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  <!-- Provide a quick summary of what the model is/does. -->
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- Post-Translational Modifications (PTMs) are a fundamental mechanism for regulating cellular functions and increasing the functional diversity of the proteome.
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- Despite the identification of hundreds of unique PTMs through mass-spectrometry (MS) studies, accurately predicting many PTM types based on sequence data alone
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- remains a significant challenge. Existing PTM prediction models predominantly focus on either single PTM types or employ ensemble methods that combine multiple
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- models to predict different PTM types. This fragmentation is largely drivenby the vast imbalance in data availability across PTM types making it difficult to
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- predict multiple PTM types with a single model. To address this limitation, we present the Contrastively Learned Attention-Based Stratified PTM Predictor (CLASPP),
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- aunified PTM prediction model. CLASPP overcomes data imbalance challenges by leveraging unsupervised clustering-based under-sampling and incorporating a novel
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- contrastive learning framework tailored to PTM data. Drawing inspiration from advancements in image and natural language processing, the CLASPP model employs
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- a multi-stage training strategy and utilizes a high-quality curated training datasetto improve PTM prediction accuracy compared to existing multi-PTM prediction
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- models. Existing PTM prediction models predominantly focuson either single PTM types or employ ensemble methods that combine multiple
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- models to predict different PTM types. This fragmentation is largely driven by the vast imbalance in data availability across PTM types making it difficult to
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- predict multiple PTM types with a single model. To address this limitation, we present the Contrastively Learned Attention-Based Stratified PTM Predictor (CLASPP),
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- aunified PTM prediction model.
 
 
 
 
 
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  <!-- Provide a quick summary of what the model is/does. -->
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+ Post-Translational Modifications (PTMs) are a fundamental mechanism for regulating cellular functions and
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+ increasing the functional diversity of the proteome. Despite the identification of hundreds of unique PTMs
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+ through mass-spectrometry (MS) studies, accurately predicting many PTM types based on sequence data alone
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+ remains a significant challenge. Existing PTM prediction models predominantly focuson either single PTM
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+ types or employ ensemble methods that combine multiple models to predict different PTM types. This fragmentation
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+ is largely drivenby the vast imbalance in data availability across PTM types making it difficult to predict
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+ multiple PTM types with a single model. To address this limitation, we present the Contrastively Learned
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+ Attention-Based Stratified PTM Predictor (CLASPP), a unified PTM prediction model. CLASPP overcomes
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+ data imbalance challenges by leveragingunsupervised clustering-based under-sampling and incorporating a novel
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+ contrastive learning framework tailored to PTM data. Drawing inspiration from advancements in image and
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+ natural language processing, the CLASPP model employs a multi-stage training strategy and utilizes a
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+ high-quality curated training datasetto improve PTM prediction accuracy compared to existing multi-PTM prediction
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+ models. Existing PTM prediction models predominantly focus on either single PTM types or employ ensemble methods
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+ that combine multiple models to predict different PTM types. This fragmentation is largely driven by the
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+ vast imbalance in data availability across PTM types making it difficult to predict multiple PTM types
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+ with a single model. To address this limitation, we present the
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+ Contrastively Learned Attention-Based Stratified PTM Predictor (CLASPP), a unified PTM prediction model.
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