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## Model Description
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**HViLM (Human Virome Language Model)** is the first foundation model specifically designed for comprehensive viral risk assessment through multi-task prediction of pathogenicity, host tropism, and transmissibility. Built through continued pre-training of [DNABERT-2](https://github.com/MAGICS-LAB/DNABERT_2) on 5 million viral genome sequences from the [VIRION database](https://virion.verena.org), HViLM captures universal viral genomic patterns relevant for human disease risk assessment.
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**Paper**: *HViLM: A Foundation Model for Viral Genomics Enables Multi-Task Prediction of Pathogenicity, Transmissibility, and Host Tropism* (RECOMB 2026)
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**Authors**: Pratik Dutta, Jack Vaska, Pallavi Surana, Rekha Sathian, Max Chao, Zhihan Zhou, Han Liu, and Ramana V. Davuluri
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**Code & Benchmarks**: [GitHub Repository](https://github.com/duttaprat/HViLM)
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## Model Description
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**HViLM (Human Virome Language Model)** is the first foundation model specifically designed for comprehensive viral risk assessment through multi-task prediction of pathogenicity, host tropism, and transmissibility. Built through continued pre-training of [DNABERT-2](https://github.com/MAGICS-LAB/DNABERT_2) on 5 million viral genome sequences from the [VIRION database](https://virion.verena.org), HViLM captures universal viral genomic patterns relevant for human disease risk assessment.
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**Paper**: *HViLM: A Foundation Model for Viral Genomics Enables Multi-Task Prediction of Pathogenicity, Transmissibility, and Host Tropism* (RECOMB 2026)
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**Authors**: Pratik Dutta, Jack Vaska, Pallavi Surana, Rekha Sathian, Max Chao, Zhihan Zhou, Han Liu, and Ramana V. Davuluri
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**Code & Benchmarks**: [GitHub Repository](https://github.com/duttaprat/HViLM)
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