
465
+ reliability, quality, operations, supply chain, IIoT
466
+ - [**Oil & Gas**](https://huggingface.co/xpertsystems) (17 SKUs) — upstream,
467
+ midstream, downstream, geological / seismic, reservoir simulation
468
+
469
+ For the broader catalog, see https://huggingface.co/xpertsystems
470
+
471
+ ---
472
+
473
+ ## Citation
474
+
475
+ ```bibtex
476
+ @dataset{xpertsystems_hccar001_sample_2026,
477
+ author = {XpertSystems.ai},
478
+ title = {HCCAR001 Synthetic Heart Failure Dataset (Sample Preview)},
479
+ year = 2026,
480
+ publisher = {Hugging Face},
481
+ url = {https://huggingface.co/datasets/xpertsystems/hccar001-sample}
482
+ }
483
+ ```
484
+
485
+ ---
486
+
487
+ ## Contact
488
+
489
+ - **Web:** https://xpertsystems.ai
490
+ - **Email:** pradeep@xpertsystems.ai
491
+ - **Full product catalog:** Cardiology, Neurology, Insurance & Risk, Energy
492
+ & Climate, Manufacturing, Oil & Gas, Cybersecurity, and more
493
+
494
+ **Sample License:** CC-BY-NC-4.0 (Creative Commons Attribution-NonCommercial 4.0)
495
+ **Full product License:** Commercial — please contact for pricing.
496
+
497
+ **Important medical disclaimer:** This dataset contains SYNTHETIC patient
498
+ records only. No data was derived from any real patient, EHR archive, or
499
+ clinical registry. The dataset is intended for ML model development,
500
+ benchmarking, and education — NOT for clinical decision support, patient
501
+ counseling, or medical research conclusions. All clinical thresholds
502
+ (GDMT eligibility, ICD/CRT criteria, biomarker ranges) are sourced from
503
+ published guidelines; users are responsible for verifying against current
504
+ ACC/AHA/HFSA guidelines for clinical applications.
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