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353bf46 | 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 | # Incremental Value Of Sequence Counterfactual Features
Does adding the sequence counterfactual feature improve AUPRC over the
strongest trained molecular model, on identical matched rows? `adds_value`
is True only when the paired region-bootstrap 95% CI of (blend - trained)
is entirely above zero.
| panel | trained_model | scoreboard | auprc_trained | auprc_feature | auprc_blend | diff | ci_low | ci_high | adds_value |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| top250 | observed_hic_reabc | strict_all | 0.7278 | 0.6368 | 0.7107 | -0.0171 | -0.0374 | +0.0025 | False |
| top250 | observed_hic_reabc | high_confidence | 0.9159 | 0.8412 | 0.9015 | -0.0145 | -0.0345 | +0.0035 | False |
| top250 | observed_hic_reabc | field_compatible_e2g | 0.9380 | 0.8704 | 0.9266 | -0.0114 | -0.0312 | +0.0076 | False |
| top250 | observed_hic_reabc | very_high_confidence | 0.9264 | 0.8674 | 0.9138 | -0.0126 | -0.0374 | +0.0109 | False |
| top250 | ensemble_proxy_residual_v1 | strict_all | 0.7314 | 0.6368 | 0.7162 | -0.0152 | -0.0369 | +0.0055 | False |
| top250 | ensemble_proxy_residual_v1 | high_confidence | 0.9216 | 0.8412 | 0.9069 | -0.0147 | -0.0353 | +0.0037 | False |
| top250 | ensemble_proxy_residual_v1 | field_compatible_e2g | 0.9396 | 0.8704 | 0.9301 | -0.0095 | -0.0296 | +0.0096 | False |
| top250 | ensemble_proxy_residual_v1 | very_high_confidence | 0.9398 | 0.8674 | 0.9204 | -0.0194 | -0.0470 | +0.0080 | False |
| all_positive | observed_hic_reabc | strict_all | 0.6958 | 0.5885 | 0.6754 | -0.0203 | -0.0403 | +0.0011 | False |
| all_positive | observed_hic_reabc | high_confidence | 0.9044 | 0.8014 | 0.8772 | -0.0272 | -0.0460 | -0.0068 | False |
| all_positive | observed_hic_reabc | field_compatible_e2g | 0.9229 | 0.8235 | 0.8973 | -0.0256 | -0.0437 | -0.0085 | False |
| all_positive | observed_hic_reabc | very_high_confidence | 0.8858 | 0.8186 | 0.8770 | -0.0088 | -0.0420 | +0.0203 | False |
| all_positive | ensemble_proxy_residual_v1 | strict_all | 0.6872 | 0.5885 | 0.6752 | -0.0120 | -0.0325 | +0.0090 | False |
| all_positive | ensemble_proxy_residual_v1 | high_confidence | 0.9081 | 0.8014 | 0.8807 | -0.0274 | -0.0459 | -0.0081 | False |
| all_positive | ensemble_proxy_residual_v1 | field_compatible_e2g | 0.9227 | 0.8235 | 0.8995 | -0.0232 | -0.0415 | -0.0059 | False |
| all_positive | ensemble_proxy_residual_v1 | very_high_confidence | 0.9072 | 0.8186 | 0.8870 | -0.0202 | -0.0551 | +0.0126 | False | |