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README.md
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| 1 |
+
---
|
| 2 |
+
license: cc-by-nc-4.0
|
| 3 |
+
task_categories:
|
| 4 |
+
- tabular-classification
|
| 5 |
+
- tabular-regression
|
| 6 |
+
- time-series-forecasting
|
| 7 |
+
tags:
|
| 8 |
+
- synthetic-data
|
| 9 |
+
- healthcare
|
| 10 |
+
- cardiology
|
| 11 |
+
- hypertension
|
| 12 |
+
- htn
|
| 13 |
+
- high-blood-pressure
|
| 14 |
+
- blood-pressure-monitoring
|
| 15 |
+
- abpm
|
| 16 |
+
- ambulatory-bp-monitoring
|
| 17 |
+
- home-bp-monitoring
|
| 18 |
+
- central-aortic-pressure
|
| 19 |
+
- pulse-wave-velocity
|
| 20 |
+
- pwv
|
| 21 |
+
- augmentation-index
|
| 22 |
+
- arterial-stiffness
|
| 23 |
+
- bp-variability
|
| 24 |
+
- white-coat-hypertension
|
| 25 |
+
- masked-hypertension
|
| 26 |
+
- resistant-hypertension
|
| 27 |
+
- nocturnal-dipping
|
| 28 |
+
- non-dipper
|
| 29 |
+
- reverse-dipper
|
| 30 |
+
- ace-inhibitor
|
| 31 |
+
- arb
|
| 32 |
+
- calcium-channel-blocker
|
| 33 |
+
- ccb
|
| 34 |
+
- thiazide
|
| 35 |
+
- beta-blocker
|
| 36 |
+
- mra
|
| 37 |
+
- spironolactone
|
| 38 |
+
- antihypertensive
|
| 39 |
+
- medication-adherence
|
| 40 |
+
- bp-response
|
| 41 |
+
- side-effects
|
| 42 |
+
- pill-burden
|
| 43 |
+
- lifestyle-modification
|
| 44 |
+
- dash-diet
|
| 45 |
+
- sodium-intake
|
| 46 |
+
- physical-activity
|
| 47 |
+
- mets
|
| 48 |
+
- sleep-quality
|
| 49 |
+
- osa
|
| 50 |
+
- obstructive-sleep-apnea
|
| 51 |
+
- ascvd
|
| 52 |
+
- ascvd-pooled-cohort
|
| 53 |
+
- framingham-risk
|
| 54 |
+
- pooled-cohort-equation
|
| 55 |
+
- mace
|
| 56 |
+
- major-adverse-cardiovascular-event
|
| 57 |
+
- mi-prediction
|
| 58 |
+
- stroke-prediction
|
| 59 |
+
- hf-hospitalization
|
| 60 |
+
- atrial-fibrillation
|
| 61 |
+
- cv-death
|
| 62 |
+
- lvh
|
| 63 |
+
- left-ventricular-hypertrophy
|
| 64 |
+
- lv-mass-index
|
| 65 |
+
- e-e-prime
|
| 66 |
+
- diastolic-dysfunction
|
| 67 |
+
- carotid-imt
|
| 68 |
+
- carotid-plaque
|
| 69 |
+
- retinopathy
|
| 70 |
+
- microalbuminuria
|
| 71 |
+
- macroalbuminuria
|
| 72 |
+
- uacr
|
| 73 |
+
- ckd
|
| 74 |
+
- kdigo
|
| 75 |
+
- egfr
|
| 76 |
+
- ckd-epi
|
| 77 |
+
- ckd-stage
|
| 78 |
+
- hs-crp
|
| 79 |
+
- bnp
|
| 80 |
+
- troponin
|
| 81 |
+
- acc-aha-2017
|
| 82 |
+
- esh-2018
|
| 83 |
+
- abpm-task-force
|
| 84 |
+
- carey-resistant-htn
|
| 85 |
+
- aha-acc-pce-2013
|
| 86 |
+
- longitudinal-ehr
|
| 87 |
+
- ehr-synthetic
|
| 88 |
+
- clinical-trial-simulation
|
| 89 |
+
pretty_name: HCCAR003 — Synthetic Hypertension & Cardiovascular Risk Dataset (Sample)
|
| 90 |
+
size_categories:
|
| 91 |
+
- 1K<n<10K
|
| 92 |
+
configs:
|
| 93 |
+
- config_name: default
|
| 94 |
+
data_files: hccar003_dataset.parquet
|
| 95 |
+
---
|
| 96 |
+
|
| 97 |
+
# HCCAR003 — Synthetic Hypertension & Cardiovascular Risk Dataset (Sample Preview)
|
| 98 |
+
|
| 99 |
+
**XpertSystems.ai | Synthetic Data Factory | Healthcare / Cardiology Vertical**
|
| 100 |
+
|
| 101 |
+
A **longitudinal hypertension cohort dataset** with quarterly visit-level
|
| 102 |
+
records spanning **7 clinical modules**: BP monitoring (office, home, ABPM
|
| 103 |
+
24hr/day/night with dipping pattern, central aortic, pulse wave velocity,
|
| 104 |
+
augmentation index, BP variability), antihypertensive medications (up to
|
| 105 |
+
4 drug slots, 8 drug classes — ACEi, ARB, CCB, Thiazide, Beta-blocker,
|
| 106 |
+
Alpha-blocker, MRA), lifestyle factors (DASH diet, dietary sodium,
|
| 107 |
+
physical activity METs, sleep, smoking, alcohol, stress), biomarkers
|
| 108 |
+
(full lipid panel, hs-CRP, creatinine, eGFR with KDIGO CKD stage, UACR
|
| 109 |
+
with microalbuminuria/macroalbuminuria, electrolytes, glucose, HbA1c,
|
| 110 |
+
BNP, troponin, ASCVD 10y risk, Framingham), end-organ damage (LVH, LV
|
| 111 |
+
mass index, LVEF, E/e' ratio, carotid IMT, plaque, retinopathy grade,
|
| 112 |
+
white matter lesion volume, lacunar infarcts), and **MACE outcomes**
|
| 113 |
+
(MI, ischemic / hemorrhagic stroke, TIA, HF hospitalization, AF new
|
| 114 |
+
onset, CV death, all-cause death, study dropout).
|
| 115 |
+
|
| 116 |
+
Calibrated benchmark-first against **ACC/AHA 2017 Hypertension Guidelines**
|
| 117 |
+
(Whelton et al.), **ACC/AHA 2013 Pooled Cohort Equations** (Goff et al.),
|
| 118 |
+
**KDIGO 2012 CKD Classification**, **ABPM Task Force / ESH 2013
|
| 119 |
+
Recommendations**, **AHA/ACC Resistant Hypertension Scientific Statement
|
| 120 |
+
(Carey et al. 2018)**, and **ESH/ESC 2018 Hypertension Guidelines**.
|
| 121 |
+
|
| 122 |
+
This is the **sample preview** — 150 patients × ~12 quarterly visits over
|
| 123 |
+
3 years (~1,800 visit records, ~1.1 MB). The full product covers 10,000+
|
| 124 |
+
patients × full 10-year follow-up (40 quarterly visits) with extended
|
| 125 |
+
medication titration histories, multi-cuff measurement protocols, and
|
| 126 |
+
pre-built scenario configs for SPRINT-style intensive vs standard BP
|
| 127 |
+
target trials, salt-sensitive hypertension studies, and resistant
|
| 128 |
+
hypertension subgroup analysis.
|
| 129 |
+
|
| 130 |
+
---
|
| 131 |
+
|
| 132 |
+
## Dataset summary
|
| 133 |
+
|
| 134 |
+
| Table | Rows (sample) | What it contains |
|
| 135 |
+
|---|---:|---|
|
| 136 |
+
| `hccar003_dataset` | 1,747 | One row per patient × visit. 99 features across 7 clinical modules (demographics carried forward + BP monitoring + medications + lifestyle + biomarkers + end-organ damage + MACE outcomes). 150 unique patients with up to 12 quarterly visits each (some patients drop out due to death or withdrawal) |
|
| 137 |
+
|
| 138 |
+
Provided in both **CSV** and **Parquet**. Aggregate to patient-level via
|
| 139 |
+
`groupby('patient_id')` for cross-sectional analysis.
|
| 140 |
+
|
| 141 |
+
---
|
| 142 |
+
|
| 143 |
+
## Calibration sources
|
| 144 |
+
|
| 145 |
+
All ten validation metrics target named clinical / regulatory standards:
|
| 146 |
+
|
| 147 |
+
- **ACC/AHA 2017 Hypertension Guidelines** (Whelton et al. 2018) — HTN
|
| 148 |
+
stage classification (Normal, Elevated, Stage 1, Stage 2, Crisis)
|
| 149 |
+
- **ACC/AHA 2013 Pooled Cohort Equations** (Goff et al. 2014) — 10-year
|
| 150 |
+
ASCVD risk (race/sex-specific, baseline column included with known
|
| 151 |
+
calibration issues — see Limitations)
|
| 152 |
+
- **KDIGO 2012 CKD Classification** — eGFR-based G1-G5 staging,
|
| 153 |
+
UACR-based A1-A3 albuminuria categories
|
| 154 |
+
- **ABPM Task Force / ESH 2013** (O'Brien et al. 2013) — ambulatory
|
| 155 |
+
blood pressure monitoring definitions, dipping pattern classification,
|
| 156 |
+
masked hypertension criteria
|
| 157 |
+
- **AHA/ACC Resistant Hypertension Scientific Statement** (Carey et al.
|
| 158 |
+
2018) — resistant HTN = SBP ≥130/80 on ≥3 antihypertensives
|
| 159 |
+
- **ESH/ESC 2018 Hypertension Guidelines** (Williams et al. 2018) —
|
| 160 |
+
European HTN management framework
|
| 161 |
+
- **CKD-EPI 2009** (Levey et al. 2009) — eGFR calculation (note: the
|
| 162 |
+
generator uses the OLD race-coefficient version; the 2021 NKF-ASN
|
| 163 |
+
refit removed the race coefficient. See Limitations.)
|
| 164 |
+
- **Survival analysis monotonicity** — CV death ⊆ all-cause death
|
| 165 |
+
|
| 166 |
+
---
|
| 167 |
+
|
| 168 |
+
## Validation scorecard (seed = 42)
|
| 169 |
+
|
| 170 |
+
10/10 PASS · **Grade A+ (100%)** across all six canonical seeds (42, 7, 123, 2024, 99, 1).
|
| 171 |
+
|
| 172 |
+
| # | Metric | Observed | Target | Tol | Type | Source |
|
| 173 |
+
|---|---|---:|---:|---:|---|---|
|
| 174 |
+
| 1 | `pulse_pressure_equals_sbp_minus_dbp_rate` | 1.000 | 0.99 | ±0.01 | FLOOR | Hemodynamic identity |
|
| 175 |
+
| 2 | `map_equals_dbp_plus_pp_third_rate` | 1.000 | 0.99 | ±0.01 | FLOOR | Hemodynamic identity |
|
| 176 |
+
| 3 | `ckd_stage_matches_kdigo_egfr_rate` | 0.999 | 0.99 | ±0.01 | FLOOR | KDIGO 2012 |
|
| 177 |
+
| 4 | `albuminuria_flags_match_uacr_bands_rate` | 1.000 | 0.99 | ±0.01 | FLOOR | KDIGO ACR thresholds |
|
| 178 |
+
| 5 | `abpm_dipping_pattern_matches_dip_pct_rate` | 0.991 | 0.99 | ±0.01 | FLOOR | ABPM Task Force / ESH 2013 |
|
| 179 |
+
| 6 | `resistant_htn_requires_3_drugs_and_sbp_130_rate` | 1.000 | 0.99 | ±0.01 | FLOOR | Carey et al. 2018 |
|
| 180 |
+
| 7 | `masked_htn_definition_match_rate` | 1.000 | 0.99 | ±0.01 | FLOOR | ABPM Task Force |
|
| 181 |
+
| 8 | `cv_death_implies_all_cause_death_rate` | 1.000 | 0.99 | ±0.01 | FLOOR | Survival monotonicity |
|
| 182 |
+
| 9 | `mace_event_flag_matches_event_type_rate` | 1.000 | 0.99 | ±0.01 | FLOOR | MACE composite endpoint |
|
| 183 |
+
| 10 | `bp_in_physiologic_bounds_rate` | 1.000 | 0.99 | ±0.01 | FLOOR | Physiologic plausibility |
|
| 184 |
+
|
| 185 |
+
---
|
| 186 |
+
|
| 187 |
+
## Schema highlights (99 cols)
|
| 188 |
+
|
| 189 |
+
### Identity & demographics (8 cols, carried per visit)
|
| 190 |
+
`patient_id` (HC-CAR-XXXXXX), `visit_number` (1-12), `visit_date`,
|
| 191 |
+
`years_from_baseline`, `age_at_visit`, `sex` (Male / Female),
|
| 192 |
+
`race_ethnicity` (NonHispanic_White / NonHispanic_Black / Hispanic /
|
| 193 |
+
Asian / Other), `htn_stage_baseline` (Normal / Elevated / Stage1_HTN /
|
| 194 |
+
Stage2_HTN / Crisis).
|
| 195 |
+
|
| 196 |
+
### BP monitoring (19 cols)
|
| 197 |
+
`sbp_office_mmhg`, `dbp_office_mmhg`, `pp_office_mmhg`, `map_office_mmhg`,
|
| 198 |
+
`sbp_home_avg_mmhg`, `dbp_home_avg_mmhg`, `abpm_sbp_24hr_mmhg`,
|
| 199 |
+
`abpm_dbp_24hr_mmhg`, `abpm_sbp_daytime_mmhg`, `abpm_sbp_nighttime_mmhg`,
|
| 200 |
+
`abpm_dipping_pct`, `abpm_dipping_pattern` (Reverse_dipper / Non-dipper /
|
| 201 |
+
Dipper / Extreme_dipper), `central_aortic_sbp_mmhg`,
|
| 202 |
+
`pulse_wave_velocity_ms`, `augmentation_index_pct`, `bp_variability_sd_sbp`,
|
| 203 |
+
`white_coat_effect_mmhg`, `white_coat_flag`, `masked_hypertension_flag`.
|
| 204 |
+
|
| 205 |
+
### Medications (12 cols)
|
| 206 |
+
`drug_class_{1-4}`, `drug_name_{1-3}`, `drug_dose_1`,
|
| 207 |
+
`n_antihypertensive_drugs` (0-4), `medication_adherence_pct`,
|
| 208 |
+
`bp_response_sbp_mmhg`, `resistant_htn_flag`, `side_effect_code`
|
| 209 |
+
(Dry_Cough / Peripheral_Edema / Hypokalemia / Bradycardia /
|
| 210 |
+
Orthostatic_Hypotension / Hyperkalemia / None), `pill_burden_score`.
|
| 211 |
+
|
| 212 |
+
### Lifestyle (8 cols)
|
| 213 |
+
`bmi_kg_m2`, `dietary_sodium_mg_day`, `dash_diet_score`,
|
| 214 |
+
`physical_activity_mets_hr_wk`, `sleep_hours_night`, `smoking_status`
|
| 215 |
+
(Never / Former / Current), `alcohol_drinks_week`, `stress_score`.
|
| 216 |
+
|
| 217 |
+
### Biomarkers (22 cols)
|
| 218 |
+
`total_cholesterol_mg_dl`, `ldl_cholesterol_mg_dl`, `hdl_cholesterol_mg_dl`,
|
| 219 |
+
`triglycerides_mg_dl`, `non_hdl_cholesterol_mg_dl`, `hs_crp_mg_l`,
|
| 220 |
+
`creatinine_mg_dl`, `egfr_ml_min_1_73m2`, `uacr_mg_g`, `ckd_stage`
|
| 221 |
+
(G1 / G2 / G3a / G3b / G4 / G5), `bun_mg_dl`, `potassium_meq_l`,
|
| 222 |
+
`sodium_meq_l`, `glucose_fasting_mg_dl`, `hba1c_pct`, `uric_acid_mg_dl`,
|
| 223 |
+
`bnp_pg_ml`, `troponin_i_ng_l`, `ascvd_10yr_risk_pct`,
|
| 224 |
+
`framingham_risk_score_pct`, `microalbuminuria_flag`,
|
| 225 |
+
`macroalbuminuria_flag`.
|
| 226 |
+
|
| 227 |
+
### End-organ damage (9 cols)
|
| 228 |
+
`lvh_flag`, `lv_mass_index_g_m2`, `lvef_pct`, `e_e_prime_ratio`,
|
| 229 |
+
`carotid_imt_mm`, `carotid_plaque_flag`, `retinopathy_grade` (0-4),
|
| 230 |
+
`wml_volume_ml`, `lacunar_infarct_flag`.
|
| 231 |
+
|
| 232 |
+
### MACE outcomes (11 cols)
|
| 233 |
+
`mace_event_flag`, `mace_event_type` (MI / Stroke_Ischemic /
|
| 234 |
+
Stroke_Hemorrhagic / TIA / HF_Hospitalization / AF_New_Onset / CV_Death /
|
| 235 |
+
Non_CV_Death / None), `mi_flag`, `stroke_flag`, `stroke_type`,
|
| 236 |
+
`hf_hospitalization_flag`, `af_new_onset_flag`, `cardiovascular_death_flag`,
|
| 237 |
+
`all_cause_death_flag`, `study_dropout_flag`, `dropout_reason` (Death /
|
| 238 |
+
Withdrawal / None).
|
| 239 |
+
|
| 240 |
+
### Comorbidities (7 cols, carried forward)
|
| 241 |
+
`diabetes_flag`, `dyslipidemia_flag`, `osa_flag`, `statin_use_flag`,
|
| 242 |
+
`aspirin_use_flag`, `family_history_htn_flag`,
|
| 243 |
+
`charlson_comorbidity_index`.
|
| 244 |
+
|
| 245 |
+
---
|
| 246 |
+
|
| 247 |
+
## Suggested use cases
|
| 248 |
+
|
| 249 |
+
- **BP control prediction** — train classifiers/regressors on
|
| 250 |
+
`sbp_office_mmhg` and `resistant_htn_flag` from baseline + medication
|
| 251 |
+
+ lifestyle features
|
| 252 |
+
- **ABPM interpretation ML** — predict dipping pattern, masked HTN from
|
| 253 |
+
office BP, home BP, and patient features; useful for ABPM-replacement
|
| 254 |
+
algorithms
|
| 255 |
+
- **Medication response prediction** — model `bp_response_sbp_mmhg`
|
| 256 |
+
given drug class combinations and patient characteristics (uplift
|
| 257 |
+
modeling for personalized antihypertensive selection)
|
| 258 |
+
- **Resistant HTN cohort identification** — classifier for
|
| 259 |
+
`resistant_htn_flag` for utilization analytics
|
| 260 |
+
- **Antihypertensive adherence ML** — predict
|
| 261 |
+
`medication_adherence_pct` from pill burden, side effects, SES, age
|
| 262 |
+
- **ASCVD risk recalibration** — train improved 10-year ASCVD models
|
| 263 |
+
to compare against ACC/AHA PCE (note: the included
|
| 264 |
+
`ascvd_10yr_risk_pct` has known calibration issues — useful for
|
| 265 |
+
derivation studies that explicitly correct PCE bugs)
|
| 266 |
+
- **MACE survival ML** — Cox / DeepSurv / random survival forests on
|
| 267 |
+
the MACE outcomes (aggregate per-visit flags to patient level for
|
| 268 |
+
TTE analysis)
|
| 269 |
+
- **End-organ damage progression** — model `lvh_flag`, `carotid_imt_mm`,
|
| 270 |
+
`wml_volume_ml` trajectories given longitudinal BP control
|
| 271 |
+
- **CKD progression in HTN** — model `egfr_ml_min_1_73m2` decline
|
| 272 |
+
trajectories; useful for predicting CKD-G3 → G4 transitions
|
| 273 |
+
- **White coat / masked HTN detection** — classifier for office vs
|
| 274 |
+
ambulatory discrepancy; useful for diagnostic workflow automation
|
| 275 |
+
- **Salt sensitivity studies** — use `dietary_sodium_mg_day` and
|
| 276 |
+
individual BP response to identify salt-sensitive phenotypes
|
| 277 |
+
- **Dipping pattern ML** — predict nocturnal dipping pattern
|
| 278 |
+
(Reverse / Non / Normal / Extreme) from office BP, age, OSA,
|
| 279 |
+
comorbidities; useful for ABPM-free phenotyping
|
| 280 |
+
- **Treatment intensification timing ML** — predict when next drug
|
| 281 |
+
should be added from BP trajectory + current regimen
|
| 282 |
+
- **Quality improvement / HEDIS analytics** — BP control rate
|
| 283 |
+
measurement, medication intensification audit (HEDIS Controlling
|
| 284 |
+
High Blood Pressure metric)
|
| 285 |
+
|
| 286 |
+
---
|
| 287 |
+
|
| 288 |
+
## Loading examples
|
| 289 |
+
|
| 290 |
+
```python
|
| 291 |
+
from datasets import load_dataset
|
| 292 |
+
|
| 293 |
+
ds = load_dataset("xpertsystems/hccar003-sample", split="train")
|
| 294 |
+
print(ds.shape)
|
| 295 |
+
```
|
| 296 |
+
|
| 297 |
+
```python
|
| 298 |
+
import pandas as pd
|
| 299 |
+
from huggingface_hub import hf_hub_download
|
| 300 |
+
|
| 301 |
+
df = pd.read_parquet(hf_hub_download(
|
| 302 |
+
"xpertsystems/hccar003-sample", "hccar003_dataset.parquet",
|
| 303 |
+
repo_type="dataset",
|
| 304 |
+
))
|
| 305 |
+
|
| 306 |
+
# HTN stage distribution
|
| 307 |
+
print(df.groupby("patient_id")["htn_stage_baseline"].first()
|
| 308 |
+
.value_counts(normalize=True).round(3))
|
| 309 |
+
```
|
| 310 |
+
|
| 311 |
+
```python
|
| 312 |
+
# BP trajectory by HTN stage
|
| 313 |
+
import pandas as pd
|
| 314 |
+
from huggingface_hub import hf_hub_download
|
| 315 |
+
|
| 316 |
+
df = pd.read_parquet(hf_hub_download(
|
| 317 |
+
"xpertsystems/hccar003-sample", "hccar003_dataset.parquet",
|
| 318 |
+
repo_type="dataset",
|
| 319 |
+
))
|
| 320 |
+
|
| 321 |
+
trajectory = (
|
| 322 |
+
df.groupby(["htn_stage_baseline", "visit_number"])["sbp_office_mmhg"]
|
| 323 |
+
.mean().unstack(level=0).round(1)
|
| 324 |
+
)
|
| 325 |
+
print(trajectory.head(12))
|
| 326 |
+
```
|
| 327 |
+
|
| 328 |
+
```python
|
| 329 |
+
# Resistant HTN identification + drug regimens
|
| 330 |
+
import pandas as pd
|
| 331 |
+
from huggingface_hub import hf_hub_download
|
| 332 |
+
|
| 333 |
+
df = pd.read_parquet(hf_hub_download(
|
| 334 |
+
"xpertsystems/hccar003-sample", "hccar003_dataset.parquet",
|
| 335 |
+
repo_type="dataset",
|
| 336 |
+
))
|
| 337 |
+
|
| 338 |
+
# Patients with resistant HTN at ANY visit
|
| 339 |
+
resistant_pts = df.loc[df["resistant_htn_flag"] == 1, "patient_id"].unique()
|
| 340 |
+
print(f"Resistant HTN patients: {len(resistant_pts)} / {df['patient_id'].nunique()}")
|
| 341 |
+
|
| 342 |
+
# Their typical drug regimens (drug_class_1 distribution)
|
| 343 |
+
resist_df = df[df["patient_id"].isin(resistant_pts)]
|
| 344 |
+
print(resist_df["drug_class_1"].value_counts().head())
|
| 345 |
+
```
|
| 346 |
+
|
| 347 |
+
```python
|
| 348 |
+
# Aggregate MACE outcomes to patient level
|
| 349 |
+
import pandas as pd
|
| 350 |
+
from huggingface_hub import hf_hub_download
|
| 351 |
+
|
| 352 |
+
df = pd.read_parquet(hf_hub_download(
|
| 353 |
+
"xpertsystems/hccar003-sample", "hccar003_dataset.parquet",
|
| 354 |
+
repo_type="dataset",
|
| 355 |
+
))
|
| 356 |
+
|
| 357 |
+
# Per-patient MACE summary (per-visit flags need aggregation)
|
| 358 |
+
patient_mace = df.groupby("patient_id").agg(
|
| 359 |
+
any_mi=("mi_flag", "max"),
|
| 360 |
+
any_stroke=("stroke_flag", "max"),
|
| 361 |
+
any_hf=("hf_hospitalization_flag", "max"),
|
| 362 |
+
any_af=("af_new_onset_flag", "max"),
|
| 363 |
+
cv_death=("cardiovascular_death_flag", "max"),
|
| 364 |
+
all_cause_death=("all_cause_death_flag", "max"),
|
| 365 |
+
follow_up_yrs=("years_from_baseline", "max"),
|
| 366 |
+
).round(3)
|
| 367 |
+
|
| 368 |
+
print("Patient-level event rates:")
|
| 369 |
+
print(patient_mace.mean().round(3))
|
| 370 |
+
```
|
| 371 |
+
|
| 372 |
+
```python
|
| 373 |
+
# ABPM dipping pattern distribution
|
| 374 |
+
import pandas as pd
|
| 375 |
+
from huggingface_hub import hf_hub_download
|
| 376 |
+
|
| 377 |
+
df = pd.read_parquet(hf_hub_download(
|
| 378 |
+
"xpertsystems/hccar003-sample", "hccar003_dataset.parquet",
|
| 379 |
+
repo_type="dataset",
|
| 380 |
+
))
|
| 381 |
+
|
| 382 |
+
print("Dipping pattern distribution by HTN stage:")
|
| 383 |
+
print(pd.crosstab(df["htn_stage_baseline"], df["abpm_dipping_pattern"],
|
| 384 |
+
normalize="index").round(3))
|
| 385 |
+
```
|
| 386 |
+
|
| 387 |
+
---
|
| 388 |
+
|
| 389 |
+
## Limitations and honest disclosures
|
| 390 |
+
|
| 391 |
+
This sample is calibrated for **structural fidelity, not bit-exact reproduction
|
| 392 |
+
of any specific HTN cohort registry.** Specifically:
|
| 393 |
+
|
| 394 |
+
- **The included Pooled Cohort Equation (`ascvd_10yr_risk_pct`) is BUGGY.**
|
| 395 |
+
The generator's PCE implementation (lines 122-153) has multiple errors:
|
| 396 |
+
(a) White Male branch uses `1.764` for both bp_treated and untreated,
|
| 397 |
+
removing treatment effect; (b) White Female has a misplaced
|
| 398 |
+
`-29.799*1` term; (c) Black Male is missing the published intercept;
|
| 399 |
+
(d) Black Female has implausible coefficients on ln_sbp (29.2907 vs
|
| 400 |
+
published 0.295). **Result: ASCVD risk values saturate at clip ceiling
|
| 401 |
+
(75%) for ~93% of patients and at clip floor (1%) for Black Males.**
|
| 402 |
+
Use the column only as a relative-ordering signal, not for absolute
|
| 403 |
+
10-year ASCVD estimation. For accurate ASCVD risk, recompute from
|
| 404 |
+
age, sex, race, total cholesterol, HDL, SBP, BP treatment flag,
|
| 405 |
+
diabetes, smoking using the published formula
|
| 406 |
+
(Goff et al. 2014).
|
| 407 |
+
- **eGFR uses the OLD 2009 CKD-EPI formula with race coefficient**
|
| 408 |
+
(line 216-217: `egfr *= 1.159 if Black`). The 2021 NKF-ASN refit
|
| 409 |
+
REMOVED the race coefficient. If you need the modern formula,
|
| 410 |
+
recompute from `creatinine_mg_dl`, `age_at_visit`, `sex` without
|
| 411 |
+
the race multiplier.
|
| 412 |
+
- **`carotid_plaque_flag` formula bug**: `int(RNG.random() < (0.05 + 0.01*age - 0.5))`
|
| 413 |
+
effectively gives ZERO carotid plaque to patients under age 45 (the
|
| 414 |
+
probability term goes negative). For full plaque modeling, use the
|
| 415 |
+
full product or augment with separate carotid imaging modules.
|
| 416 |
+
- **MACE per-visit flags fire on only ONE visit per patient** (the
|
| 417 |
+
visit within 0.13 years of `event_time`). They are NOT cumulative —
|
| 418 |
+
the flag does not carry forward after the event. **For patient-level
|
| 419 |
+
MACE prediction, aggregate via `groupby('patient_id').max()` on the
|
| 420 |
+
flag columns** (see "Loading examples" above). Time-to-event must be
|
| 421 |
+
derived from the visit_number × 0.25 (quarterly) offset.
|
| 422 |
+
- **`af_new_onset_flag` can fire from MACE event AND from a separate
|
| 423 |
+
stochastic check** (line 480): `int(mace_type == 'AF_New_Onset' or
|
| 424 |
+
(yrs > 5 and sbp_off > 160 and random < 0.005))`. So AF can occur
|
| 425 |
+
outside of the formal MACE event window — by design, reflecting that
|
| 426 |
+
AF is sometimes diagnosed incidentally.
|
| 427 |
+
- **`_dropout_at` reference in main loop** (line 646) checks a dictionary
|
| 428 |
+
key that's never set by `generate_patient_baseline`. The branch is
|
| 429 |
+
dead code; dropout actually fires via `study_dropout_flag` only.
|
| 430 |
+
Cosmetic side-effect.
|
| 431 |
+
- **Mean SBP ~144 mmHg, mean DBP ~97 mmHg** in this sample — higher
|
| 432 |
+
than typical real-world HTN cohorts (~135/85) because the HTN stage
|
| 433 |
+
distribution skews toward Stage 1/2 (~55% of patients). The
|
| 434 |
+
generator's stage probabilities `[Normal: 15%, Elevated: 20%,
|
| 435 |
+
Stage1: 30%, Stage2: 25%, Crisis: 10%]` produce a hypertension-
|
| 436 |
+
enriched cohort by design (suitable for HTN clinical trials, not
|
| 437 |
+
general population epidemiology).
|
| 438 |
+
- **Race/ethnicity SBP offsets** (line 106-109): Black patients have
|
| 439 |
+
+6 mmHg SBP offset, Asian -2 mmHg. These match published trial
|
| 440 |
+
observations (e.g., AASK, ALLHAT) but are NOT a complete model of
|
| 441 |
+
hypertension disparities — they encode only the magnitude offset, not
|
| 442 |
+
the underlying mechanisms (RAAS responsiveness, salt sensitivity,
|
| 443 |
+
vascular dysfunction).
|
| 444 |
+
- **Visit dropout is independent of clinical state** (line 485:
|
| 445 |
+
`dropout_flag = int(dead_v or (random < 0.003))`). Real HTN cohort
|
| 446 |
+
dropout correlates with poor BP control, adverse drug effects, and
|
| 447 |
+
SES. Treat the sample as informatively-censored data only if you
|
| 448 |
+
augment with realistic dropout mechanisms.
|
| 449 |
+
- **Comorbidities are independent draws** (lines 188-194: dm, dys, ckd,
|
| 450 |
+
osa) — no realistic co-occurrence beyond per-flag base rates. Real
|
| 451 |
+
cardiometabolic clustering (diabetes + dyslipidemia + obesity + CKD)
|
| 452 |
+
is much tighter than the generator produces.
|
| 453 |
+
- **`scipy.stats` is imported but unused** in active generator code.
|
| 454 |
+
No external compute dependencies beyond numpy + pandas + tqdm. The
|
| 455 |
+
scipy distributions (norm, beta, lognorm, weibull_min) appear in the
|
| 456 |
+
import block but never get called.
|
| 457 |
+
- **Masked HTN observed at 0.3-0.5%** in sample — much lower than the
|
| 458 |
+
10-15% prevalence reported in clinical literature. Generator's
|
| 459 |
+
`wc_effect ~ N(8, 6)` and white_coat→office subtraction produces
|
| 460 |
+
predominantly white-coat phenotype (office > home) rather than
|
| 461 |
+
masked (home > office). For masked HTN ML research, augment with
|
| 462 |
+
inverted white-coat scenarios from the full product.
|
| 463 |
+
- **Visit count varies by patient** — some patients have 12 visits,
|
| 464 |
+
some have fewer due to dropout. Use `groupby('patient_id').size()`
|
| 465 |
+
to check follow-up duration per patient. Treat as unbalanced panel
|
| 466 |
+
data.
|
| 467 |
+
- **Drug-drug interactions and titration are simplified.** The drug
|
| 468 |
+
regimen is fixed at baseline (4 slots, randomly chosen from 7
|
| 469 |
+
classes); no realistic titration logic, no switching due to side
|
| 470 |
+
effects, no addition due to inadequate BP response. For
|
| 471 |
+
pharmacotherapy intensification ML, use the full product.
|
| 472 |
+
|
| 473 |
+
The full HCCAR003 product addresses these by corrected ACC/AHA PCE
|
| 474 |
+
implementation, full 2021 CKD-EPI refit, complete carotid plaque
|
| 475 |
+
modeling, MACE flag carry-forward for survival analysis, realistic
|
| 476 |
+
medication titration trajectories, dependent comorbidity sampling,
|
| 477 |
+
and pre-built scenario configs (SPRINT-style intensive vs standard,
|
| 478 |
+
salt-sensitive HTN, resistant HTN subgroup). Contact us for the
|
| 479 |
+
licensed commercial release.
|
| 480 |
+
|
| 481 |
+
---
|
| 482 |
+
|
| 483 |
+
## Companion datasets
|
| 484 |
+
|
| 485 |
+
This is the third SKU in our **Healthcare / Cardiology** vertical. Related
|
| 486 |
+
datasets from elsewhere in the catalog:
|
| 487 |
+
|
| 488 |
+
- [**HCCAR001**](https://huggingface.co/datasets/xpertsystems/hccar001-sample)
|
| 489 |
+
Heart Failure Dataset — chronic HF longitudinal records with GDMT,
|
| 490 |
+
device therapy, hospitalization, 12 quarterly visits
|
| 491 |
+
- [**HCCAR002**](https://huggingface.co/datasets/xpertsystems/hccar002-sample)
|
| 492 |
+
Acute Myocardial Infarction Dataset — STEMI/NSTEMI/UA with serial
|
| 493 |
+
troponin kinetics, intervention timing, in-hospital outcomes
|
| 494 |
+
- [**HCCAR003**](https://huggingface.co/datasets/xpertsystems/hccar003-sample)
|
| 495 |
+
Hypertension Dataset (you are here) — longitudinal HTN cohort with
|
| 496 |
+
ABPM, GDMT, MACE outcomes
|
| 497 |
+
- [**Healthcare / Neurology**](https://huggingface.co/xpertsystems) (10 SKUs)
|
| 498 |
+
- [**Insurance & Risk**](https://huggingface.co/xpertsystems) (10 SKUs)
|
| 499 |
+
- [**Energy & Climate**](https://huggingface.co/xpertsystems) (8 SKUs)
|
| 500 |
+
- [**Manufacturing**](https://huggingface.co/xpertsystems) (10 SKUs)
|
| 501 |
+
- [**Oil & Gas**](https://huggingface.co/xpertsystems) (17 SKUs)
|
| 502 |
+
|
| 503 |
+
**Cardiology pairing**: HCCAR001 + HCCAR002 + HCCAR003 covers the full
|
| 504 |
+
HTN→AMI→HF clinical trajectory. Hypertension is the leading modifiable
|
| 505 |
+
risk factor for AMI (HCCAR002) and HFpEF (HCCAR001 phenotype).
|
| 506 |
+
|
| 507 |
+
For the broader catalog, see https://huggingface.co/xpertsystems
|
| 508 |
+
|
| 509 |
+
---
|
| 510 |
+
|
| 511 |
+
## Citation
|
| 512 |
+
|
| 513 |
+
```bibtex
|
| 514 |
+
@dataset{xpertsystems_hccar003_sample_2026,
|
| 515 |
+
author = {XpertSystems.ai},
|
| 516 |
+
title = {HCCAR003 Synthetic Hypertension \& Cardiovascular Risk Dataset (Sample Preview)},
|
| 517 |
+
year = 2026,
|
| 518 |
+
publisher = {Hugging Face},
|
| 519 |
+
url = {https://huggingface.co/datasets/xpertsystems/hccar003-sample}
|
| 520 |
+
}
|
| 521 |
+
```
|
| 522 |
+
|
| 523 |
+
---
|
| 524 |
+
|
| 525 |
+
## Contact
|
| 526 |
+
|
| 527 |
+
- **Web:** https://xpertsystems.ai
|
| 528 |
+
- **Email:** pradeep@xpertsystems.ai
|
| 529 |
+
- **Full product catalog:** Cardiology, Neurology, Insurance & Risk, Energy
|
| 530 |
+
& Climate, Manufacturing, Oil & Gas, Cybersecurity, and more
|
| 531 |
+
|
| 532 |
+
**Sample License:** CC-BY-NC-4.0 (Creative Commons Attribution-NonCommercial 4.0)
|
| 533 |
+
**Full product License:** Commercial — please contact for pricing.
|
| 534 |
+
|
| 535 |
+
**Important medical disclaimer:** This dataset contains SYNTHETIC patient
|
| 536 |
+
records only. No data was derived from any real patient, EHR archive,
|
| 537 |
+
or clinical registry. The dataset is intended for ML model development,
|
| 538 |
+
benchmarking, and education — NOT for clinical decision support, patient
|
| 539 |
+
counseling, or medical research conclusions. All clinical thresholds
|
| 540 |
+
(HTN stage, resistant HTN, ABPM dipping pattern, KDIGO CKD stages) are
|
| 541 |
+
sourced from published guidelines; users are responsible for verifying
|
| 542 |
+
against current ACC/AHA/ESC/KDIGO guidelines for clinical applications.
|
| 543 |
+
The included Pooled Cohort Equation implementation has known
|
| 544 |
+
calibration issues — see Limitations.
|
hccar003_dataset.csv
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|
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hccar003_dataset.parquet
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|
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version https://git-lfs.github.com/spec/v1
|
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oid sha256:6ad1568de817791837b332e52c9a7721b71d86f64f21caead511335fd2a5a9cd
|
| 3 |
+
size 278474
|