accession stringlengths 6 10 | sequence stringlengths 6 2.3k | function stringlengths 15 1.4k |
|---|---|---|
P52952 | <M><F><P><S><P><A><L><T><P><T><P><F><S><V><K><D><I><L><N><L><E><Q><Q><Q><R><S><L><A><A><A><G><E><L><S><A><R><L><E><A><T><L><A><P><S><S><C><M><L><A><A><F><K><P><E><A><Y><A><G><P><E><A><A><A><P><G><L><P><E><L><R><A><E><L><G><R><A><P><S><P><A><K><C><A><S><A><F><P><A><A><P><A><F><Y><P><R><A><Y><S><D><P><D><P><A><K><D><P><R... | Transcription factor required for the development of the heart and the spleen. May cooperate with TBX2 to negatively modulate expression of NPPA/ANF in the atrioventricular canal. Binds to the core DNA motif of NPPA promoter. Together with PBX1, required for spleen development through a mechanism that involves CDKN2B r... |
Q969K3 | <M><K><A><G><A><T><S><M><W><A><S><C><C><G><L><L><N><E><V><M><G><T><G><A><V><R><G><Q><Q><S><A><F><A><G><A><T><G><P><F><R><F><T><P><N><P><E><F><S><T><Y><P><P><A><A><T><E><G><P><N><I><V><C><K><A><C><G><L><S><F><S><V><F><R><K><K><H><V><C><C><D><C><K><K><D><F><C><S><V><C><S><V><L><Q><E><N><L><R><R><C><S><T><C><H><L><L><Q><E... | E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the e... |
P33992 | <M><S><G><F><D><D><P><G><I><F><Y><S><D><S><F><G><G><D><A><Q><A><D><E><G><Q><A><R><K><S><Q><L><Q><R><R><F><K><E><F><L><R><Q><Y><R><V><G><T><D><R><T><G><F><T><F><K><Y><R><D><E><L><K><R><H><Y><N><L><G><E><Y><W><I><E><V><E><M><E><D><L><A><S><F><D><E><D><L><A><D><Y><L><Y><K><Q><P><A><E><H><L><Q><L><L><E><E><A><A><K><E><V><A... | Acts as a component of the MCM2-7 complex. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subu... |
A6NM03 | <M><E><L><R><N><S><T><L><G><S><G><F><I><L><V><G><I><L><N><D><S><G><S><P><E><L><L><Y><A><T><F><T><I><L><Y><M><L><A><L><T><S><N><G><L><L><L><L><A><I><T><I><E><A><R><L><H><M><P><M><Y><L><L><L><G><Q><L><S><L><M><D><L><L><F><T><S><V><V><T><P><K><A><L><A><D><F><L><R><R><E><N><T><I><S><F><G><G><C><A><L><Q><M><F><L><A><L><T><M... | Odorant receptor.<BOP> |
P07451 | <M><A><K><E><W><G><Y><A><S><H><N><G><P><D><H><W><H><E><L><F><P><N><A><K><G><E><N><Q><S><P><V><E><L><H><T><K><D><I><R><H><D><P><S><L><Q><P><W><S><V><S><Y><D><G><G><S><A><K><T><I><L><N><N><G><K><T><C><R><V><V><F><D><D><T><Y><D><R><S><M><L><R><G><G><P><L><P><G><P><Y><R><L><R><Q><F><H><L><H><W><G><S><S><D><D><H><G><S><E><H... | Reversible hydration of carbon dioxide.<BOP> |
Q92637 | <M><W><F><L><T><T><L><L><L><W><V><P><V><D><G><Q><V><D><T><T><K><A><V><I><T><L><Q><P><P><W><V><S><V><F><Q><E><E><T><V><T><L><H><C><E><V><L><H><L><P><G><S><S><S><T><Q><W><F><L><N><G><T><A><T><Q><T><S><T><P><S><Y><R><I><T><S><A><S><V><N><D><S><G><E><Y><R><C><Q><R><G><L><S><G><R><S><D><P><I><Q><L><E><I><H><R><G><W><L><L><L... | May bind to the Fc region of immunoglobulins gamma with a low affinity compared to FCGR1A. May function in the humoral immune response.<BOP> |
O15446 | <M><E><E><P><Q><A><G><D><A><A><R><F><S><C><P><P><N><F><T><A><K><P><P><A><S><E><S><P><R><F><S><L><E><A><L><T><G><P><D><T><E><L><W><L><I><Q><A><P><A><D><F><A><P><E><C><F><N><G><R><H><V><P><L><S><G><S><Q><I><V><K><G><K><L><A><G><K><R><H><R><Y><R><V><L><S><S><C><P><Q><A><G><E><A><T><L><L><A><P><S><T><E><A><G><G><G><L><T><C... | Component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. Involved in UBTF-activated transcription, presumably at a step following PIC formation. Has been described as a component of preformed T-cell recept... |
Q5BKX6 | <M><K><M><A><P><Q><N><A><D><P><E><S><M><Q><V><Q><E><L><S><V><P><L><P><D><P><Q><K><A><G><G><A><E><A><E><N><C><E><T><I><S><E><G><S><I><D><R><I><P><M><R><L><W><V><M><H><G><A><V><M><F><G><R><E><F><C><Y><A><M><E><T><A><L><V><T><P><I><L><L><Q><I><G><L><P><E><Q><Y><Y><S><L><T><W><F><L><S><P><I><L><G><L><I><F><T><P><L><I><G><S... | Proton-associated sucrose transporter. May be able to transport also glucose and fructose.<BOP> |
Q8NH93 | <M><G><M><S><N><L><T><R><L><S><E><F><I><L><L><G><L><S><S><R><S><E><D><Q><R><P><L><F><A><L><F><L><I><I><Y><L><V><T><L><M><G><N><L><L><I><I><L><A><I><H><S><D><P><R><L><Q><N><P><M><Y><F><F><L><S><I><L><S><F><A><D><I><C><Y><T><T><V><I><V><P><K><M><L><V><N><F><L><S><E><K><K><T><I><S><Y><A><E><C><L><A><Q><M><Y><F><F><L><V><F... | Odorant receptor.<BOP> |
Q9BZX2 | <M><A><G><D><S><E><Q><T><L><Q><N><H><Q><Q><P><N><G><G><E><P><F><L><I><G><V><S><G><G><T><A><S><G><K><S><S><V><C><A><K><I><V><Q><L><L><G><Q><N><E><V><D><Y><R><Q><K><Q><V><V><I><L><S><Q><D><S><F><Y><R><V><L><T><S><E><Q><K><A><K><A><L><K><G><Q><F><N><F><D><H><P><D><A><F><D><N><E><L><I><L><K><T><L><K><E><I><T><E><G><K><T><V... | Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-... |
Q96T17 | <M><E><R><G><G><G><G><S><G><T><G><S><R><P><E><G><T><A><R><G><T><S><L><P><G><K><I><A><E><P><G><A><V><R><T><S><Q><P><N><Y><R><P><Q><G><M><E><G><F><L><K><S><D><E><R><Q><R><L><A><K><E><R><R><E><E><R><E><K><C><L><A><A><R><E><Q><Q><I><L><E><K><Q><K><R><A><R><L><Q><Y><E><K><Q><M><E><E><R><W><R><K><L><E><E><Q><R><Q><R><E><D><Q... | Microtubule-stabilizing protein that plays a role in the control of cell motility and neurite outgrowth via direct binding to the microtubule. Acts as a critical cofactor for kinesin transport. In the proximal axon, regulates kinesin-1 family members, KIF5A, KIF5B and KIF5C recruitment to microtubules and contributes t... |
P12724 | <M><V><P><K><L><F><T><S><Q><I><C><L><L><L><L><L><G><L><M><G><V><E><G><S><L><H><A><R><P><P><Q><F><T><R><A><Q><W><F><A><I><Q><H><I><S><L><N><P><P><R><C><T><I><A><M><R><A><I><N><N><Y><R><W><R><C><K><N><Q><N><T><F><L><R><T><T><F><A><N><V><V><N><V><C><G><N><Q><S><I><R><C><P><H><N><R><T><L><N><N><C><H><R><S><R><F><R><V><P><L... | Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration... |
Q8WZ55 | <M><A><D><E><K><T><F><R><I><G><F><I><V><L><G><L><F><L><L><A><L><G><T><F><L><M><S><H><D><R><P><Q><V><Y><G><T><F><Y><A><M><G><S><V><M><V><I><G><G><I><I><W><S><M><C><Q><C><Y><P><K><I><T><F><V><P><A><D><S><D><F><Q><G><I><L><S><P><K><A><M><G><L><L><E><N><G><L><A><A><E><M><K><S><P><S><P><Q><P><P><Y><V><R><L><W><E><E><A><A><Y... | Regulatory subunit of anion-selective CLCNKA:BSND and CLCNKB:BSND heteromeric channels involved in basolateral chloride conductance along the nephron to achieve urine concentration and maintain systemic acid-base homeostasis, and in the stria vascularis of the inner ear to establish the endocochlear potential necessary... |
Q9NP78 | <M><R><L><W><K><A><V><V><V><T><L><A><F><M><S><V><D><I><C><V><T><T><A><I><Y><V><F><S><H><L><D><R><S><L><L><E><D><I><R><H><F><N><I><F><D><S><V><L><D><L><W><A><A><C><L><Y><R><S><C><L><L><L><G><A><T><I><G><V><A><K><N><S><A><L><G><P><R><R><L><R><A><S><W><L><V><I><T><L><V><C><L><F><V><G><I><Y><A><M><V><K><L><L><L><F><S><E><V... | ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen for degradation. Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers. Binds and transports smaller and larger peptides with ... |
O75521 | <M><A><M><A><Y><L><A><W><R><L><A><R><R><S><C><P><S><S><L><Q><V><T><S><F><P><V><V><Q><L><H><M><N><R><T><A><M><R><A><S><Q><K><D><F><E><N><S><M><N><Q><V><K><L><L><K><K><D><P><G><N><E><V><K><L><K><L><Y><A><L><Y><K><Q><A><T><E><G><P><C><N><M><P><K><P><G><V><F><D><L><I><N><K><A><K><W><D><A><W><N><A><L><G><S><L><P><K><E><A><A... | Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Has a preference for 3-trans substrates.<BOP> |
P46098 | <M><L><L><W><V><Q><Q><A><L><L><A><L><L><L><P><T><L><L><A><Q><G><E><A><R><R><S><R><N><T><T><R><P><A><L><L><R><L><S><D><Y><L><L><T><N><Y><R><K><G><V><R><P><V><R><D><W><R><K><P><T><T><V><S><I><D><V><I><V><Y><A><I><L><N><V><D><E><K><N><Q><V><L><T><T><Y><I><W><Y><R><Q><Y><W><T><D><E><F><L><Q><W><N><P><E><D><F><D><N><I><T><K... | Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons.<BOP> |
Q99638 | <M><K><C><L><V><T><G><G><N><V><K><V><L><G><K><A><V><H><S><L><S><R><I><G><D><E><L><Y><L><E><P><L><E><D><G><L><S><L><R><T><V><N><S><S><R><S><A><Y><A><C><F><L><F><A><P><L><F><F><Q><Q><Y><Q><A><A><T><P><G><Q><D><L><L><R><C><K><I><L><M><K><S><F><L><S><V><F><R><S><L><A><M><L><E><K><T><V><E><K><C><C><I><S><L><N><G><R><S><S><R... | Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair. The 9-1-1 comple... |
A0A096LP55 | <M><G><L><E><D><E><Q><K><M><L><T><E><S><G><D><P><E><E><E><E><E><E><E><E><E><L><V><D><P><L><T><T><V><R><E><Q><C><E><Q><L><E><K><C><V><K><A><R><E><R><L><E><L><Y><D><E><H><V><S><S><R><S><H><T><E><E><D><C><T><E><E><L><F><D><F><L><H><A><K><D><H><C><V><A><H><K><L><F><N><N><L><K> | May be a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1.<BOP> |
P50539 | <M><E><R><V><K><M><I><N><V><Q><R><L><L><E><A><A><E><F><L><E><R><R><E><R><E><C><E><H><G><Y><A><S><S><F><P><S><M><P><S><P><R><L><Q><H><S><K><P><P><R><R><L><S><R><A><Q><K><H><S><S><G><S><S><N><T><S><T><A><N><R><S><T><H><N><E><L><E><K><N><R><R><A><H><L><R><L><C><L><E><R><L><K><V><L><I><P><L><G><P><D><C><T><R><H><T><T><L><G... | Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX.<BOP> |
Q7Z418 | <M><E><V><S><G><H><P><Q><A><R><R><C><C><P><E><A><L><G><K><L><F><P><G><L><C><F><L><C><F><L><V><T><Y><A><L><V><G><A><V><V><F><S><A><I><E><D><G><Q><V><L><V><A><A><D><D><G><E><F><E><K><F><L><E><E><L><C><R><I><L><N><C><S><E><T><V><V><E><D><R><K><Q><D><L><Q><G><H><L><Q><K><V><K><P><Q><W><F><N><R><T><T><H><W><S><F><L><S><S><L... | K(+) channel that conducts outward and inward rectifying currents at depolarized and hyperpolarized membrane potentials, respectively. The outward rectifying currents are voltage-dependent, coupled to K(+) electrochemical gradient across the membrane, whereas the inward currents can be induced in response to activation... |
P61236 | <M><V><R><I><S><K><P><K><T><F><Q><A><Y><L><D><D><C><H><R><R><Y><S><C><A><H><C><R><A><H><L><A><N><H><D><D><L><I><S><K><S><F><Q><G><S><Q><G><R><A><Y><L><F><N><S><V><V><N><V><G><C><G><P><A><E><E><R><V><L><L><T><G><L><H><A><V><A><D><I><H><C><E><N><C><K><T><T><L><G><W><K><Y><E><Q><A><F><E><S><S><Q><K><Y><K><E><G><K><Y><I><I... | Involved in proliferation and apoptosis in myeloid precursor cells.<BOP> |
Q86SG2 | <M><D><F><I><S><I><Q><Q><L><V><S><G><E><R><V><E><G><K><V><L><G><F><G><H><G><V><P><D><P><G><A><W><P><S><D><W><R><R><G><P><Q><E><A><V><A><R><E><K><L><K><L><E><E><E><K><K><K><K><L><E><R><F><N><S><T><R><F><N><L><D><N><L><A><D><L><E><N><L><V><Q><R><R><K><K><R><L><R><H><R><V><P><P><R><K><P><E><P><L><V><K><P><Q><S><Q><A><Q><V... | May be involved in the energy metabolism. Could be a molecular link between myofibrillar stretch-induced signaling pathways and muscle gene expression.<BOP> |
A6NMN3 | <M><K><C><Y><F><T><D><H><R><G><E><Q><S><P><T><D><G><T><T><L><S><L><T><S><P><E><S><T><E><E><S><V><E><V><F><W><P><G><T><I><Q><R><E><G><S><S><P><R><P><G><P><A><I><P><R><E><E><G><L><Y><F><A><A><R><D><R><G><M><R><D><W><S><S><S><P><S><S><E><S><S><E><Y><Q><S><Y><S><Q><Y><Q><S><C><C><S><C><M><C><D><E><D><N><A><A><P><Q><S><V><C... | Plays a role in fertilization through the acrosome reaction.<BOP> |
O00221 | <M><N><Q><R><R><S><E><S><R><P><G><N><H><R><L><Q><A><Y><A><E><P><G><K><G><D><S><G><G><A><G><P><L><S><G><S><A><R><R><G><R><G><G><G><G><A><I><R><V><R><R><P><C><W><S><G><G><A><G><R><G><G><G><P><A><W><A><V><R><L><P><T><V><T><A><G><W><T><W><P><A><L><R><T><L><S><S><L><R><A><G><P><S><E><P><H><S><P><G><R><R><P><P><R><A><G><R><P... | Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes.<BOP> |
O43900 | <M><F><A><R><G><S><R><R><R><R><S><G><R><A><P><P><E><A><E><D><P><D><R><G><Q><P><C><N><S><C><R><E><Q><C><P><G><F><L><L><H><G><W><R><K><I><C><Q><H><C><K><C><P><R><E><E><H><A><V><H><A><V><P><V><D><L><E><R><I><M><C><R><L><I><S><D><F><Q><R><H><S><I><S><D><D><D><S><G><C><A><S><E><E><Y><A><W><V><P><P><G><L><K><P><E><Q><V><Y><Q... | Involved in the planar cell polarity. PCP is maintained by two molecular modules, the global and the core modules, PRICKLE3 being part of the core module. Distinct complexes of the core module segregate to opposite sides of the cell, where they interact with the opposite complex in the neighboring cell at or near the a... |
Q9P2W7 | <M><P><K><R><R><D><I><L><A><I><V><L><I><V><L><P><W><T><L><L><I><T><V><W><H><Q><S><T><L><A><P><L><L><A><V><H><K><D><E><G><S><D><P><R><R><E><T><P><P><G><A><D><P><R><E><Y><C><T><S><D><R><D><I><V><E><V><V><R><T><E><Y><V><Y><T><R><P><P><P><W><S><D><T><L><P><T><I><H><V><V><T><P><T><Y><S><R><P><V><Q><K><A><E><L><T><R><M><A><N... | Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effectiv... |
P23280 | <M><R><A><L><V><L><L><L><S><L><F><L><L><G><G><Q><A><Q><H><V><S><D><W><T><Y><S><E><G><A><L><D><E><A><H><W><P><Q><H><Y><P><A><C><G><G><Q><R><Q><S><P><I><N><L><Q><R><T><K><V><R><Y><N><P><S><L><K><G><L><N><M><T><G><Y><E><T><Q><A><G><E><F><P><M><V><N><N><G><H><T><V><Q><I><S><L><P><S><T><M><R><M><T><V><A><D><G><T><V><Y><I><A... | Reversible hydration of carbon dioxide. Its role in saliva is unknown.<BOP> |
Q8NHH9 | <M><A><E><G><D><E><A><A><R><G><Q><Q><P><H><Q><G><L><W><R><R><R><R><T><S><D><P><S><A><A><V><N><H><V><S><S><T><T><S><L><G><E><N><Y><E><D><D><D><L><V><N><S><D><E><V><M><K><K><P><C><P><V><Q><I><V><L><A><H><E><D><D><H><N><F><E><L><D><E><E><A><L><E><Q><I><L><L><Q><E><H><I><R><D><L><N><I><V><V><V><S><V><A><G><A><F><R><K><G><K... | GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis.<BOP> |
Q6ZWL3 | <M><A><G><L><W><L><G><L><V><W><Q><K><L><L><L><W><G><A><A><S><A><L><S><L><A><G><A><S><L><V><L><S><L><L><Q><R><V><A><S><Y><A><R><K><W><Q><Q><M><R><P><I><P><T><V><A><R><A><Y><P><L><V><G><H><A><L><L><M><K><P><D><G><R><E><F><F><Q><Q><I><I><E><Y><T><E><E><Y><R><H><M><P><L><L><K><L><W><V><G><P><V><P><M><V><A><L><Y><N><A><E><N... | A cytochrome P450 monooxygenase involved in fatty acid metabolism in the eye. Catalyzes the omega-hydroxylation of polyunsaturated fatty acids. Omega hydroxylates saturated fatty acids such as laurate, myristate and palmitate, the catalytic efficiency decreasing in the following order: myristate > laurate > palmitate. ... |
A0A0A6YYK7 | <M><L><T><A><S><L><L><R><A><V><I><A><S><I><C><V><V><S><S><M><A><Q><K><V><T><Q><A><Q><T><E><I><S><V><V><E><K><E><D><V><T><L><D><C><V><Y><E><T><R><D><T><T><Y><Y><L><F><W><Y><K><Q><P><P><S><G><E><L><V><F><L><I><R><R><N><S><F><D><E><Q><N><E><I><S><G><R><Y><S><W><N><F><Q><K><S><T><S><S><F><N><F><T><I><T><A><S><Q><V><V><D><S... | V region of the variable domain of T cell receptor. Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility. Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering ... |
Q8N4U5 | <M><P><F><N><G><E><K><Q><C><V><G><E><D><Q><P><S><D><S><D><S><S><R><F><S><E><S><M><A><S><L><S><D><Y><E><C><S><R><Q><S><F><A><S><D><S><S><S><K><S><S><S><P><A><S><T><S><P><P><R><V><V><T><F><D><E><V><M><A><T><A><R><N><L><S><N><L><T><L><A><H><E><I><A><V><N><E><N><F><Q><L><K><Q><E><A><L><P><E><K><S><L><A><G><R><V><K><H><I><V... | Promotes the migration of muscle-derived satellite cells (MDSCs) during differentiation throught interaction with FMNL2 and therefore may participate in microfilament assembly.<BOP> |
Q9NPE2 | <M><A><V><T><L><S><L><L><L><G><G><R><V><C><A><A><V><T><R><C><G><F><A><T><R><G><V><A><G><P><G><P><I><G><R><E><P><D><P><D><S><D><W><E><P><E><E><R><E><L><Q><E><V><E><S><T><L><K><R><Q><K><Q><A><I><R><F><Q><K><I><R><R><Q><M><E><A><P><G><A><P><P><R><T><L><T><W><E><A><M><E><Q><I><R><Y><L><H><E><E><F><P><E><S><W><S><V><P><R><L... | Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunit... |
Q6L8G4 | <M><G><C><C><G><C><S><G><G><C><G><S><G><C><G><G><C><G><S><G><S><G><G><C><G><S><G><C><G><G><C><G><S><S><C><C><V><P><I><C><C><C><K><P><V><C><C><C><V><P><A><C><S><C><S><S><C><G><S><C><G><G><S><K><G><G><C><G><S><C><G><S><S><K><G><G><C><G><S><C><G><C><S><Q><S><N><C><C><K><P><C><C><S><S><S><G><C><G><S><F><C><C><Q><S><S><C><S... | In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hai... |
Q01658 | <M><A><S><S><S><G><N><D><D><D><L><T><I><P><R><A><A><I><N><K><M><I><K><E><T><L><P><N><V><R><V><A><N><D><A><R><E><L><V><V><N><C><C><T><E><F><I><H><L><I><S><S><E><A><N><E><I><C><N><K><S><E><K><K><T><I><S><P><E><H><V><I><Q><A><L><E><S><L><G><F><G><S><Y><I><S><E><V><K><E><V><L><Q><E><C><K><T><V><A><L><K><R><R><K><A><S><S><R... | The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Co... |
Q8IUI8 | <M><R><G><A><M><E><L><E><P><E><L><L><L><Q><E><A><R><E><N><V><E><A><A><Q><S><Y><R><R><E><L><G><H><R><L><E><G><L><R><E><A><R><R><Q><I><K><E><S><A><S><Q><T><R><D><V><L><K><Q><H><F><N><D><L><K><G><T><L><G><K><L><L><D><E><R><L><V><T><L><L><Q><E><V><D><T><I><E><Q><E><T><I><K><P><L><D><D><C><Q><K><L><I><E><H><G><V><N><T><A><E... | May play a role in the negative regulation of cell cycle progression.<BOP> |
Q7Z4Y8 | <M><A><P><F><V><R><N><L><V><E><K><T><P><A><L><V><N><A><A><V><T><Y><L><K><P><R><L><A><A><F><W><Y><Y><T><T><V><E><L><V><P><P><T><P><A><E><I><P><R><A><I><Q><S><L><K><K><I><V><S><S><A><Q><T><G><S><F><K><Q><L><T><V><K><E><A><L><L><N><G><L><V><A><T><E><V><S><T><W><F><Y><V><R><E><I><T><G><K><R><G><I><I><G> | Mitochondrial membrane ATP synthase.<BOP> |
O95800 | <M><N><S><T><G><H><L><Q><D><A><P><N><A><T><S><L><H><V><P><H><S><Q><E><G><N><S><T><S><L><Q><E><G><L><Q><D><L><I><H><T><A><T><L><V><T><C><T><F><L><L><A><V><I><F><C><L><G><S><Y><G><N><F><I><V><F><L><S><F><F><D><P><A><F><R><K><F><R><T><N><F><D><F><M><I><L><N><L><S><F><C><D><L><F><I><C><G><V><T><A><P><M><F><T><F><V><L><F><F... | G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling ... |
Q92633 | <M><A><A><I><S><T><S><I><P><V><I><S><Q><P><Q><F><T><A><M><N><E><P><Q><C><F><Y><N><E><S><I><A><F><F><Y><N><R><S><G><K><H><L><A><T><E><W><N><T><V><S><K><L><V><M><G><L><G><I><T><V><C><I><F><I><M><L><A><N><L><L><V><M><V><A><I><Y><V><N><R><R><F><H><F><P><I><Y><Y><L><M><A><N><L><A><A><A><D><F><F><A><G><L><A><Y><F><Y><L><M><F... | Receptor for lysophosphatidic acid. Contributes to the regulation of cell shape. Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction. Through its function as LPA receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding. Inhi... |
D6R9N7 | <M><E><D><D><S><L><Y><L><G><G><E><W><Q><F><N><H><F><S><K><L><T><S><S><R><P><D><A><A><F><A><E><I><Q><R><T><S><L><P><E><K><S><P><L><S><C><E><T><R><V><D><L><C><D><D><L><A><P><V><A><R><Q><L><A><P><R><E><K><L><P><L><S><S><R><R><P><A><A><V><G><A><G><L><Q><N><M><G><N><T><C><Y><V><N><A><S><L><Q><C><L><T><Y><T><P><P><L><A><N><Y... | Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.<BOP> |
O43402 | <M><P><G><V><K><L><T><T><Q><A><Y><C><K><M><V><L><H><G><A><K><Y><P><H><C><A><V><N><G><L><L><V><A><E><K><Q><K><P><R><K><E><H><L><P><L><G><G><P><G><A><H><H><T><L><F><V><D><C><I><P><L><F><H><G><T><L><A><L><A><P><M><L><E><V><A><L><T><L><I><D><S><W><C><K><D><H><S><Y><V><I><A><G><Y><Y><Q><A><N><E><R><V><K><D><A><S><P><N><Q><V... | Part of the endoplasmic reticulum membrane protein complex. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfe... |
P15173 | <M><E><L><Y><E><T><S><P><Y><F><Y><Q><E><P><R><F><Y><D><G><E><N><Y><L><P><V><H><L><Q><G><F><E><P><P><G><Y><E><R><T><E><L><T><L><S><P><E><A><P><G><P><L><E><D><K><G><L><G><T><P><E><H><C><P><G><Q><C><L><P><W><A><C><K><V><C><K><R><K><S><V><S><V><D><R><R><R><A><A><T><L><R><E><K><R><R><L><K><K><V><N><E><A><F><E><A><L><K><R><S... | Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscl... |
P02765 | <M><K><S><L><V><L><L><L><C><L><A><Q><L><W><G><C><H><S><A><P><H><G><P><G><L><I><Y><R><Q><P><N><C><D><D><P><E><T><E><E><A><A><L><V><A><I><D><Y><I><N><Q><N><L><P><W><G><Y><K><H><T><L><N><Q><I><D><E><V><K><V><W><P><Q><Q><P><S><G><E><L><F><E><I><E><I><D><T><L><E><T><T><C><H><V><L><D><P><T><P><V><A><R><C><S><V><R><Q><L><K><E... | Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions.<BOP> |
Q12837 | <M><M><M><M><S><L><N><S><K><Q><A><F><S><M><P><H><G><G><S><L><H><V><E><P><K><Y><S><A><L><H><S><T><S><P><G><S><S><A><P><I><A><P><S><A><S><S><P><S><S><S><S><N><A><G><G><G><G><G><G><G><G><G><G><G><G><G><G><G><R><S><S><S><S><S><S><S><G><S><S><G><G><G><G><S><E><A><M><R><R><A><C><L><P><T><P><P><S><N><I><F><G><G><L><D><E><S><L... | Tissue-specific DNA-binding transcription factor involved in the development and differentiation of target cells.<BOP> |
P22234 | <M><A><T><A><E><V><L><N><I><G><K><K><L><Y><E><G><K><T><K><E><V><Y><E><L><L><D><S><P><G><K><V><L><L><Q><S><K><D><Q><I><T><A><G><N><A><A><R><K><N><H><L><E><G><K><A><A><I><S><N><K><I><T><S><C><I><F><Q><L><L><Q><E><A><G><I><K><T><A><F><T><R><K><C><G><E><T><A><F><I><A><P><Q><C><E><M><I><P><I><E><W><V><C><R><R><I><A><T><G><S... | Bifunctional phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazole succinocarboxamide synthetase catalyzing two reactions of the de novo purine biosynthetic pathway.<BOP> |
P24385 | <M><E><H><Q><L><L><C><C><E><V><E><T><I><R><R><A><Y><P><D><A><N><L><L><N><D><R><V><L><R><A><M><L><K><A><E><E><T><C><A><P><S><V><S><Y><F><K><C><V><Q><K><E><V><L><P><S><M><R><K><I><V><A><T><W><M><L><E><V><C><E><E><Q><K><C><E><E><E><V><F><P><L><A><M><N><Y><L><D><R><F><L><S><L><E><P><V><K><K><S><R><L><Q><L><L><G><A><T><C><M... | Regulatory component of the cyclin D1-CDK4. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 ... |
O75506 | <M><A><E><T><D><P><K><T><V><Q><D><L><T><S><V><V><Q><T><L><L><Q><Q><M><Q><D><K><F><Q><T><M><S><D><Q><I><I><G><R><I><D><D><M><S><S><R><I><D><D><L><E><K><N><I><A><D><L><M><T><Q><A><G><V><E><E><L><E><S><E><N><K><I><P><A><T><Q><K><S> | Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process.<BOP> |
Q7Z7C8 | <M><A><D><A><A><A><T><A><G><A><G><G><S><G><T><R><S><G><S><K><Q><S><T><N><P><A><D><N><Y><H><L><A><R><R><R><T><L><Q><V><V><V><S><S><L><L><T><E><A><G><F><E><S><A><E><K><A><S><V><E><T><L><T><E><M><L><Q><S><Y><I><S><E><I><G><R><S><A><K><S><Y><C><E><H><T><A><R><T><Q><P><T><L><S><D><I><V><V><T><L><V><E><M><G><F><N><V><D><T><L... | The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II.<BOP> |
Q14642 | <M><A><G><K><A><A><A><P><G><T><A><V><L><L><V><T><A><N><V><G><S><L><F><D><D><P><E><N><L><Q><K><N><W><L><R><E><F><Y><Q><V><V><H><T><H><K><P><H><F><M><A><L><H><C><Q><E><F><G><G><K><N><Y><E><A><S><M><S><H><V><D><K><F><V><K><E><L><L><S><S><D><A><M><K><E><Y><N><R><A><R><V><Y><L><D><E><N><Y><K><S><Q><E><H><F><T><A><L><G><S><F... | Phosphatase that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate, and inositol 1,3,4,5-tetrasphosphate to inositol 1,3,4-trisphosphate.<BOP> |
P50583 | <M><A><L><R><A><C><G><L><I><I><F><R><R><C><L><I><P><K><V><D><N><N><A><I><E><F><L><L><L><Q><A><S><D><G><I><H><H><W><T><P><P><K><G><H><V><E><P><G><E><D><D><L><E><T><A><L><R><E><T><Q><E><E><A><G><I><E><A><G><Q><L><T><I><I><E><G><F><K><R><E><L><N><Y><V><A><R><N><K><P><K><T><V><I><Y><W><L><A><E><V><K><D><Y><D><V><E><I><R><L... | Catalyzes the asymmetric hydrolysis of diadenosine 5',5'''-P1,P4-tetraphosphate. Exhibits decapping activity towards FAD-capped RNAs and dpCoA-capped RNAs in vitro.<BOP> |
Q7Z4K8 | <M><A><E><G><E><D><M><Q><T><F><T><S><I><M><D><A><L><V><R><I><S><T><S><M><K><N><M><E><K><E><L><L><C><P><V><C><Q><E><M><Y><K><Q><P><L><V><L><P><C><T><H><N><V><C><Q><A><C><A><R><E><V><L><G><Q><Q><G><Y><I><G><H><G><G><D><P><S><S><E><P><T><S><P><A><S><T><P><S><T><R><S><P><R><L><S><R><R><T><L><P><K><P><D><R><L><D><R><L><L><K... | Microtubule-associated protein that is involved in the formation of parallel microtubule bundles linked by cross-bridges in the proximal axon. Required for the uniform orientation and maintenance of the parallel microtubule fascicles, which are important for efficient cargo delivery and trafficking in axons. Thereby al... |
Q9Y448 | <M><A><A><P><E><A><P><P><L><D><R><V><F><R><T><T><W><L><S><T><E><C><D><S><H><P><L><P><P><S><Y><R><K><F><L><F><E><T><Q><A><A><D><L><A><G><G><T><T><V><A><A><G><N><L><L><N><E><S><E><K><D><C><G><Q><D><R><R><A><P><G><V><Q><P><C><R><L><V><T><M><T><S><V><V><K><T><V><Y><S><L><Q><P><P><S><A><L><S><G><G><Q><P><A><D><T><Q><T><R><A... | Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase. Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. The astrin. Required... |
P01920 | <M><S><W><K><K><A><L><R><I><P><G><G><L><R><A><A><T><V><T><L><M><L><A><M><L><S><T><P><V><A><E><G><R><D><S><P><E><D><F><V><Y><Q><F><K><A><M><C><Y><F><T><N><G><T><E><R><V><R><Y><V><T><R><Y><I><Y><N><R><E><E><Y><A><R><F><D><S><D><V><E><V><Y><R><A><V><T><P><L><G><P><P><D><A><E><Y><W><N><S><Q><K><E><V><L><E><R><T><R><A><E><L... | Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by deg... |
Q96FX8 | <M><I><R><C><G><L><A><C><E><R><C><R><W><I><L><P><L><L><L><L><S><A><I><A><F><D><I><I><A><L><A><G><R><G><W><L><Q><S><S><D><H><G><Q><T><S><S><L><W><W><K><C><S><Q><E><G><G><G><S><G><S><Y><E><E><G><C><Q><S><L><M><E><Y><A><W><G><R><A><A><A><A><M><L><F><C><G><F><I><I><L><V><I><C><F><I><L><S><F><F><A><L><C><G><P><Q><M><L><V><F... | Component of intercellular desmosome junctions. Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. Thereby plays a role in barrier function of the skin against infection. Plays a role in mammary epithelial tissue homeostasis and remodeling during and after pregnancy,... |
Q9NZJ0 | <M><L><F><N><S><V><L><R><Q><P><Q><L><G><V><L><R><N><G><W><S><S><Q><Y><P><L><Q><S><L><L><T><G><Y><Q><C><S><G><N><D><E><H><T><S><Y><G><E><T><G><V><P><V><P><P><F><G><C><T><F><S><S><A><P><N><M><E><H><V><L><A><V><A><N><E><E><G><F><V><R><L><Y><N><T><E><S><Q><S><F><R><K><K><C><F><K><E><W><M><A><H><W><N><A><V><F><D><L><A><W><V... | Substrate-specific adapter of a DCX. CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. KMT5A degradation is also important for a proper ... |
Q9NWN3 | <M><H><L><K><P><Y><W><K><L><Q><K><K><E><H><P><P><E><V><S><R><E><T><Q><R><T><P><M><N><H><Q><K><A><V><N><D><E><T><C><K><A><S><H><I><T><S><S><V><F><P><S><A><S><L><G><K><A><S><S><R><K><P><F><G><I><L><S><P><N><V><L><C><S><M><S><G><K><S><P><V><E><S><S><L><N><V><K><T><K><K><N><A><P><S><A><T><I><H><Q><G><E><E><E><G><P><L><D><I... | Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.<BOP> |
P21673 | <M><A><K><F><V><I><R><P><A><T><A><A><D><C><S><D><I><L><R><L><I><K><E><L><A><K><Y><E><Y><M><E><E><Q><V><I><L><T><E><K><D><L><L><E><D><G><F><G><E><H><P><F><Y><H><C><L><V><A><E><V><P><K><E><H><W><T><P><E><G><H><S><I><V><G><F><A><M><Y><Y><F><T><Y><D><P><W><I><G><K><L><L><Y><L><E><D><F><F><V><M><S><D><Y><R><G><F><G><I><G><S... | Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine = spermidine >> spermine > N(1)-acetylspermine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells. Also ac... |
Q96P09 | <M><T><G><Y><E><A><R><L><I><T><F><G><T><W><M><Y><S><V><N><K><E><Q><L><A><R><A><G><F><Y><A><I><G><Q><E><D><K><V><Q><C><F><H><C><G><G><G><L><A><N><W><K><P><K><E><D><P><W><E><Q><H><A><K><W><Y><P><G><C><K><Y><L><L><E><E><K><G><H><E><Y><I><N><N><I><H><L><T><R><S><L><E><G><A><L><V><Q><T><T><K><K><T><P><S><L><T><K><R><I><S><D... | Protects against apoptosis mediated by BAX.<BOP> |
Q969G5 | <M><R><E><S><A><L><E><R><G><P><V><P><E><A><P><A><G><G><P><V><H><A><V><T><V><V><T><L><L><E><K><L><A><S><M><L><E><T><L><R><E><R><Q><G><G><L><A><R><R><Q><G><G><L><A><G><S><V><R><R><I><Q><S><G><L><G><A><L><S><R><S><H><D><T><T><S><N><T><L><A><Q><L><L><A><K><A><E><R><V><S><S><H><A><N><A><A><Q><E><R><A><V><R><R><A><A><Q><V><Q... | Regulates the traffic and/or budding of caveolae.<BOP> |
Q92915 | <M><A><A><A><I><A><S><G><L><I><R><Q><K><R><Q><A><R><E><Q><H><W><D><R><P><S><A><S><R><R><R><S><S><P><S><K><N><R><G><L><C><N><G><N><L><V><D><I><F><S><K><V><R><I><F><G><L><K><K><R><R><L><R><R><Q><D><P><Q><L><K><G><I><V><T><R><L><Y><C><R><Q><G><Y><Y><L><Q><M><H><P><D><G><A><L><D><G><T><K><D><D><S><T><N><S><T><L><F><N><L><I... | Probably involved in nervous system development and function.<BOP> |
P56381 | <M><V><A><Y><W><R><Q><A><G><L><S><Y><I><R><Y><S><Q><I><C><A><K><A><V><R><D><A><L><K><T><E><F><K><A><N><A><E><K><T><S><G><S><N><V><K><I><V><K><V><K><K><E> | Subunit epsilon, of the mitochondrial membrane ATP synthase complex. May be essential for the assembly of F(1) and may play an important role in the incorporation of the hydrophobic subunit c into the F(1)-c oligomer rotor of the mitochondrial ATP synthase complex.<BOP> |
Q11201 | <M><V><T><L><R><K><R><T><L><K><V><L><T><F><L><V><L><F><I><F><L><T><S><F><F><L><N><Y><S><H><T><M><V><A><T><T><W><F><P><K><Q><M><V><L><E><L><S><E><N><L><K><R><L><I><K><H><R><P><C><T><C><T><H><C><I><G><Q><R><K><L><S><A><W><F><D><E><R><F><N><Q><T><M><Q><P><L><L><T><A><Q><N><A><L><L><E><D><D><T><Y><R><W><W><L><R><L><Q><R><E... | A beta-galactoside alpha2->3 sialyltransferase involved in terminal sialylation of glycoproteins and glycolipids. Transfers sialic acid to asialofetuin, presumably onto Galbeta-(1->3)-GalNAc-O-Ser. Sialylates GM1a, GA1 and GD1b gangliosides to form GD1a, GM1b and GT1b, respectively.<BOP> |
Q8WVH0 | <M><A><F><M><V><K><T><M><V><G><G><Q><L><K><N><L><T><G><S><L><G><G><G><E><D><K><G><D><G><D><K><S><A><A><E><A><Q><G><M><S><R><E><E><Y><E><E><Y><Q><K><Q><L><V><E><E><K><M><E><R><D><A><Q><F><T><Q><R><K><A><E><R><A><T><L><R><S><H><F><R><D><K><Y><R><L><P><K><N><E><T><D><E><S><Q><I><Q><M><A><G><G><D><V><E><L><P><R><E><L><A><K... | Complexin that regulates SNARE protein complex-mediated synaptic vesicle fusion. Required for the maintenance of synaptic ultrastructure in the adult retina. Positively regulates synaptic transmission through synaptic vesicle availability and exocytosis of neurotransmitters at photoreceptor ribbon synapses in the retin... |
Q06055 | <M><F><A><C><S><K><F><V><S><T><P><S><L><V><K><S><T><S><Q><L><L><S><R><P><L><S><A><V><V><L><K><R><P><E><I><L><T><D><E><S><L><S><S><L><A><V><S><C><P><L><T><S><L><V><S><S><R><S><F><Q><T><S><A><I><S><R><D><I><D><T><A><A><K><F><I><G><A><G><A><A><T><V><G><V><A><G><S><G><A><G><I><G><T><V><F><G><S><L><I><I><G><Y><A><R><N><P><S... | Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous ca... |
P55735 | <M><V><S><V><I><N><T><V><D><T><S><H><E><D><M><I><H><D><A><Q><M><D><Y><Y><G><T><R><L><A><T><C><S><S><D><R><S><V><K><I><F><D><V><R><N><G><G><Q><I><L><I><A><D><L><R><G><H><E><G><P><V><W><Q><V><A><W><A><H><P><M><Y><G><N><I><L><A><S><C><S><Y><D><R><K><V><I><I><W><R><E><E><N><G><T><W><E><K><S><H><E><H><A><G><H><D><S><S><V><N... | Functions as a component of the nuclear pore complex. As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway. The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex. GATOR2 probably acts as an E3 ubiquitin-... |
Q5VV42 | <M><P><S><A><S><C><D><T><L><L><D><D><I><E><D><I><V><S><Q><E><D><S><K><P><Q><D><R><H><F><V><R><K><D><V><V><P><K><V><R><R><R><N><T><Q><K><Y><L><Q><E><E><E><N><S><P><P><S><D><S><T><I><P><G><I><Q><K><I><W><I><R><T><W><G><C><S><H><N><N><S><D><G><E><Y><M><A><G><Q><L><A><A><Y><G><Y><K><I><T><E><N><A><S><D><A><D><L><W><L><L><N... | Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.<BOP> |
Q16881 | <M><G><C><A><E><G><K><A><V><A><A><A><A><P><T><E><L><Q><T><K><G><K><N><G><D><G><R><R><R><S><A><K><D><H><H><P><G><K><T><L><P><E><N><P><A><G><F><T><S><T><A><T><A><D><S><R><A><L><L><Q><A><Y><I><D><G><H><S><V><V><I><F><S><R><S><T><C><T><R><C><T><E><V><K><K><L><F><K><S><L><C><V><P><Y><F><V><L><E><L><D><Q><T><E><D><G><R><A><L... | Reduces disulfideprotein thioredoxin. Homodimeric flavoprotein involved in the regulation of cellular redox reactions, growth and differentiation. Contains a selenocysteine residue at the C-terminal active site that is essential for catalysis. Induces actin and tubulin polymerization, leading to formation of cell membr... |
P20674 | <M><L><G><A><A><L><R><R><C><A><V><A><A><T><T><R><A><D><P><R><G><L><L><H><S><A><R><T><P><G><P><A><V><A><I><Q><S><V><R><C><Y><S><H><G><S><Q><E><T><D><E><E><F><D><A><R><W><V><T><Y><F><N><K><P><D><I><D><A><W><E><L><R><K><G><I><N><T><L><V><T><Y><D><M><V><P><E><P><K><I><I><D><A><A><L><R><A><C><R><R><L><N><D><F><A><S><T><V><R... | Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CII... |
P49914 | <M><A><A><A><A><V><S><S><A><K><R><S><L><R><G><E><L><K><Q><R><L><R><A><M><S><A><E><E><R><L><R><Q><S><R><V><L><S><Q><K><V><I><A><H><S><E><Y><Q><K><S><K><R><I><S><I><F><L><S><M><Q><D><E><I><E><T><E><E><I><I><K><D><I><F><Q><R><G><K><I><C><F><I><P><R><Y><R><F><Q><S><N><H><M><D><M><V><R><I><E><S><P><E><E><I><S><L><L><P><K><T... | Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10-methenyltetrahydrofol... |
Q8NGS1 | <M><K><R><E><N><Q><S><S><V><S><E><F><L><L><L><D><L><P><I><W><P><E><Q><Q><A><V><F><F><T><L><F><L><G><M><Y><L><I><T><V><L><G><N><L><L><I><I><L><L><I><R><L><D><S><H><L><H><T><P><M><F><F><F><L><S><H><L><A><L><T><D><I><S><L><S><S><V><T><V><P><K><M><L><L><S><M><Q><T><Q><D><Q><S><I><L><Y><A><G><C><V><T><Q><M><Y><F><F><I><F><F... | Odorant receptor.<BOP> |
P80404 | <M><A><S><M><L><L><A><Q><R><L><A><C><S><F><Q><H><S><Y><R><L><L><V><P><G><S><R><H><I><S><Q><A><A><A><K><V><D><V><E><F><D><Y><D><G><P><L><M><K><T><E><V><P><G><P><R><S><Q><E><L><M><K><Q><L><N><I><I><Q><N><A><E><A><V><H><F><F><C><N><Y><E><E><S><R><G><N><Y><L><V><D><V><D><G><N><R><M><L><D><L><Y><S><Q><I><S><S><V><P><I><G><Y... | Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively.<BOP> |
P16619 | <M><Q><V><S><T><A><A><L><A><V><L><L><C><T><M><A><L><C><N><Q><V><L><S><A><P><L><A><A><D><T><P><T><A><C><C><F><S><Y><T><S><R><Q><I><P><Q><N><F><I><A><D><Y><F><E><T><S><S><Q><C><S><K><P><S><V><I><F><L><T><K><R><G><R><Q><V><C><A><D><P><S><E><E><W><V><Q><K><Y><V><S><D><L><E><L><S><A> | Chemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an inhibitor of HIV-1-infection. The processed form LD78-beta(3-70) shows a 20-fold to 30-fold higher chemotactic activity and is a very potent inhibitor of HIV-1-infection. LD78-beta(3-70) is also a ligand for CCR1, CCR3 and CCR5.<BOP> |
P23769 | <M><E><V><A><P><E><Q><P><R><W><M><A><H><P><A><V><L><N><A><Q><H><P><D><S><H><H><P><G><L><A><H><N><Y><M><E><P><A><Q><L><L><P><P><D><E><V><D><V><F><F><N><H><L><D><S><Q><G><N><P><Y><Y><A><N><P><A><H><A><R><A><R><V><S><Y><S><P><A><H><A><R><L><T><G><G><Q><M><C><R><P><H><L><L><H><S><P><G><L><P><W><L><D><G><G><K><A><A><L><S><A... | Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'.<BOP> |
Q8WXA9 | <M><T><S><L><M><P><G><A><G><L><L><P><I><P><T><P><N><P><L><T><T><L><G><V><S><L><S><S><L><G><A><I><P><A><A><A><L><D><P><N><I><A><T><L><G><E><I><P><Q><P><P><L><M><G><N><V><D><P><S><K><I><D><E><I><R><R><T><V><Y><V><G><N><L><N><S><Q><T><T><T><A><D><Q><L><L><E><F><F><K><Q><V><G><E><V><K><F><V><R><M><A><G><D><E><T><Q><P><T><R... | Participates in the regulation of alternative splicing by modulating the activity of other splice facors. Inhibits the splicing activity of SFRS1, SFRS2 and SFRS6. Augments the splicing activity of SFRS3.<BOP> |
Q5M7Z0 | <M><P><L><F><L><L><S><L><P><T><P><P><S><A><S><G><H><E><R><R><Q><R><P><E><A><K><T><S><G><S><E><K><K><Y><L><R><A><M><Q><A><N><R><S><Q><L><H><S><P><P><G><T><G><S><S><E><D><A><S><T><P><Q><C><V><H><T><R><L><T><G><E><G><S><C><P><H><S><G><D><V><H><I><Q><I><N><S><I><P><K><E><C><A><E><N><A><S><S><R><N><I><R><S><G><V><H><S><C><A... | E3 ubiquitin-protein ligase that acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis.<BOP> |
Q96P56 | <M><A><A><Y><Q><Q><E><E><Q><M><Q><L><P><R><A><D><A><I><R><S><R><L><I><D><T><F><S><L><I><E><H><L><Q><G><L><S><Q><A><V><P><R><H><T><I><R><E><L><L><D><P><S><R><Q><K><K><L><V><L><G><D><Q><H><Q><L><V><R><F><S><I><K><P><Q><R><I><E><Q><I><S><H><A><Q><R><L><L><S><R><L><H><V><R><C><S><Q><R><P><P><L><S><L><W><A><G><W><V><L><E><C... | Pore-forming subunit of the CatSper complex, a sperm-specific voltage-gated calcium channel, that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte.<BOP> |
P61803 | <M><S><A><S><V><V><S><V><I><S><R><F><L><E><E><Y><L><S><S><T><P><Q><R><L><K><L><L><D><A><Y><L><L><Y><I><L><L><T><G><A><L><Q><F><G><Y><C><L><L><V><G><T><F><P><F><N><S><F><L><S><G><F><I><S><C><V><G><S><F><I><L><A><V><C><L><R><I><Q><I><N><P><Q><N><K><A><D><F><Q><G><I><S><P><E><R><A><F><A><D><F><L><F><A><S><T><I><L><H><L><V... | Subunit of the oligosaccharyl transferase. Required for the assembly of both SST3A- and SS3B-containing OST complexes. Loss of the DAD1 protein triggers apoptosis.<BOP> |
Q6PB30 | <M><S><A><T><T><A><C><W><P><A><F><T><V><L><G><E><A><R><G><D><Q><V><D><W><S><R><L><Y><R><D><T><G><L><V><K><M><S><R><K><P><R><A><S><S><P><F><S><N><N><H><P><S><T><P><K><R><F><P><R><Q><P><R><R><E><K><G><P><V><K><E><V><P><G><T><K><G><S><P> | May play an important role in maintaining centrosome integrity during mitosis.<BOP> |
Q96G04 | <M><A><P><E><E><N><A><G><T><E><L><L><L><Q><S><F><E><R><R><F><L><A><A><R><T><L><R><S><F><P><W><Q><S><L><E><A><K><L><R><D><S><S><D><S><E><L><L><R><D><I><L><H><K><T><V><K><H><P><V><C><V><K><H><P><P><S><V><K><Y><A><R><C><F><L><S><E><L><I><K><K><H><E><A><V><H><T><E><P><L><D><E><L><Y><E><A><L><A><E><T><L><M><A><K><E><S><T><Q... | Catalyzes the trimethylation of eukaryotic elongation factor 2 (EEF2) on 'Lys-525'.<BOP> |
Q8N3Y7 | <M><S><F><N><L><Q><S><S><K><K><L><F><I><F><L><G><K><S><L><F><S><L><L><E><A><M><I><F><A><L><L><P><K><P><R><K><N><V><A><G><E><I><V><L><I><T><G><A><G><S><G><L><G><R><L><L><A><L><Q><F><A><R><L><G><S><V><L><V><L><W><D><I><N><K><E><G><N><E><E><T><C><K><M><A><R><E><A><G><A><T><R><V><H><A><Y><T><C><D><C><S><Q><K><E><G><V><Y><R... | Oxidoreductase with strong preference for NAD. Active in both the oxidative and reductive directions. Oxidizes all-trans-retinol in all-trans-retinaldehyde. No activity was detected with 11-cis-retinol or 11-cis-retinaldehyde as substrates with either NAD(+)/NADH or NADP(+)/NADPH.<BOP> |
P0DPQ6 | <M><L><K><M><S><G><W><Q><R><Q><S><Q><N><Q><S><W><N><L><R><R><E><C><S><R><R><K><C><I><F><I><H><H><H><T> | Product of the upstream open reading frame (uORF) of DDIT3/CHOP that is specifically produced in absence of stress, thereby preventing translation of downstream stress effector DDIT3/CHOP.<BOP> |
P63092 | <M><G><C><L><G><N><S><K><T><E><D><Q><R><N><E><E><K><A><Q><R><E><A><N><K><K><I><E><K><Q><L><Q><K><D><K><Q><V><Y><R><A><T><H><R><L><L><L><L><G><A><G><E><S><G><K><S><T><I><V><K><Q><M><R><I><L><H><V><N><G><F><N><G><E><G><G><E><E><D><P><Q><A><A><R><S><N><S><D><G><E><K><A><T><K><V><Q><D><I><K><N><N><L><K><E><A><I><E><T><I><V... | Guanine nucleotide-binding proteins. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP t... |
P0DTA3 | <M><G><Q><I><L><G><K><I><M><M><S><H><Q><P><Q><P><Q><E><E><R><S><P><Q><R><S><T><S><G><Y><P><L><Q><E><V><V><D><D><E><V><S><G><P><S><A><P><G><V><D><P><S><P><P><R><R><S><L><G><W><K><R><K><R><E><C><L><D><E><S><D><D><E><P><E><K><E><L><A><P><E><P><E><E><T><W><V><A><E><T><L><C><G><L><K><M><K><A><K><R><R><R><V><S><L><V><L><P><E... | Acts as a modulator of the nicotinic acetylcholine receptor alpha-7 (CHRNA7) activity.<BOP> |
Q6ECI4 | <M><K><S><Q><E><E><V><E><V><A><G><I><K><L><C><K><A><M><S><L><G><S><V><T><F><T><D><V><A><I><D><F><S><Q><D><E><W><E><W><L><N><L><A><Q><R><S><L><Y><K><K><V><M><L><E><N><Y><R><N><L><V><S><V><G><L><C><I><S><K><P><D><V><I><S><L><L><E><Q><E><K><D><P><W><V><I><K><G><G><M><N><R><G><L><C><P><D><L><E><C><V><W><V><T><K><S><L><S><L... | May be involved in transcriptional regulation.<BOP> |
P09012 | <M><A><V><P><E><T><R><P><N><H><T><I><Y><I><N><N><L><N><E><K><I><K><K><D><E><L><K><K><S><L><Y><A><I><F><S><Q><F><G><Q><I><L><D><I><L><V><S><R><S><L><K><M><R><G><Q><A><F><V><I><F><K><E><V><S><S><A><T><N><A><L><R><S><M><Q><G><F><P><F><Y><D><K><P><M><R><I><Q><Y><A><K><T><D><S><D><I><I><A><K><M><K><G><T><F><V><E><R><D><R><K... | Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds ste... |
Q8NDD1 | <M><R><V><D><S><S><A><D><P><T><M><S><Q><E><Q><G><P><G><S><S><T><P><P><S><S><P><T><L><L><D><A><L><L><Q><N><L><Y><D><F><G><G><T><E><G><E><T><E><Q><K><K><I><I><K><K><R><E><N><K><K><R><D><V><M><A><S><A><A><L><A><A><E><P><S><P><L><P><G><S><L><I><R><G><Q><R><K><S><A><S><S><F><F><K><E><L><R><E><E><R><H><C><A><P><S><G><T><P><T... | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, mo... |
Q6P3W2 | <M><M><A><V><E><Q><M><P><K><K><D><W><Y><S><I><L><G><A><D><P><S><A><N><I><S><D><L><K><Q><K><Y><Q><K><L><I><L><M><Y><H><P><D><K><Q><S><T><D><V><P><A><G><T><V><E><E><C><V><Q><K><F><I><E><I><D><Q><A><W><K><I><L><G><N><E><E><T><K><R><E><Y><D><L><Q><R><C><E><D><D><L><R><N><V><G><P><V><D><A><Q><V><Y><L><E><E><M><S><W><N><E><G... | Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. The iron-bound form is redox-active and can function as electron carrier. Plays a role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor ... |
P48506 | <M><G><L><L><S><Q><G><S><P><L><S><W><E><E><T><K><R><H><A><D><H><V><R><R><H><G><I><L><Q><F><L><H><I><Y><H><A><V><K><D><R><H><K><D><V><L><K><W><G><D><E><V><E><Y><M><L><V><S><F><D><H><E><N><K><K><V><R><L><V><L><S><G><E><K><V><L><E><T><L><Q><E><K><G><E><R><T><N><P><N><H><P><T><L><W><R><P><E><Y><G><S><Y><M><I><E><G><T><P><G... | Catalyzes the ATP-dependent ligation of L-glutamate and L-cysteine and participates in the first and rate-limiting step in glutathione biosynthesis.<BOP> |
P01737 | <M><L><L><L><L><V><P><V><L><E><V><I><F><T><L><G><G><T><R><A><Q><S><V><T><Q><L><G><S><H><V><S><V><S><E><G><A><L><V><L><L><R><C><N><Y><S><S><S><V><P><P><Y><L><F><W><Y><V><Q><Y><P><N><Q><G><L><Q><L><L><L><K><Y><T><S><A><A><T><L><V><K><G><I><N><G><F><E><A><E><F><K><K><S><E><T><S><F><H><L><T><K><P><S><A><H><M><S><D><A><A><E... | V region of the variable domain of T cell receptor. Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility. Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering ... |
P55851 | <M><V><G><F><K><A><T><D><V><P><P><T><A><T><V><K><F><L><G><A><G><T><A><A><C><I><A><D><L><I><T><F><P><L><D><T><A><K><V><R><L><Q><I><Q><G><E><S><Q><G><P><V><R><A><T><A><S><A><Q><Y><R><G><V><M><G><T><I><L><T><M><V><R><T><E><G><P><R><S><L><Y><N><G><L><V><A><G><L><Q><R><Q><M><S><F><A><S><V><R><I><G><L><Y><D><S><V><K><Q><F><Y... | Antiporter that exports dicarboxylate intermediates of the Krebs cycle in exchange for phosphate plus a proton across the inner membrane of mitochondria, a process driven by mitochondrial motive force with an overall impact on glycolysis, glutaminolysis and glutathione-dependent redox balance. Continuous export of oxal... |
Q93063 | <M><C><A><S><V><K><Y><N><I><R><G><P><A><L><I><P><R><M><K><T><K><H><R><I><Y><Y><I><T><L><F><S><I><V><L><L><G><L><I><A><T><G><M><F><Q><F><W><P><H><S><I><E><S><S><N><D><W><N><V><E><K><R><S><I><R><D><V><P><V><V><R><L><P><A><D><S><P><I><P><E><R><G><D><L><S><C><R><M><H><T><C><F><D><V><Y><R><C><G><F><N><P><K><N><K><I><K><V><Y... | Glycosyltransferase forming with EXT1 the heterodimeric heparan sulfate polymerase which catalyzes the elongation of the heparan sulfate glycan backbone. Glycan backbone extension consists in the alternating transfer of. Heparan sulfate proteoglycans are ubiquitous components of the extracellular matrix and play an imp... |
Q9NQS3 | <M><A><R><T><L><R><P><S><P><L><C><P><G><G><G><K><A><Q><L><S><S><A><S><L><L><G><A><G><L><L><L><Q><P><P><T><P><P><P><L><L><L><L><L><F><P><L><L><L><F><S><R><L><C><G><A><L><A><G><P><I><I><V><E><P><H><V><T><A><V><W><G><K><N><V><S><L><K><C><L><I><E><V><N><E><T><I><T><Q><I><S><W><E><K><I><H><G><K><S><S><Q><T><V><A><V><H><H><P... | Cell adhesion molecule that promotes cell-cell adhesion through heterophilic trans-interactions with nectins-like or other nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Promotes formation ... |
Q56P42 | <M><A><S><S><A><E><L><D><F><N><L><Q><A><L><L><E><Q><L><S><Q><D><E><L><S><K><F><K><S><L><I><R><T><I><S><L><G><K><E><L><Q><T><V><P><Q><T><E><V><D><K><A><N><G><K><Q><L><V><E><I><F><T><S><H><S><C><S><Y><W><A><G><M><A><A><I><Q><V><F><E><K><M><N><Q><T><H><L><S><G><R><A><D><E><H><C><V><M><P><P><P> | May play a role in innate immunity by disrupting the interaction between PYCARD and NLRP3, thereby regulating the NLRP3 inflammasome. May also inhibit NF-kappa-B signaling distally by affecting the nuclear accumulation of RELA.<BOP> |
P41221 | <M><K><K><S><I><G><I><L><S><P><G><V><A><L><G><M><A><G><S><A><M><S><S><K><F><F><L><V><A><L><A><I><F><F><S><F><A><Q><V><V><I><E><A><N><S><W><W><S><L><G><M><N><N><P><V><Q><M><S><E><V><Y><I><I><G><A><Q><P><L><C><S><Q><L><A><G><L><S><Q><G><Q><K><K><L><C><H><L><Y><Q><D><H><M><Q><Y><I><G><E><G><A><K><T><G><I><K><E><C><Q><Y><Q... | Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through... |
Q14435 | <M><A><H><L><K><R><L><V><K><L><H><I><K><R><H><Y><H><K><K><F><W><K><L><G><A><V><I><F><F><F><I><I><V><L><V><L><M><Q><R><E><V><S><V><Q><Y><S><K><E><E><S><R><M><E><R><N><M><K><N><K><N><K><M><L><D><L><M><L><E><A><V><N><N><I><K><D><A><M><P><K><M><Q><I><G><A><P><V><R><Q><N><I><D><A><G><E><R><P><C><L><Q><G><Y><Y><T><A><A><E><L... | Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward HIV envelope glycoprotein gp120, EA2, MUC2, MUC1A and MUC5AC. Probably glycosylates fibronectin in vivo. Glycosylates... |
P23763 | <M><S><A><P><A><Q><P><P><A><E><G><T><E><G><T><A><P><G><G><G><P><P><G><P><P><P><N><M><T><S><N><R><R><L><Q><Q><T><Q><A><Q><V><E><E><V><V><D><I><I><R><V><N><V><D><K><V><L><E><R><D><Q><K><L><S><E><L><D><D><R><A><D><A><L><Q><A><G><A><S><Q><F><E><S><S><A><A><K><L><K><R><K><Y><W><W><K><N><C><K><M><M><I><M><L><G><A><I><C><A><I... | Involved in the targeting and/or fusion of transport vesicles to their target membrane.<BOP> |
A0A599 | <M><G><P><G><L><L><C><W><A><L><L><C><L><L><G><A><G><L><V><D><A><G><V><T><Q><S><P><T><H><L><I><K><T><R><G><Q><Q><V><T><L><R><C><S><P><K><S><G><H><D><T><V><S><W><Y><Q><Q><A><L><G><Q><G><P><Q><F><I><F><Q><Y><Y><E><E><E><E><R><Q><R><G><N><F><P><D><R><F><S><G><H><Q><F><P><N><Y><S><S><E><L><N><V><N><A><L><L><L><G><D><S><A><L... | V region of the variable domain of T cell receptor. Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility. Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering ... |
O43613 | <M><E><P><S><A><T><P><G><A><Q><M><G><V><P><P><G><S><R><E><P><S><P><V><P><P><D><Y><E><D><E><F><L><R><Y><L><W><R><D><Y><L><Y><P><K><Q><Y><E><W><V><L><I><A><A><Y><V><A><V><F><V><V><A><L><V><G><N><T><L><V><C><L><A><V><W><R><N><H><H><M><R><T><V><T><N><Y><F><I><V><N><L><S><L><A><D><V><L><V><T><A><I><C><L><P><A><S><L><L><V><D... | Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding.<BOP> |
Q9H8N7 | <M><A><S><V><L><S><R><R><L><G><K><R><S><L><L><G><A><R><V><L><G><P><S><A><S><E><G><P><S><A><A><P><P><S><E><P><L><L><E><G><A><A><P><Q><P><F><T><T><S><D><D><T><P><C><Q><E><Q><P><K><E><V><L><K><A><P><S><T><S><G><L><Q><Q><V><A><F><Q><P><G><Q><K><V><Y><V><W><Y><G><G><Q><E><C><T><G><L><V><E><Q><H><S><W><M><E><G><Q><V><T><V><W... | Plays a role in papillomavirus genes transcription.<BOP> |
P11844 | <M><G><K><I><T><F><Y><E><D><R><D><F><Q><G><R><C><Y><N><C><I><S><D><C><P><N><L><R><V><Y><F><S><R><C><N><S><I><R><V><D><S><G><C><W><M><L><Y><E><R><P><N><Y><Q><G><H><Q><Y><F><L><R><R><G><K><Y><P><D><Y><Q><H><W><M><G><L><S><D><S><V><Q><S><C><R><I><I><P><H><T><S><S><H><K><L><R><L><Y><E><R><D><D><Y><R><G><L><M><S><E><L><T><D... | Crystallins are the dominant structural components of the vertebrate eye lens.<BOP> |
Q16594 | <M><E><S><G><K><T><A><S><P><K><S><M><P><K><D><A><Q><M><M><A><Q><I><L><K><D><M><G><I><T><E><Y><E><P><R><V><I><N><Q><M><L><E><F><A><F><R><Y><V><T><T><I><L><D><D><A><K><I><Y><S><S><H><A><K><K><A><T><V><D><A><D><D><V><R><L><A><I><Q><C><R><A><D><Q><S><F><T><S><P><P><P><R><D><F><L><L><D><I><A><R><Q><R><N><Q><T><P><L><P><L><I... | The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex. The TFIID complex consists of TBP and TBP-associat... |
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