true_scfv_D70_CONTACTLOSS_A_sequences.json

{
  "chain_B_scfv": "EVQLVESGGGLVQPGGSLRLSCAASGFNIKDTYIHWVRQAPGKGLEWVARIYPTNGATRYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRWGGDGFYAMDYWGQGTLVTVSSGGGGSGGGGSGGGGSDIQMTQSPSSLSASVGDRVTITCRASQDVGTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQHYTTPPTFGQGTKVEIK",
  "chain_C_HER2_ECD": "TQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLSPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTATQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDSNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSIWKFPDEEGACQPCPIN",
  "candidate_id": "D70_CONTACTLOSS_A",
  "representation": "true_scfv",
  "linker_sequence": "GGGGSGGGGSGGGGS",
  "role": "D70_lead",
  "mutations_vs_wt": [
    "A:30 N->G",
    "B:57 Y->A"
  ],
  "mutations_vs_d70": [],
  "scfv_aware_remap_splitter_required": true,
  "linker_aware_contact_mask_required": true,
  "template": "true_scfv_wt_template.cif (WT paratope backbone; mutations are substitutions, forced by Boltz2)",
  "note": "true scFv D70_lead candidate; single-chain binder (VH-(G4S)3-VL) + HER2; same WT template, mutated sequence in input.yaml"
}