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true_scfv_var_s1_sequences.json
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{
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"candidate_id": "var_s1",
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"parent_id": "WT_SCFV",
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"representation": "true_scfv",
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"chain_B_scfv": "EVQLVESGGGLVQPGGSLRLSCAASGFNIKDTYIHWVRQAPGKGLEWVARIYPTNGNTRYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRWGGDGFYAMDYWGQGTLVTVSSGGGGSGGGGSGGGGSDIQMTQSPSSLSASVGDRVTITCRASQDVHTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQHYTTPPTFGQGTKVEIK",
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"chain_C_HER2_ECD": "TQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLSPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTATQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDSNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSIWKFPDEEGACQPCPIN",
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"linker_sequence": "GGGGSGGGGSGGGGS",
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"mutations_vs_wt": ["B:57 Y->N", "A:30 N->H"],
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"mutations_vs_d70": [],
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"scfv_aware_remap_splitter_required": true,
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"linker_aware_contact_mask_required": true,
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"source": "ProteinMPNN true scFv A30/B57 variation smoke (job 6a50b64d6d2b10c09d677a7b), sample 1",
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"validation_status": "UNVALIDATED_PENDING_BOLTZ2",
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"downstream_validation_required": true,
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"allowed_archive_update": false,
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"note": "ProteinMPNN-designed true scFv candidate; VH-(G4S)3-VL; 242 aa; linker intact; A30/B57 allowed mutations only; UNVALIDATED until Boltz2 + HER2 remap + scFv split + linker mask + C:591 + interface-quality validation passes"
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}
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