[
  {
    "COADD_ID":"CO-ADD:0161340",
    "INHIB_AVE":16.14,
    "SMILES":"C1(C#N)=C(N)OC(=C2C1c(ccc(c3[N+](=O)[O-])Cl)c3)CCCC2=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C1(C#N)=C(N)OC(=C2C1c(ccc(c3[N+](=O)[O-])Cl)c3)CCCC2=O?",
    "answer":"No",
    "_id":6199
  },
  {
    "COADD_ID":"CO-ADD:0157725",
    "INHIB_AVE":8.07,
    "SMILES":"O=C(COC1=CC=CC=C1C)N\/N=C\/C2=CN(C3=C2C=CC=C3)C",
    "HIT":0.0,
    "question":"Can O=C(COC1=CC=CC=C1C)N\/N=C\/C2=CN(C3=C2C=CC=C3)C act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":22956
  },
  {
    "COADD_ID":"CO-ADD:0257782",
    "INHIB_AVE":9.98,
    "SMILES":"C(=N\/c(cc1)ccc1OC)(\/S\\C(\\C2=O)=C\/c3c(OC)ccc(cccc4)c34)\\N2",
    "HIT":0.0,
    "question":"Is C(=N\/c(cc1)ccc1OC)(\/S\\C(\\C2=O)=C\/c3c(OC)ccc(cccc4)c34)\\N2 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":17033
  },
  {
    "COADD_ID":"CO-ADD:0324351",
    "INHIB_AVE":12.47,
    "SMILES":"S(=O)(=O)(NCc1ccccn1)c(c(C)ccc2c(c(cccc3)c34)nnc4N(CC5)CCO5)c2",
    "HIT":0.0,
    "question":"Can S(=O)(=O)(NCc1ccccn1)c(c(C)ccc2c(c(cccc3)c34)nnc4N(CC5)CCO5)c2 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":11529
  },
  {
    "COADD_ID":"CO-ADD:0278219",
    "INHIB_AVE":-2.62,
    "SMILES":"S1(=O)(=O)c(cccc2)c2C(N(C)c3ccc(cc3)OC(=O)c(cc4OC)cc(c4OC)OC)=N1",
    "HIT":0.0,
    "question":"Can S1(=O)(=O)c(cccc2)c2C(N(C)c3ccc(cc3)OC(=O)c(cc4OC)cc(c4OC)OC)=N1 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":66177
  },
  {
    "COADD_ID":"CO-ADD:0225295",
    "INHIB_AVE":10.41,
    "SMILES":"C1(=N2)N(c3c(cccc3)N=C1Oc(cc4)ccc4C)C(N2CC(=O)Nc(cccc5C(F)(F)F)c5)=O",
    "HIT":0.0,
    "question":"Does C1(=N2)N(c3c(cccc3)N=C1Oc(cc4)ccc4C)C(N2CC(=O)Nc(cccc5C(F)(F)F)c5)=O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":15946
  },
  {
    "COADD_ID":"CO-ADD:0159869",
    "INHIB_AVE":-7.63,
    "SMILES":"S=C1NC(\/C=C\/C2=CC=CC=C2)C(C(OCC)=O)=C(C)N1",
    "HIT":0.0,
    "question":"Is S=C1NC(\/C=C\/C2=CC=CC=C2)C(C(OCC)=O)=C(C)N1 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":76236
  },
  {
    "COADD_ID":"CO-ADD:0236848",
    "INHIB_AVE":1.4,
    "SMILES":"[N+](=O)([O-])c1cc(ccc1Sc2cccc3c2cccn3)\\C=N\\NC(CCCC)=O",
    "HIT":0.0,
    "question":"Can [N+](=O)([O-])c1cc(ccc1Sc2cccc3c2cccn3)\\C=N\\NC(CCCC)=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":51715
  },
  {
    "COADD_ID":"CO-ADD:0331468",
    "INHIB_AVE":5.24,
    "SMILES":"c1(nc(c2ccccc2OC)cc3C(F)F)n3ncc1C(=O)OCC4CCCN5C4CCCC5",
    "HIT":0.0,
    "question":"Can c1(nc(c2ccccc2OC)cc3C(F)F)n3ncc1C(=O)OCC4CCCN5C4CCCC5 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":34567
  },
  {
    "COADD_ID":"CO-ADD:0223133",
    "INHIB_AVE":13.98,
    "SMILES":"C(=C\\c(cc1)ccc1N(C)C)(\/NC(c2ccccc2)=O)\\C(=O)N\\N=C\\c(ccc(c3I)OC)c3",
    "HIT":0.0,
    "question":"Can exposure to C(=C\\c(cc1)ccc1N(C)C)(\/NC(c2ccccc2)=O)\\C(=O)N\\N=C\\c(ccc(c3I)OC)c3 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":9075
  },
  {
    "COADD_ID":"CO-ADD:0156020",
    "INHIB_AVE":-13.13,
    "SMILES":"O=C1C2=C(C3=C1C=CC=C3)C(C(N4CCCCCC4)=O)=CC=C2",
    "HIT":0.0,
    "question":"Does treatment with O=C1C2=C(C3=C1C=CC=C3)C(C(N4CCCCCC4)=O)=CC=C2 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":80572
  },
  {
    "COADD_ID":"CO-ADD:0284253",
    "INHIB_AVE":-6.02,
    "SMILES":"c1([N+](=O)[O-])nn(c(C)c1Cl)Cc2cc(ccc2OC)\\C=N\\NC(=O)c(nnn3c4nonc4N)c3C",
    "HIT":0.0,
    "question":"Can exposure to c1([N+](=O)[O-])nn(c(C)c1Cl)Cc2cc(ccc2OC)\\C=N\\NC(=O)c(nnn3c4nonc4N)c3C lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":73768
  },
  {
    "COADD_ID":"CO-ADD:0286818",
    "INHIB_AVE":2.45,
    "SMILES":"c1(NC(=O)c(cccc2C(F)(F)F)c2)sc(c3c1C(OC)=O)CCCCCC3",
    "HIT":0.0,
    "question":"Is c1(NC(=O)c(cccc2C(F)(F)F)c2)sc(c3c1C(OC)=O)CCCCCC3 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":47101
  },
  {
    "COADD_ID":"CO-ADD:0215767",
    "INHIB_AVE":-5.12,
    "SMILES":"N1(c2cccc(C)c2)C(=O)CC(N(CC3)CCN3c4ccc(cc4)Cl)C1=O",
    "HIT":0.0,
    "question":"Is N1(c2cccc(C)c2)C(=O)CC(N(CC3)CCN3c4ccc(cc4)Cl)C1=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":72095
  },
  {
    "COADD_ID":"CO-ADD:0162420",
    "INHIB_AVE":-7.52,
    "SMILES":"C(=O)(c1ccc(cc1)NC(=O)c2ccc(cc2)NC(CCCCC)=O)Nc3ccccc3C",
    "HIT":0.0,
    "question":"Does the proposed molecule C(=O)(c1ccc(cc1)NC(=O)c2ccc(cc2)NC(CCCCC)=O)Nc3ccccc3C exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":76092
  },
  {
    "COADD_ID":"CO-ADD:0227240",
    "INHIB_AVE":-3.66,
    "SMILES":"c1(NCC(=O)N\\N=C(\/C)\\c2ccc(cc2OC)OC)c(Br)cc(cc1Br)Br",
    "HIT":0.0,
    "question":"Can c1(NCC(=O)N\\N=C(\/C)\\c2ccc(cc2OC)OC)c(Br)cc(cc1Br)Br effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":68926
  },
  {
    "COADD_ID":"CO-ADD:0231499",
    "INHIB_AVE":1.58,
    "SMILES":"c1(oc(c2n1)ccc(c2)\\N=C\\c3cc(Br)ccc3O)c4ccc(cc4Cl)F",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(oc(c2n1)ccc(c2)\\N=C\\c3cc(Br)ccc3O)c4ccc(cc4Cl)F?",
    "answer":"No",
    "_id":50941
  },
  {
    "COADD_ID":"CO-ADD:0149847",
    "INHIB_AVE":1.5,
    "SMILES":"BrC(\/C(OC1=C2C(C=CC=C3)=C3C=C1)=NBr)(C2C4=CC(OC)=CC=C4)C#N",
    "HIT":0.0,
    "question":"Does treatment with BrC(\/C(OC1=C2C(C=CC=C3)=C3C=C1)=NBr)(C2C4=CC(OC)=CC=C4)C#N result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":51299
  },
  {
    "COADD_ID":"CO-ADD:0232073",
    "INHIB_AVE":1.38,
    "SMILES":"c(\\C=N\\NC(COc1ccccc1C)=O)(cc(Br)cc2I)c2O",
    "HIT":0.0,
    "question":"Does c(\\C=N\\NC(COc1ccccc1C)=O)(cc(Br)cc2I)c2O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":51843
  },
  {
    "COADD_ID":"CO-ADD:0286367",
    "INHIB_AVE":2.46,
    "SMILES":"S(=O)(=O)(c(cc1)ccc1C2=CS\\C(=N\/c(cc3)ccc3C)\\N2C)N4CCCC4.Br",
    "HIT":0.0,
    "question":"Is S(=O)(=O)(c(cc1)ccc1C2=CS\\C(=N\/c(cc3)ccc3C)\\N2C)N4CCCC4.Br capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":47066
  },
  {
    "COADD_ID":"CO-ADD:0300040",
    "INHIB_AVE":14.33,
    "SMILES":"C(C#N)(C(c1ccccc1OCC)C2C(OCC)=O)=C(SCC(=O)Nc(cc3)ccc3Br)NC2=O",
    "HIT":0.0,
    "question":"Can exposure to C(C#N)(C(c1ccccc1OCC)C2C(OCC)=O)=C(SCC(=O)Nc(cc3)ccc3Br)NC2=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":8518
  },
  {
    "COADD_ID":"CO-ADD:0304637",
    "INHIB_AVE":5.39,
    "SMILES":"S(c1ccccc1)(=O)(=O)Oc2c(OC)cc(cc2OC)C=O",
    "HIT":0.0,
    "question":"Is S(c1ccccc1)(=O)(=O)Oc2c(OC)cc(cc2OC)C=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":33963
  },
  {
    "COADD_ID":"CO-ADD:0330820",
    "INHIB_AVE":6.61,
    "SMILES":"c1(sc2c(c(COC)cc(C)n2)c1n3cccc3)C(=O)N(c4ccccc4)c5ccccc5",
    "HIT":0.0,
    "question":"Does treatment with c1(sc2c(c(COC)cc(C)n2)c1n3cccc3)C(=O)N(c4ccccc4)c5ccccc5 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":28685
  },
  {
    "COADD_ID":"CO-ADD:0307548",
    "INHIB_AVE":12.25,
    "SMILES":"c12c(cc(C)c(C)c1)NC(CC2c3ccccc3OC)=O",
    "HIT":0.0,
    "question":"Does c12c(cc(C)c(C)c1)NC(CC2c3ccccc3OC)=O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":11964
  },
  {
    "COADD_ID":"CO-ADD:0154820",
    "INHIB_AVE":16.12,
    "SMILES":"O=C(CC1=CC=CC=C1)NC2=CC=C(C=C2)C3=NC4=CC=CC=C4C(C5=CC=C(C=C5)C6=NC(C(C=C7)=CC=C7NC(CC8=CC=CC=C8)=O)=NC9=CC=CC=C69)=N3",
    "HIT":0.0,
    "question":"Does treatment with O=C(CC1=CC=CC=C1)NC2=CC=C(C=C2)C3=NC4=CC=CC=C4C(C5=CC=C(C=C5)C6=NC(C(C=C7)=CC=C7NC(CC8=CC=CC=C8)=O)=NC9=CC=CC=C69)=N3 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":6231
  },
  {
    "COADD_ID":"CO-ADD:0291273",
    "INHIB_AVE":13.26,
    "SMILES":"C1(CC(C2C(O)=O)C=C1)C2C(OCC#C)=O",
    "HIT":0.0,
    "question":"Is C1(CC(C2C(O)=O)C=C1)C2C(OCC#C)=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":10152
  },
  {
    "COADD_ID":"CO-ADD:0253686",
    "INHIB_AVE":-3.98,
    "SMILES":"S1(=O)(=O)c(cccc2)c2C(NNC(=O)c3ccccc3S(NC)(=O)=O)=N1",
    "HIT":0.0,
    "question":"Can exposure to S1(=O)(=O)c(cccc2)c2C(NNC(=O)c3ccccc3S(NC)(=O)=O)=N1 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":69697
  },
  {
    "COADD_ID":"CO-ADD:0256619",
    "INHIB_AVE":-2.19,
    "SMILES":"S(c1ccccc1)(=O)(=O)N(CC(=O)N\\N=C(\/CCC2)\\C2C(OCC)=O)c3c(OC)ccc(OC)c3",
    "HIT":0.0,
    "question":"Does S(c1ccccc1)(=O)(=O)N(CC(=O)N\\N=C(\/CCC2)\\C2C(OCC)=O)c3c(OC)ccc(OC)c3 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":64946
  },
  {
    "COADD_ID":"CO-ADD:0312300",
    "INHIB_AVE":9.14,
    "SMILES":"c1(ccccc1F)C(NCCOc(cc2)ccc2C)=O",
    "HIT":0.0,
    "question":"Does treatment with c1(ccccc1F)C(NCCOc(cc2)ccc2C)=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":19477
  },
  {
    "COADD_ID":"CO-ADD:0163955",
    "INHIB_AVE":10.93,
    "SMILES":"C(=C\/c(cc1)ccc1[N+](=O)[O-])(\/C(=O)N\\N=C\\c(cc2)ccc2[N+](=O)[O-])\\C(=O)N\\N=C\\c(cc3)ccc3[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Is C(=C\/c(cc1)ccc1[N+](=O)[O-])(\/C(=O)N\\N=C\\c(cc2)ccc2[N+](=O)[O-])\\C(=O)N\\N=C\\c(cc3)ccc3[N+](=O)[O-] effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":14673
  },
  {
    "COADD_ID":"CO-ADD:0311150",
    "INHIB_AVE":9.27,
    "SMILES":"C(=C\\c1ccccc1)(\/NC(c2ccccc2)=O)\\C(=O)N(CC3)CCC3C(N)=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C(=C\\c1ccccc1)(\/NC(c2ccccc2)=O)\\C(=O)N(CC3)CCC3C(N)=O?",
    "answer":"No",
    "_id":19132
  },
  {
    "COADD_ID":"CO-ADD:0294838",
    "INHIB_AVE":-6.21,
    "SMILES":"c1(CC2(C)C)c(ccc(cccc3)c13)C(=N2)CCl",
    "HIT":0.0,
    "question":"Can c1(CC2(C)C)c(ccc(cccc3)c13)C(=N2)CCl act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":74122
  },
  {
    "COADD_ID":"CO-ADD:0277390",
    "INHIB_AVE":14.49,
    "SMILES":"C(=N\\c1ccccc1)(\/S\\C(\\C2=O)=C\\c(ccc3c(ccc(c4C(O)=O)Cl)c4)o3)\\N2C5CCCCC5",
    "HIT":0.0,
    "question":"Can C(=N\\c1ccccc1)(\/S\\C(\\C2=O)=C\\c(ccc3c(ccc(c4C(O)=O)Cl)c4)o3)\\N2C5CCCCC5 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":8267
  },
  {
    "COADD_ID":"CO-ADD:0320979",
    "INHIB_AVE":12.38,
    "SMILES":"N(Cc1ccccc1)(C(=O)c(cc2)ccc2n3cnnn3)C4(CCCC4)C(=O)Nc5c(C)cccc5C",
    "HIT":0.0,
    "question":"Is N(Cc1ccccc1)(C(=O)c(cc2)ccc2n3cnnn3)C4(CCCC4)C(=O)Nc5c(C)cccc5C capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":11696
  },
  {
    "COADD_ID":"CO-ADD:0328209",
    "INHIB_AVE":6.68,
    "SMILES":"S(=O)(=O)(c1ccc(cc1)Cl)c2cc(cc(C)c2O)NS(c3ccccc3)(=O)=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound S(=O)(=O)(c1ccc(cc1)Cl)c2cc(cc(C)c2O)NS(c3ccccc3)(=O)=O?",
    "answer":"No",
    "_id":28356
  },
  {
    "COADD_ID":"CO-ADD:0283089",
    "INHIB_AVE":-4.49,
    "SMILES":"c1(c2c3c(cccc3)cc(cccc4)c24)[nH]c(c(c5ccc(cc5)OC)n1)c6ccc(cc6)OC",
    "HIT":0.0,
    "question":"Can exposure to c1(c2c3c(cccc3)cc(cccc4)c24)[nH]c(c(c5ccc(cc5)OC)n1)c6ccc(cc6)OC lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":70823
  },
  {
    "COADD_ID":"CO-ADD:0295612",
    "INHIB_AVE":1.85,
    "SMILES":"C1(C(F)(F)F)(C(F)(F)F)C(C)=C(CC)N(C(N)=C1C#N)c2ccccc2F",
    "HIT":0.0,
    "question":"Is C1(C(F)(F)F)(C(F)(F)F)C(C)=C(CC)N(C(N)=C1C#N)c2ccccc2F effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":49784
  },
  {
    "COADD_ID":"CO-ADD:0284925",
    "INHIB_AVE":-1.28,
    "SMILES":"c12c(nnc(SCC(=O)Nc3sccn3)n1)c4c(cccc4)n2CC",
    "HIT":0.0,
    "question":"Can c12c(nnc(SCC(=O)Nc3sccn3)n1)c4c(cccc4)n2CC effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":61994
  },
  {
    "COADD_ID":"CO-ADD:0161324",
    "INHIB_AVE":4.18,
    "SMILES":"C1(C2c3ccc(cc3Cl)Cl)=C(c4c(cccc4)OC1=O)OC(N)=C2C(OCC)=O",
    "HIT":0.0,
    "question":"Can C1(C2c3ccc(cc3Cl)Cl)=C(c4c(cccc4)OC1=O)OC(N)=C2C(OCC)=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":39343
  },
  {
    "COADD_ID":"CO-ADD:0284708",
    "INHIB_AVE":-9.49,
    "SMILES":"N#Cc(cc1)ccc1\\C=N\\NC(CNc(ccc(c23)OCO2)c3)=O",
    "HIT":0.0,
    "question":"Does N#Cc(cc1)ccc1\\C=N\\NC(CNc(ccc(c23)OCO2)c3)=O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":78308
  },
  {
    "COADD_ID":"CO-ADD:0233432",
    "INHIB_AVE":10.17,
    "SMILES":"c(cc(Br)cc1Cl)(\\C=N\\c(cc2)ccc2Cl)c1O",
    "HIT":0.0,
    "question":"Can c(cc(Br)cc1Cl)(\\C=N\\c(cc2)ccc2Cl)c1O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":16583
  },
  {
    "COADD_ID":"CO-ADD:0247735",
    "INHIB_AVE":-2.64,
    "SMILES":"S(=O)(=O)(\\C=C\\c1ccccc1)Nc2ccccc2OC",
    "HIT":0.0,
    "question":"Is S(=O)(=O)(\\C=C\\c1ccccc1)Nc2ccccc2OC effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":66215
  },
  {
    "COADD_ID":"CO-ADD:0283972",
    "INHIB_AVE":9.97,
    "SMILES":"C(C(=O)OC(C)C)(=C(C)NC(=C12)CC(CC1=O)c3ccc(cc3)Cl)C2c4ccc(c(OCC)c4)OC(C)=O",
    "HIT":0.0,
    "question":"Can exposure to C(C(=O)OC(C)C)(=C(C)NC(=C12)CC(CC1=O)c3ccc(cc3)Cl)C2c4ccc(c(OCC)c4)OC(C)=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":17081
  },
  {
    "COADD_ID":"CO-ADD:0256528",
    "INHIB_AVE":-3.85,
    "SMILES":"S(c1ccccc1)(=O)(=O)Nc2ccc(c(cccc3)c23)O",
    "HIT":0.0,
    "question":"Does S(c1ccccc1)(=O)(=O)Nc2ccc(c(cccc3)c23)O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":69395
  },
  {
    "COADD_ID":"CO-ADD:0252601",
    "INHIB_AVE":-14.99,
    "SMILES":"N(\\C(=C\/c1ccco1)\\C(O2)=O)=C2c(cc3)ccc3C4=N\\C(\\C(=O)O4)=C\/c5ccco5",
    "HIT":0.0,
    "question":"Can N(\\C(=C\/c1ccco1)\\C(O2)=O)=C2c(cc3)ccc3C4=N\\C(\\C(=O)O4)=C\/c5ccco5 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":81292
  },
  {
    "COADD_ID":"CO-ADD:0254021",
    "INHIB_AVE":1.23,
    "SMILES":"N1(C2c3ccc(c(OC)c3)OC)C(S\\C(=C\\c(cc4OC)cc(c4OCc5cccc(cccc6)c56)I)\\C1=O)=NC(C)=C2C(OCC)=O",
    "HIT":0.0,
    "question":"Can exposure to N1(C2c3ccc(c(OC)c3)OC)C(S\\C(=C\\c(cc4OC)cc(c4OCc5cccc(cccc6)c56)I)\\C1=O)=NC(C)=C2C(OCC)=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":52452
  },
  {
    "COADD_ID":"CO-ADD:0320920",
    "INHIB_AVE":4.38,
    "SMILES":"S(C)(=O)(=O)N(CC1)CCN1c(cc2)cc(c2[N+](=O)[O-])N3CCc(c4C3)cccc4",
    "HIT":0.0,
    "question":"Does S(C)(=O)(=O)N(CC1)CCN1c(cc2)cc(c2[N+](=O)[O-])N3CCc(c4C3)cccc4 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":38441
  },
  {
    "COADD_ID":"CO-ADD:0332523",
    "INHIB_AVE":5.23,
    "SMILES":"[N+](=O)([O-])c1ccc(cc1NCc2ccco2)N(CC3)CCN3C(=O)c4cccs4",
    "HIT":0.0,
    "question":"Does treatment with [N+](=O)([O-])c1ccc(cc1NCc2ccco2)N(CC3)CCN3C(=O)c4cccs4 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":34608
  },
  {
    "COADD_ID":"CO-ADD:0301125",
    "INHIB_AVE":-11.18,
    "SMILES":"N1(Nc2c(F)c(F)c(c(F)c2F)F)\\C(=N\\c(cc3)ccc3Cl)\\SC(C(=O)Nc(cc4)ccc4C(OC)=O)CC1=O",
    "HIT":0.0,
    "question":"Can N1(Nc2c(F)c(F)c(c(F)c2F)F)\\C(=N\\c(cc3)ccc3Cl)\\SC(C(=O)Nc(cc4)ccc4C(OC)=O)CC1=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":79536
  },
  {
    "COADD_ID":"CO-ADD:0248887",
    "INHIB_AVE":-2.46,
    "SMILES":"N(CCc(c12)cccc1)(Cc(cc3)ccc3C(=O)N\\N=C\\c4cccc(Cl)c4)C2",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound N(CCc(c12)cccc1)(Cc(cc3)ccc3C(=O)N\\N=C\\c4cccc(Cl)c4)C2?",
    "answer":"No",
    "_id":65718
  },
  {
    "COADD_ID":"CO-ADD:0286903",
    "INHIB_AVE":14.36,
    "SMILES":"C12(c(cccc3)c3C(c4ccc(cc4)Br)(c5ccc(cc5)Br)S1)N(c6ccc(cc6)Br)N=C(C(OCC)=O)S2",
    "HIT":0.0,
    "question":"Does treatment with C12(c(cccc3)c3C(c4ccc(cc4)Br)(c5ccc(cc5)Br)S1)N(c6ccc(cc6)Br)N=C(C(OCC)=O)S2 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":8486
  },
  {
    "COADD_ID":"CO-ADD:0312177",
    "INHIB_AVE":-0.04,
    "SMILES":"S(=O)(=O)(c1ccc(cc1)Br)N(CC2)CCN2c3ccc(cc3[N+](=O)[O-])C(F)(F)F",
    "HIT":0.0,
    "question":"Can S(=O)(=O)(c1ccc(cc1)Br)N(CC2)CCN2c3ccc(cc3[N+](=O)[O-])C(F)(F)F effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":57666
  },
  {
    "COADD_ID":"CO-ADD:0323685",
    "INHIB_AVE":0.0,
    "SMILES":"n1cn[nH]c1SCc2ccccc2",
    "HIT":0.0,
    "question":"Does n1cn[nH]c1SCc2ccccc2 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":57440
  },
  {
    "COADD_ID":"CO-ADD:0277506",
    "INHIB_AVE":5.29,
    "SMILES":"c12c(n(c(SCC(=O)Nc(cc3)ccc3F)n1)C)C(N(C)C(=O)N2C)=O",
    "HIT":0.0,
    "question":"Can c12c(n(c(SCC(=O)Nc(cc3)ccc3F)n1)C)C(N(C)C(=O)N2C)=O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":34358
  },
  {
    "COADD_ID":"CO-ADD:0326763",
    "INHIB_AVE":4.25,
    "SMILES":"c(cn(n1)c2ccc(cc2)Cl)(c(c3ccco3)nnc4c5sc(c6n5)cccc6)c14",
    "HIT":0.0,
    "question":"Does c(cn(n1)c2ccc(cc2)Cl)(c(c3ccco3)nnc4c5sc(c6n5)cccc6)c14 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":39027
  },
  {
    "COADD_ID":"CO-ADD:0249299",
    "INHIB_AVE":1.27,
    "SMILES":"C(=C\\c(cc1)ccc1[N+](=O)[O-])(\/C=C(O2)c3ccccc3)\\C2=O",
    "HIT":0.0,
    "question":"Does C(=C\\c(cc1)ccc1[N+](=O)[O-])(\/C=C(O2)c3ccccc3)\\C2=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":52279
  },
  {
    "COADD_ID":"CO-ADD:0234123",
    "INHIB_AVE":8.23,
    "SMILES":"C1(NC(=O)c2ccccc2c3ccccc3)=C(C)N(N(c4ccccc4)C1=O)C",
    "HIT":0.0,
    "question":"Does C1(NC(=O)c2ccccc2c3ccccc3)=C(C)N(N(c4ccccc4)C1=O)C show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":22380
  },
  {
    "COADD_ID":"CO-ADD:0284890",
    "INHIB_AVE":19.78,
    "SMILES":"C(C)(NN=C1C(OC)=O)(C2=O)C1C(N2c3cccc(C)c3)=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C(C)(NN=C1C(OC)=O)(C2=O)C1C(N2c3cccc(C)c3)=O?",
    "answer":"No",
    "_id":3007
  },
  {
    "COADD_ID":"CO-ADD:0292090",
    "INHIB_AVE":2.59,
    "SMILES":"N1(c2ccccc2OC)C(=O)c3c(c(ccc4N5CCCCC5)C1=O)c4ccc3",
    "HIT":0.0,
    "question":"Does N1(c2ccccc2OC)C(=O)c3c(c(ccc4N5CCCCC5)C1=O)c4ccc3 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":46455
  },
  {
    "COADD_ID":"CO-ADD:0242237",
    "INHIB_AVE":-7.75,
    "SMILES":"[N+](=O)([O-])c(cccc1c2ccc(\\C=N\\NC(N)=S)o2)c1",
    "HIT":0.0,
    "question":"Is [N+](=O)([O-])c(cccc1c2ccc(\\C=N\\NC(N)=S)o2)c1 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":76419
  },
  {
    "COADD_ID":"CO-ADD:0312599",
    "INHIB_AVE":-0.08,
    "SMILES":"C1=C[C@]2(O[C@H]13)[C@]([C@]4(CN(C2)C(=O)c5ccccc5)O[C@H]6C=C4)([C@@]36C(F)(F)F)C(F)(F)F",
    "HIT":0.0,
    "question":"Does C1=C[C@]2(O[C@H]13)[C@]([C@]4(CN(C2)C(=O)c5ccccc5)O[C@H]6C=C4)([C@@]36C(F)(F)F)C(F)(F)F show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":57781
  },
  {
    "COADD_ID":"CO-ADD:0160178",
    "INHIB_AVE":4.12,
    "SMILES":"O=C(CCCC(O)=O)NC1=CC=C(C=C1)C2=NC(C=C3)=C(C=C3C)S2",
    "HIT":0.0,
    "question":"Can O=C(CCCC(O)=O)NC1=CC=C(C=C1)C2=NC(C=C3)=C(C=C3C)S2 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":39637
  },
  {
    "COADD_ID":"CO-ADD:0292943",
    "INHIB_AVE":4.43,
    "SMILES":"c1(c(cccc1N)Cl)C(O)=O.Cl",
    "HIT":0.0,
    "question":"Is c1(c(cccc1N)Cl)C(O)=O.Cl effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":38251
  },
  {
    "COADD_ID":"CO-ADD:0331245",
    "INHIB_AVE":-1.18,
    "SMILES":"c12c(cc(cc1[N+](=O)[O-])SCc3ccccc3)Oc(c4NC2=O)cccc4",
    "HIT":0.0,
    "question":"Does treatment with c12c(cc(cc1[N+](=O)[O-])SCc3ccccc3)Oc(c4NC2=O)cccc4 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":61689
  },
  {
    "COADD_ID":"CO-ADD:0291292",
    "INHIB_AVE":0.49,
    "SMILES":"C12(C(OC)=O)C(C(C(=O)N1c(cccc3C(F)(F)F)c3)=O)=C(c4ccccc4)Nc(cccc5)c5N2",
    "HIT":0.0,
    "question":"Does C12(C(OC)=O)C(C(C(=O)N1c(cccc3C(F)(F)F)c3)=O)=C(c4ccccc4)Nc(cccc5)c5N2 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":55516
  },
  {
    "COADD_ID":"CO-ADD:0278979",
    "INHIB_AVE":-0.22,
    "SMILES":"n1(nnc(C)c1C(=O)NNC(=O)c(ccc(c2Cl)Cl)c2)c3nonc3N",
    "HIT":0.0,
    "question":"Does n1(nnc(C)c1C(=O)NNC(=O)c(ccc(c2Cl)Cl)c2)c3nonc3N show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":58336
  },
  {
    "COADD_ID":"CO-ADD:0227453",
    "INHIB_AVE":6.35,
    "SMILES":"C1=C(C)\\C(\\CCC1C(C)=C)=N\/NC(CNc2cccc(Br)c2)=O",
    "HIT":0.0,
    "question":"Does C1=C(C)\\C(\\CCC1C(C)=C)=N\/NC(CNc2cccc(Br)c2)=O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":29764
  },
  {
    "COADD_ID":"CO-ADD:0233514",
    "INHIB_AVE":-4.92,
    "SMILES":"[N+](=O)([O-])c(ccc(c1\\C=N\\NC(COc2ccccc2C)=O)N(CC(C)C)CC(C)C)c1",
    "HIT":0.0,
    "question":"Can exposure to [N+](=O)([O-])c(ccc(c1\\C=N\\NC(COc2ccccc2C)=O)N(CC(C)C)CC(C)C)c1 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":71712
  },
  {
    "COADD_ID":"CO-ADD:0247400",
    "INHIB_AVE":2.69,
    "SMILES":"S(=O)(=O)(c1ccc(cc1)C)N2CCC(CC2)C(=O)N\\N=C\\c3cccc(Cl)c3Cl",
    "HIT":0.0,
    "question":"Can exposure to S(=O)(=O)(c1ccc(cc1)C)N2CCC(CC2)C(=O)N\\N=C\\c3cccc(Cl)c3Cl lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":46010
  },
  {
    "COADD_ID":"CO-ADD:0293042",
    "INHIB_AVE":0.6,
    "SMILES":"N1(c2ccc(cc2)OC(F)(F)F)C(=O)C(CC1=O)S\\C(\\NC)=N\\c(ccc(c3C)C)c3",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound N1(c2ccc(cc2)OC(F)(F)F)C(=O)C(CC1=O)S\\C(\\NC)=N\\c(ccc(c3C)C)c3?",
    "answer":"No",
    "_id":55105
  },
  {
    "COADD_ID":"CO-ADD:0227218",
    "INHIB_AVE":-2.08,
    "SMILES":"C(=O)(C(c1ccccc1)c2ccccc2)NCC(=O)N\\N=C\/c(ccc(c3I)OC)c3",
    "HIT":0.0,
    "question":"Is C(=O)(C(c1ccccc1)c2ccccc2)NCC(=O)N\\N=C\/c(ccc(c3I)OC)c3 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":64594
  },
  {
    "COADD_ID":"CO-ADD:0257030",
    "INHIB_AVE":10.34,
    "SMILES":"N1(CSCC1C(=O)Nc2cccc(C)c2)C(=O)OCc3ccccc3",
    "HIT":0.0,
    "question":"Does treatment with N1(CSCC1C(=O)Nc2cccc(C)c2)C(=O)OCc3ccccc3 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":16155
  },
  {
    "COADD_ID":"CO-ADD:0136241",
    "INHIB_AVE":11.1,
    "SMILES":"n1c(SC)nc(c(c1)n2)n(C3C(O)C(O)C(CO)O3)c2",
    "HIT":0.0,
    "question":"Is n1c(SC)nc(c(c1)n2)n(C3C(O)C(O)C(CO)O3)c2 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":14296
  },
  {
    "COADD_ID":"CO-ADD:0237085",
    "INHIB_AVE":13.44,
    "SMILES":"CCCn1c(CNc2ccccc2O)nc3ccccc13",
    "HIT":0.0,
    "question":"Is CCCn1c(CNc2ccccc2O)nc3ccccc13 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":9863
  },
  {
    "COADD_ID":"CO-ADD:0259686",
    "INHIB_AVE":-14.75,
    "SMILES":"C1(C(=O)N\\N=C\\c(cc2)ccc2N(C)C)C3CCCC1C3c4ccccc4",
    "HIT":0.0,
    "question":"Does the proposed molecule C1(C(=O)N\\N=C\\c(cc2)ccc2N(C)C)C3CCCC1C3c4ccccc4 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":81225
  },
  {
    "COADD_ID":"CO-ADD:0321508",
    "INHIB_AVE":-11.85,
    "SMILES":"C1(=O)Oc(c(cc(c2OC(OCCCC)=O)Br)S1)c2",
    "HIT":0.0,
    "question":"Is C1(=O)Oc(c(cc(c2OC(OCCCC)=O)Br)S1)c2 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":79941
  },
  {
    "COADD_ID":"CO-ADD:0249914",
    "INHIB_AVE":1.31,
    "SMILES":"c1(c[nH]nc1c2ccccc2)C3C4=C(CC(C)(C)CC4=O)OC(CC(C)(C)CC5=O)=C35",
    "HIT":0.0,
    "question":"Does c1(c[nH]nc1c2ccccc2)C3C4=C(CC(C)(C)CC4=O)OC(CC(C)(C)CC5=O)=C35 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":52123
  },
  {
    "COADD_ID":"CO-ADD:0229863",
    "INHIB_AVE":3.88,
    "SMILES":"N(C(C)(C)C#C)(C(C)C1)CC(C1(O)c2ccccc2)C",
    "HIT":0.0,
    "question":"Can exposure to N(C(C)(C)C#C)(C(C)C1)CC(C1(O)c2ccccc2)C lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":40696
  },
  {
    "COADD_ID":"CO-ADD:0296113",
    "INHIB_AVE":-0.4,
    "SMILES":"[N+](=O)([O-])c1ccc(cc1NC(C)C23C[C@]([H])(C[C@](C4)([H])C2)C[C@@]4([H])C3)N5CCCCC5",
    "HIT":0.0,
    "question":"Does treatment with [N+](=O)([O-])c1ccc(cc1NC(C)C23C[C@]([H])(C[C@](C4)([H])C2)C[C@@]4([H])C3)N5CCCCC5 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":58986
  },
  {
    "COADD_ID":"CO-ADD:0295262",
    "INHIB_AVE":-6.24,
    "SMILES":"C(C#N)(C1c2ccc(cc2)OCCC)=C(N)OC(CCCC3=O)=C13",
    "HIT":0.0,
    "question":"Can C(C#N)(C1c2ccc(cc2)OCCC)=C(N)OC(CCCC3=O)=C13 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":74148
  },
  {
    "COADD_ID":"CO-ADD:0258354",
    "INHIB_AVE":-2.75,
    "SMILES":"c1(SC)nccn1CC(=O)Nc2ccccc2",
    "HIT":0.0,
    "question":"Is c1(SC)nccn1CC(=O)Nc2ccccc2 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":66524
  },
  {
    "COADD_ID":"CO-ADD:0299886",
    "INHIB_AVE":2.5,
    "SMILES":"N(\\C(=C\\c1ccc(cc1Cl)Cl)\\C(O2)=O)=C2c3cccc(OC)c3",
    "HIT":0.0,
    "question":"Is N(\\C(=C\\c1ccc(cc1Cl)Cl)\\C(O2)=O)=C2c3cccc(OC)c3 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":46879
  },
  {
    "COADD_ID":"CO-ADD:0277785",
    "INHIB_AVE":7.31,
    "SMILES":"C(=O)(C(OCC)=O)N(c1ccccc1)NC(=O)C(O)(c2ccc(cc2)C)c3ccc(cc3)C",
    "HIT":0.0,
    "question":"Does C(=O)(C(OCC)=O)N(c1ccccc1)NC(=O)C(O)(c2ccc(cc2)C)c3ccc(cc3)C show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":25812
  },
  {
    "COADD_ID":"CO-ADD:0312086",
    "INHIB_AVE":12.33,
    "SMILES":"C12=C(C=C(C)NC1=O)\\C(\\OC2=O)=C\/c(cc3)ccc3NC(C)=O",
    "HIT":0.0,
    "question":"Is C12=C(C=C(C)NC1=O)\\C(\\OC2=O)=C\/c(cc3)ccc3NC(C)=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":11813
  },
  {
    "COADD_ID":"CO-ADD:0256979",
    "INHIB_AVE":-78.48,
    "SMILES":"C12=C(C(NC(c3ccccc3Cl)N1)=O)SC(=S)N2c4ccccc4",
    "HIT":0.0,
    "question":"Does treatment with C12=C(C(NC(c3ccccc3Cl)N1)=O)SC(=S)N2c4ccccc4 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":82703
  },
  {
    "COADD_ID":"CO-ADD:0259279",
    "INHIB_AVE":12.98,
    "SMILES":"S(=O)(=O)(c1ccc(cc1)F)N2CCC(CC2)C(OCC)=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound S(=O)(=O)(c1ccc(cc1)F)N2CCC(CC2)C(OCC)=O?",
    "answer":"No",
    "_id":10601
  },
  {
    "COADD_ID":"CO-ADD:0137229",
    "INHIB_AVE":4.04,
    "SMILES":"O=C(N([C@](O)(C[C@]1([C@@H](C)[C@@H]([C@]2(C)[C@H](CC(N3C)=O)OC(=O)[C@@](C)([H])N(C)C(C)=O)O2)[H])[C@H](OC)C=CC=C(\/C)Cc4cc3c(c(OC)c4)Cl)[H])O1",
    "HIT":0.0,
    "question":"Does O=C(N([C@](O)(C[C@]1([C@@H](C)[C@@H]([C@]2(C)[C@H](CC(N3C)=O)OC(=O)[C@@](C)([H])N(C)C(C)=O)O2)[H])[C@H](OC)C=CC=C(\/C)Cc4cc3c(c(OC)c4)Cl)[H])O1 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":40004
  },
  {
    "COADD_ID":"CO-ADD:0155784",
    "INHIB_AVE":3.64,
    "SMILES":"O=C(OC)C1=NNC=C1",
    "HIT":0.0,
    "question":"Is O=C(OC)C1=NNC=C1 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":41803
  },
  {
    "COADD_ID":"CO-ADD:0304018",
    "INHIB_AVE":-6.67,
    "SMILES":"N(\\C(=C\\c(cc1OC)cc(c1OC(c2ccccc2)=O)Cl)\\C(O3)=O)=C3c4ccc(cc4)Cl",
    "HIT":0.0,
    "question":"Can N(\\C(=C\\c(cc1OC)cc(c1OC(c2ccccc2)=O)Cl)\\C(O3)=O)=C3c4ccc(cc4)Cl act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":74834
  },
  {
    "COADD_ID":"CO-ADD:0258603",
    "INHIB_AVE":7.26,
    "SMILES":"N1(c2ccc(cc2)OC)C(=O)CC(N(CCc(ccc(c3OC)OC)c3)C(C)=O)C1=O",
    "HIT":0.0,
    "question":"Does the proposed molecule N1(c2ccc(cc2)OC)C(=O)CC(N(CCc(ccc(c3OC)OC)c3)C(C)=O)C1=O exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":25997
  },
  {
    "COADD_ID":"CO-ADD:0254426",
    "INHIB_AVE":-15.86,
    "SMILES":"S(=O)(=O)(c1ccc(c2c1)cccc2)Nc3ccccc3OC",
    "HIT":0.0,
    "question":"Can exposure to S(=O)(=O)(c1ccc(c2c1)cccc2)Nc3ccccc3OC lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":81528
  },
  {
    "COADD_ID":"CO-ADD:0295486",
    "INHIB_AVE":5.53,
    "SMILES":"C1(OC(C)=O)C(CCC(OC(C)=O)C1[N+](C)(C)C)[N+](C)(C)C.[I-].[I-]",
    "HIT":0.0,
    "question":"Can C1(OC(C)=O)C(CCC(OC(C)=O)C1[N+](C)(C)C)[N+](C)(C)C.[I-].[I-] act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":33297
  },
  {
    "COADD_ID":"CO-ADD:0285829",
    "INHIB_AVE":-10.52,
    "SMILES":"S(=O)(=O)(N(CC1)CCO1)c2cc(ccc2N(CC3)CCN3CCO)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound S(=O)(=O)(N(CC1)CCO1)c2cc(ccc2N(CC3)CCN3CCO)[N+](=O)[O-]?",
    "answer":"No",
    "_id":79096
  },
  {
    "COADD_ID":"CO-ADD:0258996",
    "INHIB_AVE":14.41,
    "SMILES":"[N+](=O)([O-])c1cccc(\\C=N\\N=C(\/SCC2=O)\\N2)c1O",
    "HIT":0.0,
    "question":"Does [N+](=O)([O-])c1cccc(\\C=N\\N=C(\/SCC2=O)\\N2)c1O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":8401
  },
  {
    "COADD_ID":"CO-ADD:0230249",
    "INHIB_AVE":-17.45,
    "SMILES":"N(=C\\c(ccc(c1OC)OC)c1)\/NC(CCCCCCC)=O",
    "HIT":0.0,
    "question":"Can N(=C\\c(ccc(c1OC)OC)c1)\/NC(CCCCCCC)=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":81817
  },
  {
    "COADD_ID":"CO-ADD:0292569",
    "INHIB_AVE":2.44,
    "SMILES":"n12c(cc(c3ccc(cc3)Cl)n1)nc(cc2C(F)(F)F)c4ccccc4",
    "HIT":0.0,
    "question":"Is n12c(cc(c3ccc(cc3)Cl)n1)nc(cc2C(F)(F)F)c4ccccc4 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":47140
  },
  {
    "COADD_ID":"CO-ADD:0244460",
    "INHIB_AVE":7.92,
    "SMILES":"C(NN)(=O)C(=O)Nc1cccc(Cl)c1",
    "HIT":0.0,
    "question":"Does C(NN)(=O)C(=O)Nc1cccc(Cl)c1 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":23489
  },
  {
    "COADD_ID":"CO-ADD:0247548",
    "INHIB_AVE":7.65,
    "SMILES":"c1(SCC(=O)Nc(cc2)ccc2C(C)=O)sc3c(ccc(c3)NC(=O)c(cc4)ccc4C(C)(C)C)n1",
    "HIT":0.0,
    "question":"Is c1(SCC(=O)Nc(cc2)ccc2C(C)=O)sc3c(ccc(c3)NC(=O)c(cc4)ccc4C(C)(C)C)n1 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":24498
  },
  {
    "COADD_ID":"CO-ADD:0136482",
    "INHIB_AVE":-6.88,
    "SMILES":"O=C1N([H])C2(CCCC2)SC(Nc3cccc(C)c3)=C1C#N",
    "HIT":0.0,
    "question":"Does O=C1N([H])C2(CCCC2)SC(Nc3cccc(C)c3)=C1C#N demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":75160
  },
  {
    "COADD_ID":"CO-ADD:0254092",
    "INHIB_AVE":10.25,
    "SMILES":"S(C)(=O)(=O)N(c1ccc(cc1)Cl)CC(=O)Nc(ccc(c2Cl)Cl)c2",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound S(C)(=O)(=O)N(c1ccc(cc1)Cl)CC(=O)Nc(ccc(c2Cl)Cl)c2?",
    "answer":"No",
    "_id":16351
  },
  {
    "COADD_ID":"CO-ADD:0135968",
    "INHIB_AVE":20.73,
    "SMILES":"S1C(C)(C)C(C(O)=O)N(C=O)C1(C)C",
    "HIT":0.0,
    "question":"Is S1C(C)(C)C(C(O)=O)N(C=O)C1(C)C effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":2468
  },
  {
    "COADD_ID":"CO-ADD:0299873",
    "INHIB_AVE":-0.13,
    "SMILES":"S1(=O)(=O)c(cccc2)c2C(N(CCOC(=O)C(CC(N3c4ccccc4)=O)C3)c5ccccc5OC)=N1",
    "HIT":0.0,
    "question":"Does the proposed molecule S1(=O)(=O)c(cccc2)c2C(N(CCOC(=O)C(CC(N3c4ccccc4)=O)C3)c5ccccc5OC)=N1 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":57966
  },
  {
    "COADD_ID":"CO-ADD:0254702",
    "INHIB_AVE":8.6,
    "SMILES":"N1(C2c3ccc(c(OC)c3)OC)C(S\\C(=C\\c4cc(I)cc(I)c4O)\\C1=O)=NC(C)=C2C(OCC)=O",
    "HIT":0.0,
    "question":"Can N1(C2c3ccc(c(OC)c3)OC)C(S\\C(=C\\c4cc(I)cc(I)c4O)\\C1=O)=NC(C)=C2C(OCC)=O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":21143
  },
  {
    "COADD_ID":"CO-ADD:0157136",
    "INHIB_AVE":10.9,
    "SMILES":"O=C(NC1=CC=CC(C)=C1)C(C2)(C3=CC=CC=C3)C2(Cl)Cl",
    "HIT":0.0,
    "question":"Does treatment with O=C(NC1=CC=CC(C)=C1)C(C2)(C3=CC=CC=C3)C2(Cl)Cl result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":14747
  },
  {
    "COADD_ID":"CO-ADD:0300950",
    "INHIB_AVE":6.85,
    "SMILES":"N1(c(cc2)ccc2C(C)(C)C)CC(CC1=O)C(=O)Nc3cccc(C)c3C",
    "HIT":0.0,
    "question":"Does N1(c(cc2)ccc2C(C)(C)C)CC(CC1=O)C(=O)Nc3cccc(C)c3C show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":27604
  },
  {
    "COADD_ID":"CO-ADD:0321207",
    "INHIB_AVE":-3.1,
    "SMILES":"c1([nH]c(c2n1)cccc2)S(=O)(=O)CCOc3ccccc3",
    "HIT":0.0,
    "question":"Can c1([nH]c(c2n1)cccc2)S(=O)(=O)CCOc3ccccc3 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":67509
  },
  {
    "COADD_ID":"CO-ADD:0323277",
    "INHIB_AVE":4.4,
    "SMILES":"n1(c2ccccc2)c(SCc(cc(OCO3)c3c4)c4Cl)nnc1c5cccc(F)c5",
    "HIT":0.0,
    "question":"Is n1(c2ccccc2)c(SCc(cc(OCO3)c3c4)c4Cl)nnc1c5cccc(F)c5 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":38346
  },
  {
    "COADD_ID":"CO-ADD:0164662",
    "INHIB_AVE":8.12,
    "SMILES":"COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO.Cl",
    "HIT":0.0,
    "question":"Is COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO.Cl capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":22776
  },
  {
    "COADD_ID":"CO-ADD:0231156",
    "INHIB_AVE":15.28,
    "SMILES":"C(N(CC)CC)(=S)Oc(cc1)ccc1C(=O)Nc2cccc(Br)c2",
    "HIT":0.0,
    "question":"Can C(N(CC)CC)(=S)Oc(cc1)ccc1C(=O)Nc2cccc(Br)c2 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":7215
  },
  {
    "COADD_ID":"CO-ADD:0319607",
    "INHIB_AVE":4.25,
    "SMILES":"c1(cc(ccc1NC(CC2(C)C)CC(N2)(C)C)C(F)(F)F)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Does c1(cc(ccc1NC(CC2(C)C)CC(N2)(C)C)C(F)(F)F)[N+](=O)[O-] demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":39021
  },
  {
    "COADD_ID":"CO-ADD:0312574",
    "INHIB_AVE":-11.97,
    "SMILES":"C1=C[C@]2(O[C@H]13)[C@]([C@@]34[H])([H])[C@@]5(O[C@H]4C6C5C(N(C6=O)C)=O)CSC2",
    "HIT":0.0,
    "question":"Can exposure to C1=C[C@]2(O[C@H]13)[C@]([C@@]34[H])([H])[C@@]5(O[C@H]4C6C5C(N(C6=O)C)=O)CSC2 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":80008
  },
  {
    "COADD_ID":"CO-ADD:0163550",
    "INHIB_AVE":0.33,
    "SMILES":"N1(c2cccc(cccc3)c23)C(=O)C(C4C1=O)C(c5ccccc5)(C(C46c7ccccc7)=O)C(=C6c8ccccc8)c9ccccc9",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound N1(c2cccc(cccc3)c23)C(=O)C(C4C1=O)C(c5ccccc5)(C(C46c7ccccc7)=O)C(=C6c8ccccc8)c9ccccc9?",
    "answer":"No",
    "_id":56138
  },
  {
    "COADD_ID":"CO-ADD:0293779",
    "INHIB_AVE":-4.28,
    "SMILES":"n(\\N=C\\c1cccc(OCCOc2ccccc2)c1)(cnn3)c3",
    "HIT":0.0,
    "question":"Does treatment with n(\\N=C\\c1cccc(OCCOc2ccccc2)c1)(cnn3)c3 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":70368
  },
  {
    "COADD_ID":"CO-ADD:0326342",
    "INHIB_AVE":-0.22,
    "SMILES":"c1(NC(=O)C(C(F)(F)F)C(F)(F)F)sc(c2c1C#N)CCC2",
    "HIT":0.0,
    "question":"Does c1(NC(=O)C(C(F)(F)F)C(F)(F)F)sc(c2c1C#N)CCC2 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":58328
  },
  {
    "COADD_ID":"CO-ADD:0231448",
    "INHIB_AVE":8.36,
    "SMILES":"N(=C\\c(c(O)ccc1C(O)=O)c1)\/c2c(C)cccc2O",
    "HIT":0.0,
    "question":"Does treatment with N(=C\\c(c(O)ccc1C(O)=O)c1)\/c2c(C)cccc2O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":21929
  },
  {
    "COADD_ID":"CO-ADD:0305003",
    "INHIB_AVE":3.29,
    "SMILES":"N1[C@@H](c2ccccc2Br)[C@@]([H])(CC=C3)[C@@]3(c4c1c(OC)ccc4Cl)[H]",
    "HIT":0.0,
    "question":"Can exposure to N1[C@@H](c2ccccc2Br)[C@@]([H])(CC=C3)[C@@]3(c4c1c(OC)ccc4Cl)[H] lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":43315
  },
  {
    "COADD_ID":"CO-ADD:0228366",
    "INHIB_AVE":-0.82,
    "SMILES":"n1c2c(oc1c3cccc(I)c3)ccc(c2)\\N=C\\c4cccc(Cl)c4",
    "HIT":0.0,
    "question":"Does the proposed molecule n1c2c(oc1c3cccc(I)c3)ccc(c2)\\N=C\\c4cccc(Cl)c4 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":60491
  },
  {
    "COADD_ID":"CO-ADD:0311115",
    "INHIB_AVE":4.28,
    "SMILES":"S(=O)(=O)(NC1CCCCC1)c(ccc(c2s3)nc3SC)c2",
    "HIT":0.0,
    "question":"Does treatment with S(=O)(=O)(NC1CCCCC1)c(ccc(c2s3)nc3SC)c2 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":38899
  },
  {
    "COADD_ID":"CO-ADD:0230184",
    "INHIB_AVE":-16.51,
    "SMILES":"[N+](=O)([O-])c1ccc(cc1)CC(=O)N\\N=C\\C=C\\c(cc2)ccc2N(C)C",
    "HIT":0.0,
    "question":"Is [N+](=O)([O-])c1ccc(cc1)CC(=O)N\\N=C\\C=C\\c(cc2)ccc2N(C)C effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":81645
  },
  {
    "COADD_ID":"CO-ADD:0246197",
    "INHIB_AVE":4.92,
    "SMILES":"C(=C\/NNC(=O)c(cccc1[N+](=O)[O-])c1)(\/c2cccc(Br)c2)\\C(OC)=O",
    "HIT":0.0,
    "question":"Is C(=C\/NNC(=O)c(cccc1[N+](=O)[O-])c1)(\/c2cccc(Br)c2)\\C(OC)=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":35970
  },
  {
    "COADD_ID":"CO-ADD:0218331",
    "INHIB_AVE":13.6,
    "SMILES":"[N+](=O)([O-])c1ccc(cc1)\\C=N\\NC(=O)c2ccccc2O",
    "HIT":0.0,
    "question":"Is [N+](=O)([O-])c1ccc(cc1)\\C=N\\NC(=O)c2ccccc2O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":9620
  },
  {
    "COADD_ID":"CO-ADD:0331151",
    "INHIB_AVE":-0.33,
    "SMILES":"n1(C(CCC(O)=O)=O)c2c(nc1CC)cccc2",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound n1(C(CCC(O)=O)=O)c2c(nc1CC)cccc2?",
    "answer":"No",
    "_id":58737
  },
  {
    "COADD_ID":"CO-ADD:0155329",
    "INHIB_AVE":8.03,
    "SMILES":"NC1=NON=C1C2=NN=C(N)S2",
    "HIT":0.0,
    "question":"Can NC1=NON=C1C2=NN=C(N)S2 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":23072
  },
  {
    "COADD_ID":"CO-ADD:0156387",
    "INHIB_AVE":3.65,
    "SMILES":"[O-][N+](C1=CC=CC=C1NCCNC(C(C(Cl)=C2)=CC(F)=C2F)=O)=O",
    "HIT":0.0,
    "question":"Is [O-][N+](C1=CC=CC=C1NCCNC(C(C(Cl)=C2)=CC(F)=C2F)=O)=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":41725
  },
  {
    "COADD_ID":"CO-ADD:0220754",
    "INHIB_AVE":5.08,
    "SMILES":"[N+](=O)([O-])c(cc1)ccc1C(=O)Oc2ccccc2\\C=N\\NC(COc(cc3)ccc3OC)=O",
    "HIT":0.0,
    "question":"Does [N+](=O)([O-])c(cc1)ccc1C(=O)Oc2ccccc2\\C=N\\NC(COc(cc3)ccc3OC)=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":35284
  },
  {
    "COADD_ID":"CO-ADD:0228498",
    "INHIB_AVE":5.87,
    "SMILES":"C12(c3c(NC1=O)ccc(Br)c3)C(C#N)=C(N)OC(C)=C2C(=O)OC(C)(C)C",
    "HIT":0.0,
    "question":"Does treatment with C12(c3c(NC1=O)ccc(Br)c3)C(C#N)=C(N)OC(C)=C2C(=O)OC(C)(C)C result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":31809
  },
  {
    "COADD_ID":"CO-ADD:0285312",
    "INHIB_AVE":-0.13,
    "SMILES":"N1(C(=O)c2cccc(Cl)c2)N=C(C3C1(O)C(F)(F)F)CCCCC3",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound N1(C(=O)c2cccc(Cl)c2)N=C(C3C1(O)C(F)(F)F)CCCCC3?",
    "answer":"No",
    "_id":57958
  },
  {
    "COADD_ID":"CO-ADD:0235438",
    "INHIB_AVE":15.01,
    "SMILES":"n1(\\N=C\\c2ccccc2)c3c(c(cccc4)c14)cccc3",
    "HIT":0.0,
    "question":"Does n1(\\N=C\\c2ccccc2)c3c(c(cccc4)c14)cccc3 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":7593
  },
  {
    "COADD_ID":"CO-ADD:0307050",
    "INHIB_AVE":5.42,
    "SMILES":"[N+](=O)([O-])c(cc1)cc(c1N(CC2)CCN2C(=O)c3ccc(cc3)Br)F",
    "HIT":0.0,
    "question":"Does [N+](=O)([O-])c(cc1)cc(c1N(CC2)CCN2C(=O)c3ccc(cc3)Br)F demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":33827
  },
  {
    "COADD_ID":"CO-ADD:0256790",
    "INHIB_AVE":-2.5,
    "SMILES":"[N+](=O)([O-])c1c(ccc(c1)C(F)(F)F)SCC(=O)Nc(cc2)ccc2Cl",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound [N+](=O)([O-])c1c(ccc(c1)C(F)(F)F)SCC(=O)Nc(cc2)ccc2Cl?",
    "answer":"No",
    "_id":65808
  },
  {
    "COADD_ID":"CO-ADD:0217113",
    "INHIB_AVE":8.18,
    "SMILES":"c1(c(CCN(C)C1)nc(c2C#N)SCC(=O)OC(C)(C)C)c2c3cccs3",
    "HIT":0.0,
    "question":"Is c1(c(CCN(C)C1)nc(c2C#N)SCC(=O)OC(C)(C)C)c2c3cccs3 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":22549
  },
  {
    "COADD_ID":"CO-ADD:0293835",
    "INHIB_AVE":-4.22,
    "SMILES":"C12=C(COC1=O)Nc(c3SC2c4ccc(cc4)F)cccc3",
    "HIT":0.0,
    "question":"Does the proposed molecule C12=C(COC1=O)Nc(c3SC2c4ccc(cc4)F)cccc3 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":70254
  },
  {
    "COADD_ID":"CO-ADD:0284538",
    "INHIB_AVE":-4.05,
    "SMILES":"C1(=Cc2c(OC1=O)ccc(Br)c2)C(=O)NC(=S)NNC(COc(cc3)ccc3Cl)=O",
    "HIT":0.0,
    "question":"Can C1(=Cc2c(OC1=O)ccc(Br)c2)C(=O)NC(=S)NNC(COc(cc3)ccc3Cl)=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":69867
  },
  {
    "COADD_ID":"CO-ADD:0258968",
    "INHIB_AVE":10.02,
    "SMILES":"C12=C(CC(C)(C)CC1=O)c3c(ccc(cccc4)c34)NC2c(cc(cc5[N+](=O)[O-])[N+](=O)[O-])c5O",
    "HIT":0.0,
    "question":"Can C12=C(CC(C)(C)CC1=O)c3c(ccc(cccc4)c34)NC2c(cc(cc5[N+](=O)[O-])[N+](=O)[O-])c5O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":16937
  },
  {
    "COADD_ID":"CO-ADD:0293575",
    "INHIB_AVE":13.42,
    "SMILES":"[N+](=O)([O-])c(cc1)ccc1N(CC2)CCN2CCC(=O)Nc(cc3)ccc3C",
    "HIT":0.0,
    "question":"Can [N+](=O)([O-])c(cc1)ccc1N(CC2)CCN2CCC(=O)Nc(cc3)ccc3C act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":9903
  },
  {
    "COADD_ID":"CO-ADD:0331358",
    "INHIB_AVE":-1.21,
    "SMILES":"N1(c(c(cc(c2)OCC)C(=C34)C(SS3)=S)c2C(=O)C1=O)C4(C)C",
    "HIT":0.0,
    "question":"Is N1(c(c(cc(c2)OCC)C(=C34)C(SS3)=S)c2C(=O)C1=O)C4(C)C effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":61782
  },
  {
    "COADD_ID":"CO-ADD:0227297",
    "INHIB_AVE":4.99,
    "SMILES":"[N+](=O)([O-])c1ccc(cc1\\C=N\\NC(COc2cccc(C)c2)=O)O",
    "HIT":0.0,
    "question":"Does [N+](=O)([O-])c1ccc(cc1\\C=N\\NC(COc2cccc(C)c2)=O)O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":35689
  },
  {
    "COADD_ID":"CO-ADD:0331502",
    "INHIB_AVE":15.51,
    "SMILES":"C1(C(=O)NC(N2c3ccccc3)=O)=C2NC(=O)C1(NC(Cc4ccccc4)=O)C(F)(F)F",
    "HIT":0.0,
    "question":"Can exposure to C1(C(=O)NC(N2c3ccccc3)=O)=C2NC(=O)C1(NC(Cc4ccccc4)=O)C(F)(F)F lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":6934
  },
  {
    "COADD_ID":"CO-ADD:0158022",
    "INHIB_AVE":6.57,
    "SMILES":"O=S(N=C1NCCOC)(C2=C1C=CC([N+]([O-])=O)=C2)=O",
    "HIT":0.0,
    "question":"Does O=S(N=C1NCCOC)(C2=C1C=CC([N+]([O-])=O)=C2)=O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":28827
  },
  {
    "COADD_ID":"CO-ADD:0257767",
    "INHIB_AVE":5.68,
    "SMILES":"C(=N\/c(cc1)ccc1C)(\/S\\C(\\C2=O)=C\\c(ccc(c3OCC)OCc4ccccc4)c3)\\N2",
    "HIT":0.0,
    "question":"Is C(=N\/c(cc1)ccc1C)(\/S\\C(\\C2=O)=C\\c(ccc(c3OCC)OCc4ccccc4)c3)\\N2 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":32601
  },
  {
    "COADD_ID":"CO-ADD:0254338",
    "INHIB_AVE":-2.74,
    "SMILES":"C(=O)(N\\N=C\/c(cc1)ccc1OCc2ccccc2Cl)c(ccc(c34)OCO3)c4",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C(=O)(N\\N=C\/c(cc1)ccc1OCc2ccccc2Cl)c(ccc(c34)OCO3)c4?",
    "answer":"No",
    "_id":66497
  },
  {
    "COADD_ID":"CO-ADD:0236470",
    "INHIB_AVE":1.39,
    "SMILES":"N1(CN(C)[N+](=O)[O-])c(ccc(c2)[N+](=O)[O-])c2C(=O)C1=O",
    "HIT":0.0,
    "question":"Does N1(CN(C)[N+](=O)[O-])c(ccc(c2)[N+](=O)[O-])c2C(=O)C1=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":51778
  },
  {
    "COADD_ID":"CO-ADD:0291380",
    "INHIB_AVE":6.04,
    "SMILES":"c1(C#N)c(cccc2)c2n(C)c1CNc(cc3)ccc3C",
    "HIT":0.0,
    "question":"Can c1(C#N)c(cccc2)c2n(C)c1CNc(cc3)ccc3C effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":31098
  },
  {
    "COADD_ID":"CO-ADD:0227259",
    "INHIB_AVE":3.05,
    "SMILES":"CC(C)([C@@H](C1)C2)[C@@H]2[C@H](CO)[C@H]1S(O)\\N=C\\c(ccc([N+](=O)[O-])c3)c3",
    "HIT":0.0,
    "question":"Can exposure to CC(C)([C@@H](C1)C2)[C@@H]2[C@H](CO)[C@H]1S(O)\\N=C\\c(ccc([N+](=O)[O-])c3)c3 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":44433
  },
  {
    "COADD_ID":"CO-ADD:0242307",
    "INHIB_AVE":25.06,
    "SMILES":"c1([nH]c(c2n1)cccc2)\\C(\\C#N)=C\\c3cccc(Br)c3",
    "HIT":0.0,
    "question":"Does treatment with c1([nH]c(c2n1)cccc2)\\C(\\C#N)=C\\c3cccc(Br)c3 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":1166
  },
  {
    "COADD_ID":"CO-ADD:0311159",
    "INHIB_AVE":-11.65,
    "SMILES":"c1(NC(=O)c2c(Cl)ccc(c2)[N+](=O)[O-])sc(c3c1C#N)CCC3",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(NC(=O)c2c(Cl)ccc(c2)[N+](=O)[O-])sc(c3c1C#N)CCC3?",
    "answer":"No",
    "_id":79813
  },
  {
    "COADD_ID":"CO-ADD:0286355",
    "INHIB_AVE":0.66,
    "SMILES":"c1(SCC(O)=O)nc(C)ccc1C#N",
    "HIT":0.0,
    "question":"Can c1(SCC(O)=O)nc(C)ccc1C#N effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":54860
  },
  {
    "COADD_ID":"CO-ADD:0332230",
    "INHIB_AVE":7.05,
    "SMILES":"C1(C(OC)=O)=C(C)NC(NC1c2cc(OC)c(cc2Br)OC)=O",
    "HIT":0.0,
    "question":"Is C1(C(OC)=O)=C(C)NC(NC1c2cc(OC)c(cc2Br)OC)=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":26769
  },
  {
    "COADD_ID":"CO-ADD:0234511",
    "INHIB_AVE":1.4,
    "SMILES":"C12=C(CC(C)(C)CC1=O)c3c(ccc(cccc4)c34)NC2c(c5)c(N6CCCCC6)cc(N7CCCCC7)c5[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Is C12=C(CC(C)(C)CC1=O)c3c(ccc(cccc4)c34)NC2c(c5)c(N6CCCCC6)cc(N7CCCCC7)c5[N+](=O)[O-] capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":51729
  },
  {
    "COADD_ID":"CO-ADD:0218711",
    "INHIB_AVE":1.73,
    "SMILES":"C(=O)(N\\N=C\\c(cc1)ccc1I)C(=O)Nc2ccccc2C",
    "HIT":0.0,
    "question":"Does the proposed molecule C(=O)(N\\N=C\\c(cc1)ccc1I)C(=O)Nc2ccccc2C exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":50301
  },
  {
    "COADD_ID":"CO-ADD:0235687",
    "INHIB_AVE":13.42,
    "SMILES":"C1(C(=O)Nc(ccc(Br)c2)c12)(N(C3)C4)N(CC4(C5=O)C)CC35C",
    "HIT":0.0,
    "question":"Does treatment with C1(C(=O)Nc(ccc(Br)c2)c12)(N(C3)C4)N(CC4(C5=O)C)CC35C result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":9885
  },
  {
    "COADD_ID":"CO-ADD:0258360",
    "INHIB_AVE":2.59,
    "SMILES":"c1(SCC(=O)Nc(cc2)ccc2CC)sc3c(ccc(c3)NC(=O)\\C=C\/c4ccccc4)n1",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(SCC(=O)Nc(cc2)ccc2CC)sc3c(ccc(c3)NC(=O)\\C=C\/c4ccccc4)n1?",
    "answer":"No",
    "_id":46465
  },
  {
    "COADD_ID":"CO-ADD:0283491",
    "INHIB_AVE":-4.18,
    "SMILES":"N1C(C)(C)CC(CC1(C)C)CCO",
    "HIT":0.0,
    "question":"Is N1C(C)(C)CC(CC1(C)C)CCO effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":70170
  },
  {
    "COADD_ID":"CO-ADD:0294318",
    "INHIB_AVE":3.4,
    "SMILES":"C12=C(CC(C)(C)CC1=O)Nc(c3NC2c(ccc4[N+](=O)[O-])o4)cc(c(C)c3)C",
    "HIT":0.0,
    "question":"Does C12=C(CC(C)(C)CC1=O)Nc(c3NC2c(ccc4[N+](=O)[O-])o4)cc(c(C)c3)C demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":42808
  },
  {
    "COADD_ID":"CO-ADD:0323499",
    "INHIB_AVE":12.49,
    "SMILES":"[s+]1c(SCC(O)=O)c(sc1N2CCCCC2)C.[I-]",
    "HIT":0.0,
    "question":"Is [s+]1c(SCC(O)=O)c(sc1N2CCCCC2)C.[I-] capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":11482
  },
  {
    "COADD_ID":"CO-ADD:0234188",
    "INHIB_AVE":3.82,
    "SMILES":"C(=C\\c(ccc(c12)OCO1)c2)(\/NC(c3ccccc3)=O)\\C(=O)N\\N=C\\c(cc4)ccc4OC(=O)c5cccc(Br)c5",
    "HIT":0.0,
    "question":"Does C(=C\\c(ccc(c12)OCO1)c2)(\/NC(c3ccccc3)=O)\\C(=O)N\\N=C\\c(cc4)ccc4OC(=O)c5cccc(Br)c5 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":41017
  },
  {
    "COADD_ID":"CO-ADD:0292912",
    "INHIB_AVE":-2.84,
    "SMILES":"c1(nc(c2ccc(cc2)OC)cc3C(F)(F)F)n3nc(C(=O)Nc(cc(Oc(cc4)ccc4Br)cc5[N+](=O)[O-])c5)c1Cl",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(nc(c2ccc(cc2)OC)cc3C(F)(F)F)n3nc(C(=O)Nc(cc(Oc(cc4)ccc4Br)cc5[N+](=O)[O-])c5)c1Cl?",
    "answer":"No",
    "_id":66799
  },
  {
    "COADD_ID":"CO-ADD:0158595",
    "INHIB_AVE":-5.37,
    "SMILES":"O=S(N1CCOCC1)(C2=CC=C(C(C(NC3=CC=C(I)C=C3)=O)=C2)Cl)=O",
    "HIT":0.0,
    "question":"Can exposure to O=S(N1CCOCC1)(C2=CC=C(C(C(NC3=CC=C(I)C=C3)=O)=C2)Cl)=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":72596
  },
  {
    "COADD_ID":"CO-ADD:0161272",
    "INHIB_AVE":0.24,
    "SMILES":"c1(cc(CCC2)c2n3)c3sc(c(c(C#N)c(N)n4)c5ccc(cc5)Br)c14",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(cc(CCC2)c2n3)c3sc(c(c(C#N)c(N)n4)c5ccc(cc5)Br)c14?",
    "answer":"No",
    "_id":56503
  },
  {
    "COADD_ID":"CO-ADD:0283046",
    "INHIB_AVE":16.75,
    "SMILES":"C(c1ccc(c(OC)c1)OC)(NC(=O)\\C=C\\c2ccccc2)NC(=O)\\C=C\\c3ccccc3",
    "HIT":0.0,
    "question":"Does treatment with C(c1ccc(c(OC)c1)OC)(NC(=O)\\C=C\\c2ccccc2)NC(=O)\\C=C\\c3ccccc3 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":5537
  },
  {
    "COADD_ID":"CO-ADD:0294542",
    "INHIB_AVE":1.88,
    "SMILES":"n1(c(c2ccccc2)c(n3)c(cc4)ccc4c5ccccc5)c3nc(c6ccccc6)c(c7ccccc7)n1",
    "HIT":0.0,
    "question":"Does treatment with n1(c(c2ccccc2)c(n3)c(cc4)ccc4c5ccccc5)c3nc(c6ccccc6)c(c7ccccc7)n1 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":49653
  },
  {
    "COADD_ID":"CO-ADD:0306748",
    "INHIB_AVE":-11.78,
    "SMILES":"C(C(OC)=O)(=CN(Cc1cccs1)C=C2C(OC)=O)C2c3cccc(OC)c3OC",
    "HIT":0.0,
    "question":"Is C(C(OC)=O)(=CN(Cc1cccs1)C=C2C(OC)=O)C2c3cccc(OC)c3OC effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":79896
  },
  {
    "COADD_ID":"CO-ADD:0223622",
    "INHIB_AVE":2.76,
    "SMILES":"N(=C\\c(ccc(c1OC)OCCC)c1)\/c2ccc(cc2C)C",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound N(=C\\c(ccc(c1OC)OCCC)c1)\/c2ccc(cc2C)C?",
    "answer":"No",
    "_id":45732
  },
  {
    "COADD_ID":"CO-ADD:0287447",
    "INHIB_AVE":-0.41,
    "SMILES":"N1(c(cc2)ccc2C(OCC)=O)C(=O)CC(N(CC3)CCN3c4ccc(cc4)Cl)C1=O",
    "HIT":0.0,
    "question":"Does N1(c(cc2)ccc2C(OCC)=O)C(=O)CC(N(CC3)CCN3c4ccc(cc4)Cl)C1=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":59045
  },
  {
    "COADD_ID":"CO-ADD:0220565",
    "INHIB_AVE":3.11,
    "SMILES":"c1(c2ccc(cc2)Cl)ccc(\\C=N\\NC(CNc3ccccc3C)=O)o1",
    "HIT":0.0,
    "question":"Does c1(c2ccc(cc2)Cl)ccc(\\C=N\\NC(CNc3ccccc3C)=O)o1 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":44109
  },
  {
    "COADD_ID":"CO-ADD:0295168",
    "INHIB_AVE":-10.01,
    "SMILES":"c1(cnn(C)c1C(OC)=O)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Does c1(cnn(C)c1C(OC)=O)[N+](=O)[O-] demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":78712
  },
  {
    "COADD_ID":"CO-ADD:0253838",
    "INHIB_AVE":-2.49,
    "SMILES":"S(=O)(=O)(c1ccc(cc1)C)N(Cc2ccccc2)c3ccccc3C(=O)N\\N=C\\c4ccccn4",
    "HIT":0.0,
    "question":"Does S(=O)(=O)(c1ccc(cc1)C)N(Cc2ccccc2)c3ccccc3C(=O)N\\N=C\\c4ccccn4 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":65789
  },
  {
    "COADD_ID":"CO-ADD:0304410",
    "INHIB_AVE":5.38,
    "SMILES":"C1(C)(C)Oc(c2O1)ccc(c2)NC(Cc(cc3)ccc3F)=O",
    "HIT":0.0,
    "question":"Does C1(C)(C)Oc(c2O1)ccc(c2)NC(Cc(cc3)ccc3F)=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":33971
  },
  {
    "COADD_ID":"CO-ADD:0286832",
    "INHIB_AVE":-8.58,
    "SMILES":"C1(C(=O)Nc2cccc(Br)c2)C3C1C(CC34)CC4",
    "HIT":0.0,
    "question":"Does C1(C(=O)Nc2cccc(Br)c2)C3C1C(CC34)CC4 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":77390
  },
  {
    "COADD_ID":"CO-ADD:0234943",
    "INHIB_AVE":1.38,
    "SMILES":"c1(cc(cc(OC)c1OCC(=O)N\\N=C\\c(c2c([nH]3)cccc2)c3)[N+](=O)[O-])[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Does c1(cc(cc(OC)c1OCC(=O)N\\N=C\\c(c2c([nH]3)cccc2)c3)[N+](=O)[O-])[N+](=O)[O-] demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":51824
  },
  {
    "COADD_ID":"CO-ADD:0326664",
    "INHIB_AVE":-1.75,
    "SMILES":"n1(c2c(C)cccc2C)nnnc1C3(CCCCC3)NCCc(c4c([nH]5)cccc4)c5C",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound n1(c2c(C)cccc2C)nnnc1C3(CCCCC3)NCCc(c4c([nH]5)cccc4)c5C?",
    "answer":"No",
    "_id":63572
  },
  {
    "COADD_ID":"CO-ADD:0258695",
    "INHIB_AVE":5.76,
    "SMILES":"c1(SCC(=O)Nc2c(C)cc(cc2C)C)sc3c(ccc(c3)NC(C)=O)n1",
    "HIT":0.0,
    "question":"Is c1(SCC(=O)Nc2c(C)cc(cc2C)C)sc3c(ccc(c3)NC(C)=O)n1 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":32296
  },
  {
    "COADD_ID":"CO-ADD:0292009",
    "INHIB_AVE":6.49,
    "SMILES":"n1(c2ccc(cc2)F)c(C)c(cc1C)\\C=N\/OCc3ccccc3",
    "HIT":0.0,
    "question":"Does treatment with n1(c2ccc(cc2)F)c(C)c(cc1C)\\C=N\/OCc3ccccc3 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":29157
  },
  {
    "COADD_ID":"CO-ADD:0149578",
    "INHIB_AVE":4.94,
    "SMILES":"C#CCN(CC1=CC2=CC(OCCCCC3CCN(CC4=CC=CC=C4)CC3)=CC=C2N1C)C",
    "HIT":0.0,
    "question":"Is C#CCN(CC1=CC2=CC(OCCCCC3CCN(CC4=CC=CC=C4)CC3)=CC=C2N1C)C effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":35905
  },
  {
    "COADD_ID":"CO-ADD:0160637",
    "INHIB_AVE":-0.86,
    "SMILES":"O=C1C(CCC1)C(C(C=C2)=CC=C2F)NC(C=C3)=CC=C3C",
    "HIT":0.0,
    "question":"Is O=C1C(CCC1)C(C(C=C2)=CC=C2F)NC(C=C3)=CC=C3C effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":60650
  },
  {
    "COADD_ID":"CO-ADD:0231059",
    "INHIB_AVE":10.09,
    "SMILES":"[N+](=O)([O-])c1ccc(cc1)CC(=O)Oc2ccccc2",
    "HIT":0.0,
    "question":"Is [N+](=O)([O-])c1ccc(cc1)CC(=O)Oc2ccccc2 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":16757
  },
  {
    "COADD_ID":"CO-ADD:0254936",
    "INHIB_AVE":8.69,
    "SMILES":"N1(c(cc2)ccc2[N+](=O)[O-])C(=O)\\C(\\C(C)=N1)=C\\NCCN(CC3)CCN3C(=O)C45CC(CC6C4)CC(C6)C5",
    "HIT":0.0,
    "question":"Does the proposed molecule N1(c(cc2)ccc2[N+](=O)[O-])C(=O)\\C(\\C(C)=N1)=C\\NCCN(CC3)CCN3C(=O)C45CC(CC6C4)CC(C6)C5 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":20877
  },
  {
    "COADD_ID":"CO-ADD:0161192",
    "INHIB_AVE":0.21,
    "SMILES":"C(=O)(c1ccc(cc1)Br)Nc2ccc(cn2)Cl",
    "HIT":0.0,
    "question":"Does C(=O)(c1ccc(cc1)Br)Nc2ccc(cn2)Cl demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":56620
  },
  {
    "COADD_ID":"CO-ADD:0324880",
    "INHIB_AVE":1.02,
    "SMILES":"N12C(SC(C(C)C)=N1)=NC(=O)\\C(=C\/c(c(OCCOc3cccc(C)c3)ccc4[N+](=O)[O-])c4)\\C2=N",
    "HIT":0.0,
    "question":"Does N12C(SC(C(C)C)=N1)=NC(=O)\\C(=C\/c(c(OCCOc3cccc(C)c3)ccc4[N+](=O)[O-])c4)\\C2=N show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":53372
  },
  {
    "COADD_ID":"CO-ADD:0278006",
    "INHIB_AVE":5.72,
    "SMILES":"c1(SCc(cc2)ccc2Br)sc3c(ccc(c3)\\N=C\\c(cc4Br)cc(c4O)Br)n1",
    "HIT":0.0,
    "question":"Can c1(SCc(cc2)ccc2Br)sc3c(ccc(c3)\\N=C\\c(cc4Br)cc(c4O)Br)n1 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":32443
  },
  {
    "COADD_ID":"CO-ADD:0157878",
    "INHIB_AVE":14.61,
    "SMILES":"N(N=C1)(C2=CC=CC=C2)C3=C1C(NCCC4=CC=CC=C4)=NC=N3",
    "HIT":0.0,
    "question":"Is N(N=C1)(C2=CC=CC=C2)C3=C1C(NCCC4=CC=CC=C4)=NC=N3 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":8114
  },
  {
    "COADD_ID":"CO-ADD:0149070",
    "INHIB_AVE":0.17,
    "SMILES":"c1cc(c(nc2c(c(n3)NC(=O)c4ccncc4)no3)cc1)n2Cc5ccncc5",
    "HIT":0.0,
    "question":"Can c1cc(c(nc2c(c(n3)NC(=O)c4ccncc4)no3)cc1)n2Cc5ccncc5 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":56802
  },
  {
    "COADD_ID":"CO-ADD:0247646",
    "INHIB_AVE":2.61,
    "SMILES":"P(=O)(N1CCCCC1)(N2CCCCC2)C(Cl)(Cl)CC3CCCCC3",
    "HIT":0.0,
    "question":"Does the proposed molecule P(=O)(N1CCCCC1)(N2CCCCC2)C(Cl)(Cl)CC3CCCCC3 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":46375
  },
  {
    "COADD_ID":"CO-ADD:0136431",
    "INHIB_AVE":11.22,
    "SMILES":"c1c(NC(=N)C(Nc(ccc(N)c2)c2)=N)ccc(N)c1",
    "HIT":0.0,
    "question":"Is c1c(NC(=N)C(Nc(ccc(N)c2)c2)=N)ccc(N)c1 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":14054
  },
  {
    "COADD_ID":"CO-ADD:0231342",
    "INHIB_AVE":6.29,
    "SMILES":"C(=O)(N\\N=C\\c(cc1)ccc1OCc2ccccc2Cl)CCSc(cc3)ccc3Cl",
    "HIT":0.0,
    "question":"Is C(=O)(N\\N=C\\c(cc1)ccc1OCc2ccccc2Cl)CCSc(cc3)ccc3Cl capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":30057
  },
  {
    "COADD_ID":"CO-ADD:0247536",
    "INHIB_AVE":-2.17,
    "SMILES":"n1(Cc2ccccc2)c(cccc3)c3c(SC)c1CC(=O)Nc(cc4)ccc4Cl",
    "HIT":0.0,
    "question":"Does the proposed molecule n1(Cc2ccccc2)c(cccc3)c3c(SC)c1CC(=O)Nc(cc4)ccc4Cl exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":64868
  },
  {
    "COADD_ID":"CO-ADD:0285405",
    "INHIB_AVE":-6.26,
    "SMILES":"C(C(=O)c1ccc(cc1)Br)(C2c3ccccc3F)=C(O)C(N2CCO)=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C(C(=O)c1ccc(cc1)Br)(C2c3ccccc3F)=C(O)C(N2CCO)=O?",
    "answer":"No",
    "_id":74195
  },
  {
    "COADD_ID":"CO-ADD:0157601",
    "INHIB_AVE":16.2,
    "SMILES":"C1(SC2=CC=C(\/C=N\/C3=CC=C(C=C3)C4=CC=CC=C4)O2)=NC(C=CC=C5)=C5N1",
    "HIT":0.0,
    "question":"Is C1(SC2=CC=C(\/C=N\/C3=CC=C(C=C3)C4=CC=CC=C4)O2)=NC(C=CC=C5)=C5N1 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":6130
  },
  {
    "COADD_ID":"CO-ADD:0319746",
    "INHIB_AVE":5.41,
    "SMILES":"c12c(C(N(C)C(=O)N1C)=O)n(c(SCC(=O)Nc(cc3)ccc3OC(F)(F)F)n2)Cc4ccccc4F",
    "HIT":0.0,
    "question":"Does the proposed molecule c12c(C(N(C)C(=O)N1C)=O)n(c(SCC(=O)Nc(cc3)ccc3OC(F)(F)F)n2)Cc4ccccc4F exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":33853
  },
  {
    "COADD_ID":"CO-ADD:0153070",
    "INHIB_AVE":-3.8,
    "SMILES":"O=C(C1=C(C(C)C)SC(N)=N1)NC2=CN(C)C(C(NCCN3CCOCC3)=O)=C2.OC(C(F)(F)F)=O",
    "HIT":0.0,
    "question":"Can O=C(C1=C(C(C)C)SC(N)=N1)NC2=CN(C)C(C(NCCN3CCOCC3)=O)=C2.OC(C(F)(F)F)=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":69271
  },
  {
    "COADD_ID":"CO-ADD:0277561",
    "INHIB_AVE":16.75,
    "SMILES":"N1(Cc2ccccc2)\\C(=N\\c(cccc3C(F)(F)F)c3)\\SC=C1c(cccc4[N+](=O)[O-])c4.Br",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound N1(Cc2ccccc2)\\C(=N\\c(cccc3C(F)(F)F)c3)\\SC=C1c(cccc4[N+](=O)[O-])c4.Br?",
    "answer":"No",
    "_id":5525
  },
  {
    "COADD_ID":"CO-ADD:0245770",
    "INHIB_AVE":7.9,
    "SMILES":"c1(c(cc(cc2c3nnc(c4ccccc4)o3)NC(=O)c(cc5)ccc5[N+](=O)[O-])c2)nnc(c6ccccc6)o1",
    "HIT":0.0,
    "question":"Can exposure to c1(c(cc(cc2c3nnc(c4ccccc4)o3)NC(=O)c(cc5)ccc5[N+](=O)[O-])c2)nnc(c6ccccc6)o1 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":23571
  },
  {
    "COADD_ID":"CO-ADD:0137839",
    "INHIB_AVE":8.97,
    "SMILES":"ClC(C(OCO1)=C1C(OC)=C2OC)=C2C3=NOC(CO)=C3",
    "HIT":0.0,
    "question":"Is ClC(C(OCO1)=C1C(OC)=C2OC)=C2C3=NOC(CO)=C3 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":19980
  },
  {
    "COADD_ID":"CO-ADD:0157116",
    "INHIB_AVE":16.16,
    "SMILES":"[O-][N+](C(C=C1[N+]([O-])=O)=C(C=C1)OC(C=C2)=CC=C2\/C=N\/C3=CC(C4=NC(C=C5C)=C(C=C5)O4)=C(O)C=C3)=O",
    "HIT":0.0,
    "question":"Does the proposed molecule [O-][N+](C(C=C1[N+]([O-])=O)=C(C=C1)OC(C=C2)=CC=C2\/C=N\/C3=CC(C4=NC(C=C5C)=C(C=C5)O4)=C(O)C=C3)=O exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":6183
  },
  {
    "COADD_ID":"CO-ADD:0285806",
    "INHIB_AVE":-10.46,
    "SMILES":"c1(ccc(C=O)o1)c2cc(OC)c(cc2OC)Cl",
    "HIT":0.0,
    "question":"Does c1(ccc(C=O)o1)c2cc(OC)c(cc2OC)Cl show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":79051
  },
  {
    "COADD_ID":"CO-ADD:0255694",
    "INHIB_AVE":1.06,
    "SMILES":"[N+](=O)([O-])c1cc(ccc1Cl)\\C=N\\c2ccccc2c3ccccc3\\N=C\\c(ccc(c4[N+](=O)[O-])Cl)c4",
    "HIT":0.0,
    "question":"Does the proposed molecule [N+](=O)([O-])c1cc(ccc1Cl)\\C=N\\c2ccccc2c3ccccc3\\N=C\\c(ccc(c4[N+](=O)[O-])Cl)c4 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":53219
  },
  {
    "COADD_ID":"CO-ADD:0134097",
    "INHIB_AVE":1.3,
    "SMILES":"O=C(c1[nH]c([N+](=O)[O-])cn1)NC",
    "HIT":0.0,
    "question":"Does O=C(c1[nH]c([N+](=O)[O-])cn1)NC show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":52169
  },
  {
    "COADD_ID":"CO-ADD:0222776",
    "INHIB_AVE":3.8,
    "SMILES":"c1(\\C=N\\NC(COc2c(C)cc(cc2C)Br)=O)c3c(cccc3)cc(cccc4)c14",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(\\C=N\\NC(COc2c(C)cc(cc2C)Br)=O)c3c(cccc3)cc(cccc4)c14?",
    "answer":"No",
    "_id":41101
  },
  {
    "COADD_ID":"CO-ADD:0301747",
    "INHIB_AVE":3.17,
    "SMILES":"C(=O)(CN(CC1)CCN1Cc2ccccc2)Nc(cc3)ccc3F",
    "HIT":0.0,
    "question":"Does the proposed molecule C(=O)(CN(CC1)CCN1Cc2ccccc2)Nc(cc3)ccc3F exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":43849
  },
  {
    "COADD_ID":"CO-ADD:0287164",
    "INHIB_AVE":2.52,
    "SMILES":"c1(cc(ccc1Oc(cc2)ccc2F)NC(COc3ccccc3Cl)=O)C(F)(F)F",
    "HIT":0.0,
    "question":"Can c1(cc(ccc1Oc(cc2)ccc2F)NC(COc3ccccc3Cl)=O)C(F)(F)F effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":46813
  },
  {
    "COADD_ID":"CO-ADD:0160584",
    "INHIB_AVE":6.95,
    "SMILES":"[O-][N+](C1=CC(\/C=N\/NC(C(CC2=CC=CC=C2)C(N\/N=C\/C3=CC=C(OC(C4=CC=CC5=C4C=CC=C5)=O)C([N+]([O-])=O)=C3)=O)=O)=CC=C1OC(C6=CC=CC7=C6C=CC=C7)=O)=O",
    "HIT":0.0,
    "question":"Can [O-][N+](C1=CC(\/C=N\/NC(C(CC2=CC=CC=C2)C(N\/N=C\/C3=CC=C(OC(C4=CC=CC5=C4C=CC=C5)=O)C([N+]([O-])=O)=C3)=O)=O)=CC=C1OC(C6=CC=CC7=C6C=CC=C7)=O)=O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":27184
  },
  {
    "COADD_ID":"CO-ADD:0255312",
    "INHIB_AVE":-21.2,
    "SMILES":"C(=N)(N1CCCCC1)\\C(\\C#N)=N\\Nc2cccc(F)c2",
    "HIT":0.0,
    "question":"Does treatment with C(=N)(N1CCCCC1)\\C(\\C#N)=N\\Nc2cccc(F)c2 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":82268
  },
  {
    "COADD_ID":"CO-ADD:0245315",
    "INHIB_AVE":-5.51,
    "SMILES":"c1(C(=O)c2cc(OC)ccc2OC)oc(c3c1NC(C)=O)cccc3",
    "HIT":0.0,
    "question":"Does the proposed molecule c1(C(=O)c2cc(OC)ccc2OC)oc(c3c1NC(C)=O)cccc3 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":72861
  },
  {
    "COADD_ID":"CO-ADD:0283658",
    "INHIB_AVE":9.94,
    "SMILES":"N1(c2ccc(c(Cl)c2)Cl)CC(CC1=O)C(O)=O",
    "HIT":0.0,
    "question":"Does N1(c2ccc(c(Cl)c2)Cl)CC(CC1=O)C(O)=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":17165
  },
  {
    "COADD_ID":"CO-ADD:0157664",
    "INHIB_AVE":16.09,
    "SMILES":"S=C(NC1=O)NC(C1=CC(C=C2)=CC=C2C)=O",
    "HIT":0.0,
    "question":"Can S=C(NC1=O)NC(C1=CC(C=C2)=CC=C2C)=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":6255
  },
  {
    "COADD_ID":"CO-ADD:0156069",
    "INHIB_AVE":2.3,
    "SMILES":"O=C1\/C(N=C(C2=CC=CC(I)=C2)O1)=C\/C3=CC(OC)=C(OC)C(OC)=C3",
    "HIT":0.0,
    "question":"Does O=C1\/C(N=C(C2=CC=CC(I)=C2)O1)=C\/C3=CC(OC)=C(OC)C(OC)=C3 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":47747
  },
  {
    "COADD_ID":"CO-ADD:0155568",
    "INHIB_AVE":6.2,
    "SMILES":"C1(C2=NC(C=CC=C3)=C3C=C2)=NC4=C(C(C=CC=C5)=C5C=C4)C6=C1CCC6",
    "HIT":0.0,
    "question":"Does treatment with C1(C2=NC(C=CC=C3)=C3C=C2)=NC4=C(C(C=CC=C5)=C5C=C4)C6=C1CCC6 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":30406
  },
  {
    "COADD_ID":"CO-ADD:0257887",
    "INHIB_AVE":13.2,
    "SMILES":"S(c1ccccc1)(=O)(=O)N(CC2)CCN2C(c3ccccc3)c4ccccc4",
    "HIT":0.0,
    "question":"Does treatment with S(c1ccccc1)(=O)(=O)N(CC2)CCN2C(c3ccccc3)c4ccccc4 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":10255
  },
  {
    "COADD_ID":"CO-ADD:0218593",
    "INHIB_AVE":0.39,
    "SMILES":"c1(Cl)cc(Cl)ccc1\\C=N\\OCO\\N=C\\c2ccc(cc2Cl)Cl",
    "HIT":0.0,
    "question":"Can exposure to c1(Cl)cc(Cl)ccc1\\C=N\\OCO\\N=C\\c2ccc(cc2Cl)Cl lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":55887
  },
  {
    "COADD_ID":"CO-ADD:0158369",
    "INHIB_AVE":13.76,
    "SMILES":"O=C(COC1=CC(C)=CC=C1C(C)C)N\/N=C(C)\/C2=CC=CS2",
    "HIT":0.0,
    "question":"Does treatment with O=C(COC1=CC(C)=CC=C1C(C)C)N\/N=C(C)\/C2=CC=CS2 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":9393
  },
  {
    "COADD_ID":"CO-ADD:0229990",
    "INHIB_AVE":10.59,
    "SMILES":"N#CCC(=O)N\\N=C\\c1cccc(Cl)c1Cl",
    "HIT":0.0,
    "question":"Does treatment with N#CCC(=O)N\\N=C\\c1cccc(Cl)c1Cl result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":15512
  },
  {
    "COADD_ID":"CO-ADD:0320325",
    "INHIB_AVE":2.04,
    "SMILES":"C(=N\\c1ccccc1)(\/SC(C(=O)Nc(cc2)ccc2OC(F)(Cl)F)CC3=O)\\N3CCc4ccccc4",
    "HIT":0.0,
    "question":"Does the proposed molecule C(=N\\c1ccccc1)(\/SC(C(=O)Nc(cc2)ccc2OC(F)(Cl)F)CC3=O)\\N3CCc4ccccc4 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":48901
  },
  {
    "COADD_ID":"CO-ADD:0230814",
    "INHIB_AVE":5.9,
    "SMILES":"C(=O)(N\\N=C\\c1ccc(C)o1)C(=O)Nc2cccc(F)c2",
    "HIT":0.0,
    "question":"Does the proposed molecule C(=O)(N\\N=C\\c1ccc(C)o1)C(=O)Nc2cccc(F)c2 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":31694
  },
  {
    "COADD_ID":"CO-ADD:0250635",
    "INHIB_AVE":7.77,
    "SMILES":"n1(c2ccccc2)nnnc1SCC(=O)c3ccc(cc3)CC",
    "HIT":0.0,
    "question":"Can exposure to n1(c2ccccc2)nnnc1SCC(=O)c3ccc(cc3)CC lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":24068
  },
  {
    "COADD_ID":"CO-ADD:0230682",
    "INHIB_AVE":4.81,
    "SMILES":"c1(ccccc1Br)C(=O)N\\N=C(\/C2)\\c3c(CC2)cccc3",
    "HIT":0.0,
    "question":"Is c1(ccccc1Br)C(=O)N\\N=C(\/C2)\\c3c(CC2)cccc3 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":36477
  },
  {
    "COADD_ID":"CO-ADD:0228012",
    "INHIB_AVE":6.3,
    "SMILES":"C(c1ccccc1)(=O)Oc(cc2)ccc2\\C=N\/NC(CNC(=O)C(c3ccccc3)c4ccccc4)=O",
    "HIT":0.0,
    "question":"Can C(c1ccccc1)(=O)Oc(cc2)ccc2\\C=N\/NC(CNC(=O)C(c3ccccc3)c4ccccc4)=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":30000
  },
  {
    "COADD_ID":"CO-ADD:0242507",
    "INHIB_AVE":1.48,
    "SMILES":"c1(N(C)C)nc(NCc2ccccc2)nc(N\\N=C(\/C)\\c3ccc(cc3)NC(C)=O)n1",
    "HIT":0.0,
    "question":"Can exposure to c1(N(C)C)nc(NCc2ccccc2)nc(N\\N=C(\/C)\\c3ccc(cc3)NC(C)=O)n1 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":51384
  },
  {
    "COADD_ID":"CO-ADD:0311209",
    "INHIB_AVE":12.11,
    "SMILES":"C(=O)(N1CCCCC1)c2ccccc2C(=O)Nc3ccccc3",
    "HIT":0.0,
    "question":"Is C(=O)(N1CCCCC1)c2ccccc2C(=O)Nc3ccccc3 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":12247
  },
  {
    "COADD_ID":"CO-ADD:0320645",
    "INHIB_AVE":-0.16,
    "SMILES":"N1(Cc(cc2)ccc2Cl)\\C(=N\\c(ccc(c3Cl)Cl)c3)\\SC(C(=O)Nc(cc4)ccc4OC(F)(F)Cl)CC1=O",
    "HIT":0.0,
    "question":"Does N1(Cc(cc2)ccc2Cl)\\C(=N\\c(ccc(c3Cl)Cl)c3)\\SC(C(=O)Nc(cc4)ccc4OC(F)(F)Cl)CC1=O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":58112
  },
  {
    "COADD_ID":"CO-ADD:0300835",
    "INHIB_AVE":2.26,
    "SMILES":"N1(CCC(O)=O)C(=O)\\C(\\SC1=S)=C\\c2cccc(OC)c2OC",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound N1(CCC(O)=O)C(=O)\\C(\\SC1=S)=C\\c2cccc(OC)c2OC?",
    "answer":"No",
    "_id":47946
  },
  {
    "COADD_ID":"CO-ADD:0294665",
    "INHIB_AVE":13.41,
    "SMILES":"c1(C(c2ccccc2)=O)oc(c3c1NC(CCl)=O)cccc3",
    "HIT":0.0,
    "question":"Is c1(C(c2ccccc2)=O)oc(c3c1NC(CCl)=O)cccc3 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":9907
  },
  {
    "COADD_ID":"CO-ADD:0217042",
    "INHIB_AVE":6.24,
    "SMILES":"C1(=COC(=O)C=C1)C(=O)Nc2cc(C)ccc2C",
    "HIT":0.0,
    "question":"Does treatment with C1(=COC(=O)C=C1)C(=O)Nc2cc(C)ccc2C result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":30246
  },
  {
    "COADD_ID":"CO-ADD:0302545",
    "INHIB_AVE":-11.06,
    "SMILES":"C12=C(CC(c3ccc(cc3)OC)CC1=O)Nc(c4NC2c5ccccc5F)cccc4",
    "HIT":0.0,
    "question":"Does C12=C(CC(c3ccc(cc3)OC)CC1=O)Nc(c4NC2c5ccccc5F)cccc4 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":79461
  },
  {
    "COADD_ID":"CO-ADD:0301804",
    "INHIB_AVE":-11.64,
    "SMILES":"c12c(ccc(cccc3)c13)C(CC(=O)N2)c(cc4OC)cc(c4OC(C)=O)OC",
    "HIT":0.0,
    "question":"Does c12c(ccc(cccc3)c13)C(CC(=O)N2)c(cc4OC)cc(c4OC(C)=O)OC demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":79802
  },
  {
    "COADD_ID":"CO-ADD:0237015",
    "INHIB_AVE":1.42,
    "SMILES":"OCC(C)(C)[C@@H](O)C(NCCC(NCCCCCCC)=S)=O",
    "HIT":0.0,
    "question":"Is OCC(C)(C)[C@@H](O)C(NCCC(NCCCCCCC)=S)=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":51628
  },
  {
    "COADD_ID":"CO-ADD:0278218",
    "INHIB_AVE":19.79,
    "SMILES":"S1(=O)(=O)c(cccc2)c2C(Nc(ccc(c3CN(CC)CC)OC(=O)c4ccc(cc4)OC)c3)=N1.Cl",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound S1(=O)(=O)c(cccc2)c2C(Nc(ccc(c3CN(CC)CC)OC(=O)c4ccc(cc4)OC)c3)=N1.Cl?",
    "answer":"No",
    "_id":3002
  },
  {
    "COADD_ID":"CO-ADD:0330746",
    "INHIB_AVE":0.73,
    "SMILES":"C(O)(C(OC)=O)(C(F)(F)F)c1c(C)cc(c(C)c1)O",
    "HIT":0.0,
    "question":"Can exposure to C(O)(C(OC)=O)(C(F)(F)F)c1c(C)cc(c(C)c1)O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":54579
  },
  {
    "COADD_ID":"CO-ADD:0332564",
    "INHIB_AVE":9.01,
    "SMILES":"S(CC)(=O)(=O)N(CC1)CCN1c(cc2)cc(c2[N+](=O)[O-])NC(C)C34CC(CC5C3)CC(C5)C4",
    "HIT":0.0,
    "question":"Is S(CC)(=O)(=O)N(CC1)CCN1c(cc2)cc(c2[N+](=O)[O-])NC(C)C34CC(CC5C3)CC(C5)C4 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":19864
  },
  {
    "COADD_ID":"CO-ADD:0283117",
    "INHIB_AVE":4.65,
    "SMILES":"C(C(=O)OCC1CCCO1)(C2c3ccc(cc3)SC)=C(C)NC(CCCC4=O)=C24",
    "HIT":0.0,
    "question":"Does treatment with C(C(=O)OCC1CCCO1)(C2c3ccc(cc3)SC)=C(C)NC(CCCC4=O)=C24 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":37245
  },
  {
    "COADD_ID":"CO-ADD:0259584",
    "INHIB_AVE":-8.34,
    "SMILES":"N1(C2c3ccc(c4c3)OCO4)C(S\\C(=C\\c5cc(Cl)ccc5O)\\C1=O)=NC(C)=C2C(OCC)=O",
    "HIT":0.0,
    "question":"Does N1(C2c3ccc(c4c3)OCO4)C(S\\C(=C\\c5cc(Cl)ccc5O)\\C1=O)=NC(C)=C2C(OCC)=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":77119
  },
  {
    "COADD_ID":"CO-ADD:0293062",
    "INHIB_AVE":-0.36,
    "SMILES":"C(C(C)=O)(C1c2ccccc2Cl)=C(O)C(N1CCN(CC3)CCN3)=O",
    "HIT":0.0,
    "question":"Is C(C(C)=O)(C1c2ccccc2Cl)=C(O)C(N1CCN(CC3)CCN3)=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":58842
  },
  {
    "COADD_ID":"CO-ADD:0243621",
    "INHIB_AVE":1.75,
    "SMILES":"c(O1)(cc(CO)c2OC)c(OC1)c2OC",
    "HIT":0.0,
    "question":"Does c(O1)(cc(CO)c2OC)c(OC1)c2OC show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":50236
  },
  {
    "COADD_ID":"CO-ADD:0284772",
    "INHIB_AVE":-1.29,
    "SMILES":"c(c(c1c(C2=O)cccc1)on3)(c2ccc4N(CC5)CCN5c6ccccc6)c34",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c(c(c1c(C2=O)cccc1)on3)(c2ccc4N(CC5)CCN5c6ccccc6)c34?",
    "answer":"No",
    "_id":62042
  },
  {
    "COADD_ID":"CO-ADD:0219788",
    "INHIB_AVE":-4.92,
    "SMILES":"[N+]([O-])(c1ccc(cc1)OCCCCCCCCC)=Nc(cc2)ccc2OCCCCCCCCC",
    "HIT":0.0,
    "question":"Can [N+]([O-])(c1ccc(cc1)OCCCCCCCCC)=Nc(cc2)ccc2OCCCCCCCCC effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":71727
  },
  {
    "COADD_ID":"CO-ADD:0219326",
    "INHIB_AVE":8.21,
    "SMILES":"c1(SCC(=O)Nc2ccccc2)nc(cc(C)c1C#N)C(F)(F)F",
    "HIT":0.0,
    "question":"Is c1(SCC(=O)Nc2ccccc2)nc(cc(C)c1C#N)C(F)(F)F capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":22453
  },
  {
    "COADD_ID":"CO-ADD:0148574",
    "INHIB_AVE":-7.94,
    "SMILES":"O=C(C1=CC(O)=CC=C1O)\/C=C\/C2=CNC3=CC=C(O)C=C32",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound O=C(C1=CC(O)=CC=C1O)\/C=C\/C2=CNC3=CC=C(O)C=C32?",
    "answer":"No",
    "_id":76635
  },
  {
    "COADD_ID":"CO-ADD:0258856",
    "INHIB_AVE":5.73,
    "SMILES":"c1(ccc(cc1Cl)NC(C)=O)Oc(cc2)ccc2Cl",
    "HIT":0.0,
    "question":"Can c1(ccc(cc1Cl)NC(C)=O)Oc(cc2)ccc2Cl effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":32404
  },
  {
    "COADD_ID":"CO-ADD:0219515",
    "INHIB_AVE":-7.33,
    "SMILES":"[N+](=O)([O-])c1c(ccc(c1)[N+](=O)[O-])CC(=O)N\\N=C(\/C)\\CC(=O)Nc(cc2)ccc2I",
    "HIT":0.0,
    "question":"Can [N+](=O)([O-])c1c(ccc(c1)[N+](=O)[O-])CC(=O)N\\N=C(\/C)\\CC(=O)Nc(cc2)ccc2I act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":75813
  },
  {
    "COADD_ID":"CO-ADD:0294459",
    "INHIB_AVE":13.05,
    "SMILES":"c1(nnc(c(cccc2[N+](=O)[O-])c2)n1C)S(N)(=O)=O",
    "HIT":0.0,
    "question":"Can c1(nnc(c(cccc2[N+](=O)[O-])c2)n1C)S(N)(=O)=O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":10476
  },
  {
    "COADD_ID":"CO-ADD:0221270",
    "INHIB_AVE":1.62,
    "SMILES":"c1(C(OCC)=O)c(cc(OC)cc2)c2n(CCC(O)=O)c1C",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(C(OCC)=O)c(cc(OC)cc2)c2n(CCC(O)=O)c1C?",
    "answer":"No",
    "_id":50804
  },
  {
    "COADD_ID":"CO-ADD:0226168",
    "INHIB_AVE":6.29,
    "SMILES":"S(=O)(=O)(N(c1ccc(cc1)CC)Cc(cc2F)cc(c2)F)c3cccn(c(nn4)C)c34",
    "HIT":0.0,
    "question":"Is S(=O)(=O)(N(c1ccc(cc1)CC)Cc(cc2F)cc(c2)F)c3cccn(c(nn4)C)c34 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":30062
  },
  {
    "COADD_ID":"CO-ADD:0305553",
    "INHIB_AVE":0.95,
    "SMILES":"[N+](=O)([O-])c1cccc(Cl)c1NCCNC(=O)c2ccc(cc2)C",
    "HIT":0.0,
    "question":"Is [N+](=O)([O-])c1cccc(Cl)c1NCCNC(=O)c2ccc(cc2)C capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":53683
  },
  {
    "COADD_ID":"CO-ADD:0245832",
    "INHIB_AVE":4.92,
    "SMILES":"C(\/S(CC)(=O)=O)(\\S(CC)(=O)=O)=C(\\Nc(ccc(c12)cccc1)c2)\/Nc(ccc(c34)cccc3)c4",
    "HIT":0.0,
    "question":"Can exposure to C(\/S(CC)(=O)=O)(\\S(CC)(=O)=O)=C(\\Nc(ccc(c12)cccc1)c2)\/Nc(ccc(c34)cccc3)c4 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":35984
  },
  {
    "COADD_ID":"CO-ADD:0149363",
    "INHIB_AVE":4.95,
    "SMILES":"c(c(OC)ccc1\\C(\\C#N)=C\\c(cc(OC)c(OC)c2OC)c2)c1",
    "HIT":0.0,
    "question":"Is c(c(OC)ccc1\\C(\\C#N)=C\\c(cc(OC)c(OC)c2OC)c2)c1 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":35848
  },
  {
    "COADD_ID":"CO-ADD:0232056",
    "INHIB_AVE":-17.67,
    "SMILES":"C(=O)(Oc1ccc(cc1OC)\\C=N\\NC(COc2cccc(Cl)c2)=O)c3ccccc3Cl",
    "HIT":0.0,
    "question":"Can exposure to C(=O)(Oc1ccc(cc1OC)\\C=N\\NC(COc2cccc(Cl)c2)=O)c3ccccc3Cl lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":81860
  },
  {
    "COADD_ID":"CO-ADD:0135948",
    "INHIB_AVE":4.02,
    "SMILES":"Clc(nc(c1c2Cl)N([H])C(=O)N1[H])n2",
    "HIT":0.0,
    "question":"Does Clc(nc(c1c2Cl)N([H])C(=O)N1[H])n2 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":40075
  },
  {
    "COADD_ID":"CO-ADD:0243502",
    "INHIB_AVE":-6.97,
    "SMILES":"c(OC1)(c(OC)c(OC)c2c(nc(CCC(=O)O)o3)n3)c(O1)c2",
    "HIT":0.0,
    "question":"Does c(OC1)(c(OC)c(OC)c2c(nc(CCC(=O)O)o3)n3)c(O1)c2 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":75285
  },
  {
    "COADD_ID":"CO-ADD:0254001",
    "INHIB_AVE":-24.05,
    "SMILES":"S(=O)(=O)(N1CCCCC1)c(ccc(c2C(=O)Oc(cccc3NC(=O)c4cccc(OC)c4)c3)Cl)c2",
    "HIT":0.0,
    "question":"Can S(=O)(=O)(N1CCCCC1)c(ccc(c2C(=O)Oc(cccc3NC(=O)c4cccc(OC)c4)c3)Cl)c2 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":82428
  },
  {
    "COADD_ID":"CO-ADD:0259769",
    "INHIB_AVE":-9.73,
    "SMILES":"C(\/SC(N1C)=S)(\\C1=O)=C(\/Sc(c23)ccc(Cl)c2)\\N3C4CCCCC4",
    "HIT":0.0,
    "question":"Does the proposed molecule C(\/SC(N1C)=S)(\\C1=O)=C(\/Sc(c23)ccc(Cl)c2)\\N3C4CCCCC4 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":78498
  },
  {
    "COADD_ID":"CO-ADD:0252790",
    "INHIB_AVE":7.73,
    "SMILES":"n12c(S\\C(=C\\c(ccc(c34)OCO3)c4)\\C1=O)nc(cc(C)c(C)c5)c25",
    "HIT":0.0,
    "question":"Can n12c(S\\C(=C\\c(ccc(c34)OCO3)c4)\\C1=O)nc(cc(C)c(C)c5)c25 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":24228
  },
  {
    "COADD_ID":"CO-ADD:0332516",
    "INHIB_AVE":-12.1,
    "SMILES":"C(=O)(c(ccc(c1Cl)Cl)c1)Nc2c(CCC)cc(c3c2)OCO3",
    "HIT":0.0,
    "question":"Can C(=O)(c(ccc(c1Cl)Cl)c1)Nc2c(CCC)cc(c3c2)OCO3 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":80083
  },
  {
    "COADD_ID":"CO-ADD:0323915",
    "INHIB_AVE":4.05,
    "SMILES":"n1c(N)n[nH]c1CC(=O)N(Cc2ccccc2)C3(CCCCC3)C(=O)Nc4ccccc4",
    "HIT":0.0,
    "question":"Can n1c(N)n[nH]c1CC(=O)N(Cc2ccccc2)C3(CCCCC3)C(=O)Nc4ccccc4 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":39938
  },
  {
    "COADD_ID":"CO-ADD:0250312",
    "INHIB_AVE":1.25,
    "SMILES":"n(c1C)(nnc1C(=O)N\\N=C(\/CCC2)\\C2)c3nonc3N",
    "HIT":0.0,
    "question":"Can n(c1C)(nnc1C(=O)N\\N=C(\/CCC2)\\C2)c3nonc3N act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":52352
  },
  {
    "COADD_ID":"CO-ADD:0312475",
    "INHIB_AVE":23.03,
    "SMILES":"[C@@H]12O[C@@]3(C=C1)[C@@H]([C@H]2C(=O)OCC)C(N(c4ccccc4)C3)=O",
    "HIT":0.0,
    "question":"Does treatment with [C@@H]12O[C@@]3(C=C1)[C@@H]([C@H]2C(=O)OCC)C(N(c4ccccc4)C3)=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":1609
  },
  {
    "COADD_ID":"CO-ADD:0305805",
    "INHIB_AVE":-11.31,
    "SMILES":"c1(NC(=O)c2ccc(c(OC)c2)OCc3cccc(F)c3)sc(c(C)c1C(OC)=O)C",
    "HIT":0.0,
    "question":"Does c1(NC(=O)c2ccc(c(OC)c2)OCc3cccc(F)c3)sc(c(C)c1C(OC)=O)C demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":79605
  },
  {
    "COADD_ID":"CO-ADD:0219698",
    "INHIB_AVE":1.58,
    "SMILES":"N#CCC(=O)N\\N=C\\c1ccccc1OCCCC",
    "HIT":0.0,
    "question":"Is N#CCC(=O)N\\N=C\\c1ccccc1OCCCC effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":50923
  },
  {
    "COADD_ID":"CO-ADD:0328028",
    "INHIB_AVE":17.42,
    "SMILES":"C12(OC(C(C(N3c4c(Cl)ccc(c4)C(F)(F)F)=O)C1C3=O)c5ccccc5)C(=O)c6c(cccc6)C2=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C12(OC(C(C(N3c4c(Cl)ccc(c4)C(F)(F)F)=O)C1C3=O)c5ccccc5)C(=O)c6c(cccc6)C2=O?",
    "answer":"No",
    "_id":4871
  },
  {
    "COADD_ID":"CO-ADD:0135791",
    "INHIB_AVE":-12.47,
    "SMILES":"C1C(C)N2C(=NCC2)C1(C)C",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C1C(C)N2C(=NCC2)C1(C)C?",
    "answer":"No",
    "_id":80287
  },
  {
    "COADD_ID":"CO-ADD:0234230",
    "INHIB_AVE":3.0,
    "SMILES":"C(=O)(Oc1cccc(c1)\\C=N\\NC(CNC(=O)c2ccc(c(OC)c2)OC)=O)c3ccccc3Br",
    "HIT":0.0,
    "question":"Does C(=O)(Oc1cccc(c1)\\C=N\\NC(CNC(=O)c2ccc(c(OC)c2)OC)=O)c3ccccc3Br demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":44671
  },
  {
    "COADD_ID":"CO-ADD:0242214",
    "INHIB_AVE":-7.74,
    "SMILES":"C(=O)(C1CCCN1CCN(C)C)Nc2c(C)cc(cc2C)C",
    "HIT":0.0,
    "question":"Does C(=O)(C1CCCN1CCN(C)C)Nc2c(C)cc(cc2C)C show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":76392
  },
  {
    "COADD_ID":"CO-ADD:0230563",
    "INHIB_AVE":7.54,
    "SMILES":"C(=N\/OC(c1ccccc1)=O)(\/c2c3cccc2)\\c4c3cccc4",
    "HIT":0.0,
    "question":"Is C(=N\/OC(c1ccccc1)=O)(\/c2c3cccc2)\\c4c3cccc4 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":24897
  },
  {
    "COADD_ID":"CO-ADD:0222713",
    "INHIB_AVE":16.99,
    "SMILES":"N1(CNc2ccccc2C(OC)=O)C(=O)\\C(\\SC1=O)=C\/c(cc3OC)cc(c3OC)OC",
    "HIT":0.0,
    "question":"Does N1(CNc2ccccc2C(OC)=O)C(=O)\\C(\\SC1=O)=C\/c(cc3OC)cc(c3OC)OC show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":5300
  },
  {
    "COADD_ID":"CO-ADD:0164446",
    "INHIB_AVE":8.11,
    "SMILES":"Cc1ccc(cc1)N(CC1=NCCN1)c1cccc(O)c1",
    "HIT":0.0,
    "question":"Does Cc1ccc(cc1)N(CC1=NCCN1)c1cccc(O)c1 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":22793
  },
  {
    "COADD_ID":"CO-ADD:0287898",
    "INHIB_AVE":5.98,
    "SMILES":"C(C(OCC)=O)(C(F)(F)F)(NC(=O)c1ccc(cc1)F)Nc2sc(c3c2C(OC)=O)CCCC3",
    "HIT":0.0,
    "question":"Can exposure to C(C(OCC)=O)(C(F)(F)F)(NC(=O)c1ccc(cc1)F)Nc2sc(c3c2C(OC)=O)CCCC3 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":31354
  },
  {
    "COADD_ID":"CO-ADD:0278247",
    "INHIB_AVE":16.6,
    "SMILES":"C(=CC(\\C=C\\c1cccc(OC)c1OC)=NC2=O)(C(F)(F)F)N2",
    "HIT":0.0,
    "question":"Does treatment with C(=CC(\\C=C\\c1cccc(OC)c1OC)=NC2=O)(C(F)(F)F)N2 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":5696
  },
  {
    "COADD_ID":"CO-ADD:0242228",
    "INHIB_AVE":7.92,
    "SMILES":"[N+](=O)([O-])c(ccc(c1c2ccc(\\C=N\\NC(=O)c(cccn3)c3)o2)Cl)c1",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound [N+](=O)([O-])c(ccc(c1c2ccc(\\C=N\\NC(=O)c(cccn3)c3)o2)Cl)c1?",
    "answer":"No",
    "_id":23523
  },
  {
    "COADD_ID":"CO-ADD:0303166",
    "INHIB_AVE":0.06,
    "SMILES":"N1(c2ccc(cc2)OC)C(=O)NC(\\C(=C\/c3cc(Br)ccc3OCCOc(cc(CC)cc4C)c4)\\C1=O)=O",
    "HIT":0.0,
    "question":"Does N1(c2ccc(cc2)OC)C(=O)NC(\\C(=C\/c3cc(Br)ccc3OCCOc(cc(CC)cc4C)c4)\\C1=O)=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":57221
  },
  {
    "COADD_ID":"CO-ADD:0277736",
    "INHIB_AVE":-5.91,
    "SMILES":"c12c(c3c(cccc3)OC1=O)nc(c(cc4)ccc4C(C)C)nc2NC(C)=O",
    "HIT":0.0,
    "question":"Can c12c(c3c(cccc3)OC1=O)nc(c(cc4)ccc4C(C)C)nc2NC(C)=O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":73552
  },
  {
    "COADD_ID":"CO-ADD:0217226",
    "INHIB_AVE":8.1,
    "SMILES":"C(F)(F)(COc1ccccc1NC(=O)c2ccc(cc2)C)C(F)F",
    "HIT":0.0,
    "question":"Can C(F)(F)(COc1ccccc1NC(=O)c2ccc(cc2)C)C(F)F effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":22842
  },
  {
    "COADD_ID":"CO-ADD:0148671",
    "INHIB_AVE":11.18,
    "SMILES":"c1c(C(CC(=O)N2)c(snc3c4cccc(F)c4)c23)cc(c5c1)OCO5",
    "HIT":0.0,
    "question":"Is c1c(C(CC(=O)N2)c(snc3c4cccc(F)c4)c23)cc(c5c1)OCO5 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":14135
  },
  {
    "COADD_ID":"CO-ADD:0277496",
    "INHIB_AVE":-1.48,
    "SMILES":"C1(C(OCCOC)=O)=C(C)NC(NC1c(cc2)cc(c2OC(F)F)OC)=O",
    "HIT":0.0,
    "question":"Can exposure to C1(C(OCCOC)=O)=C(C)NC(NC1c(cc2)cc(c2OC(F)F)OC)=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":62675
  },
  {
    "COADD_ID":"CO-ADD:0240505",
    "INHIB_AVE":22.96,
    "SMILES":"C(C#N)(C1c2scc(Br)c2)=C(N)N(C(CCCC3=O)=C13)c4ccccc4",
    "HIT":0.0,
    "question":"Is C(C#N)(C1c2scc(Br)c2)=C(N)N(C(CCCC3=O)=C13)c4ccccc4 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":1627
  },
  {
    "COADD_ID":"CO-ADD:0331221",
    "INHIB_AVE":0.72,
    "SMILES":"n1(CC=C)c(SCC(=O)Nc(cc2)ccc2C(=O)OC(C)C)nnc1c3ccco3",
    "HIT":0.0,
    "question":"Can exposure to n1(CC=C)c(SCC(=O)Nc(cc2)ccc2C(=O)OC(C)C)nnc1c3ccco3 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":54634
  },
  {
    "COADD_ID":"CO-ADD:0234228",
    "INHIB_AVE":10.17,
    "SMILES":"c1(c(O)c(\\C=N\\c2ccc(cc2Cl)Cl)c(c(Cl)c1C)C)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Does c1(c(O)c(\\C=N\\c2ccc(cc2Cl)Cl)c(c(Cl)c1C)C)[N+](=O)[O-] show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":16564
  },
  {
    "COADD_ID":"CO-ADD:0225640",
    "INHIB_AVE":2.95,
    "SMILES":"C1(=N2)N(C=CN=C1Oc(cc3)ccc3C)C(N2CC(=O)Nc4ccc(cc4F)Br)=O",
    "HIT":0.0,
    "question":"Does the proposed molecule C1(=N2)N(C=CN=C1Oc(cc3)ccc3C)C(N2CC(=O)Nc4ccc(cc4F)Br)=O exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":44869
  },
  {
    "COADD_ID":"CO-ADD:0236947",
    "INHIB_AVE":3.12,
    "SMILES":"O=C(C1=CC=C(OC)C=C1CC\/2)C2=CC3=CC=CN=C3Br",
    "HIT":0.0,
    "question":"Is O=C(C1=CC=C(OC)C=C1CC\/2)C2=CC3=CC=CN=C3Br capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":44066
  },
  {
    "COADD_ID":"CO-ADD:0233044",
    "INHIB_AVE":-1.93,
    "SMILES":"N1(c2ccccc2c3ccccc3)C(=O)c(c4C1=O)ccc(c4)C(=O)Nc5ccc(cc5C(O)=O)Br",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound N1(c2ccccc2c3ccccc3)C(=O)c(c4C1=O)ccc(c4)C(=O)Nc5ccc(cc5C(O)=O)Br?",
    "answer":"No",
    "_id":64166
  },
  {
    "COADD_ID":"CO-ADD:0166323",
    "INHIB_AVE":14.81,
    "SMILES":"C(OC)(COc(cc1)ccc1C=O)=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C(OC)(COc(cc1)ccc1C=O)=O?",
    "answer":"No",
    "_id":7841
  },
  {
    "COADD_ID":"CO-ADD:0156154",
    "INHIB_AVE":11.42,
    "SMILES":"O=C(C(C=C1)=CC=C1Cl)N2C3=C(SC4=C2C=CC=C4)C=CC(Cl)=C3",
    "HIT":0.0,
    "question":"Is O=C(C(C=C1)=CC=C1Cl)N2C3=C(SC4=C2C=CC=C4)C=CC(Cl)=C3 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":13619
  },
  {
    "COADD_ID":"CO-ADD:0162954",
    "INHIB_AVE":-7.52,
    "SMILES":"S(=O)(=O)(CCC(C)=O)c1ccc(cc1)Cc(cc2)ccc2S(=O)(=O)CCC(C)=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound S(=O)(=O)(CCC(C)=O)c1ccc(cc1)Cc(cc2)ccc2S(=O)(=O)CCC(C)=O?",
    "answer":"No",
    "_id":76090
  },
  {
    "COADD_ID":"CO-ADD:0326254",
    "INHIB_AVE":5.32,
    "SMILES":"N1(c2ccc(cc2)Cl)C(=O)CC(N(C3CCCC3)C(C)=O)C1=O",
    "HIT":0.0,
    "question":"Is N1(c2ccc(cc2)Cl)C(=O)CC(N(C3CCCC3)C(C)=O)C1=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":34235
  },
  {
    "COADD_ID":"CO-ADD:0161257",
    "INHIB_AVE":-7.52,
    "SMILES":"C1(=O)N(\\N=C\\c(cccc2[N+](=O)[O-])c2)C(C)=CC(C)=C1C(N)=O",
    "HIT":0.0,
    "question":"Is C1(=O)N(\\N=C\\c(cccc2[N+](=O)[O-])c2)C(C)=CC(C)=C1C(N)=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":76097
  },
  {
    "COADD_ID":"CO-ADD:0161314",
    "INHIB_AVE":2.25,
    "SMILES":"C(C#N)(C1c(ccc(c2[N+](=O)[O-])Cl)c2)=C(N)SC(N)=C1C#N",
    "HIT":0.0,
    "question":"Can C(C#N)(C1c(ccc(c2[N+](=O)[O-])Cl)c2)=C(N)SC(N)=C1C#N effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":47986
  },
  {
    "COADD_ID":"CO-ADD:0287710",
    "INHIB_AVE":-0.2,
    "SMILES":"N1(\\N=C(\/CCCCC2)\\C2)C(=O)c3c(NC1c4ccccc4Cl)cccc3",
    "HIT":0.0,
    "question":"Does treatment with N1(\\N=C(\/CCCCC2)\\C2)C(=O)c3c(NC1c4ccccc4Cl)cccc3 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":58255
  },
  {
    "COADD_ID":"CO-ADD:0326010",
    "INHIB_AVE":-1.13,
    "SMILES":"S(=O)(=O)(Nc(cc1)ccc1OCC)c2ccc(c(C)c2Cl)Cl",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound S(=O)(=O)(Nc(cc1)ccc1OCC)c2ccc(c(C)c2Cl)Cl?",
    "answer":"No",
    "_id":61539
  },
  {
    "COADD_ID":"CO-ADD:0296119",
    "INHIB_AVE":0.49,
    "SMILES":"c1(cc(F)c(cc1Cl)F)C(=O)N(CC2)CCN2c(cc3)c4c(c3[N+](=O)[O-])cccn4",
    "HIT":0.0,
    "question":"Does c1(cc(F)c(cc1Cl)F)C(=O)N(CC2)CCN2c(cc3)c4c(c3[N+](=O)[O-])cccn4 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":55543
  },
  {
    "COADD_ID":"CO-ADD:0278342",
    "INHIB_AVE":0.69,
    "SMILES":"N1(c2cccc(Cl)c2Cl)C(=O)\\C(=C\\c3ccc(C)o3)\\C(NC1=S)=O",
    "HIT":0.0,
    "question":"Does treatment with N1(c2cccc(Cl)c2Cl)C(=O)\\C(=C\\c3ccc(C)o3)\\C(NC1=S)=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":54760
  },
  {
    "COADD_ID":"CO-ADD:0256464",
    "INHIB_AVE":-9.4,
    "SMILES":"c1(cnc(C)n1CC(NN)=O)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Can c1(cnc(C)n1CC(NN)=O)[N+](=O)[O-] act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":78235
  },
  {
    "COADD_ID":"CO-ADD:0278861",
    "INHIB_AVE":-6.07,
    "SMILES":"N1(CC(C)C)C(=O)c(c2C1=O)ccc(C(=O)c(cc3)ccc3C(O)=O)c2",
    "HIT":0.0,
    "question":"Does N1(CC(C)C)C(=O)c(c2C1=O)ccc(C(=O)c(cc3)ccc3C(O)=O)c2 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":73875
  },
  {
    "COADD_ID":"CO-ADD:0149127",
    "INHIB_AVE":-7.44,
    "SMILES":"c(c1)c([nH]2)c(c(C(=O)C(=O)Nc(cc3)ccc3OC)c2)cc1F",
    "HIT":0.0,
    "question":"Does c(c1)c([nH]2)c(c(C(=O)C(=O)Nc(cc3)ccc3OC)c2)cc1F demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":75980
  },
  {
    "COADD_ID":"CO-ADD:0255678",
    "INHIB_AVE":-2.15,
    "SMILES":"C(=O)(N\\N=C\/c1cccc(cccc2)c12)C(c3ccccc3)c4ccccc4",
    "HIT":0.0,
    "question":"Does treatment with C(=O)(N\\N=C\/c1cccc(cccc2)c12)C(c3ccccc3)c4ccccc4 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":64829
  },
  {
    "COADD_ID":"CO-ADD:0327910",
    "INHIB_AVE":-1.09,
    "SMILES":"S(=O)(=O)(Nc(cc1)ccc1O)c(ccc(c2C(O)=O)O)c2",
    "HIT":0.0,
    "question":"Is S(=O)(=O)(Nc(cc1)ccc1O)c(ccc(c2C(O)=O)O)c2 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":61387
  },
  {
    "COADD_ID":"CO-ADD:0227333",
    "INHIB_AVE":-7.19,
    "SMILES":"C(CNc1cccc(cccc2)c12)(=O)N\\N=C\\c(ccc(c3O)O)c3",
    "HIT":0.0,
    "question":"Can C(CNc1cccc(cccc2)c12)(=O)N\\N=C\\c(ccc(c3O)O)c3 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":75620
  },
  {
    "COADD_ID":"CO-ADD:0233758",
    "INHIB_AVE":8.35,
    "SMILES":"N1(CCC[C@@H](C1)c(ccn2)o2)C(=O)[C@@H]3CCCN3.Cl",
    "HIT":0.0,
    "question":"Can N1(CCC[C@@H](C1)c(ccn2)o2)C(=O)[C@@H]3CCCN3.Cl effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":21942
  },
  {
    "COADD_ID":"CO-ADD:0232115",
    "INHIB_AVE":5.87,
    "SMILES":"C(=O)(c1ccc(cc1)Cl)NCC(=O)N\\N=C\\c(ccc(c23)OCO2)c3",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C(=O)(c1ccc(cc1)Cl)NCC(=O)N\\N=C\\c(ccc(c23)OCO2)c3?",
    "answer":"No",
    "_id":31806
  },
  {
    "COADD_ID":"CO-ADD:0215412",
    "INHIB_AVE":2.96,
    "SMILES":"c(C#N)(c1c2ccccc2)c(SCc(ccc(c3Cl)Cl)c3)nc(N)c1C#N",
    "HIT":0.0,
    "question":"Does c(C#N)(c1c2ccccc2)c(SCc(ccc(c3Cl)Cl)c3)nc(N)c1C#N show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":44825
  },
  {
    "COADD_ID":"CO-ADD:0135683",
    "INHIB_AVE":-4.63,
    "SMILES":"n1cnc(c(c1Cl)cc2)n2[H]",
    "HIT":0.0,
    "question":"Is n1cnc(c(c1Cl)cc2)n2[H] effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":71095
  },
  {
    "COADD_ID":"CO-ADD:0220577",
    "INHIB_AVE":-1.93,
    "SMILES":"c1(OC)c(OC)cc(cc1OC)\\C=N\\NC(CNc2ccccc2C)=O",
    "HIT":0.0,
    "question":"Does c1(OC)c(OC)cc(cc1OC)\\C=N\\NC(CNc2ccccc2C)=O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":64152
  },
  {
    "COADD_ID":"CO-ADD:0223295",
    "INHIB_AVE":-0.89,
    "SMILES":"c1(SCC(=O)N\\N=C\\c(cc2)ccc2F)sc(c3n1)cccc3",
    "HIT":0.0,
    "question":"Is c1(SCC(=O)N\\N=C\\c(cc2)ccc2F)sc(c3n1)cccc3 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":60732
  },
  {
    "COADD_ID":"CO-ADD:0277616",
    "INHIB_AVE":7.35,
    "SMILES":"c1(NC(=O)c2cc(OC)cc(OC)c2)sc(c3c1C(OCC)=O)CCCC3",
    "HIT":0.0,
    "question":"Does the proposed molecule c1(NC(=O)c2cc(OC)cc(OC)c2)sc(c3c1C(OCC)=O)CCCC3 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":25689
  },
  {
    "COADD_ID":"CO-ADD:0230068",
    "INHIB_AVE":5.86,
    "SMILES":"[N+](=O)([O-])c1ccccc1N2CCCCC2",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound [N+](=O)([O-])c1ccccc1N2CCCCC2?",
    "answer":"No",
    "_id":31838
  },
  {
    "COADD_ID":"CO-ADD:0232143",
    "INHIB_AVE":5.88,
    "SMILES":"C(=O)(NCC(=O)N\\N=C(\/C)\\c1ccc(cc1)C)c2ccco2",
    "HIT":0.0,
    "question":"Is C(=O)(NCC(=O)N\\N=C(\/C)\\c1ccc(cc1)C)c2ccco2 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":31731
  },
  {
    "COADD_ID":"CO-ADD:0292259",
    "INHIB_AVE":1.88,
    "SMILES":"n1(c2ccccc2)nnnc1SCC(=O)N(CC3)CCN3c4sc(c(ccc5[N+](=O)[O-])n4)c5",
    "HIT":0.0,
    "question":"Does n1(c2ccccc2)nnnc1SCC(=O)N(CC3)CCN3c4sc(c(ccc5[N+](=O)[O-])n4)c5 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":49636
  },
  {
    "COADD_ID":"CO-ADD:0148977",
    "INHIB_AVE":8.98,
    "SMILES":"c1(nc(c2n1Cc3ccccn3)cccc2)c4nonc4NC(C)=O",
    "HIT":0.0,
    "question":"Is c1(nc(c2n1Cc3ccccn3)cccc2)c4nonc4NC(C)=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":19960
  },
  {
    "COADD_ID":"CO-ADD:0161859",
    "INHIB_AVE":8.02,
    "SMILES":"c1(N(CC2)CCO2)nc(N\\N=C\\c(cc(Br)cc3Br)c3O)nc(Nc4cc(C)ccc4C)n1",
    "HIT":0.0,
    "question":"Does c1(N(CC2)CCO2)nc(N\\N=C\\c(cc(Br)cc3Br)c3O)nc(Nc4cc(C)ccc4C)n1 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":23128
  },
  {
    "COADD_ID":"CO-ADD:0290542",
    "INHIB_AVE":-0.13,
    "SMILES":"C12=C(CC(C)(C)CC1=O)c3c(ccc(cccc4)c34)NC2c5ccc(c(OC)c5OC)OC",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C12=C(CC(C)(C)CC1=O)c3c(ccc(cccc4)c34)NC2c5ccc(c(OC)c5OC)OC?",
    "answer":"No",
    "_id":57993
  },
  {
    "COADD_ID":"CO-ADD:0241537",
    "INHIB_AVE":10.82,
    "SMILES":"C(C1)(CC2CC1CC3C2)(C3)NC(=O)C\\C(\\C)=N\\NC(=O)c4ccc(cc4)NC(C)=O",
    "HIT":0.0,
    "question":"Is C(C1)(CC2CC1CC3C2)(C3)NC(=O)C\\C(\\C)=N\\NC(=O)c4ccc(cc4)NC(C)=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":14953
  },
  {
    "COADD_ID":"CO-ADD:0227210",
    "INHIB_AVE":6.32,
    "SMILES":"c1(c(O)c(\\C=N\\c2cc(CC)ccc2O)cc(c1)[N+](=O)[O-])[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Can exposure to c1(c(O)c(\\C=N\\c2cc(CC)ccc2O)cc(c1)[N+](=O)[O-])[N+](=O)[O-] lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":29903
  },
  {
    "COADD_ID":"CO-ADD:0289259",
    "INHIB_AVE":4.63,
    "SMILES":"c1(C2CCCCN2)nncn1C.Cl.Cl",
    "HIT":0.0,
    "question":"Does c1(C2CCCCN2)nncn1C.Cl.Cl demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":37321
  },
  {
    "COADD_ID":"CO-ADD:0222492",
    "INHIB_AVE":-4.75,
    "SMILES":"[N+](=O)([O-])c(c1)cc(c(O)c1\\C=N\\c2cccc(Cl)c2Cl)OC",
    "HIT":0.0,
    "question":"Is [N+](=O)([O-])c(c1)cc(c(O)c1\\C=N\\c2cccc(Cl)c2Cl)OC capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":71328
  },
  {
    "COADD_ID":"CO-ADD:0227995",
    "INHIB_AVE":-3.58,
    "SMILES":"[N+](=O)([O-])c1cccc(\\C(\\C)=N\\NC(COc2ccc(cc2OC)Br)=O)c1",
    "HIT":0.0,
    "question":"Can [N+](=O)([O-])c1cccc(\\C(\\C)=N\\NC(COc2ccc(cc2OC)Br)=O)c1 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":68726
  },
  {
    "COADD_ID":"CO-ADD:0290986",
    "INHIB_AVE":-0.27,
    "SMILES":"c1(SCCOc(cc2)ccc2C)nc(c3n1CC(O)=O)cccc3",
    "HIT":0.0,
    "question":"Is c1(SCCOc(cc2)ccc2C)nc(c3n1CC(O)=O)cccc3 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":58508
  },
  {
    "COADD_ID":"CO-ADD:0252950",
    "INHIB_AVE":10.33,
    "SMILES":"S(CCCCCCCCCC)(=O)(=O)N\\N=C\\c(cccc1[N+](=O)[O-])c1",
    "HIT":0.0,
    "question":"Is S(CCCCCCCCCC)(=O)(=O)N\\N=C\\c(cccc1[N+](=O)[O-])c1 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":16176
  },
  {
    "COADD_ID":"CO-ADD:0155675",
    "INHIB_AVE":-3.55,
    "SMILES":"[O-][N+](C1=CC=CC=C1OCC(N\/N=C\/C2=CC=C(C3=CC=CC([N+]([O-])=O)=C3)O2)=O)=O",
    "HIT":0.0,
    "question":"Does [O-][N+](C1=CC=CC=C1OCC(N\/N=C\/C2=CC=C(C3=CC=CC([N+]([O-])=O)=C3)O2)=O)=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":68660
  },
  {
    "COADD_ID":"CO-ADD:0242552",
    "INHIB_AVE":-0.98,
    "SMILES":"N1(c2cccc(C)c2)C(=O)NC(\\C(=C\/c3ccccc3OC)\\C1=O)=O",
    "HIT":0.0,
    "question":"Can exposure to N1(c2cccc(C)c2)C(=O)NC(\\C(=C\/c3ccccc3OC)\\C1=O)=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":61063
  },
  {
    "COADD_ID":"CO-ADD:0247342",
    "INHIB_AVE":2.6,
    "SMILES":"c(C#N)(c(\\C(\\C#N)=C\\c1cccc(Cl)c1Cl)nn2c3ccccc3)c2N",
    "HIT":0.0,
    "question":"Does treatment with c(C#N)(c(\\C(\\C#N)=C\\c1cccc(Cl)c1Cl)nn2c3ccccc3)c2N result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":46400
  },
  {
    "COADD_ID":"CO-ADD:0299431",
    "INHIB_AVE":-0.22,
    "SMILES":"N1(c2cccc(OC(C)=O)c2)C(=O)c(c3C1=O)ccc(c3)C(=O)Nc4ccccc4",
    "HIT":0.0,
    "question":"Is N1(c2cccc(OC(C)=O)c2)C(=O)c(c3C1=O)ccc(c3)C(=O)Nc4ccccc4 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":58319
  },
  {
    "COADD_ID":"CO-ADD:0230839",
    "INHIB_AVE":-8.09,
    "SMILES":"N1(C(C)=O)[C@@H](c2ccc(cc2)Br)SC[C@H]1C(O)=O",
    "HIT":0.0,
    "question":"Is N1(C(C)=O)[C@@H](c2ccc(cc2)Br)SC[C@H]1C(O)=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":76833
  },
  {
    "COADD_ID":"CO-ADD:0229675",
    "INHIB_AVE":21.53,
    "SMILES":"S(=O)(=O)(c(cc1)ccc1[N+](=O)[O-])N2CCSC2c3ccc(c(Br)c3)OC",
    "HIT":0.0,
    "question":"Is S(=O)(=O)(c(cc1)ccc1[N+](=O)[O-])N2CCSC2c3ccc(c(Br)c3)OC effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":2112
  },
  {
    "COADD_ID":"CO-ADD:0222572",
    "INHIB_AVE":7.6,
    "SMILES":"c1(c2ccc(cc2)Cl)nc(sc1c(cc3)ccc3[N+](=O)[O-])\\N=C\\c4c(O)ccc(cccc5)c45",
    "HIT":0.0,
    "question":"Does the proposed molecule c1(c2ccc(cc2)Cl)nc(sc1c(cc3)ccc3[N+](=O)[O-])\\N=C\\c4c(O)ccc(cccc5)c45 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":24694
  },
  {
    "COADD_ID":"CO-ADD:0220857",
    "INHIB_AVE":-4.85,
    "SMILES":"C(OCCCCCCCCCC)(=O)c1ccc(cc1)NC(CCCCCCCCC)=O",
    "HIT":0.0,
    "question":"Can C(OCCCCCCCCCC)(=O)c1ccc(cc1)NC(CCCCCCCCC)=O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":71553
  },
  {
    "COADD_ID":"CO-ADD:0137708",
    "INHIB_AVE":6.91,
    "SMILES":"c(c(nc(NCc(cccc1OC)c1)o2)n2)(c3N)non3",
    "HIT":0.0,
    "question":"Does the proposed molecule c(c(nc(NCc(cccc1OC)c1)o2)n2)(c3N)non3 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":27370
  },
  {
    "COADD_ID":"CO-ADD:0255976",
    "INHIB_AVE":-25.81,
    "SMILES":"C(=O)(N\\N=C\\c1cc(Cl)ccc1O)c2cccc(F)c2",
    "HIT":0.0,
    "question":"Does C(=O)(N\\N=C\\c1cc(Cl)ccc1O)c2cccc(F)c2 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":82487
  },
  {
    "COADD_ID":"CO-ADD:0220452",
    "INHIB_AVE":6.34,
    "SMILES":"C(=O)(C(c1ccccc1)c2ccccc2)NCC(=O)N\\N=C\\c3ccccc3Cl",
    "HIT":0.0,
    "question":"Is C(=O)(C(c1ccccc1)c2ccccc2)NCC(=O)N\\N=C\\c3ccccc3Cl effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":29824
  },
  {
    "COADD_ID":"CO-ADD:0290316",
    "INHIB_AVE":94.15,
    "SMILES":"C(C(OCC)=O)(=CN(CC)c1c2cc(c(N(CC3)CCN3C)c1)F)C2=O",
    "HIT":1.0,
    "question":"Can exposure to C(C(OCC)=O)(=CN(CC)c1c2cc(c(N(CC3)CCN3C)c1)F)C2=O lead to reduced viability of E. coli?",
    "answer":"Yes",
    "_id":125
  },
  {
    "COADD_ID":"CO-ADD:0259445",
    "INHIB_AVE":4.58,
    "SMILES":"c12c(nnc(SCC(=O)N(c3c4cccc3)c5c(S4)cccc5)n1)c6c(cccc6)n2CCc7ccccc7",
    "HIT":0.0,
    "question":"Does treatment with c12c(nnc(SCC(=O)N(c3c4cccc3)c5c(S4)cccc5)n1)c6c(cccc6)n2CCc7ccccc7 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":37540
  },
  {
    "COADD_ID":"CO-ADD:0137888",
    "INHIB_AVE":1.99,
    "SMILES":"ClC1=CC=C(C=C1)C2=NOC(CC3=C(OC)C(OCO4)=C4C(OC)=C3)C2",
    "HIT":0.0,
    "question":"Is ClC1=CC=C(C=C1)C2=NOC(CC3=C(OC)C(OCO4)=C4C(OC)=C3)C2 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":49145
  },
  {
    "COADD_ID":"CO-ADD:0320260",
    "INHIB_AVE":-1.68,
    "SMILES":"c1(C(OC)=O)sc2c(c(COC)cc(C)n2)c1NC(=O)c3ccco3",
    "HIT":0.0,
    "question":"Is c1(C(OC)=O)sc2c(c(COC)cc(C)n2)c1NC(=O)c3ccco3 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":63349
  },
  {
    "COADD_ID":"CO-ADD:0242038",
    "INHIB_AVE":1.52,
    "SMILES":"S(=O)(=O)(N(CC)CC)c(cccc1C(=O)Nc2nncs2)c1",
    "HIT":0.0,
    "question":"Does S(=O)(=O)(N(CC)CC)c(cccc1C(=O)Nc2nncs2)c1 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":51207
  },
  {
    "COADD_ID":"CO-ADD:0136403",
    "INHIB_AVE":3.15,
    "SMILES":"n1ccsc1N=Nc2c3c(cccc3)ccc2O",
    "HIT":0.0,
    "question":"Can exposure to n1ccsc1N=Nc2c3c(cccc3)ccc2O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":43956
  },
  {
    "COADD_ID":"CO-ADD:0157862",
    "INHIB_AVE":8.79,
    "SMILES":"[O-][N+](C(C=CC=C1)=C1\/C=N\/C2=CC(N=C(C(C=C3)=CC=C3C(C)(C)C)O4)=C4C=C2)=O",
    "HIT":0.0,
    "question":"Can exposure to [O-][N+](C(C=CC=C1)=C1\/C=N\/C2=CC(N=C(C(C=C3)=CC=C3C(C)(C)C)O4)=C4C=C2)=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":20560
  },
  {
    "COADD_ID":"CO-ADD:0250411",
    "INHIB_AVE":4.73,
    "SMILES":"C(\/S\\C(\\C1=O)=C\/c(ccc2c3ccc(c(Cl)c3)C)o2)(=N\\C(C)=O)\\N1",
    "HIT":0.0,
    "question":"Can C(\/S\\C(\\C1=O)=C\/c(ccc2c3ccc(c(Cl)c3)C)o2)(=N\\C(C)=O)\\N1 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":36881
  },
  {
    "COADD_ID":"CO-ADD:0244522",
    "INHIB_AVE":20.42,
    "SMILES":"C(=O)(c1cccc(c1)NC(Cc2ccccc2)=O)N\\N=C(\/C)\\C",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C(=O)(c1cccc(c1)NC(Cc2ccccc2)=O)N\\N=C(\/C)\\C?",
    "answer":"No",
    "_id":2635
  },
  {
    "COADD_ID":"CO-ADD:0244388",
    "INHIB_AVE":-7.78,
    "SMILES":"N1(c2ccccc2)\\C(=N\\c3ccccc3)\\S\\C(=C\\c(cc4)cc(c4OC(C)=O)OC)\\C1=O",
    "HIT":0.0,
    "question":"Can N1(c2ccccc2)\\C(=N\\c3ccccc3)\\S\\C(=C\\c(cc4)cc(c4OC(C)=O)OC)\\C1=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":76461
  },
  {
    "COADD_ID":"CO-ADD:0299699",
    "INHIB_AVE":9.42,
    "SMILES":"C12(c3c(NC1=O)ccc(Cl)c3)C(C#N)=C(N)Oc([nH]nc4C(C)(C)C)c24",
    "HIT":0.0,
    "question":"Can exposure to C12(c3c(NC1=O)ccc(Cl)c3)C(C#N)=C(N)Oc([nH]nc4C(C)(C)C)c24 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":18674
  },
  {
    "COADD_ID":"CO-ADD:0227979",
    "INHIB_AVE":-4.88,
    "SMILES":"c1(\\C=N\\NC(COc2ccc(cc2OC)Br)=O)c(OCC)ccc(cccc3)c13",
    "HIT":0.0,
    "question":"Does the proposed molecule c1(\\C=N\\NC(COc2ccc(cc2OC)Br)=O)c(OCC)ccc(cccc3)c13 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":71612
  },
  {
    "COADD_ID":"CO-ADD:0161955",
    "INHIB_AVE":7.98,
    "SMILES":"[N+](=O)([O-])c1ccccc1C(=O)Nc(cc2)ccc2NC(=O)c(cc3)ccc3NC(=O)c4ccccc4[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Does treatment with [N+](=O)([O-])c1ccccc1C(=O)Nc(cc2)ccc2NC(=O)c(cc3)ccc3NC(=O)c4ccccc4[N+](=O)[O-] result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":23250
  },
  {
    "COADD_ID":"CO-ADD:0252415",
    "INHIB_AVE":-14.98,
    "SMILES":"S(c1ccccc1)(=O)(=O)N(c(cc2)ccc2[N+](=O)[O-])CC(=O)N\\N=C(\/C)\\C(C)(C)C",
    "HIT":0.0,
    "question":"Does S(c1ccccc1)(=O)(=O)N(c(cc2)ccc2[N+](=O)[O-])CC(=O)N\\N=C(\/C)\\C(C)(C)C demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":81286
  },
  {
    "COADD_ID":"CO-ADD:0283807",
    "INHIB_AVE":-0.24,
    "SMILES":"S(=O)(=O)(N(CC)CC)c(ccc(c1C(=O)Oc(cccc2NC(=O)c3ccco3)c2)Cl)c1",
    "HIT":0.0,
    "question":"Does S(=O)(=O)(N(CC)CC)c(ccc(c1C(=O)Oc(cccc2NC(=O)c3ccco3)c2)Cl)c1 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":58392
  },
  {
    "COADD_ID":"CO-ADD:0222240",
    "INHIB_AVE":1.69,
    "SMILES":"[N+](=O)([O-])c(ccc(c1\\C=N\\NC(COc2cccc(Cl)c2)=O)N3CCCCC3)c1",
    "HIT":0.0,
    "question":"Is [N+](=O)([O-])c(ccc(c1\\C=N\\NC(COc2cccc(Cl)c2)=O)N3CCCCC3)c1 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":50482
  },
  {
    "COADD_ID":"CO-ADD:0227713",
    "INHIB_AVE":16.24,
    "SMILES":"C(\/CC1CC)(=C\/c(cc2)ccc2OC)\\C(=O)\\C(\\C1)=C\\c(cc3)ccc3OC",
    "HIT":0.0,
    "question":"Can exposure to C(\/CC1CC)(=C\/c(cc2)ccc2OC)\\C(=O)\\C(\\C1)=C\\c(cc3)ccc3OC lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":6069
  },
  {
    "COADD_ID":"CO-ADD:0162623",
    "INHIB_AVE":11.46,
    "SMILES":"c1(C#N)c(c2cccs2)c3c(nc1SCC(OCc4ccccc4)=O)CCC3",
    "HIT":0.0,
    "question":"Does the proposed molecule c1(C#N)c(c2cccs2)c3c(nc1SCC(OCc4ccccc4)=O)CCC3 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":13546
  },
  {
    "COADD_ID":"CO-ADD:0278243",
    "INHIB_AVE":-5.94,
    "SMILES":"C12=C(CC(C)(C)CC1=O)c3c(ccc(cccc4)c34)NC2c5ccc(c(cc6)cc(c67)COC7=O)o5",
    "HIT":0.0,
    "question":"Can C12=C(CC(C)(C)CC1=O)c3c(ccc(cccc4)c34)NC2c5ccc(c(cc6)cc(c67)COC7=O)o5 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":73608
  },
  {
    "COADD_ID":"CO-ADD:0228665",
    "INHIB_AVE":14.12,
    "SMILES":"c12c(CC(C)(C)CC1=O)oc(cc(OC(C)=O)c(OC(C)=O)c3)c23",
    "HIT":0.0,
    "question":"Can c12c(CC(C)(C)CC1=O)oc(cc(OC(C)=O)c(OC(C)=O)c3)c23 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":8845
  },
  {
    "COADD_ID":"CO-ADD:0284163",
    "INHIB_AVE":14.4,
    "SMILES":"N1(c2cccc(Br)c2)C(=O)\\C(\\C=C1c3ccccc3)=C\\c(ccc4c(ccc(c5Cl)Cl)c5)o4",
    "HIT":0.0,
    "question":"Does N1(c2cccc(Br)c2)C(=O)\\C(\\C=C1c3ccccc3)=C\\c(ccc4c(ccc(c5Cl)Cl)c5)o4 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":8403
  },
  {
    "COADD_ID":"CO-ADD:0249674",
    "INHIB_AVE":2.64,
    "SMILES":"c1(c2ccc(cc2)Cl)ccc(\\C=N\\NC(=O)Nc3ccccc3)o1",
    "HIT":0.0,
    "question":"Does c1(c2ccc(cc2)Cl)ccc(\\C=N\\NC(=O)Nc3ccccc3)o1 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":46230
  },
  {
    "COADD_ID":"CO-ADD:0293842",
    "INHIB_AVE":-0.37,
    "SMILES":"[N+](=O)([O-])c(cc1)cc(c1C(N)=O)SCc2ccccc2",
    "HIT":0.0,
    "question":"Can exposure to [N+](=O)([O-])c(cc1)cc(c1C(N)=O)SCc2ccccc2 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":58880
  },
  {
    "COADD_ID":"CO-ADD:0244241",
    "INHIB_AVE":1.51,
    "SMILES":"N1(C(=O)c2ccc(cc2)Cl)C(O)(c(cc3)ccn3)CC(C(F)(F)F)=N1",
    "HIT":0.0,
    "question":"Is N1(C(=O)c2ccc(cc2)Cl)C(O)(c(cc3)ccn3)CC(C(F)(F)F)=N1 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":51230
  },
  {
    "COADD_ID":"CO-ADD:0284715",
    "INHIB_AVE":16.91,
    "SMILES":"N1(C(c2ccc(cc2)Br)CC(c3ccc(cc3)C)=N1)C(=N)SC(CC(N4c5ccc(cc5)Br)=O)C4=O",
    "HIT":0.0,
    "question":"Can exposure to N1(C(c2ccc(cc2)Br)CC(c3ccc(cc3)C)=N1)C(=N)SC(CC(N4c5ccc(cc5)Br)=O)C4=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":5372
  },
  {
    "COADD_ID":"CO-ADD:0295166",
    "INHIB_AVE":3.37,
    "SMILES":"c1(C(OC)=O)n[nH]cc1N",
    "HIT":0.0,
    "question":"Does treatment with c1(C(OC)=O)n[nH]cc1N result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":42950
  },
  {
    "COADD_ID":"CO-ADD:0235751",
    "INHIB_AVE":-1.17,
    "SMILES":"C(C#N)(C1c2ccc(c3c2)OCO3)=C(N)N(C(CC(C)(C)CC4=O)=C14)c5cccc(c5)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Does C(C#N)(C1c2ccc(c3c2)OCO3)=C(N)N(C(CC(C)(C)CC4=O)=C14)c5cccc(c5)[N+](=O)[O-] demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":61653
  },
  {
    "COADD_ID":"CO-ADD:0277500",
    "INHIB_AVE":4.68,
    "SMILES":"C(C(=O)OC(C)C)(C(c(cc1)cc(c1OC(F)F)OC)N2)=C(C)N(C2=O)C",
    "HIT":0.0,
    "question":"Does treatment with C(C(=O)OC(C)C)(C(c(cc1)cc(c1OC(F)F)OC)N2)=C(C)N(C2=O)C result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":37091
  },
  {
    "COADD_ID":"CO-ADD:0245306",
    "INHIB_AVE":10.83,
    "SMILES":"N1(c2cccc(c2)C(O)=O)C(=O)C3C(C1=O)C(C(=O)C34c5ccccc5)(c6ccccc6)C(=C4c7ccc(c8c7)OCO8)c9ccc(c%10c9)OCO%10",
    "HIT":0.0,
    "question":"Does N1(c2cccc(c2)C(O)=O)C(=O)C3C(C1=O)C(C(=O)C34c5ccccc5)(c6ccccc6)C(=C4c7ccc(c8c7)OCO8)c9ccc(c%10c9)OCO%10 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":14921
  },
  {
    "COADD_ID":"CO-ADD:0236644",
    "INHIB_AVE":11.77,
    "SMILES":"C1(C#N)(C#N)C(c2ccccc2)C(C3)C(C(C#N)=C1N)=CCN3.C(=O)O",
    "HIT":0.0,
    "question":"Can exposure to C1(C#N)(C#N)C(c2ccccc2)C(C3)C(C(C#N)=C1N)=CCN3.C(=O)O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":12895
  },
  {
    "COADD_ID":"CO-ADD:0221671",
    "INHIB_AVE":1.6,
    "SMILES":"c(cc(C)c(c1[N+](=O)[O-])C)([N+](=O)[O-])c1NC(CC)CC",
    "HIT":0.0,
    "question":"Does c(cc(C)c(c1[N+](=O)[O-])C)([N+](=O)[O-])c1NC(CC)CC show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":50850
  },
  {
    "COADD_ID":"CO-ADD:0230127",
    "INHIB_AVE":3.52,
    "SMILES":"S(Cc1ccccc1)(=O)(=O)N\\N=C(\/C)\\c(cc2)ccc2NC(=O)c3ccc(c(OC)c3)OC",
    "HIT":0.0,
    "question":"Can exposure to S(Cc1ccccc1)(=O)(=O)N\\N=C(\/C)\\c(cc2)ccc2NC(=O)c3ccc(c(OC)c3)OC lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":42306
  },
  {
    "COADD_ID":"CO-ADD:0162755",
    "INHIB_AVE":-7.61,
    "SMILES":"N(=C\\c1ccccc1Br)\/NC(CCCc2ccccc2)=O",
    "HIT":0.0,
    "question":"Does treatment with N(=C\\c1ccccc1Br)\/NC(CCCc2ccccc2)=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":76222
  },
  {
    "COADD_ID":"CO-ADD:0241792",
    "INHIB_AVE":16.26,
    "SMILES":"C(C(=O)OCc1ccccc1)(=C(C)OC(=C2C#N)N)C2c(cc3)ccc3C(F)(F)F",
    "HIT":0.0,
    "question":"Does the proposed molecule C(C(=O)OCc1ccccc1)(=C(C)OC(=C2C#N)N)C2c(cc3)ccc3C(F)(F)F exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":6040
  },
  {
    "COADD_ID":"CO-ADD:0277391",
    "INHIB_AVE":7.31,
    "SMILES":"C(=N\\c1ccccc1)(\/S\\C(\\C2=O)=C\\c(cc3)ccc3OCc(cc4)ccc4F)\\N2C5CCCCC5",
    "HIT":0.0,
    "question":"Is C(=N\\c1ccccc1)(\/S\\C(\\C2=O)=C\\c(cc3)ccc3OCc(cc4)ccc4F)\\N2C5CCCCC5 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":25803
  },
  {
    "COADD_ID":"CO-ADD:0156471",
    "INHIB_AVE":2.35,
    "SMILES":"O=C(C1=CC=C(Cl)C=C1)NC2=CC=C3OC(C4=C(Cl)C=C(F)C=C4)=NC3=C2",
    "HIT":0.0,
    "question":"Does O=C(C1=CC=C(Cl)C=C1)NC2=CC=C3OC(C4=C(Cl)C=C(F)C=C4)=NC3=C2 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":47540
  },
  {
    "COADD_ID":"CO-ADD:0218118",
    "INHIB_AVE":21.85,
    "SMILES":"c1(c(Cl)c2c(cccc2)s1)C(=O)N3CCCc(cccc4)c34",
    "HIT":0.0,
    "question":"Does c1(c(Cl)c2c(cccc2)s1)C(=O)N3CCCc(cccc4)c34 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":1981
  },
  {
    "COADD_ID":"CO-ADD:0291890",
    "INHIB_AVE":-8.34,
    "SMILES":"c1(c2ccc(OCC(=O)Nc(cccc3C(OCCCC)=O)c3)c1)OC(C=C2C)=O",
    "HIT":0.0,
    "question":"Can exposure to c1(c2ccc(OCC(=O)Nc(cccc3C(OCCCC)=O)c3)c1)OC(C=C2C)=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":77126
  },
  {
    "COADD_ID":"CO-ADD:0229750",
    "INHIB_AVE":10.15,
    "SMILES":"N1(c2cccc(c2)C(=O)NC(=CNC(N3)=O)C3=O)C(=O)c(c4C1=O)ccc(c4)C(=O)NC(=CNC(N5)=O)C5=O",
    "HIT":0.0,
    "question":"Can exposure to N1(c2cccc(c2)C(=O)NC(=CNC(N3)=O)C3=O)C(=O)c(c4C1=O)ccc(c4)C(=O)NC(=CNC(N5)=O)C5=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":16615
  },
  {
    "COADD_ID":"CO-ADD:0149195",
    "INHIB_AVE":11.17,
    "SMILES":"c(OC)(c(OC)c1C(=O)O)c(OC2)c(O2)c1",
    "HIT":0.0,
    "question":"Does c(OC)(c(OC)c1C(=O)O)c(OC2)c(O2)c1 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":14161
  },
  {
    "COADD_ID":"CO-ADD:0299560",
    "INHIB_AVE":13.03,
    "SMILES":"C(=O)(CN(CC1)CCO1)N\\N=C\\c(ccc(c23)OCO2)c3",
    "HIT":0.0,
    "question":"Can exposure to C(=O)(CN(CC1)CCO1)N\\N=C\\c(ccc(c23)OCO2)c3 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":10512
  },
  {
    "COADD_ID":"CO-ADD:0326748",
    "INHIB_AVE":-1.04,
    "SMILES":"C1(c2csc(\\C(\\C#N)=C\\c3ccco3)n2)=C(C)N(N(c4ccccc4)C1=O)C",
    "HIT":0.0,
    "question":"Is C1(c2csc(\\C(\\C#N)=C\\c3ccco3)n2)=C(C)N(N(c4ccccc4)C1=O)C capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":61239
  },
  {
    "COADD_ID":"CO-ADD:0320426",
    "INHIB_AVE":-1.82,
    "SMILES":"c1(N(CC2)CCN2c3cccc(Cl)c3)nc(Nc(cc4)ccc4OC(F)(F)F)nc(N(C)C)n1",
    "HIT":0.0,
    "question":"Is c1(N(CC2)CCN2c3cccc(Cl)c3)nc(Nc(cc4)ccc4OC(F)(F)F)nc(N(C)C)n1 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":63809
  },
  {
    "COADD_ID":"CO-ADD:0292086",
    "INHIB_AVE":4.53,
    "SMILES":"S(=O)(=O)(c1ccc(cc1)N=NN(C)C)NC(Cc2ccccc2)=O",
    "HIT":0.0,
    "question":"Is S(=O)(=O)(c1ccc(cc1)N=NN(C)C)NC(Cc2ccccc2)=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":37783
  },
  {
    "COADD_ID":"CO-ADD:0279151",
    "INHIB_AVE":5.24,
    "SMILES":"C(=N\/c1ccccc1)(\/S\\C(\\C2=O)=C\\c(ccc(c3OC)OCc4ccccc4F)c3)\\N2",
    "HIT":0.0,
    "question":"Does the proposed molecule C(=N\/c1ccccc1)(\/S\\C(\\C2=O)=C\\c(ccc(c3OC)OCc4ccccc4F)c3)\\N2 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":34575
  },
  {
    "COADD_ID":"CO-ADD:0155608",
    "INHIB_AVE":-12.89,
    "SMILES":"O=C(C(C=C1)=CC=C1NC(C(C=C2)=CC=C2NC(CCCCCCC)=O)=O)NC(C(C)=C3)=CC=C3Cl",
    "HIT":0.0,
    "question":"Does treatment with O=C(C(C=C1)=CC=C1NC(C(C=C2)=CC=C2NC(CCCCCCC)=O)=O)NC(C(C)=C3)=CC=C3Cl result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":80479
  },
  {
    "COADD_ID":"CO-ADD:0303770",
    "INHIB_AVE":3.33,
    "SMILES":"c1(sc(c2n1)CCCC2)\\C(\\C#N)=C\\c(ccc(c3OCc4ccccc4)OC)c3",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(sc(c2n1)CCCC2)\\C(\\C#N)=C\\c(ccc(c3OCc4ccccc4)OC)c3?",
    "answer":"No",
    "_id":43120
  },
  {
    "COADD_ID":"CO-ADD:0259281",
    "INHIB_AVE":5.7,
    "SMILES":"n1(nnc(C(=O)N\\N=C\\c2ccccc2Cl)c1CSc3oc(c4n3)cccc4)c5nonc5N",
    "HIT":0.0,
    "question":"Does treatment with n1(nnc(C(=O)N\\N=C\\c2ccccc2Cl)c1CSc3oc(c4n3)cccc4)c5nonc5N result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":32509
  },
  {
    "COADD_ID":"CO-ADD:0237124",
    "INHIB_AVE":3.4,
    "SMILES":"Cc1onc(C)c1C(=O)N2CCCC(C2)c3[nH]c4c(C)cccc4c3c5ccncc5",
    "HIT":0.0,
    "question":"Can exposure to Cc1onc(C)c1C(=O)N2CCCC(C2)c3[nH]c4c(C)cccc4c3c5ccncc5 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":42845
  },
  {
    "COADD_ID":"CO-ADD:0162760",
    "INHIB_AVE":2.0,
    "SMILES":"C(=O)(Nc(cc1)ccc1I)Nc(cc2)ccc2OCCCCCCCCCC",
    "HIT":0.0,
    "question":"Does the proposed molecule C(=O)(Nc(cc1)ccc1I)Nc(cc2)ccc2OCCCCCCCCCC exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":49102
  },
  {
    "COADD_ID":"CO-ADD:0278297",
    "INHIB_AVE":-9.14,
    "SMILES":"N(CN(CC1)CCO1)(N=C(N2c3ccccc3)Cc4ccccc4)C2=S",
    "HIT":0.0,
    "question":"Is N(CN(CC1)CCO1)(N=C(N2c3ccccc3)Cc4ccccc4)C2=S effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":77995
  },
  {
    "COADD_ID":"CO-ADD:0306352",
    "INHIB_AVE":0.06,
    "SMILES":"N1(\\N=C\\c2ccccc2)c(cccc3)c3C(c4ccc(cc4)C)(c5ccc(cc5)C)C1=O",
    "HIT":0.0,
    "question":"Can exposure to N1(\\N=C\\c2ccccc2)c(cccc3)c3C(c4ccc(cc4)C)(c5ccc(cc5)C)C1=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":57226
  },
  {
    "COADD_ID":"CO-ADD:0259681",
    "INHIB_AVE":7.29,
    "SMILES":"c1(SCC(=O)N\\N=C(\/C2)\\CCC2)nc(C)cc(C)n1",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(SCC(=O)N\\N=C(\/C2)\\CCC2)nc(C)cc(C)n1?",
    "answer":"No",
    "_id":25897
  },
  {
    "COADD_ID":"CO-ADD:0223115",
    "INHIB_AVE":2.73,
    "SMILES":"c(\\C=N\\NC(COc(cc1)ccc1Cl)=O)(cc(OCO2)c2c3)c3Cl",
    "HIT":0.0,
    "question":"Does treatment with c(\\C=N\\NC(COc(cc1)ccc1Cl)=O)(cc(OCO2)c2c3)c3Cl result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":45867
  },
  {
    "COADD_ID":"CO-ADD:0157364",
    "INHIB_AVE":3.67,
    "SMILES":"O=C(COC(C=CC=C1)=C1OC)N\/N=C\/C2=C(OCC)C=CC(Br)=C2",
    "HIT":0.0,
    "question":"Can exposure to O=C(COC(C=CC=C1)=C1OC)N\/N=C\/C2=C(OCC)C=CC(Br)=C2 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":41623
  },
  {
    "COADD_ID":"CO-ADD:0290518",
    "INHIB_AVE":9.45,
    "SMILES":"N1(CN(CC2)CCC23OCCO3)N=C(N(C)C1=S)COc(ccc(c4C)C)c4",
    "HIT":0.0,
    "question":"Is N1(CN(CC2)CCC23OCCO3)N=C(N(C)C1=S)COc(ccc(c4C)C)c4 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":18596
  },
  {
    "COADD_ID":"CO-ADD:0257036",
    "INHIB_AVE":-9.33,
    "SMILES":"n12c(NC(C)=CC1=O)cc(c3cccc(Br)c3)n2",
    "HIT":0.0,
    "question":"Does n12c(NC(C)=CC1=O)cc(c3cccc(Br)c3)n2 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":78183
  },
  {
    "COADD_ID":"CO-ADD:0286119",
    "INHIB_AVE":-8.24,
    "SMILES":"c1(c2c(sc1NC(=O)c3ccc(cc3)C)CCCC2)C(=O)Nc4cccc(cccc5)c45",
    "HIT":0.0,
    "question":"Does c1(c2c(sc1NC(=O)c3ccc(cc3)C)CCCC2)C(=O)Nc4cccc(cccc5)c45 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":76999
  },
  {
    "COADD_ID":"CO-ADD:0311777",
    "INHIB_AVE":-0.04,
    "SMILES":"N(c1ccc(cc1C)Br)(C(c2ccccc2)=O)NC(=O)C(O)(c3ccc(cc3)Cl)c4ccc(cc4)Cl",
    "HIT":0.0,
    "question":"Does the proposed molecule N(c1ccc(cc1C)Br)(C(c2ccccc2)=O)NC(=O)C(O)(c3ccc(cc3)Cl)c4ccc(cc4)Cl exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":57660
  },
  {
    "COADD_ID":"CO-ADD:0321000",
    "INHIB_AVE":2.03,
    "SMILES":"N1(CCc(cc2)ccc2F)C(=O)NC(C([S+](C)C)=C1[O-])=O",
    "HIT":0.0,
    "question":"Can N1(CCc(cc2)ccc2F)C(=O)NC(C([S+](C)C)=C1[O-])=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":48947
  },
  {
    "COADD_ID":"CO-ADD:0156630",
    "INHIB_AVE":8.15,
    "SMILES":"OC([C@@H](NC(C1=CC=CC(C(F)(F)F)=C1)=O)C(C)C)=O",
    "HIT":0.0,
    "question":"Does treatment with OC([C@@H](NC(C1=CC=CC(C(F)(F)F)=C1)=O)C(C)C)=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":22661
  },
  {
    "COADD_ID":"CO-ADD:0305967",
    "INHIB_AVE":3.27,
    "SMILES":"n1c(c(cc2)ccc2c3ccccc3)csc1Cc4csc(c5ccc(cc5)Br)n4",
    "HIT":0.0,
    "question":"Does the proposed molecule n1c(c(cc2)ccc2c3ccccc3)csc1Cc4csc(c5ccc(cc5)Br)n4 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":43394
  },
  {
    "COADD_ID":"CO-ADD:0217306",
    "INHIB_AVE":7.23,
    "SMILES":"n1c(ccc(c2)\\N=C\\c(c3)c(O)c(cc3[N+](=O)[O-])Br)c2oc1c4ccc(cc4)Cl",
    "HIT":0.0,
    "question":"Is n1c(ccc(c2)\\N=C\\c(c3)c(O)c(cc3[N+](=O)[O-])Br)c2oc1c4ccc(cc4)Cl effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":26125
  },
  {
    "COADD_ID":"CO-ADD:0218909",
    "INHIB_AVE":16.73,
    "SMILES":"C(=O)(NC(C)CC)C\\C(\\C)=N\/NC(COc1ccccc1)=O",
    "HIT":0.0,
    "question":"Can C(=O)(NC(C)CC)C\\C(\\C)=N\/NC(COc1ccccc1)=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":5552
  },
  {
    "COADD_ID":"CO-ADD:0218059",
    "INHIB_AVE":0.35,
    "SMILES":"C(=C\\c(ccc1c2ccc(cc2)Br)o1)(\/C(=O)N(C)C(N3C)=O)\\C3=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C(=C\\c(ccc1c2ccc(cc2)Br)o1)(\/C(=O)N(C)C(N3C)=O)\\C3=O?",
    "answer":"No",
    "_id":56068
  },
  {
    "COADD_ID":"CO-ADD:0294317",
    "INHIB_AVE":-6.24,
    "SMILES":"C12=C(CC(c3ccc(c(OC)c3)OC)CC1=O)Nc(c4NC2c(cc5)ccn5)cccc4",
    "HIT":0.0,
    "question":"Can C12=C(CC(c3ccc(c(OC)c3)OC)CC1=O)Nc(c4NC2c(cc5)ccn5)cccc4 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":74150
  },
  {
    "COADD_ID":"CO-ADD:0295675",
    "INHIB_AVE":13.41,
    "SMILES":"C(C(c1ccccc1)=O)(C2c(cc3)ccc3N(C)C)=C(O)C(N2CCCC(O)=O)=O",
    "HIT":0.0,
    "question":"Does C(C(c1ccccc1)=O)(C2c(cc3)ccc3N(C)C)=C(O)C(N2CCCC(O)=O)=O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":9908
  },
  {
    "COADD_ID":"CO-ADD:0331663",
    "INHIB_AVE":4.2,
    "SMILES":"c1(c(C)n[nH]c1O)C(c(cc2OCC)cc(c2OC)Br)c3c(C)n[nH]c3O",
    "HIT":0.0,
    "question":"Is c1(c(C)n[nH]c1O)C(c(cc2OCC)cc(c2OC)Br)c3c(C)n[nH]c3O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":39252
  },
  {
    "COADD_ID":"CO-ADD:0162939",
    "INHIB_AVE":8.09,
    "SMILES":"C(=O)(N\\N=C\\c(cc1)ccc1OCc2ccccc2)C(NCCC)=O",
    "HIT":0.0,
    "question":"Can C(=O)(N\\N=C\\c(cc1)ccc1OCc2ccccc2)C(NCCC)=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":22898
  },
  {
    "COADD_ID":"CO-ADD:0259182",
    "INHIB_AVE":7.24,
    "SMILES":"C1(C)(C(OCC)=O)C=C(C(=O)N1c2ccccc2)Nc(cc3)ccc3C(OCC)=O",
    "HIT":0.0,
    "question":"Does treatment with C1(C)(C(OCC)=O)C=C(C(=O)N1c2ccccc2)Nc(cc3)ccc3C(OCC)=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":26073
  },
  {
    "COADD_ID":"CO-ADD:0256698",
    "INHIB_AVE":-4.14,
    "SMILES":"n1c(c2ccc(cc2)OC)[nH]c(c3ccccc3)c1c(ccc(c45)c(c6C4=O)cccc6)c5",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound n1c(c2ccc(cc2)OC)[nH]c(c3ccccc3)c1c(ccc(c45)c(c6C4=O)cccc6)c5?",
    "answer":"No",
    "_id":70073
  },
  {
    "COADD_ID":"CO-ADD:0293517",
    "INHIB_AVE":1.85,
    "SMILES":"c1(C2c3ccc(c(OCC)c3)OC)c([nH]nc1C(C)(C)C)OC(N)=C2C#N",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(C2c3ccc(c(OCC)c3)OC)c([nH]nc1C(C)(C)C)OC(N)=C2C#N?",
    "answer":"No",
    "_id":49761
  },
  {
    "COADD_ID":"CO-ADD:0320852",
    "INHIB_AVE":4.24,
    "SMILES":"[N+](=O)([O-])c(cc1)cc(c1C(OC)=O)N",
    "HIT":0.0,
    "question":"Does [N+](=O)([O-])c(cc1)cc(c1C(OC)=O)N show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":39086
  },
  {
    "COADD_ID":"CO-ADD:0257106",
    "INHIB_AVE":1.03,
    "SMILES":"S(=O)(=O)(c1ccc(cc1)OCC)N(c2ccc(cc2)C)CC(=O)N\\N=C(\\CC3)\/CCN3C",
    "HIT":0.0,
    "question":"Can exposure to S(=O)(=O)(c1ccc(cc1)OCC)N(c2ccc(cc2)C)CC(=O)N\\N=C(\\CC3)\/CCN3C lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":53329
  },
  {
    "COADD_ID":"CO-ADD:0278433",
    "INHIB_AVE":-5.8,
    "SMILES":"c1(c2ccc(cc2)NC(CSc3nncn3C)=O)[nH]c4c(ccc(c4)NC(CSc5nncn5C)=O)n1",
    "HIT":0.0,
    "question":"Can c1(c2ccc(cc2)NC(CSc3nncn3C)=O)[nH]c4c(ccc(c4)NC(CSc5nncn5C)=O)n1 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":73359
  },
  {
    "COADD_ID":"CO-ADD:0285439",
    "INHIB_AVE":0.49,
    "SMILES":"c(C(=O)Nc1c(Cl)ccc(Cl)c1)(n(C)nc2C(=O)Nc3c(Cl)ccc(Cl)c3)c2",
    "HIT":0.0,
    "question":"Does c(C(=O)Nc1c(Cl)ccc(Cl)c1)(n(C)nc2C(=O)Nc3c(Cl)ccc(Cl)c3)c2 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":55522
  },
  {
    "COADD_ID":"CO-ADD:0222048",
    "INHIB_AVE":5.1,
    "SMILES":"c1(c2)c(cc(OC)c2NC(=O)c3ccc(cc3)Br)c4c(cccc4)o1",
    "HIT":0.0,
    "question":"Is c1(c2)c(cc(OC)c2NC(=O)c3ccc(cc3)Br)c4c(cccc4)o1 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":35189
  },
  {
    "COADD_ID":"CO-ADD:0257769",
    "INHIB_AVE":0.68,
    "SMILES":"N1(Cc2ccccc2)\\C(=N\/Cc3ccccc3)\\S\\C(=C\\c(ccc(c4OC)O)c4)\\C1=O",
    "HIT":0.0,
    "question":"Is N1(Cc2ccccc2)\\C(=N\/Cc3ccccc3)\\S\\C(=C\\c(ccc(c4OC)O)c4)\\C1=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":54795
  },
  {
    "COADD_ID":"CO-ADD:0253511",
    "INHIB_AVE":1.25,
    "SMILES":"N12C(C)(C3C(C)(C)N1)C(OC2=O)(C)CC3",
    "HIT":0.0,
    "question":"Can N12C(C)(C3C(C)(C)N1)C(OC2=O)(C)CC3 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":52369
  },
  {
    "COADD_ID":"CO-ADD:0291406",
    "INHIB_AVE":-4.22,
    "SMILES":"n1(cnc(cc(C)c(C)c2)c12)C(=O)c3ccco3",
    "HIT":0.0,
    "question":"Is n1(cnc(cc(C)c(C)c2)c12)C(=O)c3ccco3 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":70253
  },
  {
    "COADD_ID":"CO-ADD:0324047",
    "INHIB_AVE":-3.31,
    "SMILES":"c1(c(F)cc(c(Cl)c1)C#N)N(CC2)CCN2C(=O)c3ccc(cc3)F",
    "HIT":0.0,
    "question":"Can exposure to c1(c(F)cc(c(Cl)c1)C#N)N(CC2)CCN2C(=O)c3ccc(cc3)F lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":68034
  },
  {
    "COADD_ID":"CO-ADD:0154989",
    "INHIB_AVE":-0.79,
    "SMILES":"N#CC(C(C(F)(F)F)=C1)=C(SCC=C)N=C1C2=CC=CS2",
    "HIT":0.0,
    "question":"Can exposure to N#CC(C(C(F)(F)F)=C1)=C(SCC=C)N=C1C2=CC=CS2 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":60391
  },
  {
    "COADD_ID":"CO-ADD:0135729",
    "INHIB_AVE":4.03,
    "SMILES":"n1c(N)nc(N2CCOCC2)nc1",
    "HIT":0.0,
    "question":"Does n1c(N)nc(N2CCOCC2)nc1 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":40027
  },
  {
    "COADD_ID":"CO-ADD:0299497",
    "INHIB_AVE":5.98,
    "SMILES":"N1(c2cccc(Cl)c2)C(=O)C=CC(=O)N1",
    "HIT":0.0,
    "question":"Does N1(c2cccc(Cl)c2)C(=O)C=CC(=O)N1 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":31345
  },
  {
    "COADD_ID":"CO-ADD:0237427",
    "INHIB_AVE":1.39,
    "SMILES":"CC(=O)N1CCN(CC1)c1ccc(Oc2ccc(Cl)cc2O)cc1",
    "HIT":0.0,
    "question":"Does treatment with CC(=O)N1CCN(CC1)c1ccc(Oc2ccc(Cl)cc2O)cc1 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":51769
  },
  {
    "COADD_ID":"CO-ADD:0230019",
    "INHIB_AVE":2.73,
    "SMILES":"C(CCCNc1cccc(C)c1)(OCC)=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C(CCCNc1cccc(C)c1)(OCC)=O?",
    "answer":"No",
    "_id":45870
  },
  {
    "COADD_ID":"CO-ADD:0256484",
    "INHIB_AVE":18.75,
    "SMILES":"c1(N(C)C)nc(SC)nc(NCCNS(=O)(=O)c2ccc(cc2)Cl)n1",
    "HIT":0.0,
    "question":"Can c1(N(C)C)nc(SC)nc(NCCNS(=O)(=O)c2ccc(cc2)Cl)n1 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":3712
  },
  {
    "COADD_ID":"CO-ADD:0255379",
    "INHIB_AVE":4.74,
    "SMILES":"N1(C2c3ccc(c4c3)OCO4)C(S\\C(=C\\c(cc5)ccc5OCc6ccc(cc6Cl)Cl)\\C1=O)=NC(C)=C2C(OCC)=O",
    "HIT":0.0,
    "question":"Does N1(C2c3ccc(c4c3)OCO4)C(S\\C(=C\\c(cc5)ccc5OCc6ccc(cc6Cl)Cl)\\C1=O)=NC(C)=C2C(OCC)=O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":36822
  },
  {
    "COADD_ID":"CO-ADD:0310894",
    "INHIB_AVE":8.5,
    "SMILES":"S(=O)(=O)(c1ccc(cc1)NC(C)=O)N(CC2)CCN2c3ccc(cc3[N+](=O)[O-])C(F)(F)F",
    "HIT":0.0,
    "question":"Is S(=O)(=O)(c1ccc(cc1)NC(C)=O)N(CC2)CCN2c3ccc(cc3[N+](=O)[O-])C(F)(F)F capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":21478
  },
  {
    "COADD_ID":"CO-ADD:0332534",
    "INHIB_AVE":15.49,
    "SMILES":"[N+](=O)([O-])c1ccc(cc1NC(C)c2ccccc2)N(CC3)CCN3C(=O)c4ccccc4C",
    "HIT":0.0,
    "question":"Can [N+](=O)([O-])c1ccc(cc1NC(C)c2ccccc2)N(CC3)CCN3C(=O)c4ccccc4C act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":6963
  },
  {
    "COADD_ID":"CO-ADD:0328903",
    "INHIB_AVE":12.51,
    "SMILES":"c12c(C(N(C)C(=O)N1C)=O)n(c(Oc(cc3)ccc3F)n2)Cc(ccc(c4OCC)OCC)c4",
    "HIT":0.0,
    "question":"Can c12c(C(N(C)C(=O)N1C)=O)n(c(Oc(cc3)ccc3F)n2)Cc(ccc(c4OCC)OCC)c4 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":11450
  },
  {
    "COADD_ID":"CO-ADD:0231130",
    "INHIB_AVE":3.73,
    "SMILES":"C(=O)(C\\C(\\C)=N\/NC(COc1ccc(cc1Br)C)=O)Nc2c(C)ccc(Cl)c2",
    "HIT":0.0,
    "question":"Does the proposed molecule C(=O)(C\\C(\\C)=N\/NC(COc1ccc(cc1Br)C)=O)Nc2c(C)ccc(Cl)c2 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":41370
  },
  {
    "COADD_ID":"CO-ADD:0277842",
    "INHIB_AVE":-15.35,
    "SMILES":"C(C#N)(C(c1ccc(cc1)O)CC(N2)=O)=C2SCC(OCc3ccccc3)=O",
    "HIT":0.0,
    "question":"Does treatment with C(C#N)(C(c1ccc(cc1)O)CC(N2)=O)=C2SCC(OCc3ccccc3)=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":81402
  },
  {
    "COADD_ID":"CO-ADD:0155348",
    "INHIB_AVE":0.19,
    "SMILES":"O=C(C1=CC=CC=C1)NC2=CC=CC=C2C(NCCCCCC)=O",
    "HIT":0.0,
    "question":"Does treatment with O=C(C1=CC=CC=C1)NC2=CC=CC=C2C(NCCCCCC)=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":56724
  },
  {
    "COADD_ID":"CO-ADD:0303236",
    "INHIB_AVE":12.16,
    "SMILES":"c1(NC(=O)c2cccc(Cl)c2)sc(c(C)c1C(OCC)=O)C(=O)Nc(c(Cl)ccc3C(F)(F)F)c3",
    "HIT":0.0,
    "question":"Is c1(NC(=O)c2cccc(Cl)c2)sc(c(C)c1C(OCC)=O)C(=O)Nc(c(Cl)ccc3C(F)(F)F)c3 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":12137
  },
  {
    "COADD_ID":"CO-ADD:0231560",
    "INHIB_AVE":-0.53,
    "SMILES":"C(=C\/c(ccc(c1[N+](=O)[O-])Br)c1)(\/C(=O)NN2c3ccc(c(C)c3)C)\\C2=O",
    "HIT":0.0,
    "question":"Is C(=C\/c(ccc(c1[N+](=O)[O-])Br)c1)(\/C(=O)NN2c3ccc(c(C)c3)C)\\C2=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":59474
  },
  {
    "COADD_ID":"CO-ADD:0252614",
    "INHIB_AVE":1.04,
    "SMILES":"C(=O)(N(CC1)CCO1)C(Br)C(Br)c2ccc(cc2)C#N",
    "HIT":0.0,
    "question":"Does the proposed molecule C(=O)(N(CC1)CCO1)C(Br)C(Br)c2ccc(cc2)C#N exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":53261
  },
  {
    "COADD_ID":"CO-ADD:0158541",
    "INHIB_AVE":3.66,
    "SMILES":"FC(C(F)(F)C(F)(F)C(F)1F)(F)C(C(NC2=CC(C(F)(F)F)=CC=C2Cl)=O)(F)C1(F)F",
    "HIT":0.0,
    "question":"Is FC(C(F)(F)C(F)(F)C(F)1F)(F)C(C(NC2=CC(C(F)(F)F)=CC=C2Cl)=O)(F)C1(F)F capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":41660
  },
  {
    "COADD_ID":"CO-ADD:0225658",
    "INHIB_AVE":6.38,
    "SMILES":"C1(=N2)N(C=CN=C1Oc3cccc(OC)c3)C(N2CC(=O)Nc4c(F)ccc(F)c4)=O",
    "HIT":0.0,
    "question":"Does treatment with C1(=N2)N(C=CN=C1Oc3cccc(OC)c3)C(N2CC(=O)Nc4c(F)ccc(F)c4)=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":29593
  },
  {
    "COADD_ID":"CO-ADD:0291146",
    "INHIB_AVE":2.41,
    "SMILES":"c(c1c2ccccc2)(C3c(cc4OC)cc(c4O)OC)c([nH]n1)OC(N)=C3C#N",
    "HIT":0.0,
    "question":"Is c(c1c2ccccc2)(C3c(cc4OC)cc(c4O)OC)c([nH]n1)OC(N)=C3C#N effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":47254
  },
  {
    "COADD_ID":"CO-ADD:0255283",
    "INHIB_AVE":-4.16,
    "SMILES":"N1(c2ccc(cc2)Oc3ccccc3)C(=O)c4c(N=C1c(cc5)ccc5[N+](=O)[O-])cccc4",
    "HIT":0.0,
    "question":"Does treatment with N1(c2ccc(cc2)Oc3ccccc3)C(=O)c4c(N=C1c(cc5)ccc5[N+](=O)[O-])cccc4 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":70130
  },
  {
    "COADD_ID":"CO-ADD:0285229",
    "INHIB_AVE":0.55,
    "SMILES":"C(C#N)(=C(c1ccc(cc1)Cl)N=C(N2CC)SCC)C2=O",
    "HIT":0.0,
    "question":"Is C(C#N)(=C(c1ccc(cc1)Cl)N=C(N2CC)SCC)C2=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":55315
  },
  {
    "COADD_ID":"CO-ADD:0320081",
    "INHIB_AVE":8.54,
    "SMILES":"c1(c(ccc2C(=O)N(CC3)CCO3)C(=O)c(c4C1=O)cccc4)c2[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Can exposure to c1(c(ccc2C(=O)N(CC3)CCO3)C(=O)c(c4C1=O)cccc4)c2[N+](=O)[O-] lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":21331
  },
  {
    "COADD_ID":"CO-ADD:0221503",
    "INHIB_AVE":10.02,
    "SMILES":"S(=O)(=O)(c1ccc(cc1)Br)C(C)(C)CC(C)=O",
    "HIT":0.0,
    "question":"Is S(=O)(=O)(c1ccc(cc1)Br)C(C)(C)CC(C)=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":16951
  },
  {
    "COADD_ID":"CO-ADD:0218014",
    "INHIB_AVE":11.62,
    "SMILES":"n1c2c(oc1c3ccc(c(C)c3)C)ccc(c2)\\N=C\\c(cc4)ccc4OC(=O)c5ccc(cc5)Br",
    "HIT":0.0,
    "question":"Can n1c2c(oc1c3ccc(c(C)c3)C)ccc(c2)\\N=C\\c(cc4)ccc4OC(=O)c5ccc(cc5)Br act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":13201
  },
  {
    "COADD_ID":"CO-ADD:0164993",
    "INHIB_AVE":97.94,
    "SMILES":"CO[C@H]1\\C=C\\O[C@@]2(C)Oc3c(C2=O)c2c(O)c(C=NN4CCN(CC4)C4CCCC4)c(NC(=O)\\C(C)=C\/C=C\/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)c(O)c2c(O)c3C",
    "HIT":1.0,
    "question":"Can CO[C@H]1\\C=C\\O[C@@]2(C)Oc3c(C2=O)c2c(O)c(C=NN4CCN(CC4)C4CCCC4)c(NC(=O)\\C(C)=C\/C=C\/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)c(O)c2c(O)c3C act as an antibacterial agent targeting Escherichia coli?",
    "answer":"Yes",
    "_id":74
  },
  {
    "COADD_ID":"CO-ADD:0226381",
    "INHIB_AVE":11.84,
    "SMILES":"N1(C(C)=CC(=N2)Nc(cc3)ccc3C)C2=NN(CCOc(cc4)ccc4F)C1=O",
    "HIT":0.0,
    "question":"Does N1(C(C)=CC(=N2)Nc(cc3)ccc3C)C2=NN(CCOc(cc4)ccc4F)C1=O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":12756
  },
  {
    "COADD_ID":"CO-ADD:0312028",
    "INHIB_AVE":8.5,
    "SMILES":"N1(C(=O)CSc2ccccn2)c3c(cccc3)Sc(ccc(Cl)c4)c14",
    "HIT":0.0,
    "question":"Does N1(C(=O)CSc2ccccn2)c3c(cccc3)Sc(ccc(Cl)c4)c14 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":21464
  },
  {
    "COADD_ID":"CO-ADD:0242062",
    "INHIB_AVE":6.06,
    "SMILES":"n1(c(C)c(nn1)\\C(\\C)=N\\N=C\\c2ccccn2)c3nonc3N",
    "HIT":0.0,
    "question":"Can exposure to n1(c(C)c(nn1)\\C(\\C)=N\\N=C\\c2ccccn2)c3nonc3N lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":31026
  },
  {
    "COADD_ID":"CO-ADD:0216962",
    "INHIB_AVE":-2.68,
    "SMILES":"c1(ccc(cc1Cl)Cl)C(=O)Oc2cc(ccc2\\C=N\\NC(=O)c3ccc(cc3)NC(CC)=O)OC(=O)c4ccc(cc4Cl)Cl",
    "HIT":0.0,
    "question":"Can exposure to c1(ccc(cc1Cl)Cl)C(=O)Oc2cc(ccc2\\C=N\\NC(=O)c3ccc(cc3)NC(CC)=O)OC(=O)c4ccc(cc4Cl)Cl lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":66321
  },
  {
    "COADD_ID":"CO-ADD:0248366",
    "INHIB_AVE":-24.66,
    "SMILES":"NC1=C(C(N2C3=CC=C(CC)C=C3)=NC4=C(C=CC=C4)C2=O)SC(NC5=CC=C(CC)C=C5)=N1",
    "HIT":0.0,
    "question":"Is NC1=C(C(N2C3=CC=C(CC)C=C3)=NC4=C(C=CC=C4)C2=O)SC(NC5=CC=C(CC)C=C5)=N1 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":82450
  },
  {
    "COADD_ID":"CO-ADD:0156509",
    "INHIB_AVE":2.86,
    "SMILES":"O=C(N\/N=C\/C(C=CC=C1)=C1OCC2=CC=C(Cl)C=C2)C(C=C3)=CC=C3OCC4=CC=C(C=C4)Cl",
    "HIT":0.0,
    "question":"Can exposure to O=C(N\/N=C\/C(C=CC=C1)=C1OCC2=CC=C(Cl)C=C2)C(C=C3)=CC=C3OCC4=CC=C(C=C4)Cl lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":45302
  },
  {
    "COADD_ID":"CO-ADD:0223557",
    "INHIB_AVE":7.82,
    "SMILES":"C1(C)(C)C(C1\\C=C(\/Cl)\\Cl)C(=O)N\\N=C\\c(cc2)ccc2OCCCC",
    "HIT":0.0,
    "question":"Does C1(C)(C)C(C1\\C=C(\/Cl)\\Cl)C(=O)N\\N=C\\c(cc2)ccc2OCCCC show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":23901
  },
  {
    "COADD_ID":"CO-ADD:0245528",
    "INHIB_AVE":4.88,
    "SMILES":"C(\/CC1C)(=N\/NC(CSCC(=O)Nc2ccccc2)=O)\\c3c(C1)cc(OC)cc3",
    "HIT":0.0,
    "question":"Is C(\/CC1C)(=N\/NC(CSCC(=O)Nc2ccccc2)=O)\\c3c(C1)cc(OC)cc3 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":36184
  },
  {
    "COADD_ID":"CO-ADD:0166275",
    "INHIB_AVE":1.7,
    "SMILES":"C(=O)(c1cccs1)Nc2cccc(Cl)c2C",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C(=O)(c1cccs1)Nc2cccc(Cl)c2C?",
    "answer":"No",
    "_id":50432
  },
  {
    "COADD_ID":"CO-ADD:0295596",
    "INHIB_AVE":-3.05,
    "SMILES":"C(C(c1ccccc1)=O)(C2c3ccc(c(OC)c3)O)=C(O)C(N2CCOC)=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C(C(c1ccccc1)=O)(C2c3ccc(c(OC)c3)O)=C(O)C(N2CCOC)=O?",
    "answer":"No",
    "_id":67357
  },
  {
    "COADD_ID":"CO-ADD:0295373",
    "INHIB_AVE":4.64,
    "SMILES":"n1(c(cc2C)cc(c2Br)C)c(C)c(cc1C)C=O",
    "HIT":0.0,
    "question":"Does the proposed molecule n1(c(cc2C)cc(c2Br)C)c(C)c(cc1C)C=O exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":37287
  },
  {
    "COADD_ID":"CO-ADD:0217033",
    "INHIB_AVE":7.22,
    "SMILES":"N(\/c(cc1)ccc1Cl)=C\\c(cc2)ccc2OCC(=O)c(cc3)ccc3c4ccccc4",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound N(\/c(cc1)ccc1Cl)=C\\c(cc2)ccc2OCC(=O)c(cc3)ccc3c4ccccc4?",
    "answer":"No",
    "_id":26170
  },
  {
    "COADD_ID":"CO-ADD:0332061",
    "INHIB_AVE":0.68,
    "SMILES":"C1(C(=O)NC(c(cccc2[N+](=O)[O-])c2)CC(OCC)=O)=Cc(cc(Br)cc3OC)c3OC1=O",
    "HIT":0.0,
    "question":"Can exposure to C1(C(=O)NC(c(cccc2[N+](=O)[O-])c2)CC(OCC)=O)=Cc(cc(Br)cc3OC)c3OC1=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":54773
  },
  {
    "COADD_ID":"CO-ADD:0286969",
    "INHIB_AVE":9.58,
    "SMILES":"C(=C\/c(cc1)ccc1OC(c2ccccc2)=O)(\/C3=O)\\C(c4ccccc4)=NO3",
    "HIT":0.0,
    "question":"Is C(=C\/c(cc1)ccc1OC(c2ccccc2)=O)(\/C3=O)\\C(c4ccccc4)=NO3 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":18213
  },
  {
    "COADD_ID":"CO-ADD:0303135",
    "INHIB_AVE":-3.22,
    "SMILES":"c1(cc(OC)ccc1N(CC2)CCN2C(=O)c3ccc(cc3)C)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Is c1(cc(OC)ccc1N(CC2)CCN2C(=O)c3ccc(cc3)C)[N+](=O)[O-] effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":67805
  },
  {
    "COADD_ID":"CO-ADD:0329770",
    "INHIB_AVE":-1.09,
    "SMILES":"C1(C(F)(F)F)(NC(=O)c2ccccc2F)C(=O)N(C(=O)N1)c3ccc(cc3)F",
    "HIT":0.0,
    "question":"Is C1(C(F)(F)F)(NC(=O)c2ccccc2F)C(=O)N(C(=O)N1)c3ccc(cc3)F effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":61385
  },
  {
    "COADD_ID":"CO-ADD:0284758",
    "INHIB_AVE":5.74,
    "SMILES":"c(Nc1ccc(cc1OC)OC)(nc(Cl)nc2Nc(cc3)ccc3I)n2",
    "HIT":0.0,
    "question":"Does c(Nc1ccc(cc1OC)OC)(nc(Cl)nc2Nc(cc3)ccc3I)n2 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":32377
  },
  {
    "COADD_ID":"CO-ADD:0319554",
    "INHIB_AVE":16.22,
    "SMILES":"c1(c2ccccc2F)nnn(CC(=O)Nc(cc3)ccc3OC(F)(Cl)F)n1",
    "HIT":0.0,
    "question":"Does treatment with c1(c2ccccc2F)nnn(CC(=O)Nc(cc3)ccc3OC(F)(Cl)F)n1 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":6098
  },
  {
    "COADD_ID":"CO-ADD:0286261",
    "INHIB_AVE":3.44,
    "SMILES":"N12[C@@]([H])(CSC1c3ccc(cc3)Br)C(N(c4ccc(cc4)F)C2=S)=O",
    "HIT":0.0,
    "question":"Does the proposed molecule N12[C@@]([H])(CSC1c3ccc(cc3)Br)C(N(c4ccc(cc4)F)C2=S)=O exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":42633
  },
  {
    "COADD_ID":"CO-ADD:0155897",
    "INHIB_AVE":8.02,
    "SMILES":"N#CC1=C(N)OC(C=C2N)=C(C=C2)C1C3=CC=CC=C3C(F)(F)F",
    "HIT":0.0,
    "question":"Is N#CC1=C(N)OC(C=C2N)=C(C=C2)C1C3=CC=CC=C3C(F)(F)F capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":23121
  },
  {
    "COADD_ID":"CO-ADD:0292979",
    "INHIB_AVE":0.55,
    "SMILES":"c1(cc(Br)c(c23)cccc2)c3NC(=O)CC1c4ccccc4C(F)(F)F",
    "HIT":0.0,
    "question":"Can exposure to c1(cc(Br)c(c23)cccc2)c3NC(=O)CC1c4ccccc4C(F)(F)F lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":55306
  },
  {
    "COADD_ID":"CO-ADD:0226498",
    "INHIB_AVE":7.44,
    "SMILES":"c12n(C=CN(c3ccc(cc3)Br)C1=O)c(nn2)SCC(=O)c4ccc(cc4)OCC",
    "HIT":0.0,
    "question":"Can exposure to c12n(C=CN(c3ccc(cc3)Br)C1=O)c(nn2)SCC(=O)c4ccc(cc4)OCC lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":25304
  },
  {
    "COADD_ID":"CO-ADD:0135617",
    "INHIB_AVE":-6.94,
    "SMILES":"N1(N=O)C(C)CCC(CC)C1",
    "HIT":0.0,
    "question":"Is N1(N=O)C(C)CCC(CC)C1 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":75246
  },
  {
    "COADD_ID":"CO-ADD:0300348",
    "INHIB_AVE":-1.57,
    "SMILES":"c1(sc(c2n1)CCCC2)NC(=O)c(cc3OC)cc(c3OC)OC",
    "HIT":0.0,
    "question":"Does c1(sc(c2n1)CCCC2)NC(=O)c(cc3OC)cc(c3OC)OC show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":62968
  },
  {
    "COADD_ID":"CO-ADD:0157356",
    "INHIB_AVE":7.02,
    "SMILES":"O=C(CSC1=CC=CC=C1)N\/N=C\/C2=CC(Br)=C(O)C(OC)=C2",
    "HIT":0.0,
    "question":"Can exposure to O=C(CSC1=CC=CC=C1)N\/N=C\/C2=CC(Br)=C(O)C(OC)=C2 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":26896
  },
  {
    "COADD_ID":"CO-ADD:0221337",
    "INHIB_AVE":9.69,
    "SMILES":"c12c(c(nn1c3ccccc3)C)cc(C(=O)Nc(cc4)ccc4C(OCC)=O)s2",
    "HIT":0.0,
    "question":"Can exposure to c12c(c(nn1c3ccccc3)C)cc(C(=O)Nc(cc4)ccc4C(OCC)=O)s2 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":17890
  },
  {
    "COADD_ID":"CO-ADD:0329563",
    "INHIB_AVE":14.75,
    "SMILES":"C(=O)(NC(c1ccc(cc1)OC)CC(OCC)=O)c2ccccc2F",
    "HIT":0.0,
    "question":"Is C(=O)(NC(c1ccc(cc1)OC)CC(OCC)=O)c2ccccc2F capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":7924
  },
  {
    "COADD_ID":"CO-ADD:0233536",
    "INHIB_AVE":6.37,
    "SMILES":"[N+](=O)([O-])c(ccc(c1\\C=N\\NC(=S)Nc2ccccc2)N(CC3)CCO3)c1",
    "HIT":0.0,
    "question":"Does [N+](=O)([O-])c(ccc(c1\\C=N\\NC(=S)Nc2ccccc2)N(CC3)CCO3)c1 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":29696
  },
  {
    "COADD_ID":"CO-ADD:0157445",
    "INHIB_AVE":0.23,
    "SMILES":"O=C(C1=CC2=CC=C(C3=CC=C(Cl)C=C3)O2)NC(NC1=O)=O",
    "HIT":0.0,
    "question":"Can O=C(C1=CC2=CC=C(C3=CC=C(Cl)C=C3)O2)NC(NC1=O)=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":56526
  },
  {
    "COADD_ID":"CO-ADD:0223412",
    "INHIB_AVE":3.72,
    "SMILES":"c(cc(C(OCCCC)=O)cc1[N+](=O)[O-])([N+](=O)[O-])c1N(C)C",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c(cc(C(OCCCC)=O)cc1[N+](=O)[O-])([N+](=O)[O-])c1N(C)C?",
    "answer":"No",
    "_id":41412
  },
  {
    "COADD_ID":"CO-ADD:0233653",
    "INHIB_AVE":-4.78,
    "SMILES":"C(=O)(c1ccc(cc1)Br)Oc(cc2)ccc2\\C=N\\NC(=O)Cc3cccc(cccc4)c34",
    "HIT":0.0,
    "question":"Does the proposed molecule C(=O)(c1ccc(cc1)Br)Oc(cc2)ccc2\\C=N\\NC(=O)Cc3cccc(cccc4)c34 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":71402
  },
  {
    "COADD_ID":"CO-ADD:0255955",
    "INHIB_AVE":7.6,
    "SMILES":"n1(c2c(nn1)cccc2)C(=O)c(cc3)ccc3C(C)(C)C",
    "HIT":0.0,
    "question":"Can exposure to n1(c2c(nn1)cccc2)C(=O)c(cc3)ccc3C(C)(C)C lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":24682
  },
  {
    "COADD_ID":"CO-ADD:0219205",
    "INHIB_AVE":3.75,
    "SMILES":"C(c1ccccc1)(=O)NC(Cc2ccccc2)C(OCC)=O",
    "HIT":0.0,
    "question":"Does C(c1ccccc1)(=O)NC(Cc2ccccc2)C(OCC)=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":41285
  },
  {
    "COADD_ID":"CO-ADD:0259842",
    "INHIB_AVE":4.49,
    "SMILES":"N1(c2cccc(OC)c2)C(=O)c(c3C1=O)ccc(c3)C(=O)Nc4ccccc4O",
    "HIT":0.0,
    "question":"Does N1(c2cccc(OC)c2)C(=O)c(c3C1=O)ccc(c3)C(=O)Nc4ccccc4O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":37972
  },
  {
    "COADD_ID":"CO-ADD:0277974",
    "INHIB_AVE":0.91,
    "SMILES":"N1(c(ccc(c2s3)nc3SC)c2)C(=O)c(c4C1=O)cccc4",
    "HIT":0.0,
    "question":"Can N1(c(ccc(c2s3)nc3SC)c2)C(=O)c(c4C1=O)cccc4 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":53837
  },
  {
    "COADD_ID":"CO-ADD:0302389",
    "INHIB_AVE":4.24,
    "SMILES":"C(C#N)(C(CC(N1)=O)c2ccc(c(OC)c2)OCC)=C1SCC(=O)Nc3cccc(OC)c3",
    "HIT":0.0,
    "question":"Can C(C#N)(C(CC(N1)=O)c2ccc(c(OC)c2)OCC)=C1SCC(=O)Nc3cccc(OC)c3 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":39049
  },
  {
    "COADD_ID":"CO-ADD:0312540",
    "INHIB_AVE":5.38,
    "SMILES":"c1([C@@H]([C@@H](C(=O)N(C2)c3ccccc3)C2C4)c5ccccc5)c4sc(C)c1",
    "HIT":0.0,
    "question":"Is c1([C@@H]([C@@H](C(=O)N(C2)c3ccccc3)C2C4)c5ccccc5)c4sc(C)c1 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":33983
  },
  {
    "COADD_ID":"CO-ADD:0223342",
    "INHIB_AVE":1.35,
    "SMILES":"C(\/C#N)(=C\/c(cc1)ccc1OC)\\C(=O)Nc(ccc(c2C)C)c2",
    "HIT":0.0,
    "question":"Can C(\/C#N)(=C\/c(cc1)ccc1OC)\\C(=O)Nc(ccc(c2C)C)c2 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":51952
  },
  {
    "COADD_ID":"CO-ADD:0219723",
    "INHIB_AVE":3.1,
    "SMILES":"C(c1ccccc1)(=O)Nc(cccc2\\C(\\C)=N\/NC(CSCc(cc3)ccc3Cl)=O)c2",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C(c1ccccc1)(=O)Nc(cccc2\\C(\\C)=N\/NC(CSCc(cc3)ccc3Cl)=O)c2?",
    "answer":"No",
    "_id":44169
  },
  {
    "COADD_ID":"CO-ADD:0332112",
    "INHIB_AVE":5.24,
    "SMILES":"C1(=Cc(cccc2OC)c2OC1=O)C(=O)N(CC3)CCN3c4ccc(c(C)c4)C",
    "HIT":0.0,
    "question":"Is C1(=Cc(cccc2OC)c2OC1=O)C(=O)N(CC3)CCN3c4ccc(c(C)c4)C capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":34565
  },
  {
    "COADD_ID":"CO-ADD:0242893",
    "INHIB_AVE":-5.55,
    "SMILES":"C1(C(OCC)=O)=C(C)NC(NC1c2ccc(c(OC)c2)OC)=O",
    "HIT":0.0,
    "question":"Does C1(C(OCC)=O)=C(C)NC(NC1c2ccc(c(OC)c2)OC)=O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":72927
  },
  {
    "COADD_ID":"CO-ADD:0161910",
    "INHIB_AVE":10.92,
    "SMILES":"C1(=O)N(C)c(c2N1C)ccc(c2)\\N=C\\c(ccc3c4ccc(cc4Cl)Cl)o3",
    "HIT":0.0,
    "question":"Does C1(=O)N(C)c(c2N1C)ccc(c2)\\N=C\\c(ccc3c4ccc(cc4Cl)Cl)o3 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":14714
  },
  {
    "COADD_ID":"CO-ADD:0232623",
    "INHIB_AVE":1.34,
    "SMILES":"o1c(N)nnc1c(cccc2[N+](=O)[O-])c2",
    "HIT":0.0,
    "question":"Does o1c(N)nnc1c(cccc2[N+](=O)[O-])c2 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":51988
  },
  {
    "COADD_ID":"CO-ADD:0236489",
    "INHIB_AVE":16.95,
    "SMILES":"C(=O)(c1cccc(Cl)c1)N\\N=C(\/CC(C)(C)CC2=O)\\C2",
    "HIT":0.0,
    "question":"Can C(=O)(c1cccc(Cl)c1)N\\N=C(\/CC(C)(C)CC2=O)\\C2 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":5345
  },
  {
    "COADD_ID":"CO-ADD:0312473",
    "INHIB_AVE":-1.6,
    "SMILES":"[C@H]1(C=C2)O[C@]23[C@@H]([C@@H]1C(OC)=O)C(=O)N(CCc4cc(OC)c(OC)cc4)C3",
    "HIT":0.0,
    "question":"Can [C@H]1(C=C2)O[C@]23[C@@H]([C@@H]1C(OC)=O)C(=O)N(CCc4cc(OC)c(OC)cc4)C3 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":63088
  },
  {
    "COADD_ID":"CO-ADD:0220692",
    "INHIB_AVE":0.52,
    "SMILES":"c1(N(CC2)CCO2)nc(N\\N=C(\/C)\\c(cc3)ccc3[N+](=O)[O-])nc(Nc(cc4)ccc4C)n1",
    "HIT":0.0,
    "question":"Can exposure to c1(N(CC2)CCO2)nc(N\\N=C(\/C)\\c(cc3)ccc3[N+](=O)[O-])nc(Nc(cc4)ccc4C)n1 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":55426
  },
  {
    "COADD_ID":"CO-ADD:0324705",
    "INHIB_AVE":12.06,
    "SMILES":"C(C(c1ccccc1)=O)(C2c(cc3)ccc3C(OC)=O)=C(O)C(N2c4ccc(cc4)OCC(O)=O)=O",
    "HIT":0.0,
    "question":"Can C(C(c1ccccc1)=O)(C2c(cc3)ccc3C(OC)=O)=C(O)C(N2c4ccc(cc4)OCC(O)=O)=O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":12339
  },
  {
    "COADD_ID":"CO-ADD:0227191",
    "INHIB_AVE":-4.71,
    "SMILES":"C(CNc1cccc(cccc2)c12)(=O)N\\N=C\\c3ccccc3O",
    "HIT":0.0,
    "question":"Does C(CNc1cccc(cccc2)c12)(=O)N\\N=C\\c3ccccc3O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":71248
  },
  {
    "COADD_ID":"CO-ADD:0252717",
    "INHIB_AVE":10.32,
    "SMILES":"c1(C2=O)c(sc(COC(C)(C)C3)c13)NC(=S)N2c4ccccc4",
    "HIT":0.0,
    "question":"Does c1(C2=O)c(sc(COC(C)(C)C3)c13)NC(=S)N2c4ccccc4 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":16195
  },
  {
    "COADD_ID":"CO-ADD:0227007",
    "INHIB_AVE":14.85,
    "SMILES":"N(C=Nc1c2c3c(s1)CCCC3)(C4=O)C2=NN4CC(=O)Nc5cc(OC)cc(OC)c5",
    "HIT":0.0,
    "question":"Is N(C=Nc1c2c3c(s1)CCCC3)(C4=O)C2=NN4CC(=O)Nc5cc(OC)cc(OC)c5 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":7781
  },
  {
    "COADD_ID":"CO-ADD:0232341",
    "INHIB_AVE":10.61,
    "SMILES":"C1(=Cc2c(OC1=O)ccc(OC)c2)C(=O)Nc3ccccc3Br",
    "HIT":0.0,
    "question":"Does treatment with C1(=Cc2c(OC1=O)ccc(OC)c2)C(=O)Nc3ccccc3Br result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":15447
  },
  {
    "COADD_ID":"CO-ADD:0234784",
    "INHIB_AVE":3.89,
    "SMILES":"c1(c2ccc(OCC(=O)Oc3ccccc3)c1)OC(C=C2C)=O",
    "HIT":0.0,
    "question":"Is c1(c2ccc(OCC(=O)Oc3ccccc3)c1)OC(C=C2C)=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":40651
  },
  {
    "COADD_ID":"CO-ADD:0295111",
    "INHIB_AVE":-4.28,
    "SMILES":"C(=O)(NC(=O)Nc(ccc(c1Cl)Cl)c1)c2c(Cl)cc(nc2Cl)Cl",
    "HIT":0.0,
    "question":"Can C(=O)(NC(=O)Nc(ccc(c1Cl)Cl)c1)c2c(Cl)cc(nc2Cl)Cl effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":70372
  },
  {
    "COADD_ID":"CO-ADD:0278260",
    "INHIB_AVE":9.98,
    "SMILES":"c1(Sc2ccc(\\C=N\\NC(c(cc3)ccn3)=O)o2)nnc(c4ccccc4)n1c5ccccc5",
    "HIT":0.0,
    "question":"Can exposure to c1(Sc2ccc(\\C=N\\NC(c(cc3)ccn3)=O)o2)nnc(c4ccccc4)n1c5ccccc5 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":17041
  },
  {
    "COADD_ID":"CO-ADD:0310891",
    "INHIB_AVE":22.99,
    "SMILES":"c1(ccc(cc1N2CCCC2)N(CC3)CCN3C(=O)c4ccc(cc4)Br)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Does c1(ccc(cc1N2CCCC2)N(CC3)CCN3C(=O)c4ccc(cc4)Br)[N+](=O)[O-] show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":1617
  },
  {
    "COADD_ID":"CO-ADD:0162472",
    "INHIB_AVE":0.2,
    "SMILES":"C(Cl)(Cl)(Cl)C(O)NC(CSC(N(CC)CC)=S)=O",
    "HIT":0.0,
    "question":"Can C(Cl)(Cl)(Cl)C(O)NC(CSC(N(CC)CC)=S)=O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":56665
  },
  {
    "COADD_ID":"CO-ADD:0323366",
    "INHIB_AVE":2.03,
    "SMILES":"S(NCCc(ccc(c1OCC)OCC)c1)(=O)(=O)c(c(C)ccc2c3c4c(cccc4)c(nn3)Nc(cc5)ccc5Cl)c2",
    "HIT":0.0,
    "question":"Does S(NCCc(ccc(c1OCC)OCC)c1)(=O)(=O)c(c(C)ccc2c3c4c(cccc4)c(nn3)Nc(cc5)ccc5Cl)c2 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":48975
  },
  {
    "COADD_ID":"CO-ADD:0162679",
    "INHIB_AVE":6.96,
    "SMILES":"c(C#N)(cc(C(C)=O)c(n1)C)c1SC\\C=C\\c2ccccc2",
    "HIT":0.0,
    "question":"Does treatment with c(C#N)(cc(C(C)=O)c(n1)C)c1SC\\C=C\\c2ccccc2 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":27169
  },
  {
    "COADD_ID":"CO-ADD:0250682",
    "INHIB_AVE":-34.39,
    "SMILES":"C(=O)(Oc(cc1)ccc1C(=S)N(CC2)CCO2)c3ccccc3Cl",
    "HIT":0.0,
    "question":"Can C(=O)(Oc(cc1)ccc1C(=S)N(CC2)CCO2)c3ccccc3Cl act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":82639
  },
  {
    "COADD_ID":"CO-ADD:0233489",
    "INHIB_AVE":-7.27,
    "SMILES":"c1(c(ccc(c2Cl)Cl)c2)ccc(\\C=N\\NC(=O)c(c3)cc(cn3)Br)o1",
    "HIT":0.0,
    "question":"Does c1(c(ccc(c2Cl)Cl)c2)ccc(\\C=N\\NC(=O)c(c3)cc(cn3)Br)o1 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":75724
  },
  {
    "COADD_ID":"CO-ADD:0154881",
    "INHIB_AVE":2.35,
    "SMILES":"N#CC(C(C1=CSC=C1)C(C2=O)=C(C(C=CC=C3)=C3O2)O4)=C4N",
    "HIT":0.0,
    "question":"Is N#CC(C(C1=CSC=C1)C(C2=O)=C(C(C=CC=C3)=C3O2)O4)=C4N capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":47534
  },
  {
    "COADD_ID":"CO-ADD:0164743",
    "INHIB_AVE":2.56,
    "SMILES":"CC(C)c1ccc2oc3nc(N)c(cc3c(=O)c2c1)C(O)=O",
    "HIT":0.0,
    "question":"Is CC(C)c1ccc2oc3nc(N)c(cc3c(=O)c2c1)C(O)=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":46613
  },
  {
    "COADD_ID":"CO-ADD:0288663",
    "INHIB_AVE":1.9,
    "SMILES":"C(=O)(OC(C)(C)C)N(CCC1c(n(c2C)CC3CC3)nc2)CC1",
    "HIT":0.0,
    "question":"Does C(=O)(OC(C)(C)C)N(CCC1c(n(c2C)CC3CC3)nc2)CC1 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":49557
  },
  {
    "COADD_ID":"CO-ADD:0229965",
    "INHIB_AVE":13.77,
    "SMILES":"C(=C\\c(ccc(c1OC)O)c1)(\/C(=O)NC(N2)=S)\\C2=O",
    "HIT":0.0,
    "question":"Does C(=C\\c(ccc(c1OC)O)c1)(\/C(=O)NC(N2)=S)\\C2=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":9375
  },
  {
    "COADD_ID":"CO-ADD:0324831",
    "INHIB_AVE":-6.84,
    "SMILES":"c1(SC(C)CN(C)C)nc(C)cc(N)n1",
    "HIT":0.0,
    "question":"Does the proposed molecule c1(SC(C)CN(C)C)nc(C)cc(N)n1 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":75100
  },
  {
    "COADD_ID":"CO-ADD:0232065",
    "INHIB_AVE":14.96,
    "SMILES":"C(=O)(c1ccccc1Br)Oc2c(Br)cc(cc2\\C=N\\NC(COc3ccccc3C)=O)Br",
    "HIT":0.0,
    "question":"Does C(=O)(c1ccccc1Br)Oc2c(Br)cc(cc2\\C=N\\NC(COc3ccccc3C)=O)Br show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":7645
  },
  {
    "COADD_ID":"CO-ADD:0285232",
    "INHIB_AVE":-6.16,
    "SMILES":"c1(c(NCCOc2cccc(cccc3)c23)ccc(c1)[N+](=O)[O-])C(F)(F)F",
    "HIT":0.0,
    "question":"Is c1(c(NCCOc2cccc(cccc3)c23)ccc(c1)[N+](=O)[O-])C(F)(F)F effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":74028
  },
  {
    "COADD_ID":"CO-ADD:0319393",
    "INHIB_AVE":3.3,
    "SMILES":"C1(=O)c2c(CN1CCNC(=O)c3ccc(cc3)Oc(cc4)ccc4C(NCCN5Cc(c6C5=O)cccc6)=O)cccc2",
    "HIT":0.0,
    "question":"Can exposure to C1(=O)c2c(CN1CCNC(=O)c3ccc(cc3)Oc(cc4)ccc4C(NCCN5Cc(c6C5=O)cccc6)=O)cccc2 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":43257
  },
  {
    "COADD_ID":"CO-ADD:0222709",
    "INHIB_AVE":6.39,
    "SMILES":"C12(\\C=N\\c3ccccc3C(O)=O)c4c(cccc4)C(C(C1C5=O)C(N5c6ccc(cc6)OCC)=O)c(cccc7)c27",
    "HIT":0.0,
    "question":"Is C12(\\C=N\\c3ccccc3C(O)=O)c4c(cccc4)C(C(C1C5=O)C(N5c6ccc(cc6)OCC)=O)c(cccc7)c27 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":29579
  },
  {
    "COADD_ID":"CO-ADD:0231872",
    "INHIB_AVE":1.38,
    "SMILES":"n1c(ccc(c2)\\N=C\\c(ccc(c3[N+](=O)[O-])Br)c3)c2oc1c4ccc(cc4)Br",
    "HIT":0.0,
    "question":"Does n1c(ccc(c2)\\N=C\\c(ccc(c3[N+](=O)[O-])Br)c3)c2oc1c4ccc(cc4)Br demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":51837
  },
  {
    "COADD_ID":"CO-ADD:0319571",
    "INHIB_AVE":7.16,
    "SMILES":"c1(N(CC2)CCO2)nc(Cn3nnc(c(ccc(c45)OCO4)c5)n3)nc(N)n1",
    "HIT":0.0,
    "question":"Is c1(N(CC2)CCO2)nc(Cn3nnc(c(ccc(c45)OCO4)c5)n3)nc(N)n1 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":26375
  },
  {
    "COADD_ID":"CO-ADD:0324905",
    "INHIB_AVE":18.32,
    "SMILES":"n12c(nc(cc1C(F)(F)Cl)c3ccco3)cc(C(=O)Nc4cc(C)ccc4OC)n2",
    "HIT":0.0,
    "question":"Can n12c(nc(cc1C(F)(F)Cl)c3ccco3)cc(C(=O)Nc4cc(C)ccc4OC)n2 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":4044
  },
  {
    "COADD_ID":"CO-ADD:0326868",
    "INHIB_AVE":-1.16,
    "SMILES":"n1(c2c(nn1)cccc2)c3cc(C#N)c(cc3Oc(cc4)ccc4F)C#N",
    "HIT":0.0,
    "question":"Does n1(c2c(nn1)cccc2)c3cc(C#N)c(cc3Oc(cc4)ccc4F)C#N demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":61630
  },
  {
    "COADD_ID":"CO-ADD:0253845",
    "INHIB_AVE":2.68,
    "SMILES":"c1(c2c(s3)CCCC2)c3N=CN(\\N=C\\c(cc4OCC)cc(c4OC)Br)C1=O",
    "HIT":0.0,
    "question":"Does c1(c2c(s3)CCCC2)c3N=CN(\\N=C\\c(cc4OCC)cc(c4OC)Br)C1=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":46049
  },
  {
    "COADD_ID":"CO-ADD:0227389",
    "INHIB_AVE":0.56,
    "SMILES":"[N+](=O)([O-])c(cc1)ccc1C(=O)Oc2cccc(c2)\\C=N\\NC(CNC(=O)c3ccccc3Br)=O",
    "HIT":0.0,
    "question":"Does [N+](=O)([O-])c(cc1)ccc1C(=O)Oc2cccc(c2)\\C=N\\NC(CNC(=O)c3ccccc3Br)=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":55261
  },
  {
    "COADD_ID":"CO-ADD:0228792",
    "INHIB_AVE":-0.03,
    "SMILES":"N1(c2ccc(c(C)c2)C)C(=O)\\C(\\C(C)=N1)=C\/Nc(ccc(c3[N+](=O)[O-])Cl)c3",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound N1(c2ccc(c(C)c2)C)C(=O)\\C(\\C(C)=N1)=C\/Nc(ccc(c3[N+](=O)[O-])Cl)c3?",
    "answer":"No",
    "_id":57585
  },
  {
    "COADD_ID":"CO-ADD:0326443",
    "INHIB_AVE":6.63,
    "SMILES":"N1\\C(=N\/N=C(\\C)\/c(cc2)ccc2[N+](=O)[O-])\\SC(C)C1=O",
    "HIT":0.0,
    "question":"Is N1\\C(=N\/N=C(\\C)\/c(cc2)ccc2[N+](=O)[O-])\\SC(C)C1=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":28573
  },
  {
    "COADD_ID":"CO-ADD:0228070",
    "INHIB_AVE":7.54,
    "SMILES":"N(\\C(=C\/c(cc1)ccc1OCc2ccccc2)\\C(O3)=O)=C3c4ccc(cc4)C",
    "HIT":0.0,
    "question":"Can exposure to N(\\C(=C\/c(cc1)ccc1OCc2ccccc2)\\C(O3)=O)=C3c4ccc(cc4)C lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":24917
  },
  {
    "COADD_ID":"CO-ADD:0248908",
    "INHIB_AVE":-2.63,
    "SMILES":"C1(C(OCCOc2ccccc2)=O)=C(C)NC(NC1c(ccc(c34)OCO3)c4)=O",
    "HIT":0.0,
    "question":"Can exposure to C1(C(OCCOc2ccccc2)=O)=C(C)NC(NC1c(ccc(c34)OCO3)c4)=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":66192
  },
  {
    "COADD_ID":"CO-ADD:0302044",
    "INHIB_AVE":38.58,
    "SMILES":"N1(c2ccc(cc2)OC)C(=O)NC(\\C(=C\\c3cccc(OCCOc(cc4)ccc4[N+](=O)[O-])c3)\\C1=O)=O",
    "HIT":0.0,
    "question":"Does treatment with N1(c2ccc(cc2)OC)C(=O)NC(\\C(=C\\c3cccc(OCCOc(cc4)ccc4[N+](=O)[O-])c3)\\C1=O)=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":569
  },
  {
    "COADD_ID":"CO-ADD:0326648",
    "INHIB_AVE":26.56,
    "SMILES":"n12c(nc(cc1C(F)(F)Cl)c3cccs3)cc(C(=O)Nc4ccccc4C(OC)=O)n2",
    "HIT":0.0,
    "question":"Does treatment with n12c(nc(cc1C(F)(F)Cl)c3cccs3)cc(C(=O)Nc4ccccc4C(OC)=O)n2 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":982
  },
  {
    "COADD_ID":"CO-ADD:0157459",
    "INHIB_AVE":6.19,
    "SMILES":"OC1=C(C2=CC=C(CC)C=C2)C3=NC4=CC=CC=C4N=C3C5=CC=CC=C15",
    "HIT":0.0,
    "question":"Can exposure to OC1=C(C2=CC=C(CC)C=C2)C3=NC4=CC=CC=C4N=C3C5=CC=CC=C15 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":30461
  },
  {
    "COADD_ID":"CO-ADD:0159885",
    "INHIB_AVE":0.26,
    "SMILES":"CC1=CC=C(C)N1C(C=C2)=CC=C2C3=CC=C(C=C3)N4C(C)=CC=C4C",
    "HIT":0.0,
    "question":"Can CC1=CC=C(C)N1C(C=C2)=CC=C2C3=CC=C(C=C3)N4C(C)=CC=C4C act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":56421
  },
  {
    "COADD_ID":"CO-ADD:0311126",
    "INHIB_AVE":2.18,
    "SMILES":"c1(cc(Br)ccc1OCC(=O)NC2CCCCC2)C(=O)Nc(cc3)ccc3Cl",
    "HIT":0.0,
    "question":"Does c1(cc(Br)ccc1OCC(=O)NC2CCCCC2)C(=O)Nc(cc3)ccc3Cl show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":48309
  },
  {
    "COADD_ID":"CO-ADD:0301640",
    "INHIB_AVE":5.34,
    "SMILES":"C12=C(CC(c3ccc(cc3)OC)CC1=O)Nc(c4NC2c5ccc(cc5)OC)cccc4",
    "HIT":0.0,
    "question":"Can exposure to C12=C(CC(c3ccc(cc3)OC)CC1=O)Nc(c4NC2c5ccc(cc5)OC)cccc4 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":34135
  },
  {
    "COADD_ID":"CO-ADD:0258022",
    "INHIB_AVE":10.01,
    "SMILES":"c1(cc(Br)ccc1OC(=O)c(cc2)ccc2[N+](=O)[O-])C(=S)N3CCCCC3",
    "HIT":0.0,
    "question":"Can exposure to c1(cc(Br)ccc1OC(=O)c(cc2)ccc2[N+](=O)[O-])C(=S)N3CCCCC3 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":16963
  },
  {
    "COADD_ID":"CO-ADD:0136845",
    "INHIB_AVE":-0.45,
    "SMILES":"c1ccc(C2C([N+](=O)[O-])C23c4c(c(cccc5)c35)cccc4)cc1",
    "HIT":0.0,
    "question":"Does the proposed molecule c1ccc(C2C([N+](=O)[O-])C23c4c(c(cccc5)c35)cccc4)cc1 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":59217
  },
  {
    "COADD_ID":"CO-ADD:0243536",
    "INHIB_AVE":10.89,
    "SMILES":"c(c1C2C(C(=O)OCC)C(=O)NC2)c(OC)c(OCO3)c3c1OC",
    "HIT":0.0,
    "question":"Does treatment with c(c1C2C(C(=O)OCC)C(=O)NC2)c(OC)c(OCO3)c3c1OC result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":14771
  },
  {
    "COADD_ID":"CO-ADD:0156060",
    "INHIB_AVE":4.11,
    "SMILES":"BrC1=CC=C(C=C1)\/C=N\/C2=CC=C(C=C2)C(O3)=NC4=C3C=CC(C)=C4",
    "HIT":0.0,
    "question":"Does BrC1=CC=C(C=C1)\/C=N\/C2=CC=C(C=C2)C(O3)=NC4=C3C=CC(C)=C4 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":39658
  },
  {
    "COADD_ID":"CO-ADD:0296121",
    "INHIB_AVE":-8.81,
    "SMILES":"c1(ccc(cc1N(CC2)CCO2)N(CC3)CCN3CC(=O)N(CC4)CCO4)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Can c1(ccc(cc1N(CC2)CCO2)N(CC3)CCN3CC(=O)N(CC4)CCO4)[N+](=O)[O-] effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":77638
  },
  {
    "COADD_ID":"CO-ADD:0328673",
    "INHIB_AVE":19.27,
    "SMILES":"S(=O)(=O)(c(cccc1C(=O)Nc(cccc2[N+](=O)[O-])c2)c1)NC(CC)C34CC5CC(CC(C5)C3)C4",
    "HIT":0.0,
    "question":"Can S(=O)(=O)(c(cccc1C(=O)Nc(cccc2[N+](=O)[O-])c2)c1)NC(CC)C34CC5CC(CC(C5)C3)C4 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":3333
  },
  {
    "COADD_ID":"CO-ADD:0155851",
    "INHIB_AVE":-2.36,
    "SMILES":"[O-][N+](C1=CC=CC(NC(OC2=CC=C(C=C2)C(NC3=CC=C4C=CC=CC4=C3)=O)=S)=C1)=O",
    "HIT":0.0,
    "question":"Is [O-][N+](C1=CC=CC(NC(OC2=CC=C(C=C2)C(NC3=CC=C4C=CC=CC4=C3)=O)=S)=C1)=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":65427
  },
  {
    "COADD_ID":"CO-ADD:0236090",
    "INHIB_AVE":15.18,
    "SMILES":"C(=O)(c1cccc(C)c1)Nc(cc2)ccc2C#N",
    "HIT":0.0,
    "question":"Can exposure to C(=O)(c1cccc(C)c1)Nc(cc2)ccc2C#N lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":7373
  },
  {
    "COADD_ID":"CO-ADD:0302130",
    "INHIB_AVE":12.84,
    "SMILES":"N1(C2CCCCC2)C(=O)c(c3C1=O)ccc(c3)C4=Nc(c5C(=O)O4)cccc5",
    "HIT":0.0,
    "question":"Does treatment with N1(C2CCCCC2)C(=O)c(c3C1=O)ccc(c3)C4=Nc(c5C(=O)O4)cccc5 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":10872
  },
  {
    "COADD_ID":"CO-ADD:0277501",
    "INHIB_AVE":-4.46,
    "SMILES":"C1(C(=O)OC(C)C)=C(C)NC(NC1c(cc2)cc(c2OC(F)F)OC)=O",
    "HIT":0.0,
    "question":"Is C1(C(=O)OC(C)C)=C(C)NC(NC1c(cc2)cc(c2OC(F)F)OC)=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":70757
  },
  {
    "COADD_ID":"CO-ADD:0252676",
    "INHIB_AVE":4.75,
    "SMILES":"S(=O)(=O)(c(cc1)ccc1c(cc2)ccc2S(=O)(=O)c3ccc(cc3)C)Oc(ccc(c4C)C)c4",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound S(=O)(=O)(c(cc1)ccc1c(cc2)ccc2S(=O)(=O)c3ccc(cc3)C)Oc(ccc(c4C)C)c4?",
    "answer":"No",
    "_id":36783
  },
  {
    "COADD_ID":"CO-ADD:0326205",
    "INHIB_AVE":6.63,
    "SMILES":"C(C(=O)c1ccc(cc1)Cl)(C2c3ccc(cc3)Br)=C(O)C(N2CC(OCC)=O)=O",
    "HIT":0.0,
    "question":"Can exposure to C(C(=O)c1ccc(cc1)Cl)(C2c3ccc(cc3)Br)=C(O)C(N2CC(OCC)=O)=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":28596
  },
  {
    "COADD_ID":"CO-ADD:0294538",
    "INHIB_AVE":9.44,
    "SMILES":"c(cc(C(O)=O)cc1[N+](=O)[O-])([N+](=O)[O-])c1N(CC2)CCO2",
    "HIT":0.0,
    "question":"Can c(cc(C(O)=O)cc1[N+](=O)[O-])([N+](=O)[O-])c1N(CC2)CCO2 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":18639
  },
  {
    "COADD_ID":"CO-ADD:0227543",
    "INHIB_AVE":15.21,
    "SMILES":"[N+](=O)([O-])c1ccc(cc1O)\\C=N\\NC(=O)\\C(=C\\c(ccc(c23)OCO2)c3)\\NC(c4ccccc4)=O",
    "HIT":0.0,
    "question":"Can [N+](=O)([O-])c1ccc(cc1O)\\C=N\\NC(=O)\\C(=C\\c(ccc(c23)OCO2)c3)\\NC(c4ccccc4)=O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":7317
  },
  {
    "COADD_ID":"CO-ADD:0300601",
    "INHIB_AVE":4.42,
    "SMILES":"C1(=COc(c2C1=O)ccc(C)c2)C3C4=C(CC(C)(C)CC4=O)NC(C)=C3C(=O)OCC5CCCO5",
    "HIT":0.0,
    "question":"Does treatment with C1(=COc(c2C1=O)ccc(C)c2)C3C4=C(CC(C)(C)CC4=O)NC(C)=C3C(=O)OCC5CCCO5 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":38284
  },
  {
    "COADD_ID":"CO-ADD:0323313",
    "INHIB_AVE":12.08,
    "SMILES":"n1(CC=C)c(c2ccc(c(Cl)c2)Cl)nnc1Sc3c(c4ccccc4)c5c(nc3O)cccc5",
    "HIT":0.0,
    "question":"Can n1(CC=C)c(c2ccc(c(Cl)c2)Cl)nnc1Sc3c(c4ccccc4)c5c(nc3O)cccc5 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":12299
  },
  {
    "COADD_ID":"CO-ADD:0162591",
    "INHIB_AVE":11.05,
    "SMILES":"[N+](=O)([O-])c1cc(ccc1OC)\\C=N\\NC(Cc2ccccc2)=O",
    "HIT":0.0,
    "question":"Is [N+](=O)([O-])c1cc(ccc1OC)\\C=N\\NC(Cc2ccccc2)=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":14413
  },
  {
    "COADD_ID":"CO-ADD:0242029",
    "INHIB_AVE":-7.82,
    "SMILES":"C(C#N)(C(c(cc1OC)cc(c1OC)OC)C2=C(N3c4cccc(c4)[N+](=O)[O-])CCCC2=O)=C3N",
    "HIT":0.0,
    "question":"Can C(C#N)(C(c(cc1OC)cc(c1OC)OC)C2=C(N3c4cccc(c4)[N+](=O)[O-])CCCC2=O)=C3N effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":76496
  },
  {
    "COADD_ID":"CO-ADD:0312510",
    "INHIB_AVE":6.75,
    "SMILES":"C(C1[C@@H]2C(=O)N(c3ccccc3)C1)c(c4[C@]2(C(=O)O)C)scc4",
    "HIT":0.0,
    "question":"Does C(C1[C@@H]2C(=O)N(c3ccccc3)C1)c(c4[C@]2(C(=O)O)C)scc4 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":28049
  },
  {
    "COADD_ID":"CO-ADD:0228443",
    "INHIB_AVE":15.04,
    "SMILES":"N1(c2ccc(cc2)C)CC(CC1=O)C(=O)OCC(=O)c3ccc(cc3)Cl",
    "HIT":0.0,
    "question":"Can exposure to N1(c2ccc(cc2)C)CC(CC1=O)C(=O)OCC(=O)c3ccc(cc3)Cl lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":7549
  },
  {
    "COADD_ID":"CO-ADD:0223167",
    "INHIB_AVE":3.54,
    "SMILES":"c1(c(C)cccc1C)OCC(=O)N\\N=C\\c(ccc(c2I)O)c2",
    "HIT":0.0,
    "question":"Can c1(c(C)cccc1C)OCC(=O)N\\N=C\\c(ccc(c2I)O)c2 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":42191
  },
  {
    "COADD_ID":"CO-ADD:0252446",
    "INHIB_AVE":7.74,
    "SMILES":"S(=O)(=O)(c1ccc(c(OC)c1)OC)N(CC(=O)N\\N=C(\/C)\\C(C)(C)C)c2cc(C)cc(C)c2",
    "HIT":0.0,
    "question":"Does the proposed molecule S(=O)(=O)(c1ccc(c(OC)c1)OC)N(CC(=O)N\\N=C(\/C)\\C(C)(C)C)c2cc(C)cc(C)c2 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":24171
  },
  {
    "COADD_ID":"CO-ADD:0291756",
    "INHIB_AVE":13.01,
    "SMILES":"N1(C2c3ccc(c(OC)c3)OC)C(S\\C(=C\\c(ccc4c(ccc(c5[N+](=O)[O-])Cl)c5)o4)\\C1=O)=NC(C)=C2C(OCC)=O",
    "HIT":0.0,
    "question":"Can exposure to N1(C2c3ccc(c(OC)c3)OC)C(S\\C(=C\\c(ccc4c(ccc(c5[N+](=O)[O-])Cl)c5)o4)\\C1=O)=NC(C)=C2C(OCC)=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":10545
  },
  {
    "COADD_ID":"CO-ADD:0301723",
    "INHIB_AVE":8.42,
    "SMILES":"C(=C\\c(ccc(c1OCC)OCCOc(cc2)ccc2C(C)(C)C)c1)(\/C(=O)NC(N3)=O)\\C3=O",
    "HIT":0.0,
    "question":"Does treatment with C(=C\\c(ccc(c1OCC)OCCOc(cc2)ccc2C(C)(C)C)c1)(\/C(=O)NC(N3)=O)\\C3=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":21748
  },
  {
    "COADD_ID":"CO-ADD:0137047",
    "INHIB_AVE":1.75,
    "SMILES":"O1CC=C(C2)C(CC(C(CC3)(C4N5[H])C(=CC6=O)C5=C([N+](=O)[O-])C6=O)N23)C4C1CC(=O)OC",
    "HIT":0.0,
    "question":"Does O1CC=C(C2)C(CC(C(CC3)(C4N5[H])C(=CC6=O)C5=C([N+](=O)[O-])C6=O)N23)C4C1CC(=O)OC show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":50225
  },
  {
    "COADD_ID":"CO-ADD:0283930",
    "INHIB_AVE":-4.25,
    "SMILES":"[N+](=O)([O-])c1c(ccc(c1)C(F)(F)F)SCC(NCCOc2cccc(cccc3)c23)=O",
    "HIT":0.0,
    "question":"Is [N+](=O)([O-])c1c(ccc(c1)C(F)(F)F)SCC(NCCOc2cccc(cccc3)c23)=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":70321
  },
  {
    "COADD_ID":"CO-ADD:0163724",
    "INHIB_AVE":-5.4,
    "SMILES":"C(Oc(cccc1C(=O)Nc(ccc(c23)cccc2)c3)c1)(=S)Nc4cccc(C)c4C",
    "HIT":0.0,
    "question":"Can C(Oc(cccc1C(=O)Nc(ccc(c23)cccc2)c3)c1)(=S)Nc4cccc(C)c4C act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":72654
  },
  {
    "COADD_ID":"CO-ADD:0162332",
    "INHIB_AVE":11.06,
    "SMILES":"c1(OCC(=O)N\\N=C\\c(cc2)ccc2C(OC)=O)c(Cl)cc(cc1Cl)Cl",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(OCC(=O)N\\N=C\\c(cc2)ccc2C(OC)=O)c(Cl)cc(cc1Cl)Cl?",
    "answer":"No",
    "_id":14385
  },
  {
    "COADD_ID":"CO-ADD:0237182",
    "INHIB_AVE":22.03,
    "SMILES":"Brc1ccc2NC(=O)C3(NCCc4c3[nH]c5ccccc45)c2c1",
    "HIT":0.0,
    "question":"Is Brc1ccc2NC(=O)C3(NCCc4c3[nH]c5ccccc45)c2c1 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":1938
  },
  {
    "COADD_ID":"CO-ADD:0232089",
    "INHIB_AVE":7.84,
    "SMILES":"C(=O)(Oc1ccc(cc1OC)\\C=N\\NC(COc2ccccc2C)=O)c3ccccc3Cl",
    "HIT":0.0,
    "question":"Does C(=O)(Oc1ccc(cc1OC)\\C=N\\NC(COc2ccccc2C)=O)c3ccccc3Cl demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":23805
  },
  {
    "COADD_ID":"CO-ADD:0278524",
    "INHIB_AVE":-4.09,
    "SMILES":"C1(=O)OC2(C(=C)N1c3ccc(cc3)Cl)CCCCC2",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C1(=O)OC2(C(=C)N1c3ccc(cc3)Cl)CCCCC2?",
    "answer":"No",
    "_id":69949
  },
  {
    "COADD_ID":"CO-ADD:0299825",
    "INHIB_AVE":9.54,
    "SMILES":"C(=C\/c(ccc(c12)OCO1)c2)(\/C(=O)NC(N3C)=O)\\C3=O",
    "HIT":0.0,
    "question":"Does C(=C\/c(ccc(c12)OCO1)c2)(\/C(=O)NC(N3C)=O)\\C3=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":18283
  },
  {
    "COADD_ID":"CO-ADD:0303635",
    "INHIB_AVE":-6.78,
    "SMILES":"n1c(c2ccc(cc2)C)onc1c3ccccc3",
    "HIT":0.0,
    "question":"Does treatment with n1c(c2ccc(cc2)C)onc1c3ccccc3 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":74994
  },
  {
    "COADD_ID":"CO-ADD:0227078",
    "INHIB_AVE":1.64,
    "SMILES":"N1(c(cc2)ccc2C(=O)OCC(=O)Nc(cc3)ccc3C(OC)=O)C(=O)CCC1=O",
    "HIT":0.0,
    "question":"Is N1(c(cc2)ccc2C(=O)OCC(=O)Nc(cc3)ccc3C(OC)=O)C(=O)CCC1=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":50715
  },
  {
    "COADD_ID":"CO-ADD:0230357",
    "INHIB_AVE":5.88,
    "SMILES":"C(CSCC(=O)Nc(cc1)ccc1OCCCCC)(=O)Nc(ccc(c23)cccc2)c3",
    "HIT":0.0,
    "question":"Is C(CSCC(=O)Nc(cc1)ccc1OCCCCC)(=O)Nc(ccc(c23)cccc2)c3 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":31738
  },
  {
    "COADD_ID":"CO-ADD:0228380",
    "INHIB_AVE":-5.65,
    "SMILES":"c1(csc(Nc2ccccc2)n1)c3cc(c4o3)cccc4",
    "HIT":0.0,
    "question":"Is c1(csc(Nc2ccccc2)n1)c3cc(c4o3)cccc4 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":73085
  },
  {
    "COADD_ID":"CO-ADD:0227669",
    "INHIB_AVE":-2.09,
    "SMILES":"c1(COc2ccc(cc2Cl)Cl)n(CCC#N)c3c(cccc3)n1",
    "HIT":0.0,
    "question":"Is c1(COc2ccc(cc2Cl)Cl)n(CCC#N)c3c(cccc3)n1 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":64626
  },
  {
    "COADD_ID":"CO-ADD:0135882",
    "INHIB_AVE":11.23,
    "SMILES":"O1c(ccc(O)c2)c2C(C=C1c(cccc3)c3)=O",
    "HIT":0.0,
    "question":"Is O1c(ccc(O)c2)c2C(C=C1c(cccc3)c3)=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":14016
  },
  {
    "COADD_ID":"CO-ADD:0160305",
    "INHIB_AVE":-0.76,
    "SMILES":"O=C1NC(C(Br)=CC(C)=C2)=C2\/C1=N\/NC(COC3=CC(Br)=CC=C3)=O",
    "HIT":0.0,
    "question":"Is O=C1NC(C(Br)=CC(C)=C2)=C2\/C1=N\/NC(COC3=CC(Br)=CC=C3)=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":60284
  },
  {
    "COADD_ID":"CO-ADD:0232019",
    "INHIB_AVE":-0.78,
    "SMILES":"C(=O)(Oc1ccc(cc1OC)\\C=N\\NC(COc(cc2)ccc2C(C)(C)CC(C)(C)C)=O)c3ccccc3Br",
    "HIT":0.0,
    "question":"Does the proposed molecule C(=O)(Oc1ccc(cc1OC)\\C=N\\NC(COc(cc2)ccc2C(C)(C)CC(C)(C)C)=O)c3ccccc3Br exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":60339
  },
  {
    "COADD_ID":"CO-ADD:0311274",
    "INHIB_AVE":-3.1,
    "SMILES":"N1(c2ccccc2)C(=O)C(CCC)C(NC1=S)=O",
    "HIT":0.0,
    "question":"Can exposure to N1(c2ccccc2)C(=O)C(CCC)C(NC1=S)=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":67503
  },
  {
    "COADD_ID":"CO-ADD:0327205",
    "INHIB_AVE":-1.14,
    "SMILES":"n1(c2c(C)cccc2C)nnnc1C(NCCc(c3c([nH]4)cccc3)c4C)c5ccc(cc5)Cl",
    "HIT":0.0,
    "question":"Is n1(c2c(C)cccc2C)nnnc1C(NCCc(c3c([nH]4)cccc3)c4C)c5ccc(cc5)Cl effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":61566
  },
  {
    "COADD_ID":"CO-ADD:0162500",
    "INHIB_AVE":2.34,
    "SMILES":"c(C(=O)Nc1nc(c2n1CCN(CC3)CCO3)cccc2)(c(c4ccccc4)nn5c6ccccc6)c5C",
    "HIT":0.0,
    "question":"Is c(C(=O)Nc1nc(c2n1CCN(CC3)CCO3)cccc2)(c(c4ccccc4)nn5c6ccccc6)c5C effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":47604
  },
  {
    "COADD_ID":"CO-ADD:0256999",
    "INHIB_AVE":-4.03,
    "SMILES":"c1(c2)c(cc(OC)c2NC(=O)c3ccc(cc3)OCCCCCCCCCC)c4c(cccc4)o1",
    "HIT":0.0,
    "question":"Is c1(c2)c(cc(OC)c2NC(=O)c3ccc(cc3)OCCCCCCCCCC)c4c(cccc4)o1 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":69835
  },
  {
    "COADD_ID":"CO-ADD:0257729",
    "INHIB_AVE":0.84,
    "SMILES":"c1(N\\N=C\\c(ccc2c(cc3)ccc3C(OC)=O)o2)[nH]c(c4n1)cccc4",
    "HIT":0.0,
    "question":"Is c1(N\\N=C\\c(ccc2c(cc3)ccc3C(OC)=O)o2)[nH]c(c4n1)cccc4 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":54129
  },
  {
    "COADD_ID":"CO-ADD:0240915",
    "INHIB_AVE":6.05,
    "SMILES":"N1(CCCc(cccc2)c12)C(=O)\\C=C\\c3ccco3",
    "HIT":0.0,
    "question":"Does treatment with N1(CCCc(cccc2)c12)C(=O)\\C=C\\c3ccco3 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":31051
  },
  {
    "COADD_ID":"CO-ADD:0253937",
    "INHIB_AVE":10.31,
    "SMILES":"C1(C(=O)Oc(c23)ccc(c2)[N+](=O)[O-])=C3S\\C(=C(\/C#N)\\C#N)\\S1",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C1(C(=O)Oc(c23)ccc(c2)[N+](=O)[O-])=C3S\\C(=C(\/C#N)\\C#N)\\S1?",
    "answer":"No",
    "_id":16225
  },
  {
    "COADD_ID":"CO-ADD:0161206",
    "INHIB_AVE":-13.06,
    "SMILES":"N1(c2ccc(cc2)Cl)C(=O)\\C(\\C(C)=N1)=C\/Nc(cc3)ccc3S(=O)(=O)Nc(cc4)ccc4OCC",
    "HIT":0.0,
    "question":"Can N1(c2ccc(cc2)Cl)C(=O)\\C(\\C(C)=N1)=C\/Nc(cc3)ccc3S(=O)(=O)Nc(cc4)ccc4OCC act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":80544
  },
  {
    "COADD_ID":"CO-ADD:0257060",
    "INHIB_AVE":-9.33,
    "SMILES":"C(=O)(Nc(ccc(c1Cl)F)c1)C2CC=CCC2C(O)=O",
    "HIT":0.0,
    "question":"Does C(=O)(Nc(ccc(c1Cl)F)c1)C2CC=CCC2C(O)=O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":78184
  },
  {
    "COADD_ID":"CO-ADD:0284058",
    "INHIB_AVE":16.67,
    "SMILES":"n(c(c1)c2ccc1C(O)=O)c(c3ccc(cc3)F)c(n2)c(cc4)ccc4c5ccccc5",
    "HIT":0.0,
    "question":"Does n(c(c1)c2ccc1C(O)=O)c(c3ccc(cc3)F)c(n2)c(cc4)ccc4c5ccccc5 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":5616
  },
  {
    "COADD_ID":"CO-ADD:0242777",
    "INHIB_AVE":17.61,
    "SMILES":"N(CCNc1cccc(CC)c1)c2cccc(CC)c2",
    "HIT":0.0,
    "question":"Can N(CCNc1cccc(CC)c1)c2cccc(CC)c2 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":4687
  },
  {
    "COADD_ID":"CO-ADD:0223179",
    "INHIB_AVE":10.56,
    "SMILES":"C(=O)(Oc1ccc(cc1OC)\\C=N\\NC(COc2ccccc2C#N)=O)c3ccco3",
    "HIT":0.0,
    "question":"Does the proposed molecule C(=O)(Oc1ccc(cc1OC)\\C=N\\NC(COc2ccccc2C#N)=O)c3ccco3 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":15576
  },
  {
    "COADD_ID":"CO-ADD:0290681",
    "INHIB_AVE":3.42,
    "SMILES":"C(O)(=O)CCSCCCCCCCCCC",
    "HIT":0.0,
    "question":"Is C(O)(=O)CCSCCCCCCCCCC capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":42727
  },
  {
    "COADD_ID":"CO-ADD:0326516",
    "INHIB_AVE":2.1,
    "SMILES":"N1(c2c(cccc2F)F)C(CCCC3=O)=C3C(C(C#N)=C1N)c4ccccc4",
    "HIT":0.0,
    "question":"Can exposure to N1(c2c(cccc2F)F)C(CCCC3=O)=C3C(C(C#N)=C1N)c4ccccc4 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":48625
  },
  {
    "COADD_ID":"CO-ADD:0156944",
    "INHIB_AVE":-3.53,
    "SMILES":"O=C(OCC1=CC=CC=C1)NC(C(OCC(C2=CC=CC=C2)=O)=O)CC(N)=O",
    "HIT":0.0,
    "question":"Does the proposed molecule O=C(OCC1=CC=CC=C1)NC(C(OCC(C2=CC=CC=C2)=O)=O)CC(N)=O exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":68611
  },
  {
    "COADD_ID":"CO-ADD:0218350",
    "INHIB_AVE":2.97,
    "SMILES":"o1c(C)ccc1\\C=N\\NC(=O)c2ccc(cc2)Cl",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound o1c(C)ccc1\\C=N\\NC(=O)c2ccc(cc2)Cl?",
    "answer":"No",
    "_id":44763
  },
  {
    "COADD_ID":"CO-ADD:0153097",
    "INHIB_AVE":11.2,
    "SMILES":"O=C(C1=CC(NC([H])=O)=CN1C)NC2=CN(C(C)C)C(C(NC3=CN(C)C(C(NCCCN(C)C)=O)=C3)=O)=C2.OC(C(F)(F)F)=O",
    "HIT":0.0,
    "question":"Can O=C(C1=CC(NC([H])=O)=CN1C)NC2=CN(C(C)C)C(C(NC3=CN(C)C(C(NCCCN(C)C)=O)=C3)=O)=C2.OC(C(F)(F)F)=O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":14086
  },
  {
    "COADD_ID":"CO-ADD:0292055",
    "INHIB_AVE":3.6,
    "SMILES":"n(c(c1ccc(c(C)c1)C)c2)c3c(c2C(=O)Nc(cc4)ccc4[N+](=O)[O-])cccc3Cl",
    "HIT":0.0,
    "question":"Can n(c(c1ccc(c(C)c1)C)c2)c3c(c2C(=O)Nc(cc4)ccc4[N+](=O)[O-])cccc3Cl act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":41959
  },
  {
    "COADD_ID":"CO-ADD:0293829",
    "INHIB_AVE":4.46,
    "SMILES":"c1(SCC)nc(c2n1CC(=O)Nc3ccccc3CC)cccc2",
    "HIT":0.0,
    "question":"Does c1(SCC)nc(c2n1CC(=O)Nc3ccccc3CC)cccc2 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":38094
  },
  {
    "COADD_ID":"CO-ADD:0219808",
    "INHIB_AVE":5.08,
    "SMILES":"S(=O)(=O)(NOCCC)c1ccccc1[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Can S(=O)(=O)(NOCCC)c1ccccc1[N+](=O)[O-] effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":35277
  },
  {
    "COADD_ID":"CO-ADD:0287140",
    "INHIB_AVE":4.63,
    "SMILES":"c(C(=O)N(CC)CC)(c1C)c(Cl)nc(Cl)c1[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Is c(C(=O)N(CC)CC)(c1C)c(Cl)nc(Cl)c1[N+](=O)[O-] effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":37332
  },
  {
    "COADD_ID":"CO-ADD:0231127",
    "INHIB_AVE":5.07,
    "SMILES":"[N+](=O)([O-])c(ccc(c1NC(=O)C\\C(\\C)=N\\NC(COc2ccc(cc2Br)C)=O)C)c1",
    "HIT":0.0,
    "question":"Is [N+](=O)([O-])c(ccc(c1NC(=O)C\\C(\\C)=N\\NC(COc2ccc(cc2Br)C)=O)C)c1 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":35316
  },
  {
    "COADD_ID":"CO-ADD:0250129",
    "INHIB_AVE":-2.48,
    "SMILES":"C(=O)(N\\N=C\\c1cc(Br)ccc1OC)C(=O)Nc(cccc2C(F)(F)F)c2",
    "HIT":0.0,
    "question":"Does C(=O)(N\\N=C\\c1cc(Br)ccc1OC)C(=O)Nc(cccc2C(F)(F)F)c2 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":65756
  },
  {
    "COADD_ID":"CO-ADD:0253109",
    "INHIB_AVE":1.07,
    "SMILES":"c1(SCC(OCC(=O)Nc(cc2)ccc2C)=O)nc(C)cc(C)n1",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(SCC(OCC(=O)Nc(cc2)ccc2C)=O)nc(C)cc(C)n1?",
    "answer":"No",
    "_id":53143
  },
  {
    "COADD_ID":"CO-ADD:0332629",
    "INHIB_AVE":9.01,
    "SMILES":"C(C(=O)OC(C)C)(=C(C)NC(=C12)CC(CC1=O)c3cccs3)C2c4cc(Br)ccc4F",
    "HIT":0.0,
    "question":"Does C(C(=O)OC(C)C)(=C(C)NC(=C12)CC(CC1=O)c3cccs3)C2c4cc(Br)ccc4F demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":19861
  },
  {
    "COADD_ID":"CO-ADD:0305516",
    "INHIB_AVE":-6.6,
    "SMILES":"c1(cc(C)c(cc1N(CC2)CCN2C)N)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Is c1(cc(C)c(cc1N(CC2)CCN2C)N)[N+](=O)[O-] effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":74737
  },
  {
    "COADD_ID":"CO-ADD:0227392",
    "INHIB_AVE":6.42,
    "SMILES":"c1(c(Br)cc(cc1\\C=N\\NC(CNC(=O)c2ccccc2Br)=O)Br)OC(=O)c3cccc(C)c3",
    "HIT":0.0,
    "question":"Is c1(c(Br)cc(cc1\\C=N\\NC(CNC(=O)c2ccccc2Br)=O)Br)OC(=O)c3cccc(C)c3 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":29430
  },
  {
    "COADD_ID":"CO-ADD:0236498",
    "INHIB_AVE":-4.66,
    "SMILES":"C1(C(=O)NNC(=O)c2ccc(cc2)Br)=Cc3c(OC1=O)ccc(OC)c3",
    "HIT":0.0,
    "question":"Does the proposed molecule C1(C(=O)NNC(=O)c2ccc(cc2)Br)=Cc3c(OC1=O)ccc(OC)c3 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":71158
  },
  {
    "COADD_ID":"CO-ADD:0247547",
    "INHIB_AVE":-9.58,
    "SMILES":"c1(SC(C)C(=O)Nc2c(C)cc(cc2C)C)sc3c(ccc(c3)NC(=O)c4cccc(cccc5)c45)n1",
    "HIT":0.0,
    "question":"Does treatment with c1(SC(C)C(=O)Nc2c(C)cc(cc2C)C)sc3c(ccc(c3)NC(=O)c4cccc(cccc5)c45)n1 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":78376
  },
  {
    "COADD_ID":"CO-ADD:0279131",
    "INHIB_AVE":-14.6,
    "SMILES":"C(C(OCC)=O)(C1c2ccc(cc2)F)=C(Nc3ccccc3)CC(C)(O)C1C(OCC)=O",
    "HIT":0.0,
    "question":"Can C(C(OCC)=O)(C1c2ccc(cc2)F)=C(Nc3ccccc3)CC(C)(O)C1C(OCC)=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":81170
  },
  {
    "COADD_ID":"CO-ADD:0249058",
    "INHIB_AVE":2.64,
    "SMILES":"C12=C(CC(C)(C)CC1=O)c3c(ccc(cccc4)c34)NC2c5cc(OC)c(cc5Br)O",
    "HIT":0.0,
    "question":"Is C12=C(CC(C)(C)CC1=O)c3c(ccc(cccc4)c34)NC2c5cc(OC)c(cc5Br)O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":46229
  },
  {
    "COADD_ID":"CO-ADD:0327385",
    "INHIB_AVE":26.83,
    "SMILES":"C12=C(CC(C)(C)CC1=O)Nc(c3NC2c4ccc(C)o4)cc(c(C)c3)C",
    "HIT":0.0,
    "question":"Can C12=C(CC(C)(C)CC1=O)Nc(c3NC2c4ccc(C)o4)cc(c(C)c3)C act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":959
  },
  {
    "COADD_ID":"CO-ADD:0246177",
    "INHIB_AVE":3.97,
    "SMILES":"C(=C\\c(cccn1)c1)(\/C2=O)\\C(N(CC3)CCO3)=NN2c(cc4)ccc4[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Is C(=C\\c(cccn1)c1)(\/C2=O)\\C(N(CC3)CCO3)=NN2c(cc4)ccc4[N+](=O)[O-] effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":40307
  },
  {
    "COADD_ID":"CO-ADD:0222513",
    "INHIB_AVE":6.33,
    "SMILES":"C(=N\\NC(CNC(=O)c1ccc(c(OC)c1)OC)=O)(\/C2=O)\\c3c(N2)ccc(c3)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Is C(=N\\NC(CNC(=O)c1ccc(c(OC)c1)OC)=O)(\/C2=O)\\c3c(N2)ccc(c3)[N+](=O)[O-] capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":29867
  },
  {
    "COADD_ID":"CO-ADD:0164781",
    "INHIB_AVE":-0.55,
    "SMILES":"CCCc1c(OCCCCc2nn[nH]n2)ccc(C(C)=O)c1O",
    "HIT":0.0,
    "question":"Can CCCc1c(OCCCCc2nn[nH]n2)ccc(C(C)=O)c1O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":59558
  },
  {
    "COADD_ID":"CO-ADD:0287631",
    "INHIB_AVE":1.78,
    "SMILES":"C(CO)(CO)(CO)c1ccccn1",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C(CO)(CO)(CO)c1ccccn1?",
    "answer":"No",
    "_id":50104
  },
  {
    "COADD_ID":"CO-ADD:0218270",
    "INHIB_AVE":-0.62,
    "SMILES":"C(=O)(N\\N=C\\c(cc1)ccc1Br)c2cccc(C)c2",
    "HIT":0.0,
    "question":"Does C(=O)(N\\N=C\\c(cc1)ccc1Br)c2cccc(C)c2 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":59821
  },
  {
    "COADD_ID":"CO-ADD:0255796",
    "INHIB_AVE":7.65,
    "SMILES":"C1(C(OCCOc2ccccc2)=O)=C(C)NC(=O)NC1c3ccc(cc3)O",
    "HIT":0.0,
    "question":"Is C1(C(OCCOc2ccccc2)=O)=C(C)NC(=O)NC1c3ccc(cc3)O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":24469
  },
  {
    "COADD_ID":"CO-ADD:0292557",
    "INHIB_AVE":14.03,
    "SMILES":"c1(nc(Nc2ccccc2)c(n3)Nc4ccccc4F)c3non1",
    "HIT":0.0,
    "question":"Is c1(nc(Nc2ccccc2)c(n3)Nc4ccccc4F)c3non1 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":8983
  },
  {
    "COADD_ID":"CO-ADD:0286242",
    "INHIB_AVE":-3.04,
    "SMILES":"c(C(=O)c1ccc(cc1)Cl)(sc(c23)nc(c(C#N)c2c4ccc(cc4)OCC)N)c3N",
    "HIT":0.0,
    "question":"Is c(C(=O)c1ccc(cc1)Cl)(sc(c23)nc(c(C#N)c2c4ccc(cc4)OCC)N)c3N effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":67332
  },
  {
    "COADD_ID":"CO-ADD:0248925",
    "INHIB_AVE":7.74,
    "SMILES":"N1(c2ccccc2[N+](=O)[O-])C(=O)C(C(C1=O)C34\\C=N\\c5cccc(Cl)c5Cl)C(c(c36)cccc6)c(c47)cccc7",
    "HIT":0.0,
    "question":"Does N1(c2ccccc2[N+](=O)[O-])C(=O)C(C(C1=O)C34\\C=N\\c5cccc(Cl)c5Cl)C(c(c36)cccc6)c(c47)cccc7 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":24182
  },
  {
    "COADD_ID":"CO-ADD:0135147",
    "INHIB_AVE":7.33,
    "SMILES":"Cc1nc(OC)c2n(cc([N+](=O)[O-])n2)c1",
    "HIT":0.0,
    "question":"Does the proposed molecule Cc1nc(OC)c2n(cc([N+](=O)[O-])n2)c1 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":25745
  },
  {
    "COADD_ID":"CO-ADD:0295406",
    "INHIB_AVE":-10.47,
    "SMILES":"c1(OC(N)=C(C2c3ccc(c(OC)c3)OC)C#N)c2c(n[nH]1)CC",
    "HIT":0.0,
    "question":"Is c1(OC(N)=C(C2c3ccc(c(OC)c3)OC)C#N)c2c(n[nH]1)CC effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":79064
  },
  {
    "COADD_ID":"CO-ADD:0220105",
    "INHIB_AVE":3.81,
    "SMILES":"c1c(cccc1Oc(cc2)ccc2N)Oc(cc3)ccc3N",
    "HIT":0.0,
    "question":"Does c1c(cccc1Oc(cc2)ccc2N)Oc(cc3)ccc3N demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":41048
  },
  {
    "COADD_ID":"CO-ADD:0310816",
    "INHIB_AVE":6.84,
    "SMILES":"c1(C(=O)OC(=N2)c(cc3)ccc3C(F)(F)F)c2c4c(cccc4)o1",
    "HIT":0.0,
    "question":"Can c1(C(=O)OC(=N2)c(cc3)ccc3C(F)(F)F)c2c4c(cccc4)o1 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":27658
  },
  {
    "COADD_ID":"CO-ADD:0220265",
    "INHIB_AVE":-0.58,
    "SMILES":"N(=C1c2ccc(cc2)I)\\C(\\C(O1)=O)=C\/c3c(OCC)ccc(cccc4)c34",
    "HIT":0.0,
    "question":"Is N(=C1c2ccc(cc2)I)\\C(\\C(O1)=O)=C\/c3c(OCC)ccc(cccc4)c34 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":59644
  },
  {
    "COADD_ID":"CO-ADD:0299668",
    "INHIB_AVE":-4.38,
    "SMILES":"c12c(ccc(C(O)=O)c1NCCCO)C(=O)c(c3C2=O)cccc3",
    "HIT":0.0,
    "question":"Does c12c(ccc(C(O)=O)c1NCCCO)C(=O)c(c3C2=O)cccc3 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":70579
  },
  {
    "COADD_ID":"CO-ADD:0303249",
    "INHIB_AVE":-6.57,
    "SMILES":"c1(c2c(sc1NC(=O)c3ccccc3C)CCCCC2)C(=O)Nc4ccccc4OCC",
    "HIT":0.0,
    "question":"Can c1(c2c(sc1NC(=O)c3ccccc3C)CCCCC2)C(=O)Nc4ccccc4OCC effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":74676
  },
  {
    "COADD_ID":"CO-ADD:0321134",
    "INHIB_AVE":-3.1,
    "SMILES":"C(=O)(C1CC=CCC1C(O)=O)NC(c2ccccc2)c3ccc(cc3)OC",
    "HIT":0.0,
    "question":"Does the proposed molecule C(=O)(C1CC=CCC1C(O)=O)NC(c2ccccc2)c3ccc(cc3)OC exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":67524
  },
  {
    "COADD_ID":"CO-ADD:0156221",
    "INHIB_AVE":11.5,
    "SMILES":"N#CC1=CC(C2=C3C=CC=C2)=C(C=C3)OC1=N",
    "HIT":0.0,
    "question":"Does the proposed molecule N#CC1=CC(C2=C3C=CC=C2)=C(C=C3)OC1=N exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":13449
  },
  {
    "COADD_ID":"CO-ADD:0243550",
    "INHIB_AVE":15.86,
    "SMILES":"c(OCO1)(c1c2OC)cc(\\C=C(\\c(cc(OC)c(OCO3)c34)c4)\/C#N)c2",
    "HIT":0.0,
    "question":"Can c(OCO1)(c1c2OC)cc(\\C=C(\\c(cc(OC)c(OCO3)c34)c4)\/C#N)c2 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":6515
  },
  {
    "COADD_ID":"CO-ADD:0245903",
    "INHIB_AVE":-3.82,
    "SMILES":"C12(OC(C)=O)CC(c3c(cccc3)O1)N(CC2(C)OC(C)=O)CCC(c4ccccc4)=O",
    "HIT":0.0,
    "question":"Can C12(OC(C)=O)CC(c3c(cccc3)O1)N(CC2(C)OC(C)=O)CCC(c4ccccc4)=O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":69327
  },
  {
    "COADD_ID":"CO-ADD:0283756",
    "INHIB_AVE":4.62,
    "SMILES":"c12c(nc3c(cccc3)n1)c(nn2c4ccc(cc4)C)c5ccccc5",
    "HIT":0.0,
    "question":"Does c12c(nc3c(cccc3)n1)c(nn2c4ccc(cc4)C)c5ccccc5 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":37355
  },
  {
    "COADD_ID":"CO-ADD:0253426",
    "INHIB_AVE":1.27,
    "SMILES":"n1c(c2ccccc2)c[nH]c1SCC(=O)Nc3cccc(C)c3C",
    "HIT":0.0,
    "question":"Is n1c(c2ccccc2)c[nH]c1SCC(=O)Nc3cccc(C)c3C effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":52298
  },
  {
    "COADD_ID":"CO-ADD:0307612",
    "INHIB_AVE":-11.84,
    "SMILES":"C(=O)(N(CC1)CCN1c2ccc(cc2F)C(CCC)=O)c3ccccc3Br",
    "HIT":0.0,
    "question":"Can exposure to C(=O)(N(CC1)CCN1c2ccc(cc2F)C(CCC)=O)c3ccccc3Br lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":79934
  },
  {
    "COADD_ID":"CO-ADD:0234077",
    "INHIB_AVE":10.18,
    "SMILES":"c1(NC(=O)Nc2c(F)c(F)c(c(F)c2F)F)c(F)c(F)c(c(F)c1F)F",
    "HIT":0.0,
    "question":"Does c1(NC(=O)Nc2c(F)c(F)c(c(F)c2F)F)c(F)c(F)c(c(F)c1F)F show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":16543
  },
  {
    "COADD_ID":"CO-ADD:0245049",
    "INHIB_AVE":10.78,
    "SMILES":"c1(c(Br)cc(c(c1)NC(=O)c2ccccc2F)Br)C(F)(F)F",
    "HIT":0.0,
    "question":"Can c1(c(Br)cc(c(c1)NC(=O)c2ccccc2F)Br)C(F)(F)F effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":15040
  },
  {
    "COADD_ID":"CO-ADD:0223787",
    "INHIB_AVE":-0.83,
    "SMILES":"C(=O)(Nc1ccccc1C)c2ccccc2OC",
    "HIT":0.0,
    "question":"Does C(=O)(Nc1ccccc1C)c2ccccc2OC demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":60530
  },
  {
    "COADD_ID":"CO-ADD:0256618",
    "INHIB_AVE":2.66,
    "SMILES":"C(C(OC)=O)(=C1C)\\C(=C\\c2ccc(cc2Cl)Cl)\\C(N1CCOC)=O",
    "HIT":0.0,
    "question":"Is C(C(OC)=O)(=C1C)\\C(=C\\c2ccc(cc2Cl)Cl)\\C(N1CCOC)=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":46175
  },
  {
    "COADD_ID":"CO-ADD:0306866",
    "INHIB_AVE":-1.53,
    "SMILES":"C12(c3c(N(CC(OC)=O)C1=O)cccc3)C(C#N)=C(N)Oc([nH]nc4c5ccc(cc5)OCCCC)c24",
    "HIT":0.0,
    "question":"Is C12(c3c(N(CC(OC)=O)C1=O)cccc3)C(C#N)=C(N)Oc([nH]nc4c5ccc(cc5)OCCCC)c24 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":62821
  },
  {
    "COADD_ID":"CO-ADD:0299561",
    "INHIB_AVE":-0.36,
    "SMILES":"C(=O)(CN(CC1)CCO1)N\\N=C\\c2ccccc2O",
    "HIT":0.0,
    "question":"Does the proposed molecule C(=O)(CN(CC1)CCO1)N\\N=C\\c2ccccc2O exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":58849
  },
  {
    "COADD_ID":"CO-ADD:0312189",
    "INHIB_AVE":-1.6,
    "SMILES":"n(c(c(cc1)ccc1[N+](=O)[O-])nn2CC(=O)Nc3ccc(cc3C)C)c2SCC(=O)Nc4ccc(cc4C)C",
    "HIT":0.0,
    "question":"Does n(c(c(cc1)ccc1[N+](=O)[O-])nn2CC(=O)Nc3ccc(cc3C)C)c2SCC(=O)Nc4ccc(cc4C)C demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":63068
  },
  {
    "COADD_ID":"CO-ADD:0293892",
    "INHIB_AVE":9.43,
    "SMILES":"N1(c2ccc(cc2)OCC)CC(CC1=O)C(=O)NC(CC3(C)C)CC(N3)(C)C",
    "HIT":0.0,
    "question":"Is N1(c2ccc(cc2)OCC)CC(CC1=O)C(=O)NC(CC3(C)C)CC(N3)(C)C capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":18649
  },
  {
    "COADD_ID":"CO-ADD:0246017",
    "INHIB_AVE":10.84,
    "SMILES":"N1(C(=O)c2ccccc2F)C(O)(c3ccc(cc3)Cl)CC(C(F)(F)F)=N1",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound N1(C(=O)c2ccccc2F)C(O)(c3ccc(cc3)Cl)CC(C(F)(F)F)=N1?",
    "answer":"No",
    "_id":14900
  },
  {
    "COADD_ID":"CO-ADD:0255273",
    "INHIB_AVE":4.7,
    "SMILES":"C(C(OCCOc1ccccc1)=O)(=C(C)NC(=C23)CC(CC2=O)(C)C)C3c4ccccc4F",
    "HIT":0.0,
    "question":"Can exposure to C(C(OCCOc1ccccc1)=O)(=C(C)NC(=C23)CC(CC2=O)(C)C)C3c4ccccc4F lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":36992
  },
  {
    "COADD_ID":"CO-ADD:0332599",
    "INHIB_AVE":5.24,
    "SMILES":"C(=O)(NC(=S)Nc(cc1)ccc1C(=O)OC(C)C)c2cc(Cl)ccc2OC",
    "HIT":0.0,
    "question":"Does C(=O)(NC(=S)Nc(cc1)ccc1C(=O)OC(C)C)c2cc(Cl)ccc2OC demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":34559
  },
  {
    "COADD_ID":"CO-ADD:0291452",
    "INHIB_AVE":-6.35,
    "SMILES":"C(\/c1c(N2CCCCCC)cccc1)(\\C2=O)=C(\\SC(N3NC(c4ccccc4)=O)=S)\/C3=O",
    "HIT":0.0,
    "question":"Can C(\/c1c(N2CCCCCC)cccc1)(\\C2=O)=C(\\SC(N3NC(c4ccccc4)=O)=S)\/C3=O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":74321
  },
  {
    "COADD_ID":"CO-ADD:0159994",
    "INHIB_AVE":0.22,
    "SMILES":"O=C(S\/1)N(CNC2=CC=CC(C(F)(F)F)=C2)C(C1=C\\C3=CC=CC=C3)=O",
    "HIT":0.0,
    "question":"Can exposure to O=C(S\/1)N(CNC2=CC=CC(C(F)(F)F)=C2)C(C1=C\\C3=CC=CC=C3)=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":56588
  },
  {
    "COADD_ID":"CO-ADD:0231594",
    "INHIB_AVE":6.48,
    "SMILES":"n1c2c(oc1c3ccc(cc3)OC)ccc(c2)\\N=C\\c(cc(Cl)cc4Cl)c4O",
    "HIT":0.0,
    "question":"Does n1c2c(oc1c3ccc(cc3)OC)ccc(c2)\\N=C\\c(cc(Cl)cc4Cl)c4O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":29197
  },
  {
    "COADD_ID":"CO-ADD:0245867",
    "INHIB_AVE":-1.02,
    "SMILES":"c1(OCC(=O)N\\N=C\\C=N\\NC(COc2c(Br)cc(cc2Br)C)=O)c(Br)cc(cc1Br)C",
    "HIT":0.0,
    "question":"Does c1(OCC(=O)N\\N=C\\C=N\\NC(COc2c(Br)cc(cc2Br)C)=O)c(Br)cc(cc1Br)C demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":61185
  },
  {
    "COADD_ID":"CO-ADD:0320126",
    "INHIB_AVE":-6.38,
    "SMILES":"n1(CC(=O)N(CC)C2(CCCCC2)C(=O)Nc(cc3)ccc3C)nnnc1N",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound n1(CC(=O)N(CC)C2(CCCCC2)C(=O)Nc(cc3)ccc3C)nnnc1N?",
    "answer":"No",
    "_id":74376
  },
  {
    "COADD_ID":"CO-ADD:0311494",
    "INHIB_AVE":-1.65,
    "SMILES":"C1(=NCC(C)(C)S1)N(c2ccc(cc2)OC(F)(F)Cl)C(=O)Nc(cc3)ccc3Cl",
    "HIT":0.0,
    "question":"Does C1(=NCC(C)(C)S1)N(c2ccc(cc2)OC(F)(F)Cl)C(=O)Nc(cc3)ccc3Cl show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":63267
  },
  {
    "COADD_ID":"CO-ADD:0259605",
    "INHIB_AVE":-5.9,
    "SMILES":"c1(SCc2ccccc2)sc3c(ccc(c3)NC(=O)c4ccccc4OC)n1",
    "HIT":0.0,
    "question":"Does treatment with c1(SCc2ccccc2)sc3c(ccc(c3)NC(=O)c4ccccc4OC)n1 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":73539
  },
  {
    "COADD_ID":"CO-ADD:0286502",
    "INHIB_AVE":-2.92,
    "SMILES":"C(\/c1c(N2Cc3c(cccc3Cl)Cl)cccc1)(=N\/N(C)C(NC)=S)\\C2=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C(\/c1c(N2Cc3c(cccc3Cl)Cl)cccc1)(=N\/N(C)C(NC)=S)\\C2=O?",
    "answer":"No",
    "_id":67027
  },
  {
    "COADD_ID":"CO-ADD:0293976",
    "INHIB_AVE":-10.01,
    "SMILES":"c1(NC(=O)c2ccccc2F)n(c3ccccc3)ncc1C(=O)N4CCC(CC4)C(N)=O",
    "HIT":0.0,
    "question":"Can c1(NC(=O)c2ccccc2F)n(c3ccccc3)ncc1C(=O)N4CCC(CC4)C(N)=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":78709
  },
  {
    "COADD_ID":"CO-ADD:0303196",
    "INHIB_AVE":8.44,
    "SMILES":"[n+]1([O-])onc2c1ccc(c2)OC",
    "HIT":0.0,
    "question":"Does [n+]1([O-])onc2c1ccc(c2)OC demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":21654
  },
  {
    "COADD_ID":"CO-ADD:0256989",
    "INHIB_AVE":1.29,
    "SMILES":"c(CC(C(NCCCl)=O)NC(OCc1ccccc1)=O)(c2c([nH]3)cccc2)c3",
    "HIT":0.0,
    "question":"Does the proposed molecule c(CC(C(NCCCl)=O)NC(OCc1ccccc1)=O)(c2c([nH]3)cccc2)c3 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":52218
  },
  {
    "COADD_ID":"CO-ADD:0257724",
    "INHIB_AVE":-4.34,
    "SMILES":"C(NCC=C)(=O)C(NCCCCCCCCCCCC)=O",
    "HIT":0.0,
    "question":"Is C(NCC=C)(=O)C(NCCCCCCCCCCCC)=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":70496
  },
  {
    "COADD_ID":"CO-ADD:0301750",
    "INHIB_AVE":12.61,
    "SMILES":"n1c(ccc(c23)cccc2)c3c4c(CCC4)c1c(cccc5[N+](=O)[O-])c5.Cl",
    "HIT":0.0,
    "question":"Can n1c(ccc(c23)cccc2)c3c4c(CCC4)c1c(cccc5[N+](=O)[O-])c5.Cl act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":11281
  },
  {
    "COADD_ID":"CO-ADD:0324797",
    "INHIB_AVE":-11.79,
    "SMILES":"C1(=O)N(CCCC)c2c(Oc(cc(cc3Oc(cc4)ccc4Cl)[N+](=O)[O-])c13)cccc2",
    "HIT":0.0,
    "question":"Can C1(=O)N(CCCC)c2c(Oc(cc(cc3Oc(cc4)ccc4Cl)[N+](=O)[O-])c13)cccc2 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":79905
  },
  {
    "COADD_ID":"CO-ADD:0253349",
    "INHIB_AVE":3.92,
    "SMILES":"C1(c2cc(I)ccc2Cl)=N\\C(\\C(=O)N1)=C\\c3ccco3",
    "HIT":0.0,
    "question":"Does treatment with C1(c2cc(I)ccc2Cl)=N\\C(\\C(=O)N1)=C\\c3ccco3 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":40507
  },
  {
    "COADD_ID":"CO-ADD:0247599",
    "INHIB_AVE":10.31,
    "SMILES":"C(C(OCC)=O)(C1c2cccs2)=C(N)N(C(CC(C)(C)CC3=O)=C13)c(cc4)ccc4[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Can exposure to C(C(OCC)=O)(C1c2cccs2)=C(N)N(C(CC(C)(C)CC3=O)=C13)c(cc4)ccc4[N+](=O)[O-] lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":16218
  },
  {
    "COADD_ID":"CO-ADD:0253051",
    "INHIB_AVE":-2.54,
    "SMILES":"c1(cnn(C)c1C(=O)Nc(cc2)ccc2NC(C)=O)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Is c1(cnn(C)c1C(=O)Nc(cc2)ccc2NC(C)=O)[N+](=O)[O-] capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":65918
  },
  {
    "COADD_ID":"CO-ADD:0246125",
    "INHIB_AVE":1.5,
    "SMILES":"n1c(c2ccc(cc2)C)c(cn1c3ccccc3)\\C=N\\NC(COc4ccc(cc4Cl)Cl)=O",
    "HIT":0.0,
    "question":"Can n1c(c2ccc(cc2)C)c(cn1c3ccccc3)\\C=N\\NC(COc4ccc(cc4Cl)Cl)=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":51294
  },
  {
    "COADD_ID":"CO-ADD:0240210",
    "INHIB_AVE":20.46,
    "SMILES":"c(\\C=C\\C(=O)c1ccc(cc1Cl)Cl)(c2C)c(C)n(n2)C",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c(\\C=C\\C(=O)c1ccc(cc1Cl)Cl)(c2C)c(C)n(n2)C?",
    "answer":"No",
    "_id":2620
  },
  {
    "COADD_ID":"CO-ADD:0159798",
    "INHIB_AVE":0.27,
    "SMILES":"C1(N2CCCCC2)=NC(N\/N=C\/C3=C(C=CC=C4)C4=CC5=CC=CC=C35)=NC(N6CCCCC6)=N1",
    "HIT":0.0,
    "question":"Does C1(N2CCCCC2)=NC(N\/N=C\/C3=C(C=CC=C4)C4=CC5=CC=CC=C35)=NC(N6CCCCC6)=N1 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":56374
  },
  {
    "COADD_ID":"CO-ADD:0302619",
    "INHIB_AVE":-3.11,
    "SMILES":"N1(c2ccc(cc2)C)C(\\C=C\\c(cc3)ccc3OC)=Nc(c4C1=O)cccc4",
    "HIT":0.0,
    "question":"Can exposure to N1(c2ccc(cc2)C)C(\\C=C\\c(cc3)ccc3OC)=Nc(c4C1=O)cccc4 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":67532
  },
  {
    "COADD_ID":"CO-ADD:0331389",
    "INHIB_AVE":6.62,
    "SMILES":"n1(CC(C)C)c2c(nc1COc3ccc(cc3Cl)Cl)cccc2",
    "HIT":0.0,
    "question":"Can n1(CC(C)C)c2c(nc1COc3ccc(cc3Cl)Cl)cccc2 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":28619
  },
  {
    "COADD_ID":"CO-ADD:0230253",
    "INHIB_AVE":10.67,
    "SMILES":"C(OC)(=O)c1ccc(cc1)OCc2ccccc2",
    "HIT":0.0,
    "question":"Does C(OC)(=O)c1ccc(cc1)OCc2ccccc2 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":15285
  },
  {
    "COADD_ID":"CO-ADD:0306350",
    "INHIB_AVE":12.78,
    "SMILES":"C12(C(=O)NCc3ccccc3)C(=NN=CN1)N(C(=O)N2C)C",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C12(C(=O)NCc3ccccc3)C(=NN=CN1)N(C(=O)N2C)C?",
    "answer":"No",
    "_id":10978
  },
  {
    "COADD_ID":"CO-ADD:0285299",
    "INHIB_AVE":12.99,
    "SMILES":"C(C(=O)OC1CCCC1)(=C(C)NC(=C23)CC(CC2=O)c4ccc(cc4)OC)C3c5cc(OC)ccc5OC",
    "HIT":0.0,
    "question":"Is C(C(=O)OC1CCCC1)(=C(C)NC(=C23)CC(CC2=O)c4ccc(cc4)OC)C3c5cc(OC)ccc5OC capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":10587
  },
  {
    "COADD_ID":"CO-ADD:0250050",
    "INHIB_AVE":7.65,
    "SMILES":"C1(NS(CCl)(=O)=O)=C(C)N(N(c2ccccc2)C1=O)C",
    "HIT":0.0,
    "question":"Does C1(NS(CCl)(=O)=O)=C(C)N(N(c2ccccc2)C1=O)C show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":24471
  },
  {
    "COADD_ID":"CO-ADD:0324917",
    "INHIB_AVE":1.14,
    "SMILES":"n1(n2)c(nc(cc1C(F)(F)Cl)c3ccco3)cc2C(=O)N(CC4)CCO4",
    "HIT":0.0,
    "question":"Can n1(n2)c(nc(cc1C(F)(F)Cl)c3ccco3)cc2C(=O)N(CC4)CCO4 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":52914
  },
  {
    "COADD_ID":"CO-ADD:0220866",
    "INHIB_AVE":6.33,
    "SMILES":"c1(ccc(cc1Cl)Cl)C(=O)Nc(cc2)ccc2C(=O)Nc3ccc(cc3C)Cl",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(ccc(cc1Cl)Cl)C(=O)Nc(cc2)ccc2C(=O)Nc3ccc(cc3C)Cl?",
    "answer":"No",
    "_id":29839
  },
  {
    "COADD_ID":"CO-ADD:0258983",
    "INHIB_AVE":2.52,
    "SMILES":"c1(c(O)c(\\C=N\\NC(=O)Nc2ccccc2)cc(c1)[N+](=O)[O-])[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Does treatment with c1(c(O)c(\\C=N\\NC(=O)Nc2ccccc2)cc(c1)[N+](=O)[O-])[N+](=O)[O-] result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":46800
  },
  {
    "COADD_ID":"CO-ADD:0320756",
    "INHIB_AVE":12.43,
    "SMILES":"S(=O)(=O)(c1ccc(cc1)OC)N2CCc(c3C2C(O)=O)cccc3",
    "HIT":0.0,
    "question":"Can S(=O)(=O)(c1ccc(cc1)OC)N2CCc(c3C2C(O)=O)cccc3 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":11600
  },
  {
    "COADD_ID":"CO-ADD:0318818",
    "INHIB_AVE":9.23,
    "SMILES":"c1(NC(C2CCCC2)=O)sc(c3c1C(OC)=O)CCCC3",
    "HIT":0.0,
    "question":"Can c1(NC(C2CCCC2)=O)sc(c3c1C(OC)=O)CCCC3 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":19249
  },
  {
    "COADD_ID":"CO-ADD:0242508",
    "INHIB_AVE":22.92,
    "SMILES":"N(\/NC(COc1ccccc1)=O)=C(\\C(C)C)\/c2ccccc2",
    "HIT":0.0,
    "question":"Does N(\/NC(COc1ccccc1)=O)=C(\\C(C)C)\/c2ccccc2 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":1641
  },
  {
    "COADD_ID":"CO-ADD:0252747",
    "INHIB_AVE":10.38,
    "SMILES":"N1(C(CC)=O)N=C(CC1(O)c2ccccc2)C",
    "HIT":0.0,
    "question":"Does N1(C(CC)=O)N=C(CC1(O)c2ccccc2)C demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":16043
  },
  {
    "COADD_ID":"CO-ADD:0332481",
    "INHIB_AVE":6.62,
    "SMILES":"C(=N\\c(cc1)ccc1C(=O)NCc2ccccc2)(\/c3c(N4)cccc3)\\C4=O",
    "HIT":0.0,
    "question":"Does the proposed molecule C(=N\\c(cc1)ccc1C(=O)NCc2ccccc2)(\/c3c(N4)cccc3)\\C4=O exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":28627
  },
  {
    "COADD_ID":"CO-ADD:0328820",
    "INHIB_AVE":7.1,
    "SMILES":"N12C(SC(C(F)(F)F)=N1)=NC(=O)\\C(=C\\c(cc3OC)cc(c3OCc4ccccc4)Cl)\\C2=N",
    "HIT":0.0,
    "question":"Is N12C(SC(C(F)(F)F)=N1)=NC(=O)\\C(=C\\c(cc3OC)cc(c3OCc4ccccc4)Cl)\\C2=N capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":26596
  },
  {
    "COADD_ID":"CO-ADD:0253584",
    "INHIB_AVE":-32.16,
    "SMILES":"c1(Nc(ccc(c2F)C)c2)c(cc(cc1[N+](=O)[O-])C(=O)Nc(cc3)ccc3C(OCC)=O)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Is c1(Nc(ccc(c2F)C)c2)c(cc(cc1[N+](=O)[O-])C(=O)Nc(cc3)ccc3C(OCC)=O)[N+](=O)[O-] capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":82622
  },
  {
    "COADD_ID":"CO-ADD:0155800",
    "INHIB_AVE":3.64,
    "SMILES":"O=C(N(C1=CC=CC=C1)CCN(C2=CC=CC=C2)C(C3C4CCCCC34)=O)C5C6CCCCC56",
    "HIT":0.0,
    "question":"Does O=C(N(C1=CC=CC=C1)CCN(C2=CC=CC=C2)C(C3C4CCCCC34)=O)C5C6CCCCC56 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":41804
  },
  {
    "COADD_ID":"CO-ADD:0249902",
    "INHIB_AVE":-27.96,
    "SMILES":"N1(c2ccccc2F)C(=O)C(CC1=O)SCC(=O)Nc3cccc(Cl)c3",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound N1(c2ccccc2F)C(=O)C(CC1=O)SCC(=O)Nc3cccc(Cl)c3?",
    "answer":"No",
    "_id":82555
  },
  {
    "COADD_ID":"CO-ADD:0291291",
    "INHIB_AVE":-9.87,
    "SMILES":"C12(c3ccccc3)C(C(C(=O)N1Cc4ccccc4)=O)=C(c5ccccc5)Nc(cccc6)c6N2",
    "HIT":0.0,
    "question":"Can C12(c3ccccc3)C(C(C(=O)N1Cc4ccccc4)=O)=C(c5ccccc5)Nc(cccc6)c6N2 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":78615
  },
  {
    "COADD_ID":"CO-ADD:0227628",
    "INHIB_AVE":6.52,
    "SMILES":"n1c2c(oc1c3ccc(cc3)\\N=C\\c4cccc(F)c4O)ccc(Cl)c2",
    "HIT":0.0,
    "question":"Is n1c2c(oc1c3ccc(cc3)\\N=C\\c4cccc(F)c4O)ccc(Cl)c2 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":29048
  },
  {
    "COADD_ID":"CO-ADD:0225554",
    "INHIB_AVE":5.11,
    "SMILES":"N12C(C=CC(C(=O)Nc(cc3)ccc3OC)=C1)=NN(CC(=O)Nc(cc4)ccc4C(C)C)C2=O",
    "HIT":0.0,
    "question":"Can exposure to N12C(C=CC(C(=O)Nc(cc3)ccc3OC)=C1)=NN(CC(=O)Nc(cc4)ccc4C(C)C)C2=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":35146
  },
  {
    "COADD_ID":"CO-ADD:0136696",
    "INHIB_AVE":3.14,
    "SMILES":"n1(c(c(cccc2)c2)ccc1c(cccc3)c3)c(ccc4)c(O)c4",
    "HIT":0.0,
    "question":"Does n1(c(c(cccc2)c2)ccc1c(cccc3)c3)c(ccc4)c(O)c4 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":43979
  },
  {
    "COADD_ID":"CO-ADD:0233608",
    "INHIB_AVE":15.26,
    "SMILES":"C(c1ccccc1)(=O)NCc2ccco2",
    "HIT":0.0,
    "question":"Is C(c1ccccc1)(=O)NCc2ccco2 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":7249
  },
  {
    "COADD_ID":"CO-ADD:0306919",
    "INHIB_AVE":3.16,
    "SMILES":"c1(noc(COc2c(F)c(F)cc(F)c2F)n1)c3nonc3N",
    "HIT":0.0,
    "question":"Is c1(noc(COc2c(F)c(F)cc(F)c2F)n1)c3nonc3N effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":43907
  },
  {
    "COADD_ID":"CO-ADD:0319149",
    "INHIB_AVE":6.7,
    "SMILES":"c1(NC(CSc2[nH]c(c3n2)ccc(C)c3)=O)nonc1N",
    "HIT":0.0,
    "question":"Does the proposed molecule c1(NC(CSc2[nH]c(c3n2)ccc(C)c3)=O)nonc1N exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":28292
  },
  {
    "COADD_ID":"CO-ADD:0158697",
    "INHIB_AVE":7.03,
    "SMILES":"[O-][N+](C(C=C1)=CC=C1C(OC(C=C2)=C(OCC)C=C2\/C=N\/NC(COC(C(Br)=C3)=CC=C3OC)=O)=O)=O",
    "HIT":0.0,
    "question":"Does the proposed molecule [O-][N+](C(C=C1)=CC=C1C(OC(C=C2)=C(OCC)C=C2\/C=N\/NC(COC(C(Br)=C3)=CC=C3OC)=O)=O)=O exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":26863
  },
  {
    "COADD_ID":"CO-ADD:0252267",
    "INHIB_AVE":0.0,
    "SMILES":"c1(C#N)c(CCC(C2)C(C)(C)C)c2sc1\\N=C\\c(cccn3)c3",
    "HIT":0.0,
    "question":"Does the proposed molecule c1(C#N)c(CCC(C2)C(C)(C)C)c2sc1\\N=C\\c(cccn3)c3 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":82757
  },
  {
    "COADD_ID":"CO-ADD:0246181",
    "INHIB_AVE":-7.71,
    "SMILES":"N1(c2ccccc2[N+](=O)[O-])C(=O)C(C(C1=O)C34\\C=N\\c5cccc(C)c5C)C(c(c36)cccc6)c(c47)cccc7",
    "HIT":0.0,
    "question":"Is N1(c2ccccc2[N+](=O)[O-])C(=O)C(C(C1=O)C34\\C=N\\c5cccc(C)c5C)C(c(c36)cccc6)c(c47)cccc7 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":76353
  },
  {
    "COADD_ID":"CO-ADD:0277856",
    "INHIB_AVE":-5.84,
    "SMILES":"N1(C2c3c(OC)ccc(cccc4)c34)C(S\\C(=C\\c5ccccc5OC)\\C1=O)=NC(c6ccccc6)=C2C(OCC)=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound N1(C2c3c(OC)ccc(cccc4)c34)C(S\\C(=C\\c5ccccc5OC)\\C1=O)=NC(c6ccccc6)=C2C(OCC)=O?",
    "answer":"No",
    "_id":73429
  },
  {
    "COADD_ID":"CO-ADD:0299610",
    "INHIB_AVE":-0.43,
    "SMILES":"C(C(C)=O)(C1c2ccc(cc2)Cl)=C(O)C(N1CCN(CC3)CCO3)=O",
    "HIT":0.0,
    "question":"Can C(C(C)=O)(C1c2ccc(cc2)Cl)=C(O)C(N1CCN(CC3)CCO3)=O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":59128
  },
  {
    "COADD_ID":"CO-ADD:0291355",
    "INHIB_AVE":13.09,
    "SMILES":"C12(Nc(cccc3)c3C(=O)N1c(cccc4C(F)(F)F)c4)c5c(N(Cc6c(cccc6Cl)Cl)C2=O)cccc5",
    "HIT":0.0,
    "question":"Does C12(Nc(cccc3)c3C(=O)N1c(cccc4C(F)(F)F)c4)c5c(N(Cc6c(cccc6Cl)Cl)C2=O)cccc5 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":10435
  },
  {
    "COADD_ID":"CO-ADD:0257459",
    "INHIB_AVE":10.0,
    "SMILES":"N1(CN(CC2C)CC(O2)C)C(=O)C=CC(O)=N1",
    "HIT":0.0,
    "question":"Does treatment with N1(CN(CC2C)CC(O2)C)C(=O)C=CC(O)=N1 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":16999
  },
  {
    "COADD_ID":"CO-ADD:0326790",
    "INHIB_AVE":19.16,
    "SMILES":"n1(c(CC)nn2)c2SCC(c3ccc(c(OC)c3)OC)=N1.Br",
    "HIT":0.0,
    "question":"Can n1(c(CC)nn2)c2SCC(c3ccc(c(OC)c3)OC)=N1.Br effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":3409
  },
  {
    "COADD_ID":"CO-ADD:0257321",
    "INHIB_AVE":-8.68,
    "SMILES":"C(=C\\c(ccc1c(ccc(c2C(O)=O)Cl)c2)o1)(\/C(=O)NN3c4ccc(cc4)F)\\C3=O",
    "HIT":0.0,
    "question":"Is C(=C\\c(ccc1c(ccc(c2C(O)=O)Cl)c2)o1)(\/C(=O)NN3c4ccc(cc4)F)\\C3=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":77502
  },
  {
    "COADD_ID":"CO-ADD:0247506",
    "INHIB_AVE":-2.6,
    "SMILES":"N(CCc(c12)cccc1)(Cc(cc3)ccc3C(=O)N\\N=C(\/C)\\c(ccc(c45)OCCO4)c5)C2",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound N(CCc(c12)cccc1)(Cc(cc3)ccc3C(=O)N\\N=C(\/C)\\c(ccc(c45)OCCO4)c5)C2?",
    "answer":"No",
    "_id":66097
  },
  {
    "COADD_ID":"CO-ADD:0260191",
    "INHIB_AVE":0.9,
    "SMILES":"C(=C\\c(cc1OC)cc(c1O)I)(\/C2=O)\\Sc(c23)cccc3",
    "HIT":0.0,
    "question":"Can C(=C\\c(cc1OC)cc(c1O)I)(\/C2=O)\\Sc(c23)cccc3 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":53860
  },
  {
    "COADD_ID":"CO-ADD:0291286",
    "INHIB_AVE":-10.39,
    "SMILES":"n12c(S\\C(=C\/c3c4c([nH]c3C)cccc4)\\C1=O)nc(cc(Br)cn5)c25",
    "HIT":0.0,
    "question":"Is n12c(S\\C(=C\/c3c4c([nH]c3C)cccc4)\\C1=O)nc(cc(Br)cn5)c25 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":78995
  },
  {
    "COADD_ID":"CO-ADD:0286341",
    "INHIB_AVE":-4.19,
    "SMILES":"c1([nH]c(c2n1)ccc(C)c2)\\C(\\C#N)=C\\c(cc3OC)cc(c3OC4=O)S4",
    "HIT":0.0,
    "question":"Can c1([nH]c(c2n1)ccc(C)c2)\\C(\\C#N)=C\\c(cc3OC)cc(c3OC4=O)S4 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":70188
  },
  {
    "COADD_ID":"CO-ADD:0332443",
    "INHIB_AVE":2.15,
    "SMILES":"[N+](=O)([O-])c(ccc(c1C(=O)c2ccc(cc2)C)Cl)c1",
    "HIT":0.0,
    "question":"Can exposure to [N+](=O)([O-])c(ccc(c1C(=O)c2ccc(cc2)C)Cl)c1 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":48424
  },
  {
    "COADD_ID":"CO-ADD:0135143",
    "INHIB_AVE":16.94,
    "SMILES":"Cc1nc(OCCOC(=O)C)c2n(cc([N+](=O)[O-])n2)c1",
    "HIT":0.0,
    "question":"Can Cc1nc(OCCOC(=O)C)c2n(cc([N+](=O)[O-])n2)c1 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":5351
  },
  {
    "COADD_ID":"CO-ADD:0277470",
    "INHIB_AVE":1.99,
    "SMILES":"n1c(c2ccc(cc2)SC)[nH]c(c3ccccc3)c1c4ccc(cc4)Sc5ccccc5",
    "HIT":0.0,
    "question":"Can n1c(c2ccc(cc2)SC)[nH]c(c3ccccc3)c1c4ccc(cc4)Sc5ccccc5 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":49160
  },
  {
    "COADD_ID":"CO-ADD:0278467",
    "INHIB_AVE":-3.95,
    "SMILES":"n1c(c2ccc(cc2C)C)csc1\\C(\\C#N)=N\\Nc(cc3)ccc3C",
    "HIT":0.0,
    "question":"Is n1c(c2ccc(cc2C)C)csc1\\C(\\C#N)=N\\Nc(cc3)ccc3C effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":69627
  },
  {
    "COADD_ID":"CO-ADD:0140026",
    "INHIB_AVE":11.17,
    "SMILES":"CC1=CC=CC=C1NC2=CC=CC=C2C3=CC=C([N+]([O-])=O)C=C3",
    "HIT":0.0,
    "question":"Can CC1=CC=CC=C1NC2=CC=CC=C2C3=CC=C([N+]([O-])=O)C=C3 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":14151
  },
  {
    "COADD_ID":"CO-ADD:0157371",
    "INHIB_AVE":-12.71,
    "SMILES":"[O-][N+](C1=CC(\/C=N\/NC(N\/N=C\/C2=CC=CC([N+]([O-])=O)=C2)=NN)=CC=C1)=O",
    "HIT":0.0,
    "question":"Is [O-][N+](C1=CC(\/C=N\/NC(N\/N=C\/C2=CC=CC([N+]([O-])=O)=C2)=NN)=CC=C1)=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":80410
  },
  {
    "COADD_ID":"CO-ADD:0240853",
    "INHIB_AVE":16.3,
    "SMILES":"[N+](=O)([O-])c1ccc(cc1NCCOc(ccc(c2C)C)c2)N3CCCCC3",
    "HIT":0.0,
    "question":"Can exposure to [N+](=O)([O-])c1ccc(cc1NCCOc(ccc(c2C)C)c2)N3CCCCC3 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":6018
  },
  {
    "COADD_ID":"CO-ADD:0324024",
    "INHIB_AVE":4.3,
    "SMILES":"C1(=Cc2c(OC1=O)ccc(Br)c2)C(=O)Nc3ccccc3NC(=O)c(cc4)ccc4C(F)(F)F",
    "HIT":0.0,
    "question":"Does C1(=Cc2c(OC1=O)ccc(Br)c2)C(=O)Nc3ccccc3NC(=O)c(cc4)ccc4C(F)(F)F demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":38819
  },
  {
    "COADD_ID":"CO-ADD:0301944",
    "INHIB_AVE":2.22,
    "SMILES":"N1(c2ccc(cc2)Cl)C(c3ccccn3)Nc(c4C1=O)cccc4",
    "HIT":0.0,
    "question":"Does the proposed molecule N1(c2ccc(cc2)Cl)C(c3ccccn3)Nc(c4C1=O)cccc4 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":48123
  },
  {
    "COADD_ID":"CO-ADD:0284656",
    "INHIB_AVE":7.34,
    "SMILES":"c(c1c(n2Cc3ccccc3)cccc1)(c2)C4Nc(ccc(c56)cccc5)c6C(CC(C)(C)CC7=O)=C47",
    "HIT":0.0,
    "question":"Can exposure to c(c1c(n2Cc3ccccc3)cccc1)(c2)C4Nc(ccc(c56)cccc5)c6C(CC(C)(C)CC7=O)=C47 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":25717
  },
  {
    "COADD_ID":"CO-ADD:0249199",
    "INHIB_AVE":1.3,
    "SMILES":"N(c1cccc(C)c1)(C(=O)C(C23)NN=C2C(OC)=O)C3=O",
    "HIT":0.0,
    "question":"Is N(c1cccc(C)c1)(C(=O)C(C23)NN=C2C(OC)=O)C3=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":52165
  },
  {
    "COADD_ID":"CO-ADD:0292852",
    "INHIB_AVE":-2.96,
    "SMILES":"S1(=O)(=O)N(C(C)CC)C2C(OC(C(O2)O3)OC(C3N4C(C)CC)N(S4(=O)=O)C(C)CC)N1C(C)CC",
    "HIT":0.0,
    "question":"Can S1(=O)(=O)N(C(C)CC)C2C(OC(C(O2)O3)OC(C3N4C(C)CC)N(S4(=O)=O)C(C)CC)N1C(C)CC effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":67151
  },
  {
    "COADD_ID":"CO-ADD:0229374",
    "INHIB_AVE":-2.07,
    "SMILES":"o1c(S)nnc1c(cc2)ccc2C(C)(C)C",
    "HIT":0.0,
    "question":"Does o1c(S)nnc1c(cc2)ccc2C(C)(C)C demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":64556
  },
  {
    "COADD_ID":"CO-ADD:0247676",
    "INHIB_AVE":7.35,
    "SMILES":"C(CCC#N)(CCC#N)(C(C)=O)C(CCC#N)(CCC#N)C(C)=O",
    "HIT":0.0,
    "question":"Is C(CCC#N)(CCC#N)(C(C)=O)C(CCC#N)(CCC#N)C(C)=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":25676
  },
  {
    "COADD_ID":"CO-ADD:0323621",
    "INHIB_AVE":20.98,
    "SMILES":"C(NCC(C1)(C2)CC(C3)CC1CC23)(NC(CCc4ccccc4)=O)(C(F)(F)F)C(F)(F)F",
    "HIT":0.0,
    "question":"Does C(NCC(C1)(C2)CC(C3)CC1CC23)(NC(CCc4ccccc4)=O)(C(F)(F)F)C(F)(F)F demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":2347
  },
  {
    "COADD_ID":"CO-ADD:0222518",
    "INHIB_AVE":7.42,
    "SMILES":"[N+](=O)([O-])c(ccc(c1\\C=N\\c(ccc(c2Cl)OC)c2)O)c1",
    "HIT":0.0,
    "question":"Is [N+](=O)([O-])c(ccc(c1\\C=N\\c(ccc(c2Cl)OC)c2)O)c1 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":25400
  },
  {
    "COADD_ID":"CO-ADD:0244690",
    "INHIB_AVE":51.55,
    "SMILES":"C(F)(F)(C(C)OS(=O)(=O)c1ccc(cc1)N)[N+](=O)[O-]",
    "HIT":1.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C(F)(F)(C(C)OS(=O)(=O)c1ccc(cc1)N)[N+](=O)[O-]?",
    "answer":"Yes",
    "_id":224
  },
  {
    "COADD_ID":"CO-ADD:0226134",
    "INHIB_AVE":6.43,
    "SMILES":"S(=O)(=O)(N(c1ccc(cc1)CC)Cc2ccccc2C)c3cccn(c(nn4)CC)c34",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound S(=O)(=O)(N(c1ccc(cc1)CC)Cc2ccccc2C)c3cccn(c(nn4)CC)c34?",
    "answer":"No",
    "_id":29389
  },
  {
    "COADD_ID":"CO-ADD:0312440",
    "INHIB_AVE":1.04,
    "SMILES":"c1(SCC(=O)NCc2ccco2)n(C)c3c(cccc3)n1",
    "HIT":0.0,
    "question":"Can c1(SCC(=O)NCc2ccco2)n(C)c3c(cccc3)n1 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":53280
  },
  {
    "COADD_ID":"CO-ADD:0301691",
    "INHIB_AVE":8.46,
    "SMILES":"N1CC(C)CC(=O)C1(C)C.Cl",
    "HIT":0.0,
    "question":"Does N1CC(C)CC(=O)C1(C)C.Cl show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":21577
  },
  {
    "COADD_ID":"CO-ADD:0231125",
    "INHIB_AVE":5.1,
    "SMILES":"N1(CNc2cccc(Br)c2)C(=O)\\C(\\SC1=O)=C([H])\\c(ccc(c34)OCO3)c4",
    "HIT":0.0,
    "question":"Can N1(CNc2cccc(Br)c2)C(=O)\\C(\\SC1=O)=C([H])\\c(ccc(c34)OCO3)c4 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":35213
  },
  {
    "COADD_ID":"CO-ADD:0287344",
    "INHIB_AVE":-8.54,
    "SMILES":"N12C(N=C(N)c(c3c(CCCCC3)s4)c14)=C(C(c5ccc(c(OC)c5)OCc6ccccc6)C7=C2CCCC7=O)C#N",
    "HIT":0.0,
    "question":"Can exposure to N12C(N=C(N)c(c3c(CCCCC3)s4)c14)=C(C(c5ccc(c(OC)c5)OCc6ccccc6)C7=C2CCCC7=O)C#N lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":77338
  },
  {
    "COADD_ID":"CO-ADD:0232574",
    "INHIB_AVE":7.55,
    "SMILES":"[N+](=O)([O-])c1c(C)ccc(c1)C(=O)Nc(cccc2C(C)O)c2",
    "HIT":0.0,
    "question":"Can exposure to [N+](=O)([O-])c1c(C)ccc(c1)C(=O)Nc(cccc2C(C)O)c2 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":24880
  },
  {
    "COADD_ID":"CO-ADD:0331755",
    "INHIB_AVE":-3.5,
    "SMILES":"C1(=COc(c2C1=O)ccc(C)c2)C3C4=C(CC(c5cccs5)CC4=O)NC(C)=C3C(=O)OCC6CCCO6",
    "HIT":0.0,
    "question":"Can exposure to C1(=COc(c2C1=O)ccc(C)c2)C3C4=C(CC(c5cccs5)CC4=O)NC(C)=C3C(=O)OCC6CCCO6 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":68537
  },
  {
    "COADD_ID":"CO-ADD:0257481",
    "INHIB_AVE":-2.74,
    "SMILES":"C1(C(=O)OCC(Cl)(Cl)Cl)=C(C)NC(NC1c2ccc(c(Cl)c2)Cl)=O",
    "HIT":0.0,
    "question":"Does C1(C(=O)OCC(Cl)(Cl)Cl)=C(C)NC(NC1c2ccc(c(Cl)c2)Cl)=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":66474
  },
  {
    "COADD_ID":"CO-ADD:0293640",
    "INHIB_AVE":1.85,
    "SMILES":"c1(C(F)(F)F)c(F)c(F)c(c(F)c1F)NCCCCCNC(C)=O",
    "HIT":0.0,
    "question":"Does treatment with c1(C(F)(F)F)c(F)c(F)c(c(F)c1F)NCCCCCNC(C)=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":49762
  },
  {
    "COADD_ID":"CO-ADD:0233246",
    "INHIB_AVE":-3.64,
    "SMILES":"[N+](=O)([O-])c(cccc1C(=O)N\\N=C(\/C)\\CC(NCC=C)=O)c1",
    "HIT":0.0,
    "question":"Is [N+](=O)([O-])c(cccc1C(=O)N\\N=C(\/C)\\CC(NCC=C)=O)c1 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":68881
  },
  {
    "COADD_ID":"CO-ADD:0240992",
    "INHIB_AVE":16.25,
    "SMILES":"C(C#N)(C1c2ccc(cc2)Br)=C(N)N(C(CC(C)(C)CC3=O)=C13)c4ccc(cc4)C",
    "HIT":0.0,
    "question":"Does C(C#N)(C1c2ccc(cc2)Br)=C(N)N(C(CC(C)(C)CC3=O)=C13)c4ccc(cc4)C demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":6048
  },
  {
    "COADD_ID":"CO-ADD:0135759",
    "INHIB_AVE":-12.29,
    "SMILES":"n1c(cccc2)c2c(cc(C)n3)n3c1",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound n1c(cccc2)c2c(cc(C)n3)n3c1?",
    "answer":"No",
    "_id":80206
  },
  {
    "COADD_ID":"CO-ADD:0305832",
    "INHIB_AVE":9.28,
    "SMILES":"c1(NC(=O)c2ccc(c(OC)c2)OCc3ccccc3Cl)sc(c4c1C(N)=O)CCCC4",
    "HIT":0.0,
    "question":"Does treatment with c1(NC(=O)c2ccc(c(OC)c2)OCc3ccccc3Cl)sc(c4c1C(N)=O)CCCC4 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":19101
  },
  {
    "COADD_ID":"CO-ADD:0233299",
    "INHIB_AVE":1.67,
    "SMILES":"N1(CCCCCC(=O)Nc(cc2)c(C)cc2[N+](=O)[O-])C(=O)c(c3C1=O)cccc3",
    "HIT":0.0,
    "question":"Does treatment with N1(CCCCCC(=O)Nc(cc2)c(C)cc2[N+](=O)[O-])C(=O)c(c3C1=O)cccc3 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":50551
  },
  {
    "COADD_ID":"CO-ADD:0301935",
    "INHIB_AVE":9.29,
    "SMILES":"S(=O)(=O)(c1ccc(cc1)C)N(c2ccc(cc2)OC)c3ccccn3",
    "HIT":0.0,
    "question":"Can S(=O)(=O)(c1ccc(cc1)C)N(c2ccc(cc2)OC)c3ccccn3 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":19072
  },
  {
    "COADD_ID":"CO-ADD:0293786",
    "INHIB_AVE":-10.13,
    "SMILES":"N1(CC(OC)=O)C(=O)c2c(C(C)=N1)cccc2",
    "HIT":0.0,
    "question":"Can N1(CC(OC)=O)C(=O)c2c(C(C)=N1)cccc2 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":78806
  },
  {
    "COADD_ID":"CO-ADD:0244012",
    "INHIB_AVE":8.57,
    "SMILES":"C1C[C@](C)(C([C@H](O)CC(\\C(=C(\\C(=O)OCc2ccccc2)\/CC\\C=C(\/C)\\C)\\[C@@H](OC(C)=O)C3)[C@]34C)[C@]4(C)CC5)C5[C@H](C)[C@@H]1OC(=O)CCCCCO[N+]([O-])=O",
    "HIT":0.0,
    "question":"Is C1C[C@](C)(C([C@H](O)CC(\\C(=C(\\C(=O)OCc2ccccc2)\/CC\\C=C(\/C)\\C)\\[C@@H](OC(C)=O)C3)[C@]34C)[C@]4(C)CC5)C5[C@H](C)[C@@H]1OC(=O)CCCCCO[N+]([O-])=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":21242
  },
  {
    "COADD_ID":"CO-ADD:0242568",
    "INHIB_AVE":16.38,
    "SMILES":"C1(C(=O)NNC(=O)c2ccc(cc2)Br)=Cc(cccc3CC=C)c3OC1=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C1(C(=O)NNC(=O)c2ccc(cc2)Br)=Cc(cccc3CC=C)c3OC1=O?",
    "answer":"No",
    "_id":5923
  },
  {
    "COADD_ID":"CO-ADD:0311999",
    "INHIB_AVE":6.76,
    "SMILES":"C(C(OCC)=O)(C(F)(F)F)(NC(=O)c1ccco1)Nc2sc(c3c2C#N)CC(CC3)C",
    "HIT":0.0,
    "question":"Is C(C(OCC)=O)(C(F)(F)F)(NC(=O)c1ccco1)Nc2sc(c3c2C#N)CC(CC3)C capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":27988
  },
  {
    "COADD_ID":"CO-ADD:0326241",
    "INHIB_AVE":-3.53,
    "SMILES":"C(=O)(N1CCCC1)CC(c2ccccc2OC)c(ccc(c34)OCO3)c4",
    "HIT":0.0,
    "question":"Does C(=O)(N1CCCC1)CC(c2ccccc2OC)c(ccc(c34)OCO3)c4 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":68621
  },
  {
    "COADD_ID":"CO-ADD:0319756",
    "INHIB_AVE":-3.21,
    "SMILES":"S(=O)(=O)(Nc(cc1)ccc1OC(F)(F)Cl)c2c(Cl)cc(c(O3)c2)NC3=O",
    "HIT":0.0,
    "question":"Can S(=O)(=O)(Nc(cc1)ccc1OC(F)(F)Cl)c2c(Cl)cc(c(O3)c2)NC3=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":67777
  },
  {
    "COADD_ID":"CO-ADD:0219658",
    "INHIB_AVE":6.36,
    "SMILES":"C(=O)(N\\N=C\\c(ccc(c1OC)OCc(cc2)ccc2Br)c1)C(=O)Nc3ccc(cc3C)Cl",
    "HIT":0.0,
    "question":"Does C(=O)(N\\N=C\\c(ccc(c1OC)OCc(cc2)ccc2Br)c1)C(=O)Nc3ccc(cc3C)Cl show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":29725
  },
  {
    "COADD_ID":"CO-ADD:0230254",
    "INHIB_AVE":-0.02,
    "SMILES":"C(OC)(=O)c1ccc(cc1)OCc(cc2)ccc2Cl",
    "HIT":0.0,
    "question":"Is C(OC)(=O)c1ccc(cc1)OCc(cc2)ccc2Cl effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":57577
  },
  {
    "COADD_ID":"CO-ADD:0320828",
    "INHIB_AVE":12.55,
    "SMILES":"[N+](=O)([O-])c1cccc(c1)n2cccc2",
    "HIT":0.0,
    "question":"Can exposure to [N+](=O)([O-])c1cccc(c1)n2cccc2 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":11391
  },
  {
    "COADD_ID":"CO-ADD:0245794",
    "INHIB_AVE":8.89,
    "SMILES":"N1(c2ccc(cc2)OCC)C(=O)C3C(C(C=C4)C5C(=C(c6ccccc6)CC(C5C7=O)C(N7c8ccc(cc8)OCC)=O)C34)C1=O",
    "HIT":0.0,
    "question":"Does N1(c2ccc(cc2)OCC)C(=O)C3C(C(C=C4)C5C(=C(c6ccccc6)CC(C5C7=O)C(N7c8ccc(cc8)OCC)=O)C34)C1=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":20250
  },
  {
    "COADD_ID":"CO-ADD:0234105",
    "INHIB_AVE":21.56,
    "SMILES":"N1(c2ccc(cc2)OC)CC(CC1=O)C(=O)N\\N=C\\c3ccccc3",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound N1(c2ccc(cc2)OC)CC(CC1=O)C(=O)N\\N=C\\c3ccccc3?",
    "answer":"No",
    "_id":2105
  },
  {
    "COADD_ID":"CO-ADD:0252297",
    "INHIB_AVE":18.49,
    "SMILES":"c1(ccc(cc1Cl)Cl)C(=O)Nc2ccc(cc2C#N)Cl",
    "HIT":0.0,
    "question":"Does c1(ccc(cc1Cl)Cl)C(=O)Nc2ccc(cc2C#N)Cl demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":3910
  },
  {
    "COADD_ID":"CO-ADD:0279137",
    "INHIB_AVE":-4.51,
    "SMILES":"C(=C\\c(cc1I)cc(c1OCc2ccccc2)I)(\/C3=O)\\C(=O)NC(=O)N3",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C(=C\\c(cc1I)cc(c1OCc2ccccc2)I)(\/C3=O)\\C(=O)NC(=O)N3?",
    "answer":"No",
    "_id":70863
  },
  {
    "COADD_ID":"CO-ADD:0294903",
    "INHIB_AVE":5.52,
    "SMILES":"[N+](=O)([O-])c1c(C)ccc(C(=O)COC(=O)c2cccc(C)c2O)c1",
    "HIT":0.0,
    "question":"Does the proposed molecule [N+](=O)([O-])c1c(C)ccc(C(=O)COC(=O)c2cccc(C)c2O)c1 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":33349
  },
  {
    "COADD_ID":"CO-ADD:0242963",
    "INHIB_AVE":-0.96,
    "SMILES":"[N+](O)(=O)[O-].n(cn(n1)CCCCC(Cl)(Cl)Cl)c1",
    "HIT":0.0,
    "question":"Can exposure to [N+](O)(=O)[O-].n(cn(n1)CCCCC(Cl)(Cl)Cl)c1 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":60970
  },
  {
    "COADD_ID":"CO-ADD:0249376",
    "INHIB_AVE":0.99,
    "SMILES":"C(=O)(N(CC1)CCN1c2ccc(cc2)F)c3ccccc3Br",
    "HIT":0.0,
    "question":"Can C(=O)(N(CC1)CCN1c2ccc(cc2)F)c3ccccc3Br act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":53481
  },
  {
    "COADD_ID":"CO-ADD:0300029",
    "INHIB_AVE":-4.27,
    "SMILES":"C1(c2ccc(cc2)OC)=Cc3c(OC1=O)ccc(cccc4)c34",
    "HIT":0.0,
    "question":"Does the proposed molecule C1(c2ccc(cc2)OC)=Cc3c(OC1=O)ccc(cccc4)c34 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":70347
  },
  {
    "COADD_ID":"CO-ADD:0215170",
    "INHIB_AVE":9.72,
    "SMILES":"C(=O)(Nc(cc1)ccc1I)Oc2ccc(cc2OC)CC=C",
    "HIT":0.0,
    "question":"Is C(=O)(Nc(cc1)ccc1I)Oc2ccc(cc2OC)CC=C capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":17799
  },
  {
    "COADD_ID":"CO-ADD:0323740",
    "INHIB_AVE":6.54,
    "SMILES":"S(=O)(=O)(c1ccc(cc1)C)N2Cc3c(CC2C(=O)NCc(cc4)ccc4Br)cccc3",
    "HIT":0.0,
    "question":"Is S(=O)(=O)(c1ccc(cc1)C)N2Cc3c(CC2C(=O)NCc(cc4)ccc4Br)cccc3 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":28959
  },
  {
    "COADD_ID":"CO-ADD:0248953",
    "INHIB_AVE":-14.13,
    "SMILES":"C(COc(cc1)ccc1Br)(=O)Nc2cccc(F)c2",
    "HIT":0.0,
    "question":"Does C(COc(cc1)ccc1Br)(=O)Nc2cccc(F)c2 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":81011
  },
  {
    "COADD_ID":"CO-ADD:0218643",
    "INHIB_AVE":3.79,
    "SMILES":"[N+](=O)([O-])c(cc(cc1[N+](=O)[O-])C(=O)NC(CSCc2ccccc2)C(=O)N\\N=C\\c(cccc3[N+](=O)[O-])c3)c1",
    "HIT":0.0,
    "question":"Is [N+](=O)([O-])c(cc(cc1[N+](=O)[O-])C(=O)NC(CSCc2ccccc2)C(=O)N\\N=C\\c(cccc3[N+](=O)[O-])c3)c1 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":41124
  },
  {
    "COADD_ID":"CO-ADD:0155759",
    "INHIB_AVE":-13.25,
    "SMILES":"O=C1N(C2=CC=CC(C(OC)=O)=C2)C(C3C4C(C=CC=C5)=C5C(C6=C4C=CC=C6)C13)=O",
    "HIT":0.0,
    "question":"Is O=C1N(C2=CC=CC(C(OC)=O)=C2)C(C3C4C(C=CC=C5)=C5C(C6=C4C=CC=C6)C13)=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":80642
  },
  {
    "COADD_ID":"CO-ADD:0223663",
    "INHIB_AVE":3.55,
    "SMILES":"s1c(\\C=N\\NC(=O)c2ccc(cc2)OCC=C)ccc1Br",
    "HIT":0.0,
    "question":"Is s1c(\\C=N\\NC(=O)c2ccc(cc2)OCC=C)ccc1Br effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":42169
  },
  {
    "COADD_ID":"CO-ADD:0255141",
    "INHIB_AVE":-1.37,
    "SMILES":"S(c1ccccc1)(=O)(=O)N(c2ccc(cc2)OC)CC(=O)NC3CC(CC34)CC4",
    "HIT":0.0,
    "question":"Does treatment with S(c1ccccc1)(=O)(=O)N(c2ccc(cc2)OC)CC(=O)NC3CC(CC34)CC4 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":62310
  },
  {
    "COADD_ID":"CO-ADD:0328183",
    "INHIB_AVE":2.11,
    "SMILES":"S(c1ccccc1)(=O)(=O)c2c(O)c(C)cc(NC(c3ccccc3)=O)c2C(C)C",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound S(c1ccccc1)(=O)(=O)c2c(O)c(C)cc(NC(c3ccccc3)=O)c2C(C)C?",
    "answer":"No",
    "_id":48598
  },
  {
    "COADD_ID":"CO-ADD:0137234",
    "INHIB_AVE":19.89,
    "SMILES":"O=C(CC(C(N([H])C(c1ccccc1)C(OC(C)C(NC(=O)c2c(O)cccn2)C(=O)N([H])C(CC)C(=O)N3C(CCC3)C(=O)N(C)C(Cc4ccccc4)C5=O)=O)=O)N56)CC6",
    "HIT":0.0,
    "question":"Can O=C(CC(C(N([H])C(c1ccccc1)C(OC(C)C(NC(=O)c2c(O)cccn2)C(=O)N([H])C(CC)C(=O)N3C(CCC3)C(=O)N(C)C(Cc4ccccc4)C5=O)=O)=O)N56)CC6 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":2941
  },
  {
    "COADD_ID":"CO-ADD:0307533",
    "INHIB_AVE":6.84,
    "SMILES":"N1(CCC(O)=O)C(=O)c2c(cc(cc2)F)C1=O",
    "HIT":0.0,
    "question":"Does N1(CCC(O)=O)C(=O)c2c(cc(cc2)F)C1=O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":27634
  },
  {
    "COADD_ID":"CO-ADD:0291788",
    "INHIB_AVE":-0.26,
    "SMILES":"N1(c2ccc(cc2)F)C(=O)\\C(=C\\c(cc(n3c4ccc(cc4)Br)C)c3C)\\C(NC1=S)=O",
    "HIT":0.0,
    "question":"Can N1(c2ccc(cc2)F)C(=O)\\C(=C\\c(cc(n3c4ccc(cc4)Br)C)c3C)\\C(NC1=S)=O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":58461
  },
  {
    "COADD_ID":"CO-ADD:0284544",
    "INHIB_AVE":5.7,
    "SMILES":"N1(N=C(CC1(O)c(cccn2)c2)C)C(=O)c(cccn3)c3",
    "HIT":0.0,
    "question":"Does the proposed molecule N1(N=C(CC1(O)c(cccn2)c2)C)C(=O)c(cccn3)c3 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":32531
  },
  {
    "COADD_ID":"CO-ADD:0277581",
    "INHIB_AVE":-13.95,
    "SMILES":"N1(c2ccccc2)C(=O)CC(N(CC3)CCN3C(C)=O)C1=O",
    "HIT":0.0,
    "question":"Does N1(c2ccccc2)C(=O)CC(N(CC3)CCN3C(C)=O)C1=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":80947
  },
  {
    "COADD_ID":"CO-ADD:0223808",
    "INHIB_AVE":7.83,
    "SMILES":"[N+](=O)([O-])c1ccccc1\\C=C\\C(=O)Nc2ccccc2OC",
    "HIT":0.0,
    "question":"Is [N+](=O)([O-])c1ccccc1\\C=C\\C(=O)Nc2ccccc2OC effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":23825
  },
  {
    "COADD_ID":"CO-ADD:0158422",
    "INHIB_AVE":2.85,
    "SMILES":"O=C(C(C=C1)=CC=C1NC(CCCC)=O)NC2=CC=C(OC)C=C2",
    "HIT":0.0,
    "question":"Does O=C(C(C=C1)=CC=C1NC(CCCC)=O)NC2=CC=C(OC)C=C2 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":45350
  },
  {
    "COADD_ID":"CO-ADD:0299179",
    "INHIB_AVE":3.42,
    "SMILES":"N1(Cc(cc2)ccc2Cl)C(=O)CC(N(CC3)CCC3C(N)=O)C1=O",
    "HIT":0.0,
    "question":"Is N1(Cc(cc2)ccc2Cl)C(=O)CC(N(CC3)CCC3C(N)=O)C1=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":42732
  },
  {
    "COADD_ID":"CO-ADD:0277929",
    "INHIB_AVE":1.95,
    "SMILES":"C(=S)(Nc1ccccc1)Nc(cc2)ccc2NC(=S)Nc3ccccc3",
    "HIT":0.0,
    "question":"Does C(=S)(Nc1ccccc1)Nc(cc2)ccc2NC(=S)Nc3ccccc3 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":49336
  },
  {
    "COADD_ID":"CO-ADD:0243761",
    "INHIB_AVE":5.16,
    "SMILES":"c(c1cc(OCO2)c2c(OC)c1)(c(N)[nH]n3)c3c4ccc(OC)cc4",
    "HIT":0.0,
    "question":"Does c(c1cc(OCO2)c2c(OC)c1)(c(N)[nH]n3)c3c4ccc(OC)cc4 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":34908
  },
  {
    "COADD_ID":"CO-ADD:0158473",
    "INHIB_AVE":3.61,
    "SMILES":"O=S(NC1=CC=CC=N1)(C2=CC(C(C(C=C3)=CC=C3Br)=O)=CC=C2C)=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound O=S(NC1=CC=CC=N1)(C2=CC(C(C(C=C3)=CC=C3Br)=O)=CC=C2C)=O?",
    "answer":"No",
    "_id":41881
  },
  {
    "COADD_ID":"CO-ADD:0256741",
    "INHIB_AVE":-2.28,
    "SMILES":"n1c(c2ccccc2)c([nH]c1c(ccc3c4c(OC)ccc(c4)[N+](=O)[O-])o3)c5ccccc5",
    "HIT":0.0,
    "question":"Can n1c(c2ccccc2)c([nH]c1c(ccc3c4c(OC)ccc(c4)[N+](=O)[O-])o3)c5ccccc5 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":65194
  },
  {
    "COADD_ID":"CO-ADD:0228202",
    "INHIB_AVE":2.75,
    "SMILES":"S(=O)(=O)(N1CCCCC1)c2c(Br)ccc(c2)C(=O)Nc3sc(c4c3C#N)CCC4",
    "HIT":0.0,
    "question":"Does treatment with S(=O)(=O)(N1CCCCC1)c2c(Br)ccc(c2)C(=O)Nc3sc(c4c3C#N)CCC4 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":45752
  },
  {
    "COADD_ID":"CO-ADD:0319217",
    "INHIB_AVE":3.16,
    "SMILES":"c1(c2)c(cc(OC)c2NC(=O)c(cc3)ccc3C4CCCCC4)c5c(cccc5)o1",
    "HIT":0.0,
    "question":"Can exposure to c1(c2)c(cc(OC)c2NC(=O)c(cc3)ccc3C4CCCCC4)c5c(cccc5)o1 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":43883
  },
  {
    "COADD_ID":"CO-ADD:0157982",
    "INHIB_AVE":-13.28,
    "SMILES":"O=S(OC1=C(Br)C(C)=C(C(S2)=C1Br)OC2=O)(C3=CC=CC=C3)=O",
    "HIT":0.0,
    "question":"Does treatment with O=S(OC1=C(Br)C(C)=C(C(S2)=C1Br)OC2=O)(C3=CC=CC=C3)=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":80661
  },
  {
    "COADD_ID":"CO-ADD:0329399",
    "INHIB_AVE":-3.54,
    "SMILES":"c1(SCCOc(cc2)ccc2C(C)(C)C)nc(c(C)n1c3ccccc3)C",
    "HIT":0.0,
    "question":"Can c1(SCCOc(cc2)ccc2C(C)(C)C)nc(c(C)n1c3ccccc3)C effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":68632
  },
  {
    "COADD_ID":"CO-ADD:0223328",
    "INHIB_AVE":87.03,
    "SMILES":"S(=O)(=O)(c1ccc(cc1)\\N=C\\c(cc2)ccc2OC)Nc3cc(OC)ncn3",
    "HIT":1.0,
    "question":"Does S(=O)(=O)(c1ccc(cc1)\\N=C\\c(cc2)ccc2OC)Nc3cc(OC)ncn3 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"Yes",
    "_id":140
  },
  {
    "COADD_ID":"CO-ADD:0223575",
    "INHIB_AVE":-7.95,
    "SMILES":"S(=O)(=O)(Nc1ccccc1OC)c2c(C)ccc(c2)C(=O)Nc3ccccc3OC",
    "HIT":0.0,
    "question":"Can S(=O)(=O)(Nc1ccccc1OC)c2c(C)ccc(c2)C(=O)Nc3ccccc3OC effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":76654
  },
  {
    "COADD_ID":"CO-ADD:0214998",
    "INHIB_AVE":0.28,
    "SMILES":"[N+](=O)([O-])c(cc1)ccc1c2ccc(cc2)NC(=O)Nc(cc3)ccc3Cl",
    "HIT":0.0,
    "question":"Does [N+](=O)([O-])c(cc1)ccc1c2ccc(cc2)NC(=O)Nc(cc3)ccc3Cl demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":56310
  },
  {
    "COADD_ID":"CO-ADD:0294416",
    "INHIB_AVE":9.58,
    "SMILES":"c1(nc(c2ccc(cc2)Cl)cc3C(F)(F)F)n3nc(C(=O)Nc4sc(c5c4C(OCC)=O)CCCC5)c1Cl",
    "HIT":0.0,
    "question":"Is c1(nc(c2ccc(cc2)Cl)cc3C(F)(F)F)n3nc(C(=O)Nc4sc(c5c4C(OCC)=O)CCCC5)c1Cl effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":18202
  },
  {
    "COADD_ID":"CO-ADD:0134098",
    "INHIB_AVE":9.89,
    "SMILES":"O=C(c1[nH]c([N+](=O)[O-])cn1)NCc2cccc(OC(F)(F)F)c2",
    "HIT":0.0,
    "question":"Does O=C(c1[nH]c([N+](=O)[O-])cn1)NCc2cccc(OC(F)(F)F)c2 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":17312
  },
  {
    "COADD_ID":"CO-ADD:0243149",
    "INHIB_AVE":8.59,
    "SMILES":"c(CC(C1)ON=C1C(NN)=O)(c(Br)c2OC)c(Br)c(c23)OCO3",
    "HIT":0.0,
    "question":"Does treatment with c(CC(C1)ON=C1C(NN)=O)(c(Br)c2OC)c(Br)c(c23)OCO3 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":21200
  },
  {
    "COADD_ID":"CO-ADD:0326512",
    "INHIB_AVE":17.15,
    "SMILES":"N1(c2c(cccc2F)F)C(CCCC3=O)=C3C(C(C#N)=C1N)c4cccc(OC)c4",
    "HIT":0.0,
    "question":"Does the proposed molecule N1(c2c(cccc2F)F)C(CCCC3=O)=C3C(C(C#N)=C1N)c4cccc(OC)c4 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":5124
  },
  {
    "COADD_ID":"CO-ADD:0257479",
    "INHIB_AVE":7.71,
    "SMILES":"C(=S)(c(ccc(c1OCc2ccccc2)OC)c1)N(CC3)CCO3",
    "HIT":0.0,
    "question":"Is C(=S)(c(ccc(c1OCc2ccccc2)OC)c1)N(CC3)CCO3 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":24280
  },
  {
    "COADD_ID":"CO-ADD:0288006",
    "INHIB_AVE":-10.33,
    "SMILES":"[N+](=O)([O-])c1ccc(cc1)N\\N=C(\/C)\\c2ccco2",
    "HIT":0.0,
    "question":"Does [N+](=O)([O-])c1ccc(cc1)N\\N=C(\/C)\\c2ccco2 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":78935
  },
  {
    "COADD_ID":"CO-ADD:0225921",
    "INHIB_AVE":6.33,
    "SMILES":"N12C(C=CC(c3ccc(c(C)c3)C)=N1)=NN(CC(=O)Nc(cc4)ccc4C#N)C2=O",
    "HIT":0.0,
    "question":"Does treatment with N12C(C=CC(c3ccc(c(C)c3)C)=N1)=NN(CC(=O)Nc(cc4)ccc4C#N)C2=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":29886
  },
  {
    "COADD_ID":"CO-ADD:0242761",
    "INHIB_AVE":-5.42,
    "SMILES":"c1(sc2c(ccc(C)c2)n1)NC(=O)c3cccc(Br)c3",
    "HIT":0.0,
    "question":"Is c1(sc2c(ccc(C)c2)n1)NC(=O)c3cccc(Br)c3 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":72685
  },
  {
    "COADD_ID":"CO-ADD:0222202",
    "INHIB_AVE":5.11,
    "SMILES":"c1(c2ccc(c3c2)cccc3)oc4c(ccc(c4)\\N=C\\c(cc5)ccc5Cl)n1",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(c2ccc(c3c2)cccc3)oc4c(ccc(c4)\\N=C\\c(cc5)ccc5Cl)n1?",
    "answer":"No",
    "_id":35140
  },
  {
    "COADD_ID":"CO-ADD:0293592",
    "INHIB_AVE":9.52,
    "SMILES":"n1(c2ccccc2)c(COc(ccc(c3C)C)c3)nnc1SCC(=O)Nc(cc4)ccc4NC(C)=O",
    "HIT":0.0,
    "question":"Does treatment with n1(c2ccccc2)c(COc(ccc(c3C)C)c3)nnc1SCC(=O)Nc(cc4)ccc4NC(C)=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":18352
  },
  {
    "COADD_ID":"CO-ADD:0157645",
    "INHIB_AVE":8.81,
    "SMILES":"N#CC(C(C1=CC(Br)=CC=C1)C([N+]([O-])=O)=C(C2=CC=CC=C2C(OC)=O)O3)=C3N",
    "HIT":0.0,
    "question":"Can exposure to N#CC(C(C1=CC(Br)=CC=C1)C([N+]([O-])=O)=C(C2=CC=CC=C2C(OC)=O)O3)=C3N lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":20511
  },
  {
    "COADD_ID":"CO-ADD:0227219",
    "INHIB_AVE":11.56,
    "SMILES":"[N+](=O)([O-])c(c1)cc(c(O)c1\\C=N\/NC(CNC(=O)c2ccccc2Br)=O)Br",
    "HIT":0.0,
    "question":"Does treatment with [N+](=O)([O-])c(c1)cc(c(O)c1\\C=N\/NC(CNC(=O)c2ccccc2Br)=O)Br result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":13329
  },
  {
    "COADD_ID":"CO-ADD:0299198",
    "INHIB_AVE":-3.05,
    "SMILES":"N1(c2ccc(cc2)OCC)C(=O)C(CC1=O)NCc3ccc(cc3Cl)Cl",
    "HIT":0.0,
    "question":"Can N1(c2ccc(cc2)OCC)C(=O)C(CC1=O)NCc3ccc(cc3Cl)Cl effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":67352
  },
  {
    "COADD_ID":"CO-ADD:0222728",
    "INHIB_AVE":7.48,
    "SMILES":"N1(c(cc2)ccc2C(C)=O)C(=O)C(C3C1=O)CCCC3",
    "HIT":0.0,
    "question":"Can exposure to N1(c(cc2)ccc2C(C)=O)C(=O)C(C3C1=O)CCCC3 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":25162
  },
  {
    "COADD_ID":"CO-ADD:0324759",
    "INHIB_AVE":12.37,
    "SMILES":"C(C(c1ccccc1)=O)(C2c3cccc(F)c3)=C(O)C(N2c4ccc(cc4)OCC(O)=O)=O",
    "HIT":0.0,
    "question":"Can C(C(c1ccccc1)=O)(C2c3cccc(F)c3)=C(O)C(N2c4ccc(cc4)OCC(O)=O)=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":11729
  },
  {
    "COADD_ID":"CO-ADD:0155849",
    "INHIB_AVE":10.99,
    "SMILES":"[O-][N+](C1=CC(\/C(C(N2)=O)=N\\NC(CNC3=CC=C4C=CC=CC4=C3)=O)=C2C=C1)=O",
    "HIT":0.0,
    "question":"Is [O-][N+](C1=CC(\/C(C(N2)=O)=N\\NC(CNC3=CC=C4C=CC=CC4=C3)=O)=C2C=C1)=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":14551
  },
  {
    "COADD_ID":"CO-ADD:0311616",
    "INHIB_AVE":-6.68,
    "SMILES":"N1(Cc2ccccc2)\\C(=N\\c(cc3)ccc3OC(F)(Cl)F)\\SC(C(=O)Nc(cc4)ccc4Cl)CC1=O",
    "HIT":0.0,
    "question":"Does treatment with N1(Cc2ccccc2)\\C(=N\\c(cc3)ccc3OC(F)(Cl)F)\\SC(C(=O)Nc(cc4)ccc4Cl)CC1=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":74851
  },
  {
    "COADD_ID":"CO-ADD:0156172",
    "INHIB_AVE":-7.56,
    "SMILES":"IC1=CC=C(C=C1)\/C=N\/C2=CC=CC(C(O3)=NC4=C3C=CC(C)=C4)=C2",
    "HIT":0.0,
    "question":"Does the proposed molecule IC1=CC=C(C=C1)\/C=N\/C2=CC=CC(C(O3)=NC4=C3C=CC(C)=C4)=C2 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":76148
  },
  {
    "COADD_ID":"CO-ADD:0218698",
    "INHIB_AVE":21.77,
    "SMILES":"C(CSc(cc1)ccc1Cl)(=O)N\\N=C\\c2ccccc2O",
    "HIT":0.0,
    "question":"Is C(CSc(cc1)ccc1Cl)(=O)N\\N=C\\c2ccccc2O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":2009
  },
  {
    "COADD_ID":"CO-ADD:0327989",
    "INHIB_AVE":11.92,
    "SMILES":"C1(C2c(cccn3)c3)=C(CC(c4ccc(cc4)F)CC1=O)Nc(c5N2C(C)=O)cccc5",
    "HIT":0.0,
    "question":"Does C1(C2c(cccn3)c3)=C(CC(c4ccc(cc4)F)CC1=O)Nc(c5N2C(C)=O)cccc5 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":12592
  },
  {
    "COADD_ID":"CO-ADD:0287365",
    "INHIB_AVE":-4.38,
    "SMILES":"C(=C\/c1cccc(c1)OCc2ccccc2F)(\/C(=O)NC(N3)=O)\\C3=O",
    "HIT":0.0,
    "question":"Does C(=C\/c1cccc(c1)OCc2ccccc2F)(\/C(=O)NC(N3)=O)\\C3=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":70583
  },
  {
    "COADD_ID":"CO-ADD:0229886",
    "INHIB_AVE":11.67,
    "SMILES":"N1(NC(=C(\\C=N\\CCO)C1=O)C)c(c(F)c2F)c(F)c(c2C(F)(F)F)F",
    "HIT":0.0,
    "question":"Can N1(NC(=C(\\C=N\\CCO)C1=O)C)c(c(F)c2F)c(F)c(c2C(F)(F)F)F act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":13111
  },
  {
    "COADD_ID":"CO-ADD:0160094",
    "INHIB_AVE":4.19,
    "SMILES":"O=C(C(C1=CC=CC=C1)C2=CC=CC=C2)NCC(N\/N=C(CC)\/C3=CC=CC=C3)=O",
    "HIT":0.0,
    "question":"Can O=C(C(C1=CC=CC=C1)C2=CC=CC=C2)NCC(N\/N=C(CC)\/C3=CC=CC=C3)=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":39282
  },
  {
    "COADD_ID":"CO-ADD:0234572",
    "INHIB_AVE":1.62,
    "SMILES":"c1(c(Br)cc(cc1\\C=N\\NC(COc(ccc(c2C)C)c2)=O)Br)OC(=O)c(cc3OC)cc(c3OC)OC",
    "HIT":0.0,
    "question":"Is c1(c(Br)cc(cc1\\C=N\\NC(COc(ccc(c2C)C)c2)=O)Br)OC(=O)c(cc3OC)cc(c3OC)OC effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":50809
  },
  {
    "COADD_ID":"CO-ADD:0254379",
    "INHIB_AVE":10.36,
    "SMILES":"S(=O)(=O)(NC(Cc1ccccc1)C(O)=O)c2ccccc2[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Does S(=O)(=O)(NC(Cc1ccccc1)C(O)=O)c2ccccc2[N+](=O)[O-] show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":16094
  },
  {
    "COADD_ID":"CO-ADD:0277813",
    "INHIB_AVE":4.61,
    "SMILES":"N1(C2c3ccc(c(OC)c3)OC)C(S\\C(=C\\c(cc4OCC)cc(c4O)I)\\C1=O)=NC(C)=C2C(OCC)=O",
    "HIT":0.0,
    "question":"Does N1(C2c3ccc(c(OC)c3)OC)C(S\\C(=C\\c(cc4OCC)cc(c4O)I)\\C1=O)=NC(C)=C2C(OCC)=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":37415
  },
  {
    "COADD_ID":"CO-ADD:0217083",
    "INHIB_AVE":6.23,
    "SMILES":"C(=O)(N\\N=C\\c1ccccc1OC)C(NCCC)=O",
    "HIT":0.0,
    "question":"Can C(=O)(N\\N=C\\c1ccccc1OC)C(NCCC)=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":30310
  },
  {
    "COADD_ID":"CO-ADD:0257170",
    "INHIB_AVE":1.3,
    "SMILES":"C(=O)(c1ccc(cc1)Cl)N(C)C(C)Cc(ccc(c23)OCO2)c3",
    "HIT":0.0,
    "question":"Is C(=O)(c1ccc(cc1)Cl)N(C)C(C)Cc(ccc(c23)OCO2)c3 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":52143
  },
  {
    "COADD_ID":"CO-ADD:0329242",
    "INHIB_AVE":17.26,
    "SMILES":"n1c(c2ccc(cc2)OC)nnn1CC(=O)Nc(cc3)ccc3F",
    "HIT":0.0,
    "question":"Is n1c(c2ccc(cc2)OC)nnn1CC(=O)Nc(cc3)ccc3F effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":5036
  },
  {
    "COADD_ID":"CO-ADD:0229322",
    "INHIB_AVE":3.02,
    "SMILES":"S1(=O)(=O)c(cccc2)c2C(Nc3ccccc3C(OC)=O)=N1",
    "HIT":0.0,
    "question":"Can S1(=O)(=O)c(cccc2)c2C(Nc3ccccc3C(OC)=O)=N1 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":44543
  },
  {
    "COADD_ID":"CO-ADD:0241897",
    "INHIB_AVE":3.96,
    "SMILES":"C(=C\\c(cc(cc1[N+](=O)[O-])[N+](=O)[O-])c1O)(\/C2=O)\\C(=O)N(C(=O)N2C)C",
    "HIT":0.0,
    "question":"Does C(=C\\c(cc(cc1[N+](=O)[O-])[N+](=O)[O-])c1O)(\/C2=O)\\C(=O)N(C(=O)N2C)C show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":40367
  },
  {
    "COADD_ID":"CO-ADD:0288840",
    "INHIB_AVE":-2.93,
    "SMILES":"C(N(C(=O)OC(C)(C)C)CCC1)C1C(=O)NCC#C",
    "HIT":0.0,
    "question":"Does the proposed molecule C(N(C(=O)OC(C)(C)C)CCC1)C1C(=O)NCC#C exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":67071
  },
  {
    "COADD_ID":"CO-ADD:0233208",
    "INHIB_AVE":1.55,
    "SMILES":"c1(c(cc2)ccn2)cc(c3ccc(cc3)Br)nc(ccc(cccc4)c45)c15",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(c(cc2)ccn2)cc(c3ccc(cc3)Br)nc(ccc(cccc4)c45)c15?",
    "answer":"No",
    "_id":51049
  },
  {
    "COADD_ID":"CO-ADD:0137878",
    "INHIB_AVE":4.96,
    "SMILES":"N#CC1=C(OC)C(OCO2)=C2C(OC)=C1",
    "HIT":0.0,
    "question":"Is N#CC1=C(OC)C(OCO2)=C2C(OC)=C1 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":35839
  },
  {
    "COADD_ID":"CO-ADD:0291559",
    "INHIB_AVE":-10.2,
    "SMILES":"N1(C(C)=O)C(c2cccc(Oc3ccccc3)c2)C(C(OC)=O)=C(NC1=O)C",
    "HIT":0.0,
    "question":"Does the proposed molecule N1(C(C)=O)C(c2cccc(Oc3ccccc3)c2)C(C(OC)=O)=C(NC1=O)C exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":78840
  },
  {
    "COADD_ID":"CO-ADD:0326812",
    "INHIB_AVE":-1.16,
    "SMILES":"C(C(=O)c1ccc(cc1)F)(C2c3ccc(cc3)Cl)=C(O)C(N2Cc(cccn4)c4)=O",
    "HIT":0.0,
    "question":"Can C(C(=O)c1ccc(cc1)F)(C2c3ccc(cc3)Cl)=C(O)C(N2Cc(cccn4)c4)=O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":61628
  },
  {
    "COADD_ID":"CO-ADD:0220917",
    "INHIB_AVE":-0.65,
    "SMILES":"c(c(Br)c1Br)c(NCC(=O)N\\N=C\\c2cccc(Br)c2)c(c1)Br",
    "HIT":0.0,
    "question":"Does treatment with c(c(Br)c1Br)c(NCC(=O)N\\N=C\\c2cccc(Br)c2)c(c1)Br result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":59910
  },
  {
    "COADD_ID":"CO-ADD:0227133",
    "INHIB_AVE":3.89,
    "SMILES":"N1(c(cc2)ccc2C(C)=O)C(=O)c(c(cc(c3C4=O)C(N4c(cc5)ccc5C(C)=O)=O)C1=O)c3",
    "HIT":0.0,
    "question":"Can N1(c(cc2)ccc2C(C)=O)C(=O)c(c(cc(c3C4=O)C(N4c(cc5)ccc5C(C)=O)=O)C1=O)c3 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":40650
  },
  {
    "COADD_ID":"CO-ADD:0220878",
    "INHIB_AVE":0.52,
    "SMILES":"C(C(=O)N(CC1)CCO1)(C2c3ccccc3)C(C2C(=O)N\\N=C\\c(ccc(c4OCC)O)c4)c5ccccc5",
    "HIT":0.0,
    "question":"Does C(C(=O)N(CC1)CCO1)(C2c3ccccc3)C(C2C(=O)N\\N=C\\c(ccc(c4OCC)O)c4)c5ccccc5 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":55416
  },
  {
    "COADD_ID":"CO-ADD:0301185",
    "INHIB_AVE":-1.57,
    "SMILES":"N1(C2c(cc3)ccc3C(C)C)C(S\\C(=C\/c4ccccc4OCc5ccccc5F)\\C1=O)=NC(C)=C2C(OCC)=O",
    "HIT":0.0,
    "question":"Does the proposed molecule N1(C2c(cc3)ccc3C(C)C)C(S\\C(=C\/c4ccccc4OCc5ccccc5F)\\C1=O)=NC(C)=C2C(OCC)=O exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":62983
  },
  {
    "COADD_ID":"CO-ADD:0293649",
    "INHIB_AVE":-20.08,
    "SMILES":"c1(C)cc(C)ccc1NN.Cl",
    "HIT":0.0,
    "question":"Does treatment with c1(C)cc(C)ccc1NN.Cl result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":82170
  },
  {
    "COADD_ID":"CO-ADD:0227869",
    "INHIB_AVE":6.3,
    "SMILES":"C(C(OCC)=O)(=C1C)\\C(=C\\c(cc2)ccc2C(OC)=O)\\C(N1c3ccc(c(C)c3)C)=O",
    "HIT":0.0,
    "question":"Can C(C(OCC)=O)(=C1C)\\C(=C\\c(cc2)ccc2C(OC)=O)\\C(N1c3ccc(c(C)c3)C)=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":29999
  },
  {
    "COADD_ID":"CO-ADD:0163210",
    "INHIB_AVE":0.19,
    "SMILES":"N(=C(\/C)\\c(cc1)ccc1C(C)(C)C)\/NC(CNc2cccc(C)c2)=O",
    "HIT":0.0,
    "question":"Is N(=C(\/C)\\c(cc1)ccc1C(C)(C)C)\/NC(CNc2cccc(C)c2)=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":56713
  },
  {
    "COADD_ID":"CO-ADD:0135746",
    "INHIB_AVE":-0.45,
    "SMILES":"c1c(NC(NCCC)=S)cccc1",
    "HIT":0.0,
    "question":"Can c1c(NC(NCCC)=S)cccc1 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":59197
  },
  {
    "COADD_ID":"CO-ADD:0329914",
    "INHIB_AVE":-1.09,
    "SMILES":"N1(c2ccccc2)C(=O)c3c(cccn3)C1=O",
    "HIT":0.0,
    "question":"Can N1(c2ccccc2)C(=O)c3c(cccn3)C1=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":61384
  },
  {
    "COADD_ID":"CO-ADD:0136749",
    "INHIB_AVE":8.93,
    "SMILES":"o1c(C(=O)NC(=S)Nc2ccc(S(=O)(=O)N)cc2)ccc1",
    "HIT":0.0,
    "question":"Can exposure to o1c(C(=O)NC(=S)Nc2ccc(S(=O)(=O)N)cc2)ccc1 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":20122
  },
  {
    "COADD_ID":"CO-ADD:0327389",
    "INHIB_AVE":7.22,
    "SMILES":"C12=C(CC(c3ccccc3Cl)CC1=O)Nc(c4NC2c5ccccc5F)cccc4",
    "HIT":0.0,
    "question":"Does the proposed molecule C12=C(CC(c3ccccc3Cl)CC1=O)Nc(c4NC2c5ccccc5F)cccc4 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":26155
  },
  {
    "COADD_ID":"CO-ADD:0296149",
    "INHIB_AVE":1.85,
    "SMILES":"c1(cn(nc1C(N)=O)C)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Can exposure to c1(cn(nc1C(N)=O)C)[N+](=O)[O-] lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":49790
  },
  {
    "COADD_ID":"CO-ADD:0279018",
    "INHIB_AVE":9.84,
    "SMILES":"N1(C)C(=O)\\C(\\SC1=S)=C\/c(ccc(c2OCC)OCc(cc3)ccc3F)c2",
    "HIT":0.0,
    "question":"Does treatment with N1(C)C(=O)\\C(\\SC1=S)=C\/c(ccc(c2OCC)OCc(cc3)ccc3F)c2 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":17454
  },
  {
    "COADD_ID":"CO-ADD:0221304",
    "INHIB_AVE":18.72,
    "SMILES":"n1c(N(CC2)CCO2)nc(nc1N(CC3)CCO3)Nc4nnc(C)s4",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound n1c(N(CC2)CCO2)nc(nc1N(CC3)CCO3)Nc4nnc(C)s4?",
    "answer":"No",
    "_id":3737
  },
  {
    "COADD_ID":"CO-ADD:0291596",
    "INHIB_AVE":0.43,
    "SMILES":"c1(nn(cn1)CC(=O)NC2CCCC2)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Does c1(nn(cn1)CC(=O)NC2CCCC2)[N+](=O)[O-] demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":55749
  },
  {
    "COADD_ID":"CO-ADD:0291090",
    "INHIB_AVE":7.29,
    "SMILES":"C(=O)(c(cccc1C(=O)Nc(cc2)ccc2OCCCCCCCC)c1)Nc(cc3)ccc3OCCCCCCCC",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C(=O)(c(cccc1C(=O)Nc(cc2)ccc2OCCCCCCCC)c1)Nc(cc3)ccc3OCCCCCCCC?",
    "answer":"No",
    "_id":25911
  },
  {
    "COADD_ID":"CO-ADD:0327131",
    "INHIB_AVE":2.14,
    "SMILES":"C(=O)(NCc(cc1)ccc1C(C)(C)C)c(cccc2C(=O)NCc(cc3)ccc3C(C)(C)C)c2",
    "HIT":0.0,
    "question":"Is C(=O)(NCc(cc1)ccc1C(C)(C)C)c(cccc2C(=O)NCc(cc3)ccc3C(C)(C)C)c2 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":48461
  },
  {
    "COADD_ID":"CO-ADD:0320305",
    "INHIB_AVE":-3.14,
    "SMILES":"n1c(CCNC(=O)c(cccc2C(NCCc3scc(c4ccccc4)n3)=O)c2)scc1c5ccccc5",
    "HIT":0.0,
    "question":"Can n1c(CCNC(=O)c(cccc2C(NCCc3scc(c4ccccc4)n3)=O)c2)scc1c5ccccc5 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":67625
  },
  {
    "COADD_ID":"CO-ADD:0221902",
    "INHIB_AVE":5.02,
    "SMILES":"N1(c2ccc(cc2)O)C(=O)c(c3)c(c(c4)C1=O)c(cc3[N+](=O)[O-])cc4[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Can N1(c2ccc(cc2)O)C(=O)c(c3)c(c(c4)C1=O)c(cc3[N+](=O)[O-])cc4[N+](=O)[O-] act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":35559
  },
  {
    "COADD_ID":"CO-ADD:0288068",
    "INHIB_AVE":4.69,
    "SMILES":"S(Cc(cc(C)c(c1)C)c1CS2)C2c3ccc(cc3)Cl",
    "HIT":0.0,
    "question":"Can S(Cc(cc(C)c(c1)C)c1CS2)C2c3ccc(cc3)Cl act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":37066
  },
  {
    "COADD_ID":"CO-ADD:0320884",
    "INHIB_AVE":4.35,
    "SMILES":"c1(c[nH]nc1c(cnn2c3ccccc3)c2)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Is c1(c[nH]nc1c(cnn2c3ccccc3)c2)[N+](=O)[O-] capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":38599
  },
  {
    "COADD_ID":"CO-ADD:0302151",
    "INHIB_AVE":0.05,
    "SMILES":"N1(c2cccc(OC)c2)C(=O)c(c3C1=O)ccc(c3)C4=Nc(c5C(=O)O4)cccc5",
    "HIT":0.0,
    "question":"Does N1(c2cccc(OC)c2)C(=O)c(c3C1=O)ccc(c3)C4=Nc(c5C(=O)O4)cccc5 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":57267
  },
  {
    "COADD_ID":"CO-ADD:0326005",
    "INHIB_AVE":19.26,
    "SMILES":"S(=O)(=O)(N1CCCCC1)c2ccc(c(NS(C)(=O)=O)c2C)C",
    "HIT":0.0,
    "question":"Does the proposed molecule S(=O)(=O)(N1CCCCC1)c2ccc(c(NS(C)(=O)=O)c2C)C exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":3344
  },
  {
    "COADD_ID":"CO-ADD:0329480",
    "INHIB_AVE":6.67,
    "SMILES":"S(=O)(=O)(c(cc1)ccc1C2CCCCC2)NCc(ccc3C(OCC)=O)o3",
    "HIT":0.0,
    "question":"Does the proposed molecule S(=O)(=O)(c(cc1)ccc1C2CCCCC2)NCc(ccc3C(OCC)=O)o3 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":28414
  },
  {
    "COADD_ID":"CO-ADD:0259739",
    "INHIB_AVE":2.51,
    "SMILES":"N1=C(SCC(=O)Nc(cc2)ccc2C(OC)=O)NC(C(c3ccccc3)C1=O)=O",
    "HIT":0.0,
    "question":"Does N1=C(SCC(=O)Nc(cc2)ccc2C(OC)=O)NC(C(c3ccccc3)C1=O)=O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":46837
  },
  {
    "COADD_ID":"CO-ADD:0300376",
    "INHIB_AVE":1.19,
    "SMILES":"C(=O)(c(ccc(c12)OCO1)c2)N(CC3)CCC3C(N)=O",
    "HIT":0.0,
    "question":"Does the proposed molecule C(=O)(c(ccc(c12)OCO1)c2)N(CC3)CCC3C(N)=O exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":52662
  },
  {
    "COADD_ID":"CO-ADD:0236343",
    "INHIB_AVE":11.54,
    "SMILES":"c1(C#N)c(SCC(N)=O)nsc1SCC(N)=O",
    "HIT":0.0,
    "question":"Does treatment with c1(C#N)c(SCC(N)=O)nsc1SCC(N)=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":13362
  },
  {
    "COADD_ID":"CO-ADD:0136951",
    "INHIB_AVE":6.49,
    "SMILES":"N(c(cc1)ccc1C)=Nc2ccc(C)cc2NC(Nc(c(ccc3)F)c3)=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound N(c(cc1)ccc1C)=Nc2ccc(C)cc2NC(Nc(c(ccc3)F)c3)=O?",
    "answer":"No",
    "_id":29181
  },
  {
    "COADD_ID":"CO-ADD:0321372",
    "INHIB_AVE":-11.01,
    "SMILES":"C(=O)(NC(CC1(C)C)CC(N1)(C)C)c(c2)cc(cn2)Br",
    "HIT":0.0,
    "question":"Can C(=O)(NC(CC1(C)C)CC(N1)(C)C)c(c2)cc(cn2)Br act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":79434
  },
  {
    "COADD_ID":"CO-ADD:0220241",
    "INHIB_AVE":0.64,
    "SMILES":"[N+](=O)([O-])c1cccc(OCC(=O)N\\N=C\\c2cc(Br)cc(C)c2O)c1",
    "HIT":0.0,
    "question":"Is [N+](=O)([O-])c1cccc(OCC(=O)N\\N=C\\c2cc(Br)cc(C)c2O)c1 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":54934
  },
  {
    "COADD_ID":"CO-ADD:0318929",
    "INHIB_AVE":7.08,
    "SMILES":"N1(c2ccc(cc2)F)C(=O)\\C(\\SC1=N)=C\\c(cc3)ccc3OCc4ccccc4F",
    "HIT":0.0,
    "question":"Can exposure to N1(c2ccc(cc2)F)C(=O)\\C(\\SC1=N)=C\\c(cc3)ccc3OCc4ccccc4F lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":26673
  },
  {
    "COADD_ID":"CO-ADD:0233049",
    "INHIB_AVE":3.08,
    "SMILES":"N1(c2ccc(cc2)F)CC(CC1=O)C(=O)OCC(c3ccccc3)=O",
    "HIT":0.0,
    "question":"Does N1(c2ccc(cc2)F)CC(CC1=O)C(=O)OCC(c3ccccc3)=O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":44276
  },
  {
    "COADD_ID":"CO-ADD:0312248",
    "INHIB_AVE":6.87,
    "SMILES":"C(C(OCCOC)=O)(=C(C)NC(=C12)CC(CC1=O)c3cccs3)C2c(cc4OC)cc(c4OC)OC",
    "HIT":0.0,
    "question":"Does C(C(OCCOC)=O)(=C(C)NC(=C12)CC(CC1=O)c3cccs3)C2c(cc4OC)cc(c4OC)OC show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":27508
  },
  {
    "COADD_ID":"CO-ADD:0229073",
    "INHIB_AVE":3.74,
    "SMILES":"[N+](=O)([O-])c(ccc(c1\\C=N\\NC(=O)c(cccc2NC(=O)c3ccc(cc3)OC)c2)OCC)c1",
    "HIT":0.0,
    "question":"Can exposure to [N+](=O)([O-])c(ccc(c1\\C=N\\NC(=O)c(cccc2NC(=O)c3ccc(cc3)OC)c2)OCC)c1 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":41309
  },
  {
    "COADD_ID":"CO-ADD:0233206",
    "INHIB_AVE":16.56,
    "SMILES":"N1(C(c2ccccc2)CC(O)=O)C(=O)c3c(cc(cc3)F)C1=O",
    "HIT":0.0,
    "question":"Is N1(C(c2ccccc2)CC(O)=O)C(=O)c3c(cc(cc3)F)C1=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":5746
  },
  {
    "COADD_ID":"CO-ADD:0243387",
    "INHIB_AVE":14.56,
    "SMILES":"C12=C(OC(=O)CC1c(cc3OC)cc(c34)OCO4)c5c(cccc5)NC2=O",
    "HIT":0.0,
    "question":"Does C12=C(OC(=O)CC1c(cc3OC)cc(c34)OCO4)c5c(cccc5)NC2=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":8168
  },
  {
    "COADD_ID":"CO-ADD:0258520",
    "INHIB_AVE":9.85,
    "SMILES":"[N+](=O)([O-])c(ccc(c1\\C=N\\c(ccc(c2N3)NC3=O)c2)Cl)c1",
    "HIT":0.0,
    "question":"Does [N+](=O)([O-])c(ccc(c1\\C=N\\c(ccc(c2N3)NC3=O)c2)Cl)c1 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":17427
  },
  {
    "COADD_ID":"CO-ADD:0160025",
    "INHIB_AVE":8.04,
    "SMILES":"ClC(C=C1)=C(C=C1\/N=C\\C2=CC(Br)=CC=C2O)C3=NC(C=C4)=C(C=C4C)O3",
    "HIT":0.0,
    "question":"Is ClC(C=C1)=C(C=C1\/N=C\\C2=CC(Br)=CC=C2O)C3=NC(C=C4)=C(C=C4C)O3 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":23053
  },
  {
    "COADD_ID":"CO-ADD:0155120",
    "INHIB_AVE":0.23,
    "SMILES":"[O-][N+](C1=CSC(C(C(C2=O)=C(C3=CC=CC=C3O2)O4)C(C(OCC)=O)=C4N)=C1)=O",
    "HIT":0.0,
    "question":"Does [O-][N+](C1=CSC(C(C(C2=O)=C(C3=CC=CC=C3O2)O4)C(C(OCC)=O)=C4N)=C1)=O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":56549
  },
  {
    "COADD_ID":"CO-ADD:0299607",
    "INHIB_AVE":1.87,
    "SMILES":"C(C(=O)c1ccc(cc1)C)(C2c3ccc(c4c3)OCO4)=C(O)C(N2CCC(O)=O)=O",
    "HIT":0.0,
    "question":"Can C(C(=O)c1ccc(cc1)C)(C2c3ccc(c4c3)OCO4)=C(O)C(N2CCC(O)=O)=O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":49716
  },
  {
    "COADD_ID":"CO-ADD:0156134",
    "INHIB_AVE":4.16,
    "SMILES":"O=C(NC1=CC(C)=C(C)C=C1)C2C(C3=CC=CC=C3)(C4=CC=CC=C4)C2",
    "HIT":0.0,
    "question":"Can O=C(NC1=CC(C)=C(C)C=C1)C2C(C3=CC=CC=C3)(C4=CC=CC=C4)C2 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":39460
  },
  {
    "COADD_ID":"CO-ADD:0290602",
    "INHIB_AVE":3.48,
    "SMILES":"S(=O)(=O)(c1ccc(cc1)Cl)NC(C(Cl)(Cl)Cl)c2c3c([nH]c2C)cccc3.Cl",
    "HIT":0.0,
    "question":"Can S(=O)(=O)(c1ccc(cc1)Cl)NC(C(Cl)(Cl)Cl)c2c3c([nH]c2C)cccc3.Cl effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":42453
  },
  {
    "COADD_ID":"CO-ADD:0286976",
    "INHIB_AVE":-8.85,
    "SMILES":"c1(C(OCC)=O)c(cc(OC(C)=O)c(c2)Br)c2n(C)c1CSc3nc(C)c(c(C)c3C#N)CC",
    "HIT":0.0,
    "question":"Is c1(C(OCC)=O)c(cc(OC(C)=O)c(c2)Br)c2n(C)c1CSc3nc(C)c(c(C)c3C#N)CC capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":77687
  },
  {
    "COADD_ID":"CO-ADD:0218715",
    "INHIB_AVE":9.71,
    "SMILES":"C(=O)(N\\N=C\\c1ccc(cc1O)C)C(O)c2ccccc2",
    "HIT":0.0,
    "question":"Does C(=O)(N\\N=C\\c1ccc(cc1O)C)C(O)c2ccccc2 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":17834
  },
  {
    "COADD_ID":"CO-ADD:0324083",
    "INHIB_AVE":7.23,
    "SMILES":"c1(nc(C)nc2N(CC3)CCO3)c2OCC(=O)N1",
    "HIT":0.0,
    "question":"Can c1(nc(C)nc2N(CC3)CCO3)c2OCC(=O)N1 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":26141
  },
  {
    "COADD_ID":"CO-ADD:0291739",
    "INHIB_AVE":0.76,
    "SMILES":"C12(SCC(=O)N1c3ccc(cc3C)C)c4c(NC2=O)cccc4",
    "HIT":0.0,
    "question":"Is C12(SCC(=O)N1c3ccc(cc3C)C)c4c(NC2=O)cccc4 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":54456
  },
  {
    "COADD_ID":"CO-ADD:0233645",
    "INHIB_AVE":-7.3,
    "SMILES":"[N+](=O)([O-])c(cc1\\C=N\\NC(COc(cc2)c(Br)cc2[N+](=O)[O-])=O)cc(c1OC(=O)c3ccc(cc3)Br)Br",
    "HIT":0.0,
    "question":"Does [N+](=O)([O-])c(cc1\\C=N\\NC(COc(cc2)c(Br)cc2[N+](=O)[O-])=O)cc(c1OC(=O)c3ccc(cc3)Br)Br show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":75762
  },
  {
    "COADD_ID":"CO-ADD:0253309",
    "INHIB_AVE":7.6,
    "SMILES":"C(CSCc(cc1)ccc1OC)(=O)N\\N=C\\c2cccc(OC)c2OC",
    "HIT":0.0,
    "question":"Can C(CSCc(cc1)ccc1OC)(=O)N\\N=C\\c2cccc(OC)c2OC effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":24683
  },
  {
    "COADD_ID":"CO-ADD:0302167",
    "INHIB_AVE":-6.85,
    "SMILES":"C1(CCC(NC1c(ccc(c23)OCO2)c3)=O)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Does treatment with C1(CCC(NC1c(ccc(c23)OCO2)c3)=O)[N+](=O)[O-] result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":75108
  },
  {
    "COADD_ID":"CO-ADD:0294372",
    "INHIB_AVE":5.65,
    "SMILES":"C1(c2ccc(cc2C)NC(=O)c3cc(c4o3)cccc4)=Cc5c(OC1=O)cccc5",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C1(c2ccc(cc2C)NC(=O)c3cc(c4o3)cccc4)=Cc5c(OC1=O)cccc5?",
    "answer":"No",
    "_id":32731
  },
  {
    "COADD_ID":"CO-ADD:0331191",
    "INHIB_AVE":-1.86,
    "SMILES":"n1(c2c(n3)cccc2)c3COCC(O)C1",
    "HIT":0.0,
    "question":"Does n1(c2c(n3)cccc2)c3COCC(O)C1 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":63923
  },
  {
    "COADD_ID":"CO-ADD:0245732",
    "INHIB_AVE":-7.82,
    "SMILES":"n1(c(C)c(nn1)\\C(\\C)=N\\N=C\\c2cccs2)c3nonc3N",
    "HIT":0.0,
    "question":"Is n1(c(C)c(nn1)\\C(\\C)=N\\N=C\\c2cccs2)c3nonc3N effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":76503
  },
  {
    "COADD_ID":"CO-ADD:0303156",
    "INHIB_AVE":5.43,
    "SMILES":"C(=C\/c(ccc(c1OC)OCCSc2cccc(cccc3)c23)c1)(\/C(=O)N(C)C(N4C)=O)\\C4=O",
    "HIT":0.0,
    "question":"Does treatment with C(=C\/c(ccc(c1OC)OCCSc2cccc(cccc3)c23)c1)(\/C(=O)N(C)C(N4C)=O)\\C4=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":33782
  },
  {
    "COADD_ID":"CO-ADD:0154797",
    "INHIB_AVE":4.16,
    "SMILES":"O=C(C1=CC(C2=O)=C3C(N2CCOC4=CC(C)=C(C)C=C4)=O)N(CCOC5=CC(C)=C(C)C=C5)C(C1=C3)=O",
    "HIT":0.0,
    "question":"Does O=C(C1=CC(C2=O)=C3C(N2CCOC4=CC(C)=C(C)C=C4)=O)N(CCOC5=CC(C)=C(C)C=C5)C(C1=C3)=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":39454
  },
  {
    "COADD_ID":"CO-ADD:0330741",
    "INHIB_AVE":-12.23,
    "SMILES":"c1(nc(c2ccc(c(OC)c2)OC)cc3C(F)(F)F)n3ncc1C(=O)NCC(CC(CC4C5)CC56)(C6)C4",
    "HIT":0.0,
    "question":"Does the proposed molecule c1(nc(c2ccc(c(OC)c2)OC)cc3C(F)(F)F)n3ncc1C(=O)NCC(CC(CC4C5)CC56)(C6)C4 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":80172
  },
  {
    "COADD_ID":"CO-ADD:0228417",
    "INHIB_AVE":2.71,
    "SMILES":"N12c(c(C3C(CCC3)C1)c4)c(C5C(CCC5)C2)cc4NC(=O)c6ccc(cc6)C",
    "HIT":0.0,
    "question":"Can exposure to N12c(c(C3C(CCC3)C1)c4)c(C5C(CCC5)C2)cc4NC(=O)c6ccc(cc6)C lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":45919
  },
  {
    "COADD_ID":"CO-ADD:0234156",
    "INHIB_AVE":1.63,
    "SMILES":"n1c2c(oc1c3ccc(cc3)\\N=C\\c(ccc(c4[N+](=O)[O-])Br)c4)cccc2C",
    "HIT":0.0,
    "question":"Does n1c2c(oc1c3ccc(cc3)\\N=C\\c(ccc(c4[N+](=O)[O-])Br)c4)cccc2C show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":50761
  },
  {
    "COADD_ID":"CO-ADD:0324568",
    "INHIB_AVE":9.26,
    "SMILES":"N1(c2ccc(cc2)OC)C(=O)C(CC1=O)NCCOC(CC3CC4CC5C3)(C5)C4",
    "HIT":0.0,
    "question":"Can N1(c2ccc(cc2)OC)C(=O)C(CC1=O)NCCOC(CC3CC4CC5C3)(C5)C4 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":19157
  },
  {
    "COADD_ID":"CO-ADD:0328229",
    "INHIB_AVE":-0.33,
    "SMILES":"S(c1ccccc1)(=O)(=O)c2c(O)c(C)cc(NS(=O)(=O)c(cccc3[N+](=O)[O-])c3)c2C(C)C",
    "HIT":0.0,
    "question":"Can S(c1ccccc1)(=O)(=O)c2c(O)c(C)cc(NS(=O)(=O)c(cccc3[N+](=O)[O-])c3)c2C(C)C effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":58710
  },
  {
    "COADD_ID":"CO-ADD:0256410",
    "INHIB_AVE":5.83,
    "SMILES":"N(CC1)(CCN1CCOc2ccccc2OC)c3ccccc3C",
    "HIT":0.0,
    "question":"Does N(CC1)(CCN1CCOc2ccccc2OC)c3ccccc3C show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":31959
  },
  {
    "COADD_ID":"CO-ADD:0284780",
    "INHIB_AVE":19.81,
    "SMILES":"c1(nc(c2n1Cc(ccc(c3Cl)Cl)c3)cccc2)\\C=C(\\c4ccccc4F)\/OC(=O)c5ccccc5F",
    "HIT":0.0,
    "question":"Does treatment with c1(nc(c2n1Cc(ccc(c3Cl)Cl)c3)cccc2)\\C=C(\\c4ccccc4F)\/OC(=O)c5ccccc5F result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":2995
  },
  {
    "COADD_ID":"CO-ADD:0327296",
    "INHIB_AVE":7.14,
    "SMILES":"C1(OCC(CO1)(CO2)COC2(c3c(N4CN(CC5)CCO5)cccc3)C4=O)(c6c(N7CN(CC8)CCO8)cccc6)C7=O",
    "HIT":0.0,
    "question":"Does C1(OCC(CO1)(CO2)COC2(c3c(N4CN(CC5)CCO5)cccc3)C4=O)(c6c(N7CN(CC8)CCO8)cccc6)C7=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":26459
  },
  {
    "COADD_ID":"CO-ADD:0259705",
    "INHIB_AVE":5.55,
    "SMILES":"N1(C2c3ccc(c(OC)c3)OC)C(S\\C(=C\\c4cc(Cl)ccc4O)\\C1=O)=NC(C)=C2C(OCC)=O",
    "HIT":0.0,
    "question":"Does the proposed molecule N1(C2c3ccc(c(OC)c3)OC)C(S\\C(=C\\c4cc(Cl)ccc4O)\\C1=O)=NC(C)=C2C(OCC)=O exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":33167
  },
  {
    "COADD_ID":"CO-ADD:0332165",
    "INHIB_AVE":-1.82,
    "SMILES":"C(=O)(c(ccc(c1Cl)Cl)c1)NC(C)(CC)C#C",
    "HIT":0.0,
    "question":"Does treatment with C(=O)(c(ccc(c1Cl)Cl)c1)NC(C)(CC)C#C result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":63824
  },
  {
    "COADD_ID":"CO-ADD:0162583",
    "INHIB_AVE":11.05,
    "SMILES":"C(NCCCCCNC(=O)c1ccc(cc1)Cl)(=O)c2ccc(cc2)Cl",
    "HIT":0.0,
    "question":"Can C(NCCCCCNC(=O)c1ccc(cc1)Cl)(=O)c2ccc(cc2)Cl effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":14412
  },
  {
    "COADD_ID":"CO-ADD:0254757",
    "INHIB_AVE":5.79,
    "SMILES":"c(C#N)(c(\\C(\\C#N)=C\\c(c(cccc1)c1n2Cc3ccccc3)c2)nn4c5ccccc5)c4N",
    "HIT":0.0,
    "question":"Does c(C#N)(c(\\C(\\C#N)=C\\c(c(cccc1)c1n2Cc3ccccc3)c2)nn4c5ccccc5)c4N demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":32133
  },
  {
    "COADD_ID":"CO-ADD:0279104",
    "INHIB_AVE":-8.97,
    "SMILES":"C(=O)(Nc1ccccc1O)c(c2c3cccc2)c4c(n3)CCCC4",
    "HIT":0.0,
    "question":"Can exposure to C(=O)(Nc1ccccc1O)c(c2c3cccc2)c4c(n3)CCCC4 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":77826
  },
  {
    "COADD_ID":"CO-ADD:0165844",
    "INHIB_AVE":-5.12,
    "SMILES":"C(C)(=C(C(=O)C)C1C(C(C(C)(C)C23)C2)=CC3)NC(=O)N1",
    "HIT":0.0,
    "question":"Can C(C)(=C(C(=O)C)C1C(C(C(C)(C)C23)C2)=CC3)NC(=O)N1 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":72108
  },
  {
    "COADD_ID":"CO-ADD:0306075",
    "INHIB_AVE":5.46,
    "SMILES":"C(NC(C)=O)(C(F)(F)F)(C(F)(F)F)Nc1sc(c2c1C(N)=O)CCC2",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C(NC(C)=O)(C(F)(F)F)(C(F)(F)F)Nc1sc(c2c1C(N)=O)CCC2?",
    "answer":"No",
    "_id":33639
  },
  {
    "COADD_ID":"CO-ADD:0220792",
    "INHIB_AVE":8.38,
    "SMILES":"C(CNc1cccc(C)c1)(=O)N\\N=C\\c(ccc(c2OCC)O)c2",
    "HIT":0.0,
    "question":"Does C(CNc1cccc(C)c1)(=O)N\\N=C\\c(ccc(c2OCC)O)c2 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":21855
  },
  {
    "COADD_ID":"CO-ADD:0161621",
    "INHIB_AVE":6.98,
    "SMILES":"c1(cc(C)ccc1C(C)C)OCC(=O)N\\N=C\\C=C\\c2ccc(C)o2",
    "HIT":0.0,
    "question":"Does c1(cc(C)ccc1C(C)C)OCC(=O)N\\N=C\\C=C\\c2ccc(C)o2 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":27067
  },
  {
    "COADD_ID":"CO-ADD:0255448",
    "INHIB_AVE":3.94,
    "SMILES":"c1(NC(=O)\\C=C\\CCCCC)sc2c(ccc(OCC)c2)n1",
    "HIT":0.0,
    "question":"Does c1(NC(=O)\\C=C\\CCCCC)sc2c(ccc(OCC)c2)n1 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":40405
  },
  {
    "COADD_ID":"CO-ADD:0223347",
    "INHIB_AVE":14.96,
    "SMILES":"c1(SCC(=O)N\\N=C\\c(ccc(c23)OCO2)c3)sc(c4n1)cccc4",
    "HIT":0.0,
    "question":"Does the proposed molecule c1(SCC(=O)N\\N=C\\c(ccc(c23)OCO2)c3)sc(c4n1)cccc4 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":7644
  },
  {
    "COADD_ID":"CO-ADD:0241788",
    "INHIB_AVE":6.88,
    "SMILES":"C(C#N)(C1c(cc2)ccc2C(F)(F)F)=C(N)SC(N)=C1C#N",
    "HIT":0.0,
    "question":"Can exposure to C(C#N)(C1c(cc2)ccc2C(F)(F)F)=C(N)SC(N)=C1C#N lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":27492
  },
  {
    "COADD_ID":"CO-ADD:0323715",
    "INHIB_AVE":-0.24,
    "SMILES":"N(C(C)=O)(c1c(C2C3C(=O)Nc(c4S3)cccc4)cc(Br)cc1)C2=O",
    "HIT":0.0,
    "question":"Does N(C(C)=O)(c1c(C2C3C(=O)Nc(c4S3)cccc4)cc(Br)cc1)C2=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":58391
  },
  {
    "COADD_ID":"CO-ADD:0255812",
    "INHIB_AVE":18.58,
    "SMILES":"c1(Nc2cccc(C)c2)sc(c3n1)CCC3",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(Nc2cccc(C)c2)sc(c3n1)CCC3?",
    "answer":"No",
    "_id":3842
  },
  {
    "COADD_ID":"CO-ADD:0291266",
    "INHIB_AVE":5.53,
    "SMILES":"C1(=C(CC(C)(C)CC1=O)OC(=C23)CC(CC2=O)(C)C)C3c4ccc(cc4F)F",
    "HIT":0.0,
    "question":"Can C1(=C(CC(C)(C)CC1=O)OC(=C23)CC(CC2=O)(C)C)C3c4ccc(cc4F)F effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":33286
  },
  {
    "COADD_ID":"CO-ADD:0250736",
    "INHIB_AVE":18.78,
    "SMILES":"S(=O)(=O)(N1CCCC1)c2c(C)ccc(c2)C(=O)Nc(cccc3[N+](=O)[O-])c3",
    "HIT":0.0,
    "question":"Can S(=O)(=O)(N1CCCC1)c2c(C)ccc(c2)C(=O)Nc(cccc3[N+](=O)[O-])c3 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":3694
  },
  {
    "COADD_ID":"CO-ADD:0157607",
    "INHIB_AVE":14.59,
    "SMILES":"[O-][N+](C1=C(Cl)C=CC(C(NC(C=C2)=CC=C2OCC(F)(F)C(F)(F)C(F)(F)C(F)F)=O)=C1)=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound [O-][N+](C1=C(Cl)C=CC(C(NC(C=C2)=CC=C2OCC(F)(F)C(F)(F)C(F)(F)C(F)F)=O)=C1)=O?",
    "answer":"No",
    "_id":8130
  },
  {
    "COADD_ID":"CO-ADD:0228626",
    "INHIB_AVE":-17.1,
    "SMILES":"[N+](=O)([O-])c(cc1)ccc1c2csc(C)n2",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound [N+](=O)([O-])c(cc1)ccc1c2csc(C)n2?",
    "answer":"No",
    "_id":81768
  },
  {
    "COADD_ID":"CO-ADD:0257296",
    "INHIB_AVE":0.73,
    "SMILES":"c1(O)c(I)cc(cc1I)\\C=N\\NC(=O)c2ccc(cc2)Oc(cc3)ccc3O",
    "HIT":0.0,
    "question":"Does treatment with c1(O)c(I)cc(cc1I)\\C=N\\NC(=O)c2ccc(cc2)Oc(cc3)ccc3O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":54615
  },
  {
    "COADD_ID":"CO-ADD:0327933",
    "INHIB_AVE":26.26,
    "SMILES":"c1(C2=O)c(NC(c3ccco3)N2Cc4ccccc4)c(c5s1)c(COC)cc(C)n5",
    "HIT":0.0,
    "question":"Can c1(C2=O)c(NC(c3ccco3)N2Cc4ccccc4)c(c5s1)c(COC)cc(C)n5 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":1017
  },
  {
    "COADD_ID":"CO-ADD:0232922",
    "INHIB_AVE":11.75,
    "SMILES":"S(c1ccccc1)(=O)(=O)N(c(cccc2C(F)(F)F)c2)CC(=O)NCC(C)C",
    "HIT":0.0,
    "question":"Can S(c1ccccc1)(=O)(=O)N(c(cccc2C(F)(F)F)c2)CC(=O)NCC(C)C act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":12944
  },
  {
    "COADD_ID":"CO-ADD:0283745",
    "INHIB_AVE":-6.07,
    "SMILES":"N1(c2cccc(c2)C(=O)Nc(cc(cc3C(O)=O)C(O)=O)c3)C(=O)c4c(c(ccc5[N+](=O)[O-])C1=O)c5ccc4",
    "HIT":0.0,
    "question":"Does N1(c2cccc(c2)C(=O)Nc(cc(cc3C(O)=O)C(O)=O)c3)C(=O)c4c(c(ccc5[N+](=O)[O-])C1=O)c5ccc4 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":73873
  },
  {
    "COADD_ID":"CO-ADD:0247624",
    "INHIB_AVE":9.83,
    "SMILES":"S(CCCCCCCCCC)(=O)(=O)Nc(c1)cc2c(cccc2)n1",
    "HIT":0.0,
    "question":"Can S(CCCCCCCCCC)(=O)(=O)Nc(c1)cc2c(cccc2)n1 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":17503
  },
  {
    "COADD_ID":"CO-ADD:0149648",
    "INHIB_AVE":4.94,
    "SMILES":"CC1=C(C(C2=CC=CC=C2OC)C3=C(N=C(CCCC4)C4=C3N)N1)C(OCC)=O",
    "HIT":0.0,
    "question":"Does treatment with CC1=C(C(C2=CC=CC=C2OC)C3=C(N=C(CCCC4)C4=C3N)N1)C(OCC)=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":35911
  },
  {
    "COADD_ID":"CO-ADD:0329249",
    "INHIB_AVE":26.61,
    "SMILES":"C1(C)(CCC2=O)N2c(c3C(=O)N1c4ccccc4)cccc3",
    "HIT":0.0,
    "question":"Does the proposed molecule C1(C)(CCC2=O)N2c(c3C(=O)N1c4ccccc4)cccc3 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":978
  },
  {
    "COADD_ID":"CO-ADD:0225654",
    "INHIB_AVE":2.93,
    "SMILES":"C1(=N2)N(C=CN=C1Oc3cccc(OC)c3)C(N2CC(=O)Nc(ccc(c45)OCCO4)c5)=O",
    "HIT":0.0,
    "question":"Can C1(=N2)N(C=CN=C1Oc3cccc(OC)c3)C(N2CC(=O)Nc(ccc(c45)OCCO4)c5)=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":44986
  },
  {
    "COADD_ID":"CO-ADD:0135944",
    "INHIB_AVE":20.74,
    "SMILES":"n1cc2c(c(c(cccc3)c34)ccc2)c4c1",
    "HIT":0.0,
    "question":"Is n1cc2c(c(c(cccc3)c34)ccc2)c4c1 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":2461
  },
  {
    "COADD_ID":"CO-ADD:0246201",
    "INHIB_AVE":4.92,
    "SMILES":"C(C(=O)c1ccc(cc1)Br)C(=O)Oc(cc2)ccc2\\N=C\\c3cc(OC)ccc3O",
    "HIT":0.0,
    "question":"Does treatment with C(C(=O)c1ccc(cc1)Br)C(=O)Oc(cc2)ccc2\\N=C\\c3cc(OC)ccc3O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":36010
  },
  {
    "COADD_ID":"CO-ADD:0243931",
    "INHIB_AVE":18.37,
    "SMILES":"C(C)(=C1)OC(=O)C(C(c(cc2c3OCO2)cc3OC)CC(=O)NCCc4nc[nH]c4)=C1O",
    "HIT":0.0,
    "question":"Does the proposed molecule C(C)(=C1)OC(=O)C(C(c(cc2c3OCO2)cc3OC)CC(=O)NCCc4nc[nH]c4)=C1O exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":4005
  },
  {
    "COADD_ID":"CO-ADD:0284850",
    "INHIB_AVE":7.78,
    "SMILES":"N1(C2c(cc3)ccc3N(C)C)C(S\\C(=C\\c4cc(Br)ccc4OCc5ccccc5)\\C1=O)=NC(C)=C2C(OCC)=O",
    "HIT":0.0,
    "question":"Does the proposed molecule N1(C2c(cc3)ccc3N(C)C)C(S\\C(=C\\c4cc(Br)ccc4OCc5ccccc5)\\C1=O)=NC(C)=C2C(OCC)=O exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":24041
  },
  {
    "COADD_ID":"CO-ADD:0243763",
    "INHIB_AVE":5.19,
    "SMILES":"N1(C(=O)C(O)=C(C1c(cc2c(c3OC)OCO2)c3OC)C(=O)c4cc5c(OCCO5)cc4)CCN6CCCC6",
    "HIT":0.0,
    "question":"Does the proposed molecule N1(C(=O)C(O)=C(C1c(cc2c(c3OC)OCO2)c3OC)C(=O)c4cc5c(OCCO5)cc4)CCN6CCCC6 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":34780
  },
  {
    "COADD_ID":"CO-ADD:0245539",
    "INHIB_AVE":3.71,
    "SMILES":"N1(c2cc(C)ccc2C)C(=O)c3c(c4C1=O)c(c5cc3)c(cc4)CC5",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound N1(c2cc(C)ccc2C)C(=O)c3c(c4C1=O)c(c5cc3)c(cc4)CC5?",
    "answer":"No",
    "_id":41467
  },
  {
    "COADD_ID":"CO-ADD:0328292",
    "INHIB_AVE":6.67,
    "SMILES":"C1(=Cc2c(OC1=O)ccc(OC)c2)C(=O)N(CC3)CCN3c4ccc(cc4)C",
    "HIT":0.0,
    "question":"Is C1(=Cc2c(OC1=O)ccc(OC)c2)C(=O)N(CC3)CCN3c4ccc(cc4)C capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":28416
  },
  {
    "COADD_ID":"CO-ADD:0160008",
    "INHIB_AVE":-0.89,
    "SMILES":"[O-][N+](C1=CC(NCN2C(OC3=C2C=CC(Br)=C3)=O)=CC=C1)=O",
    "HIT":0.0,
    "question":"Does treatment with [O-][N+](C1=CC(NCN2C(OC3=C2C=CC(Br)=C3)=O)=CC=C1)=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":60755
  },
  {
    "COADD_ID":"CO-ADD:0287393",
    "INHIB_AVE":4.59,
    "SMILES":"C(=O)(Oc(cc1)c(OCC)cc1C(=S)N2CCC(CC2)C)c3ccccc3Br",
    "HIT":0.0,
    "question":"Is C(=O)(Oc(cc1)c(OCC)cc1C(=S)N2CCC(CC2)C)c3ccccc3Br effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":37517
  },
  {
    "COADD_ID":"CO-ADD:0149798",
    "INHIB_AVE":11.2,
    "SMILES":"CC(C=C1)=CC=C1S(N2[C@@H]3CC[C@H]2CC3)(=O)=O",
    "HIT":0.0,
    "question":"Is CC(C=C1)=CC=C1S(N2[C@@H]3CC[C@H]2CC3)(=O)=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":14084
  },
  {
    "COADD_ID":"CO-ADD:0241862",
    "INHIB_AVE":-3.77,
    "SMILES":"c1(N(CC2)CCO2)nc(N\\N=C\\c3ccccc3C(F)(F)F)nc(NCc4ccccc4)n1.Cl",
    "HIT":0.0,
    "question":"Can exposure to c1(N(CC2)CCO2)nc(N\\N=C\\c3ccccc3C(F)(F)F)nc(NCc4ccccc4)n1.Cl lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":69201
  },
  {
    "COADD_ID":"CO-ADD:0252453",
    "INHIB_AVE":8.65,
    "SMILES":"c1(SCC(OCC(=O)Nc(cc2)ccc2OC)=O)nc(C)cc(C)n1",
    "HIT":0.0,
    "question":"Can exposure to c1(SCC(OCC(=O)Nc(cc2)ccc2OC)=O)nc(C)cc(C)n1 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":21008
  },
  {
    "COADD_ID":"CO-ADD:0300286",
    "INHIB_AVE":1.15,
    "SMILES":"C(=C\/c1ccc[nH]1)(\/C(=O)NC(N2CC)=S)\\C2=O",
    "HIT":0.0,
    "question":"Does treatment with C(=C\/c1ccc[nH]1)(\/C(=O)NC(N2CC)=S)\\C2=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":52841
  },
  {
    "COADD_ID":"CO-ADD:0248694",
    "INHIB_AVE":10.57,
    "SMILES":"ClC(C=C1)=CC=C1C2=NN=C3C=NC=C(OCCC4=CC=CC=C4)N32",
    "HIT":0.0,
    "question":"Can ClC(C=C1)=CC=C1C2=NN=C3C=NC=C(OCCC4=CC=CC=C4)N32 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":15553
  },
  {
    "COADD_ID":"CO-ADD:0154815",
    "INHIB_AVE":3.64,
    "SMILES":"SC1=NN=C(C2=CC=C(OC)C=C2)O1",
    "HIT":0.0,
    "question":"Does SC1=NN=C(C2=CC=C(OC)C=C2)O1 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":41783
  },
  {
    "COADD_ID":"CO-ADD:0228247",
    "INHIB_AVE":-1.14,
    "SMILES":"n1c(c2ccccc2)nnn1CC(=O)N\\N=C\\c(ccc3c4ccc(cc4)Br)o3",
    "HIT":0.0,
    "question":"Is n1c(c2ccccc2)nnn1CC(=O)N\\N=C\\c(ccc3c4ccc(cc4)Br)o3 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":61561
  },
  {
    "COADD_ID":"CO-ADD:0218616",
    "INHIB_AVE":9.8,
    "SMILES":"C(NCCO)(=O)c(cc1)ccc1C(NCCO)=O",
    "HIT":0.0,
    "question":"Can exposure to C(NCCO)(=O)c(cc1)ccc1C(NCCO)=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":17568
  },
  {
    "COADD_ID":"CO-ADD:0332243",
    "INHIB_AVE":18.54,
    "SMILES":"C1(=C(N2CCCCC2)C(c(cccc3)c3C1=O)=O)n4c5c(nn4)cccc5",
    "HIT":0.0,
    "question":"Does the proposed molecule C1(=C(N2CCCCC2)C(c(cccc3)c3C1=O)=O)n4c5c(nn4)cccc5 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":3869
  },
  {
    "COADD_ID":"CO-ADD:0154598",
    "INHIB_AVE":6.26,
    "SMILES":"O=CC(C=C1)=CC=C1OCCO[N+]([O-])=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound O=CC(C=C1)=CC=C1OCCO[N+]([O-])=O?",
    "answer":"No",
    "_id":30153
  },
  {
    "COADD_ID":"CO-ADD:0293647",
    "INHIB_AVE":-4.58,
    "SMILES":"c1(Cl)c(cccc1NN)Cl.Cl",
    "HIT":0.0,
    "question":"Can exposure to c1(Cl)c(cccc1NN)Cl.Cl lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":71007
  },
  {
    "COADD_ID":"CO-ADD:0229931",
    "INHIB_AVE":8.39,
    "SMILES":"[N+](=O)([O-])c(cc1)ccc1C(=O)Oc(ccc(c23)OC(C=C2C)=O)c3",
    "HIT":0.0,
    "question":"Is [N+](=O)([O-])c(cc1)ccc1C(=O)Oc(ccc(c23)OC(C=C2C)=O)c3 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":21830
  },
  {
    "COADD_ID":"CO-ADD:0321503",
    "INHIB_AVE":1.06,
    "SMILES":"n1(c2c(C)cccc2C)nnnc1CN(Cc3ccccc3)Cc4ccccc4",
    "HIT":0.0,
    "question":"Can n1(c2c(C)cccc2C)nnnc1CN(Cc3ccccc3)Cc4ccccc4 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":53183
  },
  {
    "COADD_ID":"CO-ADD:0277489",
    "INHIB_AVE":3.69,
    "SMILES":"C(C(c1ccccc1)=O)(Sc2cc(C)nc(C(C)C)n2)NC(c3ccccc3)=O",
    "HIT":0.0,
    "question":"Can C(C(c1ccccc1)=O)(Sc2cc(C)nc(C(C)C)n2)NC(c3ccccc3)=O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":41526
  },
  {
    "COADD_ID":"CO-ADD:0217071",
    "INHIB_AVE":8.16,
    "SMILES":"c1(c(Br)cc(cc1Br)C=O)OC(=O)c2ccc(cc2)C",
    "HIT":0.0,
    "question":"Can c1(c(Br)cc(cc1Br)C=O)OC(=O)c2ccc(cc2)C effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":22604
  },
  {
    "COADD_ID":"CO-ADD:0229160",
    "INHIB_AVE":3.89,
    "SMILES":"c1(NC(=O)c(cc2OC)cc(c2OC)OC)sc(c3c1C(OCC)=O)CCCC3",
    "HIT":0.0,
    "question":"Does treatment with c1(NC(=O)c(cc2OC)cc(c2OC)OC)sc(c3c1C(OCC)=O)CCCC3 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":40653
  },
  {
    "COADD_ID":"CO-ADD:0136562",
    "INHIB_AVE":-12.4,
    "SMILES":"N(=Nc(c(O)ccc1N=Nc(cccc2)c2)c1O)c(cccc3)c3",
    "HIT":0.0,
    "question":"Does N(=Nc(c(O)ccc1N=Nc(cccc2)c2)c1O)c(cccc3)c3 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":80248
  },
  {
    "COADD_ID":"CO-ADD:0215277",
    "INHIB_AVE":6.44,
    "SMILES":"N1(c2ccccc2Cl)C(=O)C(C3C1=O)C(c4ccccc4)C=CC3c5ccccc5",
    "HIT":0.0,
    "question":"Does the proposed molecule N1(c2ccccc2Cl)C(=O)C(C3C1=O)C(c4ccccc4)C=CC3c5ccccc5 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":29366
  },
  {
    "COADD_ID":"CO-ADD:0279214",
    "INHIB_AVE":3.58,
    "SMILES":"N1(C2c3c(OC)ccc(cccc4)c34)C(S\\C(=C\\c(cc(n5c6ccc(cc6)Cl)C)c5C)\\C1=O)=NC(c7ccccc7)=C2C(OCC)=O",
    "HIT":0.0,
    "question":"Does the proposed molecule N1(C2c3c(OC)ccc(cccc4)c34)C(S\\C(=C\\c(cc(n5c6ccc(cc6)Cl)C)c5C)\\C1=O)=NC(c7ccccc7)=C2C(OCC)=O exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":42059
  },
  {
    "COADD_ID":"CO-ADD:0288017",
    "INHIB_AVE":1.89,
    "SMILES":"S1(=O)(=O)C(c2ccccc2)C(=O)Nc3c1cc(cc3[N+](=O)[O-])[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Can S1(=O)(=O)C(c2ccccc2)C(=O)Nc3c1cc(cc3[N+](=O)[O-])[N+](=O)[O-] act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":49610
  },
  {
    "COADD_ID":"CO-ADD:0249895",
    "INHIB_AVE":2.7,
    "SMILES":"c1(nnc(Cc(cc2)ccc2OC)s1)NC(=O)c(cc3)ccc3C(C)(C)C",
    "HIT":0.0,
    "question":"Can exposure to c1(nnc(Cc(cc2)ccc2OC)s1)NC(=O)c(cc3)ccc3C(C)(C)C lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":45980
  },
  {
    "COADD_ID":"CO-ADD:0215442",
    "INHIB_AVE":18.29,
    "SMILES":"C(Oc(cccc1C(=O)Nc(cc2)ccc2Cl)c1)(=S)Nc(cc3)ccc3I",
    "HIT":0.0,
    "question":"Can C(Oc(cccc1C(=O)Nc(cc2)ccc2Cl)c1)(=S)Nc(cc3)ccc3I effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":4070
  },
  {
    "COADD_ID":"CO-ADD:0292752",
    "INHIB_AVE":0.62,
    "SMILES":"n1(c2ccccc2)c(SCC(=O)Nc(ccc(c3s4)nc4SCC(=O)Nc5ccccc5)c3)nnc1c(cc6)ccc6C(C)(C)C",
    "HIT":0.0,
    "question":"Does n1(c2ccccc2)c(SCC(=O)Nc(ccc(c3s4)nc4SCC(=O)Nc5ccccc5)c3)nnc1c(cc6)ccc6C(C)(C)C demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":55027
  },
  {
    "COADD_ID":"CO-ADD:0231685",
    "INHIB_AVE":0.51,
    "SMILES":"[N+](=O)([O-])c1cc(ccc1Br)\\C=N\\c(cc2)ccc2I",
    "HIT":0.0,
    "question":"Does [N+](=O)([O-])c1cc(ccc1Br)\\C=N\\c(cc2)ccc2I demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":55463
  },
  {
    "COADD_ID":"CO-ADD:0307560",
    "INHIB_AVE":4.33,
    "SMILES":"c1(noc(c2ccc(Br)o2)n1)c3nonc3N",
    "HIT":0.0,
    "question":"Does treatment with c1(noc(c2ccc(Br)o2)n1)c3nonc3N result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":38690
  },
  {
    "COADD_ID":"CO-ADD:0228660",
    "INHIB_AVE":4.8,
    "SMILES":"c1(csc(Nc2ccccc2)n1)C3(C)CC(C(=O)O3)CC",
    "HIT":0.0,
    "question":"Is c1(csc(Nc2ccccc2)n1)C3(C)CC(C(=O)O3)CC capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":36568
  },
  {
    "COADD_ID":"CO-ADD:0257042",
    "INHIB_AVE":18.87,
    "SMILES":"n1(c2ccccc2)c(SCC(=O)c3ccc(cc3)CC)nnc1c4ccco4",
    "HIT":0.0,
    "question":"Does n1(c2ccccc2)c(SCC(=O)c3ccc(cc3)CC)nnc1c4ccco4 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":3606
  },
  {
    "COADD_ID":"CO-ADD:0220816",
    "INHIB_AVE":3.89,
    "SMILES":"c(Nc1ccccc1)(nc(N\\N=C\\c(cc2)ccc2I)nc3Nc(cc4)ccc4OC)n3",
    "HIT":0.0,
    "question":"Does c(Nc1ccccc1)(nc(N\\N=C\\c(cc2)ccc2I)nc3Nc(cc4)ccc4OC)n3 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":40675
  },
  {
    "COADD_ID":"CO-ADD:0240357",
    "INHIB_AVE":4.9,
    "SMILES":"[N+](=O)([O-])c1ccccc1C(=O)NN\\C(\\C)=C\\C(c2ccccc2)=O",
    "HIT":0.0,
    "question":"Does [N+](=O)([O-])c1ccccc1C(=O)NN\\C(\\C)=C\\C(c2ccccc2)=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":36089
  },
  {
    "COADD_ID":"CO-ADD:0329742",
    "INHIB_AVE":-3.53,
    "SMILES":"C1(C(F)(F)F)(NC(=O)c2ccccc2F)C(=O)NC3=C1C(=O)NC(N3c4ccccc4)=O",
    "HIT":0.0,
    "question":"Does C1(C(F)(F)F)(NC(=O)c2ccccc2F)C(=O)NC3=C1C(=O)NC(N3c4ccccc4)=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":68595
  },
  {
    "COADD_ID":"CO-ADD:0160279",
    "INHIB_AVE":13.72,
    "SMILES":"ClC1=C(OC)C=CC(\/C=N\/C2=CC=C(C=C2)C(O3)=NC4=C3C=C(C)C=C4)=C1",
    "HIT":0.0,
    "question":"Is ClC1=C(OC)C=CC(\/C=N\/C2=CC=C(C=C2)C(O3)=NC4=C3C=C(C)C=C4)=C1 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":9448
  },
  {
    "COADD_ID":"CO-ADD:0284914",
    "INHIB_AVE":-5.97,
    "SMILES":"n1c(SCC)c2c(c(C)n1)cccc2",
    "HIT":0.0,
    "question":"Is n1c(SCC)c2c(c(C)n1)cccc2 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":73681
  },
  {
    "COADD_ID":"CO-ADD:0226016",
    "INHIB_AVE":13.62,
    "SMILES":"C1(=N2)N(C=CN=C1N3CCCC(C)C3)C(N2CC(=O)Nc4ccc(cc4F)F)=O",
    "HIT":0.0,
    "question":"Does C1(=N2)N(C=CN=C1N3CCCC(C)C3)C(N2CC(=O)Nc4ccc(cc4F)F)=O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":9593
  },
  {
    "COADD_ID":"CO-ADD:0300474",
    "INHIB_AVE":12.32,
    "SMILES":"[nH]1c(SCCOc2ccccc2F)nc3c1ncnc3N",
    "HIT":0.0,
    "question":"Is [nH]1c(SCCOc2ccccc2F)nc3c1ncnc3N capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":11823
  },
  {
    "COADD_ID":"CO-ADD:0137181",
    "INHIB_AVE":-12.43,
    "SMILES":"c1(O)cc(OC(=O)c(c2c(o3)cc(O)cc2)c34)c4cc1",
    "HIT":0.0,
    "question":"Can c1(O)cc(OC(=O)c(c2c(o3)cc(O)cc2)c34)c4cc1 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":80264
  },
  {
    "COADD_ID":"CO-ADD:0232006",
    "INHIB_AVE":5.85,
    "SMILES":"[N+](=O)([O-])c(cc1\\C=N\\NC(c(cc2)ccn2)=O)cc(c1OC(=O)c3ccc(cc3)Br)Br",
    "HIT":0.0,
    "question":"Does [N+](=O)([O-])c(cc1\\C=N\\NC(c(cc2)ccn2)=O)cc(c1OC(=O)c3ccc(cc3)Br)Br demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":31855
  },
  {
    "COADD_ID":"CO-ADD:0231210",
    "INHIB_AVE":-4.68,
    "SMILES":"c1(O)c(cccc1\\C=N\\NC(CCCc(ccc(c2C)OC)c2)=O)OC",
    "HIT":0.0,
    "question":"Can exposure to c1(O)c(cccc1\\C=N\\NC(CCCc(ccc(c2C)OC)c2)=O)OC lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":71201
  },
  {
    "COADD_ID":"CO-ADD:0323977",
    "INHIB_AVE":9.23,
    "SMILES":"S(=O)(=O)(NC(CC1(C)C)CC(N1)(C)C)c2c(C)cc(c(OC)c2)C",
    "HIT":0.0,
    "question":"Does S(=O)(=O)(NC(CC1(C)C)CC(N1)(C)C)c2c(C)cc(c(OC)c2)C demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":19234
  },
  {
    "COADD_ID":"CO-ADD:0255911",
    "INHIB_AVE":-9.52,
    "SMILES":"S(=O)(=O)(c1ccc(cc1)C)N(Cc2ccccc2)c3ccccc3C(NCCSc4sc(c5n4)cccc5)=O",
    "HIT":0.0,
    "question":"Does the proposed molecule S(=O)(=O)(c1ccc(cc1)C)N(Cc2ccccc2)c3ccccc3C(NCCSc4sc(c5n4)cccc5)=O exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":78339
  },
  {
    "COADD_ID":"CO-ADD:0285220",
    "INHIB_AVE":-0.19,
    "SMILES":"N1(c2cccc(Cl)c2)C(=O)C(CC1=O)SCC(N)C(OCC)=O.Cl",
    "HIT":0.0,
    "question":"Does the proposed molecule N1(c2cccc(Cl)c2)C(=O)C(CC1=O)SCC(N)C(OCC)=O.Cl exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":58194
  },
  {
    "COADD_ID":"CO-ADD:0254720",
    "INHIB_AVE":2.64,
    "SMILES":"N1(C2c3ccc(c(OC)c3)OC)C(S\\C(=C\\c(ccc4c5ccccc5C(O)=O)o4)\\C1=O)=NC(C)=C2C(OCC)=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound N1(C2c3ccc(c(OC)c3)OC)C(S\\C(=C\\c(ccc4c5ccccc5C(O)=O)o4)\\C1=O)=NC(C)=C2C(OCC)=O?",
    "answer":"No",
    "_id":46222
  },
  {
    "COADD_ID":"CO-ADD:0320735",
    "INHIB_AVE":18.19,
    "SMILES":"N1(c2cccc(Cl)c2)C(c3ccc(c4c3)OCO4)C(C1=O)Oc5ccccc5",
    "HIT":0.0,
    "question":"Does treatment with N1(c2cccc(Cl)c2)C(c3ccc(c4c3)OCO4)C(C1=O)Oc5ccccc5 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":4146
  },
  {
    "COADD_ID":"CO-ADD:0328930",
    "INHIB_AVE":6.66,
    "SMILES":"n1(N)c(CC)nnc1N\\N=C\\c2c[nH]nc2c3ccc(cc3)F.Cl.Cl",
    "HIT":0.0,
    "question":"Is n1(N)c(CC)nnc1N\\N=C\\c2c[nH]nc2c3ccc(cc3)F.Cl.Cl capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":28469
  },
  {
    "COADD_ID":"CO-ADD:0301930",
    "INHIB_AVE":9.07,
    "SMILES":"c1(cc(ccc1N2CCCCC2)[N+](=O)[O-])C(=O)Nc(cc3)ccc3Oc4ccccc4",
    "HIT":0.0,
    "question":"Does c1(cc(ccc1N2CCCCC2)[N+](=O)[O-])C(=O)Nc(cc3)ccc3Oc4ccccc4 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":19659
  },
  {
    "COADD_ID":"CO-ADD:0254449",
    "INHIB_AVE":-33.21,
    "SMILES":"C12(C=Cc(c(c(OC)cc3[N+](=O)[O-])O1)c3)c4c(cccc4)c(c5N2C)cccc5",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C12(C=Cc(c(c(OC)cc3[N+](=O)[O-])O1)c3)c4c(cccc4)c(c5N2C)cccc5?",
    "answer":"No",
    "_id":82628
  },
  {
    "COADD_ID":"CO-ADD:0155451",
    "INHIB_AVE":-2.26,
    "SMILES":"O=C1NC(C(Br)=CC=C2)=C2\/C1=N\\NC(COC3=C(Br)C=C(C)C=C3Br)=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound O=C1NC(C(Br)=CC=C2)=C2\/C1=N\\NC(COC3=C(Br)C=C(C)C=C3Br)=O?",
    "answer":"No",
    "_id":65128
  },
  {
    "COADD_ID":"CO-ADD:0296007",
    "INHIB_AVE":-6.34,
    "SMILES":"C(=CC(\\C=C\\c(cc1)ccc1N2CCCC2)=NC3=O)(C(F)(F)F)N3",
    "HIT":0.0,
    "question":"Does the proposed molecule C(=CC(\\C=C\\c(cc1)ccc1N2CCCC2)=NC3=O)(C(F)(F)F)N3 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":74308
  },
  {
    "COADD_ID":"CO-ADD:0320218",
    "INHIB_AVE":-6.68,
    "SMILES":"C12=C(CCCC1=O)Nc(c3C2c4cccc(Cl)c4Cl)ccc5c3ccc(n5)C",
    "HIT":0.0,
    "question":"Is C12=C(CCCC1=O)Nc(c3C2c4cccc(Cl)c4Cl)ccc5c3ccc(n5)C capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":74858
  },
  {
    "COADD_ID":"CO-ADD:0300665",
    "INHIB_AVE":8.65,
    "SMILES":"C1(=COc(c2C1=O)ccc(Cl)c2)C3Nc4c(NC(CC(c5ccc(c(OC)c5)OC)CC6=O)=C36)cccc4",
    "HIT":0.0,
    "question":"Does the proposed molecule C1(=COc(c2C1=O)ccc(Cl)c2)C3Nc4c(NC(CC(c5ccc(c(OC)c5)OC)CC6=O)=C36)cccc4 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":21017
  },
  {
    "COADD_ID":"CO-ADD:0218193",
    "INHIB_AVE":0.39,
    "SMILES":"n1c(ccc(cccc2)c12)\\C=C\\c(cc3)ccc3\\C=C\\c4ccc(c5n4)cccc5",
    "HIT":0.0,
    "question":"Can exposure to n1c(ccc(cccc2)c12)\\C=C\\c(cc3)ccc3\\C=C\\c4ccc(c5n4)cccc5 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":55886
  },
  {
    "COADD_ID":"CO-ADD:0299557",
    "INHIB_AVE":1.84,
    "SMILES":"c1(cc(C#N)c(cc1Nc(cc2)ccc2Oc(cc3)ccc3Cl)C#N)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Is c1(cc(C#N)c(cc1Nc(cc2)ccc2Oc(cc3)ccc3Cl)C#N)[N+](=O)[O-] effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":49807
  },
  {
    "COADD_ID":"CO-ADD:0287423",
    "INHIB_AVE":-10.84,
    "SMILES":"C(C#N)(C1c2ccc(Br)s2)=C(N)N(C(CC(C)(C)CC3=O)=C13)c(cc4)ccc4S(N)(=O)=O",
    "HIT":0.0,
    "question":"Does C(C#N)(C1c2ccc(Br)s2)=C(N)N(C(CC(C)(C)CC3=O)=C13)c(cc4)ccc4S(N)(=O)=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":79307
  },
  {
    "COADD_ID":"CO-ADD:0243783",
    "INHIB_AVE":8.58,
    "SMILES":"c(c(SCC(=CC1=O)OC(C(c2cc3c(OCO3)c(OC)c2)CC(=O)OC)=C1O)c(F)c4)cc4F",
    "HIT":0.0,
    "question":"Does treatment with c(c(SCC(=CC1=O)OC(C(c2cc3c(OCO3)c(OC)c2)CC(=O)OC)=C1O)c(F)c4)cc4F result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":21224
  },
  {
    "COADD_ID":"CO-ADD:0241385",
    "INHIB_AVE":7.91,
    "SMILES":"c1(C(=O)OCC(=O)c2ccc(cc2)Cl)c(cccc1[N+](=O)[O-])C(=O)OCC(=O)c3ccc(cc3)Cl",
    "HIT":0.0,
    "question":"Does c1(C(=O)OCC(=O)c2ccc(cc2)Cl)c(cccc1[N+](=O)[O-])C(=O)OCC(=O)c3ccc(cc3)Cl demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":23537
  },
  {
    "COADD_ID":"CO-ADD:0255002",
    "INHIB_AVE":9.83,
    "SMILES":"C(C#N)(C1c(cc2)ccc2N(CC)CC)=C(N)N(C(CC(C)(C)CC3=O)=C13)c4ccc(cc4)C",
    "HIT":0.0,
    "question":"Does C(C#N)(C1c(cc2)ccc2N(CC)CC)=C(N)N(C(CC(C)(C)CC3=O)=C13)c4ccc(cc4)C show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":17499
  },
  {
    "COADD_ID":"CO-ADD:0283825",
    "INHIB_AVE":5.72,
    "SMILES":"S(=O)(=O)(c(ccc(c1C(=O)Nc2nnc(COc(cc3)ccc3Cl)s2)Cl)c1)N(CC4)CCO4",
    "HIT":0.0,
    "question":"Can exposure to S(=O)(=O)(c(ccc(c1C(=O)Nc2nnc(COc(cc3)ccc3Cl)s2)Cl)c1)N(CC4)CCO4 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":32434
  },
  {
    "COADD_ID":"CO-ADD:0292442",
    "INHIB_AVE":13.12,
    "SMILES":"c12c(C(N(C)C(=O)N1C)=O)n(c(N(C)C)n2)CC(c3ccccc3)=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c12c(C(N(C)C(=O)N1C)=O)n(c(N(C)C)n2)CC(c3ccccc3)=O?",
    "answer":"No",
    "_id":10368
  },
  {
    "COADD_ID":"CO-ADD:0304201",
    "INHIB_AVE":-0.02,
    "SMILES":"N1(c2ccc(cc2)OC)C(C)(CC)Nc(c3C1=O)cccc3",
    "HIT":0.0,
    "question":"Does treatment with N1(c2ccc(cc2)OC)C(C)(CC)Nc(c3C1=O)cccc3 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":57548
  },
  {
    "COADD_ID":"CO-ADD:0302409",
    "INHIB_AVE":6.77,
    "SMILES":"c1(cc(ccc1Cl)CNC(CCl)=O)C(O)=O",
    "HIT":0.0,
    "question":"Can exposure to c1(cc(ccc1Cl)CNC(CCl)=O)C(O)=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":27940
  },
  {
    "COADD_ID":"CO-ADD:0256400",
    "INHIB_AVE":-3.87,
    "SMILES":"N1(C(=O)c2c(c(cccc3)c3C1=O)cccc2)C4=CNC(NC4=O)=O",
    "HIT":0.0,
    "question":"Is N1(C(=O)c2c(c(cccc3)c3C1=O)cccc2)C4=CNC(NC4=O)=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":69450
  },
  {
    "COADD_ID":"CO-ADD:0256182",
    "INHIB_AVE":10.26,
    "SMILES":"N1(C2c(cc3)ccc3N(C)C)C(S\\C(=C\\c(cc4OC)cc(c4OC)I)\\C1=O)=NC(C)=C2C(OCC)=O",
    "HIT":0.0,
    "question":"Does N1(C2c(cc3)ccc3N(C)C)C(S\\C(=C\\c(cc4OC)cc(c4OC)I)\\C1=O)=NC(C)=C2C(OCC)=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":16327
  },
  {
    "COADD_ID":"CO-ADD:0256201",
    "INHIB_AVE":-9.77,
    "SMILES":"N1(c2ccc(c(Cl)c2)Cl)C(=O)C(=CC1=O)C",
    "HIT":0.0,
    "question":"Is N1(c2ccc(c(Cl)c2)Cl)C(=O)C(=CC1=O)C effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":78537
  },
  {
    "COADD_ID":"CO-ADD:0291157",
    "INHIB_AVE":4.52,
    "SMILES":"C(=O)(O\\N=C(\/c1ccc(cc1)Cl)\\NCc2ccccc2)c3cccs3",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C(=O)(O\\N=C(\/c1ccc(cc1)Cl)\\NCc2ccccc2)c3cccs3?",
    "answer":"No",
    "_id":37849
  },
  {
    "COADD_ID":"CO-ADD:0136917",
    "INHIB_AVE":15.7,
    "SMILES":"O1C(C(C(NC(c2ccccc2)=O)C(OC)O3)=O)C3COC1c4ccccc4",
    "HIT":0.0,
    "question":"Does O1C(C(C(NC(c2ccccc2)=O)C(OC)O3)=O)C3COC1c4ccccc4 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":6715
  },
  {
    "COADD_ID":"CO-ADD:0137034",
    "INHIB_AVE":-6.9,
    "SMILES":"N(C)(C(CC(OC(c1ccccc1)c2ccccc2)C3)CC4)C34.CS(O)(=O)=O",
    "HIT":0.0,
    "question":"Is N(C)(C(CC(OC(c1ccccc1)c2ccccc2)C3)CC4)C34.CS(O)(=O)=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":75182
  },
  {
    "COADD_ID":"CO-ADD:0329564",
    "INHIB_AVE":6.64,
    "SMILES":"C(=O)(c(cc1)ccc1C(C)(C)C)NC(c2ccc(cc2)OC)CC(OCC)=O",
    "HIT":0.0,
    "question":"Is C(=O)(c(cc1)ccc1C(C)(C)C)NC(c2ccc(cc2)OC)CC(OCC)=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":28553
  },
  {
    "COADD_ID":"CO-ADD:0155470",
    "INHIB_AVE":-7.51,
    "SMILES":"[O-][N+](C(C=CC=C1)=C1N(C2=CC=CC=C2)\/C=C3C(N(N=C\/3C)C(C=C4C)=CC=C4C)=O)=O",
    "HIT":0.0,
    "question":"Can [O-][N+](C(C=CC=C1)=C1N(C2=CC=CC=C2)\/C=C3C(N(N=C\/3C)C(C=C4C)=CC=C4C)=O)=O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":76077
  },
  {
    "COADD_ID":"CO-ADD:0304948",
    "INHIB_AVE":-3.26,
    "SMILES":"N1(c(ccc(c2s3)nc3SCC(NCCOc(cc4)ccc4Cl)=O)c2)C(=O)c(c5C1=O)ccc(c5)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Is N1(c(ccc(c2s3)nc3SCC(NCCOc(cc4)ccc4Cl)=O)c2)C(=O)c(c5C1=O)ccc(c5)[N+](=O)[O-] capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":67892
  },
  {
    "COADD_ID":"CO-ADD:0234442",
    "INHIB_AVE":1.43,
    "SMILES":"c1(C#N)c2c(sc1\\N=C\\c3ccc(I)s3)CC(C)CC2",
    "HIT":0.0,
    "question":"Does c1(C#N)c2c(sc1\\N=C\\c3ccc(I)s3)CC(C)CC2 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":51612
  },
  {
    "COADD_ID":"CO-ADD:0228495",
    "INHIB_AVE":4.81,
    "SMILES":"c1(C(OCC)=O)c2c(oc1CN(CC3)CCO3)ccc(OC)c2.Cl",
    "HIT":0.0,
    "question":"Does c1(C(OCC)=O)c2c(oc1CN(CC3)CCO3)ccc(OC)c2.Cl demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":36513
  },
  {
    "COADD_ID":"CO-ADD:0254908",
    "INHIB_AVE":-3.9,
    "SMILES":"c12c(non1)nc(Nc(ccc(c3N4)NC4=O)c3)c(N\\N=C\\c(ccc(c5OC)OCc6ccc(cc6Cl)Cl)c5)n2",
    "HIT":0.0,
    "question":"Does c12c(non1)nc(Nc(ccc(c3N4)NC4=O)c3)c(N\\N=C\\c(ccc(c5OC)OCc6ccc(cc6Cl)Cl)c5)n2 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":69514
  },
  {
    "COADD_ID":"CO-ADD:0284005",
    "INHIB_AVE":0.88,
    "SMILES":"C(C(OCC)=O)(C1c(cc2)ccn2)=C(C)NC(CC(c3ccc(cc3)OC)CC4=O)=C14",
    "HIT":0.0,
    "question":"Does C(C(OCC)=O)(C1c(cc2)ccn2)=C(C)NC(CC(c3ccc(cc3)OC)CC4=O)=C14 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":53966
  },
  {
    "COADD_ID":"CO-ADD:0236019",
    "INHIB_AVE":6.29,
    "SMILES":"C(=C\\c(cc1)cc(c1OC(C)=O)OC)(\/C(NCC=C)=O)\\NC(c2ccccc2)=O",
    "HIT":0.0,
    "question":"Can C(=C\\c(cc1)cc(c1OC(C)=O)OC)(\/C(NCC=C)=O)\\NC(c2ccccc2)=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":30047
  },
  {
    "COADD_ID":"CO-ADD:0149239",
    "INHIB_AVE":11.25,
    "SMILES":"s1cc(C(CC(=O)N2)c(snc3c4cccc(F)c4)c23)cc1",
    "HIT":0.0,
    "question":"Does s1cc(C(CC(=O)N2)c(snc3c4cccc(F)c4)c23)cc1 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":13986
  },
  {
    "COADD_ID":"CO-ADD:0332434",
    "INHIB_AVE":-1.2,
    "SMILES":"N1(Cc(cccc2)c2CC1C(=O)N3CCCCCC3)S(=O)(=O)c4ccc(cc4)OC",
    "HIT":0.0,
    "question":"Can exposure to N1(Cc(cccc2)c2CC1C(=O)N3CCCCCC3)S(=O)(=O)c4ccc(cc4)OC lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":61744
  },
  {
    "COADD_ID":"CO-ADD:0329245",
    "INHIB_AVE":14.75,
    "SMILES":"n(cccc1C)(cc(c2)c3ccc(cc3)Cl)c12",
    "HIT":0.0,
    "question":"Is n(cccc1C)(cc(c2)c3ccc(cc3)Cl)c12 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":7928
  },
  {
    "COADD_ID":"CO-ADD:0255708",
    "INHIB_AVE":0.96,
    "SMILES":"C1(=NCC(C)S1)N(Cc2ccccc2Cl)C(=O)Nc3cccc(Cl)c3",
    "HIT":0.0,
    "question":"Does C1(=NCC(C)S1)N(Cc2ccccc2Cl)C(=O)Nc3cccc(Cl)c3 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":53609
  },
  {
    "COADD_ID":"CO-ADD:0328802",
    "INHIB_AVE":10.23,
    "SMILES":"c12c(ccc(C(=O)NC3CCCCC3)c1NCCO)C(=O)c(c4C2=O)cccc4",
    "HIT":0.0,
    "question":"Can c12c(ccc(C(=O)NC3CCCCC3)c1NCCO)C(=O)c(c4C2=O)cccc4 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":16414
  },
  {
    "COADD_ID":"CO-ADD:0161151",
    "INHIB_AVE":-0.78,
    "SMILES":"c1(c(ccc(c2Cl)Cl)c2)ccc(\\C=N\\NC(COc3c(C)cccc3C)=O)o1",
    "HIT":0.0,
    "question":"Can c1(c(ccc(c2Cl)Cl)c2)ccc(\\C=N\\NC(COc3c(C)cccc3C)=O)o1 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":60357
  },
  {
    "COADD_ID":"CO-ADD:0310896",
    "INHIB_AVE":-3.31,
    "SMILES":"[N+](=O)([O-])c1ccc(cc1NCc2ccco2)N(CC3)CCN3",
    "HIT":0.0,
    "question":"Does treatment with [N+](=O)([O-])c1ccc(cc1NCc2ccco2)N(CC3)CCN3 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":68028
  },
  {
    "COADD_ID":"CO-ADD:0226969",
    "INHIB_AVE":18.96,
    "SMILES":"N1(c(ccs2)c2C(N3CCC(C)C)=O)C3=NN(CC(=O)NC(C)CC)C1=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound N1(c(ccs2)c2C(N3CCC(C)C)=O)C3=NN(CC(=O)NC(C)CC)C1=O?",
    "answer":"No",
    "_id":3543
  },
  {
    "COADD_ID":"CO-ADD:0257187",
    "INHIB_AVE":16.69,
    "SMILES":"C1(=CC=CNC1=O)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Does C1(=CC=CNC1=O)[N+](=O)[O-] show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":5589
  },
  {
    "COADD_ID":"CO-ADD:0278316",
    "INHIB_AVE":0.79,
    "SMILES":"c1(C(=O)OCc2ccc(cc2C)C)nonc1N",
    "HIT":0.0,
    "question":"Can c1(C(=O)OCc2ccc(cc2C)C)nonc1N act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":54362
  },
  {
    "COADD_ID":"CO-ADD:0258061",
    "INHIB_AVE":-0.3,
    "SMILES":"S(=O)(=O)(CCc(n1)oc(n1)c2ccccc2)c3ccc(cc3)C",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound S(=O)(=O)(CCc(n1)oc(n1)c2ccccc2)c3ccc(cc3)C?",
    "answer":"No",
    "_id":58598
  },
  {
    "COADD_ID":"CO-ADD:0232263",
    "INHIB_AVE":0.05,
    "SMILES":"N1\\C(=N\/N=C\/c2ccccc2O)\\S\\C(=C\\c(ccc3c4ccc(cc4Cl)[N+](=O)[O-])o3)\\C1=O",
    "HIT":0.0,
    "question":"Can N1\\C(=N\/N=C\/c2ccccc2O)\\S\\C(=C\\c(ccc3c4ccc(cc4Cl)[N+](=O)[O-])o3)\\C1=O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":57290
  },
  {
    "COADD_ID":"CO-ADD:0240238",
    "INHIB_AVE":20.46,
    "SMILES":"n(c(c1)c2ccc1C(=O)N(CC=C)c3ccccc3)c(c4ccccc4)c(n2)c5ccccc5",
    "HIT":0.0,
    "question":"Does n(c(c1)c2ccc1C(=O)N(CC=C)c3ccccc3)c(c4ccccc4)c(n2)c5ccccc5 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":2619
  },
  {
    "COADD_ID":"CO-ADD:0229971",
    "INHIB_AVE":10.7,
    "SMILES":"N(Cc1ccccc1)(Cc2ccccc2)C(CCC(=O)OCC(=O)c3ccc(cc3)Br)=O",
    "HIT":0.0,
    "question":"Can N(Cc1ccccc1)(Cc2ccccc2)C(CCC(=O)OCC(=O)c3ccc(cc3)Br)=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":15226
  },
  {
    "COADD_ID":"CO-ADD:0234276",
    "INHIB_AVE":6.29,
    "SMILES":"C(=N\\NC(CNC(=O)c1ccc(cc1)Cl)=O)(\/C2=O)\\c(cc(Br)cc3Br)c3N2",
    "HIT":0.0,
    "question":"Does C(=N\\NC(CNC(=O)c1ccc(cc1)Cl)=O)(\/C2=O)\\c(cc(Br)cc3Br)c3N2 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":30055
  },
  {
    "COADD_ID":"CO-ADD:0155654",
    "INHIB_AVE":-7.46,
    "SMILES":"O=C(C1=CC(Br)=CC=C21)N(C(C=C3)=CC=C3C(OCCCCCCCCCC)=O)C2=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound O=C(C1=CC(Br)=CC=C21)N(C(C=C3)=CC=C3C(OCCCCCCCCCC)=O)C2=O?",
    "answer":"No",
    "_id":76012
  },
  {
    "COADD_ID":"CO-ADD:0226688",
    "INHIB_AVE":0.41,
    "SMILES":"C1(=NN(C2=O)CC#N)N2c3c(ccc(c3)C(=O)NC4CCCC4)C(=O)N1Cc(cc5)ccc5C",
    "HIT":0.0,
    "question":"Does treatment with C1(=NN(C2=O)CC#N)N2c3c(ccc(c3)C(=O)NC4CCCC4)C(=O)N1Cc(cc5)ccc5C result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":55836
  },
  {
    "COADD_ID":"CO-ADD:0229146",
    "INHIB_AVE":-4.91,
    "SMILES":"C(=O)(c1cccc(C)c1)Nc(cc2)ccc2C(=O)N\\N=C\\c3ccccc3O",
    "HIT":0.0,
    "question":"Does treatment with C(=O)(c1cccc(C)c1)Nc(cc2)ccc2C(=O)N\\N=C\\c3ccccc3O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":71705
  },
  {
    "COADD_ID":"CO-ADD:0248099",
    "INHIB_AVE":-1.41,
    "SMILES":"N(C(=O)CC(N1)=O)=C1SCC(=O)Nc2ccccc2[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Can exposure to N(C(=O)CC(N1)=O)=C1SCC(=O)Nc2ccccc2[N+](=O)[O-] lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":62450
  },
  {
    "COADD_ID":"CO-ADD:0324213",
    "INHIB_AVE":-1.69,
    "SMILES":"C1(C(OCCSC)=O)=C(C)NC(=O)NC1c2ccc(cc2)OC(F)(F)F",
    "HIT":0.0,
    "question":"Is C1(C(OCCSC)=O)=C(C)NC(=O)NC1c2ccc(cc2)OC(F)(F)F effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":63385
  },
  {
    "COADD_ID":"CO-ADD:0241276",
    "INHIB_AVE":16.4,
    "SMILES":"C(=N\\c1ccccc1)(\/N(c2ccccc2)\\C(\\C3=O)=C\\c(ccc4c(cc5)cc(c5[N+](=O)[O-])C)o4)\\S3",
    "HIT":0.0,
    "question":"Is C(=N\\c1ccccc1)(\/N(c2ccccc2)\\C(\\C3=O)=C\\c(ccc4c(cc5)cc(c5[N+](=O)[O-])C)o4)\\S3 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":5906
  },
  {
    "COADD_ID":"CO-ADD:0294321",
    "INHIB_AVE":-6.33,
    "SMILES":"C(C(OC)=O)(C1c2cccs2)=C(C)N(C(C)=C1C(OC)=O)C",
    "HIT":0.0,
    "question":"Can C(C(OC)=O)(C1c2cccs2)=C(C)N(C(C)=C1C(OC)=O)C effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":74281
  },
  {
    "COADD_ID":"CO-ADD:0326801",
    "INHIB_AVE":7.09,
    "SMILES":"C1(=O)Nc2c(Oc(cc(cc3Oc4ccccc4Br)[N+](=O)[O-])c13)ccc(Cl)c2",
    "HIT":0.0,
    "question":"Does C1(=O)Nc2c(Oc(cc(cc3Oc4ccccc4Br)[N+](=O)[O-])c13)ccc(Cl)c2 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":26635
  },
  {
    "COADD_ID":"CO-ADD:0221097",
    "INHIB_AVE":6.39,
    "SMILES":"C(=O)(Nc1ccccc1)C(NCC=C)=S",
    "HIT":0.0,
    "question":"Can exposure to C(=O)(Nc1ccccc1)C(NCC=C)=S lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":29574
  },
  {
    "COADD_ID":"CO-ADD:0295559",
    "INHIB_AVE":14.09,
    "SMILES":"c1(cn[nH]c1C(NC)=O)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Does c1(cn[nH]c1C(NC)=O)[N+](=O)[O-] show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":8888
  },
  {
    "COADD_ID":"CO-ADD:0320171",
    "INHIB_AVE":17.91,
    "SMILES":"C(c1ccc(c2n1)cccc2)(C(C#N)c3c(N4C)cccc3)=C4",
    "HIT":0.0,
    "question":"Does C(c1ccc(c2n1)cccc2)(C(C#N)c3c(N4C)cccc3)=C4 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":4377
  },
  {
    "COADD_ID":"CO-ADD:0157787",
    "INHIB_AVE":2.89,
    "SMILES":"O=C(C(O)C1=CC=CC=C1)N\/N=C\/C2=CC(Br)=C(Br)O2",
    "HIT":0.0,
    "question":"Can O=C(C(O)C1=CC=CC=C1)N\/N=C\/C2=CC(Br)=C(Br)O2 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":45156
  },
  {
    "COADD_ID":"CO-ADD:0286000",
    "INHIB_AVE":-2.79,
    "SMILES":"O=C(NN)C1=CC=NC=C1",
    "HIT":0.0,
    "question":"Does O=C(NN)C1=CC=NC=C1 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":66643
  },
  {
    "COADD_ID":"CO-ADD:0227881",
    "INHIB_AVE":15.17,
    "SMILES":"N1(CN(CC)c2ccccc2)C(=O)c3c(cccc3)C1=O",
    "HIT":0.0,
    "question":"Is N1(CN(CC)c2ccccc2)C(=O)c3c(cccc3)C1=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":7387
  },
  {
    "COADD_ID":"CO-ADD:0285753",
    "INHIB_AVE":2.56,
    "SMILES":"C(O)(=O)C(CCCCCCCCCC(N)=O)Cc1ccccc1",
    "HIT":0.0,
    "question":"Can C(O)(=O)C(CCCCCCCCCC(N)=O)Cc1ccccc1 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":46601
  },
  {
    "COADD_ID":"CO-ADD:0321306",
    "INHIB_AVE":7.08,
    "SMILES":"N12C(SC(C(C)C)=N1)=NC(=O)\\C(=C\/c(ccc(c3OC)OCCOc4cccc(C)c4)c3)\\C2=N",
    "HIT":0.0,
    "question":"Does N12C(SC(C(C)C)=N1)=NC(=O)\\C(=C\/c(ccc(c3OC)OCCOc4cccc(C)c4)c3)\\C2=N demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":26661
  },
  {
    "COADD_ID":"CO-ADD:0292582",
    "INHIB_AVE":-10.37,
    "SMILES":"[N+](=O)([O-])c(c(C)c1)cc(c1N(CC2)CCN2C(=O)c3ccc(cc3)Br)F",
    "HIT":0.0,
    "question":"Does [N+](=O)([O-])c(c(C)c1)cc(c1N(CC2)CCN2C(=O)c3ccc(cc3)Br)F show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":78966
  },
  {
    "COADD_ID":"CO-ADD:0287342",
    "INHIB_AVE":-4.45,
    "SMILES":"C(N(C1CCCCC1)C(C)=O)(C(=O)c(cccc2)c2C3=O)=C3N4CCCCCC4",
    "HIT":0.0,
    "question":"Does the proposed molecule C(N(C1CCCCC1)C(C)=O)(C(=O)c(cccc2)c2C3=O)=C3N4CCCCCC4 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":70739
  },
  {
    "COADD_ID":"CO-ADD:0217767",
    "INHIB_AVE":8.11,
    "SMILES":"S(=O)(=O)(c1ccc(cc1)C)Nc(c2)cc3c(cccc3)n2",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound S(=O)(=O)(c1ccc(cc1)C)Nc(c2)cc3c(cccc3)n2?",
    "answer":"No",
    "_id":22807
  },
  {
    "COADD_ID":"CO-ADD:0295751",
    "INHIB_AVE":4.51,
    "SMILES":"c(CNC(=O)c1cccc(Br)c1)(c2C)c(C)n(n2)C",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c(CNC(=O)c1cccc(Br)c1)(c2C)c(C)n(n2)C?",
    "answer":"No",
    "_id":37873
  },
  {
    "COADD_ID":"CO-ADD:0237035",
    "INHIB_AVE":10.03,
    "SMILES":"NC(C=C1)=NC(N1C(O2)C(C(C2COP(OCCCNC(C(O)C(C)(C)CO)=O)(O)=O)O)O)=O",
    "HIT":0.0,
    "question":"Can exposure to NC(C=C1)=NC(N1C(O2)C(C(C2COP(OCCCNC(C(O)C(C)(C)CO)=O)(O)=O)O)O)=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":16906
  },
  {
    "COADD_ID":"CO-ADD:0331621",
    "INHIB_AVE":-3.56,
    "SMILES":"S(=O)(=O)(c1ccc(cc1)OCCC)NCC(C2)(CC(CC23)CC4C3)C4",
    "HIT":0.0,
    "question":"Is S(=O)(=O)(c1ccc(cc1)OCCC)NCC(C2)(CC(CC23)CC4C3)C4 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":68681
  },
  {
    "COADD_ID":"CO-ADD:0249908",
    "INHIB_AVE":18.81,
    "SMILES":"C1(Nc(c(Nc(cc2)ccc2I)nc3c4non3)n4)=C(C)N(N(c5ccccc5)C1=O)C",
    "HIT":0.0,
    "question":"Does C1(Nc(c(Nc(cc2)ccc2I)nc3c4non3)n4)=C(C)N(N(c5ccccc5)C1=O)C demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":3671
  },
  {
    "COADD_ID":"CO-ADD:0299761",
    "INHIB_AVE":13.96,
    "SMILES":"[N+](=O)([O-])c(ccc(c1O2)OC23CCCC3)c1",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound [N+](=O)([O-])c(ccc(c1O2)OC23CCCC3)c1?",
    "answer":"No",
    "_id":9088
  },
  {
    "COADD_ID":"CO-ADD:0294934",
    "INHIB_AVE":-18.08,
    "SMILES":"n1c2c(oc1c3ccc(cc3)NC(=O)c4cccc(OCCCC)c4)ccc(Cl)c2",
    "HIT":0.0,
    "question":"Is n1c2c(oc1c3ccc(cc3)NC(=O)c4cccc(OCCCC)c4)ccc(Cl)c2 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":81924
  },
  {
    "COADD_ID":"CO-ADD:0221375",
    "INHIB_AVE":18.76,
    "SMILES":"n(CC(OCC)=O)(c(cccc1)c1c2Sc3ccccc3)c2C",
    "HIT":0.0,
    "question":"Can n(CC(OCC)=O)(c(cccc1)c1c2Sc3ccccc3)c2C act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":3704
  },
  {
    "COADD_ID":"CO-ADD:0293521",
    "INHIB_AVE":1.84,
    "SMILES":"c(CNC(=O)c1ccc(Br)o1)(cn(n2)C)c2C",
    "HIT":0.0,
    "question":"Is c(CNC(=O)c1ccc(Br)o1)(cn(n2)C)c2C capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":49817
  },
  {
    "COADD_ID":"CO-ADD:0233331",
    "INHIB_AVE":10.22,
    "SMILES":"N1C(=O)NC(c2ccc(cc2)OC(C)C)C1=O",
    "HIT":0.0,
    "question":"Does the proposed molecule N1C(=O)NC(c2ccc(cc2)OC(C)C)C1=O exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":16460
  },
  {
    "COADD_ID":"CO-ADD:0242266",
    "INHIB_AVE":1.46,
    "SMILES":"c1(N2CCC(CC2)Cc3ccccc3)nc(N\\N=C\\c(ccc(c4[N+](=O)[O-])N(C)C)c4)nc(Nc(cc5)ccc5C)n1.Cl",
    "HIT":0.0,
    "question":"Does the proposed molecule c1(N2CCC(CC2)Cc3ccccc3)nc(N\\N=C\\c(ccc(c4[N+](=O)[O-])N(C)C)c4)nc(Nc(cc5)ccc5C)n1.Cl exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":51444
  },
  {
    "COADD_ID":"CO-ADD:0244669",
    "INHIB_AVE":-3.81,
    "SMILES":"S(=O)(=O)(c1ccc(cc1)C#N)Nc2ccccc2C",
    "HIT":0.0,
    "question":"Is S(=O)(=O)(c1ccc(cc1)C#N)Nc2ccccc2C capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":69315
  },
  {
    "COADD_ID":"CO-ADD:0312340",
    "INHIB_AVE":3.24,
    "SMILES":"c1(SCC(OC)=O)cc(ccc1C#N)SCC(OC)=O",
    "HIT":0.0,
    "question":"Can c1(SCC(OC)=O)cc(ccc1C#N)SCC(OC)=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":43554
  },
  {
    "COADD_ID":"CO-ADD:0305512",
    "INHIB_AVE":33.05,
    "SMILES":"[N+](=O)([O-])c1ccc(cc1NCc2ccco2)N3CCCC3",
    "HIT":0.0,
    "question":"Can exposure to [N+](=O)([O-])c1ccc(cc1NCc2ccco2)N3CCCC3 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":670
  },
  {
    "COADD_ID":"CO-ADD:0258817",
    "INHIB_AVE":7.28,
    "SMILES":"c(\\C=N\\Nc1ccc(cc1[N+](=O)[O-])[N+](=O)[O-])(cn(n2)Cc3ccc(cc3Cl)Cl)c2c4ccccc4",
    "HIT":0.0,
    "question":"Is c(\\C=N\\Nc1ccc(cc1[N+](=O)[O-])[N+](=O)[O-])(cn(n2)Cc3ccc(cc3Cl)Cl)c2c4ccccc4 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":25931
  },
  {
    "COADD_ID":"CO-ADD:0327802",
    "INHIB_AVE":-12.14,
    "SMILES":"c1(O)cc(Oc(cc(O)c(C\\C=C(\/C)\\C)c2O)c2C3=O)c3c(C\\C=C(\/C)\\C)c1O",
    "HIT":0.0,
    "question":"Can c1(O)cc(Oc(cc(O)c(C\\C=C(\/C)\\C)c2O)c2C3=O)c3c(C\\C=C(\/C)\\C)c1O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":80106
  },
  {
    "COADD_ID":"CO-ADD:0285596",
    "INHIB_AVE":5.53,
    "SMILES":"C1(C(=O)Nc(cc2)ccc2OCC)C3C1\\C=C\/CCCC3",
    "HIT":0.0,
    "question":"Is C1(C(=O)Nc(cc2)ccc2OCC)C3C1\\C=C\/CCCC3 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":33289
  },
  {
    "COADD_ID":"CO-ADD:0285660",
    "INHIB_AVE":-0.27,
    "SMILES":"N1C(c2ccccc2)CC(C(CCCCCCC)C1c3ccccc3)=O.CC(=O)O",
    "HIT":0.0,
    "question":"Does N1C(c2ccccc2)CC(C(CCCCCCC)C1c3ccccc3)=O.CC(=O)O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":58520
  },
  {
    "COADD_ID":"CO-ADD:0236403",
    "INHIB_AVE":15.12,
    "SMILES":"c1(ccc(Br)o1)C(=O)Oc(cc2)ccc2C(C)(C)c3ccc(cc3)OC(=O)c4ccc(Br)o4",
    "HIT":0.0,
    "question":"Does the proposed molecule c1(ccc(Br)o1)C(=O)Oc(cc2)ccc2C(C)(C)c3ccc(cc3)OC(=O)c4ccc(Br)o4 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":7441
  },
  {
    "COADD_ID":"CO-ADD:0234460",
    "INHIB_AVE":10.23,
    "SMILES":"N(c1cccc(OC)c1)(C(=O)C(C23)NN=C2C(OCC)=O)C3=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound N(c1cccc(OC)c1)(C(=O)C(C23)NN=C2C(OCC)=O)C3=O?",
    "answer":"No",
    "_id":16405
  },
  {
    "COADD_ID":"CO-ADD:0320948",
    "INHIB_AVE":6.71,
    "SMILES":"S(=O)(=O)(c1ccc(cc1)Cl)c2c(C)c(SCC(OC)=O)cc(c2)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Can S(=O)(=O)(c1ccc(cc1)Cl)c2c(C)c(SCC(OC)=O)cc(c2)[N+](=O)[O-] effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":28241
  },
  {
    "COADD_ID":"CO-ADD:0157837",
    "INHIB_AVE":3.67,
    "SMILES":"O=C1\/C(N=C(C(C=C2)=CC=C2I)O1)=C\/C3=CC=C(C)O3",
    "HIT":0.0,
    "question":"Can O=C1\/C(N=C(C(C=C2)=CC=C2I)O1)=C\/C3=CC=C(C)O3 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":41627
  },
  {
    "COADD_ID":"CO-ADD:0296097",
    "INHIB_AVE":1.79,
    "SMILES":"C(=O)(NC(C)(C(C)C)C#N)c1cccnc1Oc(cc2)ccc2Cl",
    "HIT":0.0,
    "question":"Can C(=O)(NC(C)(C(C)C)C#N)c1cccnc1Oc(cc2)ccc2Cl act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":50025
  },
  {
    "COADD_ID":"CO-ADD:0283840",
    "INHIB_AVE":-3.89,
    "SMILES":"C(=O)(N\\N=C(\\CC)\/CC)C(=O)Nc1ccc(cc1C)Cl",
    "HIT":0.0,
    "question":"Does C(=O)(N\\N=C(\\CC)\/CC)C(=O)Nc1ccc(cc1C)Cl demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":69478
  },
  {
    "COADD_ID":"CO-ADD:0278129",
    "INHIB_AVE":16.48,
    "SMILES":"s1c(c(cc2)ccc2C(C)(C)C)nnc1NC(=O)c(cccc3[N+](=O)[O-])c3",
    "HIT":0.0,
    "question":"Does s1c(c(cc2)ccc2C(C)(C)C)nnc1NC(=O)c(cccc3[N+](=O)[O-])c3 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":5837
  },
  {
    "COADD_ID":"CO-ADD:0241842",
    "INHIB_AVE":20.11,
    "SMILES":"c1(N(CC)CC)nc(N\\N=C\\c(cc(Br)cc2Br)c2OC)nc(Nc(ccc(c3Cl)C)c3)n1.Cl",
    "HIT":0.0,
    "question":"Is c1(N(CC)CC)nc(N\\N=C\\c(cc(Br)cc2Br)c2OC)nc(Nc(ccc(c3Cl)C)c3)n1.Cl effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":2818
  },
  {
    "COADD_ID":"CO-ADD:0324479",
    "INHIB_AVE":-1.71,
    "SMILES":"C1(=O)Nc(ccc(c2)C)c2Oc(cc(cc3Oc4ccccc4)[N+](=O)[O-])c13",
    "HIT":0.0,
    "question":"Is C1(=O)Nc(ccc(c2)C)c2Oc(cc(cc3Oc4ccccc4)[N+](=O)[O-])c13 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":63430
  },
  {
    "COADD_ID":"CO-ADD:0320915",
    "INHIB_AVE":9.15,
    "SMILES":"C(=C\\C(=O)c1ccc(cc1)OC)(\/C2=O)\\Nc(c(ccc3S(CC)(=O)=O)O2)c3",
    "HIT":0.0,
    "question":"Does C(=C\\C(=O)c1ccc(cc1)OC)(\/C2=O)\\Nc(c(ccc3S(CC)(=O)=O)O2)c3 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":19460
  },
  {
    "COADD_ID":"CO-ADD:0329190",
    "INHIB_AVE":11.97,
    "SMILES":"n1c(c2ccc(cc2)Cl)onc1c3ccc(Br)o3",
    "HIT":0.0,
    "question":"Does n1c(c2ccc(cc2)Cl)onc1c3ccc(Br)o3 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":12494
  },
  {
    "COADD_ID":"CO-ADD:0320267",
    "INHIB_AVE":6.73,
    "SMILES":"c1(C#N)c(C)c(Cl)c(nc1SCc(cc2)ccc2[N+](=O)[O-])C",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(C#N)c(C)c(Cl)c(nc1SCc(cc2)ccc2[N+](=O)[O-])C?",
    "answer":"No",
    "_id":28156
  },
  {
    "COADD_ID":"CO-ADD:0312144",
    "INHIB_AVE":29.65,
    "SMILES":"c12c(nnc(SCC(=O)N3CCCCC3)n1)c(c4n2C(C)C)cccc4",
    "HIT":0.0,
    "question":"Is c12c(nnc(SCC(=O)N3CCCCC3)n1)c(c4n2C(C)C)cccc4 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":790
  },
  {
    "COADD_ID":"CO-ADD:0154403",
    "INHIB_AVE":11.46,
    "SMILES":"O=C(N\/N=C\/CC1=CC=CC=C1)C2=CC3=CC=CC=C3N2",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound O=C(N\/N=C\/CC1=CC=CC=C1)C2=CC3=CC=CC=C3N2?",
    "answer":"No",
    "_id":13534
  },
  {
    "COADD_ID":"CO-ADD:0285177",
    "INHIB_AVE":6.0,
    "SMILES":"N1(Cc2cccc(cccc3)c23)c(cccc4)c4\\C(=N\\NC(=O)c5cccc(Cl)c5)\\C1=O",
    "HIT":0.0,
    "question":"Can N1(Cc2cccc(cccc3)c23)c(cccc4)c4\\C(=N\\NC(=O)c5cccc(Cl)c5)\\C1=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":31267
  },
  {
    "COADD_ID":"CO-ADD:0218332",
    "INHIB_AVE":1.71,
    "SMILES":"c1(ccccc1O)C(=O)N\\N=C\\c(cc2)ccc2N(CC)CC",
    "HIT":0.0,
    "question":"Does c1(ccccc1O)C(=O)N\\N=C\\c(cc2)ccc2N(CC)CC demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":50417
  },
  {
    "COADD_ID":"CO-ADD:0321253",
    "INHIB_AVE":-3.33,
    "SMILES":"c1(N=P(c2ccccc2)(c3ccccc3)c4ccccc4)c(c(COC)cc(n5)C)c5sc1C(OCC)=O",
    "HIT":0.0,
    "question":"Is c1(N=P(c2ccccc2)(c3ccccc3)c4ccccc4)c(c(COC)cc(n5)C)c5sc1C(OCC)=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":68089
  },
  {
    "COADD_ID":"CO-ADD:0244582",
    "INHIB_AVE":16.32,
    "SMILES":"N1(c2ccccc2C)C(=O)c(c3C1=O)ccc(C(=O)c(ccc(c4C5=O)C(N5c6ccccc6C)=O)c4)c3",
    "HIT":0.0,
    "question":"Does treatment with N1(c2ccccc2C)C(=O)c(c3C1=O)ccc(C(=O)c(ccc(c4C5=O)C(N5c6ccccc6C)=O)c4)c3 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":5999
  },
  {
    "COADD_ID":"CO-ADD:0247714",
    "INHIB_AVE":-25.58,
    "SMILES":"C(C(O)=O)(C(c1ccc(cc1)Br)C2C(O)=O)=C(C(C#N)C#N)NC2(C)O.n3ccccc3",
    "HIT":0.0,
    "question":"Does C(C(O)=O)(C(c1ccc(cc1)Br)C2C(O)=O)=C(C(C#N)C#N)NC2(C)O.n3ccccc3 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":82477
  },
  {
    "COADD_ID":"CO-ADD:0223568",
    "INHIB_AVE":7.55,
    "SMILES":"S(=O)(=O)(c1ccc(cc1)NC(C)=O)NC(NC(COc2ccc(cc2Cl)Cl)=O)C(Cl)(Cl)Cl",
    "HIT":0.0,
    "question":"Is S(=O)(=O)(c1ccc(cc1)NC(C)=O)NC(NC(COc2ccc(cc2Cl)Cl)=O)C(Cl)(Cl)Cl effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":24873
  },
  {
    "COADD_ID":"CO-ADD:0228458",
    "INHIB_AVE":-8.01,
    "SMILES":"N(c1cc(C)ccc1C)(C(=O)C(C2C3(Br)c4c5cccc4)C5(Br)c(c36)cccc6)C2=O",
    "HIT":0.0,
    "question":"Can exposure to N(c1cc(C)ccc1C)(C(=O)C(C2C3(Br)c4c5cccc4)C5(Br)c(c36)cccc6)C2=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":76730
  },
  {
    "COADD_ID":"CO-ADD:0233323",
    "INHIB_AVE":22.13,
    "SMILES":"C(C)(N)(c1ccc(cc1)OCCC)C(O)=O.Cl",
    "HIT":0.0,
    "question":"Can C(C)(N)(c1ccc(cc1)OCCC)C(O)=O.Cl effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":1909
  },
  {
    "COADD_ID":"CO-ADD:0240656",
    "INHIB_AVE":22.89,
    "SMILES":"n1(nnc(C(OCC)=O)c1CN(CC2)CCN2CCO)c3nonc3N",
    "HIT":0.0,
    "question":"Does n1(nnc(C(OCC)=O)c1CN(CC2)CCN2CCO)c3nonc3N demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":1654
  },
  {
    "COADD_ID":"CO-ADD:0135716",
    "INHIB_AVE":-6.94,
    "SMILES":"O=C1N([H])c2n(ncn2)C(N)=C1",
    "HIT":0.0,
    "question":"Does the proposed molecule O=C1N([H])c2n(ncn2)C(N)=C1 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":75232
  },
  {
    "COADD_ID":"CO-ADD:0161978",
    "INHIB_AVE":7.99,
    "SMILES":"c1(ccccc1NC(c2ccccc2)=O)C(=O)N\\N=C\\c3cccc(cccc4)c34",
    "HIT":0.0,
    "question":"Is c1(ccccc1NC(c2ccccc2)=O)C(=O)N\\N=C\\c3cccc(cccc4)c34 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":23216
  },
  {
    "COADD_ID":"CO-ADD:0299852",
    "INHIB_AVE":5.55,
    "SMILES":"N1(c2cccc(OC)c2)C(=O)NC(\\C(=C\/c3ccc(cc3OC)OC)\\C1=O)=O",
    "HIT":0.0,
    "question":"Does treatment with N1(c2cccc(OC)c2)C(=O)NC(\\C(=C\/c3ccc(cc3OC)OC)\\C1=O)=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":33187
  },
  {
    "COADD_ID":"CO-ADD:0319458",
    "INHIB_AVE":-1.78,
    "SMILES":"C1(=O)N(c2ccc(cc2)Cl)C(C)=CC(C)=C1C(O)=O",
    "HIT":0.0,
    "question":"Does treatment with C1(=O)N(c2ccc(cc2)Cl)C(C)=CC(C)=C1C(O)=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":63663
  },
  {
    "COADD_ID":"CO-ADD:0220934",
    "INHIB_AVE":11.87,
    "SMILES":"C(=N\/NC(=O)c1ccccc1Cl)(\/C2=O)\\c(c3)c(N2)c(cc3[N+](=O)[O-])C",
    "HIT":0.0,
    "question":"Is C(=N\/NC(=O)c1ccccc1Cl)(\/C2=O)\\c(c3)c(N2)c(cc3[N+](=O)[O-])C effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":12690
  },
  {
    "COADD_ID":"CO-ADD:0323334",
    "INHIB_AVE":9.1,
    "SMILES":"c1(C(=O)N(C)C(N2C)=O)c2nc3n1cc(n3c4ccc(cc4)OC(F)(F)F)c5ccc(cc5)Br",
    "HIT":0.0,
    "question":"Can exposure to c1(C(=O)N(C)C(N2C)=O)c2nc3n1cc(n3c4ccc(cc4)OC(F)(F)F)c5ccc(cc5)Br lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":19565
  },
  {
    "COADD_ID":"CO-ADD:0278787",
    "INHIB_AVE":2.49,
    "SMILES":"n1(c(ccc(c2C)C)c2n3)c3S\\C(=C\/c(cc4OC)cc(c4O)Cl)\\C1=O",
    "HIT":0.0,
    "question":"Is n1(c(ccc(c2C)C)c2n3)c3S\\C(=C\/c(cc4OC)cc(c4O)Cl)\\C1=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":46922
  },
  {
    "COADD_ID":"CO-ADD:0162559",
    "INHIB_AVE":8.03,
    "SMILES":"N1(c2ccc(cc2)OC(C)=O)C(=O)CC(N(CC3)CCN3c4ccccc4)C1=O",
    "HIT":0.0,
    "question":"Does treatment with N1(c2ccc(cc2)OC(C)=O)C(=O)CC(N(CC3)CCN3c4ccccc4)C1=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":23070
  },
  {
    "COADD_ID":"CO-ADD:0230756",
    "INHIB_AVE":-8.08,
    "SMILES":"C(F)(F)(C(F)F)Oc1ccccc1NC(=O)C(=O)N\\N=C\\c(cc2)ccc2OCc3ccccc3",
    "HIT":0.0,
    "question":"Does the proposed molecule C(F)(F)(C(F)F)Oc1ccccc1NC(=O)C(=O)N\\N=C\\c(cc2)ccc2OCc3ccccc3 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":76819
  },
  {
    "COADD_ID":"CO-ADD:0236705",
    "INHIB_AVE":11.69,
    "SMILES":"c1(C(=O)N\\N=C\\c2cccc(cccc3)c23)c(C)nc(cc(C)cc4)n14",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(C(=O)N\\N=C\\c2cccc(cccc3)c23)c(C)nc(cc(C)cc4)n14?",
    "answer":"No",
    "_id":13061
  },
  {
    "COADD_ID":"CO-ADD:0219802",
    "INHIB_AVE":6.41,
    "SMILES":"C(OCCCC)(=O)c1ccc(cc1)\\N=C\\c(cc2)ccc2OCc3ccccc3",
    "HIT":0.0,
    "question":"Can C(OCCCC)(=O)c1ccc(cc1)\\N=C\\c(cc2)ccc2OCc3ccccc3 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":29483
  },
  {
    "COADD_ID":"CO-ADD:0255335",
    "INHIB_AVE":2.67,
    "SMILES":"c(sc(c1C(F)(F)F)c2ccc(cc2)Cl)(N(c3ccc(cc3C)C)C(=O)c4cccc(OC)c4)n1",
    "HIT":0.0,
    "question":"Can c(sc(c1C(F)(F)F)c2ccc(cc2)Cl)(N(c3ccc(cc3C)C)C(=O)c4cccc(OC)c4)n1 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":46083
  },
  {
    "COADD_ID":"CO-ADD:0157115",
    "INHIB_AVE":8.83,
    "SMILES":"[O-][N+](C1=C(O)C(\/C=N\\C2=CC(C3=NC(C=C4C)=C(C=C4)O3)=C(O)C=C2)=CC=C1)=O",
    "HIT":0.0,
    "question":"Can exposure to [O-][N+](C1=C(O)C(\/C=N\\C2=CC(C3=NC(C=C4C)=C(C=C4)O3)=C(O)C=C2)=CC=C1)=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":20449
  },
  {
    "COADD_ID":"CO-ADD:0244179",
    "INHIB_AVE":6.1,
    "SMILES":"c1(C(OCC)=O)c(cc(OC(C)=O)c(c2)Br)c2n(C)c1CNc3ccccc3C(N)=O",
    "HIT":0.0,
    "question":"Does c1(C(OCC)=O)c(cc(OC(C)=O)c(c2)Br)c2n(C)c1CNc3ccccc3C(N)=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":30849
  },
  {
    "COADD_ID":"CO-ADD:0136102",
    "INHIB_AVE":8.94,
    "SMILES":"c1ccc(cc(c2cncnc2N)cc3)c3c1",
    "HIT":0.0,
    "question":"Can exposure to c1ccc(cc(c2cncnc2N)cc3)c3c1 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":20084
  },
  {
    "COADD_ID":"CO-ADD:0324620",
    "INHIB_AVE":9.16,
    "SMILES":"C(C(C)=O)(C1c2cccc(F)c2)=C(O)C(N1c3ccc(cc3)OCC(O)=O)=O",
    "HIT":0.0,
    "question":"Does treatment with C(C(C)=O)(C1c2cccc(F)c2)=C(O)C(N1c3ccc(cc3)OCC(O)=O)=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":19426
  },
  {
    "COADD_ID":"CO-ADD:0331908",
    "INHIB_AVE":0.73,
    "SMILES":"S(=O)(=O)(N(CC1)CCN1c2ccc(c(Cl)c2)Cl)c3cc(C)ccc3OC",
    "HIT":0.0,
    "question":"Can exposure to S(=O)(=O)(N(CC1)CCN1c2ccc(c(Cl)c2)Cl)c3cc(C)ccc3OC lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":54585
  },
  {
    "COADD_ID":"CO-ADD:0233595",
    "INHIB_AVE":1.4,
    "SMILES":"[N+](=O)([O-])c1cccc(c1)\\C=N\\NC(c(cc2)ccn2)=O",
    "HIT":0.0,
    "question":"Can [N+](=O)([O-])c1cccc(c1)\\C=N\\NC(c(cc2)ccn2)=O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":51730
  },
  {
    "COADD_ID":"CO-ADD:0223560",
    "INHIB_AVE":10.52,
    "SMILES":"c1(C(OCC)=O)c(cc(OC)cc2)c2n(C)c1C",
    "HIT":0.0,
    "question":"Can c1(C(OCC)=O)c(cc(OC)cc2)c2n(C)c1C effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":15694
  },
  {
    "COADD_ID":"CO-ADD:0301166",
    "INHIB_AVE":8.6,
    "SMILES":"C1(CC2c3ccccc3Cl)(CC(C)(C)NC(=S)N1)Oc4c2cc(c(OC(C)=O)c4)Cl",
    "HIT":0.0,
    "question":"Is C1(CC2c3ccccc3Cl)(CC(C)(C)NC(=S)N1)Oc4c2cc(c(OC(C)=O)c4)Cl effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":21151
  },
  {
    "COADD_ID":"CO-ADD:0163169",
    "INHIB_AVE":8.03,
    "SMILES":"c1(CSCC(=O)Nc(ccc(c23)cccc2)c3)c(C)ccc(cccc4)c14",
    "HIT":0.0,
    "question":"Does treatment with c1(CSCC(=O)Nc(ccc(c23)cccc2)c3)c(C)ccc(cccc4)c14 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":23087
  },
  {
    "COADD_ID":"CO-ADD:0255644",
    "INHIB_AVE":-8.95,
    "SMILES":"c1(SCC(=O)Nc2ccccc2F)sc3c(ccc(c3)NC(=O)c4ccccc4OC)n1",
    "HIT":0.0,
    "question":"Can c1(SCC(=O)Nc2ccccc2F)sc3c(ccc(c3)NC(=O)c4ccccc4OC)n1 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":77810
  },
  {
    "COADD_ID":"CO-ADD:0256018",
    "INHIB_AVE":1.28,
    "SMILES":"c1(SCC(=O)c2ccc(cc2)Br)sc3c(ccc(c3)\\N=C\\c4ccc(cc4Cl)Cl)n1",
    "HIT":0.0,
    "question":"Can c1(SCC(=O)c2ccc(cc2)Br)sc3c(ccc(c3)\\N=C\\c4ccc(cc4Cl)Cl)n1 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":52258
  },
  {
    "COADD_ID":"CO-ADD:0284420",
    "INHIB_AVE":-9.62,
    "SMILES":"c1(C#N)c2c(sc1\\N=C\\c(ccc(c3[N+](=O)[O-])N4CCC(CC4)C)c3)CCCC2",
    "HIT":0.0,
    "question":"Can c1(C#N)c2c(sc1\\N=C\\c(ccc(c3[N+](=O)[O-])N4CCC(CC4)C)c3)CCCC2 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":78408
  },
  {
    "COADD_ID":"CO-ADD:0286276",
    "INHIB_AVE":4.55,
    "SMILES":"N1(CNc2ccccc2C(OCC)=O)N=C(OC1=S)c(cc3)ccc3C(C)(C)C",
    "HIT":0.0,
    "question":"Can N1(CNc2ccccc2C(OCC)=O)N=C(OC1=S)c(cc3)ccc3C(C)(C)C effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":37675
  },
  {
    "COADD_ID":"CO-ADD:0287180",
    "INHIB_AVE":14.3,
    "SMILES":"C1(C2c(ccs3)c3)=C(c4c(cccc4)NC1=O)OC(N)=C2C#N.C(=O)O",
    "HIT":0.0,
    "question":"Does treatment with C1(C2c(ccs3)c3)=C(c4c(cccc4)NC1=O)OC(N)=C2C#N.C(=O)O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":8563
  },
  {
    "COADD_ID":"CO-ADD:0223695",
    "INHIB_AVE":-1.12,
    "SMILES":"C(COc1c(C)ccc(C(C)C)c1)(=O)N\\N=C\\c2cccc(Cl)c2",
    "HIT":0.0,
    "question":"Does C(COc1c(C)ccc(C(C)C)c1)(=O)N\\N=C\\c2cccc(Cl)c2 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":61475
  },
  {
    "COADD_ID":"CO-ADD:0234938",
    "INHIB_AVE":15.31,
    "SMILES":"n1c(N(CC2)CCO2)nc(nc1N(CC3)CCO3)N\\N=C\\c(ccc4c5ccc(cc5Cl)[N+](=O)[O-])o4",
    "HIT":0.0,
    "question":"Is n1c(N(CC2)CCO2)nc(nc1N(CC3)CCO3)N\\N=C\\c(ccc4c5ccc(cc5Cl)[N+](=O)[O-])o4 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":7192
  },
  {
    "COADD_ID":"CO-ADD:0234599",
    "INHIB_AVE":-2.01,
    "SMILES":"[N+](=O)([O-])c1ccccc1OCC(=O)N\\N=C\\c(cc2)cc(c2OC(=O)c3ccccc3Br)OC",
    "HIT":0.0,
    "question":"Is [N+](=O)([O-])c1ccccc1OCC(=O)N\\N=C\\c(cc2)cc(c2OC(=O)c3ccccc3Br)OC effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":64359
  },
  {
    "COADD_ID":"CO-ADD:0258359",
    "INHIB_AVE":-1.35,
    "SMILES":"c1(SCC(=O)c2ccc(cc2)Br)sc3c(ccc(c3)NC(=O)c4cccc(C)c4)n1",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(SCC(=O)c2ccc(cc2)Br)sc3c(ccc(c3)NC(=O)c4cccc(C)c4)n1?",
    "answer":"No",
    "_id":62232
  },
  {
    "COADD_ID":"CO-ADD:0300503",
    "INHIB_AVE":1.15,
    "SMILES":"c1(CC2(C)C)c(ccc(cccc3)c13)C(=N2)COc4cc(C)ccc4C(C)C.Cl",
    "HIT":0.0,
    "question":"Is c1(CC2(C)C)c(ccc(cccc3)c13)C(=N2)COc4cc(C)ccc4C(C)C.Cl effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":52871
  },
  {
    "COADD_ID":"CO-ADD:0230639",
    "INHIB_AVE":1.33,
    "SMILES":"C(C#N)(C(c1ccc(c2c1)OCO2)=C(C#N)C(N3N)=O)=C3N",
    "HIT":0.0,
    "question":"Does C(C#N)(C(c1ccc(c2c1)OCO2)=C(C#N)C(N3N)=O)=C3N show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":52053
  },
  {
    "COADD_ID":"CO-ADD:0321194",
    "INHIB_AVE":6.7,
    "SMILES":"[nH]1c(cccc2)c2c(CCNC(=O)c3c(cccc3F)F)c1C",
    "HIT":0.0,
    "question":"Does [nH]1c(cccc2)c2c(CCNC(=O)c3c(cccc3F)F)c1C show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":28286
  },
  {
    "COADD_ID":"CO-ADD:0302754",
    "INHIB_AVE":8.44,
    "SMILES":"n1(c(cccc2C)c2n3)c3S\\C(=C\/c(cc4OC)cc(c4O)OC)\\C1=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound n1(c(cccc2C)c2n3)c3S\\C(=C\/c(cc4OC)cc(c4O)OC)\\C1=O?",
    "answer":"No",
    "_id":21656
  },
  {
    "COADD_ID":"CO-ADD:0226293",
    "INHIB_AVE":8.29,
    "SMILES":"S(=O)(=O)(N(Cc(cc1)ccc1F)c2cc(F)cc(F)c2)c(ccc3n4c(C)nn3)c4",
    "HIT":0.0,
    "question":"Is S(=O)(=O)(N(Cc(cc1)ccc1F)c2cc(F)cc(F)c2)c(ccc3n4c(C)nn3)c4 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":22157
  },
  {
    "COADD_ID":"CO-ADD:0258400",
    "INHIB_AVE":14.44,
    "SMILES":"N1(c2ccc(c(Cl)c2)C)C(=O)C(C(C1=O)C34CO)C(c(c35)cccc5)c(c46)cccc6",
    "HIT":0.0,
    "question":"Does treatment with N1(c2ccc(c(Cl)c2)C)C(=O)C(C(C1=O)C34CO)C(c(c35)cccc5)c(c46)cccc6 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":8331
  },
  {
    "COADD_ID":"CO-ADD:0234272",
    "INHIB_AVE":3.06,
    "SMILES":"C(=N\\NC(CNC(=O)c1ccc(cc1)Cl)=O)(\/C2=O)\\c3c(N2)ccc(c3)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Can exposure to C(=N\\NC(CNC(=O)c1ccc(cc1)Cl)=O)(\/C2=O)\\c3c(N2)ccc(c3)[N+](=O)[O-] lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":44355
  },
  {
    "COADD_ID":"CO-ADD:0330996",
    "INHIB_AVE":-3.49,
    "SMILES":"N12C(C=CC=C1C)=NC(CC2(C)C(O)=O)=O",
    "HIT":0.0,
    "question":"Can exposure to N12C(C=CC=C1C)=NC(CC2(C)C(O)=O)=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":68494
  },
  {
    "COADD_ID":"CO-ADD:0222607",
    "INHIB_AVE":7.59,
    "SMILES":"c1(ccccc1OCCC)C(NCCCC(=O)[O-])=O.[Na+]",
    "HIT":0.0,
    "question":"Can exposure to c1(ccccc1OCCC)C(NCCCC(=O)[O-])=O.[Na+] lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":24709
  },
  {
    "COADD_ID":"CO-ADD:0158673",
    "INHIB_AVE":-2.22,
    "SMILES":"O=C(COC(C(Br)=C1)=CC=C1OC)N\/N=C\/C2=CC=C3OCOC3=C2",
    "HIT":0.0,
    "question":"Is O=C(COC(C(Br)=C1)=CC=C1OC)N\/N=C\/C2=CC=C3OCOC3=C2 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":65017
  },
  {
    "COADD_ID":"CO-ADD:0225488",
    "INHIB_AVE":7.47,
    "SMILES":"C1(=N2)N(C=Cn(nc(c3ccc(cc3)OC)c4)c14)C(N2CC(=O)Nc5ccccc5)=O",
    "HIT":0.0,
    "question":"Does C1(=N2)N(C=Cn(nc(c3ccc(cc3)OC)c4)c14)C(N2CC(=O)Nc5ccccc5)=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":25174
  },
  {
    "COADD_ID":"CO-ADD:0218449",
    "INHIB_AVE":9.36,
    "SMILES":"C(=O)(N\\N=C\\c1cccc(OC)c1O)c2ccc(c(OC)c2)OC",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C(=O)(N\\N=C\\c1cccc(OC)c1O)c2ccc(c(OC)c2)OC?",
    "answer":"No",
    "_id":18874
  },
  {
    "COADD_ID":"CO-ADD:0255731",
    "INHIB_AVE":-1.32,
    "SMILES":"C1(c2ccccc2F)=Nc(cccc3)c3C(=O)N1CCc4ccccc4",
    "HIT":0.0,
    "question":"Does C1(c2ccccc2F)=Nc(cccc3)c3C(=O)N1CCc4ccccc4 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":62155
  },
  {
    "COADD_ID":"CO-ADD:0303541",
    "INHIB_AVE":1.17,
    "SMILES":"C1(=C(C)NC(=C2C1c(cc3OC)cc(c3OC)OC)CCCC2=O)C(=O)Nc4ccccc4C",
    "HIT":0.0,
    "question":"Does C1(=C(C)NC(=C2C1c(cc3OC)cc(c3OC)OC)CCCC2=O)C(=O)Nc4ccccc4C demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":52769
  },
  {
    "COADD_ID":"CO-ADD:0244296",
    "INHIB_AVE":20.34,
    "SMILES":"C(=C\\c(ccc(c1OC)OC)c1)\/C(OC)=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C(=C\\c(ccc(c1OC)OC)c1)\/C(OC)=O?",
    "answer":"No",
    "_id":2677
  },
  {
    "COADD_ID":"CO-ADD:0243013",
    "INHIB_AVE":17.87,
    "SMILES":"c1(c2OC)c(OCO1)c(cc2CC(CC(=N3)CNCCc(cc4)ccc4C)O3)OC.Cl",
    "HIT":0.0,
    "question":"Is c1(c2OC)c(OCO1)c(cc2CC(CC(=N3)CNCCc(cc4)ccc4C)O3)OC.Cl effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":4424
  },
  {
    "COADD_ID":"CO-ADD:0259408",
    "INHIB_AVE":9.85,
    "SMILES":"c1(N(CC2)CCO2)nc(N\\N=C\\c3cc(OCO4)c4cc3[N+](=O)[O-])nc(NCc5ccccc5)n1.Cl",
    "HIT":0.0,
    "question":"Can c1(N(CC2)CCO2)nc(N\\N=C\\c3cc(OCO4)c4cc3[N+](=O)[O-])nc(NCc5ccccc5)n1.Cl effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":17431
  },
  {
    "COADD_ID":"CO-ADD:0223809",
    "INHIB_AVE":10.7,
    "SMILES":"C(=C\/c(cc1)ccc1OCCC)(\/NC(c2ccccc2)=O)\\C(=O)N\\N=C(\/C)\\c3ccccc3",
    "HIT":0.0,
    "question":"Can C(=C\/c(cc1)ccc1OCCC)(\/NC(c2ccccc2)=O)\\C(=O)N\\N=C(\/C)\\c3ccccc3 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":15221
  },
  {
    "COADD_ID":"CO-ADD:0259902",
    "INHIB_AVE":-5.92,
    "SMILES":"S(=O)(=O)(c1ccc(cc1)C)N\\N=C\\c2cc(ccc2N(CCCC3C(=O)N(CC)CC)C3)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Is S(=O)(=O)(c1ccc(cc1)C)N\\N=C\\c2cc(ccc2N(CCCC3C(=O)N(CC)CC)C3)[N+](=O)[O-] capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":73582
  },
  {
    "COADD_ID":"CO-ADD:0217941",
    "INHIB_AVE":9.69,
    "SMILES":"C(=O)(Cc1ccccc1)N(CC2)CCO2",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C(=O)(Cc1ccccc1)N(CC2)CCO2?",
    "answer":"No",
    "_id":17888
  },
  {
    "COADD_ID":"CO-ADD:0240543",
    "INHIB_AVE":4.91,
    "SMILES":"c1(C(=O)Oc2ccccc2\\C=N\\c3cccc(cccc4)c34)c(Cl)c5c(cccc5)s1",
    "HIT":0.0,
    "question":"Does c1(C(=O)Oc2ccccc2\\C=N\\c3cccc(cccc4)c34)c(Cl)c5c(cccc5)s1 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":36034
  },
  {
    "COADD_ID":"CO-ADD:0252900",
    "INHIB_AVE":1.28,
    "SMILES":"n1(c2cccc(cccc3)c23)nnnc1N\\N=C\\c(cc4)ccc4F",
    "HIT":0.0,
    "question":"Can n1(c2cccc(cccc3)c23)nnnc1N\\N=C\\c(cc4)ccc4F effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":52261
  },
  {
    "COADD_ID":"CO-ADD:0292054",
    "INHIB_AVE":14.35,
    "SMILES":"n(c(c1ccc(c(C)c1)C)c2)c3c(c2C(=O)Nc4ccccc4Cl)cccc3Cl",
    "HIT":0.0,
    "question":"Does the proposed molecule n(c(c1ccc(c(C)c1)C)c2)c3c(c2C(=O)Nc4ccccc4Cl)cccc3Cl exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":8492
  },
  {
    "COADD_ID":"CO-ADD:0159675",
    "INHIB_AVE":7.13,
    "SMILES":"FC(F)(C([O-])=O)F.FC(F)(C([O-])=O)F.FC(F)(C([O-])=O)F.O=C(NCCCN1N=NC(CN2CC[N+]([H])([H])CCC[N+]([H])([H])CC[N+]([H])([H])CCC2)=C1)CCCC[C@@H]3SC[C@H](N4)[C@@H]3NC4=O",
    "HIT":0.0,
    "question":"Does FC(F)(C([O-])=O)F.FC(F)(C([O-])=O)F.FC(F)(C([O-])=O)F.O=C(NCCCN1N=NC(CN2CC[N+]([H])([H])CCC[N+]([H])([H])CC[N+]([H])([H])CCC2)=C1)CCCC[C@@H]3SC[C@H](N4)[C@@H]3NC4=O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":26502
  },
  {
    "COADD_ID":"CO-ADD:0323108",
    "INHIB_AVE":7.18,
    "SMILES":"C1(C#Cc2ccccc2)C3=C(CCCC3=O)OC(CCCC4=O)=C14",
    "HIT":0.0,
    "question":"Does treatment with C1(C#Cc2ccccc2)C3=C(CCCC3=O)OC(CCCC4=O)=C14 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":26292
  },
  {
    "COADD_ID":"CO-ADD:0323442",
    "INHIB_AVE":1.1,
    "SMILES":"O(c1ccccc1)CC(CNCCCO)O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound O(c1ccccc1)CC(CNCCCO)O?",
    "answer":"No",
    "_id":53035
  },
  {
    "COADD_ID":"CO-ADD:0220261",
    "INHIB_AVE":11.56,
    "SMILES":"c1(O)c(I)cc(cc1I)\\C=N\\NC(CNc(cc2)ccc2C)=O",
    "HIT":0.0,
    "question":"Can exposure to c1(O)c(I)cc(cc1I)\\C=N\\NC(CNc(cc2)ccc2C)=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":13322
  },
  {
    "COADD_ID":"CO-ADD:0311142",
    "INHIB_AVE":-6.49,
    "SMILES":"c1(cc(ccc1N2CCCCC2)c3oc(nn3)C)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Can c1(cc(ccc1N2CCCCC2)c3oc(nn3)C)[N+](=O)[O-] act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":74539
  },
  {
    "COADD_ID":"CO-ADD:0301485",
    "INHIB_AVE":-6.76,
    "SMILES":"C1(=NC(Cc(cc(OC)c(OC)c2)c12)(C)C)C3=NC(Cc(cccc4)c34)(C)C",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C1(=NC(Cc(cc(OC)c(OC)c2)c12)(C)C)C3=NC(Cc(cccc4)c34)(C)C?",
    "answer":"No",
    "_id":74959
  },
  {
    "COADD_ID":"CO-ADD:0293320",
    "INHIB_AVE":6.02,
    "SMILES":"c1(c(ccc(C)c1Br)NC2=O)C2=O",
    "HIT":0.0,
    "question":"Does c1(c(ccc(C)c1Br)NC2=O)C2=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":31153
  },
  {
    "COADD_ID":"CO-ADD:0226844",
    "INHIB_AVE":13.61,
    "SMILES":"C1(=N2)N(c3c(cccc3)N=C1Oc4cccc(C)c4C)C(N2CC(=O)Nc(ccc(c56)OCCO5)c6)=O",
    "HIT":0.0,
    "question":"Can C1(=N2)N(c3c(cccc3)N=C1Oc4cccc(C)c4C)C(N2CC(=O)Nc(ccc(c56)OCCO5)c6)=O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":9613
  },
  {
    "COADD_ID":"CO-ADD:0235059",
    "INHIB_AVE":3.71,
    "SMILES":"n1c(c2ccccc2)c3c(nc1c4ccc(cc4)NC(CCl)=O)ccc(c3)NC(CCl)=O",
    "HIT":0.0,
    "question":"Can exposure to n1c(c2ccccc2)c3c(nc1c4ccc(cc4)NC(CCl)=O)ccc(c3)NC(CCl)=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":41437
  },
  {
    "COADD_ID":"CO-ADD:0238633",
    "INHIB_AVE":99.39,
    "SMILES":"CC1=C(C2=CC=C(C=C2)C3=CC=CC=C3)C(C)=C(C)C1C.NC4=NC(N(C)C)=N[Ir@](C)(N4)Cl",
    "HIT":1.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound CC1=C(C2=CC=C(C=C2)C3=CC=CC=C3)C(C)=C(C)C1C.NC4=NC(N(C)C)=N[Ir@](C)(N4)Cl?",
    "answer":"Yes",
    "_id":153
  },
  {
    "COADD_ID":"CO-ADD:0287777",
    "INHIB_AVE":-10.66,
    "SMILES":"S(c1ccccc1)(=O)(=O)NC(C(Cl)(Cl)Cl)c2c3c([nH]c2C)cccc3",
    "HIT":0.0,
    "question":"Is S(c1ccccc1)(=O)(=O)NC(C(Cl)(Cl)Cl)c2c3c([nH]c2C)cccc3 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":79179
  },
  {
    "COADD_ID":"CO-ADD:0324609",
    "INHIB_AVE":4.1,
    "SMILES":"S(=O)(=O)(c(cc1)ccc1N2CCCC2=O)Nc3cc(on3)C",
    "HIT":0.0,
    "question":"Does S(=O)(=O)(c(cc1)ccc1N2CCCC2=O)Nc3cc(on3)C demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":39701
  },
  {
    "COADD_ID":"CO-ADD:0283313",
    "INHIB_AVE":5.32,
    "SMILES":"N1(c2ccccc2)C(C(SC1=S)(C)C)\\[N+](\\[O-])=C\\c3c4c([nH]c3)cccc4",
    "HIT":0.0,
    "question":"Does treatment with N1(c2ccccc2)C(C(SC1=S)(C)C)\\[N+](\\[O-])=C\\c3c4c([nH]c3)cccc4 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":34255
  },
  {
    "COADD_ID":"CO-ADD:0284019",
    "INHIB_AVE":16.79,
    "SMILES":"S(=O)(=O)(N1CCC(CC1)C)c2c(C)ccc(c2)C(=O)Oc3cccc(cccn4)c34",
    "HIT":0.0,
    "question":"Is S(=O)(=O)(N1CCC(CC1)C)c2c(C)ccc(c2)C(=O)Oc3cccc(cccn4)c34 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":5480
  },
  {
    "COADD_ID":"CO-ADD:0331322",
    "INHIB_AVE":18.46,
    "SMILES":"C1(C(F)(F)F)(NC(=O)c2ccc(cc2)F)C(=O)N(C(=O)N1)C",
    "HIT":0.0,
    "question":"Does treatment with C1(C(F)(F)F)(NC(=O)c2ccc(cc2)F)C(=O)N(C(=O)N1)C result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":3925
  },
  {
    "COADD_ID":"CO-ADD:0302538",
    "INHIB_AVE":-11.56,
    "SMILES":"c12c(ccc(cccc3)c13)C(CC(=O)N2)c4ccc(c(F)c4)F",
    "HIT":0.0,
    "question":"Is c12c(ccc(cccc3)c13)C(CC(=O)N2)c4ccc(c(F)c4)F effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":79755
  },
  {
    "COADD_ID":"CO-ADD:0256110",
    "INHIB_AVE":18.86,
    "SMILES":"c1(N(C)C)nc(N\\N=C\/c(ccc(c2OC)O)c2)nc(Nc(cc3)ccc3F)n1.Cl",
    "HIT":0.0,
    "question":"Can c1(N(C)C)nc(N\\N=C\/c(ccc(c2OC)O)c2)nc(Nc(cc3)ccc3F)n1.Cl act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":3620
  },
  {
    "COADD_ID":"CO-ADD:0155443",
    "INHIB_AVE":7.03,
    "SMILES":"[O-][N+](C1=CC(C(C(O\/2)=O)=NC2=C\\C(C)=C\\C3=CC=C(C=C3)\/C=C(C)\/C=C4N=C(C(O\/4)=O)C5=CC([N+]([O-])=O)=CC=C5)=CC=C1)=O",
    "HIT":0.0,
    "question":"Is [O-][N+](C1=CC(C(C(O\/2)=O)=NC2=C\\C(C)=C\\C3=CC=C(C=C3)\/C=C(C)\/C=C4N=C(C(O\/4)=O)C5=CC([N+]([O-])=O)=CC=C5)=CC=C1)=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":26848
  },
  {
    "COADD_ID":"CO-ADD:0256250",
    "INHIB_AVE":1.24,
    "SMILES":"c1(scc(c2ccc(cc2)Br)n1)NC(=O)\\C=C\\c3ccco3",
    "HIT":0.0,
    "question":"Can exposure to c1(scc(c2ccc(cc2)Br)n1)NC(=O)\\C=C\\c3ccco3 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":52395
  },
  {
    "COADD_ID":"CO-ADD:0231093",
    "INHIB_AVE":3.03,
    "SMILES":"c1(\\C=N\\NC(CCC(=O)Nc2cccc(Br)c2)=O)c(O)ccc(cccc3)c13",
    "HIT":0.0,
    "question":"Does treatment with c1(\\C=N\\NC(CCC(=O)Nc2cccc(Br)c2)=O)c(O)ccc(cccc3)c13 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":44499
  },
  {
    "COADD_ID":"CO-ADD:0321271",
    "INHIB_AVE":3.22,
    "SMILES":"S(=O)(=O)(CC(C12)CC(N1c3ccc(cc3)OC)=O)C2",
    "HIT":0.0,
    "question":"Can exposure to S(=O)(=O)(CC(C12)CC(N1c3ccc(cc3)OC)=O)C2 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":43621
  },
  {
    "COADD_ID":"CO-ADD:0259360",
    "INHIB_AVE":16.74,
    "SMILES":"C(C(OCC)=O)(=C(CCC)OC(=C1C#N)N)C1c2ccc(cc2)OC",
    "HIT":0.0,
    "question":"Does C(C(OCC)=O)(=C(CCC)OC(=C1C#N)N)C1c2ccc(cc2)OC demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":5545
  },
  {
    "COADD_ID":"CO-ADD:0235573",
    "INHIB_AVE":7.52,
    "SMILES":"c1(NC(Cc2ccccc2)=O)nnc(C)s1",
    "HIT":0.0,
    "question":"Does treatment with c1(NC(Cc2ccccc2)=O)nnc(C)s1 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":25003
  },
  {
    "COADD_ID":"CO-ADD:0323963",
    "INHIB_AVE":12.27,
    "SMILES":"S(NCCOC(CC1CC2CC3C1)(C3)C2)(=O)(=O)c4c(C)cc(cc4C)C",
    "HIT":0.0,
    "question":"Does the proposed molecule S(NCCOC(CC1CC2CC3C1)(C3)C2)(=O)(=O)c4c(C)cc(cc4C)C exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":11935
  },
  {
    "COADD_ID":"CO-ADD:0319321",
    "INHIB_AVE":-0.1,
    "SMILES":"n1(c2ccccc2)c(SCc(cc3)ccc3Br)nnc1c(cc4)ccc4C(C)(C)C",
    "HIT":0.0,
    "question":"Does n1(c2ccccc2)c(SCc(cc3)ccc3Br)nnc1c(cc4)ccc4C(C)(C)C demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":57869
  },
  {
    "COADD_ID":"CO-ADD:0256721",
    "INHIB_AVE":-9.26,
    "SMILES":"c1(c(ccc(c1)C(F)(F)F)Oc(cc2)ccc2C(=O)Nc3ccccc3Cl)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Does c1(c(ccc(c1)C(F)(F)F)Oc(cc2)ccc2C(=O)Nc3ccccc3Cl)[N+](=O)[O-] demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":78119
  },
  {
    "COADD_ID":"CO-ADD:0285519",
    "INHIB_AVE":9.46,
    "SMILES":"N1(CN(CC2)CCN2c3ccccc3)c(cccc4)c4\\C(=N\\c(ccc(c5C)C)c5)\\C1=O",
    "HIT":0.0,
    "question":"Can N1(CN(CC2)CCN2c3ccccc3)c(cccc4)c4\\C(=N\\c(ccc(c5C)C)c5)\\C1=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":18571
  },
  {
    "COADD_ID":"CO-ADD:0219739",
    "INHIB_AVE":17.07,
    "SMILES":"C(CSCc(cc1)ccc1Cl)(=O)N\\N=C\\c(cc2)ccc2F",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C(CSCc(cc1)ccc1Cl)(=O)N\\N=C\\c(cc2)ccc2F?",
    "answer":"No",
    "_id":5206
  },
  {
    "COADD_ID":"CO-ADD:0245710",
    "INHIB_AVE":3.97,
    "SMILES":"c12n(c(nn1)SCCC)ncn2\\N=C\\c3cccs3",
    "HIT":0.0,
    "question":"Can c12n(c(nn1)SCCC)ncn2\\N=C\\c3cccs3 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":40302
  },
  {
    "COADD_ID":"CO-ADD:0299166",
    "INHIB_AVE":1.87,
    "SMILES":"C1(C#N)=C(N)OC(=C2C1c3cccc(OC)c3OC(=O)N(CC4)CCO4)CCCC2=O",
    "HIT":0.0,
    "question":"Can C1(C#N)=C(N)OC(=C2C1c3cccc(OC)c3OC(=O)N(CC4)CCO4)CCCC2=O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":49672
  },
  {
    "COADD_ID":"CO-ADD:0299741",
    "INHIB_AVE":5.6,
    "SMILES":"C(=O)(C(OC)c1ccccc1)NC2CC2",
    "HIT":0.0,
    "question":"Can C(=O)(C(OC)c1ccccc1)NC2CC2 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":32969
  },
  {
    "COADD_ID":"CO-ADD:0299621",
    "INHIB_AVE":-3.0,
    "SMILES":"c1(C(OCC)=O)c(cc(OC(C)=O)c(c2)Br)c2n(c3ccccc3)c1CN(CC4)CCN4CC#N",
    "HIT":0.0,
    "question":"Can c1(C(OCC)=O)c(cc(OC(C)=O)c(c2)Br)c2n(c3ccccc3)c1CN(CC4)CCN4CC#N act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":67244
  },
  {
    "COADD_ID":"CO-ADD:0301065",
    "INHIB_AVE":-11.04,
    "SMILES":"c1(c(ccc(c1)[N+](=O)[O-])OC(C)C)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Can exposure to c1(c(ccc(c1)[N+](=O)[O-])OC(C)C)[N+](=O)[O-] lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":79452
  },
  {
    "COADD_ID":"CO-ADD:0157318",
    "INHIB_AVE":16.16,
    "SMILES":"[O-][N+](C1=C(O)C(\/C=N\/C2=CC3=C(C=C2)N=C(C(F)(F)F)N3)=CC([N+]([O-])=O)=C1)=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound [O-][N+](C1=C(O)C(\/C=N\/C2=CC3=C(C=C2)N=C(C(F)(F)F)N3)=CC([N+]([O-])=O)=C1)=O?",
    "answer":"No",
    "_id":6178
  },
  {
    "COADD_ID":"CO-ADD:0247566",
    "INHIB_AVE":4.74,
    "SMILES":"n1c2c([nH]c1\\C=N\\NC(=O)c3ccc(cc3)Br)cccc2",
    "HIT":0.0,
    "question":"Does n1c2c([nH]c1\\C=N\\NC(=O)c3ccc(cc3)Br)cccc2 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":36838
  },
  {
    "COADD_ID":"CO-ADD:0243884",
    "INHIB_AVE":1.74,
    "SMILES":"c(cc1)(OC(=O)C(C(c(cc(OCO2)c23)cc3OC)CC(=O)NCc(cc4)ccc4F)=C5O)c5cc1",
    "HIT":0.0,
    "question":"Can c(cc1)(OC(=O)C(C(c(cc(OCO2)c23)cc3OC)CC(=O)NCc(cc4)ccc4F)=C5O)c5cc1 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":50251
  },
  {
    "COADD_ID":"CO-ADD:0249523",
    "INHIB_AVE":-1.43,
    "SMILES":"n1(nnc(C(=O)N\\N=C\\c2cccc(OC)c2)c1CN3CCCCCC3)c4nonc4N",
    "HIT":0.0,
    "question":"Is n1(nnc(C(=O)N\\N=C\\c2cccc(OC)c2)c1CN3CCCCCC3)c4nonc4N capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":62507
  },
  {
    "COADD_ID":"CO-ADD:0249228",
    "INHIB_AVE":-2.73,
    "SMILES":"c12c(c3c(NC(c(cc(C(C)(C)C)c(c4C(C)(C)C)O)c4)O1)cccc3)nnc(SCC)n2",
    "HIT":0.0,
    "question":"Does treatment with c12c(c3c(NC(c(cc(C(C)(C)C)c(c4C(C)(C)C)O)c4)O1)cccc3)nnc(SCC)n2 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":66466
  },
  {
    "COADD_ID":"CO-ADD:0240208",
    "INHIB_AVE":4.92,
    "SMILES":"N1(C(NCCCC)=O)c(ccc(c2)Cl)c2OC1=S",
    "HIT":0.0,
    "question":"Can exposure to N1(C(NCCCC)=O)c(ccc(c2)Cl)c2OC1=S lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":35999
  },
  {
    "COADD_ID":"CO-ADD:0319275",
    "INHIB_AVE":12.15,
    "SMILES":"c1(SCC(=O)Nc(cc2)ccc2C(C)C)sc(c3n1)cccc3",
    "HIT":0.0,
    "question":"Does the proposed molecule c1(SCC(=O)Nc(cc2)ccc2C(C)C)sc(c3n1)cccc3 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":12170
  },
  {
    "COADD_ID":"CO-ADD:0136380",
    "INHIB_AVE":-6.89,
    "SMILES":"O=C(C(CC=CC1OC(C)=O)C1C2O)c(ccc3)c2c3O",
    "HIT":0.0,
    "question":"Is O=C(C(CC=CC1OC(C)=O)C1C2O)c(ccc3)c2c3O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":75163
  },
  {
    "COADD_ID":"CO-ADD:0291138",
    "INHIB_AVE":1.85,
    "SMILES":"n1(c2c(n3)cccc2)c3S\\C(=C\/c(cc4)cc(c4OC(C)C(O)=O)OC)\\C1=O",
    "HIT":0.0,
    "question":"Can n1(c2c(n3)cccc2)c3S\\C(=C\/c(cc4)cc(c4OC(C)C(O)=O)OC)\\C1=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":49780
  },
  {
    "COADD_ID":"CO-ADD:0256055",
    "INHIB_AVE":-2.57,
    "SMILES":"c1(c(O)c(\\C=N\\Nc(nc(NCc2ccco2)nc3Nc(cc4)ccc4OC)n3)cc(c1)[N+](=O)[O-])[N+](=O)[O-].Cl",
    "HIT":0.0,
    "question":"Is c1(c(O)c(\\C=N\\Nc(nc(NCc2ccco2)nc3Nc(cc4)ccc4OC)n3)cc(c1)[N+](=O)[O-])[N+](=O)[O-].Cl effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":66019
  },
  {
    "COADD_ID":"CO-ADD:0162297",
    "INHIB_AVE":8.04,
    "SMILES":"C(COc(cc1)ccc1C(C)(C)CC(C)(C)C)(=O)N\\N=C\\c(cc2)ccc2C(O)=O",
    "HIT":0.0,
    "question":"Can C(COc(cc1)ccc1C(C)(C)CC(C)(C)C)(=O)N\\N=C\\c(cc2)ccc2C(O)=O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":23037
  },
  {
    "COADD_ID":"CO-ADD:0231110",
    "INHIB_AVE":11.69,
    "SMILES":"C(=O)(Nc(cc1)ccc1CC)C\\C(\\C)=N\\NC(COc2ccccc2C)=O",
    "HIT":0.0,
    "question":"Can C(=O)(Nc(cc1)ccc1CC)C\\C(\\C)=N\\NC(COc2ccccc2C)=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":13064
  },
  {
    "COADD_ID":"CO-ADD:0258334",
    "INHIB_AVE":7.31,
    "SMILES":"c1(nnc(COc(cc2)ccc2C(C)(C)C)s1)NC(=O)c3cccc(C)c3",
    "HIT":0.0,
    "question":"Is c1(nnc(COc(cc2)ccc2C(C)(C)C)s1)NC(=O)c3cccc(C)c3 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":25840
  },
  {
    "COADD_ID":"CO-ADD:0220466",
    "INHIB_AVE":7.43,
    "SMILES":"C(=O)(c1ccc(cc1)Br)Oc2ccc(cc2\\C=N\\NC(CNc3cccc(C)c3)=O)Br",
    "HIT":0.0,
    "question":"Does C(=O)(c1ccc(cc1)Br)Oc2ccc(cc2\\C=N\\NC(CNc3cccc(C)c3)=O)Br demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":25350
  },
  {
    "COADD_ID":"CO-ADD:0292188",
    "INHIB_AVE":-6.32,
    "SMILES":"C(=C\/c(cc(n1c2ccc(cc2)F)C)c1C)(\/C3=O)\\C(=O)N(C(=O)N3C)C",
    "HIT":0.0,
    "question":"Can C(=C\/c(cc(n1c2ccc(cc2)F)C)c1C)(\/C3=O)\\C(=O)N(C(=O)N3C)C effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":74271
  },
  {
    "COADD_ID":"CO-ADD:0233570",
    "INHIB_AVE":21.58,
    "SMILES":"C(=O)(c1cccc(F)c1)Oc2ccc(cc2OC)\\C=N\\NC(=O)C(O)c3ccccc3",
    "HIT":0.0,
    "question":"Is C(=O)(c1cccc(F)c1)Oc2ccc(cc2OC)\\C=N\\NC(=O)C(O)c3ccccc3 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":2096
  },
  {
    "COADD_ID":"CO-ADD:0217770",
    "INHIB_AVE":-2.68,
    "SMILES":"c1(N(CC)c2ccccc2)c(N(C)C)nc(c3n1)non3",
    "HIT":0.0,
    "question":"Is c1(N(CC)c2ccccc2)c(N(C)C)nc(c3n1)non3 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":66330
  },
  {
    "COADD_ID":"CO-ADD:0252690",
    "INHIB_AVE":-2.53,
    "SMILES":"C(\/N1C(Cc2ccccc2)CSC1=O)(=C(\/C(F)(F)F)\\C(F)(F)F)\\C(F)(F)C(F)(F)F",
    "HIT":0.0,
    "question":"Can C(\/N1C(Cc2ccccc2)CSC1=O)(=C(\/C(F)(F)F)\\C(F)(F)F)\\C(F)(F)C(F)(F)F act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":65890
  },
  {
    "COADD_ID":"CO-ADD:0255324",
    "INHIB_AVE":4.79,
    "SMILES":"c12c([nH]c([n+]3ccccc3)n1)C(N(C)C(=O)N2C)=O.[Cl-]",
    "HIT":0.0,
    "question":"Is c12c([nH]c([n+]3ccccc3)n1)C(N(C)C(=O)N2C)=O.[Cl-] effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":36605
  },
  {
    "COADD_ID":"CO-ADD:0236888",
    "INHIB_AVE":3.73,
    "SMILES":"C(=O)(C1CC=CCC1C(O)=O)Nc2ccccc2C",
    "HIT":0.0,
    "question":"Can C(=O)(C1CC=CCC1C(O)=O)Nc2ccccc2C effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":41363
  },
  {
    "COADD_ID":"CO-ADD:0234332",
    "INHIB_AVE":8.23,
    "SMILES":"[n+](c(C)cc(c1C#N)C)([C@]2([H])[C@@](S3)([H])CCC[C@@]2([H])I)c13.[I-].II",
    "HIT":0.0,
    "question":"Is [n+](c(C)cc(c1C#N)C)([C@]2([H])[C@@](S3)([H])CCC[C@@]2([H])I)c13.[I-].II capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":22378
  },
  {
    "COADD_ID":"CO-ADD:0215648",
    "INHIB_AVE":2.56,
    "SMILES":"C(=O)(C(=O)NCc1ccccc1Cl)Nc2cc(C)ccc2C",
    "HIT":0.0,
    "question":"Can C(=O)(C(=O)NCc1ccccc1Cl)Nc2cc(C)ccc2C effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":46621
  },
  {
    "COADD_ID":"CO-ADD:0234569",
    "INHIB_AVE":6.48,
    "SMILES":"C(=O)(c1cccc(F)c1)Oc2ccc(cc2OC)\\C=N\\NC(COc(ccc(c3C)C)c3)=O",
    "HIT":0.0,
    "question":"Can C(=O)(c1cccc(F)c1)Oc2ccc(cc2OC)\\C=N\\NC(COc(ccc(c3C)C)c3)=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":29222
  },
  {
    "COADD_ID":"CO-ADD:0278172",
    "INHIB_AVE":-14.27,
    "SMILES":"s1c(COc2cccc(C)c2C)nnc1N",
    "HIT":0.0,
    "question":"Can exposure to s1c(COc2cccc(C)c2C)nnc1N lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":81067
  },
  {
    "COADD_ID":"CO-ADD:0165920",
    "INHIB_AVE":10.47,
    "SMILES":"C(=O)(N\\N=C\\c1ccccc1OCCCCCCC)c2ccc(cc2)Cl",
    "HIT":0.0,
    "question":"Does C(=O)(N\\N=C\\c1ccccc1OCCCCCCC)c2ccc(cc2)Cl show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":15805
  },
  {
    "COADD_ID":"CO-ADD:0220668",
    "INHIB_AVE":8.38,
    "SMILES":"c1(N(CC2)CCO2)nc(N\\N=C\\c(c3)c(O)c(cc3[N+](=O)[O-])Br)nc(Nc(cccc4[N+](=O)[O-])c4)n1",
    "HIT":0.0,
    "question":"Can c1(N(CC2)CCO2)nc(N\\N=C\\c(c3)c(O)c(cc3[N+](=O)[O-])Br)nc(Nc(cccc4[N+](=O)[O-])c4)n1 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":21854
  },
  {
    "COADD_ID":"CO-ADD:0283128",
    "INHIB_AVE":7.33,
    "SMILES":"C(\/c(cccc1)c1CC2(C)C)(=C\\c3ccc(c4n3)cccc4)\\N2",
    "HIT":0.0,
    "question":"Does C(\/c(cccc1)c1CC2(C)C)(=C\\c3ccc(c4n3)cccc4)\\N2 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":25733
  },
  {
    "COADD_ID":"CO-ADD:0232573",
    "INHIB_AVE":7.86,
    "SMILES":"C(CCC1CCCC1)(=O)NC2CCCCCCC2",
    "HIT":0.0,
    "question":"Does C(CCC1CCCC1)(=O)NC2CCCCCCC2 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":23745
  },
  {
    "COADD_ID":"CO-ADD:0329859",
    "INHIB_AVE":5.23,
    "SMILES":"C1(C(=O)NC(C)(CC)C#C)=Cc(c2)c(OC1=O)ccc2[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C1(C(=O)NC(C)(CC)C#C)=Cc(c2)c(OC1=O)ccc2[N+](=O)[O-]?",
    "answer":"No",
    "_id":34632
  },
  {
    "COADD_ID":"CO-ADD:0305008",
    "INHIB_AVE":-3.36,
    "SMILES":"c1(Nc2ccccc2)nc(OC)nc(OCC(F)(F)F)n1",
    "HIT":0.0,
    "question":"Does c1(Nc2ccccc2)nc(OC)nc(OCC(F)(F)F)n1 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":68156
  },
  {
    "COADD_ID":"CO-ADD:0277791",
    "INHIB_AVE":-4.01,
    "SMILES":"c12c(c(ccc1Nc(cc3)ccc3OCC)no4)c4c5c(cccc5)C2=O",
    "HIT":0.0,
    "question":"Does c12c(c(ccc1Nc(cc3)ccc3OCC)no4)c4c5c(cccc5)C2=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":69774
  },
  {
    "COADD_ID":"CO-ADD:0311370",
    "INHIB_AVE":5.45,
    "SMILES":"C(C(OC)=O)(Nc1ccc(cn1)Br)(NC(C)=O)C(F)(F)F",
    "HIT":0.0,
    "question":"Is C(C(OC)=O)(Nc1ccc(cn1)Br)(NC(C)=O)C(F)(F)F effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":33673
  },
  {
    "COADD_ID":"CO-ADD:0157776",
    "INHIB_AVE":2.89,
    "SMILES":"O=C(C1=CC(OC)=C(OC)C=C1)NCC(N\/N=C\\C2=C(C=CC=C3)C3=CC4=C2C=CC=C4)=O",
    "HIT":0.0,
    "question":"Can exposure to O=C(C1=CC(OC)=C(OC)C=C1)NCC(N\/N=C\\C2=C(C=CC=C3)C3=CC4=C2C=CC=C4)=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":45168
  },
  {
    "COADD_ID":"CO-ADD:0331791",
    "INHIB_AVE":5.25,
    "SMILES":"C(C(OCCOC)=O)(=C(C)NC(=C12)CC(CC1=O)c3cccs3)C2c(cc(OC)c(c4[N+](=O)[O-])O)c4",
    "HIT":0.0,
    "question":"Does the proposed molecule C(C(OCCOC)=O)(=C(C)NC(=C12)CC(CC1=O)c3cccs3)C2c(cc(OC)c(c4[N+](=O)[O-])O)c4 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":34520
  },
  {
    "COADD_ID":"CO-ADD:0136865",
    "INHIB_AVE":-4.61,
    "SMILES":"C1(C)(C)CC(Nc2ccc(Nc3ccccc3)cc2)CC(C)(C)N1",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C1(C)(C)CC(Nc2ccc(Nc3ccccc3)cc2)CC(C)(C)N1?",
    "answer":"No",
    "_id":71053
  },
  {
    "COADD_ID":"CO-ADD:0155142",
    "INHIB_AVE":0.25,
    "SMILES":"O=C(NCC(N\/N=C\/C1=CC=C2OCOC2=C1)=O)C3=CC(OC)=C(OC)C(OC)=C3",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound O=C(NCC(N\/N=C\/C1=CC=C2OCOC2=C1)=O)C3=CC(OC)=C(OC)C(OC)=C3?",
    "answer":"No",
    "_id":56473
  },
  {
    "COADD_ID":"CO-ADD:0230838",
    "INHIB_AVE":15.06,
    "SMILES":"c(OC)(c(OC)c1)c(OC)cc1C(=O)N\\N=C(\/C)\\c2ccc(cc2)OCC",
    "HIT":0.0,
    "question":"Does treatment with c(OC)(c(OC)c1)c(OC)cc1C(=O)N\\N=C(\/C)\\c2ccc(cc2)OCC result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":7526
  },
  {
    "COADD_ID":"CO-ADD:0307524",
    "INHIB_AVE":9.3,
    "SMILES":"C1(C)(C)C(=O)C(C)C(OC1=O)c2ccc(c(OC)c2)OC",
    "HIT":0.0,
    "question":"Is C1(C)(C)C(=O)C(C)C(OC1=O)c2ccc(c(OC)c2)OC capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":19058
  },
  {
    "COADD_ID":"CO-ADD:0292138",
    "INHIB_AVE":-8.49,
    "SMILES":"n1(c2ccc(c(C)c2)C)nc(c3n1)ccc(NC(=O)c4cccc(OCC)c4)c3",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound n1(c2ccc(c(C)c2)C)nc(c3n1)ccc(NC(=O)c4cccc(OCC)c4)c3?",
    "answer":"No",
    "_id":77282
  },
  {
    "COADD_ID":"CO-ADD:0320706",
    "INHIB_AVE":-6.55,
    "SMILES":"c1(ccccc1NC(=O)c2ccc(cc2)OCc3ccccc3Cl)C(OC)=O",
    "HIT":0.0,
    "question":"Does treatment with c1(ccccc1NC(=O)c2ccc(cc2)OCc3ccccc3Cl)C(OC)=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":74641
  },
  {
    "COADD_ID":"CO-ADD:0219355",
    "INHIB_AVE":21.9,
    "SMILES":"C(=O)(c1ccc(cc1)F)Nc(cccc2C(=O)N\\N=C\\c3ccccc3)c2",
    "HIT":0.0,
    "question":"Does treatment with C(=O)(c1ccc(cc1)F)Nc(cccc2C(=O)N\\N=C\\c3ccccc3)c2 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":1963
  },
  {
    "COADD_ID":"CO-ADD:0306719",
    "INHIB_AVE":-6.37,
    "SMILES":"C(C(c1ccccc1)=O)C(c2ccc(cc2)OC)Nc(cc3)ccc3F.Cl",
    "HIT":0.0,
    "question":"Does treatment with C(C(c1ccccc1)=O)C(c2ccc(cc2)OC)Nc(cc3)ccc3F.Cl result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":74366
  },
  {
    "COADD_ID":"CO-ADD:0311650",
    "INHIB_AVE":9.16,
    "SMILES":"C(=O)(Nc1cccc(SC)c1)c(c2)cc(cn2)Br",
    "HIT":0.0,
    "question":"Can exposure to C(=O)(Nc1cccc(SC)c1)c(c2)cc(cn2)Br lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":19411
  },
  {
    "COADD_ID":"CO-ADD:0329214",
    "INHIB_AVE":-1.82,
    "SMILES":"S(C)(=O)(=O)N1CCC(CC1)OC",
    "HIT":0.0,
    "question":"Does treatment with S(C)(=O)(=O)N1CCC(CC1)OC result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":63810
  },
  {
    "COADD_ID":"CO-ADD:0135792",
    "INHIB_AVE":-6.88,
    "SMILES":"c1([N+](=O)[O-])ccc(n([H])c(N)n2)c2c1",
    "HIT":0.0,
    "question":"Is c1([N+](=O)[O-])ccc(n([H])c(N)n2)c2c1 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":75157
  },
  {
    "COADD_ID":"CO-ADD:0245025",
    "INHIB_AVE":-5.54,
    "SMILES":"c1(SCC(=O)Nc2c(CC)cccc2CC)sc3c(ccc(c3)\\N=C\\c(c(O)ccc4[N+](=O)[O-])c4)n1",
    "HIT":0.0,
    "question":"Is c1(SCC(=O)Nc2c(CC)cccc2CC)sc3c(ccc(c3)\\N=C\\c(c(O)ccc4[N+](=O)[O-])c4)n1 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":72904
  },
  {
    "COADD_ID":"CO-ADD:0217081",
    "INHIB_AVE":-0.75,
    "SMILES":"C(=O)(N\\N=C\\c1ccccc1Cl)C(NCCC)=O",
    "HIT":0.0,
    "question":"Can C(=O)(N\\N=C\\c1ccccc1Cl)C(NCCC)=O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":60256
  },
  {
    "COADD_ID":"CO-ADD:0232767",
    "INHIB_AVE":-8.03,
    "SMILES":"C1(C2=O)C(NN=C1C(OCC)=O)C(N2c3ccc(cc3)OCC)=O",
    "HIT":0.0,
    "question":"Can C1(C2=O)C(NN=C1C(OCC)=O)C(N2c3ccc(cc3)OCC)=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":76754
  },
  {
    "COADD_ID":"CO-ADD:0311885",
    "INHIB_AVE":12.37,
    "SMILES":"C(=O)(NNc1c(Cl)ccc(Cl)c1)C(O)(c2ccc(cc2)Cl)c3ccc(cc3)Cl",
    "HIT":0.0,
    "question":"Can exposure to C(=O)(NNc1c(Cl)ccc(Cl)c1)C(O)(c2ccc(cc2)Cl)c3ccc(cc3)Cl lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":11723
  },
  {
    "COADD_ID":"CO-ADD:0310861",
    "INHIB_AVE":-1.62,
    "SMILES":"C1(N(c2ccc(cc2)C)CCN1c3ccc(cc3)C)c4cc(Cl)cc(COCO5)c45",
    "HIT":0.0,
    "question":"Does C1(N(c2ccc(cc2)C)CCN1c3ccc(cc3)C)c4cc(Cl)cc(COCO5)c45 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":63154
  },
  {
    "COADD_ID":"CO-ADD:0249727",
    "INHIB_AVE":8.62,
    "SMILES":"c1(\\C=N\\NC(COc(cc2)ccc2Br)=O)c(OC)ccc(cccc3)c13",
    "HIT":0.0,
    "question":"Does treatment with c1(\\C=N\\NC(COc(cc2)ccc2Br)=O)c(OC)ccc(cccc3)c13 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":21102
  },
  {
    "COADD_ID":"CO-ADD:0227273",
    "INHIB_AVE":6.32,
    "SMILES":"C(=O)(c1ccc(cc1)Br)Oc2ccc(cc2OC)\\C=N\\NC(COc(cc3)ccc3C)=O",
    "HIT":0.0,
    "question":"Can C(=O)(c1ccc(cc1)Br)Oc2ccc(cc2OC)\\C=N\\NC(COc(cc3)ccc3C)=O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":29906
  },
  {
    "COADD_ID":"CO-ADD:0154332",
    "INHIB_AVE":2.84,
    "SMILES":"NC1=C2C(CCC2)=NC3=C1C(C4=CC=CC=C4OC)C(C(OCC)=O)=C(C)O3",
    "HIT":0.0,
    "question":"Does the proposed molecule NC1=C2C(CCC2)=NC3=C1C(C4=CC=CC=C4OC)C(C(OCC)=O)=C(C)O3 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":45378
  },
  {
    "COADD_ID":"CO-ADD:0283598",
    "INHIB_AVE":4.66,
    "SMILES":"N(c1c(C)ccc(Cl)c1)(C(=O)C(C2C34Br)C(Br)(c5c3cccc5)c6c4cccc6)C2=O",
    "HIT":0.0,
    "question":"Does N(c1c(C)ccc(Cl)c1)(C(=O)C(C2C34Br)C(Br)(c5c3cccc5)c6c4cccc6)C2=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":37169
  },
  {
    "COADD_ID":"CO-ADD:0305423",
    "INHIB_AVE":8.56,
    "SMILES":"C(NCCN(CC1)CCO1)(=O)C(N)=O",
    "HIT":0.0,
    "question":"Can exposure to C(NCCN(CC1)CCO1)(=O)C(N)=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":21291
  },
  {
    "COADD_ID":"CO-ADD:0232942",
    "INHIB_AVE":-1.95,
    "SMILES":"c1(c2)c(cc(OC)c2NC(=O)C\\C(\\C)=N\\NC(COc(cc3)ccc3Br)=O)c4c(cccc4)o1",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(c2)c(cc(OC)c2NC(=O)C\\C(\\C)=N\\NC(COc(cc3)ccc3Br)=O)c4c(cccc4)o1?",
    "answer":"No",
    "_id":64209
  },
  {
    "COADD_ID":"CO-ADD:0149356",
    "INHIB_AVE":11.19,
    "SMILES":"COc(ccc(C(C(c1cc(OCO2)c2c(OC)c1)=O)C#N)c3)c3",
    "HIT":0.0,
    "question":"Can exposure to COc(ccc(C(C(c1cc(OCO2)c2c(OC)c1)=O)C#N)c3)c3 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":14125
  },
  {
    "COADD_ID":"CO-ADD:0278127",
    "INHIB_AVE":-9.16,
    "SMILES":"C(=N\/c(cccc1C(F)(F)F)c1)(\/SC=C2c(cc3)ccc3c4ccccc4)\\N2CCc(cc5)ccc5S(N)(=O)=O.Br",
    "HIT":0.0,
    "question":"Can C(=N\/c(cccc1C(F)(F)F)c1)(\/SC=C2c(cc3)ccc3c4ccccc4)\\N2CCc(cc5)ccc5S(N)(=O)=O.Br effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":78006
  },
  {
    "COADD_ID":"CO-ADD:0300728",
    "INHIB_AVE":-3.14,
    "SMILES":"c1(cc(ccc1N(CC2)CCN2c3ccc(nn3)Cl)C(F)(F)F)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Is c1(cc(ccc1N(CC2)CCN2c3ccc(nn3)Cl)C(F)(F)F)[N+](=O)[O-] effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":67630
  },
  {
    "COADD_ID":"CO-ADD:0157872",
    "INHIB_AVE":2.19,
    "SMILES":"O=C(COC(C=C1)=CC=C1I)N\/N=C\/C2=C(OCC)C=CC(OC)=C2",
    "HIT":0.0,
    "question":"Can O=C(COC(C=C1)=CC=C1I)N\/N=C\/C2=C(OCC)C=CC(OC)=C2 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":48255
  },
  {
    "COADD_ID":"CO-ADD:0293121",
    "INHIB_AVE":4.61,
    "SMILES":"C12=C(CC(c3ccc(cc3)OC)CC1=O)Nc(c4NC2c5ccccc5OC(C)C)cccc4",
    "HIT":0.0,
    "question":"Does the proposed molecule C12=C(CC(c3ccc(cc3)OC)CC1=O)Nc(c4NC2c5ccccc5OC(C)C)cccc4 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":37410
  },
  {
    "COADD_ID":"CO-ADD:0323776",
    "INHIB_AVE":12.35,
    "SMILES":"c12c(ccc(N\\C(\\C)=C\\C(C)=O)c1OC)c(c(C)[nH]2)C",
    "HIT":0.0,
    "question":"Does treatment with c12c(ccc(N\\C(\\C)=C\\C(C)=O)c1OC)c(c(C)[nH]2)C result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":11757
  },
  {
    "COADD_ID":"CO-ADD:0259936",
    "INHIB_AVE":-13.92,
    "SMILES":"N1(C(=O)CSC1c2ccccc2)c3cccc(c3)C(=O)NC4(CCCCC4)C(=O)Nc5ccccc5",
    "HIT":0.0,
    "question":"Can N1(C(=O)CSC1c2ccccc2)c3cccc(c3)C(=O)NC4(CCCCC4)C(=O)Nc5ccccc5 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":80941
  },
  {
    "COADD_ID":"CO-ADD:0221895",
    "INHIB_AVE":3.07,
    "SMILES":"C(=O)(N\\N=C\\c(cc1)ccc1C(C)C)C(=O)Nc(cc2)ccc2OCCCCC",
    "HIT":0.0,
    "question":"Does treatment with C(=O)(N\\N=C\\c(cc1)ccc1C(C)C)C(=O)Nc(cc2)ccc2OCCCCC result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":44300
  },
  {
    "COADD_ID":"CO-ADD:0223196",
    "INHIB_AVE":-5.74,
    "SMILES":"c1(c(\\C=N\\NC(COc2ccccc2[N+](=O)[O-])=O)ccc(O)c1OC)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Does c1(c(\\C=N\\NC(COc2ccccc2[N+](=O)[O-])=O)ccc(O)c1OC)[N+](=O)[O-] demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":73228
  },
  {
    "COADD_ID":"CO-ADD:0253842",
    "INHIB_AVE":8.77,
    "SMILES":"S(=O)(=O)(c1ccc(c(OC)c1)OC)N(CCc2ccccc2)CC(=O)N\\N=C(\/C)\\C",
    "HIT":0.0,
    "question":"Can exposure to S(=O)(=O)(c1ccc(c(OC)c1)OC)N(CCc2ccccc2)CC(=O)N\\N=C(\/C)\\C lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":20652
  },
  {
    "COADD_ID":"CO-ADD:0329945",
    "INHIB_AVE":19.24,
    "SMILES":"C(=O)(N1CCCCC1)C2(CCCC2)c3ccc(c(OC)c3)OC",
    "HIT":0.0,
    "question":"Can C(=O)(N1CCCCC1)C2(CCCC2)c3ccc(c(OC)c3)OC effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":3362
  },
  {
    "COADD_ID":"CO-ADD:0305162",
    "INHIB_AVE":8.62,
    "SMILES":"C1(C(OCCc2ccccc2)=O)=C(C)NC(=C3C1c4cc(OC)c(cc4Br)OC)CCCC3=O",
    "HIT":0.0,
    "question":"Is C1(C(OCCc2ccccc2)=O)=C(C)NC(=C3C1c4cc(OC)c(cc4Br)OC)CCCC3=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":21088
  },
  {
    "COADD_ID":"CO-ADD:0301713",
    "INHIB_AVE":6.77,
    "SMILES":"C(=C\/c(cc1)ccc1OCCOc(cc2)ccc2[N+](=O)[O-])(\/C(=O)NC(N3)=O)\\C3=O",
    "HIT":0.0,
    "question":"Can C(=C\/c(cc1)ccc1OCCOc(cc2)ccc2[N+](=O)[O-])(\/C(=O)NC(N3)=O)\\C3=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":27976
  },
  {
    "COADD_ID":"CO-ADD:0244015",
    "INHIB_AVE":-20.63,
    "SMILES":"C1C[C@](C)(C([C@H](O)CC(\\C(=C(\\C(=O)OCc2ccccc2)\/CC\\C=C(\/C)\\C)\\[C@@H](OC(C)=O)C3)[C@]34C)[C@]4(C)CC5)C5[C@H](C)[C@@H]1OC(CCC(=O)OCCc6ccc(OCCO[N+]([O-])=O)cc6)=O",
    "HIT":0.0,
    "question":"Can C1C[C@](C)(C([C@H](O)CC(\\C(=C(\\C(=O)OCc2ccccc2)\/CC\\C=C(\/C)\\C)\\[C@@H](OC(C)=O)C3)[C@]34C)[C@]4(C)CC5)C5[C@H](C)[C@@H]1OC(CCC(=O)OCCc6ccc(OCCO[N+]([O-])=O)cc6)=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":82222
  },
  {
    "COADD_ID":"CO-ADD:0327906",
    "INHIB_AVE":9.04,
    "SMILES":"c1(SCC(=O)Nc2sccn2)nc(C)cc(C)c1C(N)=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(SCC(=O)Nc2sccn2)nc(C)cc(C)c1C(N)=O?",
    "answer":"No",
    "_id":19751
  },
  {
    "COADD_ID":"CO-ADD:0302376",
    "INHIB_AVE":28.73,
    "SMILES":"C(C(=O)Nc1ccccc1)(=C(C)NC(=C2C#N)SCC(=O)Nc(ccc(c34)cccc3)c4)C2c5cccs5",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C(C(=O)Nc1ccccc1)(=C(C)NC(=C2C#N)SCC(=O)Nc(ccc(c34)cccc3)c4)C2c5cccs5?",
    "answer":"No",
    "_id":829
  },
  {
    "COADD_ID":"CO-ADD:0324665",
    "INHIB_AVE":12.54,
    "SMILES":"S(NCCc(c1c([nH]2)ccc(OC)c1)c2C)(=O)(=O)c(cc3)ccc3C(C)C",
    "HIT":0.0,
    "question":"Can S(NCCc(c1c([nH]2)ccc(OC)c1)c2C)(=O)(=O)c(cc3)ccc3C(C)C act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":11408
  },
  {
    "COADD_ID":"CO-ADD:0295719",
    "INHIB_AVE":-10.63,
    "SMILES":"c1(NC(=S)NC(=O)c2ccc(cc2Cl)Cl)sc(c3c1C(N)=O)CCCC3",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(NC(=S)NC(=O)c2ccc(cc2Cl)Cl)sc(c3c1C(N)=O)CCCC3?",
    "answer":"No",
    "_id":79162
  },
  {
    "COADD_ID":"CO-ADD:0277548",
    "INHIB_AVE":4.52,
    "SMILES":"C(=O)(C1CC=CCC1C(O)=O)Nc(c(OC)ccc2C(C)(C)C)c2",
    "HIT":0.0,
    "question":"Can C(=O)(C1CC=CCC1C(O)=O)Nc(c(OC)ccc2C(C)(C)C)c2 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":37813
  },
  {
    "COADD_ID":"CO-ADD:0290452",
    "INHIB_AVE":94.0,
    "SMILES":"c1(C(O)=O)c(cc(cc1[N+](=O)[O-])[N+](=O)[O-])[N+](=O)[O-]",
    "HIT":1.0,
    "question":"Does treatment with c1(C(O)=O)c(cc(cc1[N+](=O)[O-])[N+](=O)[O-])[N+](=O)[O-] result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"Yes",
    "_id":17
  },
  {
    "COADD_ID":"CO-ADD:0311926",
    "INHIB_AVE":6.78,
    "SMILES":"c1(Sc2ccccc2C(O)=O)c(cc(cc1[N+](=O)[O-])C(F)(F)F)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Can c1(Sc2ccccc2C(O)=O)c(cc(cc1[N+](=O)[O-])C(F)(F)F)[N+](=O)[O-] effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":27912
  },
  {
    "COADD_ID":"CO-ADD:0329164",
    "INHIB_AVE":-1.77,
    "SMILES":"C(C(O)=O)(=CN1CC)C(=O)c(c12)cnc(N(CC3)CCN3C(=S)Nc(cc4)ccc4OC)n2",
    "HIT":0.0,
    "question":"Does treatment with C(C(O)=O)(=CN1CC)C(=O)c(c12)cnc(N(CC3)CCN3C(=S)Nc(cc4)ccc4OC)n2 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":63628
  },
  {
    "COADD_ID":"CO-ADD:0231472",
    "INHIB_AVE":1.39,
    "SMILES":"c1(c2ccc(cc2)\\N=C\\c(ccc(c3Cl)Cl)c3)sc(c4n1)cccc4",
    "HIT":0.0,
    "question":"Does the proposed molecule c1(c2ccc(cc2)\\N=C\\c(ccc(c3Cl)Cl)c3)sc(c4n1)cccc4 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":51765
  },
  {
    "COADD_ID":"CO-ADD:0318959",
    "INHIB_AVE":9.26,
    "SMILES":"c1(C(=O)N(C)C(N2C)=O)c2nc3n1cc(n3CCCO)c4ccc(cc4)OC",
    "HIT":0.0,
    "question":"Can exposure to c1(C(=O)N(C)C(N2C)=O)c2nc3n1cc(n3CCCO)c4ccc(cc4)OC lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":19152
  },
  {
    "COADD_ID":"CO-ADD:0289118",
    "INHIB_AVE":13.25,
    "SMILES":"c1([nH]c(cc1C)C)C(=O)N(CCCC2C(O)=O)C2",
    "HIT":0.0,
    "question":"Is c1([nH]c(cc1C)C)C(=O)N(CCCC2C(O)=O)C2 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":10175
  },
  {
    "COADD_ID":"CO-ADD:0240486",
    "INHIB_AVE":22.7,
    "SMILES":"C1(=S)N(c(cc2)ccc2C(OCC)=O)C3(\\C(=N\\c4cccc(C)c4)\\N1)CCCCC3",
    "HIT":0.0,
    "question":"Does C1(=S)N(c(cc2)ccc2C(OCC)=O)C3(\\C(=N\\c4cccc(C)c4)\\N1)CCCCC3 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":1713
  },
  {
    "COADD_ID":"CO-ADD:0331263",
    "INHIB_AVE":11.98,
    "SMILES":"c1(N(c2ccccc2)c3ccccc3)nc(n4cccc4)nc(N(CC5)CCO5)n1",
    "HIT":0.0,
    "question":"Can c1(N(c2ccccc2)c3ccccc3)nc(n4cccc4)nc(N(CC5)CCO5)n1 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":12470
  },
  {
    "COADD_ID":"CO-ADD:0294025",
    "INHIB_AVE":14.12,
    "SMILES":"N(c1sccn1)C(=O)c2cccc(cccc3)c23",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound N(c1sccn1)C(=O)c2cccc(cccc3)c23?",
    "answer":"No",
    "_id":8849
  },
  {
    "COADD_ID":"CO-ADD:0220066",
    "INHIB_AVE":11.75,
    "SMILES":"C12(CC3CC(CC(C3)C1)C2)c(cc4)ccc4C(C)C",
    "HIT":0.0,
    "question":"Can C12(CC3CC(CC(C3)C1)C2)c(cc4)ccc4C(C)C act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":12930
  },
  {
    "COADD_ID":"CO-ADD:0323033",
    "INHIB_AVE":2.13,
    "SMILES":"c12c(ccc(C(=O)Nc(cc3)ccc3Br)c1SCC)C(=O)c(c4C2=O)cccc4",
    "HIT":0.0,
    "question":"Is c12c(ccc(C(=O)Nc(cc3)ccc3Br)c1SCC)C(=O)c(c4C2=O)cccc4 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":48494
  },
  {
    "COADD_ID":"CO-ADD:0328305",
    "INHIB_AVE":-1.08,
    "SMILES":"C(C(=O)c1ccc(cc1)Cl)(C2c3cccc(O)c3)=C(O)C(N2c4ccc(c(Br)c4)C)=O",
    "HIT":0.0,
    "question":"Does the proposed molecule C(C(=O)c1ccc(cc1)Cl)(C2c3cccc(O)c3)=C(O)C(N2c4ccc(c(Br)c4)C)=O exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":61358
  },
  {
    "COADD_ID":"CO-ADD:0242462",
    "INHIB_AVE":1.53,
    "SMILES":"c1(SCc(cc2)ccc2Br)sc3c(ccc(c3)\\N=C\\c4ccccc4O)n1",
    "HIT":0.0,
    "question":"Is c1(SCc(cc2)ccc2Br)sc3c(ccc(c3)\\N=C\\c4ccccc4O)n1 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":51153
  },
  {
    "COADD_ID":"CO-ADD:0217695",
    "INHIB_AVE":2.53,
    "SMILES":"C1(C(=O)Nc2ccccc2Cl)C3C1CCCC3",
    "HIT":0.0,
    "question":"Can exposure to C1(C(=O)Nc2ccccc2Cl)C3C1CCCC3 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":46745
  },
  {
    "COADD_ID":"CO-ADD:0240511",
    "INHIB_AVE":-7.83,
    "SMILES":"N(C)(c1c(cc(C(=O)N\\N=C\\c(cc2)ccc2[N+](=O)[O-])c(C)n1)C(N3C)=O)C3=O",
    "HIT":0.0,
    "question":"Does N(C)(c1c(cc(C(=O)N\\N=C\\c(cc2)ccc2[N+](=O)[O-])c(C)n1)C(N3C)=O)C3=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":76515
  },
  {
    "COADD_ID":"CO-ADD:0235835",
    "INHIB_AVE":14.97,
    "SMILES":"N1(c2cccc(O)c2)C(=O)c3c(cc(cc3)Oc(cc4)ccc4[N+](=O)[O-])C1=O",
    "HIT":0.0,
    "question":"Can N1(c2cccc(O)c2)C(=O)c3c(cc(cc3)Oc(cc4)ccc4[N+](=O)[O-])C1=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":7634
  },
  {
    "COADD_ID":"CO-ADD:0305268",
    "INHIB_AVE":-1.65,
    "SMILES":"c1(n2)c(C(N(C)C(=O)N1C)=O)n(c23)CC(=NN3Cc4ccccc4)c5cccc(OC)c5",
    "HIT":0.0,
    "question":"Can c1(n2)c(C(N(C)C(=O)N1C)=O)n(c23)CC(=NN3Cc4ccccc4)c5cccc(OC)c5 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":63239
  },
  {
    "COADD_ID":"CO-ADD:0242614",
    "INHIB_AVE":8.84,
    "SMILES":"[N+](=O)([O-])c(ccc(c1\\C=N\\NC(COc(cc2)ccc2C(C)(C)C)=O)N(CC)CC)c1",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound [N+](=O)([O-])c(ccc(c1\\C=N\\NC(COc(cc2)ccc2C(C)(C)C)=O)N(CC)CC)c1?",
    "answer":"No",
    "_id":20394
  },
  {
    "COADD_ID":"CO-ADD:0253429",
    "INHIB_AVE":7.7,
    "SMILES":"s1c(SCC(=O)Nc2c(C)ccc(Cl)c2)nnc1SCC(=O)Nc3c(C)ccc(Cl)c3",
    "HIT":0.0,
    "question":"Can s1c(SCC(=O)Nc2c(C)ccc(Cl)c2)nnc1SCC(=O)Nc3c(C)ccc(Cl)c3 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":24325
  },
  {
    "COADD_ID":"CO-ADD:0326125",
    "INHIB_AVE":6.69,
    "SMILES":"S(=O)(=O)(NC(c1ccc(cc1)C)CC(OCC)=O)c2c(OC)ccc(Cl)c2",
    "HIT":0.0,
    "question":"Is S(=O)(=O)(NC(c1ccc(cc1)C)CC(OCC)=O)c2c(OC)ccc(Cl)c2 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":28310
  },
  {
    "COADD_ID":"CO-ADD:0284525",
    "INHIB_AVE":9.99,
    "SMILES":"c1(SC(CC)C(=O)Nc2ccc(cn2)Cl)nccn1C",
    "HIT":0.0,
    "question":"Does c1(SC(CC)C(=O)Nc2ccc(cn2)Cl)nccn1C demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":17028
  },
  {
    "COADD_ID":"CO-ADD:0255722",
    "INHIB_AVE":-26.87,
    "SMILES":"c(cc(O)cc1C)(C(=O)c2c(S3)cccc2)c13",
    "HIT":0.0,
    "question":"Can c(cc(O)cc1C)(C(=O)c2c(S3)cccc2)c13 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":82522
  },
  {
    "COADD_ID":"CO-ADD:0230366",
    "INHIB_AVE":1.33,
    "SMILES":"C(\/N)(\\SC)=N\/N=C\\c1ccccn1.I",
    "HIT":0.0,
    "question":"Does C(\/N)(\\SC)=N\/N=C\\c1ccccn1.I show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":52030
  },
  {
    "COADD_ID":"CO-ADD:0240409",
    "INHIB_AVE":17.55,
    "SMILES":"C(C#N)(C1c(cccc2[N+](=O)[O-])c2)=C(N)N(C(CC(C)(C)CC3=O)=C13)c4cccc(c4)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Can exposure to C(C#N)(C1c(cccc2[N+](=O)[O-])c2)=C(N)N(C(CC(C)(C)CC3=O)=C13)c4cccc(c4)[N+](=O)[O-] lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":4743
  },
  {
    "COADD_ID":"CO-ADD:0166775",
    "INHIB_AVE":14.79,
    "SMILES":"N1(c2ccc(cc2)Br)C(=O)C(CC1=O)SC(N\\N=C\\c(ccc(c3O)O)c3)=N",
    "HIT":0.0,
    "question":"Can N1(c2ccc(cc2)Br)C(=O)C(CC1=O)SC(N\\N=C\\c(ccc(c3O)O)c3)=N effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":7868
  },
  {
    "COADD_ID":"CO-ADD:0256450",
    "INHIB_AVE":3.91,
    "SMILES":"C(C)(CC(c(c12)cccc1)c(c34)cccc3)(C(=O)Nc5cccc(Cl)c5C)C24",
    "HIT":0.0,
    "question":"Can exposure to C(C)(CC(c(c12)cccc1)c(c34)cccc3)(C(=O)Nc5cccc(Cl)c5C)C24 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":40541
  },
  {
    "COADD_ID":"CO-ADD:0231370",
    "INHIB_AVE":10.05,
    "SMILES":"n1c2c(oc1c3ccc(c(Cl)c3)Cl)ccc(c2)\\N=C\\c4c(O)cc(c(Cl)c4C)C",
    "HIT":0.0,
    "question":"Is n1c2c(oc1c3ccc(c(Cl)c3)Cl)ccc(c2)\\N=C\\c4c(O)cc(c(Cl)c4C)C capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":16860
  },
  {
    "COADD_ID":"CO-ADD:0161940",
    "INHIB_AVE":2.82,
    "SMILES":"C(NCCCCCCCCCCCCCCCCCC)(=O)c1ccc(cc1)NC(CCCCCCC)=O",
    "HIT":0.0,
    "question":"Can exposure to C(NCCCCCCCCCCCCCCCCCC)(=O)c1ccc(cc1)NC(CCCCCCC)=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":45445
  },
  {
    "COADD_ID":"CO-ADD:0292965",
    "INHIB_AVE":14.04,
    "SMILES":"N1(O)C(C)(C)CC(CC1(C)C)NC(c2ccccc2)=O.Cl",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound N1(O)C(C)(C)CC(CC1(C)C)NC(c2ccccc2)=O.Cl?",
    "answer":"No",
    "_id":8978
  },
  {
    "COADD_ID":"CO-ADD:0218951",
    "INHIB_AVE":4.97,
    "SMILES":"C(C(c1ccc(cc1)Cl)Nc2cccc(Br)c2)C(=O)c3ccc(cc3)C",
    "HIT":0.0,
    "question":"Can C(C(c1ccc(cc1)Cl)Nc2cccc(Br)c2)C(=O)c3ccc(cc3)C act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":35761
  },
  {
    "COADD_ID":"CO-ADD:0231851",
    "INHIB_AVE":5.02,
    "SMILES":"c1(c2ccccc2C)oc(c3n1)ccc(c3)\\N=C\\c(ccc(c4Cl)OC)c4",
    "HIT":0.0,
    "question":"Does c1(c2ccccc2C)oc(c3n1)ccc(c3)\\N=C\\c(ccc(c4Cl)OC)c4 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":35540
  },
  {
    "COADD_ID":"CO-ADD:0155122",
    "INHIB_AVE":7.02,
    "SMILES":"O=C(C(C=C1)=CC=C1F)C2=C(N)C(C=C3C)=C(N=C3CC)S2",
    "HIT":0.0,
    "question":"Does O=C(C(C=C1)=CC=C1F)C2=C(N)C(C=C3C)=C(N=C3CC)S2 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":26914
  },
  {
    "COADD_ID":"CO-ADD:0221600",
    "INHIB_AVE":14.62,
    "SMILES":"N1(O)C(=O)CNC1c(cccc2[N+](=O)[O-])c2",
    "HIT":0.0,
    "question":"Is N1(O)C(=O)CNC1c(cccc2[N+](=O)[O-])c2 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":8096
  },
  {
    "COADD_ID":"CO-ADD:0225305",
    "INHIB_AVE":10.45,
    "SMILES":"N12C(C=CC(SCc(cc3)ccc3Cl)=N1)=NN(CC(=O)Nc4cccc(OC)c4)C2=O",
    "HIT":0.0,
    "question":"Can N12C(C=CC(SCc(cc3)ccc3Cl)=N1)=NN(CC(=O)Nc4cccc(OC)c4)C2=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":15855
  },
  {
    "COADD_ID":"CO-ADD:0285338",
    "INHIB_AVE":-0.17,
    "SMILES":"c12c(n(c(SCC(OCC)=O)n1)C)C(N(C)C(=O)N2C)=O",
    "HIT":0.0,
    "question":"Does treatment with c12c(n(c(SCC(OCC)=O)n1)C)C(N(C)C(=O)N2C)=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":58150
  },
  {
    "COADD_ID":"CO-ADD:0304632",
    "INHIB_AVE":3.29,
    "SMILES":"c1(NCc(cc2)ccc2C)nnnn1CCC",
    "HIT":0.0,
    "question":"Can exposure to c1(NCc(cc2)ccc2C)nnnn1CCC lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":43308
  },
  {
    "COADD_ID":"CO-ADD:0135924",
    "INHIB_AVE":-6.93,
    "SMILES":"n1cnc(c(cn2)c1NC)n2C(CCCC3)O3",
    "HIT":0.0,
    "question":"Can exposure to n1cnc(c(cn2)c1NC)n2C(CCCC3)O3 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":75226
  },
  {
    "COADD_ID":"CO-ADD:0300046",
    "INHIB_AVE":-10.32,
    "SMILES":"C(C#N)(C(CC(N1)=O)c(ccc(c2OCc3ccccc3)OC)c2)=C1SCC",
    "HIT":0.0,
    "question":"Does C(C#N)(C(CC(N1)=O)c(ccc(c2OCc3ccccc3)OC)c2)=C1SCC show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":78930
  },
  {
    "COADD_ID":"CO-ADD:0231207",
    "INHIB_AVE":0.66,
    "SMILES":"N(=C\\c(cc1)ccc1O)\/NC(CCCc(ccc(c2C)OC)c2)=O",
    "HIT":0.0,
    "question":"Can exposure to N(=C\\c(cc1)ccc1O)\/NC(CCCc(ccc(c2C)OC)c2)=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":54856
  },
  {
    "COADD_ID":"CO-ADD:0243386",
    "INHIB_AVE":15.51,
    "SMILES":"C12=C(OC(=O)CC1c(cc(OCO3)c3c4OC)c4OC)c5c(cccc5)NC2=O",
    "HIT":0.0,
    "question":"Is C12=C(OC(=O)CC1c(cc(OCO3)c3c4OC)c4OC)c5c(cccc5)NC2=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":6942
  },
  {
    "COADD_ID":"CO-ADD:0312609",
    "INHIB_AVE":12.75,
    "SMILES":"c(ccc(CC1C(C2C(=O)O)C(=O)N(C(C)C)C1)c23)c3",
    "HIT":0.0,
    "question":"Is c(ccc(CC1C(C2C(=O)O)C(=O)N(C(C)C)C1)c23)c3 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":11039
  },
  {
    "COADD_ID":"CO-ADD:0245359",
    "INHIB_AVE":-0.99,
    "SMILES":"N1(c2ccccc2)C(=O)c(c3C1=O)ccc(c3)N4Cc5c(cccc5)C4",
    "HIT":0.0,
    "question":"Can exposure to N1(c2ccccc2)C(=O)c(c3C1=O)ccc(c3)N4Cc5c(cccc5)C4 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":61083
  },
  {
    "COADD_ID":"CO-ADD:0311738",
    "INHIB_AVE":2.23,
    "SMILES":"c1(NC(=O)c2ccccc2[N+](=O)[O-])nnnn1\\N=C\\c(cc3)ccc3F",
    "HIT":0.0,
    "question":"Can exposure to c1(NC(=O)c2ccccc2[N+](=O)[O-])nnnn1\\N=C\\c(cc3)ccc3F lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":48082
  },
  {
    "COADD_ID":"CO-ADD:0319555",
    "INHIB_AVE":12.47,
    "SMILES":"c12c(nnc(SCc(cccc3C(F)(F)F)c3)n1)c(c4n2C(C)C)cccc4",
    "HIT":0.0,
    "question":"Can c12c(nnc(SCc(cccc3C(F)(F)F)c3)n1)c(c4n2C(C)C)cccc4 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":11532
  },
  {
    "COADD_ID":"CO-ADD:0289120",
    "INHIB_AVE":-2.91,
    "SMILES":"c(C(=O)Nc1cccc(OC)c1)(nnc2C(OCC)=O)s2",
    "HIT":0.0,
    "question":"Is c(C(=O)Nc1cccc(OC)c1)(nnc2C(OCC)=O)s2 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":67018
  },
  {
    "COADD_ID":"CO-ADD:0136605",
    "INHIB_AVE":6.47,
    "SMILES":"N1(C(CC)C1)P(Oc2ccc(cc2)Cl)(N3C(CC)C3)=O",
    "HIT":0.0,
    "question":"Does N1(C(CC)C1)P(Oc2ccc(cc2)Cl)(N3C(CC)C3)=O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":29252
  },
  {
    "COADD_ID":"CO-ADD:0231843",
    "INHIB_AVE":10.09,
    "SMILES":"c1(c2ccccc2C)oc(c3n1)ccc(c3)\\N=C\\c4ccccc4O",
    "HIT":0.0,
    "question":"Can c1(c2ccccc2C)oc(c3n1)ccc(c3)\\N=C\\c4ccccc4O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":16769
  },
  {
    "COADD_ID":"CO-ADD:0249897",
    "INHIB_AVE":4.78,
    "SMILES":"c1(nnc(COc2ccccc2)s1)NC(=O)c(cc3)ccc3C(C)(C)C",
    "HIT":0.0,
    "question":"Can c1(nnc(COc2ccccc2)s1)NC(=O)c(cc3)ccc3C(C)(C)C act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":36654
  },
  {
    "COADD_ID":"CO-ADD:0215608",
    "INHIB_AVE":8.11,
    "SMILES":"S(c1ccccc1)(=O)(=O)N(c2ccc(c(Cl)c2)Cl)CC(=O)N\\N=C\\c(c(OC)ccc3[N+](=O)[O-])c3",
    "HIT":0.0,
    "question":"Can exposure to S(c1ccccc1)(=O)(=O)N(c2ccc(c(Cl)c2)Cl)CC(=O)N\\N=C\\c(c(OC)ccc3[N+](=O)[O-])c3 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":22818
  },
  {
    "COADD_ID":"CO-ADD:0277826",
    "INHIB_AVE":16.74,
    "SMILES":"C(=N\\c1ccccc1)(\/S\\C(\\C2=O)=C\\c3ccccc3Cl)\\N2C4CCCC4",
    "HIT":0.0,
    "question":"Is C(=N\\c1ccccc1)(\/S\\C(\\C2=O)=C\\c3ccccc3Cl)\\N2C4CCCC4 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":5539
  },
  {
    "COADD_ID":"CO-ADD:0232552",
    "INHIB_AVE":10.52,
    "SMILES":"N1(c2ccc(cc2Cl)Cl)C(=O)C(CC1=O)SCC(=O)Nc(cc3)ccc3Cl",
    "HIT":0.0,
    "question":"Does N1(c2ccc(cc2Cl)Cl)C(=O)C(CC1=O)SCC(=O)Nc(cc3)ccc3Cl demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":15682
  },
  {
    "COADD_ID":"CO-ADD:0242224",
    "INHIB_AVE":1.48,
    "SMILES":"N(=C\\c(cc1)cc(c1OC(C)=O)OC)\/N(c2ccccc2)c3ccccc3",
    "HIT":0.0,
    "question":"Does the proposed molecule N(=C\\c(cc1)cc(c1OC(C)=O)OC)\/N(c2ccccc2)c3ccccc3 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":51379
  },
  {
    "COADD_ID":"CO-ADD:0157623",
    "INHIB_AVE":14.59,
    "SMILES":"O=C(C1=CC=CO1)NC2=C(C(OCC)=O)SC3=C2C(C4=CC=CC=C4)=CC(C5=CC=CC=C5)=N3",
    "HIT":0.0,
    "question":"Does O=C(C1=CC=CO1)NC2=C(C(OCC)=O)SC3=C2C(C4=CC=CC=C4)=CC(C5=CC=CC=C5)=N3 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":8131
  },
  {
    "COADD_ID":"CO-ADD:0235287",
    "INHIB_AVE":4.8,
    "SMILES":"C(=O)(c1ccc(cc1)Br)Oc2cc(ccc2OC(=O)c3ccc(cc3)Br)\\C=N\\NC(c4ccccc4)=O",
    "HIT":0.0,
    "question":"Is C(=O)(c1ccc(cc1)Br)Oc2cc(ccc2OC(=O)c3ccc(cc3)Br)\\C=N\\NC(c4ccccc4)=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":36527
  },
  {
    "COADD_ID":"CO-ADD:0286290",
    "INHIB_AVE":12.98,
    "SMILES":"c1(NC(COC(CSc2nc(C)cc(C)n2)=O)=O)n(c3ccccc3)ncc1C(OCC)=O",
    "HIT":0.0,
    "question":"Does treatment with c1(NC(COC(CSc2nc(C)cc(C)n2)=O)=O)n(c3ccccc3)ncc1C(OCC)=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":10591
  },
  {
    "COADD_ID":"CO-ADD:0234833",
    "INHIB_AVE":6.49,
    "SMILES":"[N+](=O)([O-])c1ccccc1OCC(=O)N\\N=C\\c(c2)c(ccc2[N+](=O)[O-])OC(c3ccccc3)=O",
    "HIT":0.0,
    "question":"Does [N+](=O)([O-])c1ccccc1OCC(=O)N\\N=C\\c(c2)c(ccc2[N+](=O)[O-])OC(c3ccccc3)=O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":29150
  },
  {
    "COADD_ID":"CO-ADD:0221456",
    "INHIB_AVE":10.02,
    "SMILES":"S(=O)(=O)(Nc(cc1)ccc1OCCCC)c2cccc3c2cccc3S(=O)(=O)Nc(cc4)ccc4OCCCC",
    "HIT":0.0,
    "question":"Does treatment with S(=O)(=O)(Nc(cc1)ccc1OCCCC)c2cccc3c2cccc3S(=O)(=O)Nc(cc4)ccc4OCCCC result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":16954
  },
  {
    "COADD_ID":"CO-ADD:0328713",
    "INHIB_AVE":7.09,
    "SMILES":"N1(C(=O)c2ccc(cc2)F)N3C(=NC1=S)C=CC=C3",
    "HIT":0.0,
    "question":"Can N1(C(=O)c2ccc(cc2)F)N3C(=NC1=S)C=CC=C3 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":26641
  },
  {
    "COADD_ID":"CO-ADD:0229333",
    "INHIB_AVE":3.83,
    "SMILES":"S(NCCNC(=O)c1nonc1N)(c2ccccc2)(=O)=O",
    "HIT":0.0,
    "question":"Does S(NCCNC(=O)c1nonc1N)(c2ccccc2)(=O)=O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":40928
  },
  {
    "COADD_ID":"CO-ADD:0237434",
    "INHIB_AVE":10.13,
    "SMILES":"CCOC(=O)c1noc(N)c1c2ccccc2",
    "HIT":0.0,
    "question":"Can CCOC(=O)c1noc(N)c1c2ccccc2 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":16678
  },
  {
    "COADD_ID":"CO-ADD:0304196",
    "INHIB_AVE":2.26,
    "SMILES":"C(=O)(C(NCCOC)=O)Nc1ccccc1C",
    "HIT":0.0,
    "question":"Does C(=O)(C(NCCOC)=O)Nc1ccccc1C demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":47940
  },
  {
    "COADD_ID":"CO-ADD:0229903",
    "INHIB_AVE":21.47,
    "SMILES":"c1(ccc(cc1Cl)Cl)C(=O)Nc(cc2)ccc2C(N)=O",
    "HIT":0.0,
    "question":"Can c1(ccc(cc1Cl)Cl)C(=O)Nc(cc2)ccc2C(N)=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":2132
  },
  {
    "COADD_ID":"CO-ADD:0291913",
    "INHIB_AVE":0.74,
    "SMILES":"N1(C2c3ccc(cc3)C)C(S\\C(=C\/c(ccc4c5ccc(cc5[N+](=O)[O-])C)o4)\\C1=O)=NC(C)=C2C(OCC)=O",
    "HIT":0.0,
    "question":"Can N1(C2c3ccc(cc3)C)C(S\\C(=C\/c(ccc4c5ccc(cc5[N+](=O)[O-])C)o4)\\C1=O)=NC(C)=C2C(OCC)=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":54542
  },
  {
    "COADD_ID":"CO-ADD:0311779",
    "INHIB_AVE":6.78,
    "SMILES":"C(=O)(C(O)(c1ccc(cc1)C)c2ccc(cc2)C)NN(C(CC)c3ccc(cc3)C)C(c4ccccc4)=O",
    "HIT":0.0,
    "question":"Does the proposed molecule C(=O)(C(O)(c1ccc(cc1)C)c2ccc(cc2)C)NN(C(CC)c3ccc(cc3)C)C(c4ccccc4)=O exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":27918
  },
  {
    "COADD_ID":"CO-ADD:0320837",
    "INHIB_AVE":-0.14,
    "SMILES":"C(c1c(N2Cc3ccccc3F)cccc1)(C2=O)(NC(=O)c(c45)c(c(C)s4)C)N5",
    "HIT":0.0,
    "question":"Can C(c1c(N2Cc3ccccc3F)cccc1)(C2=O)(NC(=O)c(c45)c(c(C)s4)C)N5 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":58024
  },
  {
    "COADD_ID":"CO-ADD:0283784",
    "INHIB_AVE":-8.79,
    "SMILES":"c1(c2nc(cccc3)c3n1)\\C(=N\/C4CCCCC4)\\c5c2cccc5",
    "HIT":0.0,
    "question":"Does c1(c2nc(cccc3)c3n1)\\C(=N\/C4CCCCC4)\\c5c2cccc5 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":77608
  },
  {
    "COADD_ID":"CO-ADD:0242470",
    "INHIB_AVE":1.52,
    "SMILES":"c1(SCC(=O)NC(C)c2ccccc2)sc3c(ccc(c3)\\N=C\\c(cc(Br)cc4Br)c4O)n1",
    "HIT":0.0,
    "question":"Can c1(SCC(=O)NC(C)c2ccccc2)sc3c(ccc(c3)\\N=C\\c(cc(Br)cc4Br)c4O)n1 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":51193
  },
  {
    "COADD_ID":"CO-ADD:0303313",
    "INHIB_AVE":-6.75,
    "SMILES":"C1(C#N)=C(SCc2cccc(cccc3)c23)NC(=O)CC1c4ccccc4C",
    "HIT":0.0,
    "question":"Can C1(C#N)=C(SCc2cccc(cccc3)c23)NC(=O)CC1c4ccccc4C effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":74958
  },
  {
    "COADD_ID":"CO-ADD:0320010",
    "INHIB_AVE":4.34,
    "SMILES":"C1([N+](=O)[O-])=C(C)NC(C(C(O)=O)=C1C)=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C1([N+](=O)[O-])=C(C)NC(C(C(O)=O)=C1C)=O?",
    "answer":"No",
    "_id":38612
  },
  {
    "COADD_ID":"CO-ADD:0253333",
    "INHIB_AVE":-3.99,
    "SMILES":"c1(N\\N=C\/c(cc2)ccc2N(C)C)nc(C)cc(C)n1",
    "HIT":0.0,
    "question":"Does the proposed molecule c1(N\\N=C\/c(cc2)ccc2N(C)C)nc(C)cc(C)n1 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":69732
  },
  {
    "COADD_ID":"CO-ADD:0241480",
    "INHIB_AVE":3.96,
    "SMILES":"c1(Nc(cccc2C(F)(F)F)c2)nc(N\\N=C\\c3ccc(cc3Cl)Cl)nc(NC)n1.Cl",
    "HIT":0.0,
    "question":"Is c1(Nc(cccc2C(F)(F)F)c2)nc(N\\N=C\\c3ccc(cc3Cl)Cl)nc(NC)n1.Cl effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":40355
  },
  {
    "COADD_ID":"CO-ADD:0240654",
    "INHIB_AVE":16.34,
    "SMILES":"n1(nnc(C(OCC)=O)c1CN(CC2)CCC2C(OCC)=O)c3nonc3N",
    "HIT":0.0,
    "question":"Does n1(nnc(C(OCC)=O)c1CN(CC2)CCC2C(OCC)=O)c3nonc3N show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":5969
  },
  {
    "COADD_ID":"CO-ADD:0149036",
    "INHIB_AVE":8.97,
    "SMILES":"c1c(c(nc(c(ccnc2)c2)o3)n3)ccc4c1OCO4",
    "HIT":0.0,
    "question":"Is c1c(c(nc(c(ccnc2)c2)o3)n3)ccc4c1OCO4 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":20002
  },
  {
    "COADD_ID":"CO-ADD:0220439",
    "INHIB_AVE":-4.65,
    "SMILES":"C(=O)(C(c1ccccc1)c2ccccc2)NCC(=O)N\\N=C\\c(cc3)ccc3N(CC)CC",
    "HIT":0.0,
    "question":"Can exposure to C(=O)(C(c1ccccc1)c2ccccc2)NCC(=O)N\\N=C\\c(cc3)ccc3N(CC)CC lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":71141
  },
  {
    "COADD_ID":"CO-ADD:0292375",
    "INHIB_AVE":-3.02,
    "SMILES":"C1(\\N=C(\\c2c(N3CN4CCCC(C)C4)cccc2)\/C3=O)=C(C)N(N(c5ccccc5)C1=O)C",
    "HIT":0.0,
    "question":"Does C1(\\N=C(\\c2c(N3CN4CCCC(C)C4)cccc2)\/C3=O)=C(C)N(N(c5ccccc5)C1=O)C demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":67299
  },
  {
    "COADD_ID":"CO-ADD:0155643",
    "INHIB_AVE":8.06,
    "SMILES":"O=C(C1=C2C=CC(OC(C=C3)=CC=C3N)=C1)N(C(C=C4)=CC=C4C(O)=O)C2=O",
    "HIT":0.0,
    "question":"Can O=C(C1=C2C=CC(OC(C=C3)=CC=C3N)=C1)N(C(C=C4)=CC=C4C(O)=O)C2=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":22976
  },
  {
    "COADD_ID":"CO-ADD:0285350",
    "INHIB_AVE":-2.85,
    "SMILES":"C(SC\\C(\\CS1)=N\\NCCCCCCCCCCCCCCCCC)(SC(S2)=S)=C12",
    "HIT":0.0,
    "question":"Does C(SC\\C(\\CS1)=N\\NCCCCCCCCCCCCCCCCC)(SC(S2)=S)=C12 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":66820
  },
  {
    "COADD_ID":"CO-ADD:0240372",
    "INHIB_AVE":-0.95,
    "SMILES":"C1(O)(C(F)F)CC(=O)c(c2O1)ccc(OC)c2",
    "HIT":0.0,
    "question":"Is C1(O)(C(F)F)CC(=O)c(c2O1)ccc(OC)c2 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":60955
  },
  {
    "COADD_ID":"CO-ADD:0214908",
    "INHIB_AVE":11.37,
    "SMILES":"N1(c2cccc(Cl)c2)C(=O)\\C(\\C(C)=N1)=C\\Nc(cc3)ccc3S(=O)(=O)Nc(cc4)ccc4Br",
    "HIT":0.0,
    "question":"Can N1(c2cccc(Cl)c2)C(=O)\\C(\\C(C)=N1)=C\\Nc(cc3)ccc3S(=O)(=O)Nc(cc4)ccc4Br act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":13743
  },
  {
    "COADD_ID":"CO-ADD:0242889",
    "INHIB_AVE":10.78,
    "SMILES":"C(=O)(C(NCCCn(ccn1)c1)=O)Nc2cc(C)ccc2C",
    "HIT":0.0,
    "question":"Is C(=O)(C(NCCCn(ccn1)c1)=O)Nc2cc(C)ccc2C effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":15033
  },
  {
    "COADD_ID":"CO-ADD:0321164",
    "INHIB_AVE":17.9,
    "SMILES":"C(\/S1)(\\Oc2c1cc(cc2C)C)=C(\/C(OC)=O)\\C(F)(F)F",
    "HIT":0.0,
    "question":"Can exposure to C(\/S1)(\\Oc2c1cc(cc2C)C)=C(\/C(OC)=O)\\C(F)(F)F lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":4392
  },
  {
    "COADD_ID":"CO-ADD:0232286",
    "INHIB_AVE":-0.81,
    "SMILES":"C1(C(OC)=O)=C(C)NC(NC1c2cc(OC)ccc2OC)=O",
    "HIT":0.0,
    "question":"Can exposure to C1(C(OC)=O)=C(C)NC(NC1c2cc(OC)ccc2OC)=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":60450
  },
  {
    "COADD_ID":"CO-ADD:0321130",
    "INHIB_AVE":12.49,
    "SMILES":"C1(=O)\\C(\\CCc2c1cccc2OC)=C\\c3ccccc3",
    "HIT":0.0,
    "question":"Can C1(=O)\\C(\\CCc2c1cccc2OC)=C\\c3ccccc3 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":11494
  },
  {
    "COADD_ID":"CO-ADD:0242558",
    "INHIB_AVE":7.89,
    "SMILES":"C1(=Cc2c(OC1=O)ccc(OC)c2)c3csc(\\N=C\\c4ccccc4O)n3",
    "HIT":0.0,
    "question":"Does C1(=Cc2c(OC1=O)ccc(OC)c2)c3csc(\\N=C\\c4ccccc4O)n3 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":23624
  },
  {
    "COADD_ID":"CO-ADD:0235770",
    "INHIB_AVE":-17.47,
    "SMILES":"N(\/c1ccc(cc1C#N)Br)=C(\/CCC2)\\N2C.Cl",
    "HIT":0.0,
    "question":"Can N(\/c1ccc(cc1C#N)Br)=C(\/CCC2)\\N2C.Cl act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":81821
  },
  {
    "COADD_ID":"CO-ADD:0247659",
    "INHIB_AVE":-2.33,
    "SMILES":"[N+](=O)([O-])c1ccc(cc1)OC(c2ccccc2)C(=O)N\\N=C(\/C)\\C=C\\C3C(C)(C)CCC=C3C",
    "HIT":0.0,
    "question":"Is [N+](=O)([O-])c1ccc(cc1)OC(c2ccccc2)C(=O)N\\N=C(\/C)\\C=C\\C3C(C)(C)CCC=C3C capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":65353
  },
  {
    "COADD_ID":"CO-ADD:0287876",
    "INHIB_AVE":-4.19,
    "SMILES":"C(=C\/c1cccc(c1)OCc2ccccc2F)(\/C(=O)N(C)C(N3C)=O)\\C3=O",
    "HIT":0.0,
    "question":"Does treatment with C(=C\/c1cccc(c1)OCc2ccccc2F)(\/C(=O)N(C)C(N3C)=O)\\C3=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":70192
  },
  {
    "COADD_ID":"CO-ADD:0301950",
    "INHIB_AVE":-11.95,
    "SMILES":"N1(CN(CC2)CCN2C(c3ccccc3)c4ccccc4)c(cccc5)c5\\C(=N\\NC(=O)c6ccc(cc6)C)\\C1=O",
    "HIT":0.0,
    "question":"Does the proposed molecule N1(CN(CC2)CCN2C(c3ccccc3)c4ccccc4)c(cccc5)c5\\C(=N\\NC(=O)c6ccc(cc6)C)\\C1=O exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":79997
  },
  {
    "COADD_ID":"CO-ADD:0256514",
    "INHIB_AVE":3.92,
    "SMILES":"c(NC(=O)c(cc1)ccc1C(C)(C)C)(sc(c2c3ccccc3)c4ccccc4)n2.Cl",
    "HIT":0.0,
    "question":"Is c(NC(=O)c(cc1)ccc1C(C)(C)C)(sc(c2c3ccccc3)c4ccccc4)n2.Cl effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":40519
  },
  {
    "COADD_ID":"CO-ADD:0155073",
    "INHIB_AVE":-13.01,
    "SMILES":"O=C1NC(C(CCCCC(OCC)=O)=O)=C(CSC2=NC(N)=C3N=CNC3=N2)N1",
    "HIT":0.0,
    "question":"Does treatment with O=C1NC(C(CCCCC(OCC)=O)=O)=C(CSC2=NC(N)=C3N=CNC3=N2)N1 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":80527
  },
  {
    "COADD_ID":"CO-ADD:0256298",
    "INHIB_AVE":7.67,
    "SMILES":"c(C#N)(c(N)n(n1)CCO)c1\\C(\\C#N)=C\\c(cn(n2)Cc3ccc(cc3Cl)Cl)c2c4ccccc4",
    "HIT":0.0,
    "question":"Can c(C#N)(c(N)n(n1)CCO)c1\\C(\\C#N)=C\\c(cn(n2)Cc3ccc(cc3Cl)Cl)c2c4ccccc4 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":24428
  },
  {
    "COADD_ID":"CO-ADD:0259892",
    "INHIB_AVE":12.92,
    "SMILES":"C1(SC\\C(\\CS2)=C(\\C#N)\/C#N)=C2SC(=S)S1",
    "HIT":0.0,
    "question":"Can exposure to C1(SC\\C(\\CS2)=C(\\C#N)\/C#N)=C2SC(=S)S1 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":10715
  },
  {
    "COADD_ID":"CO-ADD:0304107",
    "INHIB_AVE":12.21,
    "SMILES":"N1C(=O)C(SC1c2ccc(cc2)F)C",
    "HIT":0.0,
    "question":"Does the proposed molecule N1C(=O)C(SC1c2ccc(cc2)F)C exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":12059
  },
  {
    "COADD_ID":"CO-ADD:0237049",
    "INHIB_AVE":-7.37,
    "SMILES":"Clc1ccc(CCNc2cc(nc3ncnn23)c4ccccc4)cc1",
    "HIT":0.0,
    "question":"Does Clc1ccc(CCNc2cc(nc3ncnn23)c4ccccc4)cc1 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":75880
  },
  {
    "COADD_ID":"CO-ADD:0302762",
    "INHIB_AVE":-1.55,
    "SMILES":"c1(nonc1N)\\C(\\N)=N\\OCc2ccc(cc2Cl)F",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(nonc1N)\\C(\\N)=N\\OCc2ccc(cc2Cl)F?",
    "answer":"No",
    "_id":62903
  },
  {
    "COADD_ID":"CO-ADD:0154452",
    "INHIB_AVE":-7.67,
    "SMILES":"O=C(NNC(CC)CC)C1=CC(C=CC=C2)=C2N1C",
    "HIT":0.0,
    "question":"Can O=C(NNC(CC)CC)C1=CC(C=CC=C2)=C2N1C act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":76292
  },
  {
    "COADD_ID":"CO-ADD:0285995",
    "INHIB_AVE":0.7,
    "SMILES":"ClC1=CC(OC\/C=N\/NC(C2=CC=NC=C2)=O)=CC=C1",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound ClC1=CC(OC\/C=N\/NC(C2=CC=NC=C2)=O)=CC=C1?",
    "answer":"No",
    "_id":54714
  },
  {
    "COADD_ID":"CO-ADD:0328542",
    "INHIB_AVE":7.06,
    "SMILES":"c1(c(cc(I)cc2[N+](=O)[O-])c2)nnc(c(cc3)ccc3C(OCC)=O)o1",
    "HIT":0.0,
    "question":"Is c1(c(cc(I)cc2[N+](=O)[O-])c2)nnc(c(cc3)ccc3C(OCC)=O)o1 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":26732
  },
  {
    "COADD_ID":"CO-ADD:0161883",
    "INHIB_AVE":2.82,
    "SMILES":"c(\\C=N\\NC(COc(cc1)ccc1Cl)=O)(cc(Br)cc2Br)c2O",
    "HIT":0.0,
    "question":"Does c(\\C=N\\NC(COc(cc1)ccc1Cl)=O)(cc(Br)cc2Br)c2O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":45444
  },
  {
    "COADD_ID":"CO-ADD:0283026",
    "INHIB_AVE":0.78,
    "SMILES":"N1(C(CC(C)(C)CC2=O)=C2C(C(C#N)=C1N)c(cc3)ccc3[N+](=O)[O-])c4sc(c5c4C(OC)=O)CCCC5",
    "HIT":0.0,
    "question":"Is N1(C(CC(C)(C)CC2=O)=C2C(C(C#N)=C1N)c(cc3)ccc3[N+](=O)[O-])c4sc(c5c4C(OC)=O)CCCC5 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":54379
  },
  {
    "COADD_ID":"CO-ADD:0161778",
    "INHIB_AVE":2.78,
    "SMILES":"C(CNc1ccccc1)(=O)N\\N=C\/c(cc2)ccc2F",
    "HIT":0.0,
    "question":"Can C(CNc1ccccc1)(=O)N\\N=C\/c(cc2)ccc2F act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":45637
  },
  {
    "COADD_ID":"CO-ADD:0231321",
    "INHIB_AVE":-4.83,
    "SMILES":"S(=O)(=O)(c1ccc(cc1)C)Oc2ccccc2\\C=N\/c3cccc(C)c3",
    "HIT":0.0,
    "question":"Is S(=O)(=O)(c1ccc(cc1)C)Oc2ccccc2\\C=N\/c3cccc(C)c3 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":71523
  },
  {
    "COADD_ID":"CO-ADD:0332117",
    "INHIB_AVE":15.54,
    "SMILES":"C1(C(=O)NCc2ccco2)=Cc(cc(Cl)cc3Cl)c3OC1=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C1(C(=O)NCc2ccco2)=Cc(cc(Cl)cc3Cl)c3OC1=O?",
    "answer":"No",
    "_id":6888
  },
  {
    "COADD_ID":"CO-ADD:0215260",
    "INHIB_AVE":-5.19,
    "SMILES":"C1(NC(CCc2ccccc2)=O)=C(C)N(N(c3ccccc3)C1=O)C",
    "HIT":0.0,
    "question":"Does treatment with C1(NC(CCc2ccccc2)=O)=C(C)N(N(c3ccccc3)C1=O)C result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":72239
  },
  {
    "COADD_ID":"CO-ADD:0277340",
    "INHIB_AVE":7.35,
    "SMILES":"N1(c2ccccc2)C(C(SC1=S)(C)C)\\[N+](\\[O-])=C\\c(cc3)ccc3SC",
    "HIT":0.0,
    "question":"Does N1(c2ccccc2)C(C(SC1=S)(C)C)\\[N+](\\[O-])=C\\c(cc3)ccc3SC demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":25685
  },
  {
    "COADD_ID":"CO-ADD:0284206",
    "INHIB_AVE":-14.25,
    "SMILES":"S(c1ccccc1)(=O)(=O)N2CCC(CC2)C(=O)N\\N=C(\\c3c(N4)cccc3)\/C4=O",
    "HIT":0.0,
    "question":"Does S(c1ccccc1)(=O)(=O)N2CCC(CC2)C(=O)N\\N=C(\\c3c(N4)cccc3)\/C4=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":81057
  },
  {
    "COADD_ID":"CO-ADD:0226692",
    "INHIB_AVE":2.95,
    "SMILES":"N1(c2c(ccc(c2)C(=O)NC(C)CC)C(N3CCC(C)C)=O)C3=NN(CC#N)C1=O",
    "HIT":0.0,
    "question":"Can N1(c2c(ccc(c2)C(=O)NC(C)CC)C(N3CCC(C)C)=O)C3=NN(CC#N)C1=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":44877
  },
  {
    "COADD_ID":"CO-ADD:0227797",
    "INHIB_AVE":5.01,
    "SMILES":"C12=C(c3c(cccc3)CC14CCCCC4)N=C(N(C)C2=O)SCC",
    "HIT":0.0,
    "question":"Can C12=C(c3c(cccc3)CC14CCCCC4)N=C(N(C)C2=O)SCC act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":35574
  },
  {
    "COADD_ID":"CO-ADD:0218517",
    "INHIB_AVE":-0.57,
    "SMILES":"C(=O)(N\\N=C\\c(cc1)ccc1F)C(=O)Nc2ccccc2CC",
    "HIT":0.0,
    "question":"Does treatment with C(=O)(N\\N=C\\c(cc1)ccc1F)C(=O)Nc2ccccc2CC result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":59604
  },
  {
    "COADD_ID":"CO-ADD:0158568",
    "INHIB_AVE":4.12,
    "SMILES":"O=C(N\/N=C\/C1=CC(I)=CC=C1O)C2=CC=CC=N2",
    "HIT":0.0,
    "question":"Does the proposed molecule O=C(N\/N=C\/C1=CC(I)=CC=C1O)C2=CC=CC=N2 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":39641
  },
  {
    "COADD_ID":"CO-ADD:0135850",
    "INHIB_AVE":-12.46,
    "SMILES":"O=C1c2c(cccc2)C(C1C(C(C)(C)C)=N3)=N3",
    "HIT":0.0,
    "question":"Can exposure to O=C1c2c(cccc2)C(C1C(C(C)(C)C)=N3)=N3 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":80278
  },
  {
    "COADD_ID":"CO-ADD:0236913",
    "INHIB_AVE":16.46,
    "SMILES":"N(\\C(=N\/c1cccc(C)c1)\\C2(N3c4cccc(C)c4)CCCCC2)=C3SC",
    "HIT":0.0,
    "question":"Can exposure to N(\\C(=N\/c1cccc(C)c1)\\C2(N3c4cccc(C)c4)CCCCC2)=C3SC lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":5852
  },
  {
    "COADD_ID":"CO-ADD:0160019",
    "INHIB_AVE":11.07,
    "SMILES":"CCN(CC)C1=NC(N\/N=C\/C2=CC=C3OCOC3=C2)=NC(NC4=CC=CC=C4)=N1",
    "HIT":0.0,
    "question":"Can CCN(CC)C1=NC(N\/N=C\/C2=CC=C3OCOC3=C2)=NC(NC4=CC=CC=C4)=N1 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":14380
  },
  {
    "COADD_ID":"CO-ADD:0327239",
    "INHIB_AVE":0.8,
    "SMILES":"N1(Cc2ccco2)C(=O)\\C(\\SC1=S)=C\\c(cc3)ccc3OCc4ccccc4F",
    "HIT":0.0,
    "question":"Does N1(Cc2ccco2)C(=O)\\C(\\SC1=S)=C\\c(cc3)ccc3OCc4ccccc4F demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":54288
  },
  {
    "COADD_ID":"CO-ADD:0258801",
    "INHIB_AVE":-6.08,
    "SMILES":"c1(c(cccc2OC)c23)c(CC(C)S1)c(n3)C",
    "HIT":0.0,
    "question":"Is c1(c(cccc2OC)c23)c(CC(C)S1)c(n3)C capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":73882
  },
  {
    "COADD_ID":"CO-ADD:0254828",
    "INHIB_AVE":8.61,
    "SMILES":"c1(C2c3c(cccc3Cl)F)c([nH]nc1C(C)(C)C)OC(N)=C2C#N",
    "HIT":0.0,
    "question":"Is c1(C2c3c(cccc3Cl)F)c([nH]nc1C(C)(C)C)OC(N)=C2C#N capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":21122
  },
  {
    "COADD_ID":"CO-ADD:0240555",
    "INHIB_AVE":3.99,
    "SMILES":"N(c1sccn1)(C2c(cccc3[N+](=O)[O-])c3)C(=O)C(=C2C(=O)c4ccc(cc4)Cl)O",
    "HIT":0.0,
    "question":"Can exposure to N(c1sccn1)(C2c(cccc3[N+](=O)[O-])c3)C(=O)C(=C2C(=O)c4ccc(cc4)Cl)O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":40213
  },
  {
    "COADD_ID":"CO-ADD:0307244",
    "INHIB_AVE":8.48,
    "SMILES":"c1(C(N)=O)c(Cl)c(Cl)c(nc1Cl)Cl",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(C(N)=O)c(Cl)c(Cl)c(nc1Cl)Cl?",
    "answer":"No",
    "_id":21526
  },
  {
    "COADD_ID":"CO-ADD:0303101",
    "INHIB_AVE":6.84,
    "SMILES":"n1(c(cc2)ccc2C(N)=O)nnnc1SCC(=O)Nc3ccccc3CC",
    "HIT":0.0,
    "question":"Can n1(c(cc2)ccc2C(N)=O)nnnc1SCC(=O)Nc3ccccc3CC effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":27648
  },
  {
    "COADD_ID":"CO-ADD:0259473",
    "INHIB_AVE":7.37,
    "SMILES":"N(\\C(=C\/c(ccc1c2ccc(cc2Cl)Cl)o1)\\C(O3)=O)=C3c(ccc(c4[N+](=O)[O-])Cl)c4",
    "HIT":0.0,
    "question":"Can N(\\C(=C\/c(ccc1c2ccc(cc2Cl)Cl)o1)\\C(O3)=O)=C3c(ccc(c4[N+](=O)[O-])Cl)c4 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":25591
  },
  {
    "COADD_ID":"CO-ADD:0320572",
    "INHIB_AVE":4.39,
    "SMILES":"N1(C(CCl)=O)c2c(cccc2)Sc(ccc(c3)C(F)(F)F)c13",
    "HIT":0.0,
    "question":"Does N1(C(CCl)=O)c2c(cccc2)Sc(ccc(c3)C(F)(F)F)c13 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":38401
  },
  {
    "COADD_ID":"CO-ADD:0253376",
    "INHIB_AVE":8.73,
    "SMILES":"C(=O)(N\\N=C\\c1ccccc1F)C(=O)N2CCCCCC2",
    "HIT":0.0,
    "question":"Is C(=O)(N\\N=C\\c1ccccc1F)C(=O)N2CCCCCC2 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":20771
  },
  {
    "COADD_ID":"CO-ADD:0312586",
    "INHIB_AVE":-6.67,
    "SMILES":"C1=C[C@@](CN2C(C)=O)([C@]([C@@]3(O[C@H]4C=C3)C2)([C@]45C(OC)=O)C(OC)=O)O[C@H]15",
    "HIT":0.0,
    "question":"Can C1=C[C@@](CN2C(C)=O)([C@]([C@@]3(O[C@H]4C=C3)C2)([C@]45C(OC)=O)C(OC)=O)O[C@H]15 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":74845
  },
  {
    "COADD_ID":"CO-ADD:0312330",
    "INHIB_AVE":8.52,
    "SMILES":"c1(C(=O)N(C)C(N2C)=O)c2nc3n1cc(n3c4ccc(cc4)OCCCCCCCC)c5ccc(cc5)Br",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(C(=O)N(C)C(N2C)=O)c2nc3n1cc(n3c4ccc(cc4)OCCCCCCCC)c5ccc(cc5)Br?",
    "answer":"No",
    "_id":21381
  },
  {
    "COADD_ID":"CO-ADD:0331267",
    "INHIB_AVE":2.13,
    "SMILES":"n(c(Cl)nc(n1)OC)c1N",
    "HIT":0.0,
    "question":"Can exposure to n(c(Cl)nc(n1)OC)c1N lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":48477
  },
  {
    "COADD_ID":"CO-ADD:0215517",
    "INHIB_AVE":18.2,
    "SMILES":"C(N(C)C)(=S)Oc(cc1)ccc1C(=O)Nc(cc2)ccc2F",
    "HIT":0.0,
    "question":"Can C(N(C)C)(=S)Oc(cc1)ccc1C(=O)Nc(cc2)ccc2F effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":4132
  },
  {
    "COADD_ID":"CO-ADD:0327371",
    "INHIB_AVE":-0.26,
    "SMILES":"C12=C(CC(c3cccs3)CC1=O)Nc(c4NC2C5=CC(c6c(cccc6)O5)=O)cccc4",
    "HIT":0.0,
    "question":"Does the proposed molecule C12=C(CC(c3cccs3)CC1=O)Nc(c4NC2C5=CC(c6c(cccc6)O5)=O)cccc4 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":58455
  },
  {
    "COADD_ID":"CO-ADD:0311309",
    "INHIB_AVE":-11.46,
    "SMILES":"S(=O)(=O)(N(CC1)CCN1c2ccccc2)c3c(OC)cc(c(C)c3)C",
    "HIT":0.0,
    "question":"Does S(=O)(=O)(N(CC1)CCN1c2ccccc2)c3c(OC)cc(c(C)c3)C show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":79685
  },
  {
    "COADD_ID":"CO-ADD:0290627",
    "INHIB_AVE":14.38,
    "SMILES":"C(C(C)=N)(C1c2ccccc2)=C(O)C(N1C)=O",
    "HIT":0.0,
    "question":"Does C(C(C)=N)(C1c2ccccc2)=C(O)C(N1C)=O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":8451
  },
  {
    "COADD_ID":"CO-ADD:0248172",
    "INHIB_AVE":-2.54,
    "SMILES":"N1(c(cc2)ccc2C(C)=O)C(=O)C3C(C4C5(CC5)C3C=C4)C1=O",
    "HIT":0.0,
    "question":"Can exposure to N1(c(cc2)ccc2C(C)=O)C(=O)C3C(C4C5(CC5)C3C=C4)C1=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":65939
  },
  {
    "COADD_ID":"CO-ADD:0232443",
    "INHIB_AVE":10.5,
    "SMILES":"C(=O)(c1cccc(OC)c1)Oc2ccc(cc2OC)\\C=N\\NC(=O)c(c3)cc(cn3)Br",
    "HIT":0.0,
    "question":"Does C(=O)(c1cccc(OC)c1)Oc2ccc(cc2OC)\\C=N\\NC(=O)c(c3)cc(cn3)Br demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":15728
  },
  {
    "COADD_ID":"CO-ADD:0329123",
    "INHIB_AVE":-3.5,
    "SMILES":"N#CCc(cc1)ccc1NC(COc(cc2)ccc2Cl)=O",
    "HIT":0.0,
    "question":"Does N#CCc(cc1)ccc1NC(COc(cc2)ccc2Cl)=O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":68523
  },
  {
    "COADD_ID":"CO-ADD:0312119",
    "INHIB_AVE":2.24,
    "SMILES":"c12c(C(N(C)C(=O)N1C)=O)n(c(O)n2)Cc3ccc(cc3Cl)Cl",
    "HIT":0.0,
    "question":"Does c12c(C(N(C)C(=O)N1C)=O)n(c(O)n2)Cc3ccc(cc3Cl)Cl show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":48070
  },
  {
    "COADD_ID":"CO-ADD:0278256",
    "INHIB_AVE":-2.84,
    "SMILES":"n1(c2c(n3)cccc2)c3S\\C(=C\/c(ccc(c4OC)OCc5ccccc5F)c4)\\C1=O",
    "HIT":0.0,
    "question":"Is n1(c2c(n3)cccc2)c3S\\C(=C\/c(ccc(c4OC)OCc5ccccc5F)c4)\\C1=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":66807
  },
  {
    "COADD_ID":"CO-ADD:0284607",
    "INHIB_AVE":-4.06,
    "SMILES":"c(c1ccccc1Cl)([nH]nc2c3cc(Cl)ccc3O)c2",
    "HIT":0.0,
    "question":"Does the proposed molecule c(c1ccccc1Cl)([nH]nc2c3cc(Cl)ccc3O)c2 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":69901
  },
  {
    "COADD_ID":"CO-ADD:0136557",
    "INHIB_AVE":-1.88,
    "SMILES":"c1c(C)cc(c(ccc(C(=O)C=CC2=O)c23)c3n4C)c4c1",
    "HIT":0.0,
    "question":"Can c1c(C)cc(c(ccc(C(=O)C=CC2=O)c23)c3n4C)c4c1 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":64003
  },
  {
    "COADD_ID":"CO-ADD:0278609",
    "INHIB_AVE":-4.39,
    "SMILES":"N1(Cc(ccc(c23)OCO2)c3)\\C(=N\\c(cccc4C(F)(F)F)c4)\\SC=C1c(cccc5[N+](=O)[O-])c5.Br",
    "HIT":0.0,
    "question":"Does N1(Cc(ccc(c23)OCO2)c3)\\C(=N\\c(cccc4C(F)(F)F)c4)\\SC=C1c(cccc5[N+](=O)[O-])c5.Br show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":70595
  },
  {
    "COADD_ID":"CO-ADD:0164953",
    "INHIB_AVE":6.25,
    "SMILES":"NC1=NC(=O)C(O1)c1ccccc1",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound NC1=NC(=O)C(O1)c1ccccc1?",
    "answer":"No",
    "_id":30180
  },
  {
    "COADD_ID":"CO-ADD:0252703",
    "INHIB_AVE":-1.28,
    "SMILES":"c1(cc(ccc1N)Cc(cc2)cc(c2C(O)=O)N)C(O)=O",
    "HIT":0.0,
    "question":"Is c1(cc(ccc1N)Cc(cc2)cc(c2C(O)=O)N)C(O)=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":62015
  },
  {
    "COADD_ID":"CO-ADD:0332380",
    "INHIB_AVE":4.22,
    "SMILES":"c1(c(F)cc(c(Cl)c1)C#N)N(CC2)CCN2C(c3ccccc3)=O",
    "HIT":0.0,
    "question":"Can exposure to c1(c(F)cc(c(Cl)c1)C#N)N(CC2)CCN2C(c3ccccc3)=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":39175
  },
  {
    "COADD_ID":"CO-ADD:0256915",
    "INHIB_AVE":-3.91,
    "SMILES":"N1(c2ccccc2)\\C(=N\\c3ccccc3)\\S\\C(=C\/c4cccc(C)n4)\\C1=O",
    "HIT":0.0,
    "question":"Is N1(c2ccccc2)\\C(=N\\c3ccccc3)\\S\\C(=C\/c4cccc(C)n4)\\C1=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":69542
  },
  {
    "COADD_ID":"CO-ADD:0235542",
    "INHIB_AVE":3.52,
    "SMILES":"c1(NC(CSCC(=O)OCC(=O)c2ccc(cc2)Br)=O)sc(c(ccc3C(OC)=O)n1)c3",
    "HIT":0.0,
    "question":"Does treatment with c1(NC(CSCC(=O)OCC(=O)c2ccc(cc2)Br)=O)sc(c(ccc3C(OC)=O)n1)c3 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":42294
  },
  {
    "COADD_ID":"CO-ADD:0327381",
    "INHIB_AVE":5.22,
    "SMILES":"N1(c2ccc(c(C)c2)C)C(c3ccc(c(OC)c3)OC)C(C1=O)Oc4ccc(cc4C)Cl",
    "HIT":0.0,
    "question":"Can exposure to N1(c2ccc(c(C)c2)C)C(c3ccc(c(OC)c3)OC)C(C1=O)Oc4ccc(cc4C)Cl lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":34665
  },
  {
    "COADD_ID":"CO-ADD:0154570",
    "INHIB_AVE":2.49,
    "SMILES":"O=C(C1=CC=CC(N(C)C)=C1)C2=CC(N(C)C)=CC=C2",
    "HIT":0.0,
    "question":"Does the proposed molecule O=C(C1=CC=CC(N(C)C)=C1)C2=CC(N(C)C)=CC=C2 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":46930
  },
  {
    "COADD_ID":"CO-ADD:0227736",
    "INHIB_AVE":-7.33,
    "SMILES":"N(C(=O)\\C(\\S1)=C\/c2ccccc2O)=C1N3CCCCC3",
    "HIT":0.0,
    "question":"Can N(C(=O)\\C(\\S1)=C\/c2ccccc2O)=C1N3CCCCC3 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":75828
  },
  {
    "COADD_ID":"CO-ADD:0286262",
    "INHIB_AVE":1.96,
    "SMILES":"N12[C@@]([H])(CSC1c3ccc(cc3)Br)C(N(c4ccc(cc4)Cl)C2=S)=O",
    "HIT":0.0,
    "question":"Does N12[C@@]([H])(CSC1c3ccc(cc3)Br)C(N(c4ccc(cc4)Cl)C2=S)=O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":49288
  },
  {
    "COADD_ID":"CO-ADD:0285559",
    "INHIB_AVE":-4.3,
    "SMILES":"C(OC)(=O)c1ccc(cc1)NC(COc(cc2)ccc2OC)=O",
    "HIT":0.0,
    "question":"Can C(OC)(=O)c1ccc(cc1)NC(COc(cc2)ccc2OC)=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":70420
  },
  {
    "COADD_ID":"CO-ADD:0311111",
    "INHIB_AVE":9.27,
    "SMILES":"N(\\C(=C\\c(ccc(c1OC)OCc2ccccc2)c1)\\C(O3)=O)=C3c4ccc(cc4)F",
    "HIT":0.0,
    "question":"Can N(\\C(=C\\c(ccc(c1OC)OCc2ccccc2)c1)\\C(O3)=O)=C3c4ccc(cc4)F act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":19128
  },
  {
    "COADD_ID":"CO-ADD:0332364",
    "INHIB_AVE":9.06,
    "SMILES":"C(C(C)(C)NC(C)(C)C#C)#C.Cl.Cl",
    "HIT":0.0,
    "question":"Can exposure to C(C(C)(C)NC(C)(C)C#C)#C.Cl.Cl lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":19705
  },
  {
    "COADD_ID":"CO-ADD:0244437",
    "INHIB_AVE":3.96,
    "SMILES":"c(N)(c1C)c(C)[nH]n1",
    "HIT":0.0,
    "question":"Does c(N)(c1C)c(C)[nH]n1 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":40344
  },
  {
    "COADD_ID":"CO-ADD:0232029",
    "INHIB_AVE":2.73,
    "SMILES":"c1(oc(c2n1)cccc2C)c3cc(ccc3O)\\N=C\\c4c(O)c(OC)cc(Br)c4Br",
    "HIT":0.0,
    "question":"Is c1(oc(c2n1)cccc2C)c3cc(ccc3O)\\N=C\\c4c(O)c(OC)cc(Br)c4Br effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":45849
  },
  {
    "COADD_ID":"CO-ADD:0259371",
    "INHIB_AVE":7.35,
    "SMILES":"c1(OC(N)=C(C2c3ccc(c4c3)OCO4)C#N)c2c(n[nH]1)CCC",
    "HIT":0.0,
    "question":"Does the proposed molecule c1(OC(N)=C(C2c3ccc(c4c3)OCO4)C#N)c2c(n[nH]1)CCC exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":25688
  },
  {
    "COADD_ID":"CO-ADD:0290336",
    "INHIB_AVE":-10.62,
    "SMILES":"C(OC)(=O)c1cccc(c1)NC(CSCc2ccccc2)=O",
    "HIT":0.0,
    "question":"Does C(OC)(=O)c1cccc(c1)NC(CSCc2ccccc2)=O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":79153
  },
  {
    "COADD_ID":"CO-ADD:0303947",
    "INHIB_AVE":9.21,
    "SMILES":"C(C(OCC)=O)(=CN(c1ccc(cc1)F)C=C2C(OCC)=O)C2c(cc3OC)cc(c3OC)OC",
    "HIT":0.0,
    "question":"Does C(C(OCC)=O)(=CN(c1ccc(cc1)F)C=C2C(OCC)=O)C2c(cc3OC)cc(c3OC)OC demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":19292
  },
  {
    "COADD_ID":"CO-ADD:0303939",
    "INHIB_AVE":8.6,
    "SMILES":"C(C(OCC)=O)(C1c2ccc(cc2)F)=CN(C=C1C(OCC)=O)c3cc(C)cc(C)c3",
    "HIT":0.0,
    "question":"Does treatment with C(C(OCC)=O)(C1c2ccc(cc2)F)=CN(C=C1C(OCC)=O)c3cc(C)cc(C)c3 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":21156
  },
  {
    "COADD_ID":"CO-ADD:0319220",
    "INHIB_AVE":2.07,
    "SMILES":"C(=O)(C(c1ccccc1)c2ccccc2)NCc3ccccc3F",
    "HIT":0.0,
    "question":"Is C(=O)(C(c1ccccc1)c2ccccc2)NCc3ccccc3F capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":48765
  },
  {
    "COADD_ID":"CO-ADD:0302917",
    "INHIB_AVE":2.22,
    "SMILES":"N1(c2ccc(c(C)c2)C)C(c3cccs3)N(N=C1C(C)=O)c4ccc(cc4)Cl",
    "HIT":0.0,
    "question":"Does treatment with N1(c2ccc(c(C)c2)C)C(c3cccs3)N(N=C1C(C)=O)c4ccc(cc4)Cl result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":48125
  },
  {
    "COADD_ID":"CO-ADD:0249714",
    "INHIB_AVE":9.85,
    "SMILES":"c1(c(ccc(c2Cl)Cl)c2)ccc(\\C=N\/NC(=O)c3ccc(cc3)F)o1",
    "HIT":0.0,
    "question":"Is c1(c(ccc(c2Cl)Cl)c2)ccc(\\C=N\/NC(=O)c3ccc(cc3)F)o1 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":17422
  },
  {
    "COADD_ID":"CO-ADD:0156252",
    "INHIB_AVE":2.19,
    "SMILES":"O=C(C)C(C=C1)=CC=C1\/N=C\/C2=C(O)C(Cl)=CC(Cl)=C2",
    "HIT":0.0,
    "question":"Is O=C(C)C(C=C1)=CC=C1\/N=C\/C2=C(O)C(Cl)=CC(Cl)=C2 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":48268
  },
  {
    "COADD_ID":"CO-ADD:0234904",
    "INHIB_AVE":19.55,
    "SMILES":"c1(c(Br)cc(cc1\\C=N\\NC(CNC(=O)c2cccc(F)c2)=O)Br)OC(c3ccccc3)=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(c(Br)cc(cc1\\C=N\\NC(CNC(=O)c2cccc(F)c2)=O)Br)OC(c3ccccc3)=O?",
    "answer":"No",
    "_id":3145
  },
  {
    "COADD_ID":"CO-ADD:0237415",
    "INHIB_AVE":3.02,
    "SMILES":"CC(C)CNS(=O)(=O)c1ccc(CCC(=O)Nc2ccc(Cl)cc2C)cc1",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound CC(C)CNS(=O)(=O)c1ccc(CCC(=O)Nc2ccc(Cl)cc2C)cc1?",
    "answer":"No",
    "_id":44559
  },
  {
    "COADD_ID":"CO-ADD:0229719",
    "INHIB_AVE":6.29,
    "SMILES":"C(=O)(c1ccc(cc1)Br)Oc2ccc(cc2OCC)\\C=N\\NC(COc3ccc(cc3Cl)Cl)=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C(=O)(c1ccc(cc1)Br)Oc2ccc(cc2OCC)\\C=N\\NC(COc3ccc(cc3Cl)Cl)=O?",
    "answer":"No",
    "_id":30060
  },
  {
    "COADD_ID":"CO-ADD:0245568",
    "INHIB_AVE":0.09,
    "SMILES":"C(=N\/NC(=O)c(cccn1)c1)(\/C2=O)\\c3c(N2)c(ccc3Cl)C",
    "HIT":0.0,
    "question":"Does the proposed molecule C(=N\/NC(=O)c(cccn1)c1)(\/C2=O)\\c3c(N2)c(ccc3Cl)C exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":57116
  },
  {
    "COADD_ID":"CO-ADD:0294027",
    "INHIB_AVE":13.05,
    "SMILES":"N1(CCCC1=O)C(CCCCC(=O)N2CCCC2=O)=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound N1(CCCC1=O)C(CCCCC(=O)N2CCCC2=O)=O?",
    "answer":"No",
    "_id":10477
  },
  {
    "COADD_ID":"CO-ADD:0331686",
    "INHIB_AVE":15.51,
    "SMILES":"S(=O)(=O)(c1ccc(cc1)F)NC(c(cccc2[N+](=O)[O-])c2)CC(O)=O",
    "HIT":0.0,
    "question":"Is S(=O)(=O)(c1ccc(cc1)F)NC(c(cccc2[N+](=O)[O-])c2)CC(O)=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":6931
  },
  {
    "COADD_ID":"CO-ADD:0294489",
    "INHIB_AVE":5.5,
    "SMILES":"C(C(c1ccccc1)=O)(C2c(cc3)ccc3[N+](=O)[O-])=C(O)C(N2CCCC(O)=O)=O",
    "HIT":0.0,
    "question":"Is C(C(c1ccccc1)=O)(C2c(cc3)ccc3[N+](=O)[O-])=C(O)C(N2CCCC(O)=O)=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":33443
  },
  {
    "COADD_ID":"CO-ADD:0247795",
    "INHIB_AVE":2.63,
    "SMILES":"c(c(N)ncn1CC(CO)O)(nc(n2)SCc3ccccc3)c12",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c(c(N)ncn1CC(CO)O)(nc(n2)SCc3ccccc3)c12?",
    "answer":"No",
    "_id":46286
  },
  {
    "COADD_ID":"CO-ADD:0158700",
    "INHIB_AVE":7.03,
    "SMILES":"[O-][N+](C1=CC(\/C=N\/C2=CC(C)=CC=C2C)=CC=C1OC(C3=C(Cl)C=C(Cl)C=C3)=O)=O",
    "HIT":0.0,
    "question":"Does treatment with [O-][N+](C1=CC(\/C=N\/C2=CC(C)=CC=C2C)=CC=C1OC(C3=C(Cl)C=C(Cl)C=C3)=O)=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":26865
  },
  {
    "COADD_ID":"CO-ADD:0300657",
    "INHIB_AVE":9.34,
    "SMILES":"C(C(OCCOC(C)C)=O)(C1c(cc2)ccc2[N+](=O)[O-])=C(C)NC(CC(C)(C)CC3=O)=C13",
    "HIT":0.0,
    "question":"Does treatment with C(C(OCCOC(C)C)=O)(C1c(cc2)ccc2[N+](=O)[O-])=C(C)NC(CC(C)(C)CC3=O)=C13 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":18926
  },
  {
    "COADD_ID":"CO-ADD:0307186",
    "INHIB_AVE":-11.6,
    "SMILES":"c1(c(CC(Cl)(Cl)Cl)c(n2CCC(O)=O)C)c2CC(C)(C)CC1=O",
    "HIT":0.0,
    "question":"Can c1(c(CC(Cl)(Cl)Cl)c(n2CCC(O)=O)C)c2CC(C)(C)CC1=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":79778
  },
  {
    "COADD_ID":"CO-ADD:0249144",
    "INHIB_AVE":-14.99,
    "SMILES":"C(=O)(Nc(cc(Sc1ccccc1)cc2Sc3ccccc3)c2)c4c(cccc4F)F",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C(=O)(Nc(cc(Sc1ccccc1)cc2Sc3ccccc3)c2)c4c(cccc4F)F?",
    "answer":"No",
    "_id":81290
  },
  {
    "COADD_ID":"CO-ADD:0235406",
    "INHIB_AVE":10.7,
    "SMILES":"c(c1)([N+](=O)[O-])ncn1[C@@H]2[C@@H](c3ccccc3)CC(=CC2=O)\\C=C\\c4ccccc4",
    "HIT":0.0,
    "question":"Can c(c1)([N+](=O)[O-])ncn1[C@@H]2[C@@H](c3ccccc3)CC(=CC2=O)\\C=C\\c4ccccc4 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":15208
  },
  {
    "COADD_ID":"CO-ADD:0148898",
    "INHIB_AVE":4.95,
    "SMILES":"n1c(c2cccc(c2)C#Cc3ccccc3)[nH]c(c4ccc(cc4)Cl)c1c5ccccc5",
    "HIT":0.0,
    "question":"Is n1c(c2cccc(c2)C#Cc3ccccc3)[nH]c(c4ccc(cc4)Cl)c1c5ccccc5 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":35883
  },
  {
    "COADD_ID":"CO-ADD:0160331",
    "INHIB_AVE":-5.26,
    "SMILES":"O=S(OC1=CC=C(C=C1)C(C2=C3C=CC=C2)(C4=C3C=CC=C4)C(C=C5)=CC=C5OS(C(C=C6)=CC=C6[N+]([O-])=O)(=O)=O)(C(C=C7)=CC=C7[N+]([O-])=O)=O",
    "HIT":0.0,
    "question":"Does O=S(OC1=CC=C(C=C1)C(C2=C3C=CC=C2)(C4=C3C=CC=C4)C(C=C5)=CC=C5OS(C(C=C6)=CC=C6[N+]([O-])=O)(=O)=O)(C(C=C7)=CC=C7[N+]([O-])=O)=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":72381
  },
  {
    "COADD_ID":"CO-ADD:0255003",
    "INHIB_AVE":7.69,
    "SMILES":"C(C#N)(C1c(cc2)ccc2N(CC)CC)=C(N)N(C(CC(C)(C)CC3=O)=C13)c4ccccc4",
    "HIT":0.0,
    "question":"Does C(C#N)(C1c(cc2)ccc2N(CC)CC)=C(N)N(C(CC(C)(C)CC3=O)=C13)c4ccccc4 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":24349
  },
  {
    "COADD_ID":"CO-ADD:0220846",
    "INHIB_AVE":0.61,
    "SMILES":"N(=C(\/C)\\c1ccc(cc1)Br)\/NC(CNc2c(Br)cc(c(Br)c2)Br)=O",
    "HIT":0.0,
    "question":"Does N(=C(\/C)\\c1ccc(cc1)Br)\/NC(CNc2c(Br)cc(c(Br)c2)Br)=O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":55049
  },
  {
    "COADD_ID":"CO-ADD:0227494",
    "INHIB_AVE":3.89,
    "SMILES":"c1(ccc(\\C=N\\NC(=O)\\C(=C\/c(ccc(c23)OCO2)c3)\\NC(c4ccccc4)=O)o1)c5cc(Cl)ccc5Cl",
    "HIT":0.0,
    "question":"Does the proposed molecule c1(ccc(\\C=N\\NC(=O)\\C(=C\/c(ccc(c23)OCO2)c3)\\NC(c4ccccc4)=O)o1)c5cc(Cl)ccc5Cl exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":40646
  },
  {
    "COADD_ID":"CO-ADD:0285105",
    "INHIB_AVE":-8.84,
    "SMILES":"N1(NC(Cc2ccccc2)=O)C(=O)C(C(C1=O)C34C)C(c(c35)cccc5)c(c46)cccc6",
    "HIT":0.0,
    "question":"Can N1(NC(Cc2ccccc2)=O)C(=O)C(C(C1=O)C34C)C(c(c35)cccc5)c(c46)cccc6 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":77682
  },
  {
    "COADD_ID":"CO-ADD:0230512",
    "INHIB_AVE":15.09,
    "SMILES":"N(=C\/c1ccccc1O)\/NC(CCCc(ccc(c2C)OC)c2)=O",
    "HIT":0.0,
    "question":"Is N(=C\/c1ccccc1O)\/NC(CCCc(ccc(c2C)OC)c2)=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":7485
  },
  {
    "COADD_ID":"CO-ADD:0226213",
    "INHIB_AVE":5.0,
    "SMILES":"S(=O)(=O)(N(Cc(cc1)ccc1F)c2ccc(cc2)C)c(ccc3n4c(C)nn3)c4",
    "HIT":0.0,
    "question":"Can exposure to S(=O)(=O)(N(Cc(cc1)ccc1F)c2ccc(cc2)C)c(ccc3n4c(C)nn3)c4 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":35625
  },
  {
    "COADD_ID":"CO-ADD:0242743",
    "INHIB_AVE":20.58,
    "SMILES":"C(=O)(C(CCCCNC(OCc1ccccc1)=O)NC(OCc2ccccc2)=O)Nc3cc(C)ccc3C",
    "HIT":0.0,
    "question":"Can exposure to C(=O)(C(CCCCNC(OCc1ccccc1)=O)NC(OCc2ccccc2)=O)Nc3cc(C)ccc3C lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":2549
  },
  {
    "COADD_ID":"CO-ADD:0237108",
    "INHIB_AVE":-2.04,
    "SMILES":"COc1ccc(cc1OCc2ccccn2)C3=NN(C4CCCCCC4)C(=O)C3(C)C",
    "HIT":0.0,
    "question":"Can COc1ccc(cc1OCc2ccccn2)C3=NN(C4CCCCCC4)C(=O)C3(C)C act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":64455
  },
  {
    "COADD_ID":"CO-ADD:0328753",
    "INHIB_AVE":-12.26,
    "SMILES":"c1(c(C)cc(nc1Cl)Cl)C(=O)N(CC2)CCO2",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(c(C)cc(nc1Cl)Cl)C(=O)N(CC2)CCO2?",
    "answer":"No",
    "_id":80189
  },
  {
    "COADD_ID":"CO-ADD:0215718",
    "INHIB_AVE":6.58,
    "SMILES":"c1(NC(=O)c2ccc(cc2Cl)Cl)sc(c(C)c1C#N)C",
    "HIT":0.0,
    "question":"Can c1(NC(=O)c2ccc(cc2Cl)Cl)sc(c(C)c1C#N)C effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":28772
  },
  {
    "COADD_ID":"CO-ADD:0237388",
    "INHIB_AVE":10.1,
    "SMILES":"COc1ccc(cc1)C2(CCCC2)C(=O)Nc3ccc(Br)cc3",
    "HIT":0.0,
    "question":"Does COc1ccc(cc1)C2(CCCC2)C(=O)Nc3ccc(Br)cc3 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":16718
  },
  {
    "COADD_ID":"CO-ADD:0293602",
    "INHIB_AVE":-0.37,
    "SMILES":"c1(NC(CSc2ccccn2)=O)sc(c3n1)ccc(cccc4)c34",
    "HIT":0.0,
    "question":"Does c1(NC(CSc2ccccn2)=O)sc(c3n1)ccc(cccc4)c34 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":58883
  },
  {
    "COADD_ID":"CO-ADD:0228039",
    "INHIB_AVE":10.6,
    "SMILES":"n1c2c(oc1c3cccc(c3)\\N=C\\c(cc(C)c(c4Br)C)c4O)ccc(C)c2",
    "HIT":0.0,
    "question":"Does the proposed molecule n1c2c(oc1c3cccc(c3)\\N=C\\c(cc(C)c(c4Br)C)c4O)ccc(C)c2 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":15467
  },
  {
    "COADD_ID":"CO-ADD:0252615",
    "INHIB_AVE":-25.31,
    "SMILES":"P1(=O)(Oc2ccccc2)Oc(cccc3)c3C(=O)N1c4ccccc4",
    "HIT":0.0,
    "question":"Does P1(=O)(Oc2ccccc2)Oc(cccc3)c3C(=O)N1c4ccccc4 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":82469
  },
  {
    "COADD_ID":"CO-ADD:0245420",
    "INHIB_AVE":0.11,
    "SMILES":"n1(c(cc(C)cc2C)c2n3)c3S\\C(=C\/c4ccc(cc4OC)OC)\\C1=O",
    "HIT":0.0,
    "question":"Can exposure to n1(c(cc(C)cc2C)c2n3)c3S\\C(=C\/c4ccc(cc4OC)OC)\\C1=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":57044
  },
  {
    "COADD_ID":"CO-ADD:0234724",
    "INHIB_AVE":15.12,
    "SMILES":"C(=O)(c1ccc(cc1)Br)Oc(cc2)ccc2\\C=N\\NC(CNC(=O)c3ccc(cc3)Cl)=O",
    "HIT":0.0,
    "question":"Is C(=O)(c1ccc(cc1)Br)Oc(cc2)ccc2\\C=N\\NC(CNC(=O)c3ccc(cc3)Cl)=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":7452
  },
  {
    "COADD_ID":"CO-ADD:0149331",
    "INHIB_AVE":6.92,
    "SMILES":"C1(CC(=O)Nc(c1cc2)cc2O)c(cc(OC)c3OC)cc3OC",
    "HIT":0.0,
    "question":"Does treatment with C1(CC(=O)Nc(c1cc2)cc2O)c(cc(OC)c3OC)cc3OC result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":27316
  },
  {
    "COADD_ID":"CO-ADD:0222733",
    "INHIB_AVE":6.32,
    "SMILES":"S(C)(=O)(=O)Nc1ccc(cn1)Br",
    "HIT":0.0,
    "question":"Can S(C)(=O)(=O)Nc1ccc(cn1)Br effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":29921
  },
  {
    "COADD_ID":"CO-ADD:0135599",
    "INHIB_AVE":-4.64,
    "SMILES":"[H]N1C(=S)N(CCCC)CC1",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound [H]N1C(=S)N(CCCC)CC1?",
    "answer":"No",
    "_id":71114
  },
  {
    "COADD_ID":"CO-ADD:0217959",
    "INHIB_AVE":-0.63,
    "SMILES":"N1C(C)(C)CC(CC1(C)C)\\N=C\\c2ccccc2O",
    "HIT":0.0,
    "question":"Does the proposed molecule N1C(C)(C)CC(CC1(C)C)\\N=C\\c2ccccc2O exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":59843
  },
  {
    "COADD_ID":"CO-ADD:0153043",
    "INHIB_AVE":-5.57,
    "SMILES":"O=C(N([H])C1=CN(C)C(C(N(C2=CN(C)C(C(N([H])CCCN(C)C)=O)=C2)[H])=O)=C1)C3=CC=C(C(OC)=O)C=C3.OC(C(F)(F)F)=O",
    "HIT":0.0,
    "question":"Is O=C(N([H])C1=CN(C)C(C(N(C2=CN(C)C(C(N([H])CCCN(C)C)=O)=C2)[H])=O)=C1)C3=CC=C(C(OC)=O)C=C3.OC(C(F)(F)F)=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":72955
  },
  {
    "COADD_ID":"CO-ADD:0240918",
    "INHIB_AVE":10.8,
    "SMILES":"N1(C(=O)c2c(C(c3ccc(cc3)CC)=N1)cccc2)c4cc(ccc4[N+](=O)[O-])N(CC5)CCN5C",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound N1(C(=O)c2c(C(c3ccc(cc3)CC)=N1)cccc2)c4cc(ccc4[N+](=O)[O-])N(CC5)CCN5C?",
    "answer":"No",
    "_id":14977
  },
  {
    "COADD_ID":"CO-ADD:0277855",
    "INHIB_AVE":-4.09,
    "SMILES":"N1(C2c3c(OC)ccc(cccc4)c34)C(S\\C(=C\\c(cc5)cc(c5N(C)C)Br)\\C1=O)=NC(c6ccccc6)=C2C(OCC)=O",
    "HIT":0.0,
    "question":"Does treatment with N1(C2c3c(OC)ccc(cccc4)c34)C(S\\C(=C\\c(cc5)cc(c5N(C)C)Br)\\C1=O)=NC(c6ccccc6)=C2C(OCC)=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":69959
  },
  {
    "COADD_ID":"CO-ADD:0225593",
    "INHIB_AVE":9.64,
    "SMILES":"N12C(=NN(CC(=O)Nc3c(C)cc(cc3C)C)C1=O)N(C(=O)c(n(cc4c5ccccc5)C)c24)C",
    "HIT":0.0,
    "question":"Can N12C(=NN(CC(=O)Nc3c(C)cc(cc3C)C)C1=O)N(C(=O)c(n(cc4c5ccccc5)C)c24)C effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":18042
  },
  {
    "COADD_ID":"CO-ADD:0220412",
    "INHIB_AVE":-0.63,
    "SMILES":"C(CNc(cc1)ccc1Cl)(=O)N\\N=C\\c(cc2)ccc2OCC",
    "HIT":0.0,
    "question":"Does treatment with C(CNc(cc1)ccc1Cl)(=O)N\\N=C\\c(cc2)ccc2OCC result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":59838
  },
  {
    "COADD_ID":"CO-ADD:0283505",
    "INHIB_AVE":-4.46,
    "SMILES":"N1(C2c3ccc(cc3OC)OC)C(S\\C(=C\\c(ccc(c4OCC)O)c4)\\C1=O)=NC(C)=C2C(OCC)=O",
    "HIT":0.0,
    "question":"Does N1(C2c3ccc(cc3OC)OC)C(S\\C(=C\\c(ccc(c4OCC)O)c4)\\C1=O)=NC(C)=C2C(OCC)=O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":70753
  },
  {
    "COADD_ID":"CO-ADD:0296043",
    "INHIB_AVE":13.35,
    "SMILES":"C(C(OCC)=O)(C(c1ccc(cc1)OCC)N2)=C(C)N(C2=O)CCO",
    "HIT":0.0,
    "question":"Is C(C(OCC)=O)(C(c1ccc(cc1)OCC)N2)=C(C)N(C2=O)CCO capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":9997
  },
  {
    "COADD_ID":"CO-ADD:0240868",
    "INHIB_AVE":10.76,
    "SMILES":"N1(c2ccc(cc2)CC)C(=O)C(C(C(C34)C(=C5c6ccccc6)C(C=C3)C(C4C7=O)C(N7c8ccc(cc8)CC)=O)C1=O)C5",
    "HIT":0.0,
    "question":"Is N1(c2ccc(cc2)CC)C(=O)C(C(C(C34)C(=C5c6ccccc6)C(C=C3)C(C4C7=O)C(N7c8ccc(cc8)CC)=O)C1=O)C5 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":15102
  },
  {
    "COADD_ID":"CO-ADD:0221000",
    "INHIB_AVE":5.03,
    "SMILES":"C(COc1ccc(cc1OC)Br)(=O)N\\N=C\\c(cc2)ccc2Br",
    "HIT":0.0,
    "question":"Is C(COc1ccc(cc1OC)Br)(=O)N\\N=C\\c(cc2)ccc2Br capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":35501
  },
  {
    "COADD_ID":"CO-ADD:0290894",
    "INHIB_AVE":9.51,
    "SMILES":"N1(CCSC1C(N)=O)c2ccc(cc2)C",
    "HIT":0.0,
    "question":"Can N1(CCSC1C(N)=O)c2ccc(cc2)C act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":18401
  },
  {
    "COADD_ID":"CO-ADD:0305542",
    "INHIB_AVE":12.31,
    "SMILES":"c1(ccc(cc1N2CCCCC2)N(CC3)CCN3C(=O)c4ccc(cc4)OC)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Does c1(ccc(cc1N2CCCCC2)N(CC3)CCN3C(=O)c4ccc(cc4)OC)[N+](=O)[O-] show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":11857
  },
  {
    "COADD_ID":"CO-ADD:0226513",
    "INHIB_AVE":21.81,
    "SMILES":"c12n(C=CN(c3ccc(cc3)OCC)C1=O)c(nn2)SCC(=O)c4ccc(cc4)F",
    "HIT":0.0,
    "question":"Can exposure to c12n(C=CN(c3ccc(cc3)OCC)C1=O)c(nn2)SCC(=O)c4ccc(cc4)F lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":1994
  },
  {
    "COADD_ID":"CO-ADD:0254773",
    "INHIB_AVE":-2.16,
    "SMILES":"N1(Cc2ccccc2)C(=O)C(C3C1=O)C(C(C4C(N5Cc6ccccc6)=O)C5=O)C(=C(C(=O)Oc7ccccc7)C34C)C",
    "HIT":0.0,
    "question":"Does treatment with N1(Cc2ccccc2)C(=O)C(C3C1=O)C(C(C4C(N5Cc6ccccc6)=O)C5=O)C(=C(C(=O)Oc7ccccc7)C34C)C result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":64855
  },
  {
    "COADD_ID":"CO-ADD:0257634",
    "INHIB_AVE":7.36,
    "SMILES":"N1(c2ccc(cc2)OC)C(=O)c(c3C1=O)ccc(c3)C(=O)Nc4cc(Cl)ccc4C(O)=O",
    "HIT":0.0,
    "question":"Does N1(c2ccc(cc2)OC)C(=O)c(c3C1=O)ccc(c3)C(=O)Nc4cc(Cl)ccc4C(O)=O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":25659
  },
  {
    "COADD_ID":"CO-ADD:0235136",
    "INHIB_AVE":-5.69,
    "SMILES":"C(=O)(c1ccc(cc1)Br)Oc2ccc(cc2OCC)\\C=N\\NC(COc(cc3)ccc3Cl)=O",
    "HIT":0.0,
    "question":"Does C(=O)(c1ccc(cc1)Br)Oc2ccc(cc2OCC)\\C=N\\NC(COc(cc3)ccc3Cl)=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":73149
  },
  {
    "COADD_ID":"CO-ADD:0155902",
    "INHIB_AVE":7.0,
    "SMILES":"N#CC([C@@H](C(C=CC=C1)=C1C(F)(F)F)[C@@H]2C(N)=O)(C#N)[C@@]3([H])N2C=CC4=C3C=CC=C4",
    "HIT":0.0,
    "question":"Can exposure to N#CC([C@@H](C(C=CC=C1)=C1C(F)(F)F)[C@@H]2C(N)=O)(C#N)[C@@]3([H])N2C=CC4=C3C=CC=C4 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":26971
  },
  {
    "COADD_ID":"CO-ADD:0160412",
    "INHIB_AVE":16.09,
    "SMILES":"CCN(CC)C(C=C1)=CC=C1\/C=N\/C2=NC(\/N=C\\C3=CC=C(C=C3)N(CC)CC)=NC(\/N=C\/C4=CC=C(N(CC)CC)C=C4)=N2",
    "HIT":0.0,
    "question":"Can CCN(CC)C(C=C1)=CC=C1\/C=N\/C2=NC(\/N=C\\C3=CC=C(C=C3)N(CC)CC)=NC(\/N=C\/C4=CC=C(N(CC)CC)C=C4)=N2 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":6263
  },
  {
    "COADD_ID":"CO-ADD:0158491",
    "INHIB_AVE":6.18,
    "SMILES":"[O-][N+](C1=CC=C(C(\/C=N\/NC(CNC(C=CC=C2)=C2C)=O)=C1)N3CCCC3)=O",
    "HIT":0.0,
    "question":"Does [O-][N+](C1=CC=C(C(\/C=N\/NC(CNC(C=CC=C2)=C2C)=O)=C1)N3CCCC3)=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":30494
  },
  {
    "COADD_ID":"CO-ADD:0137865",
    "INHIB_AVE":-7.67,
    "SMILES":"O=C1NC(N2C3=NC4=C(N3)C=CC=C4)=C(C(C)=N2)C(C5=CC=C(OC)C=C5)C1",
    "HIT":0.0,
    "question":"Is O=C1NC(N2C3=NC4=C(N3)C=CC=C4)=C(C(C)=N2)C(C5=CC=C(OC)C=C5)C1 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":76296
  },
  {
    "COADD_ID":"CO-ADD:0157480",
    "INHIB_AVE":2.19,
    "SMILES":"[O-][N+](C1=CC(OC(COC(C(Cl)=C2)=CC=C2Cl)=O)=CC([N+]([O-])=O)=C1)=O",
    "HIT":0.0,
    "question":"Can [O-][N+](C1=CC(OC(COC(C(Cl)=C2)=CC=C2Cl)=O)=CC([N+]([O-])=O)=C1)=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":48251
  },
  {
    "COADD_ID":"CO-ADD:0232749",
    "INHIB_AVE":5.87,
    "SMILES":"N1(c2cccc(Cl)c2)C(=O)C(CC1=O)S\\C(\\N)=N\\c(cc3)ccc3Br",
    "HIT":0.0,
    "question":"Does N1(c2cccc(Cl)c2)C(=O)C(CC1=O)S\\C(\\N)=N\\c(cc3)ccc3Br show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":31807
  },
  {
    "COADD_ID":"CO-ADD:0155952",
    "INHIB_AVE":2.29,
    "SMILES":"O=C(COC1=CC=C(C=C1)OCC2=CC=CC=C2)NC3=NN=NN3",
    "HIT":0.0,
    "question":"Can O=C(COC1=CC=C(C=C1)OCC2=CC=CC=C2)NC3=NN=NN3 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":47792
  },
  {
    "COADD_ID":"CO-ADD:0246008",
    "INHIB_AVE":-5.48,
    "SMILES":"c1(C#N)c2c(sc1\\N=C\\c(cc3)cc(c3OC(=O)c4cc(F)c(cc4Cl)F)OC)CCCC2",
    "HIT":0.0,
    "question":"Is c1(C#N)c2c(sc1\\N=C\\c(cc3)cc(c3OC(=O)c4cc(F)c(cc4Cl)F)OC)CCCC2 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":72804
  },
  {
    "COADD_ID":"CO-ADD:0292224",
    "INHIB_AVE":5.63,
    "SMILES":"n1c(c2ccc(cc2)CCC)onc1C(CC3)CCC3C4CCC(CC4)CCC",
    "HIT":0.0,
    "question":"Can n1c(c2ccc(cc2)CCC)onc1C(CC3)CCC3C4CCC(CC4)CCC act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":32788
  },
  {
    "COADD_ID":"CO-ADD:0245973",
    "INHIB_AVE":6.12,
    "SMILES":"c1(Nc2ccccc2)nc(NC)nc(N\\N=C\\c(cc3Br)cc(c3O)Br)n1",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(Nc2ccccc2)nc(NC)nc(N\\N=C\\c(cc3Br)cc(c3O)Br)n1?",
    "answer":"No",
    "_id":30771
  },
  {
    "COADD_ID":"CO-ADD:0278227",
    "INHIB_AVE":1.96,
    "SMILES":"n1(Cc2ccccc2)nnnc1SCC(=O)Nc(ccc(c3s4)nc4SCC(=O)Nc(cc5)ccc5C(C)C)c3",
    "HIT":0.0,
    "question":"Does n1(Cc2ccccc2)nnnc1SCC(=O)Nc(ccc(c3s4)nc4SCC(=O)Nc(cc5)ccc5C(C)C)c3 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":49299
  },
  {
    "COADD_ID":"CO-ADD:0220658",
    "INHIB_AVE":-0.58,
    "SMILES":"c1(O)c(Br)cc(cc1Br)\\C=N\\NC(CNC(=O)C(c2ccccc2)c3ccccc3)=O",
    "HIT":0.0,
    "question":"Can c1(O)c(Br)cc(cc1Br)\\C=N\\NC(CNC(=O)C(c2ccccc2)c3ccccc3)=O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":59692
  },
  {
    "COADD_ID":"CO-ADD:0277757",
    "INHIB_AVE":-4.45,
    "SMILES":"N1(c2ccc(cc2Br)Br)C(=O)CC(N(CC3)CCN3CC)C1=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound N1(c2ccc(cc2Br)Br)C(=O)CC(N(CC3)CCN3CC)C1=O?",
    "answer":"No",
    "_id":70746
  },
  {
    "COADD_ID":"CO-ADD:0306200",
    "INHIB_AVE":8.48,
    "SMILES":"N(CCc1ccccc1)(CC2)CC(C2=O)C.Cl",
    "HIT":0.0,
    "question":"Does N(CCc1ccccc1)(CC2)CC(C2=O)C.Cl demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":21513
  },
  {
    "COADD_ID":"CO-ADD:0305369",
    "INHIB_AVE":9.4,
    "SMILES":"N1(CNc(cc2)ccc2O)C(=O)C(C3C1=O)C(CC34)C=C4",
    "HIT":0.0,
    "question":"Does N1(CNc(cc2)ccc2O)C(=O)C(C3C1=O)C(CC34)C=C4 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":18727
  },
  {
    "COADD_ID":"CO-ADD:0301178",
    "INHIB_AVE":-10.9,
    "SMILES":"c1(SCC(=O)Nc2ccc(cc2OC)OC)sc(c3n1)cccc3",
    "HIT":0.0,
    "question":"Is c1(SCC(=O)Nc2ccc(cc2OC)OC)sc(c3n1)cccc3 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":79361
  },
  {
    "COADD_ID":"CO-ADD:0293677",
    "INHIB_AVE":5.53,
    "SMILES":"[nH](c(ccc(c1)C(O)=O)c1c2CCN)c2C.Cl",
    "HIT":0.0,
    "question":"Can exposure to [nH](c(ccc(c1)C(O)=O)c1c2CCN)c2C.Cl lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":33296
  },
  {
    "COADD_ID":"CO-ADD:0291449",
    "INHIB_AVE":-0.18,
    "SMILES":"C1(C(N)=O)OC(OC1C(N)=O)(C)C(C)(C)C",
    "HIT":0.0,
    "question":"Can C1(C(N)=O)OC(OC1C(N)=O)(C)C(C)(C)C act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":58185
  },
  {
    "COADD_ID":"CO-ADD:0259945",
    "INHIB_AVE":13.46,
    "SMILES":"C(\/SC(C1=O)CC(=O)Nc(cc2)ccc2C(O)=O)(=N\/c3c(C)cccc3C)\\N1C",
    "HIT":0.0,
    "question":"Does treatment with C(\/SC(C1=O)CC(=O)Nc(cc2)ccc2C(O)=O)(=N\/c3c(C)cccc3C)\\N1C result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":9818
  },
  {
    "COADD_ID":"CO-ADD:0331340",
    "INHIB_AVE":-1.23,
    "SMILES":"C1(C(=O)NC(N2CC(C)C)=O)=C2NC(=O)C1(NC(C)=O)C(F)(F)F",
    "HIT":0.0,
    "question":"Can exposure to C1(C(=O)NC(N2CC(C)C)=O)=C2NC(=O)C1(NC(C)=O)C(F)(F)F lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":61844
  },
  {
    "COADD_ID":"CO-ADD:0242365",
    "INHIB_AVE":0.12,
    "SMILES":"C1(C#N)(C#N)[C@@H]([C@H]1C(N)=O)c2ccc(cc2)Cl",
    "HIT":0.0,
    "question":"Is C1(C#N)(C#N)[C@@H]([C@H]1C(N)=O)c2ccc(cc2)Cl capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":57016
  },
  {
    "COADD_ID":"CO-ADD:0285376",
    "INHIB_AVE":14.35,
    "SMILES":"C12(C#N)C(C#N)(C3=C(CCCC3)NC1c4ccccc4)C(N5C2=NC(c6ccccc6)NC5c7ccccc7)=O",
    "HIT":0.0,
    "question":"Does C12(C#N)C(C#N)(C3=C(CCCC3)NC1c4ccccc4)C(N5C2=NC(c6ccccc6)NC5c7ccccc7)=O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":8495
  },
  {
    "COADD_ID":"CO-ADD:0286730",
    "INHIB_AVE":3.39,
    "SMILES":"C(\/S\\C(\\N1CC)=N\/c(cc2)ccc2C(C)=O)(\\C1=O)=C(\/Sc(c34)ccc(OC)c3)\\N4C",
    "HIT":0.0,
    "question":"Can exposure to C(\/S\\C(\\N1CC)=N\/c(cc2)ccc2C(C)=O)(\\C1=O)=C(\/Sc(c34)ccc(OC)c3)\\N4C lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":42852
  },
  {
    "COADD_ID":"CO-ADD:0331961",
    "INHIB_AVE":18.43,
    "SMILES":"C1(=Cc(c2)c(OC1=O)ccc2[N+](=O)[O-])C(=O)NC(c3ccc(cc3)OC)CC(OCC)=O",
    "HIT":0.0,
    "question":"Is C1(=Cc(c2)c(OC1=O)ccc2[N+](=O)[O-])C(=O)NC(c3ccc(cc3)OC)CC(OCC)=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":3956
  },
  {
    "COADD_ID":"CO-ADD:0166429",
    "INHIB_AVE":14.79,
    "SMILES":"C(COc(cc1)ccc1CC)(=O)Nc(cc2)ccc2OCCCCC",
    "HIT":0.0,
    "question":"Does treatment with C(COc(cc1)ccc1CC)(=O)Nc(cc2)ccc2OCCCCC result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":7873
  },
  {
    "COADD_ID":"CO-ADD:0329180",
    "INHIB_AVE":19.17,
    "SMILES":"N#CCc(cc1)ccc1NC(CCCOc2ccc(cc2Cl)Cl)=O",
    "HIT":0.0,
    "question":"Is N#CCc(cc1)ccc1NC(CCCOc2ccc(cc2Cl)Cl)=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":3403
  },
  {
    "COADD_ID":"CO-ADD:0157845",
    "INHIB_AVE":6.2,
    "SMILES":"[O-][N+](C(C=CC=C1)=C1\/C=N\/NC(C(O)C(C=C2)=CC=C2Br)=O)=O",
    "HIT":0.0,
    "question":"Does the proposed molecule [O-][N+](C(C=CC=C1)=C1\/C=N\/NC(C(O)C(C=C2)=CC=C2Br)=O)=O exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":30414
  },
  {
    "COADD_ID":"CO-ADD:0220877",
    "INHIB_AVE":16.91,
    "SMILES":"C(C(=O)N(CC1)CCO1)(C2c3ccccc3)C(C2C(=O)N\\N=C\\c(cc4)ccc4Br)c5ccccc5",
    "HIT":0.0,
    "question":"Can exposure to C(C(=O)N(CC1)CCO1)(C2c3ccccc3)C(C2C(=O)N\\N=C\\c(cc4)ccc4Br)c5ccccc5 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":5368
  },
  {
    "COADD_ID":"CO-ADD:0247952",
    "INHIB_AVE":2.69,
    "SMILES":"C(F)(F)(F)c(ccc(c1\\N=C\\c2cccc(Cl)c2O)N3CCCC3)c1",
    "HIT":0.0,
    "question":"Does treatment with C(F)(F)(F)c(ccc(c1\\N=C\\c2cccc(Cl)c2O)N3CCCC3)c1 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":46038
  },
  {
    "COADD_ID":"CO-ADD:0252538",
    "INHIB_AVE":1.09,
    "SMILES":"N1(C2c3ccc(cc3)Cl)C(S\\C(=C\\c(ccc4c5ccc(cc5[N+](=O)[O-])Cl)o4)\\C1=O)=NC(C)=C2C(OCC)=O",
    "HIT":0.0,
    "question":"Does N1(C2c3ccc(cc3)Cl)C(S\\C(=C\\c(ccc4c5ccc(cc5[N+](=O)[O-])Cl)o4)\\C1=O)=NC(C)=C2C(OCC)=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":53069
  },
  {
    "COADD_ID":"CO-ADD:0258891",
    "INHIB_AVE":-8.87,
    "SMILES":"C(=O)(Nc1cccc(SC)c1)\\C=C\/C(O)=O",
    "HIT":0.0,
    "question":"Does the proposed molecule C(=O)(Nc1cccc(SC)c1)\\C=C\/C(O)=O exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":77711
  },
  {
    "COADD_ID":"CO-ADD:0256649",
    "INHIB_AVE":8.76,
    "SMILES":"N1(CCCCCCCCCCCC)C(C)(O)C2(OC1=O)CCCCC2",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound N1(CCCCCCCCCCCC)C(C)(O)C2(OC1=O)CCCCC2?",
    "answer":"No",
    "_id":20662
  },
  {
    "COADD_ID":"CO-ADD:0220056",
    "INHIB_AVE":-4.84,
    "SMILES":"C(=O)(Nc1ccc(cn1)Cl)c2ccccc2Br",
    "HIT":0.0,
    "question":"Can C(=O)(Nc1ccc(cn1)Cl)c2ccccc2Br effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":71533
  },
  {
    "COADD_ID":"CO-ADD:0225526",
    "INHIB_AVE":-0.56,
    "SMILES":"n(c1c(cccc1)nc2SCc3c(C)oc(c4ccc(cc4)OC)n3)(c(C(C)C)nn5)c25",
    "HIT":0.0,
    "question":"Does the proposed molecule n(c1c(cccc1)nc2SCc3c(C)oc(c4ccc(cc4)OC)n3)(c(C(C)C)nn5)c25 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":59570
  },
  {
    "COADD_ID":"CO-ADD:0259338",
    "INHIB_AVE":-5.88,
    "SMILES":"n1(cc(n2)c3ccc(c(O)c3)O)c2ccc(C)c1.Cl",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound n1(cc(n2)c3ccc(c(O)c3)O)c2ccc(C)c1.Cl?",
    "answer":"No",
    "_id":73506
  },
  {
    "COADD_ID":"CO-ADD:0217740",
    "INHIB_AVE":9.75,
    "SMILES":"S(=O)(=O)(c1ccc(cc1)C)Oc2ccccc2\\C=N\\Nc(cc3)ccc3[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound S(=O)(=O)(c1ccc(cc1)C)Oc2ccccc2\\C=N\\Nc(cc3)ccc3[N+](=O)[O-]?",
    "answer":"No",
    "_id":17711
  },
  {
    "COADD_ID":"CO-ADD:0323215",
    "INHIB_AVE":-3.06,
    "SMILES":"N1(c2ccc(cc2)F)C(=O)\\C(\\C(CCC)=N1)=C\/NCC(CC3)CCN3",
    "HIT":0.0,
    "question":"Is N1(c2ccc(cc2)F)C(=O)\\C(\\C(CCC)=N1)=C\/NCC(CC3)CCN3 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":67402
  },
  {
    "COADD_ID":"CO-ADD:0135642",
    "INHIB_AVE":8.95,
    "SMILES":"[H]n1cc(C(CCN2C)C2)c(ccc3)c1c3",
    "HIT":0.0,
    "question":"Can [H]n1cc(C(CCN2C)C2)c(ccc3)c1c3 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":20043
  },
  {
    "COADD_ID":"CO-ADD:0161416",
    "INHIB_AVE":-5.23,
    "SMILES":"[N+](=O)([O-])c(cc1)cc(c1N(C)C2CCCCC2)\\C=N\\NC(COc(cc3)ccc3Cl)=O",
    "HIT":0.0,
    "question":"Is [N+](=O)([O-])c(cc1)cc(c1N(C)C2CCCCC2)\\C=N\\NC(COc(cc3)ccc3Cl)=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":72305
  },
  {
    "COADD_ID":"CO-ADD:0249224",
    "INHIB_AVE":-3.86,
    "SMILES":"c1(\\C=N\\c(cc2)ccc2\\N=C\\c3c4c([nH]c3C)cccc4)c5c([nH]c1C)cccc5",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(\\C=N\\c(cc2)ccc2\\N=C\\c3c4c([nH]c3C)cccc4)c5c([nH]c1C)cccc5?",
    "answer":"No",
    "_id":69414
  },
  {
    "COADD_ID":"CO-ADD:0249553",
    "INHIB_AVE":1.29,
    "SMILES":"C1(C2=O)C(C(C=C3)OC13C)C(N2c4ccc(cc4)OC)=O",
    "HIT":0.0,
    "question":"Does the proposed molecule C1(C2=O)C(C(C=C3)OC13C)C(N2c4ccc(cc4)OC)=O exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":52190
  },
  {
    "COADD_ID":"CO-ADD:0218221",
    "INHIB_AVE":3.81,
    "SMILES":"N(=C\\c1ccccc1)\/c(cc2)c(C)cc2c3ccc(c(C)c3)\\N=C\\c4ccccc4",
    "HIT":0.0,
    "question":"Is N(=C\\c1ccccc1)\/c(cc2)c(C)cc2c3ccc(c(C)c3)\\N=C\\c4ccccc4 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":41065
  },
  {
    "COADD_ID":"CO-ADD:0162111",
    "INHIB_AVE":0.26,
    "SMILES":"S(c1ccccc1)(=O)(=O)N2CCN(CC2C(=O)NC(C)C)S(c3ccccc3)(=O)=O",
    "HIT":0.0,
    "question":"Is S(c1ccccc1)(=O)(=O)N2CCN(CC2C(=O)NC(C)C)S(c3ccccc3)(=O)=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":56434
  },
  {
    "COADD_ID":"CO-ADD:0249446",
    "INHIB_AVE":2.69,
    "SMILES":"c1([nH]c(c23)ccc(C)c2)c3nnc(N\\N=C\\c4ccccc4C(F)(F)F)n1",
    "HIT":0.0,
    "question":"Does c1([nH]c(c23)ccc(C)c2)c3nnc(N\\N=C\\c4ccccc4C(F)(F)F)n1 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":46021
  },
  {
    "COADD_ID":"CO-ADD:0296068",
    "INHIB_AVE":1.78,
    "SMILES":"C(C(c1ccccc1)=O)(C2c3ccc(cc3)C)=C(O)C(N2CCCOC)=O",
    "HIT":0.0,
    "question":"Is C(C(c1ccccc1)=O)(C2c3ccc(cc3)C)=C(O)C(N2CCCOC)=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":50084
  },
  {
    "COADD_ID":"CO-ADD:0230875",
    "INHIB_AVE":1.38,
    "SMILES":"C(=C\/c(ccc(c1OC)OC)c1)(\/c(cc(cc2[N+](=O)[O-])[N+](=O)[O-])c23)\\c(cc(cc4[N+](=O)[O-])[N+](=O)[O-])c34",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C(=C\/c(ccc(c1OC)OC)c1)(\/c(cc(cc2[N+](=O)[O-])[N+](=O)[O-])c23)\\c(cc(cc4[N+](=O)[O-])[N+](=O)[O-])c34?",
    "answer":"No",
    "_id":51832
  },
  {
    "COADD_ID":"CO-ADD:0304524",
    "INHIB_AVE":-6.36,
    "SMILES":"C(C(=O)Nc(cc1)ccc1Cl)(=C(C)NC(=C2C#N)SCC(N)=O)C2c3ccco3",
    "HIT":0.0,
    "question":"Can C(C(=O)Nc(cc1)ccc1Cl)(=C(C)NC(=C2C#N)SCC(N)=O)C2c3ccco3 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":74344
  },
  {
    "COADD_ID":"CO-ADD:0258688",
    "INHIB_AVE":-15.54,
    "SMILES":"C12(\\C=C\\c(cc3)ccc3Br)N(CCC(=O)N1)c4c(cccc4)C2(C)C",
    "HIT":0.0,
    "question":"Is C12(\\C=C\\c(cc3)ccc3Br)N(CCC(=O)N1)c4c(cccc4)C2(C)C capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":81449
  },
  {
    "COADD_ID":"CO-ADD:0284082",
    "INHIB_AVE":7.36,
    "SMILES":"N1(CC(OCC)=O)\\C(=N\\c(cc2)ccc2F)\\SC=C1c3cc(C)ccc3C.Br",
    "HIT":0.0,
    "question":"Is N1(CC(OCC)=O)\\C(=N\\c(cc2)ccc2F)\\SC=C1c3cc(C)ccc3C.Br capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":25654
  },
  {
    "COADD_ID":"CO-ADD:0292411",
    "INHIB_AVE":13.35,
    "SMILES":"C(C#N)(C(c(cccc1[N+](=O)[O-])c1)C2=C(N3c4ccccc4F)CC(C)(C)CC2=O)=C3N",
    "HIT":0.0,
    "question":"Does treatment with C(C#N)(C(c(cccc1[N+](=O)[O-])c1)C2=C(N3c4ccccc4F)CC(C)(C)CC2=O)=C3N result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":9996
  },
  {
    "COADD_ID":"CO-ADD:0295371",
    "INHIB_AVE":2.38,
    "SMILES":"C(\/c1ccccc1Cl)(\\c2ccccc2Cl)=C(\\C3CCN4CC3)\/C4.Cl",
    "HIT":0.0,
    "question":"Does the proposed molecule C(\/c1ccccc1Cl)(\\c2ccccc2Cl)=C(\\C3CCN4CC3)\/C4.Cl exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":47411
  },
  {
    "COADD_ID":"CO-ADD:0219593",
    "INHIB_AVE":-7.33,
    "SMILES":"C(=O)(N\\N=C\\c(cc1)ccc1F)C(=O)Nc2ccc(cc2C)Cl",
    "HIT":0.0,
    "question":"Does C(=O)(N\\N=C\\c(cc1)ccc1F)C(=O)Nc2ccc(cc2C)Cl show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":75811
  },
  {
    "COADD_ID":"CO-ADD:0241052",
    "INHIB_AVE":6.1,
    "SMILES":"N1(\\N=C\\c2c(OCC)ccc(cccc3)c23)C(=O)C(C4C1=O)C5C=CC4CC5",
    "HIT":0.0,
    "question":"Is N1(\\N=C\\c2c(OCC)ccc(cccc3)c23)C(=O)C(C4C1=O)C5C=CC4CC5 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":30826
  },
  {
    "COADD_ID":"CO-ADD:0326623",
    "INHIB_AVE":-3.55,
    "SMILES":"N1(CCC(NCCc(ccc(c2OCC)OCC)c2)=O)C(=O)c(c3C1=O)cccc3",
    "HIT":0.0,
    "question":"Does the proposed molecule N1(CCC(NCCc(ccc(c2OCC)OCC)c2)=O)C(=O)c(c3C1=O)cccc3 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":68666
  },
  {
    "COADD_ID":"CO-ADD:0136093",
    "INHIB_AVE":15.71,
    "SMILES":"n1cccc(NC(=O)c(cc([N+](=O)[O-])cc2)c2)c1",
    "HIT":0.0,
    "question":"Can exposure to n1cccc(NC(=O)c(cc([N+](=O)[O-])cc2)c2)c1 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":6701
  },
  {
    "COADD_ID":"CO-ADD:0284394",
    "INHIB_AVE":-9.63,
    "SMILES":"C(=O)(C(c1ccccc1)c2ccccc2)Nc3ccccc3C#Cc4ccccc4NC(=O)C(c5ccccc5)c6ccccc6",
    "HIT":0.0,
    "question":"Can exposure to C(=O)(C(c1ccccc1)c2ccccc2)Nc3ccccc3C#Cc4ccccc4NC(=O)C(c5ccccc5)c6ccccc6 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":78419
  },
  {
    "COADD_ID":"CO-ADD:0226867",
    "INHIB_AVE":1.61,
    "SMILES":"C1(=N2)N(c3c(cccc3)N=C1N(CC4)CCS4)C(N2CC(=O)Nc5c(C)cccc5C)=O",
    "HIT":0.0,
    "question":"Is C1(=N2)N(c3c(cccc3)N=C1N(CC4)CCS4)C(N2CC(=O)Nc5c(C)cccc5C)=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":50837
  },
  {
    "COADD_ID":"CO-ADD:0160260",
    "INHIB_AVE":3.62,
    "SMILES":"O=C(N\/N=C\/C1=CC=C(F)C=C1)CN2N=NC3=C2C=CC=C3",
    "HIT":0.0,
    "question":"Can O=C(N\/N=C\/C1=CC=C(F)C=C1)CN2N=NC3=C2C=CC=C3 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":41849
  },
  {
    "COADD_ID":"CO-ADD:0305943",
    "INHIB_AVE":5.48,
    "SMILES":"c([N+](=O)[O-])(nn(c1C(=O)Nc2sc(c(C)c2C(OC)=O)C)Cc3ccccc3)c1",
    "HIT":0.0,
    "question":"Can c([N+](=O)[O-])(nn(c1C(=O)Nc2sc(c(C)c2C(OC)=O)C)Cc3ccccc3)c1 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":33538
  },
  {
    "COADD_ID":"CO-ADD:0226543",
    "INHIB_AVE":2.96,
    "SMILES":"c12n(C=CN(c3ccc(cc3)F)C1=O)c(nn2)SCc4ccccc4Cl",
    "HIT":0.0,
    "question":"Does treatment with c12n(C=CN(c3ccc(cc3)F)C1=O)c(nn2)SCc4ccccc4Cl result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":44800
  },
  {
    "COADD_ID":"CO-ADD:0258684",
    "INHIB_AVE":5.75,
    "SMILES":"c1(OC(=O)C=C2C)c2ccc(OC(C)C(OCC)=O)c1C(C)=O",
    "HIT":0.0,
    "question":"Is c1(OC(=O)C=C2C)c2ccc(OC(C)C(OCC)=O)c1C(C)=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":32317
  },
  {
    "COADD_ID":"CO-ADD:0252869",
    "INHIB_AVE":8.61,
    "SMILES":"c1(N2CCC(CC2)C)nc(N\\N=C\\c3cc(Br)ccc3OCc4ccccc4)nc(Nc5cccc(C)c5C)n1.Cl",
    "HIT":0.0,
    "question":"Does treatment with c1(N2CCC(CC2)C)nc(N\\N=C\\c3cc(Br)ccc3OCc4ccccc4)nc(Nc5cccc(C)c5C)n1.Cl result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":21113
  },
  {
    "COADD_ID":"CO-ADD:0230969",
    "INHIB_AVE":8.24,
    "SMILES":"n(c(OC)nc(n1)OC)c1NCc(cccn2)c2",
    "HIT":0.0,
    "question":"Does n(c(OC)nc(n1)OC)c1NCc(cccn2)c2 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":22347
  },
  {
    "COADD_ID":"CO-ADD:0223676",
    "INHIB_AVE":-17.11,
    "SMILES":"C(=O)(N\\N=C\\c1cc(OC)ccc1Br)C(C)Oc2cccc(Cl)c2",
    "HIT":0.0,
    "question":"Does C(=O)(N\\N=C\\c1cc(OC)ccc1Br)C(C)Oc2cccc(Cl)c2 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":81770
  },
  {
    "COADD_ID":"CO-ADD:0244948",
    "INHIB_AVE":8.81,
    "SMILES":"c1(Sc2ccc(cc2[N+](=O)[O-])\\C=N\\c(ccc(c3C)C)c3)sc(c(ccc4[N+](=O)[O-])n1)c4",
    "HIT":0.0,
    "question":"Can c1(Sc2ccc(cc2[N+](=O)[O-])\\C=N\\c(ccc(c3C)C)c3)sc(c(ccc4[N+](=O)[O-])n1)c4 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":20503
  },
  {
    "COADD_ID":"CO-ADD:0227552",
    "INHIB_AVE":-1.96,
    "SMILES":"c1(c(Br)cc(cc1\\C=N\\NC(COc2cc(C)ccc2C(C)C)=O)Br)OC(c3ccccc3)=O",
    "HIT":0.0,
    "question":"Is c1(c(Br)cc(cc1\\C=N\\NC(COc2cc(C)ccc2C(C)C)=O)Br)OC(c3ccccc3)=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":64226
  },
  {
    "COADD_ID":"CO-ADD:0219619",
    "INHIB_AVE":1.64,
    "SMILES":"[N+](=O)([O-])c(cc(N)cc1C(=O)N\\N=C(\/C)\\CC(=O)Nc2ccccc2Br)c1",
    "HIT":0.0,
    "question":"Does [N+](=O)([O-])c(cc(N)cc1C(=O)N\\N=C(\/C)\\CC(=O)Nc2ccccc2Br)c1 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":50683
  },
  {
    "COADD_ID":"CO-ADD:0306293",
    "INHIB_AVE":6.84,
    "SMILES":"N1(CC(OC)=O)C(=O)c2c(cc(cc2[N+](=O)[O-])[N+](=O)[O-])S1=O",
    "HIT":0.0,
    "question":"Does N1(CC(OC)=O)C(=O)c2c(cc(cc2[N+](=O)[O-])[N+](=O)[O-])S1=O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":27633
  },
  {
    "COADD_ID":"CO-ADD:0278782",
    "INHIB_AVE":1.96,
    "SMILES":"C1(=C(CC(C)(C)CC1=O)OC(=C23)CC(CC2=O)(C)C)C3c4cccc(c4)OCc5c(cccc5F)Cl",
    "HIT":0.0,
    "question":"Is C1(=C(CC(C)(C)CC1=O)OC(=C23)CC(CC2=O)(C)C)C3c4cccc(c4)OCc5c(cccc5F)Cl capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":49284
  },
  {
    "COADD_ID":"CO-ADD:0293385",
    "INHIB_AVE":0.65,
    "SMILES":"N1(N=C(N2)N)C2=NC(C(C)C)=CC1=O",
    "HIT":0.0,
    "question":"Does N1(N=C(N2)N)C2=NC(C(C)C)=CC1=O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":54906
  },
  {
    "COADD_ID":"CO-ADD:0217387",
    "INHIB_AVE":10.49,
    "SMILES":"[N+](=O)([O-])c(cc1)ccc1C(=O)Oc2cccc(c2)\\C=N\\NC(=O)c(ccc(n3)C)c3",
    "HIT":0.0,
    "question":"Does treatment with [N+](=O)([O-])c(cc1)ccc1C(=O)Oc2cccc(c2)\\C=N\\NC(=O)c(ccc(n3)C)c3 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":15773
  },
  {
    "COADD_ID":"CO-ADD:0160152",
    "INHIB_AVE":16.05,
    "SMILES":"O=C(N\/N=C\/C1=CC(Br)=CC=C1OCC)C2=CC=C3C(C=CC=C3)=N2",
    "HIT":0.0,
    "question":"Is O=C(N\/N=C\/C1=CC(Br)=CC=C1OCC)C2=CC=C3C(C=CC=C3)=N2 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":6304
  },
  {
    "COADD_ID":"CO-ADD:0305473",
    "INHIB_AVE":6.8,
    "SMILES":"c1(scc(c(cccc2[N+](=O)[O-])c2)n1)N3CCCC3C(=O)OCc4ccccc4",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(scc(c(cccc2[N+](=O)[O-])c2)n1)N3CCCC3C(=O)OCc4ccccc4?",
    "answer":"No",
    "_id":27834
  },
  {
    "COADD_ID":"CO-ADD:0216999",
    "INHIB_AVE":0.31,
    "SMILES":"C(=O)(C\\C(\\C)=N\\NC(COc(cc1)ccc1Br)=O)Nc2cc(C)ccc2OC",
    "HIT":0.0,
    "question":"Can C(=O)(C\\C(\\C)=N\\NC(COc(cc1)ccc1Br)=O)Nc2cc(C)ccc2OC effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":56196
  },
  {
    "COADD_ID":"CO-ADD:0252333",
    "INHIB_AVE":-14.98,
    "SMILES":"C(SCCC)(=O)Nc(ccc(c1Cl)Cl)c1",
    "HIT":0.0,
    "question":"Can C(SCCC)(=O)Nc(ccc(c1Cl)Cl)c1 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":81288
  },
  {
    "COADD_ID":"CO-ADD:0165969",
    "INHIB_AVE":-4.67,
    "SMILES":"c(c(Br)c(C)cc1OCC(=O)N\\N=C(\/C)\\CC(NCC=C)=O)c1Br",
    "HIT":0.0,
    "question":"Does treatment with c(c(Br)c(C)cc1OCC(=O)N\\N=C(\/C)\\CC(NCC=C)=O)c1Br result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":71176
  },
  {
    "COADD_ID":"CO-ADD:0291046",
    "INHIB_AVE":-2.95,
    "SMILES":"S(=O)(=O)(c1c(OC)ccc(Cl)c1)n2c(C)ncc2[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Is S(=O)(=O)(c1c(OC)ccc(Cl)c1)n2c(C)ncc2[N+](=O)[O-] effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":67136
  },
  {
    "COADD_ID":"CO-ADD:0229262",
    "INHIB_AVE":4.99,
    "SMILES":"c1(NC(C)=O)c2c(oc1Cl)cccc2",
    "HIT":0.0,
    "question":"Can exposure to c1(NC(C)=O)c2c(oc1Cl)cccc2 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":35688
  },
  {
    "COADD_ID":"CO-ADD:0327885",
    "INHIB_AVE":-1.75,
    "SMILES":"c1(ccc(c(cccn2)c12)Sc3nnc(N)s3)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Does c1(ccc(c(cccn2)c12)Sc3nnc(N)s3)[N+](=O)[O-] show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":63580
  },
  {
    "COADD_ID":"CO-ADD:0292815",
    "INHIB_AVE":14.0,
    "SMILES":"[N+](=O)([O-])c(cccc1c2ccc(\\C=C\/C(=O)N(CC3)CCO3)o2)c1",
    "HIT":0.0,
    "question":"Is [N+](=O)([O-])c(cccc1c2ccc(\\C=C\/C(=O)N(CC3)CCO3)o2)c1 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":9035
  },
  {
    "COADD_ID":"CO-ADD:0222808",
    "INHIB_AVE":-0.66,
    "SMILES":"[N+](=O)([O-])c1ccc(cc1)\\C=C\\C(=O)Oc(cc2)ccc2\\C=N\\c3ccccn3",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound [N+](=O)([O-])c1ccc(cc1)\\C=C\\C(=O)Oc(cc2)ccc2\\C=N\\c3ccccn3?",
    "answer":"No",
    "_id":59948
  },
  {
    "COADD_ID":"CO-ADD:0256787",
    "INHIB_AVE":10.38,
    "SMILES":"[N+](=O)([O-])c1c(ccc(c1)C(F)(F)F)SCC(=O)Nc2cccc(Cl)c2",
    "HIT":0.0,
    "question":"Does [N+](=O)([O-])c1c(ccc(c1)C(F)(F)F)SCC(=O)Nc2cccc(Cl)c2 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":16037
  },
  {
    "COADD_ID":"CO-ADD:0257562",
    "INHIB_AVE":-1.42,
    "SMILES":"C1=C(NCc(cc2)ccc2OC)C3(OC1=O)CCCCC3",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C1=C(NCc(cc2)ccc2OC)C3(OC1=O)CCCCC3?",
    "answer":"No",
    "_id":62483
  },
  {
    "COADD_ID":"CO-ADD:0258467",
    "INHIB_AVE":-4.29,
    "SMILES":"N1(Cc2ccccc2)C(C)(O)C(OC1=O)(C)CC\\C=C(\/C)\\C",
    "HIT":0.0,
    "question":"Is N1(Cc2ccccc2)C(C)(O)C(OC1=O)(C)CC\\C=C(\/C)\\C capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":70395
  },
  {
    "COADD_ID":"CO-ADD:0255507",
    "INHIB_AVE":-2.52,
    "SMILES":"N1(c2ccc(cc2)Cl)C(=O)C(CC1=O)NCc(cc3)ccc3S(N)(=O)=O",
    "HIT":0.0,
    "question":"Can N1(c2ccc(cc2)Cl)C(=O)C(CC1=O)NCc(cc3)ccc3S(N)(=O)=O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":65863
  },
  {
    "COADD_ID":"CO-ADD:0252596",
    "INHIB_AVE":8.7,
    "SMILES":"C12(C(C)=NN(c3ccccc3)C1=O)C(C24C(C)=NN(c5ccccc5)C4=O)c(cccc6[N+](=O)[O-])c6",
    "HIT":0.0,
    "question":"Does the proposed molecule C12(C(C)=NN(c3ccccc3)C1=O)C(C24C(C)=NN(c5ccccc5)C4=O)c(cccc6[N+](=O)[O-])c6 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":20853
  },
  {
    "COADD_ID":"CO-ADD:0163211",
    "INHIB_AVE":3.6,
    "SMILES":"c1(c(O)c(\\C=N\\NC(COc2cccc(C)c2)=O)cc(c1)[N+](=O)[O-])[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Can exposure to c1(c(O)c(\\C=N\\NC(COc2cccc(C)c2)=O)cc(c1)[N+](=O)[O-])[N+](=O)[O-] lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":41954
  },
  {
    "COADD_ID":"CO-ADD:0299588",
    "INHIB_AVE":0.61,
    "SMILES":"C(=O)(NC(CO)(CO)CO)C(=O)Nc1ccccc1",
    "HIT":0.0,
    "question":"Can exposure to C(=O)(NC(CO)(CO)CO)C(=O)Nc1ccccc1 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":55060
  },
  {
    "COADD_ID":"CO-ADD:0319133",
    "INHIB_AVE":2.08,
    "SMILES":"c1(N(CC2)CCO2)scc(c(cc3)ccc3[N+](=O)[O-])n1",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(N(CC2)CCO2)scc(c(cc3)ccc3[N+](=O)[O-])n1?",
    "answer":"No",
    "_id":48744
  },
  {
    "COADD_ID":"CO-ADD:0311937",
    "INHIB_AVE":0.06,
    "SMILES":"S(=O)(=O)(N1CCCCC1)c2ccc(Br)s2",
    "HIT":0.0,
    "question":"Can S(=O)(=O)(N1CCCCC1)c2ccc(Br)s2 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":57230
  },
  {
    "COADD_ID":"CO-ADD:0158258",
    "INHIB_AVE":9.71,
    "SMILES":"O=C(N\/N=C\/C(C=CC=C1)=C1OCCCC)C2=CC=C(F)C=C2",
    "HIT":0.0,
    "question":"Can exposure to O=C(N\/N=C\/C(C=CC=C1)=C1OCCCC)C2=CC=C(F)C=C2 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":17846
  },
  {
    "COADD_ID":"CO-ADD:0137262",
    "INHIB_AVE":-12.29,
    "SMILES":"O=C([C@@](O)(CC(CO)=C[C@]([C@@]([C@@]1(C)CO)([H])[C@@]1(OC(C)=O)[C@@H]([C@H]2C)OC(CCCCCCCCCCCCCCC)=O)([H])[C@]23O)[C@]34[H])C(C)=C4",
    "HIT":0.0,
    "question":"Is O=C([C@@](O)(CC(CO)=C[C@]([C@@]([C@@]1(C)CO)([H])[C@@]1(OC(C)=O)[C@@H]([C@H]2C)OC(CCCCCCCCCCCCCCC)=O)([H])[C@]23O)[C@]34[H])C(C)=C4 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":80200
  },
  {
    "COADD_ID":"CO-ADD:0229094",
    "INHIB_AVE":102.37,
    "SMILES":"C(=O)(c1ccc(cc1)Cl)Nc(cc2)ccc2C(=O)N\\N=C\\c3cc(OC)ccc3O",
    "HIT":0.0,
    "question":"Is C(=O)(c1ccc(cc1)Cl)Nc(cc2)ccc2C(=O)N\\N=C\\c3cc(OC)ccc3O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":243
  },
  {
    "COADD_ID":"CO-ADD:0215153",
    "INHIB_AVE":18.23,
    "SMILES":"C(C(=O)N\\N=C\\c(cc1)cc(c12)ccc(OC)c2)C(=O)N\\N=C\\c(cc3)cc(c34)ccc(OC)c4",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C(C(=O)N\\N=C\\c(cc1)cc(c12)ccc(OC)c2)C(=O)N\\N=C\\c(cc3)cc(c34)ccc(OC)c4?",
    "answer":"No",
    "_id":4112
  },
  {
    "COADD_ID":"CO-ADD:0166259",
    "INHIB_AVE":0.39,
    "SMILES":"C(=O)(c1ccc(cc1)Cl)Nc2ccccc2Br",
    "HIT":0.0,
    "question":"Can C(=O)(c1ccc(cc1)Cl)Nc2ccccc2Br act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":55892
  },
  {
    "COADD_ID":"CO-ADD:0253858",
    "INHIB_AVE":1.27,
    "SMILES":"c1(cc(s2)CC)c2ncnc1O",
    "HIT":0.0,
    "question":"Can exposure to c1(cc(s2)CC)c2ncnc1O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":52270
  },
  {
    "COADD_ID":"CO-ADD:0295138",
    "INHIB_AVE":0.58,
    "SMILES":"c1(CN2CCCCC2)c(C)nc(c3c1O)ccc(OC)c3",
    "HIT":0.0,
    "question":"Is c1(CN2CCCCC2)c(C)nc(c3c1O)ccc(OC)c3 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":55167
  },
  {
    "COADD_ID":"CO-ADD:0256312",
    "INHIB_AVE":4.7,
    "SMILES":"C1(C(=O)OC(C)CC)=C(C)NC(NC1c2cccc(Oc3ccccc3)c2)=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C1(C(=O)OC(C)CC)=C(C)NC(NC1c2cccc(Oc3ccccc3)c2)=O?",
    "answer":"No",
    "_id":37017
  },
  {
    "COADD_ID":"CO-ADD:0218060",
    "INHIB_AVE":6.33,
    "SMILES":"N1(CCc(cccc2)c12)C(CCC3CCCC3)=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound N1(CCc(cccc2)c12)C(CCC3CCCC3)=O?",
    "answer":"No",
    "_id":29880
  },
  {
    "COADD_ID":"CO-ADD:0241247",
    "INHIB_AVE":4.87,
    "SMILES":"c1(c2cc(OC)c(OC)c1)C(=O)OC(c(cc3)ccc3[N+](=O)[O-])=N2",
    "HIT":0.0,
    "question":"Does treatment with c1(c2cc(OC)c(OC)c1)C(=O)OC(c(cc3)ccc3[N+](=O)[O-])=N2 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":36200
  },
  {
    "COADD_ID":"CO-ADD:0229150",
    "INHIB_AVE":0.48,
    "SMILES":"C(=O)(N\\N=C\\c1ccccc1)c2ccc(cc2)OCc3ccccc3Br",
    "HIT":0.0,
    "question":"Does C(=O)(N\\N=C\\c1ccccc1)c2ccc(cc2)OCc3ccccc3Br show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":55569
  },
  {
    "COADD_ID":"CO-ADD:0319525",
    "INHIB_AVE":5.24,
    "SMILES":"N1(O)C(C)(C)CC(NC(=O)c2ccco2)C1(C)C",
    "HIT":0.0,
    "question":"Can N1(O)C(C)(C)CC(NC(=O)c2ccco2)C1(C)C effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":34581
  },
  {
    "COADD_ID":"CO-ADD:0216929",
    "INHIB_AVE":0.32,
    "SMILES":"C(=O)(N\\N=C\\c(cc1)ccc1C(OC)=O)C(=O)Nc(ccc(c23)cccc2)c3",
    "HIT":0.0,
    "question":"Is C(=O)(N\\N=C\\c(cc1)ccc1C(OC)=O)C(=O)Nc(ccc(c23)cccc2)c3 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":56166
  },
  {
    "COADD_ID":"CO-ADD:0215804",
    "INHIB_AVE":0.4,
    "SMILES":"C(=O)(N\\N=C(\/C)\\CC(=O)NCC(C)C)C(NCCO)=O",
    "HIT":0.0,
    "question":"Does C(=O)(N\\N=C(\/C)\\CC(=O)NCC(C)C)C(NCCO)=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":55847
  },
  {
    "COADD_ID":"CO-ADD:0323051",
    "INHIB_AVE":-6.47,
    "SMILES":"P(=O)([O-])(CN(CC1)CCO1)C(Cc2ccco2)C(=O)[O-].C(=O)O",
    "HIT":0.0,
    "question":"Does P(=O)([O-])(CN(CC1)CCO1)C(Cc2ccco2)C(=O)[O-].C(=O)O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":74512
  },
  {
    "COADD_ID":"CO-ADD:0256348",
    "INHIB_AVE":18.49,
    "SMILES":"c1(NC(COC(CSc2nc(C)cc(C)n2)=O)=O)sc3c(ccc(C)c3)n1",
    "HIT":0.0,
    "question":"Is c1(NC(COC(CSc2nc(C)cc(C)n2)=O)=O)sc3c(ccc(C)c3)n1 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":3909
  },
  {
    "COADD_ID":"CO-ADD:0218542",
    "INHIB_AVE":96.96,
    "SMILES":"N1(CNc2ccccc2OC)C(=O)\\C(\\SC1=O)=C\\c3ccccc3",
    "HIT":0.0,
    "question":"Can exposure to N1(CNc2ccccc2OC)C(=O)\\C(\\SC1=O)=C\\c3ccccc3 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":332
  },
  {
    "COADD_ID":"CO-ADD:0249595",
    "INHIB_AVE":-2.16,
    "SMILES":"c1(SCC(=O)Nc(cc2)ccc2C(OC)=O)sc3c(ccc(c3)\\N=C\\c(cc(I)cc4I)c4O)n1",
    "HIT":0.0,
    "question":"Is c1(SCC(=O)Nc(cc2)ccc2C(OC)=O)sc3c(ccc(c3)\\N=C\\c(cc(I)cc4I)c4O)n1 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":64859
  },
  {
    "COADD_ID":"CO-ADD:0289208",
    "INHIB_AVE":5.6,
    "SMILES":"N(Cc(ccc(OCCN1)c2C1)c2)(c3ccc(cc3)C)C(C(C)C)=O.Cl",
    "HIT":0.0,
    "question":"Can exposure to N(Cc(ccc(OCCN1)c2C1)c2)(c3ccc(cc3)C)C(C(C)C)=O.Cl lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":32951
  },
  {
    "COADD_ID":"CO-ADD:0156410",
    "INHIB_AVE":8.07,
    "SMILES":"[O-][N+](C1=CC(\/C(C(N2)=O)=N\/NC(C3C(C4=CC=CC=C4)(C5=CC=CC=C5)C3)=O)=C2C=C1)=O",
    "HIT":0.0,
    "question":"Can [O-][N+](C1=CC(\/C(C(N2)=O)=N\/NC(C3C(C4=CC=CC=C4)(C5=CC=CC=C5)C3)=O)=C2C=C1)=O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":22971
  },
  {
    "COADD_ID":"CO-ADD:0323998",
    "INHIB_AVE":12.58,
    "SMILES":"S(NCCOC(C1)(CC(C2)CC3CC12)C3)(=O)(=O)c4ccc(c(Cl)c4OC)Cl",
    "HIT":0.0,
    "question":"Does S(NCCOC(C1)(CC(C2)CC3CC12)C3)(=O)(=O)c4ccc(c(Cl)c4OC)Cl show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":11329
  },
  {
    "COADD_ID":"CO-ADD:0136620",
    "INHIB_AVE":20.69,
    "SMILES":"c1(N)ccc(NC(=O)c2ccc(C(Nc3ccc(N)cc3)=O)cc2)cc1",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(N)ccc(NC(=O)c2ccc(C(Nc3ccc(N)cc3)=O)cc2)cc1?",
    "answer":"No",
    "_id":2481
  },
  {
    "COADD_ID":"CO-ADD:0236826",
    "INHIB_AVE":-4.69,
    "SMILES":"S(=O)(=O)(N(CC)CC)c(ccc(c1c2nnc(c3ccc(cc3)C)o2)Cl)c1",
    "HIT":0.0,
    "question":"Does S(=O)(=O)(N(CC)CC)c(ccc(c1c2nnc(c3ccc(cc3)C)o2)Cl)c1 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":71206
  },
  {
    "COADD_ID":"CO-ADD:0294297",
    "INHIB_AVE":5.57,
    "SMILES":"c1(C#N)c(SCC(=O)N(CC2)CCO2)nc(cc1C(F)(F)F)c3cccs3",
    "HIT":0.0,
    "question":"Is c1(C#N)c(SCC(=O)N(CC2)CCO2)nc(cc1C(F)(F)F)c3cccs3 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":33112
  },
  {
    "COADD_ID":"CO-ADD:0294309",
    "INHIB_AVE":-0.43,
    "SMILES":"C(C#N)(C(c(cc1)ccc1N(CC)CC)C2=C(N3c4ccc(cc4Cl)[N+](=O)[O-])CCCC2=O)=C3N",
    "HIT":0.0,
    "question":"Can C(C#N)(C(c(cc1)ccc1N(CC)CC)C2=C(N3c4ccc(cc4Cl)[N+](=O)[O-])CCCC2=O)=C3N effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":59105
  },
  {
    "COADD_ID":"CO-ADD:0242704",
    "INHIB_AVE":20.12,
    "SMILES":"C(Br)(C(OCC)=O)(C1c2ccccc2)C(C)(Br)NC(C)(Br)C1(Br)C(OCC)=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C(Br)(C(OCC)=O)(C1c2ccccc2)C(C)(Br)NC(C)(Br)C1(Br)C(OCC)=O?",
    "answer":"No",
    "_id":2809
  },
  {
    "COADD_ID":"CO-ADD:0254451",
    "INHIB_AVE":1.28,
    "SMILES":"c1(N\\N=C(\/C)\\CC(OCC)=O)nnc(C)n1N.Cl",
    "HIT":0.0,
    "question":"Does c1(N\\N=C(\/C)\\CC(OCC)=O)nnc(C)n1N.Cl demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":52263
  },
  {
    "COADD_ID":"CO-ADD:0304113",
    "INHIB_AVE":8.49,
    "SMILES":"C1(C#N)=C(C)C=C(N(CCO)C1=O)O",
    "HIT":0.0,
    "question":"Is C1(C#N)=C(C)C=C(N(CCO)C1=O)O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":21501
  },
  {
    "COADD_ID":"CO-ADD:0235594",
    "INHIB_AVE":-17.3,
    "SMILES":"S(=O)(=O)(N(CC1)CCO1)c2c(OC)ccc(c2)C(=O)Oc3ccc(cc3n4nc(c5n4)cccc5)C",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound S(=O)(=O)(N(CC1)CCO1)c2c(OC)ccc(c2)C(=O)Oc3ccc(cc3n4nc(c5n4)cccc5)C?",
    "answer":"No",
    "_id":81795
  },
  {
    "COADD_ID":"CO-ADD:0164468",
    "INHIB_AVE":-5.16,
    "SMILES":"CC1Cc2ccccc2N1NC(=O)c1ccc(Cl)c(c1)S(N)(=O)=O",
    "HIT":0.0,
    "question":"Does CC1Cc2ccccc2N1NC(=O)c1ccc(Cl)c(c1)S(N)(=O)=O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":72183
  },
  {
    "COADD_ID":"CO-ADD:0163077",
    "INHIB_AVE":6.19,
    "SMILES":"c1(C(c2ccccc2)=O)c(N)c(c3s1)ccc(C)n3",
    "HIT":0.0,
    "question":"Is c1(C(c2ccccc2)=O)c(N)c(c3s1)ccc(C)n3 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":30464
  },
  {
    "COADD_ID":"CO-ADD:0163079",
    "INHIB_AVE":2.3,
    "SMILES":"C(Nc(cccc1)c1C2(c3ccccc3)c4ccccc4)(c5cccc(OC)c5OC)O2",
    "HIT":0.0,
    "question":"Can exposure to C(Nc(cccc1)c1C2(c3ccccc3)c4ccccc4)(c5cccc(OC)c5OC)O2 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":47736
  },
  {
    "COADD_ID":"CO-ADD:0306738",
    "INHIB_AVE":1.09,
    "SMILES":"c1(C(NCCOc(cc2)ccc2CCC)=O)[nH]c(c3n1)cccc3",
    "HIT":0.0,
    "question":"Does c1(C(NCCOc(cc2)ccc2CCC)=O)[nH]c(c3n1)cccc3 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":53100
  },
  {
    "COADD_ID":"CO-ADD:0164434",
    "INHIB_AVE":98.17,
    "SMILES":"CCN1CCN(C(=O)N[C@@H](C(=O)N[C@H]2[C@H]3SC(C)(C)[C@@H](N3C2=O)C([O-])=O)c2ccccc2)C(=O)C1=O.[Na+]",
    "HIT":1.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound CCN1CCN(C(=O)N[C@@H](C(=O)N[C@H]2[C@H]3SC(C)(C)[C@@H](N3C2=O)C([O-])=O)c2ccccc2)C(=O)C1=O.[Na+]?",
    "answer":"Yes",
    "_id":185
  },
  {
    "COADD_ID":"CO-ADD:0255513",
    "INHIB_AVE":8.74,
    "SMILES":"C(=N\\NC(=O)CN(c1ccccc1C)S(C)(=O)=O)(\/c2c(N3)cccc2)\\C3=O",
    "HIT":0.0,
    "question":"Can C(=N\\NC(=O)CN(c1ccccc1C)S(C)(=O)=O)(\/c2c(N3)cccc2)\\C3=O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":20735
  },
  {
    "COADD_ID":"CO-ADD:0149061",
    "INHIB_AVE":-3.79,
    "SMILES":"c1(c2c([nH]c1)cccc2)C(=O)C(=O)Nc3cccc(F)c3",
    "HIT":0.0,
    "question":"Is c1(c2c([nH]c1)cccc2)C(=O)C(=O)Nc3cccc(F)c3 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":69264
  },
  {
    "COADD_ID":"CO-ADD:0164566",
    "INHIB_AVE":2.94,
    "SMILES":"CCOC(=O)O[C@@]1(CC[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@]12C)C(=O)OCCl",
    "HIT":0.0,
    "question":"Does CCOC(=O)O[C@@]1(CC[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@]12C)C(=O)OCCl demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":44927
  },
  {
    "COADD_ID":"CO-ADD:0301377",
    "INHIB_AVE":-0.06,
    "SMILES":"C1(C2CC(C=C2)N1C(=O)c3ccc(cc3)Cl)(C(F)(F)F)C(F)(F)F",
    "HIT":0.0,
    "question":"Can exposure to C1(C2CC(C=C2)N1C(=O)c3ccc(cc3)Cl)(C(F)(F)F)C(F)(F)F lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":57702
  },
  {
    "COADD_ID":"CO-ADD:0241468",
    "INHIB_AVE":1.52,
    "SMILES":"c1(N(C)C)nc(N\\N=C\\c(cc2)ccc2Cl)nc(Nc(cc3)ccc3F)n1.CC(=O)O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(N(C)C)nc(N\\N=C\\c(cc2)ccc2Cl)nc(Nc(cc3)ccc3F)n1.CC(=O)O?",
    "answer":"No",
    "_id":51197
  },
  {
    "COADD_ID":"CO-ADD:0283368",
    "INHIB_AVE":7.36,
    "SMILES":"c1(CN(CC2)CCO2)c3c(oc1C(OCC)=O)cccc3.Cl",
    "HIT":0.0,
    "question":"Can exposure to c1(CN(CC2)CCO2)c3c(oc1C(OCC)=O)cccc3.Cl lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":25613
  },
  {
    "COADD_ID":"CO-ADD:0291006",
    "INHIB_AVE":6.0,
    "SMILES":"C(=N\/NC(=O)c1ccc(c2c1O)cccc2)(\/c3c(N4CC)cccc3)\\C4=O",
    "HIT":0.0,
    "question":"Does C(=N\/NC(=O)c1ccc(c2c1O)cccc2)(\/c3c(N4CC)cccc3)\\C4=O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":31251
  },
  {
    "COADD_ID":"CO-ADD:0321291",
    "INHIB_AVE":-11.47,
    "SMILES":"C1(C2(C)C)=C(C(SS1)=S)c(c3N2C(=O)Nc(cc4)ccc4Cl)cc(cc3)C",
    "HIT":0.0,
    "question":"Does C1(C2(C)C)=C(C(SS1)=S)c(c3N2C(=O)Nc(cc4)ccc4Cl)cc(cc3)C show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":79699
  },
  {
    "COADD_ID":"CO-ADD:0295457",
    "INHIB_AVE":-8.28,
    "SMILES":"c1(Sc2cc(ccc2[N+](=O)[O-])N(CC3)CCO3)nncn1C",
    "HIT":0.0,
    "question":"Can c1(Sc2cc(ccc2[N+](=O)[O-])N(CC3)CCO3)nncn1C effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":77048
  },
  {
    "COADD_ID":"CO-ADD:0284634",
    "INHIB_AVE":-1.28,
    "SMILES":"c1(cn(nc1C(=O)NNC(=O)c2ccc(cc2Cl)[N+](=O)[O-])C)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(cn(nc1C(=O)NNC(=O)c2ccc(cc2Cl)[N+](=O)[O-])C)[N+](=O)[O-]?",
    "answer":"No",
    "_id":61999
  },
  {
    "COADD_ID":"CO-ADD:0299818",
    "INHIB_AVE":-10.77,
    "SMILES":"C(=C\/c1cccs1)(\/C(=O)N2C)\\C(=O)N(C2=S)C",
    "HIT":0.0,
    "question":"Can C(=C\/c1cccs1)(\/C(=O)N2C)\\C(=O)N(C2=S)C effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":79255
  },
  {
    "COADD_ID":"CO-ADD:0291078",
    "INHIB_AVE":2.41,
    "SMILES":"N1(c2ccc(cc2)Cl)C3(CCC(CC3)C(C)(C)C)Nc(c4C1=O)cccc4",
    "HIT":0.0,
    "question":"Can exposure to N1(c2ccc(cc2)Cl)C3(CCC(CC3)C(C)(C)C)Nc(c4C1=O)cccc4 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":47258
  },
  {
    "COADD_ID":"CO-ADD:0332375",
    "INHIB_AVE":4.23,
    "SMILES":"s1c(C)nnc1SCCC(=O)Nc(cc2)ccc2OC",
    "HIT":0.0,
    "question":"Does s1c(C)nnc1SCCC(=O)Nc(cc2)ccc2OC demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":39123
  },
  {
    "COADD_ID":"CO-ADD:0331833",
    "INHIB_AVE":0.81,
    "SMILES":"C(C#N)(C1=O)=C(c2ccccc2)N=C(SCC(=O)Nc3ccccc3)N1",
    "HIT":0.0,
    "question":"Does the proposed molecule C(C#N)(C1=O)=C(c2ccccc2)N=C(SCC(=O)Nc3ccccc3)N1 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":54247
  },
  {
    "COADD_ID":"CO-ADD:0162369",
    "INHIB_AVE":0.21,
    "SMILES":"n1c2c(oc1c3ccc(cc3)I)ccc(c2)\\N=C\\c4cccc(I)c4",
    "HIT":0.0,
    "question":"Can n1c2c(oc1c3ccc(cc3)I)ccc(c2)\\N=C\\c4cccc(I)c4 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":56616
  },
  {
    "COADD_ID":"CO-ADD:0285055",
    "INHIB_AVE":3.35,
    "SMILES":"N1(c2cccc(c2)C(=O)OCc3ccccc3)C(=O)C(C4C1=O)C5CC4CC5",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound N1(c2cccc(c2)C(=O)OCc3ccccc3)C(=O)C(C4C1=O)C5CC4CC5?",
    "answer":"No",
    "_id":43041
  },
  {
    "COADD_ID":"CO-ADD:0223652",
    "INHIB_AVE":-1.15,
    "SMILES":"C(COc(cc1)ccc1CCCC)(=O)N\\N=C\\c2ccccc2Cl",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C(COc(cc1)ccc1CCCC)(=O)N\\N=C\\c2ccccc2Cl?",
    "answer":"No",
    "_id":61592
  },
  {
    "COADD_ID":"CO-ADD:0329403",
    "INHIB_AVE":-0.32,
    "SMILES":"S(=O)(=O)(c1ccc(cc1)Br)N2\\C(\\SCC2)=N\\S(=O)(=O)c3ccc(cc3)Br",
    "HIT":0.0,
    "question":"Can S(=O)(=O)(c1ccc(cc1)Br)N2\\C(\\SCC2)=N\\S(=O)(=O)c3ccc(cc3)Br act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":58666
  },
  {
    "COADD_ID":"CO-ADD:0328974",
    "INHIB_AVE":5.23,
    "SMILES":"S1(CCC(C1)OC(=O)NC(=O)c2ccc(cc2)F)(=O)=O",
    "HIT":0.0,
    "question":"Can S1(CCC(C1)OC(=O)NC(=O)c2ccc(cc2)F)(=O)=O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":34625
  },
  {
    "COADD_ID":"CO-ADD:0156115",
    "INHIB_AVE":6.2,
    "SMILES":"O=C(N1C2=CC=CC=C2)C(\/N=C\/C3=CC=C(C=C3)OC(C4=CC=CC=C4)=O)=C(C)N1C",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound O=C(N1C2=CC=CC=C2)C(\/N=C\/C3=CC=C(C=C3)OC(C4=CC=CC=C4)=O)=C(C)N1C?",
    "answer":"No",
    "_id":30387
  },
  {
    "COADD_ID":"CO-ADD:0215285",
    "INHIB_AVE":17.08,
    "SMILES":"C(=N\/O)(\/Nc(cc1)ccc1OC)\\C(=N\/O)\\Nc(cc2)ccc2OC",
    "HIT":0.0,
    "question":"Is C(=N\/O)(\/Nc(cc1)ccc1OC)\\C(=N\/O)\\Nc(cc2)ccc2OC capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":5198
  },
  {
    "COADD_ID":"CO-ADD:0305803",
    "INHIB_AVE":-0.02,
    "SMILES":"c1(scc(c2ccccc2)c1C(OCC)=O)NC(=O)c3c(Cl)ccc(c3)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Does the proposed molecule c1(scc(c2ccccc2)c1C(OCC)=O)NC(=O)c3c(Cl)ccc(c3)[N+](=O)[O-] exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":57557
  },
  {
    "COADD_ID":"CO-ADD:0220450",
    "INHIB_AVE":5.1,
    "SMILES":"c(Nc(ccc(c1C)C)c1)(nc(N\\N=C\/c(cc2)ccc2Cl)nc3Nc(cc4)ccc4[N+](=O)[O-])n3",
    "HIT":0.0,
    "question":"Is c(Nc(ccc(c1C)C)c1)(nc(N\\N=C\/c(cc2)ccc2Cl)nc3Nc(cc4)ccc4[N+](=O)[O-])n3 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":35188
  },
  {
    "COADD_ID":"CO-ADD:0230667",
    "INHIB_AVE":1.37,
    "SMILES":"C(COc1ccc(cc1Br)Cl)(=O)N\\N=C\\c2ccc(cc2OC)OC",
    "HIT":0.0,
    "question":"Can C(COc1ccc(cc1Br)Cl)(=O)N\\N=C\\c2ccc(cc2OC)OC effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":51877
  },
  {
    "COADD_ID":"CO-ADD:0295571",
    "INHIB_AVE":-4.28,
    "SMILES":"S(=O)(=O)(Cc1ccccc1)c2cc(ccc2C(N)=O)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Can S(=O)(=O)(Cc1ccccc1)c2cc(ccc2C(N)=O)[N+](=O)[O-] effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":70371
  },
  {
    "COADD_ID":"CO-ADD:0284377",
    "INHIB_AVE":-6.05,
    "SMILES":"c1(C(=O)Oc2cccc(c2)\\C=N\\NC(=O)c3ccccc3OC)c(Cl)c4c(cccc4)s1",
    "HIT":0.0,
    "question":"Can c1(C(=O)Oc2cccc(c2)\\C=N\\NC(=O)c3ccccc3OC)c(Cl)c4c(cccc4)s1 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":73838
  },
  {
    "COADD_ID":"CO-ADD:0277801",
    "INHIB_AVE":-9.21,
    "SMILES":"N1(C2c3ccc(cc3)OC)C(S\\C(=C\\c(cc4)ccc4N(C)C)\\C1=O)=NC(C)=C2C(C)=O",
    "HIT":0.0,
    "question":"Is N1(C2c3ccc(cc3)OC)C(S\\C(=C\\c(cc4)ccc4N(C)C)\\C1=O)=NC(C)=C2C(C)=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":78057
  },
  {
    "COADD_ID":"CO-ADD:0329843",
    "INHIB_AVE":0.84,
    "SMILES":"c1(C(=O)N(C)C(N2C)=O)c2nc(oc(c3ccccc3)c4CC)n14",
    "HIT":0.0,
    "question":"Is c1(C(=O)N(C)C(N2C)=O)c2nc(oc(c3ccccc3)c4CC)n14 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":54136
  },
  {
    "COADD_ID":"CO-ADD:0332605",
    "INHIB_AVE":6.62,
    "SMILES":"c1(Sc(cc2)ccc2Cl)c(C=O)cc(c3n1)ccc(C)c3",
    "HIT":0.0,
    "question":"Is c1(Sc(cc2)ccc2Cl)c(C=O)cc(c3n1)ccc(C)c3 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":28611
  },
  {
    "COADD_ID":"CO-ADD:0229191",
    "INHIB_AVE":3.06,
    "SMILES":"n1(c(C)c(nn1)\\C(\\C)=N\\N)c2nonc2N",
    "HIT":0.0,
    "question":"Can n1(c(C)c(nn1)\\C(\\C)=N\\N)c2nonc2N act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":44367
  },
  {
    "COADD_ID":"CO-ADD:0323629",
    "INHIB_AVE":-6.41,
    "SMILES":"c1(c(C)[nH]n2)c2CC(C)(O)C(C(C)=O)C1c3ccc(cc3)CC",
    "HIT":0.0,
    "question":"Does treatment with c1(c(C)[nH]n2)c2CC(C)(O)C(C(C)=O)C1c3ccc(cc3)CC result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":74430
  },
  {
    "COADD_ID":"CO-ADD:0227813",
    "INHIB_AVE":-7.05,
    "SMILES":"C(OC)(=O)c1ccc(cc1)NC(CCCCCCCC(=O)Nc(cc2)ccc2C(OC)=O)=O",
    "HIT":0.0,
    "question":"Can exposure to C(OC)(=O)c1ccc(cc1)NC(CCCCCCCC(=O)Nc(cc2)ccc2C(OC)=O)=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":75406
  },
  {
    "COADD_ID":"CO-ADD:0229368",
    "INHIB_AVE":4.97,
    "SMILES":"N1(c2ccc(cc2)C)C(=O)CSC1c3ccc(cc3)Br",
    "HIT":0.0,
    "question":"Can exposure to N1(c2ccc(cc2)C)C(=O)CSC1c3ccc(cc3)Br lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":35779
  },
  {
    "COADD_ID":"CO-ADD:0311522",
    "INHIB_AVE":6.78,
    "SMILES":"C1(C(OCCSCC)=O)=C(C)NC(=O)NC1c2ccc(cc2)OC(F)(F)F",
    "HIT":0.0,
    "question":"Does treatment with C1(C(OCCSCC)=O)=C(C)NC(=O)NC1c2ccc(cc2)OC(F)(F)F result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":27916
  },
  {
    "COADD_ID":"CO-ADD:0219700",
    "INHIB_AVE":1.72,
    "SMILES":"c1(OCC(=O)N\\N=C\\c(ccc(c2Br)OC)c2)c(Br)cc(cc1Br)Br",
    "HIT":0.0,
    "question":"Does c1(OCC(=O)N\\N=C\\c(ccc(c2Br)OC)c2)c(Br)cc(cc1Br)Br show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":50348
  },
  {
    "COADD_ID":"CO-ADD:0249047",
    "INHIB_AVE":1.2,
    "SMILES":"N1(c2ccccc2C(F)(F)F)C(CCCC3=O)=C3C(C(C#N)=C1N)c4ccc(Br)s4",
    "HIT":0.0,
    "question":"Is N1(c2ccccc2C(F)(F)F)C(CCCC3=O)=C3C(C(C#N)=C1N)c4ccc(Br)s4 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":52583
  },
  {
    "COADD_ID":"CO-ADD:0220736",
    "INHIB_AVE":7.44,
    "SMILES":"c(Nc(ccc(c1C)C)c1)(nc(N\\N=C\\c(cc(Br)cc2Br)c2OC)nc3Nc(cc4)ccc4[N+](=O)[O-])n3",
    "HIT":0.0,
    "question":"Does the proposed molecule c(Nc(ccc(c1C)C)c1)(nc(N\\N=C\\c(cc(Br)cc2Br)c2OC)nc3Nc(cc4)ccc4[N+](=O)[O-])n3 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":25288
  },
  {
    "COADD_ID":"CO-ADD:0300321",
    "INHIB_AVE":9.33,
    "SMILES":"c1(cccs1)C(CCNc2c(OC)cc(c(Cl)c2)OC)=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(cccs1)C(CCNc2c(OC)cc(c(Cl)c2)OC)=O?",
    "answer":"No",
    "_id":18941
  },
  {
    "COADD_ID":"CO-ADD:0295235",
    "INHIB_AVE":4.65,
    "SMILES":"C(C(=O)c1ccc(cc1)C)(C2c3ccc(cc3)OC)=C(O)C(N2Cc(cccn4)c4)=O",
    "HIT":0.0,
    "question":"Does treatment with C(C(=O)c1ccc(cc1)C)(C2c3ccc(cc3)OC)=C(O)C(N2Cc(cccn4)c4)=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":37231
  },
  {
    "COADD_ID":"CO-ADD:0291782",
    "INHIB_AVE":-2.97,
    "SMILES":"N12C(S\\C(=C\\c(ccc3c4cc(Cl)ccc4Cl)o3)\\C1=O)=NC(C)=C(C(OCC)=O)C2c5cc(OC)ccc5OC",
    "HIT":0.0,
    "question":"Can N12C(S\\C(=C\\c(ccc3c4cc(Cl)ccc4Cl)o3)\\C1=O)=NC(C)=C(C(OCC)=O)C2c5cc(OC)ccc5OC act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":67186
  },
  {
    "COADD_ID":"CO-ADD:0302183",
    "INHIB_AVE":1.16,
    "SMILES":"c1(N(CC2)CCN2c3nc(Nc(cccc4[N+](=O)[O-])c4)nc(OC(C(F)(F)F)C(F)(F)F)n3)nc(OC(C(F)(F)F)C(F)(F)F)nc(Nc5ccccn5)n1",
    "HIT":0.0,
    "question":"Does treatment with c1(N(CC2)CCN2c3nc(Nc(cccc4[N+](=O)[O-])c4)nc(OC(C(F)(F)F)C(F)(F)F)n3)nc(OC(C(F)(F)F)C(F)(F)F)nc(Nc5ccccn5)n1 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":52816
  },
  {
    "COADD_ID":"CO-ADD:0294116",
    "INHIB_AVE":-8.45,
    "SMILES":"C1(OCC(CO1)(C)c2ccccc2)(c3c(N4CN(CC5)CCC5C(OCC)=O)cccc3)C4=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C1(OCC(CO1)(C)c2ccccc2)(c3c(N4CN(CC5)CCC5C(OCC)=O)cccc3)C4=O?",
    "answer":"No",
    "_id":77249
  },
  {
    "COADD_ID":"CO-ADD:0219058",
    "INHIB_AVE":6.39,
    "SMILES":"C(=O)(C\\C(\\C)=N\\NC(COc1ccc(cc1Cl)Cl)=O)Nc2cccc(Cl)c2C",
    "HIT":0.0,
    "question":"Does C(=O)(C\\C(\\C)=N\\NC(COc1ccc(cc1Cl)Cl)=O)Nc2cccc(Cl)c2C show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":29576
  },
  {
    "COADD_ID":"CO-ADD:0249163",
    "INHIB_AVE":-27.32,
    "SMILES":"c(c1c(s2)CCC1)(C(=O)N3c4ccccc4)c2N=C3SC(C)C(=O)Nc5c(C)cc(cc5C)C",
    "HIT":0.0,
    "question":"Does treatment with c(c1c(s2)CCC1)(C(=O)N3c4ccccc4)c2N=C3SC(C)C(=O)Nc5c(C)cc(cc5C)C result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":82540
  },
  {
    "COADD_ID":"CO-ADD:0240913",
    "INHIB_AVE":3.7,
    "SMILES":"C(=N)(N1CCCCC1)\\C(\\C#N)=N\\Nc2ccccc2F",
    "HIT":0.0,
    "question":"Does the proposed molecule C(=N)(N1CCCCC1)\\C(\\C#N)=N\\Nc2ccccc2F exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":41514
  },
  {
    "COADD_ID":"CO-ADD:0325999",
    "INHIB_AVE":7.17,
    "SMILES":"C1(S2)(N(c3ccccc3)C(=C2C(OCC)=O)C)N(c4ccccc4)N=C(C(OC)=O)S1",
    "HIT":0.0,
    "question":"Can C1(S2)(N(c3ccccc3)C(=C2C(OCC)=O)C)N(c4ccccc4)N=C(C(OC)=O)S1 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":26319
  },
  {
    "COADD_ID":"CO-ADD:0161612",
    "INHIB_AVE":-0.84,
    "SMILES":"c1(ccc(cc1Cl)Cl)C(=O)N\\N=C\\c2cccc(cccc3)c23",
    "HIT":0.0,
    "question":"Is c1(ccc(cc1Cl)Cl)C(=O)N\\N=C\\c2cccc(cccc3)c23 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":60577
  },
  {
    "COADD_ID":"CO-ADD:0136778",
    "INHIB_AVE":11.29,
    "SMILES":"C1(C(CC(=O)N1[H])SC(=S)C2C(C)=NN(c3ccccc3)C2=O)=O",
    "HIT":0.0,
    "question":"Does the proposed molecule C1(C(CC(=O)N1[H])SC(=S)C2C(C)=NN(c3ccccc3)C2=O)=O exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":13916
  },
  {
    "COADD_ID":"CO-ADD:0246069",
    "INHIB_AVE":-3.78,
    "SMILES":"s1c(SCC(=O)Nc(cc2)ccc2C)nnc1\\N=C\\N(C)C",
    "HIT":0.0,
    "question":"Can s1c(SCC(=O)Nc(cc2)ccc2C)nnc1\\N=C\\N(C)C act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":69231
  },
  {
    "COADD_ID":"CO-ADD:0225328",
    "INHIB_AVE":14.86,
    "SMILES":"C1(=N2)N(C=Cn(nc(c3cc(C)ccc3C)c4)c14)C(N2CC(=O)Nc5ccc(cc5OC)OC)=O",
    "HIT":0.0,
    "question":"Is C1(=N2)N(C=Cn(nc(c3cc(C)ccc3C)c4)c14)C(N2CC(=O)Nc5ccc(cc5OC)OC)=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":7777
  },
  {
    "COADD_ID":"CO-ADD:0324227",
    "INHIB_AVE":2.03,
    "SMILES":"c12c(n(cn1)CCC(NC(C)C)=N)C(N(C)C(=O)N2C)=O.Cl",
    "HIT":0.0,
    "question":"Does c12c(n(cn1)CCC(NC(C)C)=N)C(N(C)C(=O)N2C)=O.Cl show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":48954
  },
  {
    "COADD_ID":"CO-ADD:0277660",
    "INHIB_AVE":9.91,
    "SMILES":"c1(N(CC2)CCS2)nc(OC)nc(NCc(cccn3)c3)n1",
    "HIT":0.0,
    "question":"Does c1(N(CC2)CCS2)nc(OC)nc(NCc(cccn3)c3)n1 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":17239
  },
  {
    "COADD_ID":"CO-ADD:0310799",
    "INHIB_AVE":8.41,
    "SMILES":"c1(C2c3ccccc3OCCC)c([nH]nc1c4ccc(c(Cl)c4)Cl)OC(N)=C2C#N",
    "HIT":0.0,
    "question":"Can c1(C2c3ccccc3OCCC)c([nH]nc1c4ccc(c(Cl)c4)Cl)OC(N)=C2C#N act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":21750
  },
  {
    "COADD_ID":"CO-ADD:0244379",
    "INHIB_AVE":-7.85,
    "SMILES":"S1(=O)(=O)c2c(C(NC(CC)CC)=N1)ccc(c2)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Is S1(=O)(=O)c2c(C(NC(CC)CC)=N1)ccc(c2)[N+](=O)[O-] effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":76534
  },
  {
    "COADD_ID":"CO-ADD:0278005",
    "INHIB_AVE":5.75,
    "SMILES":"n1(CC=C)c(SCC(=O)c2cccc(cccc3)c23)nnc1c4ccc(cc4)OC",
    "HIT":0.0,
    "question":"Does the proposed molecule n1(CC=C)c(SCC(=O)c2cccc(cccc3)c23)nnc1c4ccc(cc4)OC exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":32320
  },
  {
    "COADD_ID":"CO-ADD:0305678",
    "INHIB_AVE":2.26,
    "SMILES":"C(=C(C)NC(=C1C#N)SCC(=O)Nc(cc2)ccc2CC)(C(=O)Nc3ccccc3OC)C1c4ccco4",
    "HIT":0.0,
    "question":"Does the proposed molecule C(=C(C)NC(=C1C#N)SCC(=O)Nc(cc2)ccc2CC)(C(=O)Nc3ccccc3OC)C1c4ccco4 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":47973
  },
  {
    "COADD_ID":"CO-ADD:0291592",
    "INHIB_AVE":3.44,
    "SMILES":"C1(C2C(C)CCC)=C(c3c(cccc3)OC1=O)OC(N)=C2C#N",
    "HIT":0.0,
    "question":"Does C1(C2C(C)CCC)=C(c3c(cccc3)OC1=O)OC(N)=C2C#N show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":42627
  },
  {
    "COADD_ID":"CO-ADD:0216834",
    "INHIB_AVE":2.48,
    "SMILES":"C(=O)(N\\N=C\\c(ccc(c1OCC)OCc(cc2)ccc2Cl)c1)C(NCCOC)=O",
    "HIT":0.0,
    "question":"Does the proposed molecule C(=O)(N\\N=C\\c(ccc(c1OCC)OCc(cc2)ccc2Cl)c1)C(NCCOC)=O exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":46950
  },
  {
    "COADD_ID":"CO-ADD:0136073",
    "INHIB_AVE":3.14,
    "SMILES":"c1c(NC(NCCCC)=O)c(CC)ccc1",
    "HIT":0.0,
    "question":"Does treatment with c1c(NC(NCCCC)=O)c(CC)ccc1 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":43994
  },
  {
    "COADD_ID":"CO-ADD:0236886",
    "INHIB_AVE":5.11,
    "SMILES":"C(=CC(=O)c(c12)ccc(cccc3)c13)(O2)C(F)(F)C(F)F",
    "HIT":0.0,
    "question":"Can C(=CC(=O)c(c12)ccc(cccc3)c13)(O2)C(F)(F)C(F)F act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":35159
  },
  {
    "COADD_ID":"CO-ADD:0287867",
    "INHIB_AVE":5.59,
    "SMILES":"n12c(S\\C(=C\/c(ccc3c(cc(C)c(c4[N+](=O)[O-])C)c4)o3)\\C1=O)nc(cc(C)c(C)c5)c25",
    "HIT":0.0,
    "question":"Does treatment with n12c(S\\C(=C\/c(ccc3c(cc(C)c(c4[N+](=O)[O-])C)c4)o3)\\C1=O)nc(cc(C)c(C)c5)c25 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":32995
  },
  {
    "COADD_ID":"CO-ADD:0162453",
    "INHIB_AVE":4.19,
    "SMILES":"N(CC1)(CCN1C(=O)COc(cc2)ccc2C)C(OCC)=O",
    "HIT":0.0,
    "question":"Does N(CC1)(CCN1C(=O)COc(cc2)ccc2C)C(OCC)=O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":39301
  },
  {
    "COADD_ID":"CO-ADD:0259289",
    "INHIB_AVE":4.65,
    "SMILES":"c(C(=O)c(cc1)ccc1[N+](=O)[O-])(sc(c23)nc(c(C)c2C)C)c3N",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c(C(=O)c(cc1)ccc1[N+](=O)[O-])(sc(c23)nc(c(C)c2C)C)c3N?",
    "answer":"No",
    "_id":37236
  },
  {
    "COADD_ID":"CO-ADD:0321158",
    "INHIB_AVE":-0.16,
    "SMILES":"C(\/Oc(c12)cc(c3c1)OCO3)(\\S2)=C(\\C(OC)=O)\/C(F)(F)F",
    "HIT":0.0,
    "question":"Does the proposed molecule C(\/Oc(c12)cc(c3c1)OCO3)(\\S2)=C(\\C(OC)=O)\/C(F)(F)F exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":58080
  },
  {
    "COADD_ID":"CO-ADD:0136244",
    "INHIB_AVE":1.77,
    "SMILES":"n1([H])c(C(O)=O)cc(cc(OCc(cccc2)c2)c3)c1c3",
    "HIT":0.0,
    "question":"Does treatment with n1([H])c(C(O)=O)cc(cc(OCc(cccc2)c2)c3)c1c3 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":50131
  },
  {
    "COADD_ID":"CO-ADD:0161179",
    "INHIB_AVE":0.23,
    "SMILES":"C(\/NC(c1ccccc1)=O)(\\C(=O)N\\N=C\\c2cc(Cl)ccc2OC)=C\\c3cccs3",
    "HIT":0.0,
    "question":"Can exposure to C(\/NC(c1ccccc1)=O)(\\C(=O)N\\N=C\\c2cc(Cl)ccc2OC)=C\\c3cccs3 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":56538
  },
  {
    "COADD_ID":"CO-ADD:0162535",
    "INHIB_AVE":7.03,
    "SMILES":"C(=C\\c(cc1)ccc1N(CC2)CCO2)(\/C(=O)NC(N3)=O)\\C3=O",
    "HIT":0.0,
    "question":"Can exposure to C(=C\\c(cc1)ccc1N(CC2)CCO2)(\/C(=O)NC(N3)=O)\\C3=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":26858
  },
  {
    "COADD_ID":"CO-ADD:0236312",
    "INHIB_AVE":6.31,
    "SMILES":"N1(c2ccc(cc2)Cl)C(=O)CC(N(CC3)CCC3C(N)=O)C1=O",
    "HIT":0.0,
    "question":"Can N1(c2ccc(cc2)Cl)C(=O)CC(N(CC3)CCC3C(N)=O)C1=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":29949
  },
  {
    "COADD_ID":"CO-ADD:0244431",
    "INHIB_AVE":4.91,
    "SMILES":"c(cc1)(ccc1OCCN)F.Cl",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c(cc1)(ccc1OCCN)F.Cl?",
    "answer":"No",
    "_id":36031
  },
  {
    "COADD_ID":"CO-ADD:0301604",
    "INHIB_AVE":2.28,
    "SMILES":"c1(C(OCC)=O)c(cc(OC)c(c2)Br)c2n(C)c1CN3CCCC3",
    "HIT":0.0,
    "question":"Does treatment with c1(C(OCC)=O)c(cc(OC)c(c2)Br)c2n(C)c1CN3CCCC3 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":47872
  },
  {
    "COADD_ID":"CO-ADD:0249894",
    "INHIB_AVE":18.72,
    "SMILES":"s1c(C(C)(C)C)nnc1NC(=O)c(cc2)ccc2C(C)(C)C",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound s1c(C(C)(C)C)nnc1NC(=O)c(cc2)ccc2C(C)(C)C?",
    "answer":"No",
    "_id":3741
  },
  {
    "COADD_ID":"CO-ADD:0247366",
    "INHIB_AVE":7.62,
    "SMILES":"c1(SCC(=O)c2ccc(cc2)F)sc3c(ccc(OCC)c3)n1",
    "HIT":0.0,
    "question":"Can c1(SCC(=O)c2ccc(cc2)F)sc3c(ccc(OCC)c3)n1 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":24584
  },
  {
    "COADD_ID":"CO-ADD:0303516",
    "INHIB_AVE":40.51,
    "SMILES":"C(C(OC)=O)(=CN(Cc(cc1)ccc1OC)C=C2C(OC)=O)C2c3cccs3",
    "HIT":0.0,
    "question":"Is C(C(OC)=O)(=CN(Cc(cc1)ccc1OC)C=C2C(OC)=O)C2c3cccs3 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":543
  },
  {
    "COADD_ID":"CO-ADD:0226672",
    "INHIB_AVE":52.68,
    "SMILES":"c1(C2=O)n(c(nn1)CC)c3c(cccc3)N2CC(=O)Nc4ccc(cc4F)Br",
    "HIT":0.0,
    "question":"Is c1(C2=O)n(c(nn1)CC)c3c(cccc3)N2CC(=O)Nc4ccc(cc4F)Br effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":469
  },
  {
    "COADD_ID":"CO-ADD:0286896",
    "INHIB_AVE":0.64,
    "SMILES":"C12(c(cccc3)c3C(c4ccc(cc4)Cl)(c5ccc(cc5)Cl)S1)N(c6ccc(cc6)Br)N=C(C(OCC)=O)S2",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C12(c(cccc3)c3C(c4ccc(cc4)Cl)(c5ccc(cc5)Cl)S1)N(c6ccc(cc6)Br)N=C(C(OCC)=O)S2?",
    "answer":"No",
    "_id":54923
  },
  {
    "COADD_ID":"CO-ADD:0243297",
    "INHIB_AVE":1.46,
    "SMILES":"c1(OC(N)=C(C2c(cc(c3c4OCO3)OC)c4)C#N)c2c([nH]n1)CC",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(OC(N)=C(C2c(cc(c3c4OCO3)OC)c4)C#N)c2c([nH]n1)CC?",
    "answer":"No",
    "_id":51472
  },
  {
    "COADD_ID":"CO-ADD:0284837",
    "INHIB_AVE":7.32,
    "SMILES":"C(C(OCC)=O)(C(F)(F)F)(NC(=O)c1ccc(cc1)F)Nc2nc(cccc3)c3nc2C(F)(F)F",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C(C(OCC)=O)(C(F)(F)F)(NC(=O)c1ccc(cc1)F)Nc2nc(cccc3)c3nc2C(F)(F)F?",
    "answer":"No",
    "_id":25799
  },
  {
    "COADD_ID":"CO-ADD:0217883",
    "INHIB_AVE":96.78,
    "SMILES":"c1(ccc(\\C=N\\c(cccc2NC(C)=O)c2)s1)[N+](=O)[O-]",
    "HIT":1.0,
    "question":"Does c1(ccc(\\C=N\\c(cccc2NC(C)=O)c2)s1)[N+](=O)[O-] show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"Yes",
    "_id":120
  },
  {
    "COADD_ID":"CO-ADD:0223233",
    "INHIB_AVE":4.84,
    "SMILES":"c1(O)c(OCC)cc(cc1Cl)\\C=N\\NC(COc2c(C)cccc2C)=O",
    "HIT":0.0,
    "question":"Does the proposed molecule c1(O)c(OCC)cc(cc1Cl)\\C=N\\NC(COc2c(C)cccc2C)=O exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":36346
  },
  {
    "COADD_ID":"CO-ADD:0277981",
    "INHIB_AVE":16.74,
    "SMILES":"c1(nnc(C)s1)NC(=O)C(CC)OC(=O)C(CCSC)NC(c2ccccc2)=O",
    "HIT":0.0,
    "question":"Does treatment with c1(nnc(C)s1)NC(=O)C(CC)OC(=O)C(CCSC)NC(c2ccccc2)=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":5541
  },
  {
    "COADD_ID":"CO-ADD:0218393",
    "INHIB_AVE":4.99,
    "SMILES":"c1(non2)c2nc(Nc3cc(C)ccc3C)c(N\\N=C\\c4ccc(cc4Cl)Cl)n1",
    "HIT":0.0,
    "question":"Is c1(non2)c2nc(Nc3cc(C)ccc3C)c(N\\N=C\\c4ccc(cc4Cl)Cl)n1 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":35674
  },
  {
    "COADD_ID":"CO-ADD:0331495",
    "INHIB_AVE":-1.86,
    "SMILES":"C1(C2(C)C)=C(C(SS1)=S)c(c3N2C(=O)CSC(=NN(C4=S)c5ccccc5)S4)cc(cc3)C",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C1(C2(C)C)=C(C(SS1)=S)c(c3N2C(=O)CSC(=NN(C4=S)c5ccccc5)S4)cc(cc3)C?",
    "answer":"No",
    "_id":63922
  },
  {
    "COADD_ID":"CO-ADD:0162195",
    "INHIB_AVE":-7.56,
    "SMILES":"C(COc(cc1)ccc1CCCC)(=O)N\\N=C\\c2cccc(OC)c2OC",
    "HIT":0.0,
    "question":"Can exposure to C(COc(cc1)ccc1CCCC)(=O)N\\N=C\\c2cccc(OC)c2OC lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":76150
  },
  {
    "COADD_ID":"CO-ADD:0161518",
    "INHIB_AVE":4.15,
    "SMILES":"c1(C(=O)N\\N=C\\c(cc2)ccc2F)nc(c3ccccc3)cc(c4ccccc4)n1",
    "HIT":0.0,
    "question":"Can c1(C(=O)N\\N=C\\c(cc2)ccc2F)nc(c3ccccc3)cc(c4ccccc4)n1 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":39480
  },
  {
    "COADD_ID":"CO-ADD:0332379",
    "INHIB_AVE":4.22,
    "SMILES":"c(c1c(s2)CCCC1)(C3=O)c2N=C(C)N3NC(=O)c4ccc(cc4)C",
    "HIT":0.0,
    "question":"Does c(c1c(s2)CCCC1)(C3=O)c2N=C(C)N3NC(=O)c4ccc(cc4)C demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":39150
  },
  {
    "COADD_ID":"CO-ADD:0160430",
    "INHIB_AVE":8.07,
    "SMILES":"FC(C(NC1=CC=CC(Br)=C1)=O)(C(F)(F)F)OC(F)(F)C(F)(F)C(F)(F)F",
    "HIT":0.0,
    "question":"Can FC(C(NC1=CC=CC(Br)=C1)=O)(C(F)(F)F)OC(F)(F)C(F)(F)C(F)(F)F effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":22932
  },
  {
    "COADD_ID":"CO-ADD:0222464",
    "INHIB_AVE":17.01,
    "SMILES":"N(\/c1cccc(Cl)c1Cl)=C\\c2ccc(cc2Cl)Cl",
    "HIT":0.0,
    "question":"Is N(\/c1cccc(Cl)c1Cl)=C\\c2ccc(cc2Cl)Cl capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":5284
  },
  {
    "COADD_ID":"CO-ADD:0320960",
    "INHIB_AVE":2.09,
    "SMILES":"n(c1OCC(F)(F)F)c(OCC(F)(F)F)nc(NCCOC(CC(CC2C3)CC34)(C4)C2)n1",
    "HIT":0.0,
    "question":"Does treatment with n(c1OCC(F)(F)F)c(OCC(F)(F)F)nc(NCCOC(CC(CC2C3)CC34)(C4)C2)n1 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":48707
  },
  {
    "COADD_ID":"CO-ADD:0257846",
    "INHIB_AVE":-2.89,
    "SMILES":"N1(C2c3ccc(cc3)Cl)C(S\\C(=C\\c(cc(n4c5ccc(cc5)Cl)C)c4C)\\C1=O)=NC(C)=C2C(OCC)=O",
    "HIT":0.0,
    "question":"Does treatment with N1(C2c3ccc(cc3)Cl)C(S\\C(=C\\c(cc(n4c5ccc(cc5)Cl)C)c4C)\\C1=O)=NC(C)=C2C(OCC)=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":66965
  },
  {
    "COADD_ID":"CO-ADD:0158335",
    "INHIB_AVE":-5.05,
    "SMILES":"O=C(\/C1=C\\C2=CC(OC)=C(C(Cl)=C2)O)N(N=C1C)C3=CC=C(Cl)C=C3",
    "HIT":0.0,
    "question":"Can O=C(\/C1=C\\C2=CC(OC)=C(C(Cl)=C2)O)N(N=C1C)C3=CC=C(Cl)C=C3 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":71955
  },
  {
    "COADD_ID":"CO-ADD:0228026",
    "INHIB_AVE":13.51,
    "SMILES":"c1(c2ccc(cc2)Cl)ccc(\\C=N\\NC(CNC(=O)c(cc3OC)cc(c3OC)OC)=O)o1",
    "HIT":0.0,
    "question":"Is c1(c2ccc(cc2)Cl)ccc(\\C=N\\NC(CNC(=O)c(cc3OC)cc(c3OC)OC)=O)o1 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":9749
  },
  {
    "COADD_ID":"CO-ADD:0242567",
    "INHIB_AVE":10.76,
    "SMILES":"C1(C(=O)NNC(=O)c(cc2)ccc2[N+](=O)[O-])=Cc(cccc3CC=C)c3OC1=O",
    "HIT":0.0,
    "question":"Can C1(C(=O)NNC(=O)c(cc2)ccc2[N+](=O)[O-])=Cc(cccc3CC=C)c3OC1=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":15097
  },
  {
    "COADD_ID":"CO-ADD:0283659",
    "INHIB_AVE":-1.44,
    "SMILES":"N1(CC(CC1=O)C(O)=O)c2ccccc2C(C)C",
    "HIT":0.0,
    "question":"Does N1(CC(CC1=O)C(O)=O)c2ccccc2C(C)C show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":62572
  },
  {
    "COADD_ID":"CO-ADD:0255632",
    "INHIB_AVE":2.6,
    "SMILES":"S(=O)(=O)(c1ccc(cc1)C)N(c2cccc(Cl)c2)CC(=O)Nc3cccc(Cl)c3Cl",
    "HIT":0.0,
    "question":"Does S(=O)(=O)(c1ccc(cc1)C)N(c2cccc(Cl)c2)CC(=O)Nc3cccc(Cl)c3Cl demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":46423
  },
  {
    "COADD_ID":"CO-ADD:0324563",
    "INHIB_AVE":4.05,
    "SMILES":"C(CCNC(=S)Nc(cc1)ccc1Cl)(C2)(C3)CC(CC3C4)CC24",
    "HIT":0.0,
    "question":"Is C(CCNC(=S)Nc(cc1)ccc1Cl)(C2)(C3)CC(CC3C4)CC24 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":39910
  },
  {
    "COADD_ID":"CO-ADD:0293016",
    "INHIB_AVE":-10.63,
    "SMILES":"c(c(N)c1N)c(OCCO2)c2c1",
    "HIT":0.0,
    "question":"Is c(c(N)c1N)c(OCCO2)c2c1 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":79164
  },
  {
    "COADD_ID":"CO-ADD:0259563",
    "INHIB_AVE":-14.38,
    "SMILES":"n1(c2c(nc1SCC(OCC)=O)cccc2)C(OCCCC)=O",
    "HIT":0.0,
    "question":"Does n1(c2c(nc1SCC(OCC)=O)cccc2)C(OCCCC)=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":81105
  },
  {
    "COADD_ID":"CO-ADD:0303718",
    "INHIB_AVE":4.28,
    "SMILES":"N1C(c(cc2)ccc2N(CC)CC)Nc(c3C1=O)cccc3",
    "HIT":0.0,
    "question":"Does treatment with N1C(c(cc2)ccc2N(CC)CC)Nc(c3C1=O)cccc3 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":38903
  },
  {
    "COADD_ID":"CO-ADD:0164383",
    "INHIB_AVE":-0.56,
    "SMILES":"CCCCCCCCCOc1ccc2[nH]cc(CCN)c2c1.Cl",
    "HIT":0.0,
    "question":"Is CCCCCCCCCOc1ccc2[nH]cc(CCN)c2c1.Cl effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":59598
  },
  {
    "COADD_ID":"CO-ADD:0324700",
    "INHIB_AVE":2.03,
    "SMILES":"N(CC1N2CCc(cccc3)c13)(C2c4ccc(c(OCC)c4)OC)S(=O)(=O)c5ccc(cc5)C",
    "HIT":0.0,
    "question":"Can N(CC1N2CCc(cccc3)c13)(C2c4ccc(c(OCC)c4)OC)S(=O)(=O)c5ccc(cc5)C effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":48980
  },
  {
    "COADD_ID":"CO-ADD:0158120",
    "INHIB_AVE":4.18,
    "SMILES":"O=C(N\/N=C\/C1=CC(OC)=C(OCC=C)C=C1)C(N2CCCCC2)=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound O=C(N\/N=C\/C1=CC(OC)=C(OCC=C)C=C1)C(N2CCCCC2)=O?",
    "answer":"No",
    "_id":39338
  },
  {
    "COADD_ID":"CO-ADD:0243414",
    "INHIB_AVE":3.12,
    "SMILES":"c(OC1)(c(OC)c([N+](=O)[O-])c2C#N)c(O1)c2OC",
    "HIT":0.0,
    "question":"Does c(OC1)(c(OC)c([N+](=O)[O-])c2C#N)c(O1)c2OC show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":44082
  },
  {
    "COADD_ID":"CO-ADD:0295331",
    "INHIB_AVE":1.84,
    "SMILES":"C(=O)(Oc1ccccc1C=O)c2c(cccc2F)F",
    "HIT":0.0,
    "question":"Can exposure to C(=O)(Oc1ccccc1C=O)c2c(cccc2F)F lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":49822
  },
  {
    "COADD_ID":"CO-ADD:0293996",
    "INHIB_AVE":-6.15,
    "SMILES":"c1(cc(C#N)c(cc1N(CC2)CCN2c3cc(C#N)c(cc3[N+](=O)[O-])C#N)C#N)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Does the proposed molecule c1(cc(C#N)c(cc1N(CC2)CCN2c3cc(C#N)c(cc3[N+](=O)[O-])C#N)C#N)[N+](=O)[O-] exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":74009
  },
  {
    "COADD_ID":"CO-ADD:0324243",
    "INHIB_AVE":-0.3,
    "SMILES":"c1(c(OC)cc(c2c1)cccc2)C(=O)NCC(CC(CC3C4)CC45)(C5)C3",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(c(OC)cc(c2c1)cccc2)C(=O)NCC(CC(CC3C4)CC45)(C5)C3?",
    "answer":"No",
    "_id":58585
  },
  {
    "COADD_ID":"CO-ADD:0295345",
    "INHIB_AVE":-0.41,
    "SMILES":"C(=O)(C(C)(C)Br)Nc1ccc(c(OC)c1)OC",
    "HIT":0.0,
    "question":"Is C(=O)(C(C)(C)Br)Nc1ccc(c(OC)c1)OC effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":59054
  },
  {
    "COADD_ID":"CO-ADD:0229354",
    "INHIB_AVE":10.24,
    "SMILES":"c1(SCC=C)sc2c(ccc(c2)\\N=C\\c(ccc3I)o3)n1",
    "HIT":0.0,
    "question":"Does treatment with c1(SCC=C)sc2c(ccc(c2)\\N=C\\c(ccc3I)o3)n1 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":16392
  },
  {
    "COADD_ID":"CO-ADD:0286576",
    "INHIB_AVE":0.59,
    "SMILES":"C(c(cc1)cc(c1[N+](=O)[O-])C)(O2)=Nc(c3C2=O)ccc(OC(C)=O)c3",
    "HIT":0.0,
    "question":"Does treatment with C(c(cc1)cc(c1[N+](=O)[O-])C)(O2)=Nc(c3C2=O)ccc(OC(C)=O)c3 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":55146
  },
  {
    "COADD_ID":"CO-ADD:0321471",
    "INHIB_AVE":9.08,
    "SMILES":"c1(c2c(cs1)CCCC2)C(=O)Nc3ccccc3",
    "HIT":0.0,
    "question":"Is c1(c2c(cs1)CCCC2)C(=O)Nc3ccccc3 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":19636
  },
  {
    "COADD_ID":"CO-ADD:0234878",
    "INHIB_AVE":6.37,
    "SMILES":"C(=O)(c1cccc(OC)c1)Oc2ccc(cc2OC)\\C=N\\NC(=O)Cc3cccc(cccc4)c34",
    "HIT":0.0,
    "question":"Is C(=O)(c1cccc(OC)c1)Oc2ccc(cc2OC)\\C=N\\NC(=O)Cc3cccc(cccc4)c34 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":29697
  },
  {
    "COADD_ID":"CO-ADD:0235787",
    "INHIB_AVE":14.97,
    "SMILES":"N(=C\\c(ccc(c1OC)OC)c1)\/NC(CCC(=O)Nc(cc2)ccc2F)=O",
    "HIT":0.0,
    "question":"Does N(=C\\c(ccc(c1OC)OC)c1)\/NC(CCC(=O)Nc(cc2)ccc2F)=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":7636
  },
  {
    "COADD_ID":"CO-ADD:0240181",
    "INHIB_AVE":4.92,
    "SMILES":"N(\/c(ccc(c1C)C)c1)=C\\c(ccc(c2O)OC)c2",
    "HIT":0.0,
    "question":"Does the proposed molecule N(\/c(ccc(c1C)C)c1)=C\\c(ccc(c2O)OC)c2 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":35972
  },
  {
    "COADD_ID":"CO-ADD:0235898",
    "INHIB_AVE":13.44,
    "SMILES":"c(N)(c(Br)c1)c(Br)cc1C(=O)OCC(=O)c2ccc(cc2)Br",
    "HIT":0.0,
    "question":"Does c(N)(c(Br)c1)c(Br)cc1C(=O)OCC(=O)c2ccc(cc2)Br demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":9853
  },
  {
    "COADD_ID":"CO-ADD:0293360",
    "INHIB_AVE":-0.38,
    "SMILES":"C12=C(CC(c3ccccc3)CC1=O)Nc(c4NC2c5ccccc5Br)cccc4",
    "HIT":0.0,
    "question":"Does the proposed molecule C12=C(CC(c3ccccc3)CC1=O)Nc(c4NC2c5ccccc5Br)cccc4 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":58928
  },
  {
    "COADD_ID":"CO-ADD:0241298",
    "INHIB_AVE":-3.77,
    "SMILES":"C1(=S)N(c2ccccc2)C3(\\C(=N\\c4cccc(C)c4)\\N1)CCCCC3",
    "HIT":0.0,
    "question":"Can C1(=S)N(c2ccccc2)C3(\\C(=N\\c4cccc(C)c4)\\N1)CCCCC3 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":69207
  },
  {
    "COADD_ID":"CO-ADD:0278642",
    "INHIB_AVE":0.89,
    "SMILES":"C(CC(C)(C)CC1=O)(Nc(ccc(c23)OCO2)c3)=C1",
    "HIT":0.0,
    "question":"Does C(CC(C)(C)CC1=O)(Nc(ccc(c23)OCO2)c3)=C1 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":53918
  },
  {
    "COADD_ID":"CO-ADD:0227403",
    "INHIB_AVE":10.07,
    "SMILES":"c1(ccc(cc1OC)OC)\\C(\\C)=N\\NC(CNc2cccc(C)c2)=O",
    "HIT":0.0,
    "question":"Can c1(ccc(cc1OC)OC)\\C(\\C)=N\\NC(CNc2cccc(C)c2)=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":16809
  },
  {
    "COADD_ID":"CO-ADD:0259690",
    "INHIB_AVE":14.5,
    "SMILES":"S(C)(=O)(=O)N(Cc(cc1)ccc1C(=O)N\\N=C(\/C2)\\CCCC2)c3ccc(c(C)c3)C",
    "HIT":0.0,
    "question":"Does S(C)(=O)(=O)N(Cc(cc1)ccc1C(=O)N\\N=C(\/C2)\\CCCC2)c3ccc(c(C)c3)C demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":8257
  },
  {
    "COADD_ID":"CO-ADD:0240093",
    "INHIB_AVE":3.12,
    "SMILES":"C=C1[C@]([C@]([H])(C2=CC=CC=C2)NC3=CC=C(Br)C=C3)([H])CC(COC)(COC)C1",
    "HIT":0.0,
    "question":"Does the proposed molecule C=C1[C@]([C@]([H])(C2=CC=CC=C2)NC3=CC=C(Br)C=C3)([H])CC(COC)(COC)C1 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":44092
  },
  {
    "COADD_ID":"CO-ADD:0227116",
    "INHIB_AVE":8.38,
    "SMILES":"c12n(c(c3s1)ccc(c3)C(OCC)=O)cc(c4ccc(cc4)Br)n2",
    "HIT":0.0,
    "question":"Can exposure to c12n(c(c3s1)ccc(c3)C(OCC)=O)cc(c4ccc(cc4)Br)n2 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":21859
  },
  {
    "COADD_ID":"CO-ADD:0220879",
    "INHIB_AVE":16.7,
    "SMILES":"n1c(N(C)C)nc(nc1N(CC2)CCO2)N\\N=C(\/C)\\c(cc3)ccc3[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Does the proposed molecule n1c(N(C)C)nc(nc1N(CC2)CCO2)N\\N=C(\/C)\\c(cc3)ccc3[N+](=O)[O-] exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":5580
  },
  {
    "COADD_ID":"CO-ADD:0320488",
    "INHIB_AVE":12.39,
    "SMILES":"c1(n2)c(C(N(C)C(=O)N1C)=O)n(c23)CC(=NN3Cc4ccccc4)C56CC(CC7C5)CC(C7)C6",
    "HIT":0.0,
    "question":"Is c1(n2)c(C(N(C)C(=O)N1C)=O)n(c23)CC(=NN3Cc4ccccc4)C56CC(CC7C5)CC(C7)C6 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":11672
  },
  {
    "COADD_ID":"CO-ADD:0329411",
    "INHIB_AVE":59.56,
    "SMILES":"C(C(O)=O)(=CN1CC)C(=O)c(c12)cnc(N(CC3)CCN3C(=S)NC(=O)c(ccc(n4)Cl)c4)n2",
    "HIT":1.0,
    "question":"Is C(C(O)=O)(=CN1CC)C(=O)c(c12)cnc(N(CC3)CCN3C(=S)NC(=O)c(ccc(n4)Cl)c4)n2 effective in eliminating E. coli under experimental conditions?",
    "answer":"Yes",
    "_id":176
  },
  {
    "COADD_ID":"CO-ADD:0228061",
    "INHIB_AVE":15.06,
    "SMILES":"n(Cc1ccccc1)(c2c(c3\\C=N\\NC(CNc4ccccc4C)=O)cccc2)c3",
    "HIT":0.0,
    "question":"Does the proposed molecule n(Cc1ccccc1)(c2c(c3\\C=N\\NC(CNc4ccccc4C)=O)cccc2)c3 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":7522
  },
  {
    "COADD_ID":"CO-ADD:0234946",
    "INHIB_AVE":-1.95,
    "SMILES":"c1(cc(cc(OC)c1OCC(=O)N\\N=C\\c(ccc2c3ccc(cc3Cl)Cl)o2)[N+](=O)[O-])[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Can c1(cc(cc(OC)c1OCC(=O)N\\N=C\\c(ccc2c3ccc(cc3Cl)Cl)o2)[N+](=O)[O-])[N+](=O)[O-] effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":64211
  },
  {
    "COADD_ID":"CO-ADD:0253196",
    "INHIB_AVE":10.32,
    "SMILES":"C1(C(=O)OC2CCCCCC2)=C(C)NC(NC1c3cccc(OC)c3OC)=O",
    "HIT":0.0,
    "question":"Does the proposed molecule C1(C(=O)OC2CCCCCC2)=C(C)NC(NC1c3cccc(OC)c3OC)=O exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":16184
  },
  {
    "COADD_ID":"CO-ADD:0321406",
    "INHIB_AVE":-3.06,
    "SMILES":"s1c(SCC(=O)Nc(cc2)ccc2OC(F)(F)F)nnc1SCC(=O)Nc(cc3)ccc3OC(F)(F)F",
    "HIT":0.0,
    "question":"Does s1c(SCC(=O)Nc(cc2)ccc2OC(F)(F)F)nnc1SCC(=O)Nc(cc3)ccc3OC(F)(F)F demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":67398
  },
  {
    "COADD_ID":"CO-ADD:0136652",
    "INHIB_AVE":19.93,
    "SMILES":"N1(CC(O)COc(cc(C)cc2)c2)CCN(CC1)c(ccc(C)c3)c3",
    "HIT":0.0,
    "question":"Does N1(CC(O)COc(cc(C)cc2)c2)CCN(CC1)c(ccc(C)c3)c3 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":2919
  },
  {
    "COADD_ID":"CO-ADD:0155265",
    "INHIB_AVE":2.2,
    "SMILES":"O=C1CN(C(C2=CC=CC=C2)=O)C(C(C(Cl)=C3)=CC=C3Cl)N1OC",
    "HIT":0.0,
    "question":"Can exposure to O=C1CN(C(C2=CC=CC=C2)=O)C(C(C(Cl)=C3)=CC=C3Cl)N1OC lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":48223
  },
  {
    "COADD_ID":"CO-ADD:0228723",
    "INHIB_AVE":-5.68,
    "SMILES":"c(cc(C(OCC)=O)c(n1)C)(c12)\\C(=N\\C3CCCCC3)\\c4c2cccc4",
    "HIT":0.0,
    "question":"Does c(cc(C(OCC)=O)c(n1)C)(c12)\\C(=N\\C3CCCCC3)\\c4c2cccc4 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":73135
  },
  {
    "COADD_ID":"CO-ADD:0327186",
    "INHIB_AVE":6.66,
    "SMILES":"N1(c2ccc(cc2)F)C(c3ccccc3)C(=C(Nc(cc4)ccc4F)C1=O)CC(O)=O",
    "HIT":0.0,
    "question":"Does the proposed molecule N1(c2ccc(cc2)F)C(c3ccccc3)C(=C(Nc(cc4)ccc4F)C1=O)CC(O)=O exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":28460
  },
  {
    "COADD_ID":"CO-ADD:0156124",
    "INHIB_AVE":6.22,
    "SMILES":"O=C(N\/N=C\/C1=CC=C2OCOC2=C1)C(NC(C=CC=C3)=C3Cl)=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound O=C(N\/N=C\/C1=CC=C2OCOC2=C1)C(NC(C=CC=C3)=C3Cl)=O?",
    "answer":"No",
    "_id":30334
  },
  {
    "COADD_ID":"CO-ADD:0156306",
    "INHIB_AVE":-5.34,
    "SMILES":"O=C(COC1=C(Br)C=C(OC)C=C1)N\/N=C\/C2=CC=C(OCC=C)C=C2",
    "HIT":0.0,
    "question":"Is O=C(COC1=C(Br)C=C(OC)C=C1)N\/N=C\/C2=CC=C(OCC=C)C=C2 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":72533
  },
  {
    "COADD_ID":"CO-ADD:0329512",
    "INHIB_AVE":7.05,
    "SMILES":"C(C(F)(F)F)(C(F)(F)F)(Nc1sc2c(ccc(c2)OC(F)(F)F)n1)NC(=O)c3cccc(OC)c3",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C(C(F)(F)F)(C(F)(F)F)(Nc1sc2c(ccc(c2)OC(F)(F)F)n1)NC(=O)c3cccc(OC)c3?",
    "answer":"No",
    "_id":26790
  },
  {
    "COADD_ID":"CO-ADD:0323168",
    "INHIB_AVE":12.57,
    "SMILES":"c(N1CCCCC1C)(nc(Cl)nc2N3CCCCC3C)n2",
    "HIT":0.0,
    "question":"Is c(N1CCCCC1C)(nc(Cl)nc2N3CCCCC3C)n2 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":11359
  },
  {
    "COADD_ID":"CO-ADD:0166355",
    "INHIB_AVE":10.47,
    "SMILES":"C(=O)(N\\N=C\\c1c(O)ccc(cccc2)c12)C(=O)NCC3CCCO3",
    "HIT":0.0,
    "question":"Can C(=O)(N\\N=C\\c1c(O)ccc(cccc2)c12)C(=O)NCC3CCCO3 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":15804
  },
  {
    "COADD_ID":"CO-ADD:0220905",
    "INHIB_AVE":-4.75,
    "SMILES":"c1(cc(Br)ccc1O)C(=O)N\\N=C\\c2ccccc2OCC(O)=O",
    "HIT":0.0,
    "question":"Is c1(cc(Br)ccc1O)C(=O)N\\N=C\\c2ccccc2OCC(O)=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":71327
  },
  {
    "COADD_ID":"CO-ADD:0235985",
    "INHIB_AVE":-3.59,
    "SMILES":"C1(N(c2ccccc2)CCN1c3ccccc3)c4ccc(Br)s4",
    "HIT":0.0,
    "question":"Is C1(N(c2ccccc2)CCN1c3ccccc3)c4ccc(Br)s4 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":68759
  },
  {
    "COADD_ID":"CO-ADD:0160074",
    "INHIB_AVE":6.19,
    "SMILES":"O=C1N(C2=CC(C(NC3=CC(C=CC=C4)=C4C=C3)=O)=CC=C2)C(C5C6C7=C(C=CC=C7)C(C8=C6C=CC=C8)C15)=O",
    "HIT":0.0,
    "question":"Is O=C1N(C2=CC(C(NC3=CC(C=CC=C4)=C4C=C3)=O)=CC=C2)C(C5C6C7=C(C=CC=C7)C(C8=C6C=CC=C8)C15)=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":30452
  },
  {
    "COADD_ID":"CO-ADD:0286673",
    "INHIB_AVE":9.48,
    "SMILES":"c1(C(=O)N(C)C)c2c(sc1NC(=O)c3cccc(C)c3)CCCCC2",
    "HIT":0.0,
    "question":"Is c1(C(=O)N(C)C)c2c(sc1NC(=O)c3cccc(C)c3)CCCCC2 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":18495
  },
  {
    "COADD_ID":"CO-ADD:0311018",
    "INHIB_AVE":8.43,
    "SMILES":"c1(C(=O)Nc(cc2)ccc2Br)c(CC3)c(sc1NC(COc4ccccc4C)=O)CN3C(OCC)=O",
    "HIT":0.0,
    "question":"Can exposure to c1(C(=O)Nc(cc2)ccc2Br)c(CC3)c(sc1NC(COc4ccccc4C)=O)CN3C(OCC)=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":21703
  },
  {
    "COADD_ID":"CO-ADD:0328696",
    "INHIB_AVE":5.23,
    "SMILES":"N(c1cccc(OC)c1)(C2(CCCCC2)C(=O)Nc3c(C)cccc3C)C(=O)c4cc[nH]n4",
    "HIT":0.0,
    "question":"Does N(c1cccc(OC)c1)(C2(CCCCC2)C(=O)Nc3c(C)cccc3C)C(=O)c4cc[nH]n4 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":34635
  },
  {
    "COADD_ID":"CO-ADD:0305006",
    "INHIB_AVE":3.31,
    "SMILES":"[nH]1c2c(nc1SCC(NCCc3ccccc3)=O)cccn2",
    "HIT":0.0,
    "question":"Does the proposed molecule [nH]1c2c(nc1SCC(NCCc3ccccc3)=O)cccn2 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":43210
  },
  {
    "COADD_ID":"CO-ADD:0160213",
    "INHIB_AVE":6.2,
    "SMILES":"[O-][N+](C(C=C1)=CC=C1NC2=NC(N\/N=C\/C(C(O)=C3)=CC=C3O)=NC(N4CCOCC4)=N2)=O",
    "HIT":0.0,
    "question":"Does treatment with [O-][N+](C(C=C1)=CC=C1NC2=NC(N\/N=C\/C(C(O)=C3)=CC=C3O)=NC(N4CCOCC4)=N2)=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":30398
  },
  {
    "COADD_ID":"CO-ADD:0156938",
    "INHIB_AVE":-5.06,
    "SMILES":"O=P1(OCC(C)(C)CO1)C(NC2=CC=C(OC)C=C2)C3=CC(Cl)=CC(Cl)=C3OC",
    "HIT":0.0,
    "question":"Does treatment with O=P1(OCC(C)(C)CO1)C(NC2=CC=C(OC)C=C2)C3=CC(Cl)=CC(Cl)=C3OC result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":71985
  },
  {
    "COADD_ID":"CO-ADD:0301889",
    "INHIB_AVE":38.54,
    "SMILES":"c1(C(O)=O)[nH]nc(C)n1",
    "HIT":0.0,
    "question":"Does c1(C(O)=O)[nH]nc(C)n1 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":571
  },
  {
    "COADD_ID":"CO-ADD:0295131",
    "INHIB_AVE":-2.8,
    "SMILES":"c1(C#N)c(c2ccc(cc2)OC)cc(nc1SCC(=O)Nc3c(cccc3Cl)Cl)c4ccccc4",
    "HIT":0.0,
    "question":"Does treatment with c1(C#N)c(c2ccc(cc2)OC)cc(nc1SCC(=O)Nc3c(cccc3Cl)Cl)c4ccccc4 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":66665
  },
  {
    "COADD_ID":"CO-ADD:0154321",
    "INHIB_AVE":7.0,
    "SMILES":"NC1=C2C(CCCC2)=NC3=C1C(C4=C(C=C(C=C4)OC)OC)C5=C(O3)C=CC6=C5C=CC=C6",
    "HIT":0.0,
    "question":"Can NC1=C2C(CCCC2)=NC3=C1C(C4=C(C=C(C=C4)OC)OC)C5=C(O3)C=CC6=C5C=CC=C6 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":26972
  },
  {
    "COADD_ID":"CO-ADD:0301575",
    "INHIB_AVE":12.32,
    "SMILES":"C1(C(OCCOC)=O)=C(C)NC(=O)CC1c2cccc(Cl)c2",
    "HIT":0.0,
    "question":"Is C1(C(OCCOC)=O)=C(C)NC(=O)CC1c2cccc(Cl)c2 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":11840
  },
  {
    "COADD_ID":"CO-ADD:0221076",
    "INHIB_AVE":-5.01,
    "SMILES":"C(COc1ccc(cc1OC)Br)(=O)N\\N=C\\c(cc2)ccc2C(OC)=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C(COc1ccc(cc1OC)Br)(=O)N\\N=C\\c(cc2)ccc2C(OC)=O?",
    "answer":"No",
    "_id":71898
  },
  {
    "COADD_ID":"CO-ADD:0243743",
    "INHIB_AVE":-3.73,
    "SMILES":"C(C(=C(O)C1=O)OC(=C1)CO)(c2cc(OC)c(OCO3)c3c2OC)CC(OCC)=O",
    "HIT":0.0,
    "question":"Is C(C(=C(O)C1=O)OC(=C1)CO)(c2cc(OC)c(OCO3)c3c2OC)CC(OCC)=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":69117
  },
  {
    "COADD_ID":"CO-ADD:0288056",
    "INHIB_AVE":-6.12,
    "SMILES":"c12c(c3c(cccc3)OC1c4ccccc4)c(c(c5ccc(cc5)OC)n2C6CCCCC6)C",
    "HIT":0.0,
    "question":"Does c12c(c3c(cccc3)OC1c4ccccc4)c(c(c5ccc(cc5)OC)n2C6CCCCC6)C show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":73954
  },
  {
    "COADD_ID":"CO-ADD:0162649",
    "INHIB_AVE":-2.26,
    "SMILES":"c(C#N)(cc(C(C)=O)c(n1)C)c1SCC(OC)=O",
    "HIT":0.0,
    "question":"Does treatment with c(C#N)(cc(C(C)=O)c(n1)C)c1SCC(OC)=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":65143
  },
  {
    "COADD_ID":"CO-ADD:0225981",
    "INHIB_AVE":42.39,
    "SMILES":"n12c(ccc(c3ccccc3)n1)nnc2CCC(=O)NCc4ccccc4OCC",
    "HIT":0.0,
    "question":"Is n12c(ccc(c3ccccc3)n1)nnc2CCC(=O)NCc4ccccc4OCC capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":518
  },
  {
    "COADD_ID":"CO-ADD:0301280",
    "INHIB_AVE":-6.86,
    "SMILES":"c1(SCCC(O)=O)nc(c2n1c3ccccc3)cccc2",
    "HIT":0.0,
    "question":"Is c1(SCCC(O)=O)nc(c2n1c3ccccc3)cccc2 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":75121
  },
  {
    "COADD_ID":"CO-ADD:0254799",
    "INHIB_AVE":-2.69,
    "SMILES":"c1(C)c(C)ccc(Oc(cc2)ccc2Oc(cc3)ccc3Oc(ccc(c4C)C)c4)c1",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(C)c(C)ccc(Oc(cc2)ccc2Oc(cc3)ccc3Oc(ccc(c4C)C)c4)c1?",
    "answer":"No",
    "_id":66364
  },
  {
    "COADD_ID":"CO-ADD:0154974",
    "INHIB_AVE":-12.6,
    "SMILES":"N#CC1(C#N)[C@]2([H])N([C@H](C(C3(C[C@H]4C5)C[C@H]5C[C@H](C4)C3)=O)[C@H]1C(C=CC=C6)=C6F)C7=CC=CC=C7C=C2",
    "HIT":0.0,
    "question":"Can N#CC1(C#N)[C@]2([H])N([C@H](C(C3(C[C@H]4C5)C[C@H]5C[C@H](C4)C3)=O)[C@H]1C(C=CC=C6)=C6F)C7=CC=CC=C7C=C2 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":80351
  },
  {
    "COADD_ID":"CO-ADD:0321040",
    "INHIB_AVE":5.36,
    "SMILES":"n1c(C#N)c(Cl)cc(Cl)c1Sc(cc2C(C)(C)C)cc(c2O)C(C)(C)C",
    "HIT":0.0,
    "question":"Can exposure to n1c(C#N)c(Cl)cc(Cl)c1Sc(cc2C(C)(C)C)cc(c2O)C(C)(C)C lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":34040
  },
  {
    "COADD_ID":"CO-ADD:0319249",
    "INHIB_AVE":9.31,
    "SMILES":"S(=O)(=O)(c1ccc(cc1)NC(C)=O)\\N=C(\/NC2)\\NCN2C3CCCCC3",
    "HIT":0.0,
    "question":"Is S(=O)(=O)(c1ccc(cc1)NC(C)=O)\\N=C(\/NC2)\\NCN2C3CCCCC3 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":19004
  },
  {
    "COADD_ID":"CO-ADD:0245589",
    "INHIB_AVE":-3.76,
    "SMILES":"c1(SCC(=O)N\\N=C(\/C)\\c2ccccc2O)sc(c3n1)cccc3",
    "HIT":0.0,
    "question":"Does c1(SCC(=O)N\\N=C(\/C)\\c2ccccc2O)sc(c3n1)cccc3 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":69184
  },
  {
    "COADD_ID":"CO-ADD:0216960",
    "INHIB_AVE":2.51,
    "SMILES":"C(=O)(N\\N=C(\/C)\\CC(=O)Nc1cc(C)ccc1OC)c2cccc(cccc3)c23",
    "HIT":0.0,
    "question":"Can exposure to C(=O)(N\\N=C(\/C)\\CC(=O)Nc1cc(C)ccc1OC)c2cccc(cccc3)c23 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":46852
  },
  {
    "COADD_ID":"CO-ADD:0253771",
    "INHIB_AVE":-2.54,
    "SMILES":"N(CN(CC1)CCO1)(c(cccc2)c2C3(O)CC(c4ccccc4)=O)C3=O",
    "HIT":0.0,
    "question":"Is N(CN(CC1)CCO1)(c(cccc2)c2C3(O)CC(c4ccccc4)=O)C3=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":65935
  },
  {
    "COADD_ID":"CO-ADD:0157178",
    "INHIB_AVE":14.58,
    "SMILES":"[O-][N+](C1=CC=CC=C1COC2=C(C=CC=C2)\/C=N\/NC(C3=CC=CC(NC(CC4=CC=CC=C4)=O)=C3)=O)=O",
    "HIT":0.0,
    "question":"Does [O-][N+](C1=CC=CC=C1COC2=C(C=CC=C2)\/C=N\/NC(C3=CC=CC(NC(CC4=CC=CC=C4)=O)=C3)=O)=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":8148
  },
  {
    "COADD_ID":"CO-ADD:0284631",
    "INHIB_AVE":0.75,
    "SMILES":"c1(ccn(C(c2ccccc2)=O)n1)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Does c1(ccn(C(c2ccccc2)=O)n1)[N+](=O)[O-] demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":54510
  },
  {
    "COADD_ID":"CO-ADD:0284102",
    "INHIB_AVE":7.63,
    "SMILES":"c(C(OCC)=O)(c(cc(O)cc1)c1n2Cc3ccccc3)c2C",
    "HIT":0.0,
    "question":"Can c(C(OCC)=O)(c(cc(O)cc1)c1n2Cc3ccccc3)c2C act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":24563
  },
  {
    "COADD_ID":"CO-ADD:0256237",
    "INHIB_AVE":3.91,
    "SMILES":"C1(c2ccccc2)(N3)C(c4ccccc4)(N=C(S\\C(=C\\c(cc5)ccc5[N+](=O)[O-])\\C6=O)N36)N(C(=O)N1C)C",
    "HIT":0.0,
    "question":"Is C1(c2ccccc2)(N3)C(c4ccccc4)(N=C(S\\C(=C\\c(cc5)ccc5[N+](=O)[O-])\\C6=O)N36)N(C(=O)N1C)C capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":40570
  },
  {
    "COADD_ID":"CO-ADD:0234888",
    "INHIB_AVE":-1.92,
    "SMILES":"c1(c2ccccc2C)oc(c3n1)ccc(c3)NC(=O)c4ccc(cc4)Cl",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(c2ccccc2C)oc(c3n1)ccc(c3)NC(=O)c4ccc(cc4)Cl?",
    "answer":"No",
    "_id":64118
  },
  {
    "COADD_ID":"CO-ADD:0283673",
    "INHIB_AVE":-6.06,
    "SMILES":"[N+](=O)([O-])c(cc1)ccc1C(=O)Nc2c(Br)cc(cc2Br)O",
    "HIT":0.0,
    "question":"Can [N+](=O)([O-])c(cc1)ccc1C(=O)Nc2c(Br)cc(cc2Br)O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":73850
  },
  {
    "COADD_ID":"CO-ADD:0307596",
    "INHIB_AVE":6.85,
    "SMILES":"C(C(OCC)=O)(NC(CCl)=O)(C(F)(F)F)Nc1sc(c2c1C(N)=O)CCCC2",
    "HIT":0.0,
    "question":"Does treatment with C(C(OCC)=O)(NC(CCl)=O)(C(F)(F)F)Nc1sc(c2c1C(N)=O)CCCC2 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":27631
  },
  {
    "COADD_ID":"CO-ADD:0163327",
    "INHIB_AVE":2.27,
    "SMILES":"n1c(c2ccc(cc2)Cl)csc1N\\N=C(\\Cc3ccccc3[N+](=O)[O-])\/C(O)=O.Br",
    "HIT":0.0,
    "question":"Can exposure to n1c(c2ccc(cc2)Cl)csc1N\\N=C(\\Cc3ccccc3[N+](=O)[O-])\/C(O)=O.Br lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":47920
  },
  {
    "COADD_ID":"CO-ADD:0234796",
    "INHIB_AVE":3.77,
    "SMILES":"C(CN(CC1)CCO1)(CNC(c2ccccc2)=O)([N+](=O)[O-])[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C(CN(CC1)CCO1)(CNC(c2ccccc2)=O)([N+](=O)[O-])[N+](=O)[O-]?",
    "answer":"No",
    "_id":41199
  },
  {
    "COADD_ID":"CO-ADD:0157299",
    "INHIB_AVE":14.58,
    "SMILES":"O=C(COC1=CC=C(CCCCC)C=C1)N\/N=C\/C(C=C2)=C(OC(C)=O)C=C2OC(C)=O",
    "HIT":0.0,
    "question":"Is O=C(COC1=CC=C(CCCCC)C=C1)N\/N=C\/C(C=C2)=C(OC(C)=O)C=C2OC(C)=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":8151
  },
  {
    "COADD_ID":"CO-ADD:0252484",
    "INHIB_AVE":-2.67,
    "SMILES":"N1(c2ccc(c(I)c2)C)C(=O)c(c3C1=O)cccc3",
    "HIT":0.0,
    "question":"Does N1(c2ccc(c(I)c2)C)C(=O)c(c3C1=O)cccc3 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":66298
  },
  {
    "COADD_ID":"CO-ADD:0222031",
    "INHIB_AVE":13.65,
    "SMILES":"C1(c(cc(cc2C3=N\\C(\\C(=O)O3)=C\\c(cc4)ccc4OCCCC)C5=N\\C(\\C(=O)O5)=C\/c(cc6)ccc6OCCCC)c2)=N\\C(\\C(=O)O1)=C\\c(cc7)ccc7OCCCC",
    "HIT":0.0,
    "question":"Does C1(c(cc(cc2C3=N\\C(\\C(=O)O3)=C\\c(cc4)ccc4OCCCC)C5=N\\C(\\C(=O)O5)=C\/c(cc6)ccc6OCCCC)c2)=N\\C(\\C(=O)O1)=C\\c(cc7)ccc7OCCCC show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":9537
  },
  {
    "COADD_ID":"CO-ADD:0255301",
    "INHIB_AVE":-2.52,
    "SMILES":"C(\/CC1)(=C\/c(cc2OC)cc(c2OC)OC)\\C(=O)\\C(\\C1)=C\\c(cc3OC)cc(c3OC)OC",
    "HIT":0.0,
    "question":"Does treatment with C(\/CC1)(=C\/c(cc2OC)cc(c2OC)OC)\\C(=O)\\C(\\C1)=C\\c(cc3OC)cc(c3OC)OC result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":65881
  },
  {
    "COADD_ID":"CO-ADD:0226839",
    "INHIB_AVE":2.95,
    "SMILES":"C1(=N2)N(c3c(cccc3)N=C1Oc4ccccc4C)C(N2CC(=O)Nc5ccccc5C(F)(F)F)=O",
    "HIT":0.0,
    "question":"Is C1(=N2)N(c3c(cccc3)N=C1Oc4ccccc4C)C(N2CC(=O)Nc5ccccc5C(F)(F)F)=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":44868
  },
  {
    "COADD_ID":"CO-ADD:0136391",
    "INHIB_AVE":-12.36,
    "SMILES":"n1c(cccc2)c2c(NC(OCC)=O)c3c1cccc3",
    "HIT":0.0,
    "question":"Is n1c(cccc2)c2c(NC(OCC)=O)c3c1cccc3 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":80234
  },
  {
    "COADD_ID":"CO-ADD:0320050",
    "INHIB_AVE":3.17,
    "SMILES":"N(CC1N2CCc(cccc3)c13)(C2c4ccc(c(OCC)c4)OC)S(=O)(=O)c5ccc(c6c5cccn6)OC",
    "HIT":0.0,
    "question":"Is N(CC1N2CCc(cccc3)c13)(C2c4ccc(c(OCC)c4)OC)S(=O)(=O)c5ccc(c6c5cccn6)OC capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":43872
  },
  {
    "COADD_ID":"CO-ADD:0286532",
    "INHIB_AVE":-3.05,
    "SMILES":"c1(c(N)ncnc1N2CCCC2)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(c(N)ncnc1N2CCCC2)[N+](=O)[O-]?",
    "answer":"No",
    "_id":67354
  },
  {
    "COADD_ID":"CO-ADD:0278069",
    "INHIB_AVE":19.72,
    "SMILES":"C(\/S\\C(\\N1CC)=N\/c(ccc2c3cccn2)c3)(\\C1=O)=C(\/Sc(c45)ccc(Cl)c4)\\N5C",
    "HIT":0.0,
    "question":"Does treatment with C(\/S\\C(\\N1CC)=N\/c(ccc2c3cccn2)c3)(\\C1=O)=C(\/Sc(c45)ccc(Cl)c4)\\N5C result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":3036
  },
  {
    "COADD_ID":"CO-ADD:0294565",
    "INHIB_AVE":-19.61,
    "SMILES":"N1(C(c2ccc(cc2)Br)CC(c3ccc(cc3)Br)=N1)C(=O)c4ccccc4Cl",
    "HIT":0.0,
    "question":"Can N1(C(c2ccc(cc2)Br)CC(c3ccc(cc3)Br)=N1)C(=O)c4ccccc4Cl effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":82114
  },
  {
    "COADD_ID":"CO-ADD:0149867",
    "INHIB_AVE":4.95,
    "SMILES":"ClC(OC1=C2C=CC3=C1C=CC=C3)=C(C2C4=C(C=CC=C4)[N+]([O-])=O)C#N",
    "HIT":0.0,
    "question":"Does treatment with ClC(OC1=C2C=CC3=C1C=CC=C3)=C(C2C4=C(C=CC=C4)[N+]([O-])=O)C#N result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":35852
  },
  {
    "COADD_ID":"CO-ADD:0278262",
    "INHIB_AVE":0.82,
    "SMILES":"c1(Sc2ccc(\\C=N\\NC(=O)c3ccco3)o2)nnc(c4ccccc4)n1c5ccccc5",
    "HIT":0.0,
    "question":"Can c1(Sc2ccc(\\C=N\\NC(=O)c3ccco3)o2)nnc(c4ccccc4)n1c5ccccc5 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":54238
  },
  {
    "COADD_ID":"CO-ADD:0304466",
    "INHIB_AVE":-6.62,
    "SMILES":"c1(C(NCCCN(CC)CC)=O)nnn(Cc2ccccc2)c1N",
    "HIT":0.0,
    "question":"Is c1(C(NCCCN(CC)CC)=O)nnn(Cc2ccccc2)c1N effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":74769
  },
  {
    "COADD_ID":"CO-ADD:0329586",
    "INHIB_AVE":-1.73,
    "SMILES":"S(=O)(=O)(c1ccc(cc1)OCC)Nc(cc2)ccc2OCC(O)=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound S(=O)(=O)(c1ccc(cc1)OCC)Nc(cc2)ccc2OCC(O)=O?",
    "answer":"No",
    "_id":63529
  },
  {
    "COADD_ID":"CO-ADD:0136025",
    "INHIB_AVE":8.94,
    "SMILES":"O=C1N(C(=S)N([H])C(=O)C1(CC)CC=CC)[H]",
    "HIT":0.0,
    "question":"Can exposure to O=C1N(C(=S)N([H])C(=O)C1(CC)CC=CC)[H] lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":20085
  },
  {
    "COADD_ID":"CO-ADD:0156486",
    "INHIB_AVE":-5.33,
    "SMILES":"O=S(C1=CC(C(OC2=CC(NC(C3=CC=CO3)=O)=CC=C2)=O)=C(Cl)C=C1Cl)(N4CCOCC4)=O",
    "HIT":0.0,
    "question":"Can exposure to O=S(C1=CC(C(OC2=CC(NC(C3=CC=CO3)=O)=CC=C2)=O)=C(Cl)C=C1Cl)(N4CCOCC4)=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":72526
  },
  {
    "COADD_ID":"CO-ADD:0285830",
    "INHIB_AVE":2.46,
    "SMILES":"S(=O)(=O)(N(CCCC1C(=O)N(CC)CC)C1)c2cc(ccc2N3CCCCCC3)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Does S(=O)(=O)(N(CCCC1C(=O)N(CC)CC)C1)c2cc(ccc2N3CCCCCC3)[N+](=O)[O-] demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":47054
  },
  {
    "COADD_ID":"CO-ADD:0157950",
    "INHIB_AVE":6.25,
    "SMILES":"O=C(N\/N=C(CCC)\\C1=CC=CC=C1)C2=CC=CC=C2Br",
    "HIT":0.0,
    "question":"Can O=C(N\/N=C(CCC)\\C1=CC=CC=C1)C2=CC=CC=C2Br effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":30219
  },
  {
    "COADD_ID":"CO-ADD:0304278",
    "INHIB_AVE":-6.79,
    "SMILES":"N1(N=CC(=C(Cl)C1=O)Cl)C23CC4CC(CC(C4)C2)C3",
    "HIT":0.0,
    "question":"Does treatment with N1(N=CC(=C(Cl)C1=O)Cl)C23CC4CC(CC(C4)C2)C3 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":75012
  },
  {
    "COADD_ID":"CO-ADD:0227348",
    "INHIB_AVE":15.22,
    "SMILES":"c1(\\C=N\/NC(CNc(ccc(c23)cccc2)c3)=O)c(O)ccc(cccc4)c14",
    "HIT":0.0,
    "question":"Does the proposed molecule c1(\\C=N\/NC(CNc(ccc(c23)cccc2)c3)=O)c(O)ccc(cccc4)c14 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":7299
  },
  {
    "COADD_ID":"CO-ADD:0255425",
    "INHIB_AVE":-9.72,
    "SMILES":"[N+](=O)([O-])c1ccc(cc1C)C(=O)Oc(ccc(c23)cccc2)c3",
    "HIT":0.0,
    "question":"Does [N+](=O)([O-])c1ccc(cc1C)C(=O)Oc(ccc(c23)cccc2)c3 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":78491
  },
  {
    "COADD_ID":"CO-ADD:0254704",
    "INHIB_AVE":-2.65,
    "SMILES":"N(\/c1ccccc1C)=C\\c(ccc(c2)N(CC)CC)c2O",
    "HIT":0.0,
    "question":"Is N(\/c1ccccc1C)=C\\c(ccc(c2)N(CC)CC)c2O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":66240
  },
  {
    "COADD_ID":"CO-ADD:0254765",
    "INHIB_AVE":17.93,
    "SMILES":"C(C(c1ccccc1)=O)(C2c(cc3)ccc3N(C)C)=C(O)C(N2c4cccc(C)c4)=O",
    "HIT":0.0,
    "question":"Does treatment with C(C(c1ccccc1)=O)(C2c(cc3)ccc3N(C)C)=C(O)C(N2c4cccc(C)c4)=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":4358
  },
  {
    "COADD_ID":"CO-ADD:0235239",
    "INHIB_AVE":10.7,
    "SMILES":"c1(ccccc1O)C(=O)N\\N=C\\c(cc2)cc(c2OC(C)=O)OC",
    "HIT":0.0,
    "question":"Does treatment with c1(ccccc1O)C(=O)N\\N=C\\c(cc2)cc(c2OC(C)=O)OC result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":15214
  },
  {
    "COADD_ID":"CO-ADD:0324522",
    "INHIB_AVE":2.03,
    "SMILES":"S(=O)(=O)(NC1CCCCC1)C2=C(C)NC(NC2=O)=O",
    "HIT":0.0,
    "question":"Does treatment with S(=O)(=O)(NC1CCCCC1)C2=C(C)NC(NC2=O)=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":48944
  },
  {
    "COADD_ID":"CO-ADD:0284718",
    "INHIB_AVE":-3.86,
    "SMILES":"N1(C(c2ccc(cc2)Br)CC(c3ccc(cc3)C)=N1)C(=N)SC(CC(N4c5ccc(cc5)I)=O)C4=O",
    "HIT":0.0,
    "question":"Is N1(C(c2ccc(cc2)Br)CC(c3ccc(cc3)C)=N1)C(=N)SC(CC(N4c5ccc(cc5)I)=O)C4=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":69422
  },
  {
    "COADD_ID":"CO-ADD:0229125",
    "INHIB_AVE":-3.58,
    "SMILES":"C(=O)(c1ccc(cc1)C)Nc(cccc2C(=O)N\\N=C\\c3cccc(CC=C)c3O)c2",
    "HIT":0.0,
    "question":"Is C(=O)(c1ccc(cc1)C)Nc(cccc2C(=O)N\\N=C\\c3cccc(CC=C)c3O)c2 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":68748
  },
  {
    "COADD_ID":"CO-ADD:0256461",
    "INHIB_AVE":0.96,
    "SMILES":"C1(NC(CSc2sc3c(ccc(c3)\\N=C\\c4c(cccc4Cl)Cl)n2)=O)=C(C)N(N(c5ccccc5)C1=O)C",
    "HIT":0.0,
    "question":"Is C1(NC(CSc2sc3c(ccc(c3)\\N=C\\c4c(cccc4Cl)Cl)n2)=O)=C(C)N(N(c5ccccc5)C1=O)C capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":53626
  },
  {
    "COADD_ID":"CO-ADD:0234395",
    "INHIB_AVE":3.06,
    "SMILES":"N(\/c1ccccc1I)=C\\c2ccccc2Cl",
    "HIT":0.0,
    "question":"Does the proposed molecule N(\/c1ccccc1I)=C\\c2ccccc2Cl exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":44361
  },
  {
    "COADD_ID":"CO-ADD:0323441",
    "INHIB_AVE":12.35,
    "SMILES":"c1(NCn2c(C)cc(C)n2)nonc1OCCn3c(C)cc(C)n3",
    "HIT":0.0,
    "question":"Does treatment with c1(NCn2c(C)cc(C)n2)nonc1OCCn3c(C)cc(C)n3 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":11764
  },
  {
    "COADD_ID":"CO-ADD:0234674",
    "INHIB_AVE":1.7,
    "SMILES":"c1(c(Br)cc(cc1\\C=N\\NC(CNC(=O)c2ccc(cc2)Cl)=O)Br)OC(=O)c3cccc(F)c3",
    "HIT":0.0,
    "question":"Can c1(c(Br)cc(cc1\\C=N\\NC(CNC(=O)c2ccc(cc2)Cl)=O)Br)OC(=O)c3cccc(F)c3 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":50439
  },
  {
    "COADD_ID":"CO-ADD:0331925",
    "INHIB_AVE":2.14,
    "SMILES":"C1(=Cc2c(OC1=O)cccc2)C(=O)N3CCC(CC3)C(N)=O",
    "HIT":0.0,
    "question":"Can C1(=Cc2c(OC1=O)cccc2)C(=O)N3CCC(CC3)C(N)=O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":48466
  },
  {
    "COADD_ID":"CO-ADD:0318983",
    "INHIB_AVE":4.35,
    "SMILES":"N1(c2ccc(cc2)OCC(O)COc3cccc(cccc4)c34)C(=O)c(c5C1=O)cccc5",
    "HIT":0.0,
    "question":"Is N1(c2ccc(cc2)OCC(O)COc3cccc(cccc4)c34)C(=O)c(c5C1=O)cccc5 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":38609
  },
  {
    "COADD_ID":"CO-ADD:0303519",
    "INHIB_AVE":41.19,
    "SMILES":"C12=C(CC(c3ccc(c(OC)c3)OC)CC1=O)Nc(c4NC2c5ccc(cc5)NC(C)=O)cccc4",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C12=C(CC(c3ccc(c(OC)c3)OC)CC1=O)Nc(c4NC2c5ccc(cc5)NC(C)=O)cccc4?",
    "answer":"No",
    "_id":535
  },
  {
    "COADD_ID":"CO-ADD:0160450",
    "INHIB_AVE":-13.85,
    "SMILES":"O=C(N\/N=C\/C1=CC(I)=CC(I)=C1O)C2C(C3=CC=CC=C3)(C4=CC=CC=C4)C2",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound O=C(N\/N=C\/C1=CC(I)=CC(I)=C1O)C2C(C3=CC=CC=C3)(C4=CC=CC=C4)C2?",
    "answer":"No",
    "_id":80910
  },
  {
    "COADD_ID":"CO-ADD:0249151",
    "INHIB_AVE":-25.63,
    "SMILES":"C(\/C1)(=C\/c(cc2)ccc2[N+](=O)[O-])\\C(=O)\\C(\\CN1CCC)=C\\c(cc3)ccc3[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Is C(\/C1)(=C\/c(cc2)ccc2[N+](=O)[O-])\\C(=O)\\C(\\CN1CCC)=C\\c(cc3)ccc3[N+](=O)[O-] effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":82480
  },
  {
    "COADD_ID":"CO-ADD:0158060",
    "INHIB_AVE":6.2,
    "SMILES":"[O-][N+](C(C=CC=C1)=C1NC(\/C=C\/C2=CC=CC(Br)=C2)=O)=O",
    "HIT":0.0,
    "question":"Does the proposed molecule [O-][N+](C(C=CC=C1)=C1NC(\/C=C\/C2=CC=CC(Br)=C2)=O)=O exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":30417
  },
  {
    "COADD_ID":"CO-ADD:0254547",
    "INHIB_AVE":-15.32,
    "SMILES":"C1(c2ccc(cc2)SC)N(c3ccccc3)CCN1c4ccccc4",
    "HIT":0.0,
    "question":"Can C1(c2ccc(cc2)SC)N(c3ccccc3)CCN1c4ccccc4 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":81391
  },
  {
    "COADD_ID":"CO-ADD:0257742",
    "INHIB_AVE":-9.62,
    "SMILES":"c(cc(Br)cc1Br)(c12)\\C(=N\\c(cc3)ccc3C)\\C(N2)=O",
    "HIT":0.0,
    "question":"Can c(cc(Br)cc1Br)(c12)\\C(=N\\c(cc3)ccc3C)\\C(N2)=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":78414
  },
  {
    "COADD_ID":"CO-ADD:0235976",
    "INHIB_AVE":-3.69,
    "SMILES":"N(CC(=O)N\\N=C\\c(ccc(c1[N+](=O)[O-])Sc2sc(c3n2)cccc3)c1)(c(cccc4)c45)c(cccc6)c6C5=O",
    "HIT":0.0,
    "question":"Does the proposed molecule N(CC(=O)N\\N=C\\c(ccc(c1[N+](=O)[O-])Sc2sc(c3n2)cccc3)c1)(c(cccc4)c45)c(cccc6)c6C5=O exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":69018
  },
  {
    "COADD_ID":"CO-ADD:0292384",
    "INHIB_AVE":5.66,
    "SMILES":"c1(c(N)nc(c23)CCC(C(C)(C)C)C2)c3c4c(OC1=O)cccc4",
    "HIT":0.0,
    "question":"Can c1(c(N)nc(c23)CCC(C(C)(C)C)C2)c3c4c(OC1=O)cccc4 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":32692
  },
  {
    "COADD_ID":"CO-ADD:0221568",
    "INHIB_AVE":11.55,
    "SMILES":"C1(C(=O)Nc(cc2)ccc2OC)CC13CCC3",
    "HIT":0.0,
    "question":"Does C1(C(=O)Nc(cc2)ccc2OC)CC13CCC3 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":13346
  },
  {
    "COADD_ID":"CO-ADD:0302624",
    "INHIB_AVE":-3.3,
    "SMILES":"N1(c2ccc(cc2)OC)C(\\C=C\\c(cccn3)c3)=Nc(c4C1=O)cccc4",
    "HIT":0.0,
    "question":"Does the proposed molecule N1(c2ccc(cc2)OC)C(\\C=C\\c(cccn3)c3)=Nc(c4C1=O)cccc4 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":68006
  },
  {
    "COADD_ID":"CO-ADD:0329008",
    "INHIB_AVE":0.84,
    "SMILES":"C1(C2=O)C(C(NC1(CCSC)C(O)=O)c3cccc(OC)c3O)C(N2c4ccc(cc4)OC)=O",
    "HIT":0.0,
    "question":"Can exposure to C1(C2=O)C(C(NC1(CCSC)C(O)=O)c3cccc(OC)c3O)C(N2c4ccc(cc4)OC)=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":54149
  },
  {
    "COADD_ID":"CO-ADD:0241619",
    "INHIB_AVE":1.52,
    "SMILES":"N1(c2cccc(c2)c3csc(Nc4cc(Cl)cc(Cl)c4)n3)C(=O)c5c(cccc5)C1=O.Br",
    "HIT":0.0,
    "question":"Does treatment with N1(c2cccc(c2)c3csc(Nc4cc(Cl)cc(Cl)c4)n3)C(=O)c5c(cccc5)C1=O.Br result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":51205
  },
  {
    "COADD_ID":"CO-ADD:0256399",
    "INHIB_AVE":1.07,
    "SMILES":"N1(c(cccc2c3oc(c4n3)cccc4)c2)C(=O)c5c(c(cccc6)c6C1=O)cccc5",
    "HIT":0.0,
    "question":"Can N1(c(cccc2c3oc(c4n3)cccc4)c2)C(=O)c5c(c(cccc6)c6C1=O)cccc5 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":53164
  },
  {
    "COADD_ID":"CO-ADD:0299652",
    "INHIB_AVE":13.95,
    "SMILES":"C(=O)(CN1CCC(CC1)C)Nc(ccc(c23)cccc2)c3",
    "HIT":0.0,
    "question":"Is C(=O)(CN1CCC(CC1)C)Nc(ccc(c23)cccc2)c3 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":9104
  },
  {
    "COADD_ID":"CO-ADD:0222482",
    "INHIB_AVE":7.59,
    "SMILES":"N1\\C(=N\\N=C\\c(cc2)ccc2Cl)\\S\\C(=C\/c(cc(Br)c(c3Br)O)c3O)\\C1=O",
    "HIT":0.0,
    "question":"Is N1\\C(=N\\N=C\\c(cc2)ccc2Cl)\\S\\C(=C\/c(cc(Br)c(c3Br)O)c3O)\\C1=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":24707
  },
  {
    "COADD_ID":"CO-ADD:0215043",
    "INHIB_AVE":9.37,
    "SMILES":"c1(SCC(=O)N\\N=C\\c(cc2)ccn2)[nH]c(c3n1)cccc3",
    "HIT":0.0,
    "question":"Does the proposed molecule c1(SCC(=O)N\\N=C\\c(cc2)ccn2)[nH]c(c3n1)cccc3 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":18822
  },
  {
    "COADD_ID":"CO-ADD:0218065",
    "INHIB_AVE":7.44,
    "SMILES":"N1(CNc(cc2)ccc2Br)C(=O)\\C(\\NC1=S)=C\/c3cccc(Br)c3",
    "HIT":0.0,
    "question":"Does N1(CNc(cc2)ccc2Br)C(=O)\\C(\\NC1=S)=C\/c3cccc(Br)c3 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":25307
  },
  {
    "COADD_ID":"CO-ADD:0294007",
    "INHIB_AVE":-6.17,
    "SMILES":"c1(c(C)nn(c2ccccc2)c1O)C(c3ccccc3OCc(cc4)ccc4F)c5c(C)nn(c6ccccc6)c5O",
    "HIT":0.0,
    "question":"Can c1(c(C)nn(c2ccccc2)c1O)C(c3ccccc3OCc(cc4)ccc4F)c5c(C)nn(c6ccccc6)c5O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":74042
  },
  {
    "COADD_ID":"CO-ADD:0215744",
    "INHIB_AVE":-2.6,
    "SMILES":"N1(c2ccccc2)CC(CC1=O)C(=O)N\\N=C\\c(cc3)ccc3OC",
    "HIT":0.0,
    "question":"Is N1(c2ccccc2)CC(CC1=O)C(=O)N\\N=C\\c(cc3)ccc3OC capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":66091
  },
  {
    "COADD_ID":"CO-ADD:0241719",
    "INHIB_AVE":3.98,
    "SMILES":"C1(C#N)(C#N)[C@H](c2ccccc2Cl)[C@H](N(c3c(cccc3)C=C4)[C@@]14[H])C(=O)C(C)(C)C",
    "HIT":0.0,
    "question":"Does C1(C#N)(C#N)[C@H](c2ccccc2Cl)[C@H](N(c3c(cccc3)C=C4)[C@@]14[H])C(=O)C(C)(C)C demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":40264
  },
  {
    "COADD_ID":"CO-ADD:0135704",
    "INHIB_AVE":-0.45,
    "SMILES":"[H]N1CCC(Cc(cccc2)c2)(O)CC1",
    "HIT":0.0,
    "question":"Does the proposed molecule [H]N1CCC(Cc(cccc2)c2)(O)CC1 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":59200
  },
  {
    "COADD_ID":"CO-ADD:0258913",
    "INHIB_AVE":-1.46,
    "SMILES":"n1(C)c(c2ccccc2)cnc1S",
    "HIT":0.0,
    "question":"Does treatment with n1(C)c(c2ccccc2)cnc1S result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":62619
  },
  {
    "COADD_ID":"CO-ADD:0220760",
    "INHIB_AVE":3.06,
    "SMILES":"c(Nc(ccc(c1C)C)c1)(nc(N\\N=C\/c2c(O)ccc(cccc3)c23)nc4Nc(cc5)ccc5[N+](=O)[O-])n4",
    "HIT":0.0,
    "question":"Does treatment with c(Nc(ccc(c1C)C)c1)(nc(N\\N=C\/c2c(O)ccc(cccc3)c23)nc4Nc(cc5)ccc5[N+](=O)[O-])n4 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":44376
  },
  {
    "COADD_ID":"CO-ADD:0255107",
    "INHIB_AVE":17.94,
    "SMILES":"C1(CC1)(C(C=C2)C(C3C(=O)Nc(cc4)ccc4C(OC)=O)C(O)=O)C23",
    "HIT":0.0,
    "question":"Can exposure to C1(CC1)(C(C=C2)C(C3C(=O)Nc(cc4)ccc4C(OC)=O)C(O)=O)C23 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":4339
  },
  {
    "COADD_ID":"CO-ADD:0227978",
    "INHIB_AVE":0.44,
    "SMILES":"[N+](=O)([O-])c(ccc(c1\\C=N\\NC(COc2ccc(cc2OC)Br)=O)OC)c1",
    "HIT":0.0,
    "question":"Does [N+](=O)([O-])c(ccc(c1\\C=N\\NC(COc2ccc(cc2OC)Br)=O)OC)c1 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":55702
  },
  {
    "COADD_ID":"CO-ADD:0299615",
    "INHIB_AVE":13.96,
    "SMILES":"N1(c2ccc(cc2)OC(F)(F)F)C(=O)c3c(c(cccc4)c4C1=O)cccc3",
    "HIT":0.0,
    "question":"Does N1(c2ccc(cc2)OC(F)(F)F)C(=O)c3c(c(cccc4)c4C1=O)cccc3 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":9086
  },
  {
    "COADD_ID":"CO-ADD:0227556",
    "INHIB_AVE":-2.08,
    "SMILES":"c1(c(Br)cc(cc1\\C=N\\NC(COc(cc2)ccc2C)=O)Br)OC(c3ccccc3)=O",
    "HIT":0.0,
    "question":"Does the proposed molecule c1(c(Br)cc(cc1\\C=N\\NC(COc(cc2)ccc2C)=O)Br)OC(c3ccccc3)=O exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":64593
  },
  {
    "COADD_ID":"CO-ADD:0215168",
    "INHIB_AVE":8.83,
    "SMILES":"N1(c2ccc(cc2)OC)C(=O)C3C(C(\\C(=C(\/c4ccccc4)\\c5ccccc5)\\C36)C=C6C(C)(C)C)C1=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound N1(c2ccc(cc2)OC)C(=O)C3C(C(\\C(=C(\/c4ccccc4)\\c5ccccc5)\\C36)C=C6C(C)(C)C)C1=O?",
    "answer":"No",
    "_id":20459
  },
  {
    "COADD_ID":"CO-ADD:0250535",
    "INHIB_AVE":-9.26,
    "SMILES":"c1(SCC)nc(c2n1CC(=O)Nc3ccccc3[N+](=O)[O-])cccc2",
    "HIT":0.0,
    "question":"Is c1(SCC)nc(c2n1CC(=O)Nc3ccccc3[N+](=O)[O-])cccc2 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":78123
  },
  {
    "COADD_ID":"CO-ADD:0254469",
    "INHIB_AVE":2.61,
    "SMILES":"C12(c(cccc3)c3C(c4ccccc4)(c5ccccc5)O1)N(c6ccccc6)N=C(C(OCC)=O)S2",
    "HIT":0.0,
    "question":"Does the proposed molecule C12(c(cccc3)c3C(c4ccccc4)(c5ccccc5)O1)N(c6ccccc6)N=C(C(OCC)=O)S2 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":46382
  },
  {
    "COADD_ID":"CO-ADD:0253523",
    "INHIB_AVE":-2.49,
    "SMILES":"c1(SCC(=O)N\\N=C(\/C)\\c2ccc(cc2)C)ncccn1",
    "HIT":0.0,
    "question":"Can c1(SCC(=O)N\\N=C(\/C)\\c2ccc(cc2)C)ncccn1 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":65792
  },
  {
    "COADD_ID":"CO-ADD:0136909",
    "INHIB_AVE":6.46,
    "SMILES":"Clc(ccc(OCC(CN1CCN(CC1)c(cc(cc2)Cl)c2)O)c3)c3",
    "HIT":0.0,
    "question":"Can exposure to Clc(ccc(OCC(CN1CCN(CC1)c(cc(cc2)Cl)c2)O)c3)c3 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":29275
  },
  {
    "COADD_ID":"CO-ADD:0230195",
    "INHIB_AVE":-0.81,
    "SMILES":"C(=O)(N\\N=C\\c1ccc(cc1OC)OC)c2ccc(cc2)OCCCCCCCCCC",
    "HIT":0.0,
    "question":"Can C(=O)(N\\N=C\\c1ccc(cc1OC)OC)c2ccc(cc2)OCCCCCCCCCC effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":60456
  },
  {
    "COADD_ID":"CO-ADD:0326751",
    "INHIB_AVE":-1.06,
    "SMILES":"n12c(ncc(C#N)c1c3cccc(C)c3)cc(c4ccc(cc4)C)n2",
    "HIT":0.0,
    "question":"Does n12c(ncc(C#N)c1c3cccc(C)c3)cc(c4ccc(cc4)C)n2 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":61293
  },
  {
    "COADD_ID":"CO-ADD:0254342",
    "INHIB_AVE":17.96,
    "SMILES":"c1(Nc(cc2)ccc2C)c(CC=C)c(C)nc(c3ccccc3)n1",
    "HIT":0.0,
    "question":"Does c1(Nc(cc2)ccc2C)c(CC=C)c(C)nc(c3ccccc3)n1 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":4322
  },
  {
    "COADD_ID":"CO-ADD:0319254",
    "INHIB_AVE":9.31,
    "SMILES":"c1(C2c(cccn3)c3)c([nH]nc1c4cccs4)OC(N)=C2C#N",
    "HIT":0.0,
    "question":"Is c1(C2c(cccn3)c3)c([nH]nc1c4cccs4)OC(N)=C2C#N capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":19001
  },
  {
    "COADD_ID":"CO-ADD:0291761",
    "INHIB_AVE":4.61,
    "SMILES":"c1(cc(n2)c3cccc(Br)c3)n2c(cc(C)n1)C",
    "HIT":0.0,
    "question":"Can c1(cc(n2)c3cccc(Br)c3)n2c(cc(C)n1)C effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":37429
  },
  {
    "COADD_ID":"CO-ADD:0302080",
    "INHIB_AVE":8.43,
    "SMILES":"c1(C(O)=O)cc(OC)c(cc1NC(C2CCCCC2)=O)OC",
    "HIT":0.0,
    "question":"Can exposure to c1(C(O)=O)cc(OC)c(cc1NC(C2CCCCC2)=O)OC lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":21682
  },
  {
    "COADD_ID":"CO-ADD:0236946",
    "INHIB_AVE":18.39,
    "SMILES":"O=C1C2=CC(OC)=CC=C2CC\/C1=CC3=CC=CN=C3Cl.Cl",
    "HIT":0.0,
    "question":"Can O=C1C2=CC(OC)=CC=C2CC\/C1=CC3=CC=CN=C3Cl.Cl effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":3986
  },
  {
    "COADD_ID":"CO-ADD:0229637",
    "INHIB_AVE":11.78,
    "SMILES":"c1(cc(n2c3ccc(cc3)OC)c4ccccc4)c2CC(C)(C)CC1=O",
    "HIT":0.0,
    "question":"Can exposure to c1(cc(n2c3ccc(cc3)OC)c4ccccc4)c2CC(C)(C)CC1=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":12884
  },
  {
    "COADD_ID":"CO-ADD:0242796",
    "INHIB_AVE":10.73,
    "SMILES":"n1(nnc(C(=O)N\\N=C\\c2ccccn2)c1CN3CCCCC3)c4nonc4N",
    "HIT":0.0,
    "question":"Is n1(nnc(C(=O)N\\N=C\\c2ccccn2)c1CN3CCCCC3)c4nonc4N effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":15157
  },
  {
    "COADD_ID":"CO-ADD:0248064",
    "INHIB_AVE":1.01,
    "SMILES":"S(c1ccccc1)(=O)(=O)N(c(cc2)ccc2[N+](=O)[O-])CC(=O)N\\N=C(\\c3c(N4)ccc(Br)c3)\/C4=O",
    "HIT":0.0,
    "question":"Does S(c1ccccc1)(=O)(=O)N(c(cc2)ccc2[N+](=O)[O-])CC(=O)N\\N=C(\\c3c(N4)ccc(Br)c3)\/C4=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":53410
  },
  {
    "COADD_ID":"CO-ADD:0240442",
    "INHIB_AVE":20.35,
    "SMILES":"C1(C(OC)=O)=C(C)NC(NC1c2ccc(c(OC)c2)OCC(OCC)=O)=S",
    "HIT":0.0,
    "question":"Can C1(C(OC)=O)=C(C)NC(NC1c2ccc(c(OC)c2)OCC(OCC)=O)=S act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":2671
  },
  {
    "COADD_ID":"CO-ADD:0255607",
    "INHIB_AVE":10.38,
    "SMILES":"C1(=O)C(c2ccccc2)(c3ccc(cc3)OC(C)C)NC(=O)N1",
    "HIT":0.0,
    "question":"Does treatment with C1(=O)C(c2ccccc2)(c3ccc(cc3)OC(C)C)NC(=O)N1 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":16027
  },
  {
    "COADD_ID":"CO-ADD:0258673",
    "INHIB_AVE":-9.06,
    "SMILES":"N1(CC(O)=O)C(=O)\\C(\\SC1=S)=C\/c(cc2)cc(c2OC(c3ccccc3)=O)OCC",
    "HIT":0.0,
    "question":"Does treatment with N1(CC(O)=O)C(=O)\\C(\\SC1=S)=C\/c(cc2)cc(c2OC(c3ccccc3)=O)OCC result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":77916
  },
  {
    "COADD_ID":"CO-ADD:0259818",
    "INHIB_AVE":-15.79,
    "SMILES":"C1(C(OCCCCC)=O)=C(C)NC(NC1c2cccc(c2)OCc3ccccc3)=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C1(C(OCCCCC)=O)=C(C)NC(NC1c2cccc(c2)OCc3ccccc3)=O?",
    "answer":"No",
    "_id":81512
  },
  {
    "COADD_ID":"CO-ADD:0283631",
    "INHIB_AVE":-2.63,
    "SMILES":"c1(SCC(NCCOc(cc2)ccc2Cl)=O)sc3c(ccc(c3)NC(=O)c(cc4)ccc4C(C)(C)C)n1",
    "HIT":0.0,
    "question":"Does treatment with c1(SCC(NCCOc(cc2)ccc2Cl)=O)sc3c(ccc(c3)NC(=O)c(cc4)ccc4C(C)(C)C)n1 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":66206
  },
  {
    "COADD_ID":"CO-ADD:0220180",
    "INHIB_AVE":9.78,
    "SMILES":"C(COc(cc1)ccc1C(C)(C)CC(C)(C)C)(=O)N\\N=C\\c2cccc(Cl)c2",
    "HIT":0.0,
    "question":"Does C(COc(cc1)ccc1C(C)(C)CC(C)(C)C)(=O)N\\N=C\\c2cccc(Cl)c2 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":17616
  },
  {
    "COADD_ID":"CO-ADD:0222557",
    "INHIB_AVE":3.78,
    "SMILES":"c1(ccccc1c2ccccc2)C(NCCOc3ccccc3OC)=O",
    "HIT":0.0,
    "question":"Is c1(ccccc1c2ccccc2)C(NCCOc3ccccc3OC)=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":41167
  },
  {
    "COADD_ID":"CO-ADD:0290769",
    "INHIB_AVE":14.43,
    "SMILES":"C1([N+](=O)[O-])=C(N(CC2)CCN2C=O)c3c(cccc3)OC1=O",
    "HIT":0.0,
    "question":"Does the proposed molecule C1([N+](=O)[O-])=C(N(CC2)CCN2C=O)c3c(cccc3)OC1=O exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":8365
  },
  {
    "COADD_ID":"CO-ADD:0222144",
    "INHIB_AVE":-1.99,
    "SMILES":"c1(c2cccc(cccc3)c23)oc(c4n1)ccc(c4)\\N=C\\c(c(O)ccc5[N+](=O)[O-])c5",
    "HIT":0.0,
    "question":"Is c1(c2cccc(cccc3)c23)oc(c4n1)ccc(c4)\\N=C\\c(c(O)ccc5[N+](=O)[O-])c5 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":64318
  },
  {
    "COADD_ID":"CO-ADD:0310756",
    "INHIB_AVE":-3.17,
    "SMILES":"C(C(OCC)=O)(=CN(c1cc(C)ccc1C)C=C2C(OCC)=O)C2c(ccc(c34)OCO3)c4",
    "HIT":0.0,
    "question":"Does C(C(OCC)=O)(=CN(c1cc(C)ccc1C)C=C2C(OCC)=O)C2c(ccc(c34)OCO3)c4 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":67704
  },
  {
    "COADD_ID":"CO-ADD:0217949",
    "INHIB_AVE":7.4,
    "SMILES":"C(=O)(N\\N=C\\c(cccn1)c1)C(C)Oc2cccc(cccc3)c23",
    "HIT":0.0,
    "question":"Does C(=O)(N\\N=C\\c(cccn1)c1)C(C)Oc2cccc(cccc3)c23 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":25474
  },
  {
    "COADD_ID":"CO-ADD:0255543",
    "INHIB_AVE":-21.86,
    "SMILES":"c(\\C=N\\N=C\\c(cc(Br)c(c1)OC)c1OC)(cc(Br)c(c2)OC)c2OC",
    "HIT":0.0,
    "question":"Can c(\\C=N\\N=C\\c(cc(Br)c(c1)OC)c1OC)(cc(Br)c(c2)OC)c2OC effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":82310
  },
  {
    "COADD_ID":"CO-ADD:0321506",
    "INHIB_AVE":-0.05,
    "SMILES":"N1(C(=O)c2cccc(Cl)c2)C(C)(C)C=C(c(cc(cc3)OC(c4ccccc4)=O)c13)C",
    "HIT":0.0,
    "question":"Does N1(C(=O)c2cccc(Cl)c2)C(C)(C)C=C(c(cc(cc3)OC(c4ccccc4)=O)c13)C show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":57683
  },
  {
    "COADD_ID":"CO-ADD:0232176",
    "INHIB_AVE":13.5,
    "SMILES":"c1(c(Br)cc(cc1\\C=N\\NC(=O)c(ccc(n2)C)c2)Br)OC(=O)c3cccc(Br)c3",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(c(Br)cc(cc1\\C=N\\NC(=O)c(ccc(n2)C)c2)Br)OC(=O)c3cccc(Br)c3?",
    "answer":"No",
    "_id":9762
  },
  {
    "COADD_ID":"CO-ADD:0286221",
    "INHIB_AVE":14.36,
    "SMILES":"[N+](=O)([O-])c1ccc(cc1)\\C=N\\Nc(cc2)ncc2C(F)(F)F",
    "HIT":0.0,
    "question":"Can [N+](=O)([O-])c1ccc(cc1)\\C=N\\Nc(cc2)ncc2C(F)(F)F act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":8469
  },
  {
    "COADD_ID":"CO-ADD:0291688",
    "INHIB_AVE":-8.49,
    "SMILES":"c1(NC(C)=O)sc2c(ccc(Br)c2OCC(O)CN(CC)CC)c1C(OCC)=O",
    "HIT":0.0,
    "question":"Does c1(NC(C)=O)sc2c(ccc(Br)c2OCC(O)CN(CC)CC)c1C(OCC)=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":77280
  },
  {
    "COADD_ID":"CO-ADD:0232583",
    "INHIB_AVE":10.58,
    "SMILES":"C(=O)(N\\N=C\\c1ccccn1)c2ccccn2",
    "HIT":0.0,
    "question":"Does the proposed molecule C(=O)(N\\N=C\\c1ccccn1)c2ccccn2 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":15527
  },
  {
    "COADD_ID":"CO-ADD:0329004",
    "INHIB_AVE":-1.1,
    "SMILES":"C1(c2c(N3Cc4ccccc4F)cccc2)(NC(C(C(N5c6cccc(Cl)c6)=O)C1C5=O)CC(C)C)C3=O",
    "HIT":0.0,
    "question":"Does the proposed molecule C1(c2c(N3Cc4ccccc4F)cccc2)(NC(C(C(N5c6cccc(Cl)c6)=O)C1C5=O)CC(C)C)C3=O exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":61427
  },
  {
    "COADD_ID":"CO-ADD:0252296",
    "INHIB_AVE":1.08,
    "SMILES":"S(NCCCCCCCCCCCCCCCCCC)(=O)(=O)c(cccc1C(=O)Nc(cc2)ccc2Br)c1",
    "HIT":0.0,
    "question":"Does S(NCCCCCCCCCCCCCCCCCC)(=O)(=O)c(cccc1C(=O)Nc(cc2)ccc2Br)c1 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":53124
  },
  {
    "COADD_ID":"CO-ADD:0220093",
    "INHIB_AVE":-2.13,
    "SMILES":"C1(c2ccco2)N(CCN1c3cccc(C)c3)c4cccc(C)c4",
    "HIT":0.0,
    "question":"Can C1(c2ccco2)N(CCN1c3cccc(C)c3)c4cccc(C)c4 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":64737
  },
  {
    "COADD_ID":"CO-ADD:0163575",
    "INHIB_AVE":6.95,
    "SMILES":"c1(ccc(\\C=N\\NC(=O)Cc2cccc(cccc3)c23)o1)c4ccc(cc4Cl)Cl",
    "HIT":0.0,
    "question":"Does the proposed molecule c1(ccc(\\C=N\\NC(=O)Cc2cccc(cccc3)c23)o1)c4ccc(cc4Cl)Cl exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":27199
  },
  {
    "COADD_ID":"CO-ADD:0244247",
    "INHIB_AVE":24.1,
    "SMILES":"[N+](=O)([O-])c(cc(cc1[N+](=O)[O-])C(=O)Oc(cc2)ccc2\\C=N\\NC(=O)CC(=O)N\\N=C\\c(cc3)ccc3OC(=O)c(cc(cc4[N+](=O)[O-])[N+](=O)[O-])c4)c1",
    "HIT":0.0,
    "question":"Is [N+](=O)([O-])c(cc(cc1[N+](=O)[O-])C(=O)Oc(cc2)ccc2\\C=N\\NC(=O)CC(=O)N\\N=C\\c(cc3)ccc3OC(=O)c(cc(cc4[N+](=O)[O-])[N+](=O)[O-])c4)c1 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":1325
  },
  {
    "COADD_ID":"CO-ADD:0278056",
    "INHIB_AVE":7.26,
    "SMILES":"c1(N2CCC(CC2)C)nc(Cl)nc(Nc(ccc(c34)OCO3)c4)n1",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(N2CCC(CC2)C)nc(Cl)nc(Nc(ccc(c34)OCO3)c4)n1?",
    "answer":"No",
    "_id":26009
  },
  {
    "COADD_ID":"CO-ADD:0226981",
    "INHIB_AVE":5.0,
    "SMILES":"N1(c(ccs2)c2C(N3Cc4cccs4)=O)C3=NN(CC(NCCC)=O)C1=O",
    "HIT":0.0,
    "question":"Does the proposed molecule N1(c(ccs2)c2C(N3Cc4cccs4)=O)C3=NN(CC(NCCC)=O)C1=O exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":35626
  },
  {
    "COADD_ID":"CO-ADD:0162866",
    "INHIB_AVE":-13.06,
    "SMILES":"C(\/O)(\\c1ccc(cc1)Br)=C\/C=N\/c2cccc(Cl)c2",
    "HIT":0.0,
    "question":"Is C(\/O)(\\c1ccc(cc1)Br)=C\/C=N\/c2cccc(Cl)c2 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":80548
  },
  {
    "COADD_ID":"CO-ADD:0289271",
    "INHIB_AVE":3.47,
    "SMILES":"C(CC(CC1)CCN1)(=O)NCc2cccc(C)c2.Cl",
    "HIT":0.0,
    "question":"Does C(CC(CC1)CCN1)(=O)NCc2cccc(C)c2.Cl demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":42523
  },
  {
    "COADD_ID":"CO-ADD:0242885",
    "INHIB_AVE":0.14,
    "SMILES":"N1(c2ccc(cc2)F)CC(CC1=O)C(=O)Nc3cccc(C)c3C",
    "HIT":0.0,
    "question":"Does N1(c2ccc(cc2)F)CC(CC1=O)C(=O)Nc3cccc(C)c3C demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":56944
  },
  {
    "COADD_ID":"CO-ADD:0160579",
    "INHIB_AVE":11.06,
    "SMILES":"O=C(CNC1=CC=CC(Br)=C1)NN=C2CCCCCC2",
    "HIT":0.0,
    "question":"Does the proposed molecule O=C(CNC1=CC=CC(Br)=C1)NN=C2CCCCCC2 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":14400
  },
  {
    "COADD_ID":"CO-ADD:0260005",
    "INHIB_AVE":-4.16,
    "SMILES":"c1(cc(ccc1Oc2ccccc2C(=O)Nc(cccc3C(F)(F)F)c3)C(F)(F)F)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Can c1(cc(ccc1Oc2ccccc2C(=O)Nc(cccc3C(F)(F)F)c3)C(F)(F)F)[N+](=O)[O-] effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":70111
  },
  {
    "COADD_ID":"CO-ADD:0323819",
    "INHIB_AVE":2.03,
    "SMILES":"N1(C(C)(C)CC(CC1(C)C)OC(c2ccccc2)=O)OC(=O)c(cc3)ccc3n4cnnn4",
    "HIT":0.0,
    "question":"Does N1(C(C)(C)CC(CC1(C)C)OC(c2ccccc2)=O)OC(=O)c(cc3)ccc3n4cnnn4 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":48955
  },
  {
    "COADD_ID":"CO-ADD:0294064",
    "INHIB_AVE":0.56,
    "SMILES":"N(C(=O)\\C(\\S1)=C\\c2cc(OC)ccc2OC)=C1N3CCCCCC3",
    "HIT":0.0,
    "question":"Does the proposed molecule N(C(=O)\\C(\\S1)=C\\c2cc(OC)ccc2OC)=C1N3CCCCCC3 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":55284
  },
  {
    "COADD_ID":"CO-ADD:0220390",
    "INHIB_AVE":3.87,
    "SMILES":"c1(NCC(=O)N\\N=C\\c(cc2)ccc2Br)c(Br)cc(cc1Br)Br",
    "HIT":0.0,
    "question":"Does the proposed molecule c1(NCC(=O)N\\N=C\\c(cc2)ccc2Br)c(Br)cc(cc1Br)Br exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":40778
  },
  {
    "COADD_ID":"CO-ADD:0247520",
    "INHIB_AVE":8.63,
    "SMILES":"N1(\\N=C\\c(ccc(c2OCC)OCc(cc3)ccc3[N+](=O)[O-])c2)C(=O)C4C(C5C6(CC6)C4C=C5)C1=O",
    "HIT":0.0,
    "question":"Does N1(\\N=C\\c(ccc(c2OCC)OCc(cc3)ccc3[N+](=O)[O-])c2)C(=O)C4C(C5C6(CC6)C4C=C5)C1=O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":21052
  },
  {
    "COADD_ID":"CO-ADD:0305669",
    "INHIB_AVE":-1.55,
    "SMILES":"C(C(=O)Nc(cc1)ccc1Cl)(=C(C)NC(=C2C#N)SCC(=O)Nc(cc3)ccc3I)C2c4ccccc4",
    "HIT":0.0,
    "question":"Does treatment with C(C(=O)Nc(cc1)ccc1Cl)(=C(C)NC(=C2C#N)SCC(=O)Nc(cc3)ccc3I)C2c4ccccc4 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":62889
  },
  {
    "COADD_ID":"CO-ADD:0257194",
    "INHIB_AVE":-2.82,
    "SMILES":"[N+](=O)([O-])c(c(C)c1)cc(c1N(CC2)CCN2C(=O)c3c(cccc3F)F)F",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound [N+](=O)([O-])c(c(C)c1)cc(c1N(CC2)CCN2C(=O)c3c(cccc3F)F)F?",
    "answer":"No",
    "_id":66746
  },
  {
    "COADD_ID":"CO-ADD:0149413",
    "INHIB_AVE":4.03,
    "SMILES":"c(C1C(C#N)=C(N)Oc(cc2OC)c1cc2)(c(OC)c3)ccc3OC",
    "HIT":0.0,
    "question":"Can c(C1C(C#N)=C(N)Oc(cc2OC)c1cc2)(c(OC)c3)ccc3OC act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":40037
  },
  {
    "COADD_ID":"CO-ADD:0293991",
    "INHIB_AVE":9.6,
    "SMILES":"S(=O)(=O)(CCc1sc(c2n1)cccc2)c3ccc(cc3)Br",
    "HIT":0.0,
    "question":"Is S(=O)(=O)(CCc1sc(c2n1)cccc2)c3ccc(cc3)Br capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":18134
  },
  {
    "COADD_ID":"CO-ADD:0302445",
    "INHIB_AVE":5.45,
    "SMILES":"c12c(c3c(CCCC3)nc1N)C(N(CCCCC)C2=N)=O",
    "HIT":0.0,
    "question":"Does c12c(c3c(CCCC3)nc1N)C(N(CCCCC)C2=N)=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":33671
  },
  {
    "COADD_ID":"CO-ADD:0245443",
    "INHIB_AVE":24.47,
    "SMILES":"n1(c2c(n3)cccc2)c3S\\C(=C\/c(ccc4c(cc5)c(OC)cc5[N+](=O)[O-])o4)\\C1=O.Cl.Cl",
    "HIT":0.0,
    "question":"Does n1(c2c(n3)cccc2)c3S\\C(=C\/c(ccc4c(cc5)c(OC)cc5[N+](=O)[O-])o4)\\C1=O.Cl.Cl show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":1253
  },
  {
    "COADD_ID":"CO-ADD:0332544",
    "INHIB_AVE":9.04,
    "SMILES":"c1(ccc(cc1N(CC2)CCO2)N(CC3)CCN3C(=O)c4ccccc4C)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Does c1(ccc(cc1N(CC2)CCO2)N(CC3)CCN3C(=O)c4ccccc4C)[N+](=O)[O-] show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":19758
  },
  {
    "COADD_ID":"CO-ADD:0304080",
    "INHIB_AVE":39.07,
    "SMILES":"c1(CC(NCCO)=O)n(C)c2c(cc(cc2)C)c1Sc3ccccc3",
    "HIT":0.0,
    "question":"Can c1(CC(NCCO)=O)n(C)c2c(cc(cc2)C)c1Sc3ccccc3 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":560
  },
  {
    "COADD_ID":"CO-ADD:0254450",
    "INHIB_AVE":8.62,
    "SMILES":"C1(c2ccccc2)(c3ccccc3)OC(CCc4ccc(C)o4)Nc(cccc5)c15",
    "HIT":0.0,
    "question":"Can C1(c2ccccc2)(c3ccccc3)OC(CCc4ccc(C)o4)Nc(cccc5)c15 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":21099
  },
  {
    "COADD_ID":"CO-ADD:0292233",
    "INHIB_AVE":3.35,
    "SMILES":"n1(c2ccccc2)c(COc(cc3)ccc3C(C)(C)C)nnc1SCC(=O)Nc(ccc(c4s5)nc5SCC(=O)Nc(cc6)ccc6F)c4",
    "HIT":0.0,
    "question":"Does treatment with n1(c2ccccc2)c(COc(cc3)ccc3C(C)(C)C)nnc1SCC(=O)Nc(ccc(c4s5)nc5SCC(=O)Nc(cc6)ccc6F)c4 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":43023
  },
  {
    "COADD_ID":"CO-ADD:0220256",
    "INHIB_AVE":9.63,
    "SMILES":"[N+](=O)([O-])c1ccc(c(Br)c1)OCC(=O)N\\N=C(\/C)\\c2ccc(cc2)CC",
    "HIT":0.0,
    "question":"Can [N+](=O)([O-])c1ccc(c(Br)c1)OCC(=O)N\\N=C(\/C)\\c2ccc(cc2)CC effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":18059
  },
  {
    "COADD_ID":"CO-ADD:0228449",
    "INHIB_AVE":10.62,
    "SMILES":"S(=O)(=O)(c1ccc(c2c1)cccc2)N3CCSC3c4ccccc4",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound S(=O)(=O)(c1ccc(c2c1)cccc2)N3CCSC3c4ccccc4?",
    "answer":"No",
    "_id":15435
  },
  {
    "COADD_ID":"CO-ADD:0278724",
    "INHIB_AVE":-1.38,
    "SMILES":"c1(SCC(NCCOc2ccccc2)=O)sc3c(ccc(c3)\\N=C\\c(cc4)ccc4Cl)n1",
    "HIT":0.0,
    "question":"Does c1(SCC(NCCOc2ccccc2)=O)sc3c(ccc(c3)\\N=C\\c(cc4)ccc4Cl)n1 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":62339
  },
  {
    "COADD_ID":"CO-ADD:0295442",
    "INHIB_AVE":5.64,
    "SMILES":"c1(cc(ccc1Cl)NC(Cc(cc2)ccc2F)=O)C(F)(F)F",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(cc(ccc1Cl)NC(Cc(cc2)ccc2F)=O)C(F)(F)F?",
    "answer":"No",
    "_id":32735
  },
  {
    "COADD_ID":"CO-ADD:0218560",
    "INHIB_AVE":8.37,
    "SMILES":"C(OCCCCCCCCC)(NCCCCNC(OCCCCCCCCC)=O)=O",
    "HIT":0.0,
    "question":"Does C(OCCCCCCCCC)(NCCCCNC(OCCCCCCCCC)=O)=O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":21892
  },
  {
    "COADD_ID":"CO-ADD:0303801",
    "INHIB_AVE":-1.56,
    "SMILES":"[N+](=O)([O-])c1ccc(cc1NCc2ccccc2)N(CC3)CCN3C(=O)c4ccccc4Br",
    "HIT":0.0,
    "question":"Does the proposed molecule [N+](=O)([O-])c1ccc(cc1NCc2ccccc2)N(CC3)CCN3C(=O)c4ccccc4Br exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":62948
  },
  {
    "COADD_ID":"CO-ADD:0324735",
    "INHIB_AVE":-10.94,
    "SMILES":"C12=C(CC(C)(C)CC1=O)Nc(c3NC2c4ccccc4Cl)cc(c(C)c3)C",
    "HIT":0.0,
    "question":"Does the proposed molecule C12=C(CC(C)(C)CC1=O)Nc(c3NC2c4ccccc4Cl)cc(c(C)c3)C exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":79390
  },
  {
    "COADD_ID":"CO-ADD:0258117",
    "INHIB_AVE":-0.28,
    "SMILES":"C(=N\/c1cccc(C)c1)(\/S\\C(\\C2=O)=C\\c(ccc(c3OC)OCc4cccc(C)c4)c3)\\N2",
    "HIT":0.0,
    "question":"Does treatment with C(=N\/c1cccc(C)c1)(\/S\\C(\\C2=O)=C\\c(ccc(c3OC)OCc4cccc(C)c4)c3)\\N2 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":58541
  },
  {
    "COADD_ID":"CO-ADD:0241431",
    "INHIB_AVE":-5.6,
    "SMILES":"c1(N(CC2)CCO2)nc(N\\N=C\\c3ccc(cc3OC)OC)nc(Nc(cc4)ccc4F)n1.Cl",
    "HIT":0.0,
    "question":"Does treatment with c1(N(CC2)CCO2)nc(N\\N=C\\c3ccc(cc3OC)OC)nc(Nc(cc4)ccc4F)n1.Cl result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":73007
  },
  {
    "COADD_ID":"CO-ADD:0258401",
    "INHIB_AVE":1.94,
    "SMILES":"P(OCC)(OCC)(=O)c1ccccc1OC(=O)c(cccc2[N+](=O)[O-])c2",
    "HIT":0.0,
    "question":"Can exposure to P(OCC)(OCC)(=O)c1ccccc1OC(=O)c(cccc2[N+](=O)[O-])c2 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":49392
  },
  {
    "COADD_ID":"CO-ADD:0292202",
    "INHIB_AVE":-0.42,
    "SMILES":"n1c(c(cccc2[N+](=O)[O-])c2)[nH]c(c3ccccc3)c1c(cc4)ccc4c(cc5)ccc5[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Can n1c(c(cccc2[N+](=O)[O-])c2)[nH]c(c3ccccc3)c1c(cc4)ccc4c(cc5)ccc5[N+](=O)[O-] effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":59079
  },
  {
    "COADD_ID":"CO-ADD:0286775",
    "INHIB_AVE":13.16,
    "SMILES":"C(C#N)(C1c2ccc(cc2)F)=C(N)N(C(CC(C)(C)CC3=O)=C13)c4cccc(Br)c4",
    "HIT":0.0,
    "question":"Can C(C#N)(C1c2ccc(cc2)F)=C(N)N(C(CC(C)(C)CC3=O)=C13)c4cccc(Br)c4 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":10317
  },
  {
    "COADD_ID":"CO-ADD:0163065",
    "INHIB_AVE":6.94,
    "SMILES":"C(=O)(N\\N=C\\c(ccc1I)o1)c2ccco2",
    "HIT":0.0,
    "question":"Does treatment with C(=O)(N\\N=C\\c(ccc1I)o1)c2ccco2 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":27236
  },
  {
    "COADD_ID":"CO-ADD:0219307",
    "INHIB_AVE":7.45,
    "SMILES":"c1(ccccc1NC(=O)c2ccc(cc2)F)C(=O)N\\N=C\\C=C\\c3ccccc3",
    "HIT":0.0,
    "question":"Does treatment with c1(ccccc1NC(=O)c2ccc(cc2)F)C(=O)N\\N=C\\C=C\\c3ccccc3 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":25247
  },
  {
    "COADD_ID":"CO-ADD:0159979",
    "INHIB_AVE":-3.44,
    "SMILES":"[O-][N+](C1=CC=CC(\/C=N\/N=C(S\/2)\\NC(C2=C\\C3=CC=CC=C3O)=O)=C1)=O",
    "HIT":0.0,
    "question":"Does the proposed molecule [O-][N+](C1=CC=CC(\/C=N\/N=C(S\/2)\\NC(C2=C\\C3=CC=CC=C3O)=O)=C1)=O exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":68355
  },
  {
    "COADD_ID":"CO-ADD:0155512",
    "INHIB_AVE":8.02,
    "SMILES":"N#CC1=C(NC(C2=CC=C(OC)C=C2)=O)SC3=C1CCCCC3",
    "HIT":0.0,
    "question":"Does N#CC1=C(NC(C2=CC=C(OC)C=C2)=O)SC3=C1CCCCC3 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":23139
  },
  {
    "COADD_ID":"CO-ADD:0299812",
    "INHIB_AVE":2.37,
    "SMILES":"N1(c2ccccc2F)C(=O)NC(\\C(=C\/c3cc(OC)ccc3OC)\\C1=O)=O",
    "HIT":0.0,
    "question":"Can exposure to N1(c2ccccc2F)C(=O)NC(\\C(=C\/c3cc(OC)ccc3OC)\\C1=O)=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":47463
  },
  {
    "COADD_ID":"CO-ADD:0285057",
    "INHIB_AVE":-0.17,
    "SMILES":"n1(c(C)c(c(C)n1)Br)C(=O)c2c(Br)cnn2C",
    "HIT":0.0,
    "question":"Does treatment with n1(c(C)c(c(C)n1)Br)C(=O)c2c(Br)cnn2C result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":58148
  },
  {
    "COADD_ID":"CO-ADD:0283277",
    "INHIB_AVE":4.5,
    "SMILES":"C(C#N)(\\C(=C(\\C#N)\/C#N)\\NC(=C1C#N)N)=C1c2ccccc2I",
    "HIT":0.0,
    "question":"Does the proposed molecule C(C#N)(\\C(=C(\\C#N)\/C#N)\\NC(=C1C#N)N)=C1c2ccccc2I exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":37948
  },
  {
    "COADD_ID":"CO-ADD:0162246",
    "INHIB_AVE":3.59,
    "SMILES":"c1(N(CC2)CCO2)nc(N\\N=C\\c3cc(Br)ccc3O)nc(Nc4cc(C)ccc4C)n1",
    "HIT":0.0,
    "question":"Does c1(N(CC2)CCO2)nc(N\\N=C\\c3cc(Br)ccc3O)nc(Nc4cc(C)ccc4C)n1 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":41982
  },
  {
    "COADD_ID":"CO-ADD:0326561",
    "INHIB_AVE":-0.24,
    "SMILES":"n12c(c(cn1)C#N)nc(c3c2C(F)(F)F)CCCC3",
    "HIT":0.0,
    "question":"Can n12c(c(cn1)C#N)nc(c3c2C(F)(F)F)CCCC3 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":58381
  },
  {
    "COADD_ID":"CO-ADD:0255817",
    "INHIB_AVE":-2.14,
    "SMILES":"N1(c(cc2)ccc2\\C(\\O)=C(\\C#N)\/C(OCC)=O)C(=O)c(c3C1=O)ccc(C(O)=O)c3",
    "HIT":0.0,
    "question":"Does N1(c(cc2)ccc2\\C(\\O)=C(\\C#N)\/C(OCC)=O)C(=O)c(c3C1=O)ccc(C(O)=O)c3 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":64780
  },
  {
    "COADD_ID":"CO-ADD:0218213",
    "INHIB_AVE":11.68,
    "SMILES":"c1(cc(Br)ccc1O)C(=O)N\\N=C\\c2ccccc2OC",
    "HIT":0.0,
    "question":"Does the proposed molecule c1(cc(Br)ccc1O)C(=O)N\\N=C\\c2ccccc2OC exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":13084
  },
  {
    "COADD_ID":"CO-ADD:0287334",
    "INHIB_AVE":14.28,
    "SMILES":"C12=C(C(N(c3ccccc3)C1=O)c4ccc(cc4)Br)\\C(\\C(=O)N2c5ccccc5)=C\\c(cc6)ccc6F",
    "HIT":0.0,
    "question":"Does the proposed molecule C12=C(C(N(c3ccccc3)C1=O)c4ccc(cc4)Br)\\C(\\C(=O)N2c5ccccc5)=C\\c(cc6)ccc6F exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":8604
  },
  {
    "COADD_ID":"CO-ADD:0304152",
    "INHIB_AVE":3.17,
    "SMILES":"C(C(OC)=O)(=CN(Cc(cc1)ccc1F)C=C2C(OC)=O)C2c3ccc(cc3)Cl",
    "HIT":0.0,
    "question":"Does the proposed molecule C(C(OC)=O)(=CN(Cc(cc1)ccc1F)C=C2C(OC)=O)C2c3ccc(cc3)Cl exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":43852
  },
  {
    "COADD_ID":"CO-ADD:0304539",
    "INHIB_AVE":3.29,
    "SMILES":"c(c(C)nc(c1C#N)SCC(N)=O)(C(=O)Nc2ccccc2C)c1c3ccc(cc3)F",
    "HIT":0.0,
    "question":"Does c(c(C)nc(c1C#N)SCC(N)=O)(C(=O)Nc2ccccc2C)c1c3ccc(cc3)F show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":43305
  },
  {
    "COADD_ID":"CO-ADD:0227066",
    "INHIB_AVE":3.05,
    "SMILES":"C(=O)(c1ccc(cc1)Br)Nc(cc2)ccc2N(C)C",
    "HIT":0.0,
    "question":"Does C(=O)(c1ccc(cc1)Br)Nc(cc2)ccc2N(C)C demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":44409
  },
  {
    "COADD_ID":"CO-ADD:0243874",
    "INHIB_AVE":10.86,
    "SMILES":"C1=C(C)OC(=O)C(C(c(cc(OCO2)c23)cc3OC)CC(=O)Nc(cc4)cc(OC)c4)=C1O",
    "HIT":0.0,
    "question":"Can C1=C(C)OC(=O)C(C(c(cc(OCO2)c23)cc3OC)CC(=O)Nc(cc4)cc(OC)c4)=C1O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":14848
  },
  {
    "COADD_ID":"CO-ADD:0294943",
    "INHIB_AVE":13.98,
    "SMILES":"C1(=Cc2c(OC1=O)cccc2)c3[nH]c4c(ccc(C)c4)n3",
    "HIT":0.0,
    "question":"Can C1(=Cc2c(OC1=O)cccc2)c3[nH]c4c(ccc(C)c4)n3 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":9062
  },
  {
    "COADD_ID":"CO-ADD:0242230",
    "INHIB_AVE":20.43,
    "SMILES":"c1(O)c(OCC)cc(cc1I)\\C=N\\NC(=O)c(cccn2)c2",
    "HIT":0.0,
    "question":"Does c1(O)c(OCC)cc(cc1I)\\C=N\\NC(=O)c(cccn2)c2 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":2631
  },
  {
    "COADD_ID":"CO-ADD:0236130",
    "INHIB_AVE":4.97,
    "SMILES":"N1(c2ccc(cc2)OCCC)C(=O)CC(N(CC3)CCC3C(O)=O)C1=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound N1(c2ccc(cc2)OCCC)C(=O)CC(N(CC3)CCC3C(O)=O)C1=O?",
    "answer":"No",
    "_id":35785
  },
  {
    "COADD_ID":"CO-ADD:0277764",
    "INHIB_AVE":7.76,
    "SMILES":"n1(CC(c2ccccc2)=O)c(c3ccccc3)nnc1c4ccccc4",
    "HIT":0.0,
    "question":"Does treatment with n1(CC(c2ccccc2)=O)c(c3ccccc3)nnc1c4ccccc4 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":24116
  },
  {
    "COADD_ID":"CO-ADD:0301805",
    "INHIB_AVE":1.2,
    "SMILES":"C1(CC(=O)Nc(ccc(cccc2)c23)c13)c4ccccc4C(F)(F)F",
    "HIT":0.0,
    "question":"Can exposure to C1(CC(=O)Nc(ccc(cccc2)c23)c13)c4ccccc4C(F)(F)F lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":52626
  },
  {
    "COADD_ID":"CO-ADD:0155591",
    "INHIB_AVE":8.05,
    "SMILES":"CC1=NN(C2=CC=CC=C2)C(\/N=C\/C3=CC(Br)=CC=C3O)=C1C4=CC(Br)=CC=C4",
    "HIT":0.0,
    "question":"Does the proposed molecule CC1=NN(C2=CC=CC=C2)C(\/N=C\/C3=CC(Br)=CC=C3O)=C1C4=CC(Br)=CC=C4 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":23003
  },
  {
    "COADD_ID":"CO-ADD:0288771",
    "INHIB_AVE":-4.4,
    "SMILES":"C12(OCCC(C1)CC(NCc3cnccc3)=O)CCN(CC2)C(c(c4)oc([N+](=O)[O-])c4)=O",
    "HIT":0.0,
    "question":"Is C12(OCCC(C1)CC(NCc3cnccc3)=O)CCN(CC2)C(c(c4)oc([N+](=O)[O-])c4)=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":70617
  },
  {
    "COADD_ID":"CO-ADD:0293396",
    "INHIB_AVE":2.41,
    "SMILES":"C1(N2)=C(C(C3=C2c4c(C3=O)cccc4)c5ccc(cc5Cl)Cl)C(NC(=O)N1C)=O",
    "HIT":0.0,
    "question":"Does C1(N2)=C(C(C3=C2c4c(C3=O)cccc4)c5ccc(cc5Cl)Cl)C(NC(=O)N1C)=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":47249
  },
  {
    "COADD_ID":"CO-ADD:0155872",
    "INHIB_AVE":3.64,
    "SMILES":"O=C(N(C1CCCCC1)C2CCCCC2)C(C=CC=C3)=C3C(NC(CC(C)C)C(OCCCC)=O)=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound O=C(N(C1CCCCC1)C2CCCCC2)C(C=CC=C3)=C3C(NC(CC(C)C)C(OCCCC)=O)=O?",
    "answer":"No",
    "_id":41807
  },
  {
    "COADD_ID":"CO-ADD:0237050",
    "INHIB_AVE":1.43,
    "SMILES":"Cc1nn2C(=O)C3=C(CCCC3)Nc2c1c4ccc(Cl)cc4",
    "HIT":0.0,
    "question":"Is Cc1nn2C(=O)C3=C(CCCC3)Nc2c1c4ccc(Cl)cc4 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":51622
  },
  {
    "COADD_ID":"CO-ADD:0230252",
    "INHIB_AVE":14.88,
    "SMILES":"c1(OC)cc(OC)ccc1\\C=N\\NC(CCCCCCC)=O",
    "HIT":0.0,
    "question":"Can c1(OC)cc(OC)ccc1\\C=N\\NC(CCCCCCC)=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":7741
  },
  {
    "COADD_ID":"CO-ADD:0222547",
    "INHIB_AVE":7.59,
    "SMILES":"N(=C\\c(cc(Cl)cc1Cl)c1O)\/c2c(C)cccc2O",
    "HIT":0.0,
    "question":"Is N(=C\\c(cc(Cl)cc1Cl)c1O)\/c2c(C)cccc2O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":24726
  },
  {
    "COADD_ID":"CO-ADD:0137675",
    "INHIB_AVE":-0.93,
    "SMILES":"C12(C)N(CCc(cccc3)c13)C(OC2(CC4(C)C)CC(N4)(C)C)=O",
    "HIT":0.0,
    "question":"Is C12(C)N(CCc(cccc3)c13)C(OC2(CC4(C)C)CC(N4)(C)C)=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":60879
  },
  {
    "COADD_ID":"CO-ADD:0164602",
    "INHIB_AVE":99.45,
    "SMILES":"C[C@H]1COc2c(N3CCN(C)CC3)c(F)cc3c2n1cc(C(O)=O)c3=O",
    "HIT":1.0,
    "question":"Can C[C@H]1COc2c(N3CCN(C)CC3)c(F)cc3c2n1cc(C(O)=O)c3=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"Yes",
    "_id":138
  },
  {
    "COADD_ID":"CO-ADD:0162763",
    "INHIB_AVE":0.26,
    "SMILES":"N(=C\\c1cccc(Br)c1)\/NC(CCC(=O)Nc(cc2)ccc2CC)=O",
    "HIT":0.0,
    "question":"Does N(=C\\c1cccc(Br)c1)\/NC(CCC(=O)Nc(cc2)ccc2CC)=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":56409
  },
  {
    "COADD_ID":"CO-ADD:0289213",
    "INHIB_AVE":14.39,
    "SMILES":"n1c(C)onc1C(CC2)CCN2.Cl",
    "HIT":0.0,
    "question":"Is n1c(C)onc1C(CC2)CCN2.Cl capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":8435
  },
  {
    "COADD_ID":"CO-ADD:0287406",
    "INHIB_AVE":-0.19,
    "SMILES":"N1(C2c3cccc(OC)c3)C(S\\C(=C\/c(ccc4c5cc(Cl)ccc5C)o4)\\C1=O)=NC(C)=C2C(OCC)=O",
    "HIT":0.0,
    "question":"Does N1(C2c3cccc(OC)c3)C(S\\C(=C\/c(ccc4c5cc(Cl)ccc5C)o4)\\C1=O)=NC(C)=C2C(OCC)=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":58215
  },
  {
    "COADD_ID":"CO-ADD:0234744",
    "INHIB_AVE":1.39,
    "SMILES":"C(=O)(Oc1ccc(cc1\\C=N\\NC(CNc2cccc(C)c2)=O)Br)c3ccccc3Cl",
    "HIT":0.0,
    "question":"Can C(=O)(Oc1ccc(cc1\\C=N\\NC(CNc2cccc(C)c2)=O)Br)c3ccccc3Cl effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":51777
  },
  {
    "COADD_ID":"CO-ADD:0278382",
    "INHIB_AVE":1.98,
    "SMILES":"N1(CC(=O)Nc(ncc2[N+](=O)[O-])s2)C(=O)c(c3C1=O)cccc3[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound N1(CC(=O)Nc(ncc2[N+](=O)[O-])s2)C(=O)c(c3C1=O)cccc3[N+](=O)[O-]?",
    "answer":"No",
    "_id":49199
  },
  {
    "COADD_ID":"CO-ADD:0222928",
    "INHIB_AVE":5.86,
    "SMILES":"S(=O)(=O)(Nc(cc1)ccc1I)c(cccc2[N+](=O)[O-])c2",
    "HIT":0.0,
    "question":"Does the proposed molecule S(=O)(=O)(Nc(cc1)ccc1I)c(cccc2[N+](=O)[O-])c2 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":31849
  },
  {
    "COADD_ID":"CO-ADD:0222209",
    "INHIB_AVE":0.61,
    "SMILES":"c1(cc(Br)cc(\\C=N\\c(ccc(c2o3)nc3c4ccc(c5c4)cccc5)c2)c1O)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Does c1(cc(Br)cc(\\C=N\\c(ccc(c2o3)nc3c4ccc(c5c4)cccc5)c2)c1O)[N+](=O)[O-] demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":55064
  },
  {
    "COADD_ID":"CO-ADD:0331797",
    "INHIB_AVE":7.05,
    "SMILES":"c1(nonc1N)\\C(\\N)=N\\N=C(\\C)\/c2ccc(cc2O)O",
    "HIT":0.0,
    "question":"Can exposure to c1(nonc1N)\\C(\\N)=N\\N=C(\\C)\/c2ccc(cc2O)O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":26766
  },
  {
    "COADD_ID":"CO-ADD:0235315",
    "INHIB_AVE":7.84,
    "SMILES":"C(=O)(C(c1ccccc1)c2ccccc2)NC(Cc(c3c([nH]4)cccc3)c4)C(OC)=O",
    "HIT":0.0,
    "question":"Does the proposed molecule C(=O)(C(c1ccccc1)c2ccccc2)NC(Cc(c3c([nH]4)cccc3)c4)C(OC)=O exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":23810
  },
  {
    "COADD_ID":"CO-ADD:0256156",
    "INHIB_AVE":1.05,
    "SMILES":"C(=N\/c1ccccc1)(\/S\\C(\\C2=O)=C\/c3cc(OC)ccc3OC)\\N2",
    "HIT":0.0,
    "question":"Can C(=N\/c1ccccc1)(\/S\\C(\\C2=O)=C\/c3cc(OC)ccc3OC)\\N2 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":53229
  },
  {
    "COADD_ID":"CO-ADD:0279141",
    "INHIB_AVE":5.31,
    "SMILES":"c1(C2=O)c(c(c(Cl)c(Cl)c1Cl)Cl)C(N2CCC(O)=O)=O",
    "HIT":0.0,
    "question":"Can exposure to c1(C2=O)c(c(c(Cl)c(Cl)c1Cl)Cl)C(N2CCC(O)=O)=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":34293
  },
  {
    "COADD_ID":"CO-ADD:0136011",
    "INHIB_AVE":-1.89,
    "SMILES":"O1C(CN(CC(O)=O)C)=C(O)C(C=C1CO)=O",
    "HIT":0.0,
    "question":"Does the proposed molecule O1C(CN(CC(O)=O)C)=C(O)C(C=C1CO)=O exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":64029
  },
  {
    "COADD_ID":"CO-ADD:0237349",
    "INHIB_AVE":-7.13,
    "SMILES":"NS(=O)(=O)c1cncc(c1)c2ccc3nccc(c4cn[nH]c4)c3n2.Cl.Cl.Cl",
    "HIT":0.0,
    "question":"Does NS(=O)(=O)c1cncc(c1)c2ccc3nccc(c4cn[nH]c4)c3n2.Cl.Cl.Cl demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":75522
  },
  {
    "COADD_ID":"CO-ADD:0260134",
    "INHIB_AVE":16.5,
    "SMILES":"c1(ccc(C)o1)C(=O)Nc2ccccc2OCC",
    "HIT":0.0,
    "question":"Does the proposed molecule c1(ccc(C)o1)C(=O)Nc2ccccc2OCC exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":5810
  },
  {
    "COADD_ID":"CO-ADD:0249921",
    "INHIB_AVE":8.72,
    "SMILES":"n12c(S\\C(=C\\c(cc3)ccc3OC(C)=O)\\C1=O)nc(cc(C)c(C)c4)c24",
    "HIT":0.0,
    "question":"Does n12c(S\\C(=C\\c(cc3)ccc3OC(C)=O)\\C1=O)nc(cc(C)c(C)c4)c24 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":20782
  },
  {
    "COADD_ID":"CO-ADD:0293740",
    "INHIB_AVE":-6.19,
    "SMILES":"n(CC(=O)Nc(c1)cc(cc1C)C)(c2c(c3C=O)cccc2)c3C",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound n(CC(=O)Nc(c1)cc(cc1C)C)(c2c(c3C=O)cccc2)c3C?",
    "answer":"No",
    "_id":74081
  },
  {
    "COADD_ID":"CO-ADD:0228394",
    "INHIB_AVE":3.5,
    "SMILES":"n1nc([nH]n1)Cc2ccccc2OC",
    "HIT":0.0,
    "question":"Does treatment with n1nc([nH]n1)Cc2ccccc2OC result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":42373
  },
  {
    "COADD_ID":"CO-ADD:0278525",
    "INHIB_AVE":-14.68,
    "SMILES":"c1(c2c(sc1NC(=O)c3ccccc3F)CCCC2)C(=O)N(CC4)CCN4C",
    "HIT":0.0,
    "question":"Does the proposed molecule c1(c2c(sc1NC(=O)c3ccccc3F)CCCC2)C(=O)N(CC4)CCN4C exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":81198
  },
  {
    "COADD_ID":"CO-ADD:0301715",
    "INHIB_AVE":-1.66,
    "SMILES":"N1(c2ccc(cc2)C)C(=O)NC(\\C(=C\\c(ccc(c3OC)OCCBr)c3)\\C1=O)=O",
    "HIT":0.0,
    "question":"Does treatment with N1(c2ccc(cc2)C)C(=O)NC(\\C(=C\\c(ccc(c3OC)OCCBr)c3)\\C1=O)=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":63298
  },
  {
    "COADD_ID":"CO-ADD:0220001",
    "INHIB_AVE":16.98,
    "SMILES":"C(O\\N=C\\c(cc1)ccc1OC)(=O)Nc(cc2)ccc2Cl",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C(O\\N=C\\c(cc1)ccc1OC)(=O)Nc(cc2)ccc2Cl?",
    "answer":"No",
    "_id":5306
  },
  {
    "COADD_ID":"CO-ADD:0159926",
    "INHIB_AVE":3.62,
    "SMILES":"[O-][N+](C1=CC=CC=C1\/C=N\/C2=CC(N=C(C3=CC=CC(C)=C3)O4)=C4C=C2)=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound [O-][N+](C1=CC=CC=C1\/C=N\/C2=CC(N=C(C3=CC=CC(C)=C3)O4)=C4C=C2)=O?",
    "answer":"No",
    "_id":41871
  },
  {
    "COADD_ID":"CO-ADD:0225755",
    "INHIB_AVE":18.77,
    "SMILES":"C1(=N2)N(C=CN=C1SCc(cc3)ccc3Cl)C(N2CC(=O)Nc4cccc(CC)c4)=O",
    "HIT":0.0,
    "question":"Does C1(=N2)N(C=CN=C1SCc(cc3)ccc3Cl)C(N2CC(=O)Nc4cccc(CC)c4)=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":3701
  },
  {
    "COADD_ID":"CO-ADD:0153091",
    "INHIB_AVE":4.94,
    "SMILES":"CN1C=C(NC(C2=CC(NC(C3=NC=C(C=CC=C4)C4=C3)=O)=CN2C)=O)C=C1C(NC5=NC(C(NCCN6CCOCC6)=O)=C(C(C)C)S5)=O.OC(C(F)(F)F)=O",
    "HIT":0.0,
    "question":"Does the proposed molecule CN1C=C(NC(C2=CC(NC(C3=NC=C(C=CC=C4)C4=C3)=O)=CN2C)=O)C=C1C(NC5=NC(C(NCCN6CCOCC6)=O)=C(C(C)C)S5)=O.OC(C(F)(F)F)=O exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":35907
  },
  {
    "COADD_ID":"CO-ADD:0303160",
    "INHIB_AVE":-6.87,
    "SMILES":"C(=C\\c(cc1)ccc1OCCOc(cc2)ccc2C(C)(C)C)(\/C(=O)N(C)C(N3C)=O)\\C3=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C(=C\\c(cc1)ccc1OCCOc(cc2)ccc2C(C)(C)C)(\/C(=O)N(C)C(N3C)=O)\\C3=O?",
    "answer":"No",
    "_id":75126
  },
  {
    "COADD_ID":"CO-ADD:0222331",
    "INHIB_AVE":-0.63,
    "SMILES":"n1c2c(oc1c3ccc(cc3)Br)ccc(c2)\\N=C\\c4cccc(I)c4O",
    "HIT":0.0,
    "question":"Does treatment with n1c2c(oc1c3ccc(cc3)Br)ccc(c2)\\N=C\\c4cccc(I)c4O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":59857
  },
  {
    "COADD_ID":"CO-ADD:0319038",
    "INHIB_AVE":12.56,
    "SMILES":"N1(CC(=O)Nc2ccc(cc2C)Br)C(=O)c(c3C1=O)cccc3",
    "HIT":0.0,
    "question":"Can N1(CC(=O)Nc2ccc(cc2C)Br)C(=O)c(c3C1=O)cccc3 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":11361
  },
  {
    "COADD_ID":"CO-ADD:0137568",
    "INHIB_AVE":-15.51,
    "SMILES":"CC(C)CCC1=C(C(NCCCN(C)C)=O)N=C(NC(C2=CC(NC(C3=CC(NC(C)=O)=CN3C)=O)=CN2C)=O)S1",
    "HIT":0.0,
    "question":"Does treatment with CC(C)CCC1=C(C(NCCCN(C)C)=O)N=C(NC(C2=CC(NC(C3=CC(NC(C)=O)=CN3C)=O)=CN2C)=O)S1 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":81442
  },
  {
    "COADD_ID":"CO-ADD:0136534",
    "INHIB_AVE":6.5,
    "SMILES":"C1CCC=C(OP(c2ccccc2)(c3ccccc3)=O)C1",
    "HIT":0.0,
    "question":"Can exposure to C1CCC=C(OP(c2ccccc2)(c3ccccc3)=O)C1 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":29122
  },
  {
    "COADD_ID":"CO-ADD:0278546",
    "INHIB_AVE":7.77,
    "SMILES":"c1(NC(CSc2nnc(SCC(=O)Nc3sc(c4c3C(OCC)=O)CCCC4)s2)=O)sc(c5c1C(OCC)=O)CCCC5",
    "HIT":0.0,
    "question":"Is c1(NC(CSc2nnc(SCC(=O)Nc3sc(c4c3C(OCC)=O)CCCC4)s2)=O)sc(c5c1C(OCC)=O)CCCC5 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":24088
  },
  {
    "COADD_ID":"CO-ADD:0227750",
    "INHIB_AVE":1.41,
    "SMILES":"N1(c(cc(cc2C(O)=O)C(O)=O)c2)C(=O)c3c(c(ccc4[N+](=O)[O-])C1=O)c4ccc3",
    "HIT":0.0,
    "question":"Is N1(c(cc(cc2C(O)=O)C(O)=O)c2)C(=O)c3c(c(ccc4[N+](=O)[O-])C1=O)c4ccc3 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":51663
  },
  {
    "COADD_ID":"CO-ADD:0250683",
    "INHIB_AVE":5.83,
    "SMILES":"C(C)(NC(=O)Nc1ccccc1Br)(C(F)(F)F)C(F)(F)F",
    "HIT":0.0,
    "question":"Does the proposed molecule C(C)(NC(=O)Nc1ccccc1Br)(C(F)(F)F)C(F)(F)F exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":31940
  },
  {
    "COADD_ID":"CO-ADD:0329167",
    "INHIB_AVE":6.68,
    "SMILES":"C(C(O)=O)(=CN1CC)C(=O)c(c12)cnc(N(CC3)CCN3C(=S)Nc(c(Cl)ccc4C(F)(F)F)c4)n2",
    "HIT":0.0,
    "question":"Is C(C(O)=O)(=CN1CC)C(=O)c(c12)cnc(N(CC3)CCN3C(=S)Nc(c(Cl)ccc4C(F)(F)F)c4)n2 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":28374
  },
  {
    "COADD_ID":"CO-ADD:0247611",
    "INHIB_AVE":-9.45,
    "SMILES":"N1(c2ccc(cc2)F)C(c3ccc(cc3)OCc4ccccc4Cl)Nc(c5C1=O)cccc5",
    "HIT":0.0,
    "question":"Can N1(c2ccc(cc2)F)C(c3ccc(cc3)OCc4ccccc4Cl)Nc(c5C1=O)cccc5 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":78273
  },
  {
    "COADD_ID":"CO-ADD:0331570",
    "INHIB_AVE":4.22,
    "SMILES":"N1(CCNC1=O)C(=O)Cc(cc2)ccc2OC",
    "HIT":0.0,
    "question":"Does the proposed molecule N1(CCNC1=O)C(=O)Cc(cc2)ccc2OC exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":39167
  },
  {
    "COADD_ID":"CO-ADD:0301679",
    "INHIB_AVE":0.05,
    "SMILES":"N(CC1C)(CC(O1)C)C(=O)c2ccccc2NC(=O)c3ccc(cc3)C",
    "HIT":0.0,
    "question":"Can N(CC1C)(CC(O1)C)C(=O)c2ccccc2NC(=O)c3ccc(cc3)C effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":57275
  },
  {
    "COADD_ID":"CO-ADD:0284203",
    "INHIB_AVE":2.54,
    "SMILES":"N1(C\\C(\\C)=N\\NC(=O)C(CC2)CCN2S(c3ccccc3)(=O)=O)C(=O)c4c(cccc4)C1=O",
    "HIT":0.0,
    "question":"Can N1(C\\C(\\C)=N\\NC(=O)C(CC2)CCN2S(c3ccccc3)(=O)=O)C(=O)c4c(cccc4)C1=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":46698
  },
  {
    "COADD_ID":"CO-ADD:0286605",
    "INHIB_AVE":-4.53,
    "SMILES":"C1(C(=O)NNC(=O)c2cccc(I)c2)=Cc3c(OC1=O)cccc3",
    "HIT":0.0,
    "question":"Does C1(C(=O)NNC(=O)c2cccc(I)c2)=Cc3c(OC1=O)cccc3 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":70901
  },
  {
    "COADD_ID":"CO-ADD:0320990",
    "INHIB_AVE":12.49,
    "SMILES":"n1(c2ccccc2)nnnc1SCC(=O)c3cccc(cccc4)c34",
    "HIT":0.0,
    "question":"Does n1(c2ccccc2)nnnc1SCC(=O)c3cccc(cccc4)c34 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":11480
  },
  {
    "COADD_ID":"CO-ADD:0220300",
    "INHIB_AVE":11.66,
    "SMILES":"n1c2c(oc1c3cccc(c3)\\N=C\\c4cc(C)cc(I)c4O)ccc(C)c2",
    "HIT":0.0,
    "question":"Is n1c2c(oc1c3cccc(c3)\\N=C\\c4cc(C)cc(I)c4O)ccc(C)c2 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":13138
  },
  {
    "COADD_ID":"CO-ADD:0149281",
    "INHIB_AVE":-5.49,
    "SMILES":"c1(c2ccccc2OC)nc(s3)c(c(N)c3C(c(cc(OCO4)c45)cc5)=O)cc1",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(c2ccccc2OC)nc(s3)c(c(N)c3C(c(cc(OCO4)c45)cc5)=O)cc1?",
    "answer":"No",
    "_id":72817
  },
  {
    "COADD_ID":"CO-ADD:0304306",
    "INHIB_AVE":-6.6,
    "SMILES":"N12C(S\\C(=C\/c3ccccc3O)\\C1=O)=NCN(c4ccc(cc4)OCC)C2",
    "HIT":0.0,
    "question":"Can N12C(S\\C(=C\/c3ccccc3O)\\C1=O)=NCN(c4ccc(cc4)OCC)C2 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":74729
  },
  {
    "COADD_ID":"CO-ADD:0283874",
    "INHIB_AVE":4.56,
    "SMILES":"C12=C(CC(c3ccccc3)CC1=O)NC(=C(C#N)C2c4cccc(OC)c4OC)C",
    "HIT":0.0,
    "question":"Can exposure to C12=C(CC(c3ccccc3)CC1=O)NC(=C(C#N)C2c4cccc(OC)c4OC)C lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":37642
  },
  {
    "COADD_ID":"CO-ADD:0158332",
    "INHIB_AVE":7.03,
    "SMILES":"O=C(N\/N=C\/C1=C(OCC)C=CC(Br)=C1)C2=CC(I)=CC=C2",
    "HIT":0.0,
    "question":"Does O=C(N\/N=C\/C1=C(OCC)C=CC(Br)=C1)C2=CC(I)=CC=C2 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":26866
  },
  {
    "COADD_ID":"CO-ADD:0242355",
    "INHIB_AVE":-7.94,
    "SMILES":"c1(C#N)c(c2ccc(cc2)Cl)cc(nc1SCc3cccc(OC)c3)c4cccs4",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(C#N)c(c2ccc(cc2)Cl)cc(nc1SCc3cccc(OC)c3)c4cccs4?",
    "answer":"No",
    "_id":76636
  },
  {
    "COADD_ID":"CO-ADD:0284351",
    "INHIB_AVE":0.9,
    "SMILES":"n1(C)c2c(nc1c3ccco3)c4c(cccc4)c(cccc5)c25",
    "HIT":0.0,
    "question":"Does n1(C)c2c(nc1c3ccco3)c4c(cccc4)c(cccc5)c25 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":53856
  },
  {
    "COADD_ID":"CO-ADD:0306104",
    "INHIB_AVE":-0.07,
    "SMILES":"C(=O)(c1cccc(F)c1)N(CC2)CCN2c3ccc(cc3F)C(C)=O",
    "HIT":0.0,
    "question":"Does treatment with C(=O)(c1cccc(F)c1)N(CC2)CCN2c3ccc(cc3F)C(C)=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":57732
  },
  {
    "COADD_ID":"CO-ADD:0149482",
    "INHIB_AVE":-2.43,
    "SMILES":"c(c(OC)c1OC)c(c2onc(NC(=O)C)c2c(cc3)ccc3OC)cc1OC",
    "HIT":0.0,
    "question":"Is c(c(OC)c1OC)c(c2onc(NC(=O)C)c2c(cc3)ccc3OC)cc1OC effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":65645
  },
  {
    "COADD_ID":"CO-ADD:0250614",
    "INHIB_AVE":4.73,
    "SMILES":"N1(c2ccc(cc2)OC)C(=O)\\C(\\SC1=S)=C\/c3c4c([nH]c3C)cccc4",
    "HIT":0.0,
    "question":"Does N1(c2ccc(cc2)OC)C(=O)\\C(\\SC1=S)=C\/c3c4c([nH]c3C)cccc4 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":36866
  },
  {
    "COADD_ID":"CO-ADD:0236148",
    "INHIB_AVE":-3.67,
    "SMILES":"C(C#N)(C1c(cccn2)c2)=C(N)N(C(CCCC3=O)=C13)c(cc4)ccc4[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C(C#N)(C1c(cccn2)c2)=C(N)N(C(CCCC3=O)=C13)c(cc4)ccc4[N+](=O)[O-]?",
    "answer":"No",
    "_id":68957
  },
  {
    "COADD_ID":"CO-ADD:0284449",
    "INHIB_AVE":-4.49,
    "SMILES":"c1(NCc2nc(c3n2Cc4ccccc4)cccc3)nc(c5n1CCN6CCCCC6)cccc5",
    "HIT":0.0,
    "question":"Does the proposed molecule c1(NCc2nc(c3n2Cc4ccccc4)cccc3)nc(c5n1CCN6CCCCC6)cccc5 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":70822
  },
  {
    "COADD_ID":"CO-ADD:0235118",
    "INHIB_AVE":7.8,
    "SMILES":"n1c2c(oc1c3cccc(OC)c3)ccc(c2)\\N=C\\c(c4)c(O)c(cc4[N+](=O)[O-])OC",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound n1c2c(oc1c3cccc(OC)c3)ccc(c2)\\N=C\\c(c4)c(O)c(cc4[N+](=O)[O-])OC?",
    "answer":"No",
    "_id":23940
  },
  {
    "COADD_ID":"CO-ADD:0136276",
    "INHIB_AVE":-4.59,
    "SMILES":"s1cccc1[As](O)(c(ccc2)s2)=O",
    "HIT":0.0,
    "question":"Is s1cccc1[As](O)(c(ccc2)s2)=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":71018
  },
  {
    "COADD_ID":"CO-ADD:0134091",
    "INHIB_AVE":1.3,
    "SMILES":"NC(=O)c1[nH]c([N+](=O)[O-])cn1",
    "HIT":0.0,
    "question":"Is NC(=O)c1[nH]c([N+](=O)[O-])cn1 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":52170
  },
  {
    "COADD_ID":"CO-ADD:0252430",
    "INHIB_AVE":5.69,
    "SMILES":"c1(c(ccc(c1)C(F)(F)F)N\\N=C\\c2ccccc2[N+](=O)[O-])[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Does treatment with c1(c(ccc(c1)C(F)(F)F)N\\N=C\\c2ccccc2[N+](=O)[O-])[N+](=O)[O-] result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":32589
  },
  {
    "COADD_ID":"CO-ADD:0242052",
    "INHIB_AVE":0.13,
    "SMILES":"N(C(=O)CSc1sc(c2n1)cccc2)(c3c4cccc3)c5c(S4)cccc5",
    "HIT":0.0,
    "question":"Can exposure to N(C(=O)CSc1sc(c2n1)cccc2)(c3c4cccc3)c5c(S4)cccc5 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":56951
  },
  {
    "COADD_ID":"CO-ADD:0331329",
    "INHIB_AVE":-0.34,
    "SMILES":"C1(C(F)(F)F)(NC(=O)c2cccc(OC)c2)C(=O)N(C(=O)N1)Cc3ccco3",
    "HIT":0.0,
    "question":"Can C1(C(F)(F)F)(NC(=O)c2cccc(OC)c2)C(=O)N(C(=O)N1)Cc3ccco3 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":58747
  },
  {
    "COADD_ID":"CO-ADD:0327295",
    "INHIB_AVE":-3.54,
    "SMILES":"c1(C(C)=O)cc(OC)c(cc1O)OC",
    "HIT":0.0,
    "question":"Does c1(C(C)=O)cc(OC)c(cc1O)OC show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":68633
  },
  {
    "COADD_ID":"CO-ADD:0287161",
    "INHIB_AVE":9.6,
    "SMILES":"C1(C)(C)C(C1\\C=C(\\Cl)\/Cl)C(=O)Nc(cc2)ccc2C(OC)=O",
    "HIT":0.0,
    "question":"Can C1(C)(C)C(C1\\C=C(\\Cl)\/Cl)C(=O)Nc(cc2)ccc2C(OC)=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":18145
  },
  {
    "COADD_ID":"CO-ADD:0227293",
    "INHIB_AVE":3.07,
    "SMILES":"C(CNc(ccc(c12)cccc1)c2)(=O)N\\N=C\\c3ccc(cc3OC)OC",
    "HIT":0.0,
    "question":"Can C(CNc(ccc(c12)cccc1)c2)(=O)N\\N=C\\c3ccc(cc3OC)OC effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":44294
  },
  {
    "COADD_ID":"CO-ADD:0323650",
    "INHIB_AVE":3.27,
    "SMILES":"C(CSCC(=O)Nc(cc1)ccc1CC)(=O)Nc2ccccc2",
    "HIT":0.0,
    "question":"Can exposure to C(CSCC(=O)Nc(cc1)ccc1CC)(=O)Nc2ccccc2 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":43404
  },
  {
    "COADD_ID":"CO-ADD:0225439",
    "INHIB_AVE":15.45,
    "SMILES":"C1(=N2)N(C=Cn(nc(c3ccc(c(C)c3)C)c4)c14)C(N2CC(=O)Nc5c(C)cc(cc5C)C)=O",
    "HIT":0.0,
    "question":"Does the proposed molecule C1(=N2)N(C=Cn(nc(c3ccc(c(C)c3)C)c4)c14)C(N2CC(=O)Nc5c(C)cc(cc5C)C)=O exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":7015
  },
  {
    "COADD_ID":"CO-ADD:0319084",
    "INHIB_AVE":-0.31,
    "SMILES":"c1(ccc(c(OC)c1OC)OC)C(=O)Nc(cc2)ccc2c(cc3)ccc3[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Does treatment with c1(ccc(c(OC)c1OC)OC)C(=O)Nc(cc2)ccc2c(cc3)ccc3[N+](=O)[O-] result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":58657
  },
  {
    "COADD_ID":"CO-ADD:0293227",
    "INHIB_AVE":9.54,
    "SMILES":"n(c(cccc1)c12)c(c3ccccc3)c(n2)c(cc4)ccc4C(=O)c5ccc(cc5)F",
    "HIT":0.0,
    "question":"Can exposure to n(c(cccc1)c12)c(c3ccccc3)c(n2)c(cc4)ccc4C(=O)c5ccc(cc5)F lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":18297
  },
  {
    "COADD_ID":"CO-ADD:0319048",
    "INHIB_AVE":17.91,
    "SMILES":"C(c1ccccc1)(=O)N(CC2)CCN2c3ccc(cc3F)C(CCC)=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C(c1ccccc1)(=O)N(CC2)CCN2c3ccc(cc3F)C(CCC)=O?",
    "answer":"No",
    "_id":4379
  },
  {
    "COADD_ID":"CO-ADD:0137606",
    "INHIB_AVE":79.13,
    "SMILES":"CN1C=C(NC(C(C=C2)=CC=C2\/C=C\/C3=CC(C=CC=C4)=C4N=C3)=O)C=C1C(NC5=CN(C)C(C(NCC[N+]6([O-])CCCCC6)=O)=C5)=O.OC(C(F)(F)F)=O",
    "HIT":1.0,
    "question":"Does treatment with CN1C=C(NC(C(C=C2)=CC=C2\/C=C\/C3=CC(C=CC=C4)=C4N=C3)=O)C=C1C(NC5=CN(C)C(C(NCC[N+]6([O-])CCCCC6)=O)=C5)=O.OC(C(F)(F)F)=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"Yes",
    "_id":158
  },
  {
    "COADD_ID":"CO-ADD:0222436",
    "INHIB_AVE":11.6,
    "SMILES":"C(=O)(Oc(cc1)ccc1\\C=N\\NC(=O)c(ccc(n2)C)c2)c3cccc(Br)c3",
    "HIT":0.0,
    "question":"Is C(=O)(Oc(cc1)ccc1\\C=N\\NC(=O)c(ccc(n2)C)c2)c3cccc(Br)c3 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":13241
  },
  {
    "COADD_ID":"CO-ADD:0232714",
    "INHIB_AVE":-17.86,
    "SMILES":"c1(\\C(\\CCC2)=N\\N=C\/c(cc3)ccc3[N+](=O)[O-])c2c4c(ccc(C5CCCCC5)c4)[nH]1",
    "HIT":0.0,
    "question":"Does c1(\\C(\\CCC2)=N\\N=C\/c(cc3)ccc3[N+](=O)[O-])c2c4c(ccc(C5CCCCC5)c4)[nH]1 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":81886
  },
  {
    "COADD_ID":"CO-ADD:0244924",
    "INHIB_AVE":0.09,
    "SMILES":"C(N(C)C1=S)C(C(=O)N2)(C(=O)NC2=O)CN1C",
    "HIT":0.0,
    "question":"Does C(N(C)C1=S)C(C(=O)N2)(C(=O)NC2=O)CN1C show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":57111
  },
  {
    "COADD_ID":"CO-ADD:0291532",
    "INHIB_AVE":5.97,
    "SMILES":"c(Sc1nccn1C)(n2)nc(nc2Nc(cc3)ccc3OC)Nc(cc4)ccc4OC",
    "HIT":0.0,
    "question":"Can exposure to c(Sc1nccn1C)(n2)nc(nc2Nc(cc3)ccc3OC)Nc(cc4)ccc4OC lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":31383
  },
  {
    "COADD_ID":"CO-ADD:0252768",
    "INHIB_AVE":2.69,
    "SMILES":"n1(c2cccc(cccc3)c23)nnnc1N\\N=C\\c(cccc4[N+](=O)[O-])c4",
    "HIT":0.0,
    "question":"Does n1(c2cccc(cccc3)c23)nnnc1N\\N=C\\c(cccc4[N+](=O)[O-])c4 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":45994
  },
  {
    "COADD_ID":"CO-ADD:0256396",
    "INHIB_AVE":-4.03,
    "SMILES":"S(=O)(=O)(c1ccc(cc1)OCC)N(c2ccc(cc2)C)CC(NCCOC)=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound S(=O)(=O)(c1ccc(cc1)OCC)N(c2ccc(cc2)C)CC(NCCOC)=O?",
    "answer":"No",
    "_id":69832
  },
  {
    "COADD_ID":"CO-ADD:0229684",
    "INHIB_AVE":15.66,
    "SMILES":"c1(NCC(=O)N\\N=C\\c(cc2)ccc2N(CC)CC)c(Br)cc(cc1Br)Cl",
    "HIT":0.0,
    "question":"Can c1(NCC(=O)N\\N=C\\c(cc2)ccc2N(CC)CC)c(Br)cc(cc1Br)Cl effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":6760
  },
  {
    "COADD_ID":"CO-ADD:0328770",
    "INHIB_AVE":-1.16,
    "SMILES":"c12c(ccc(OC)c1I)C(C)=C(C(=O)O2)C",
    "HIT":0.0,
    "question":"Can c12c(ccc(OC)c1I)C(C)=C(C(=O)O2)C effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":61636
  },
  {
    "COADD_ID":"CO-ADD:0242185",
    "INHIB_AVE":0.14,
    "SMILES":"[C@H]1(\\C(=N\\NC(=O)c(c2)cc(cc2[N+](=O)[O-])[N+](=O)[O-])\\[C@H]3O[C@@H]4CO3)[C@@H]4C1C(=O)c5cccs5",
    "HIT":0.0,
    "question":"Can [C@H]1(\\C(=N\\NC(=O)c(c2)cc(cc2[N+](=O)[O-])[N+](=O)[O-])\\[C@H]3O[C@@H]4CO3)[C@@H]4C1C(=O)c5cccs5 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":56923
  },
  {
    "COADD_ID":"CO-ADD:0326725",
    "INHIB_AVE":-3.39,
    "SMILES":"n1(c2c(s3)cccc2)c3nnc1SCC(=O)Nc4c(OC)ccc(OC)c4",
    "HIT":0.0,
    "question":"Does n1(c2c(s3)cccc2)c3nnc1SCC(=O)Nc4c(OC)ccc(OC)c4 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":68245
  },
  {
    "COADD_ID":"CO-ADD:0136375",
    "INHIB_AVE":-6.91,
    "SMILES":"[H]n1c(c(cccc2)c2)cc(C#N)c1c3c(ccc4)c(ccn3)c4",
    "HIT":0.0,
    "question":"Can [H]n1c(c(cccc2)c2)cc(C#N)c1c3c(ccc4)c(ccn3)c4 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":75196
  },
  {
    "COADD_ID":"CO-ADD:0221111",
    "INHIB_AVE":-7.36,
    "SMILES":"[C@@]1(C#N)(C#N)[C@@H]([C@H]1c2ccccc2Cl)C(N)=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound [C@@]1(C#N)(C#N)[C@@H]([C@H]1c2ccccc2Cl)C(N)=O?",
    "answer":"No",
    "_id":75872
  },
  {
    "COADD_ID":"CO-ADD:0328867",
    "INHIB_AVE":2.11,
    "SMILES":"n(c1c2cccn1)c(\\C=C(\\C)\/O)c(n2)\\C=C(\\C)\/O",
    "HIT":0.0,
    "question":"Can exposure to n(c1c2cccn1)c(\\C=C(\\C)\/O)c(n2)\\C=C(\\C)\/O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":48554
  },
  {
    "COADD_ID":"CO-ADD:0291811",
    "INHIB_AVE":9.48,
    "SMILES":"N1(NC(=O)c2ccccc2[N+](=O)[O-])C(=S)S\\C(\\C1=O)=C(\\c3c(N4)ccc(Br)c3)\/C4=O",
    "HIT":0.0,
    "question":"Is N1(NC(=O)c2ccccc2[N+](=O)[O-])C(=S)S\\C(\\C1=O)=C(\\c3c(N4)ccc(Br)c3)\/C4=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":18493
  },
  {
    "COADD_ID":"CO-ADD:0331788",
    "INHIB_AVE":15.54,
    "SMILES":"C1(=COc(c2C1=O)ccc(C)c2)C3C4=C(CC(c5cccs5)CC4=O)NC(C)=C3C(=O)OCC(C)C",
    "HIT":0.0,
    "question":"Is C1(=COc(c2C1=O)ccc(C)c2)C3C4=C(CC(c5cccs5)CC4=O)NC(C)=C3C(=O)OCC(C)C effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":6891
  },
  {
    "COADD_ID":"CO-ADD:0162267",
    "INHIB_AVE":8.06,
    "SMILES":"c1(N(CC2)CCO2)nc(N\\N=C\/c(cc(I)cc3I)c3O)nc(Nc4cccc(Br)c4)n1",
    "HIT":0.0,
    "question":"Can c1(N(CC2)CCO2)nc(N\\N=C\/c(cc(I)cc3I)c3O)nc(Nc4cccc(Br)c4)n1 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":22984
  },
  {
    "COADD_ID":"CO-ADD:0218002",
    "INHIB_AVE":7.18,
    "SMILES":"c1(Nc2c(Cl)ccc(Cl)c2)c(c(C)nc(Nc3c(Cl)ccc(Cl)c3)n1)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Is c1(Nc2c(Cl)ccc(Cl)c2)c(c(C)nc(Nc3c(Cl)ccc(Cl)c3)n1)[N+](=O)[O-] capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":26286
  },
  {
    "COADD_ID":"CO-ADD:0302690",
    "INHIB_AVE":4.37,
    "SMILES":"N(C(=O)\\C(\\S1)=C\\c2ccccc2)=C1N(CC3)CCN3C(c4ccccc4)c5ccccc5",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound N(C(=O)\\C(\\S1)=C\\c2ccccc2)=C1N(CC3)CCN3C(c4ccccc4)c5ccccc5?",
    "answer":"No",
    "_id":38480
  },
  {
    "COADD_ID":"CO-ADD:0235360",
    "INHIB_AVE":3.72,
    "SMILES":"N1(NC(=O)c2ccc(cc2)Br)C(=O)C3C(C(C4(CC4)C35)C=C5)C1=O",
    "HIT":0.0,
    "question":"Does the proposed molecule N1(NC(=O)c2ccc(cc2)Br)C(=O)C3C(C(C4(CC4)C35)C=C5)C1=O exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":41415
  },
  {
    "COADD_ID":"CO-ADD:0292039",
    "INHIB_AVE":-0.12,
    "SMILES":"s1c(c2ccc(cc2)Br)nnc1NC(=O)c3ccc(cc3)F",
    "HIT":0.0,
    "question":"Is s1c(c2ccc(cc2)Br)nnc1NC(=O)c3ccc(cc3)F effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":57947
  },
  {
    "COADD_ID":"CO-ADD:0324634",
    "INHIB_AVE":12.06,
    "SMILES":"C1(CC(OC12CCCCC2)=O)C(=O)N([H])c3ccccc3OC",
    "HIT":0.0,
    "question":"Can C1(CC(OC12CCCCC2)=O)C(=O)N([H])c3ccccc3OC effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":12340
  },
  {
    "COADD_ID":"CO-ADD:0234086",
    "INHIB_AVE":-3.68,
    "SMILES":"C(=O)(Nc(cc1)ccc1C)CC(NN)=O",
    "HIT":0.0,
    "question":"Does C(=O)(Nc(cc1)ccc1C)CC(NN)=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":68997
  },
  {
    "COADD_ID":"CO-ADD:0258936",
    "INHIB_AVE":5.74,
    "SMILES":"N1(c2cccc(C)c2C)C(CSc3sc(c4n3)cccc4)=Nc(c5C1=O)cccc5",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound N1(c2cccc(C)c2C)C(CSc3sc(c4n3)cccc4)=Nc(c5C1=O)cccc5?",
    "answer":"No",
    "_id":32390
  },
  {
    "COADD_ID":"CO-ADD:0326475",
    "INHIB_AVE":6.63,
    "SMILES":"c12c(ccc(c1)NC(C)=O)C(C)=CC(=O)N2[H]",
    "HIT":0.0,
    "question":"Can c12c(ccc(c1)NC(C)=O)C(C)=CC(=O)N2[H] effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":28578
  },
  {
    "COADD_ID":"CO-ADD:0245848",
    "INHIB_AVE":22.91,
    "SMILES":"c1(Cl)cc(Cl)ccc1\\C=N\\NC(CCC(=O)NC2CCCCC2)=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(Cl)cc(Cl)ccc1\\C=N\\NC(CCC(=O)NC2CCCCC2)=O?",
    "answer":"No",
    "_id":1646
  },
  {
    "COADD_ID":"CO-ADD:0319585",
    "INHIB_AVE":-3.31,
    "SMILES":"c1(c2ccc(cc2)OCCC)cc(c(cccn3)c3)nc(ccc(cccc4)c45)c15",
    "HIT":0.0,
    "question":"Can c1(c2ccc(cc2)OCCC)cc(c(cccn3)c3)nc(ccc(cccc4)c45)c15 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":68042
  },
  {
    "COADD_ID":"CO-ADD:0164474",
    "INHIB_AVE":92.69,
    "SMILES":"CN(C)[C@H]1[C@@H]2[C@@H](O)[C@H]3C(=C(O)[C@]2(O)C(O)=C(C(N)=O)C1=O)C(=O)c1c(O)cccc1[C@@]3(C)O.Cl",
    "HIT":1.0,
    "question":"Can CN(C)[C@H]1[C@@H]2[C@@H](O)[C@H]3C(=C(O)[C@]2(O)C(O)=C(C(N)=O)C1=O)C(=O)c1c(O)cccc1[C@@]3(C)O.Cl act as an antibacterial agent targeting Escherichia coli?",
    "answer":"Yes",
    "_id":51
  },
  {
    "COADD_ID":"CO-ADD:0158601",
    "INHIB_AVE":6.22,
    "SMILES":"O=S(C1=C(Cl)C=CC(C(NC2=CC=CC=C2OC)=O)=C1)(N3CCOCC3)=O",
    "HIT":0.0,
    "question":"Is O=S(C1=C(Cl)C=CC(C(NC2=CC=CC=C2OC)=O)=C1)(N3CCOCC3)=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":30322
  },
  {
    "COADD_ID":"CO-ADD:0236357",
    "INHIB_AVE":5.0,
    "SMILES":"n12c(ccc(N\\N=C\\c3ccc(cc3OC)OC)n1)nnc2C(F)(F)F",
    "HIT":0.0,
    "question":"Can n12c(ccc(N\\N=C\\c3ccc(cc3OC)OC)n1)nnc2C(F)(F)F act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":35641
  },
  {
    "COADD_ID":"CO-ADD:0304729",
    "INHIB_AVE":12.87,
    "SMILES":"C(=O)(Oc1cc(ccc1OC)C=O)N(CC2)CCO2",
    "HIT":0.0,
    "question":"Can C(=O)(Oc1cc(ccc1OC)C=O)N(CC2)CCO2 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":10813
  },
  {
    "COADD_ID":"CO-ADD:0230319",
    "INHIB_AVE":15.08,
    "SMILES":"C(c1ccccc1)(=O)Nc2cccc(C)c2",
    "HIT":0.0,
    "question":"Does the proposed molecule C(c1ccccc1)(=O)Nc2cccc(C)c2 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":7502
  },
  {
    "COADD_ID":"CO-ADD:0220080",
    "INHIB_AVE":-0.57,
    "SMILES":"c1(NC(=O)C(Cl)(Cl)Cl)sc(c(C)c1C(OCC)=O)C(OCC)=O",
    "HIT":0.0,
    "question":"Is c1(NC(=O)C(Cl)(Cl)Cl)sc(c(C)c1C(OCC)=O)C(OCC)=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":59614
  },
  {
    "COADD_ID":"CO-ADD:0219204",
    "INHIB_AVE":7.47,
    "SMILES":"[N+](=O)([O-])c1ccccc1COc2ccccc2\\C=N\\NC(=O)c3ccc(cc3)OCCCCCCCCCC",
    "HIT":0.0,
    "question":"Is [N+](=O)([O-])c1ccccc1COc2ccccc2\\C=N\\NC(=O)c3ccc(cc3)OCCCCCCCCCC capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":25167
  },
  {
    "COADD_ID":"CO-ADD:0300069",
    "INHIB_AVE":0.68,
    "SMILES":"N1(c2cccc(C)c2)C(=O)NC(\\C(=C\\c(cc(OCO3)c3c4)c4Cl)\\C1=O)=O",
    "HIT":0.0,
    "question":"Does N1(c2cccc(C)c2)C(=O)NC(\\C(=C\\c(cc(OCO3)c3c4)c4Cl)\\C1=O)=O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":54811
  },
  {
    "COADD_ID":"CO-ADD:0255621",
    "INHIB_AVE":-14.3,
    "SMILES":"N1(C(C)CC(c(cccc2)c12)Nc3ccccc3)C(=O)c4cccc(OC)c4",
    "HIT":0.0,
    "question":"Is N1(C(C)CC(c(cccc2)c12)Nc3ccccc3)C(=O)c4cccc(OC)c4 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":81079
  },
  {
    "COADD_ID":"CO-ADD:0258656",
    "INHIB_AVE":16.9,
    "SMILES":"c(C(=O)c1ccc(cc1)Cl)(sc(c23)nc(c(C)c2C)C)c3N",
    "HIT":0.0,
    "question":"Is c(C(=O)c1ccc(cc1)Cl)(sc(c23)nc(c(C)c2C)C)c3N capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":5376
  },
  {
    "COADD_ID":"CO-ADD:0259828",
    "INHIB_AVE":-2.8,
    "SMILES":"C1(C(=O)OC2CCCCCC2)=C(C)NC(NC1c3cccc(c3)OCc4ccccc4)=O",
    "HIT":0.0,
    "question":"Is C1(C(=O)OC2CCCCCC2)=C(C)NC(NC1c3cccc(c3)OCc4ccccc4)=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":66688
  },
  {
    "COADD_ID":"CO-ADD:0331944",
    "INHIB_AVE":7.04,
    "SMILES":"S(=O)(=O)(c(cc1)ccc1C2CCCCC2)N(CC3)CCN3c4cccc(Cl)c4",
    "HIT":0.0,
    "question":"Can exposure to S(=O)(=O)(c(cc1)ccc1C2CCCCC2)N(CC3)CCN3c4cccc(Cl)c4 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":26806
  },
  {
    "COADD_ID":"CO-ADD:0291516",
    "INHIB_AVE":-2.94,
    "SMILES":"c1(c(ccc(c2NC(=O)c3cc(c4o3)cccc4)Cl)c2)oc(c5n1)cccc5",
    "HIT":0.0,
    "question":"Can exposure to c1(c(ccc(c2NC(=O)c3cc(c4o3)cccc4)Cl)c2)oc(c5n1)cccc5 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":67091
  },
  {
    "COADD_ID":"CO-ADD:0299507",
    "INHIB_AVE":-10.21,
    "SMILES":"C(C)(=O)NNc(cc1)ccc1C",
    "HIT":0.0,
    "question":"Does C(C)(=O)NNc(cc1)ccc1C demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":78844
  },
  {
    "COADD_ID":"CO-ADD:0247928",
    "INHIB_AVE":9.95,
    "SMILES":"N1(C2c3ccccc3)C(S\\C(=C\\c4cc(I)cc(I)c4O)\\C1=O)=NC(C)=C2C(OCC)=O",
    "HIT":0.0,
    "question":"Does N1(C2c3ccccc3)C(S\\C(=C\\c4cc(I)cc(I)c4O)\\C1=O)=NC(C)=C2C(OCC)=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":17137
  },
  {
    "COADD_ID":"CO-ADD:0305875",
    "INHIB_AVE":6.8,
    "SMILES":"c([N+](=O)[O-])(nn(c1C(=O)Nc2sc(c3c2C(OCC)=O)CCCCC3)Cc4ccccc4)c1",
    "HIT":0.0,
    "question":"Is c([N+](=O)[O-])(nn(c1C(=O)Nc2sc(c3c2C(OCC)=O)CCCCC3)Cc4ccccc4)c1 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":27794
  },
  {
    "COADD_ID":"CO-ADD:0222418",
    "INHIB_AVE":-7.31,
    "SMILES":"c(Nc1ccccc1)(nc(N\\N=C\\c2ccccc2Br)nc3Nc4ccccc4)n3",
    "HIT":0.0,
    "question":"Can c(Nc1ccccc1)(nc(N\\N=C\\c2ccccc2Br)nc3Nc4ccccc4)n3 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":75781
  },
  {
    "COADD_ID":"CO-ADD:0299277",
    "INHIB_AVE":3.44,
    "SMILES":"c1(OC(N)=C(C2c3c(cccc3F)Cl)C#N)c2c(n[nH]1)CCC",
    "HIT":0.0,
    "question":"Does treatment with c1(OC(N)=C(C2c3c(cccc3F)Cl)C#N)c2c(n[nH]1)CCC result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":42646
  },
  {
    "COADD_ID":"CO-ADD:0302066",
    "INHIB_AVE":-0.07,
    "SMILES":"c1(cc(O)ccc1NC(CSCc2ccc(cc2Cl)Cl)=O)C(O)=O.Cl",
    "HIT":0.0,
    "question":"Does c1(cc(O)ccc1NC(CSCc2ccc(cc2Cl)Cl)=O)C(O)=O.Cl demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":57745
  },
  {
    "COADD_ID":"CO-ADD:0252188",
    "INHIB_AVE":-2.5,
    "SMILES":"c1([nH]c(c2n1)cccc2)\\C(\\C#N)=C\\c(cc3OC)cc(c3OCC)I",
    "HIT":0.0,
    "question":"Does c1([nH]c(c2n1)cccc2)\\C(\\C#N)=C\\c(cc3OC)cc(c3OCC)I show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":65837
  },
  {
    "COADD_ID":"CO-ADD:0166542",
    "INHIB_AVE":-0.67,
    "SMILES":"C(=O)(N\\N=C\\c1ccc(cc1Cl)Cl)C(=O)Nc2cc(C)ccc2C",
    "HIT":0.0,
    "question":"Is C(=O)(N\\N=C\\c1ccc(cc1Cl)Cl)C(=O)Nc2cc(C)ccc2C capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":60001
  },
  {
    "COADD_ID":"CO-ADD:0240766",
    "INHIB_AVE":16.28,
    "SMILES":"N1(C(c2ccc(cc2)F)CC(c(cccc3[N+](=O)[O-])c3)=N1)c4scc(c5ccc(cc5)C)n4.Br",
    "HIT":0.0,
    "question":"Can N1(C(c2ccc(cc2)F)CC(c(cccc3[N+](=O)[O-])c3)=N1)c4scc(c5ccc(cc5)C)n4.Br effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":6028
  },
  {
    "COADD_ID":"CO-ADD:0290559",
    "INHIB_AVE":-4.32,
    "SMILES":"C1(CC(C)(C)NC2=S)(CC(c3ccccc3Cl)Oc(cc(O)c(Cl)c4)c14)N2",
    "HIT":0.0,
    "question":"Does treatment with C1(CC(C)(C)NC2=S)(CC(c3ccccc3Cl)Oc(cc(O)c(Cl)c4)c14)N2 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":70452
  },
  {
    "COADD_ID":"CO-ADD:0329948",
    "INHIB_AVE":-0.25,
    "SMILES":"C12=C(CC(C)(C)CC1=O)OC(=C(CC)C2=O)CCCC",
    "HIT":0.0,
    "question":"Can C12=C(CC(C)(C)CC1=O)OC(=C(CC)C2=O)CCCC act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":58417
  },
  {
    "COADD_ID":"CO-ADD:0306732",
    "INHIB_AVE":-1.65,
    "SMILES":"N1(c2ccccc2Cl)C(c3ccc(c(cccc4[N+](=O)[O-])c4)o3)Nc(c5C1=O)cccc5",
    "HIT":0.0,
    "question":"Can N1(c2ccccc2Cl)C(c3ccc(c(cccc4[N+](=O)[O-])c4)o3)Nc(c5C1=O)cccc5 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":63264
  },
  {
    "COADD_ID":"CO-ADD:0277361",
    "INHIB_AVE":-1.3,
    "SMILES":"C(\/C#N)(=C\/c(cc1)ccc1Cl)\\C(=O)Nc(ccc(c2C)C)c2",
    "HIT":0.0,
    "question":"Does treatment with C(\/C#N)(=C\/c(cc1)ccc1Cl)\\C(=O)Nc(ccc(c2C)C)c2 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":62091
  },
  {
    "COADD_ID":"CO-ADD:0311902",
    "INHIB_AVE":2.27,
    "SMILES":"C(\/C(CCC1)=O)(\\C1=O)=C\/Nc(cc2)ccc2C(=O)NC3CCCCC3",
    "HIT":0.0,
    "question":"Does C(\/C(CCC1)=O)(\\C1=O)=C\/Nc(cc2)ccc2C(=O)NC3CCCCC3 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":47905
  },
  {
    "COADD_ID":"CO-ADD:0232843",
    "INHIB_AVE":10.24,
    "SMILES":"S1(=O)(=O)c(cccc2)c2C(Nc3ccccc3C(O)=O)=N1",
    "HIT":0.0,
    "question":"Is S1(=O)(=O)c(cccc2)c2C(Nc3ccccc3C(O)=O)=N1 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":16399
  },
  {
    "COADD_ID":"CO-ADD:0221529",
    "INHIB_AVE":7.59,
    "SMILES":"S(=O)(=O)(c1ccc(cc1)Oc(cc2)ccc2S(=O)(=O)N(C)c3ccc(cc3[N+](=O)[O-])[N+](=O)[O-])N(C)c4ccc(cc4[N+](=O)[O-])[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Does S(=O)(=O)(c1ccc(cc1)Oc(cc2)ccc2S(=O)(=O)N(C)c3ccc(cc3[N+](=O)[O-])[N+](=O)[O-])N(C)c4ccc(cc4[N+](=O)[O-])[N+](=O)[O-] show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":24733
  },
  {
    "COADD_ID":"CO-ADD:0230315",
    "INHIB_AVE":13.99,
    "SMILES":"[n+](C)(c(C)c1)cc(c1Nc2ccccc2)C.[I-]",
    "HIT":0.0,
    "question":"Does [n+](C)(c(C)c1)cc(c1Nc2ccccc2)C.[I-] show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":9052
  },
  {
    "COADD_ID":"CO-ADD:0232516",
    "INHIB_AVE":10.67,
    "SMILES":"n1c2c(oc1c3ccc(cc3)\\N=C\\c(cc(Br)cc4[N+](=O)[O-])c4O)cccn2",
    "HIT":0.0,
    "question":"Does n1c2c(oc1c3ccc(cc3)\\N=C\\c(cc(Br)cc4[N+](=O)[O-])c4O)cccn2 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":15286
  },
  {
    "COADD_ID":"CO-ADD:0232946",
    "INHIB_AVE":1.44,
    "SMILES":"N(c1ccccn1)C(COc(cc2)ccc2\\C=N\\c(cc3)ccc3Nc4ccccc4)=O",
    "HIT":0.0,
    "question":"Is N(c1ccccn1)C(COc(cc2)ccc2\\C=N\\c(cc3)ccc3Nc4ccccc4)=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":51546
  },
  {
    "COADD_ID":"CO-ADD:0250102",
    "INHIB_AVE":-3.97,
    "SMILES":"N1c(cccc2)c2C3C(CC=C3)C1c4ccc(cc4)\\N=C\\c5ccccc5O",
    "HIT":0.0,
    "question":"Is N1c(cccc2)c2C3C(CC=C3)C1c4ccc(cc4)\\N=C\\c5ccccc5O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":69691
  },
  {
    "COADD_ID":"CO-ADD:0250627",
    "INHIB_AVE":2.7,
    "SMILES":"N1(CC)C(=O)\\C(\\SC1=S)=C\/c(cc2)ccn2",
    "HIT":0.0,
    "question":"Does N1(CC)C(=O)\\C(\\SC1=S)=C\/c(cc2)ccn2 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":45983
  },
  {
    "COADD_ID":"CO-ADD:0236326",
    "INHIB_AVE":11.75,
    "SMILES":"C12=C(C(C(C#N)=C(N)O1)c3ccccc3)C(N(C)C(=O)N2C)=O",
    "HIT":0.0,
    "question":"Can exposure to C12=C(C(C(C#N)=C(N)O1)c3ccccc3)C(N(C)C(=O)N2C)=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":12924
  },
  {
    "COADD_ID":"CO-ADD:0244363",
    "INHIB_AVE":10.78,
    "SMILES":"c1(cc(ccc1N(CC2)CCN2Cc3ccccc3)[N+](=O)[O-])[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(cc(ccc1N(CC2)CCN2Cc3ccccc3)[N+](=O)[O-])[N+](=O)[O-]?",
    "answer":"No",
    "_id":15039
  },
  {
    "COADD_ID":"CO-ADD:0166516",
    "INHIB_AVE":8.16,
    "SMILES":"c1(ccc(c(cccc2)c12)F)C(NCCOc3ccccc3F)=O",
    "HIT":0.0,
    "question":"Does c1(ccc(c(cccc2)c12)F)C(NCCOc3ccccc3F)=O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":22615
  },
  {
    "COADD_ID":"CO-ADD:0303690",
    "INHIB_AVE":-6.63,
    "SMILES":"S(=O)(=O)(c1ccc(c2c1)cccc2)N3CCCC3C(NCCOc4cccc(Cl)c4Cl)=O",
    "HIT":0.0,
    "question":"Is S(=O)(=O)(c1ccc(c2c1)cccc2)N3CCCC3C(NCCOc4cccc(Cl)c4Cl)=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":74785
  },
  {
    "COADD_ID":"CO-ADD:0160188",
    "INHIB_AVE":0.21,
    "SMILES":"O=C(NC1=CC(SC2=CC=CC=C2)=CC(SC3=CC=CC=C3)=C1)C(C=CC=C4)=C4F",
    "HIT":0.0,
    "question":"Can O=C(NC1=CC(SC2=CC=CC=C2)=CC(SC3=CC=CC=C3)=C1)C(C=CC=C4)=C4F act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":56633
  },
  {
    "COADD_ID":"CO-ADD:0291434",
    "INHIB_AVE":5.93,
    "SMILES":"c1(C(OCC)=O)c(cc(OC)cc2)c2n(c3ccc(cc3)Br)c1C",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(C(OCC)=O)c(cc(OC)cc2)c2n(c3ccc(cc3)Br)c1C?",
    "answer":"No",
    "_id":31533
  },
  {
    "COADD_ID":"CO-ADD:0163338",
    "INHIB_AVE":6.99,
    "SMILES":"C(=O)(c1cccc(F)c1)NCC(=O)N\\N=C(\/C)\\c2ccccc2",
    "HIT":0.0,
    "question":"Can exposure to C(=O)(c1cccc(F)c1)NCC(=O)N\\N=C(\/C)\\c2ccccc2 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":27024
  },
  {
    "COADD_ID":"CO-ADD:0326270",
    "INHIB_AVE":5.26,
    "SMILES":"c(CN(c1ccc(cc1)F)C(=O)c2ccccc2Cl)(c(C)[nH]c3C(OCC)=O)c3C",
    "HIT":0.0,
    "question":"Does the proposed molecule c(CN(c1ccc(cc1)F)C(=O)c2ccccc2Cl)(c(C)[nH]c3C(OCC)=O)c3C exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":34505
  },
  {
    "COADD_ID":"CO-ADD:0232971",
    "INHIB_AVE":5.09,
    "SMILES":"N1(c2ccccc2c3ccccc3)C(=O)c(c4C1=O)ccc(c4)C(=O)Nc5ccccc5C(O)=O",
    "HIT":0.0,
    "question":"Can exposure to N1(c2ccccc2c3ccccc3)C(=O)c(c4C1=O)ccc(c4)C(=O)Nc5ccccc5C(O)=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":35263
  },
  {
    "COADD_ID":"CO-ADD:0165976",
    "INHIB_AVE":7.46,
    "SMILES":"[N+](=O)([O-])c1ccccc1\\C=N\\NC(=O)c2ccc(cc2)COc(cc3)ccc3C",
    "HIT":0.0,
    "question":"Can [N+](=O)([O-])c1ccccc1\\C=N\\NC(=O)c2ccc(cc2)COc(cc3)ccc3C act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":25225
  },
  {
    "COADD_ID":"CO-ADD:0148965",
    "INHIB_AVE":6.91,
    "SMILES":"c1(C(=O)c2ccc(cc2)OC)oc(c3c1N)cccc3",
    "HIT":0.0,
    "question":"Does c1(C(=O)c2ccc(cc2)OC)oc(c3c1N)cccc3 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":27355
  },
  {
    "COADD_ID":"CO-ADD:0218915",
    "INHIB_AVE":0.67,
    "SMILES":"C(OC)(=O)c1ccc(cc1)CSc2ccccc2",
    "HIT":0.0,
    "question":"Does the proposed molecule C(OC)(=O)c1ccc(cc1)CSc2ccccc2 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":54827
  },
  {
    "COADD_ID":"CO-ADD:0287207",
    "INHIB_AVE":2.42,
    "SMILES":"N1(C2c3c(OC)ccc(cccc4)c34)C(S\\C(=C\\c(ccc5c(cc6)ccc6C(OCC)=O)o5)\\C1=O)=NC(c7ccccc7)=C2C(OCC)=O",
    "HIT":0.0,
    "question":"Can N1(C2c3c(OC)ccc(cccc4)c34)C(S\\C(=C\\c(ccc5c(cc6)ccc6C(OCC)=O)o5)\\C1=O)=NC(c7ccccc7)=C2C(OCC)=O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":47222
  },
  {
    "COADD_ID":"CO-ADD:0241899",
    "INHIB_AVE":-5.47,
    "SMILES":"C1(=S)N(c2ccccc2)C(=O)\\C(\\C(=O)N1c3ccccc3)=C\/c(ccc4c5ccc(cc5)Br)o4",
    "HIT":0.0,
    "question":"Does C1(=S)N(c2ccccc2)C(=O)\\C(\\C(=O)N1c3ccccc3)=C\/c(ccc4c5ccc(cc5)Br)o4 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":72794
  },
  {
    "COADD_ID":"CO-ADD:0293664",
    "INHIB_AVE":3.37,
    "SMILES":"C12=C(CC(c3ccccc3)CC1=O)Nc(c4NC2c5cc(OC)ccc5OC)cccc4",
    "HIT":0.0,
    "question":"Can exposure to C12=C(CC(c3ccccc3)CC1=O)Nc(c4NC2c5cc(OC)ccc5OC)cccc4 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":42949
  },
  {
    "COADD_ID":"CO-ADD:0320011",
    "INHIB_AVE":5.28,
    "SMILES":"c1(C2OC(CC)(CC)c3c(cccc3)N2)c(cc(cc1[N+](=O)[O-])[N+](=O)[O-])[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Does c1(C2OC(CC)(CC)c3c(cccc3)N2)c(cc(cc1[N+](=O)[O-])[N+](=O)[O-])[N+](=O)[O-] show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":34406
  },
  {
    "COADD_ID":"CO-ADD:0231100",
    "INHIB_AVE":-7.02,
    "SMILES":"C(N(CCC)CCC)(=S)Oc(cc1)ccc1C(=O)Nc(cc2)ccc2Br",
    "HIT":0.0,
    "question":"Is C(N(CCC)CCC)(=S)Oc(cc1)ccc1C(=O)Nc(cc2)ccc2Br effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":75355
  },
  {
    "COADD_ID":"CO-ADD:0164448",
    "INHIB_AVE":2.49,
    "SMILES":"CN1CCCCC1C(=O)Nc1c(C)cccc1C.Cl",
    "HIT":0.0,
    "question":"Can CN1CCCCC1C(=O)Nc1c(C)cccc1C.Cl effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":46921
  },
  {
    "COADD_ID":"CO-ADD:0310952",
    "INHIB_AVE":2.25,
    "SMILES":"N1(c2cccc(Cl)c2)N=C(\\C(=C\/c(cc3)ccc3OCc4ccccc4F)\\C1=O)C",
    "HIT":0.0,
    "question":"Does N1(c2cccc(Cl)c2)N=C(\\C(=C\/c(cc3)ccc3OCc4ccccc4F)\\C1=O)C demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":48037
  },
  {
    "COADD_ID":"CO-ADD:0231017",
    "INHIB_AVE":11.72,
    "SMILES":"C(=O)(Nc(cc1)ccc1Br)C\\C(\\C)=N\\NC(COc2ccccc2C)=O",
    "HIT":0.0,
    "question":"Can exposure to C(=O)(Nc(cc1)ccc1Br)C\\C(\\C)=N\\NC(COc2ccccc2C)=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":13001
  },
  {
    "COADD_ID":"CO-ADD:0228572",
    "INHIB_AVE":-1.16,
    "SMILES":"N1(c2ccccc2Cl)C(=O)CC(N(CC3)CCN3Cc(ccc(c45)OCO4)c5)C1=O",
    "HIT":0.0,
    "question":"Can exposure to N1(c2ccccc2Cl)C(=O)CC(N(CC3)CCN3Cc(ccc(c45)OCO4)c5)C1=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":61614
  },
  {
    "COADD_ID":"CO-ADD:0285492",
    "INHIB_AVE":2.37,
    "SMILES":"c1(c2ccccc2)nc(oc1c3ccccc3)SCc4ccccc4C#N",
    "HIT":0.0,
    "question":"Does c1(c2ccccc2)nc(oc1c3ccccc3)SCc4ccccc4C#N demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":47430
  },
  {
    "COADD_ID":"CO-ADD:0292846",
    "INHIB_AVE":-8.4,
    "SMILES":"C(=C\\c(cc1OC)cc(c1OC)OC)(\/C2=O)\\C(c3ccccc3)=NO2",
    "HIT":0.0,
    "question":"Can C(=C\\c(cc1OC)cc(c1OC)OC)(\/C2=O)\\C(c3ccccc3)=NO2 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":77196
  },
  {
    "COADD_ID":"CO-ADD:0163216",
    "INHIB_AVE":15.62,
    "SMILES":"c(ccc(n1)C)(c1)C(=O)N\\N=C\\c(cc2)cc(c2OC(C)=O)OC",
    "HIT":0.0,
    "question":"Does c(ccc(n1)C)(c1)C(=O)N\\N=C\\c(cc2)cc(c2OC(C)=O)OC demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":6796
  },
  {
    "COADD_ID":"CO-ADD:0240326",
    "INHIB_AVE":0.15,
    "SMILES":"S(=O)(=O)(c1ccc(cc1)C)N(c2ccccc2C)CC(=O)N3CCCCC3",
    "HIT":0.0,
    "question":"Can S(=O)(=O)(c1ccc(cc1)C)N(c2ccccc2C)CC(=O)N3CCCCC3 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":56882
  },
  {
    "COADD_ID":"CO-ADD:0218618",
    "INHIB_AVE":-5.13,
    "SMILES":"N1C(C)(C)CC(CC1(C)C)OC(CCCCCCCCC(=O)OC(CC2(C)C)CC(N2)(C)C)=O",
    "HIT":0.0,
    "question":"Can N1C(C)(C)CC(CC1(C)C)OC(CCCCCCCCC(=O)OC(CC2(C)C)CC(N2)(C)C)=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":72124
  },
  {
    "COADD_ID":"CO-ADD:0231094",
    "INHIB_AVE":8.24,
    "SMILES":"C(=O)(Nc1cccc(C)c1)C\\C(\\C)=N\\NC(COc2ccccc2C)=O",
    "HIT":0.0,
    "question":"Can exposure to C(=O)(Nc1cccc(C)c1)C\\C(\\C)=N\\NC(COc2ccccc2C)=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":22348
  },
  {
    "COADD_ID":"CO-ADD:0299682",
    "INHIB_AVE":13.31,
    "SMILES":"c1(O2)c(c(n[nH]1)C)C(C(C#N)=C2N)c(cc3)ccc3N(C)C",
    "HIT":0.0,
    "question":"Does the proposed molecule c1(O2)c(c(n[nH]1)C)C(C(C#N)=C2N)c(cc3)ccc3N(C)C exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":10064
  },
  {
    "COADD_ID":"CO-ADD:0290889",
    "INHIB_AVE":-2.93,
    "SMILES":"S(=O)(=O)(c1c(Cl)ccc(Cl)c1)N2CCCC2C(O)=O",
    "HIT":0.0,
    "question":"Can S(=O)(=O)(c1c(Cl)ccc(Cl)c1)N2CCCC2C(O)=O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":67050
  },
  {
    "COADD_ID":"CO-ADD:0301830",
    "INHIB_AVE":-1.51,
    "SMILES":"c(c1c(s2)CCC1)(C3=O)c2N=CN3Cc4ccc(cc4C)C",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c(c1c(s2)CCC1)(C3=O)c2N=CN3Cc4ccc(cc4C)C?",
    "answer":"No",
    "_id":62769
  },
  {
    "COADD_ID":"CO-ADD:0323881",
    "INHIB_AVE":4.34,
    "SMILES":"S(=O)(=O)(NCc1ccccn1)c(c(C)ccc2c3c4c(cccc4)c(nn3)Nc5ccccc5)c2",
    "HIT":0.0,
    "question":"Does S(=O)(=O)(NCc1ccccn1)c(c(C)ccc2c3c4c(cccc4)c(nn3)Nc5ccccc5)c2 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":38654
  },
  {
    "COADD_ID":"CO-ADD:0259912",
    "INHIB_AVE":21.14,
    "SMILES":"c1(SCc2ccccc2)sc3c(ccc(c3)\\N=C\\c(ccc4c(cc5)ccc5[N+](=O)[O-])o4)n1",
    "HIT":0.0,
    "question":"Does c1(SCc2ccccc2)sc3c(ccc(c3)\\N=C\\c(ccc4c(cc5)ccc5[N+](=O)[O-])o4)n1 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":2272
  },
  {
    "COADD_ID":"CO-ADD:0162530",
    "INHIB_AVE":-2.36,
    "SMILES":"c12c(NC(CN=C1c3ccc(cc3)F)=O)c4c(cccc4)o2",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c12c(NC(CN=C1c3ccc(cc3)F)=O)c4c(cccc4)o2?",
    "answer":"No",
    "_id":65432
  },
  {
    "COADD_ID":"CO-ADD:0226079",
    "INHIB_AVE":9.67,
    "SMILES":"S(=O)(=O)(N(c1ccccc1)Cc2ccccc2Cl)c3cccn(c(nn4)CC)c34",
    "HIT":0.0,
    "question":"Can S(=O)(=O)(N(c1ccccc1)Cc2ccccc2Cl)c3cccn(c(nn4)CC)c34 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":17962
  },
  {
    "COADD_ID":"CO-ADD:0156160",
    "INHIB_AVE":3.66,
    "SMILES":"O=C(N\/C(S\/1)=N\\N=C\\C2=CC=C(N(C)C)C=C2)C1=C\/C3=CC=CC=C3F",
    "HIT":0.0,
    "question":"Does O=C(N\/C(S\/1)=N\\N=C\\C2=CC=C(N(C)C)C=C2)C1=C\/C3=CC=CC=C3F show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":41673
  },
  {
    "COADD_ID":"CO-ADD:0326698",
    "INHIB_AVE":10.05,
    "SMILES":"C1(c2ccc(c3n2)cccc3)=CNc(c4C1c5cccc(cccc6)c56)cccc4",
    "HIT":0.0,
    "question":"Can C1(c2ccc(c3n2)cccc3)=CNc(c4C1c5cccc(cccc6)c56)cccc4 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":16870
  },
  {
    "COADD_ID":"CO-ADD:0294430",
    "INHIB_AVE":6.02,
    "SMILES":"c1(nc(c2ccc(c(OC)c2)OC)cc3C(F)(F)F)n3nc(C(=O)Nc(cc(OC)cc4[N+](=O)[O-])c4)c1Cl",
    "HIT":0.0,
    "question":"Does the proposed molecule c1(nc(c2ccc(c(OC)c2)OC)cc3C(F)(F)F)n3nc(C(=O)Nc(cc(OC)cc4[N+](=O)[O-])c4)c1Cl exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":31177
  },
  {
    "COADD_ID":"CO-ADD:0283447",
    "INHIB_AVE":0.76,
    "SMILES":"C12(C(C(C)=O)=C(C)OC(N)=C1C#N)C3=C(N(C)C2=O)CC=CC3",
    "HIT":0.0,
    "question":"Can C12(C(C(C)=O)=C(C)OC(N)=C1C#N)C3=C(N(C)C2=O)CC=CC3 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":54473
  },
  {
    "COADD_ID":"CO-ADD:0227075",
    "INHIB_AVE":-7.27,
    "SMILES":"C(=O)(C(c1ccccc1)c2ccccc2)Nc3ccc(cc3OC)OC",
    "HIT":0.0,
    "question":"Does treatment with C(=O)(C(c1ccccc1)c2ccccc2)Nc3ccc(cc3OC)OC result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":75732
  },
  {
    "COADD_ID":"CO-ADD:0258948",
    "INHIB_AVE":1.92,
    "SMILES":"c1(ccn(C)n1)C(=O)NNC(CCC(O)=O)=O",
    "HIT":0.0,
    "question":"Can c1(ccn(C)n1)C(=O)NNC(CCC(O)=O)=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":49459
  },
  {
    "COADD_ID":"CO-ADD:0300509",
    "INHIB_AVE":6.8,
    "SMILES":"N1(\\N=C(\/C)\\c2ccccc2O)C(=O)c3c(NC1c4ccco4)cccc3",
    "HIT":0.0,
    "question":"Can N1(\\N=C(\/C)\\c2ccccc2O)C(=O)c3c(NC1c4ccco4)cccc3 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":27812
  },
  {
    "COADD_ID":"CO-ADD:0304489",
    "INHIB_AVE":-3.05,
    "SMILES":"c1(c(C)ccc(c1)NC(COc2ccc(cc2Cl)Cl)=O)N(C)C",
    "HIT":0.0,
    "question":"Does c1(c(C)ccc(c1)NC(COc2ccc(cc2Cl)Cl)=O)N(C)C demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":67371
  },
  {
    "COADD_ID":"CO-ADD:0328316",
    "INHIB_AVE":14.68,
    "SMILES":"c1(C(=O)c2ccc(cc2)F)oc3c(c(C)cc(C)n3)c1N",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(C(=O)c2ccc(cc2)F)oc3c(c(C)cc(C)n3)c1N?",
    "answer":"No",
    "_id":8021
  },
  {
    "COADD_ID":"CO-ADD:0242700",
    "INHIB_AVE":3.99,
    "SMILES":"C1(C(C)=O)=C(C)NC(=S)NC1c2ccc(cc2)Br",
    "HIT":0.0,
    "question":"Does C1(C(C)=O)=C(C)NC(=S)NC1c2ccc(cc2)Br show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":40211
  },
  {
    "COADD_ID":"CO-ADD:0321280",
    "INHIB_AVE":2.07,
    "SMILES":"C1(C#N)(C#N)C(N)=C(C#N)C(=CC1(C)c2c(C)non2)c3c(C)non3",
    "HIT":0.0,
    "question":"Can C1(C#N)(C#N)C(N)=C(C#N)C(=CC1(C)c2c(C)non2)c3c(C)non3 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":48797
  },
  {
    "COADD_ID":"CO-ADD:0310902",
    "INHIB_AVE":12.75,
    "SMILES":"[N+](=O)([O-])c1ccc(c2c1cccn2)N(CC3)CCN3C(=O)\\C=C\\c4ccc(cc4Cl)Cl",
    "HIT":0.0,
    "question":"Can [N+](=O)([O-])c1ccc(c2c1cccn2)N(CC3)CCN3C(=O)\\C=C\\c4ccc(cc4Cl)Cl act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":11031
  },
  {
    "COADD_ID":"CO-ADD:0163241",
    "INHIB_AVE":11.07,
    "SMILES":"n1c(N(CC2)CCO2)nc(nc1N(CC3)CCO3)N\\N=C\\c(ccc4c5ccc(cc5)Br)o4",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound n1c(N(CC2)CCO2)nc(nc1N(CC3)CCO3)N\\N=C\\c(ccc4c5ccc(cc5)Br)o4?",
    "answer":"No",
    "_id":14362
  },
  {
    "COADD_ID":"CO-ADD:0232062",
    "INHIB_AVE":3.54,
    "SMILES":"c1(ccc(c(cccc2)c12)Br)CC(=O)N\\N=C\\c3cc(OC)ccc3O",
    "HIT":0.0,
    "question":"Does c1(ccc(c(cccc2)c12)Br)CC(=O)N\\N=C\\c3cc(OC)ccc3O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":42199
  },
  {
    "COADD_ID":"CO-ADD:0332538",
    "INHIB_AVE":-1.2,
    "SMILES":"c1(ccc(cc1N(CC2)CCO2)N(CC3)CCN3C(=O)c4cccc(Br)c4)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(ccc(cc1N(CC2)CCO2)N(CC3)CCN3C(=O)c4cccc(Br)c4)[N+](=O)[O-]?",
    "answer":"No",
    "_id":61735
  },
  {
    "COADD_ID":"CO-ADD:0225461",
    "INHIB_AVE":-0.63,
    "SMILES":"C1(=N2)N(C=Cn(nc(c3ccc(cc3)Cl)c4)c14)C(N2CC(=O)Nc5ccccc5C)=O",
    "HIT":0.0,
    "question":"Is C1(=N2)N(C=Cn(nc(c3ccc(cc3)Cl)c4)c14)C(N2CC(=O)Nc5ccccc5C)=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":59830
  },
  {
    "COADD_ID":"CO-ADD:0324571",
    "INHIB_AVE":2.08,
    "SMILES":"[nH]1c(cccc2)c2c(CCNC(=O)\\C(\\NC(=O)c3ccc(cc3)OCC(C)C)=C\\c4ccco4)c1C",
    "HIT":0.0,
    "question":"Does treatment with [nH]1c(cccc2)c2c(CCNC(=O)\\C(\\NC(=O)c3ccc(cc3)OCC(C)C)=C\\c4ccco4)c1C result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":48747
  },
  {
    "COADD_ID":"CO-ADD:0293335",
    "INHIB_AVE":1.79,
    "SMILES":"C(C(=O)OC(C)(C)C)(=C(C)NC(=C1C#N)SCC(=O)Nc2cccc(C)c2C)C1c3ccc(cc3)Cl",
    "HIT":0.0,
    "question":"Does the proposed molecule C(C(=O)OC(C)(C)C)(=C(C)NC(=C1C#N)SCC(=O)Nc2cccc(C)c2C)C1c3ccc(cc3)Cl exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":50032
  },
  {
    "COADD_ID":"CO-ADD:0287564",
    "INHIB_AVE":-4.32,
    "SMILES":"C1(=O)Oc(c(c2)S1)cc(c2OC(=O)Nc3cccc(Cl)c3)Br",
    "HIT":0.0,
    "question":"Can exposure to C1(=O)Oc(c(c2)S1)cc(c2OC(=O)Nc3cccc(Cl)c3)Br lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":70449
  },
  {
    "COADD_ID":"CO-ADD:0302122",
    "INHIB_AVE":4.31,
    "SMILES":"c1(sccn1)NC(CC)=O",
    "HIT":0.0,
    "question":"Can exposure to c1(sccn1)NC(CC)=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":38757
  },
  {
    "COADD_ID":"CO-ADD:0148881",
    "INHIB_AVE":0.17,
    "SMILES":"c12c(cc(OCCO3)c3c1)noc2c4ccccc4",
    "HIT":0.0,
    "question":"Does c12c(cc(OCCO3)c3c1)noc2c4ccccc4 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":56806
  },
  {
    "COADD_ID":"CO-ADD:0329151",
    "INHIB_AVE":-0.27,
    "SMILES":"C(C(OC)=O)(=CN(CCCN1CCCC1=O)C=C2C(OC)=O)C2c3ccc(C)s3",
    "HIT":0.0,
    "question":"Can exposure to C(C(OC)=O)(=CN(CCCN1CCCC1=O)C=C2C(OC)=O)C2c3ccc(C)s3 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":58518
  },
  {
    "COADD_ID":"CO-ADD:0283380",
    "INHIB_AVE":7.34,
    "SMILES":"N(=C1SCC(=O)Nc2ccc(cn2)Br)C(=O)C(C(=O)N1)Cc3ccccc3",
    "HIT":0.0,
    "question":"Is N(=C1SCC(=O)Nc2ccc(cn2)Br)C(=O)C(C(=O)N1)Cc3ccccc3 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":25712
  },
  {
    "COADD_ID":"CO-ADD:0306253",
    "INHIB_AVE":12.75,
    "SMILES":"C1(C(OCCOc2ccccc2)=O)=C(C)NC(=C3C1c4cc(Br)ccc4OC)CCCC3=O",
    "HIT":0.0,
    "question":"Does C1(C(OCCOc2ccccc2)=O)=C(C)NC(=C3C1c4cc(Br)ccc4OC)CCCC3=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":11037
  },
  {
    "COADD_ID":"CO-ADD:0320636",
    "INHIB_AVE":4.38,
    "SMILES":"C12(C=Cc3c(ccc(cccc4)c34)O1)C(C)(C)c(c5N2CC(=O)NCc6ccccc6Cl)cccc5",
    "HIT":0.0,
    "question":"Does C12(C=Cc3c(ccc(cccc4)c34)O1)C(C)(C)c(c5N2CC(=O)NCc6ccccc6Cl)cccc5 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":38445
  },
  {
    "COADD_ID":"CO-ADD:0234937",
    "INHIB_AVE":-4.66,
    "SMILES":"c1(Nc2ccccc2)nc(N\\N=C\\c3cccc(Cl)c3)nc(NCc4ccccc4)n1",
    "HIT":0.0,
    "question":"Can c1(Nc2ccccc2)nc(N\\N=C\\c3cccc(Cl)c3)nc(NCc4ccccc4)n1 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":71157
  },
  {
    "COADD_ID":"CO-ADD:0156454",
    "INHIB_AVE":-5.28,
    "SMILES":"O=C(CNC1=C(C=CC=C2)C2=CC=C1)N\/N=C(C)\/C3=CC=C(C=C3)C(C)(C)C",
    "HIT":0.0,
    "question":"Can O=C(CNC1=C(C=CC=C2)C2=CC=C1)N\/N=C(C)\/C3=CC=C(C=C3)C(C)(C)C effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":72419
  },
  {
    "COADD_ID":"CO-ADD:0250321",
    "INHIB_AVE":5.82,
    "SMILES":"N(c1cccc(cccc2)c12)(C(=O)C(C34)C(C=C5)OC35C)C4=O",
    "HIT":0.0,
    "question":"Can exposure to N(c1cccc(cccc2)c12)(C(=O)C(C34)C(C=C5)OC35C)C4=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":32003
  },
  {
    "COADD_ID":"CO-ADD:0326573",
    "INHIB_AVE":17.36,
    "SMILES":"c1(c(cccn1)C)NCC(O)COc2ccccc2",
    "HIT":0.0,
    "question":"Can c1(c(cccn1)C)NCC(O)COc2ccccc2 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":4923
  },
  {
    "COADD_ID":"CO-ADD:0223674",
    "INHIB_AVE":15.08,
    "SMILES":"c1(\\C=N\\NC(=O)C(C)Oc(cc2)ccc2Br)c(cccc1Cl)Cl",
    "HIT":0.0,
    "question":"Can c1(\\C=N\\NC(=O)C(C)Oc(cc2)ccc2Br)c(cccc1Cl)Cl act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":7503
  },
  {
    "COADD_ID":"CO-ADD:0302673",
    "INHIB_AVE":3.27,
    "SMILES":"S(=O)(=O)(c(ccc(c1C(=O)Nc(cc2)ccc2OC(=O)c3cccs3)Cl)c1)N(CC4)CCO4",
    "HIT":0.0,
    "question":"Does treatment with S(=O)(=O)(c(ccc(c1C(=O)Nc(cc2)ccc2OC(=O)c3cccs3)Cl)c1)N(CC4)CCO4 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":43430
  },
  {
    "COADD_ID":"CO-ADD:0159782",
    "INHIB_AVE":-13.24,
    "SMILES":"O=S(N=C1NC2=C(OC)C=CC(OC)=C2)(C3=C1C=CC([N+]([O-])=O)=C3)=O",
    "HIT":0.0,
    "question":"Is O=S(N=C1NC2=C(OC)C=CC(OC)=C2)(C3=C1C=CC([N+]([O-])=O)=C3)=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":80637
  },
  {
    "COADD_ID":"CO-ADD:0286815",
    "INHIB_AVE":2.58,
    "SMILES":"S(N)(=O)(=O)c1cc(C(C)(C)C)cc(C(C)(C)C)c1O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound S(N)(=O)(=O)c1cc(C(C)(C)C)cc(C(C)(C)C)c1O?",
    "answer":"No",
    "_id":46527
  },
  {
    "COADD_ID":"CO-ADD:0230544",
    "INHIB_AVE":3.51,
    "SMILES":"C(Cc1ccccc1)(=O)N\\N=C\\C=C\\c(cc2)ccc2N(C)C",
    "HIT":0.0,
    "question":"Does treatment with C(Cc1ccccc1)(=O)N\\N=C\\C=C\\c(cc2)ccc2N(C)C result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":42346
  },
  {
    "COADD_ID":"CO-ADD:0166344",
    "INHIB_AVE":2.93,
    "SMILES":"C(=O)(N\\N=C\\c(cc1)ccc1C)C(=O)Nc2c(C)cccc2C",
    "HIT":0.0,
    "question":"Does C(=O)(N\\N=C\\c(cc1)ccc1C)C(=O)Nc2c(C)cccc2C demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":44993
  },
  {
    "COADD_ID":"CO-ADD:0160588",
    "INHIB_AVE":-3.44,
    "SMILES":"O=C(N\/N=C\/C(C(Cl)=C1)=CC=C1Cl)C(NC(C=CC=C2)=C2OC(F)(F)C(F)F)=O",
    "HIT":0.0,
    "question":"Does treatment with O=C(N\/N=C\/C(C(Cl)=C1)=CC=C1Cl)C(NC(C=CC=C2)=C2OC(F)(F)C(F)F)=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":68353
  },
  {
    "COADD_ID":"CO-ADD:0321001",
    "INHIB_AVE":12.18,
    "SMILES":"C12(c3c(cccc3)C(=NN1c4ccccc4)C)SC(=NN2c5ccccc5)C(OC)=O",
    "HIT":0.0,
    "question":"Does treatment with C12(c3c(cccc3)C(=NN1c4ccccc4)C)SC(=NN2c5ccccc5)C(OC)=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":12104
  },
  {
    "COADD_ID":"CO-ADD:0157830",
    "INHIB_AVE":-0.74,
    "SMILES":"O=C1\/C(N=C(C2=CC=CC(C)=C2)O1)=C\\C3=CC=C(C)C=C3",
    "HIT":0.0,
    "question":"Can exposure to O=C1\/C(N=C(C2=CC=CC(C)=C2)O1)=C\\C3=CC=C(C)C=C3 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":60191
  },
  {
    "COADD_ID":"CO-ADD:0330749",
    "INHIB_AVE":5.3,
    "SMILES":"C1(O)(C(F)(F)F)c2c(OC1=O)ccc(OC)c2",
    "HIT":0.0,
    "question":"Does the proposed molecule C1(O)(C(F)(F)F)c2c(OC1=O)ccc(OC)c2 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":34323
  },
  {
    "COADD_ID":"CO-ADD:0303887",
    "INHIB_AVE":8.5,
    "SMILES":"C12=C(CC(C)(C)CC1=O)c3c(ccc4c3cccn4)NC2c5ccc(cc5)CC",
    "HIT":0.0,
    "question":"Can C12=C(CC(C)(C)CC1=O)c3c(ccc4c3cccn4)NC2c5ccc(cc5)CC effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":21453
  },
  {
    "COADD_ID":"CO-ADD:0253172",
    "INHIB_AVE":0.95,
    "SMILES":"C(C#N)(C1c(cc2)ccc2N(C)C)=C(N)N(C(CC(C)(C)CC3=O)=C13)c(cc4)ccc4[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Can exposure to C(C#N)(C1c(cc2)ccc2N(C)C)=C(N)N(C(CC(C)(C)CC3=O)=C13)c(cc4)ccc4[N+](=O)[O-] lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":53670
  },
  {
    "COADD_ID":"CO-ADD:0323853",
    "INHIB_AVE":-1.8,
    "SMILES":"S(=O)(=O)(c1ccc(c(OC)c1)OC)N(CC2)CCN2C34CC(CC5C3)CC(C5)C4",
    "HIT":0.0,
    "question":"Does treatment with S(=O)(=O)(c1ccc(c(OC)c1)OC)N(CC2)CCN2C34CC(CC5C3)CC(C5)C4 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":63740
  },
  {
    "COADD_ID":"CO-ADD:0229633",
    "INHIB_AVE":15.17,
    "SMILES":"c1(Nc2ccccc2OC)c(c(C)nc(Nc(cc3)ccc3C)n1)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Does treatment with c1(Nc2ccccc2OC)c(c(C)nc(Nc(cc3)ccc3C)n1)[N+](=O)[O-] result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":7379
  },
  {
    "COADD_ID":"CO-ADD:0305986",
    "INHIB_AVE":6.77,
    "SMILES":"N1(CCC2=CCCCC2)C(=O)c3c(cccc3)C1=O",
    "HIT":0.0,
    "question":"Can N1(CCC2=CCCCC2)C(=O)c3c(cccc3)C1=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":27950
  },
  {
    "COADD_ID":"CO-ADD:0292571",
    "INHIB_AVE":2.44,
    "SMILES":"c(c1c(s2)CCCC1)(C3=O)c2N=C(SCc(cc4)ccc4OC(F)(F)C(F)F)N3c5ccccc5",
    "HIT":0.0,
    "question":"Does c(c1c(s2)CCCC1)(C3=O)c2N=C(SCc(cc4)ccc4OC(F)(F)C(F)F)N3c5ccccc5 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":47116
  },
  {
    "COADD_ID":"CO-ADD:0243913",
    "INHIB_AVE":5.18,
    "SMILES":"C(C(NC=C1C(OCC)=O)=O)(C(CC(NCCc(ccc2F)cc2)=O)c3c(OC)c4c(OCO4)c(OC)c3)=C1O",
    "HIT":0.0,
    "question":"Does the proposed molecule C(C(NC=C1C(OCC)=O)=O)(C(CC(NCCc(ccc2F)cc2)=O)c3c(OC)c4c(OCO4)c(OC)c3)=C1O exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":34805
  },
  {
    "COADD_ID":"CO-ADD:0299641",
    "INHIB_AVE":-3.02,
    "SMILES":"c1([nH]c(c2n1)cccc2)Sc(n3)nc(nc3Nc(cc4)ccc4C)Nc(cc5)ccc5C",
    "HIT":0.0,
    "question":"Is c1([nH]c(c2n1)cccc2)Sc(n3)nc(nc3Nc(cc4)ccc4C)Nc(cc5)ccc5C capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":67280
  },
  {
    "COADD_ID":"CO-ADD:0329642",
    "INHIB_AVE":0.77,
    "SMILES":"S1(=O)(=O)c2c(c3N1Cc4ccccn4)c(ccc2)ccc3",
    "HIT":0.0,
    "question":"Is S1(=O)(=O)c2c(c3N1Cc4ccccn4)c(ccc2)ccc3 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":54448
  },
  {
    "COADD_ID":"CO-ADD:0234356",
    "INHIB_AVE":-3.68,
    "SMILES":"c(C#N)(c(N)oc1c2ccccc2)c1c3ccccc3",
    "HIT":0.0,
    "question":"Can exposure to c(C#N)(c(N)oc1c2ccccc2)c1c3ccccc3 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":68976
  },
  {
    "COADD_ID":"CO-ADD:0254054",
    "INHIB_AVE":-2.51,
    "SMILES":"c1(cccs1)C(=O)\\C=C\\c(ccc(c2OC)OC)c2",
    "HIT":0.0,
    "question":"Can exposure to c1(cccs1)C(=O)\\C=C\\c(ccc(c2OC)OC)c2 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":65842
  },
  {
    "COADD_ID":"CO-ADD:0258453",
    "INHIB_AVE":0.72,
    "SMILES":"N1(C(CCCC2=O)=C2C(C(C#N)=C1N)c(cc3OC)cc(c3OC)OC)c4sc(c5c4C(OCC)=O)CCCCC5",
    "HIT":0.0,
    "question":"Does N1(C(CCCC2=O)=C2C(C(C#N)=C1N)c(cc3OC)cc(c3OC)OC)c4sc(c5c4C(OCC)=O)CCCCC5 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":54641
  },
  {
    "COADD_ID":"CO-ADD:0328581",
    "INHIB_AVE":6.64,
    "SMILES":"C1(C(F)(F)F)(NC(=O)c2ccco2)C(=O)NC3=C1C(=O)NC(N3CCc(ccc(c4OCC)OCC)c4)=O",
    "HIT":0.0,
    "question":"Does treatment with C1(C(F)(F)F)(NC(=O)c2ccco2)C(=O)NC3=C1C(=O)NC(N3CCc(ccc(c4OCC)OCC)c4)=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":28540
  },
  {
    "COADD_ID":"CO-ADD:0137573",
    "INHIB_AVE":100.38,
    "SMILES":"O=C(NCCN1CCOCC1)C2=CC(NC(C3=CC(NC(C4=CN=C(\/C=C\/C5=CC=C(OC)C=C5)C=C4)=O)=CN3C)=O)=CN2CCCC6=CN(CCC7=CC=CC=C7)N=N6",
    "HIT":1.0,
    "question":"Is O=C(NCCN1CCOCC1)C2=CC(NC(C3=CC(NC(C4=CN=C(\/C=C\/C5=CC=C(OC)C=C5)C=C4)=O)=CN3C)=O)=CN2CCCC6=CN(CCC7=CC=CC=C7)N=N6 effective in eliminating E. coli under experimental conditions?",
    "answer":"Yes",
    "_id":194
  },
  {
    "COADD_ID":"CO-ADD:0318804",
    "INHIB_AVE":9.14,
    "SMILES":"C1(NC(COc2ccc(cc2C3CCCCC3)Cl)=O)=C(C)N(N(c4ccccc4)C1=O)C",
    "HIT":0.0,
    "question":"Does the proposed molecule C1(NC(COc2ccc(cc2C3CCCCC3)Cl)=O)=C(C)N(N(c4ccccc4)C1=O)C exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":19472
  },
  {
    "COADD_ID":"CO-ADD:0223565",
    "INHIB_AVE":-8.1,
    "SMILES":"C(C)(CN1CC2(CN3C1c4ccc(cc4)Cl)C)(C3)C2=O",
    "HIT":0.0,
    "question":"Does treatment with C(C)(CN1CC2(CN3C1c4ccc(cc4)Cl)C)(C3)C2=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":76850
  },
  {
    "COADD_ID":"CO-ADD:0301156",
    "INHIB_AVE":2.3,
    "SMILES":"N1(C(=O)c2cccc(Cl)c2)N=C(CC1(O)C3CCCCC3)C",
    "HIT":0.0,
    "question":"Does treatment with N1(C(=O)c2cccc(Cl)c2)N=C(CC1(O)C3CCCCC3)C result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":47772
  },
  {
    "COADD_ID":"CO-ADD:0301134",
    "INHIB_AVE":3.34,
    "SMILES":"[N+](=O)([O-])c(ccc(c1C#N)Oc(cc2)ccc2\\C=N\\N=C(\/SCC3=O)\\N3)c1",
    "HIT":0.0,
    "question":"Is [N+](=O)([O-])c(ccc(c1C#N)Oc(cc2)ccc2\\C=N\\N=C(\/SCC3=O)\\N3)c1 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":43105
  },
  {
    "COADD_ID":"CO-ADD:0136458",
    "INHIB_AVE":6.47,
    "SMILES":"C1CC(C(C(=O)N(C(C(O)=O)CCC(N)=O)C2=O)C23)CC13",
    "HIT":0.0,
    "question":"Can C1CC(C(C(=O)N(C(C(O)=O)CCC(N)=O)C2=O)C23)CC13 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":29253
  },
  {
    "COADD_ID":"CO-ADD:0252401",
    "INHIB_AVE":18.48,
    "SMILES":"n1c(N(CC2)CCO2)nc(nc1N(CC3)CCO3)N\\N=C\\c(c(cccc4)c4n5Cc6ccc(cc6Cl)Cl)c5.Cl",
    "HIT":0.0,
    "question":"Can n1c(N(CC2)CCO2)nc(nc1N(CC3)CCO3)N\\N=C\\c(c(cccc4)c4n5Cc6ccc(cc6Cl)Cl)c5.Cl act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":3915
  },
  {
    "COADD_ID":"CO-ADD:0163027",
    "INHIB_AVE":3.57,
    "SMILES":"N1(c2ccccc2OC)C(=O)c(c3C1=O)ccc(C(OC)=O)c3",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound N1(c2ccccc2OC)C(=O)c(c3C1=O)ccc(C(OC)=O)c3?",
    "answer":"No",
    "_id":42085
  },
  {
    "COADD_ID":"CO-ADD:0245974",
    "INHIB_AVE":20.14,
    "SMILES":"c1(Nc(cc2)ccc2OC)nc(N\\N=C\\c3cc(Br)ccc3OCc4ccccc4)nc(NCc5ccco5)n1",
    "HIT":0.0,
    "question":"Can c1(Nc(cc2)ccc2OC)nc(N\\N=C\\c3cc(Br)ccc3OCc4ccccc4)nc(NCc5ccco5)n1 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":2803
  },
  {
    "COADD_ID":"CO-ADD:0252958",
    "INHIB_AVE":2.61,
    "SMILES":"S(CCCCCCCCCC)(=O)(=O)Nc(cc1c(c2Br)cccn1)c2",
    "HIT":0.0,
    "question":"Does the proposed molecule S(CCCCCCCCCC)(=O)(=O)Nc(cc1c(c2Br)cccn1)c2 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":46363
  },
  {
    "COADD_ID":"CO-ADD:0162216",
    "INHIB_AVE":11.41,
    "SMILES":"c1(N2CCCC2)nc(N\\N=C\\c(cc(Br)cc3Br)c3O)nc(Nc(cc4)ccc4[N+](=O)[O-])n1",
    "HIT":0.0,
    "question":"Can c1(N2CCCC2)nc(N\\N=C\\c(cc(Br)cc3Br)c3O)nc(Nc(cc4)ccc4[N+](=O)[O-])n1 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":13643
  },
  {
    "COADD_ID":"CO-ADD:0257548",
    "INHIB_AVE":9.89,
    "SMILES":"c1(SCC(=O)Nc(cc2)cc(c2NC(CSc3oc(c4n3)cccc4)=O)Cl)oc(c5n1)cccc5",
    "HIT":0.0,
    "question":"Is c1(SCC(=O)Nc(cc2)cc(c2NC(CSc3oc(c4n3)cccc4)=O)Cl)oc(c5n1)cccc5 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":17307
  },
  {
    "COADD_ID":"CO-ADD:0323571",
    "INHIB_AVE":2.03,
    "SMILES":"c1(ccc(cc1N(CC2)CCN2Cc3ccccc3)N4CCCC4)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Does c1(ccc(cc1N(CC2)CCN2Cc3ccccc3)N4CCCC4)[N+](=O)[O-] demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":48945
  },
  {
    "COADD_ID":"CO-ADD:0252212",
    "INHIB_AVE":-3.92,
    "SMILES":"c1(\\C=N\/NC(=O)c2ccc(cc2)Br)cc(C)ccc1O",
    "HIT":0.0,
    "question":"Can c1(\\C=N\/NC(=O)c2ccc(cc2)Br)cc(C)ccc1O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":69562
  },
  {
    "COADD_ID":"CO-ADD:0162406",
    "INHIB_AVE":6.17,
    "SMILES":"n1(\\N=C\\c(cccc2[N+](=O)[O-])c2)c(CCl)nnc1CCl",
    "HIT":0.0,
    "question":"Does n1(\\N=C\\c(cccc2[N+](=O)[O-])c2)c(CCl)nnc1CCl demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":30557
  },
  {
    "COADD_ID":"CO-ADD:0234983",
    "INHIB_AVE":-3.66,
    "SMILES":"c1(c(O)c(\\C=N\\NC(=O)Cc2cccc(cccc3)c23)cc(c1)[N+](=O)[O-])[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Is c1(c(O)c(\\C=N\\NC(=O)Cc2cccc(cccc3)c23)cc(c1)[N+](=O)[O-])[N+](=O)[O-] effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":68933
  },
  {
    "COADD_ID":"CO-ADD:0323540",
    "INHIB_AVE":23.53,
    "SMILES":"C(c1c(cccc1)NC2(C)C)(\\C(=N\\c(cc3)ccc3S(=O)(=O)NC(c4ccccc4)=O)\\SS5)=C25",
    "HIT":0.0,
    "question":"Does the proposed molecule C(c1c(cccc1)NC2(C)C)(\\C(=N\\c(cc3)ccc3S(=O)(=O)NC(c4ccccc4)=O)\\SS5)=C25 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":1483
  },
  {
    "COADD_ID":"CO-ADD:0162512",
    "INHIB_AVE":15.79,
    "SMILES":"N1(C(=O)c2c(cc(cc2)Oc(cccc3[N+](=O)[O-])c3)C1=O)C4=CNC(NC4=O)=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound N1(C(=O)c2c(cc(cc2)Oc(cccc3[N+](=O)[O-])c3)C1=O)C4=CNC(NC4=O)=O?",
    "answer":"No",
    "_id":6588
  },
  {
    "COADD_ID":"CO-ADD:0330925",
    "INHIB_AVE":-12.25,
    "SMILES":"c1(C#N)c(COC)cc(nc1SCC(=O)Nc(cccc2C(F)(F)F)c2)C",
    "HIT":0.0,
    "question":"Can c1(C#N)c(COC)cc(nc1SCC(=O)Nc(cccc2C(F)(F)F)c2)C act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":80183
  },
  {
    "COADD_ID":"CO-ADD:0254004",
    "INHIB_AVE":7.63,
    "SMILES":"S(C)(=O)(=O)N(c1ccc(cc1)C)CC(=O)N\\N=C(\/C)\\c(cccc2NC(=O)c3cccc(Cl)c3)c2",
    "HIT":0.0,
    "question":"Is S(C)(=O)(=O)N(c1ccc(cc1)C)CC(=O)N\\N=C(\/C)\\c(cccc2NC(=O)c3cccc(Cl)c3)c2 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":24549
  },
  {
    "COADD_ID":"CO-ADD:0217891",
    "INHIB_AVE":3.86,
    "SMILES":"N1(CCCCC1)C(=O)COc(cc2)ccc2C=O",
    "HIT":0.0,
    "question":"Can N1(CCCCC1)C(=O)COc(cc2)ccc2C=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":40786
  },
  {
    "COADD_ID":"CO-ADD:0292954",
    "INHIB_AVE":1.81,
    "SMILES":"C(C(=O)c1ccc(cc1)Cl)(C2c(cc3)ccc3N(C)C)=C(O)C(N2c4ccc(cc4)OC)=O",
    "HIT":0.0,
    "question":"Does the proposed molecule C(C(=O)c1ccc(cc1)Cl)(C2c(cc3)ccc3N(C)C)=C(O)C(N2c4ccc(cc4)OC)=O exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":49965
  },
  {
    "COADD_ID":"CO-ADD:0155857",
    "INHIB_AVE":-13.15,
    "SMILES":"O=C(C(NCCN1CCOCC1)=O)NC(C)C2=CC=CC=C2",
    "HIT":0.0,
    "question":"Does O=C(C(NCCN1CCOCC1)=O)NC(C)C2=CC=CC=C2 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":80579
  },
  {
    "COADD_ID":"CO-ADD:0286437",
    "INHIB_AVE":-2.86,
    "SMILES":"n1(c(cc(C)cc2C)c2n3)c3S\\C(=C\/c(ccc4c5c(OC)ccc(c5)[N+](=O)[O-])o4)\\C1=O",
    "HIT":0.0,
    "question":"Does n1(c(cc(C)cc2C)c2n3)c3S\\C(=C\/c(ccc4c5c(OC)ccc(c5)[N+](=O)[O-])o4)\\C1=O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":66872
  },
  {
    "COADD_ID":"CO-ADD:0215023",
    "INHIB_AVE":0.28,
    "SMILES":"N1(c2cccc(c2)C#C)C(=O)c(c3C1=O)ccc(C(=O)c(cc4)ccc4C(O)=O)c3",
    "HIT":0.0,
    "question":"Does N1(c2cccc(c2)C#C)C(=O)c(c3C1=O)ccc(C(=O)c(cc4)ccc4C(O)=O)c3 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":56330
  },
  {
    "COADD_ID":"CO-ADD:0244492",
    "INHIB_AVE":22.61,
    "SMILES":"C1(C)(C)C(C1\\C=C(\/Cl)\\Cl)C(=O)NNC(=O)c(cccn2)c2",
    "HIT":0.0,
    "question":"Does the proposed molecule C1(C)(C)C(C1\\C=C(\/Cl)\\Cl)C(=O)NNC(=O)c(cccn2)c2 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":1740
  },
  {
    "COADD_ID":"CO-ADD:0323861",
    "INHIB_AVE":7.08,
    "SMILES":"S(=O)(=O)(N(CC1)CCN1C23CC4CC(CC(C4)C2)C3)c5c(OCC)ccc(OCC)c5",
    "HIT":0.0,
    "question":"Is S(=O)(=O)(N(CC1)CCN1C23CC4CC(CC(C4)C2)C3)c5c(OCC)ccc(OCC)c5 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":26659
  },
  {
    "COADD_ID":"CO-ADD:0283508",
    "INHIB_AVE":-4.39,
    "SMILES":"N12C(S\\C(=C\\c(cc3)ccc3Cl)\\C1=O)=NC(C)=C(C(OCC)=O)C2c4ccc(c(cccc5)c45)OC",
    "HIT":0.0,
    "question":"Can N12C(S\\C(=C\\c(cc3)ccc3Cl)\\C1=O)=NC(C)=C(C(OCC)=O)C2c4ccc(c(cccc5)c45)OC act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":70599
  },
  {
    "COADD_ID":"CO-ADD:0136526",
    "INHIB_AVE":-1.87,
    "SMILES":"n1ccc(cccc2)c2c1C=Cc(ccc3)c(OC)c3OC",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound n1ccc(cccc2)c2c1C=Cc(ccc3)c(OC)c3OC?",
    "answer":"No",
    "_id":63962
  },
  {
    "COADD_ID":"CO-ADD:0295120",
    "INHIB_AVE":-20.23,
    "SMILES":"c1(Oc2cccc(c2)NC(COc3ccc(cc3Cl)Cl)=O)nc(C)cc(C)c1C#N",
    "HIT":0.0,
    "question":"Does treatment with c1(Oc2cccc(c2)NC(COc3ccc(cc3Cl)Cl)=O)nc(C)cc(C)c1C#N result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":82188
  },
  {
    "COADD_ID":"CO-ADD:0292507",
    "INHIB_AVE":13.35,
    "SMILES":"C1(C(OCC)=O)=C(C)NC(=O)CC1c2c(cccc2F)Cl",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C1(C(OCC)=O)=C(C)NC(=O)CC1c2c(cccc2F)Cl?",
    "answer":"No",
    "_id":9999
  },
  {
    "COADD_ID":"CO-ADD:0332017",
    "INHIB_AVE":6.62,
    "SMILES":"C(=O)(c1cccc(C)c1)NC(c2ccc(cc2)OC)CC(O)=O",
    "HIT":0.0,
    "question":"Is C(=O)(c1cccc(C)c1)NC(c2ccc(cc2)OC)CC(O)=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":28628
  },
  {
    "COADD_ID":"CO-ADD:0136133",
    "INHIB_AVE":4.02,
    "SMILES":"n1c(C(N)=O)c(N=NN(CCCl)C2=O)n2c1",
    "HIT":0.0,
    "question":"Is n1c(C(N)=O)c(N=NN(CCCl)C2=O)n2c1 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":40103
  },
  {
    "COADD_ID":"CO-ADD:0321350",
    "INHIB_AVE":0.04,
    "SMILES":"n1(c2c(n3)cccc2)c3S\\C(=C\/c4cccc(c4)OCc5ccccc5F)\\C1=O",
    "HIT":0.0,
    "question":"Can n1(c2c(n3)cccc2)c3S\\C(=C\/c4cccc(c4)OCc5ccccc5F)\\C1=O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":57294
  },
  {
    "COADD_ID":"CO-ADD:0162896",
    "INHIB_AVE":2.8,
    "SMILES":"C(=N\/c1ccccc1)(\/SC=C2c3ccccc3)\\N2c4ccccc4",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C(=N\/c1ccccc1)(\/SC=C2c3ccccc3)\\N2c4ccccc4?",
    "answer":"No",
    "_id":45559
  },
  {
    "COADD_ID":"CO-ADD:0234315",
    "INHIB_AVE":8.28,
    "SMILES":"c1(c(ccc(c1)[N+](=O)[O-])Oc2cccc(c2)\\C=N\\NC(COc3ccccc3C)=O)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Does the proposed molecule c1(c(ccc(c1)[N+](=O)[O-])Oc2cccc(c2)\\C=N\\NC(COc3ccccc3C)=O)[N+](=O)[O-] exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":22200
  },
  {
    "COADD_ID":"CO-ADD:0161726",
    "INHIB_AVE":11.49,
    "SMILES":"c1(oc2c(ccc(C)c2)n1)c3cc(ccc3O)\\N=C\\c(cc(Cl)cc4I)c4O",
    "HIT":0.0,
    "question":"Does treatment with c1(oc2c(ccc(C)c2)n1)c3cc(ccc3O)\\N=C\\c(cc(Cl)cc4I)c4O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":13464
  },
  {
    "COADD_ID":"CO-ADD:0278114",
    "INHIB_AVE":13.47,
    "SMILES":"C1(=C(CC(C)(C)CC1=O)OC(=C23)CC(CC2=O)(C)C)C3c4ccccc4OC",
    "HIT":0.0,
    "question":"Can C1(=C(CC(C)(C)CC1=O)OC(=C23)CC(CC2=O)(C)C)C3c4ccccc4OC effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":9809
  },
  {
    "COADD_ID":"CO-ADD:0279089",
    "INHIB_AVE":7.36,
    "SMILES":"c1(C(=O)Nc2sc(c3c2C(OCC)=O)CCCC3)cn(nc1C45CC6CC(CC(C6)C4)C5)c7ccccc7",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(C(=O)Nc2sc(c3c2C(OCC)=O)CCCC3)cn(nc1C45CC6CC(CC(C6)C4)C5)c7ccccc7?",
    "answer":"No",
    "_id":25632
  },
  {
    "COADD_ID":"CO-ADD:0235450",
    "INHIB_AVE":-1.19,
    "SMILES":"s1c(c2ccccc2)nnc1NC(=O)c3ccccc3Br",
    "HIT":0.0,
    "question":"Does treatment with s1c(c2ccccc2)nnc1NC(=O)c3ccccc3Br result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":61701
  },
  {
    "COADD_ID":"CO-ADD:0302126",
    "INHIB_AVE":4.35,
    "SMILES":"N1(C(=O)c(c2C1=O)ccc(c2)[N+](=O)[O-])c3nnc(SCC)s3",
    "HIT":0.0,
    "question":"Does the proposed molecule N1(C(=O)c(c2C1=O)ccc(c2)[N+](=O)[O-])c3nnc(SCC)s3 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":38575
  },
  {
    "COADD_ID":"CO-ADD:0243288",
    "INHIB_AVE":18.36,
    "SMILES":"c(CC(C1)ON=C1C(N)=O)(c(OC)c2OC)c(Br)c(c23)OCO3",
    "HIT":0.0,
    "question":"Is c(CC(C1)ON=C1C(N)=O)(c(OC)c2OC)c(Br)c(c23)OCO3 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":4014
  },
  {
    "COADD_ID":"CO-ADD:0252493",
    "INHIB_AVE":4.7,
    "SMILES":"C(\/NC(c1ccccc1)=O)(\\C(=O)N\\N=C\\c2c(cccc2Cl)Cl)=C\/c3cccs3",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C(\/NC(c1ccccc1)=O)(\\C(=O)N\\N=C\\c2c(cccc2Cl)Cl)=C\/c3cccs3?",
    "answer":"No",
    "_id":37004
  },
  {
    "COADD_ID":"CO-ADD:0217589",
    "INHIB_AVE":-0.71,
    "SMILES":"c1(OC)c(OC)ccc(\\C=N\\NC(=O)c(cc2OC)cc(c2OC)OC)c1OC",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(OC)c(OC)ccc(\\C=N\\NC(=O)c(cc2OC)cc(c2OC)OC)c1OC?",
    "answer":"No",
    "_id":60107
  },
  {
    "COADD_ID":"CO-ADD:0163993",
    "INHIB_AVE":13.88,
    "SMILES":"O=C(N1N(S(=O)(C2=CC=C([N+]([O-])=O)C=C2)=O)C3C(CCC3)C1O)OC(C)(C)C",
    "HIT":0.0,
    "question":"Can O=C(N1N(S(=O)(C2=CC=C([N+]([O-])=O)C=C2)=O)C3C(CCC3)C1O)OC(C)(C)C effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":9230
  },
  {
    "COADD_ID":"CO-ADD:0285792",
    "INHIB_AVE":-6.34,
    "SMILES":"C1(C(CC(NC1(C)C)(C)C)NC(=O)C(F)(F)F)NC(=O)C(F)(F)F",
    "HIT":0.0,
    "question":"Does treatment with C1(C(CC(NC1(C)C)(C)C)NC(=O)C(F)(F)F)NC(=O)C(F)(F)F result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":74305
  },
  {
    "COADD_ID":"CO-ADD:0163421",
    "INHIB_AVE":-7.54,
    "SMILES":"c1(c2ccc(cc2)I)ccc(\\C=N\/NC(COc3cccc(C)c3)=O)o1",
    "HIT":0.0,
    "question":"Does c1(c2ccc(cc2)I)ccc(\\C=N\/NC(COc3cccc(C)c3)=O)o1 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":76127
  },
  {
    "COADD_ID":"CO-ADD:0260158",
    "INHIB_AVE":13.53,
    "SMILES":"n1(c2c(nc1SC)cccc2)CC(=O)N(CC3)CCO3",
    "HIT":0.0,
    "question":"Can n1(c2c(nc1SC)cccc2)CC(=O)N(CC3)CCO3 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":9726
  },
  {
    "COADD_ID":"CO-ADD:0230723",
    "INHIB_AVE":10.68,
    "SMILES":"C(=O)(Nc(cc1)ccc1N(C)C)C\\C(\\C)=N\\NC(COc2ccc(cc2Br)C)=O",
    "HIT":0.0,
    "question":"Can C(=O)(Nc(cc1)ccc1N(C)C)C\\C(\\C)=N\\NC(COc2ccc(cc2Br)C)=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":15262
  },
  {
    "COADD_ID":"CO-ADD:0253290",
    "INHIB_AVE":10.27,
    "SMILES":"C1(=O)OC2(C(=C)N1CC)CCCCC2",
    "HIT":0.0,
    "question":"Does C1(=O)OC2(C(=C)N1CC)CCCCC2 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":16304
  },
  {
    "COADD_ID":"CO-ADD:0250647",
    "INHIB_AVE":-2.48,
    "SMILES":"c(C#N)(c(N)n(n1)CCO)c1\\C(\\C#N)=C\\c2cc(Br)ccc2OC(C)C",
    "HIT":0.0,
    "question":"Does treatment with c(C#N)(c(N)n(n1)CCO)c1\\C(\\C#N)=C\\c2cc(Br)ccc2OC(C)C result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":65766
  },
  {
    "COADD_ID":"CO-ADD:0253137",
    "INHIB_AVE":-15.82,
    "SMILES":"c(C(F)(F)F)(c(F)c1F)c(F)c(c1N\\N=C\/c(cc(cc2[N+](=O)[O-])[N+](=O)[O-])c2O)F",
    "HIT":0.0,
    "question":"Does treatment with c(C(F)(F)F)(c(F)c1F)c(F)c(c1N\\N=C\/c(cc(cc2[N+](=O)[O-])[N+](=O)[O-])c2O)F result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":81518
  },
  {
    "COADD_ID":"CO-ADD:0257775",
    "INHIB_AVE":5.68,
    "SMILES":"C(=N\/c(cc1)ccc1C)(\/S\\C(\\C2=O)=C\\c(ccc(c3)N(CC)CC)c3OC)\\N2",
    "HIT":0.0,
    "question":"Does the proposed molecule C(=N\/c(cc1)ccc1C)(\/S\\C(\\C2=O)=C\\c(ccc(c3)N(CC)CC)c3OC)\\N2 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":32602
  },
  {
    "COADD_ID":"CO-ADD:0291249",
    "INHIB_AVE":9.56,
    "SMILES":"N1(Cc2ccccc2)C(=O)\\C(\\SC1=S)=C(\/c3c(N4)ccc(c3)[N+](=O)[O-])\\C4=O",
    "HIT":0.0,
    "question":"Can N1(Cc2ccccc2)C(=O)\\C(\\SC1=S)=C(\/c3c(N4)ccc(c3)[N+](=O)[O-])\\C4=O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":18248
  },
  {
    "COADD_ID":"CO-ADD:0222636",
    "INHIB_AVE":-2.09,
    "SMILES":"[N+](=O)([O-])c(cc(cc1[N+](=O)[O-])C(=O)Oc2c(Br)cc(cc2Br)\\C=N\\c(cc3)ccc3N=Nc4ccccc4)c1",
    "HIT":0.0,
    "question":"Is [N+](=O)([O-])c(cc(cc1[N+](=O)[O-])C(=O)Oc2c(Br)cc(cc2Br)\\C=N\\c(cc3)ccc3N=Nc4ccccc4)c1 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":64646
  },
  {
    "COADD_ID":"CO-ADD:0254315",
    "INHIB_AVE":4.76,
    "SMILES":"c1(SCC(=O)Nc(cc2)ccc2Br)sc3c(ccc(c3)NC(=O)c4ccc(cc4)OCCCCCCCCCC)n1",
    "HIT":0.0,
    "question":"Can c1(SCC(=O)Nc(cc2)ccc2Br)sc3c(ccc(c3)NC(=O)c4ccc(cc4)OCCCCCCCCCC)n1 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":36738
  },
  {
    "COADD_ID":"CO-ADD:0157972",
    "INHIB_AVE":11.38,
    "SMILES":"N#CC1=C(N)OC(N(C2=CC=CC=C2)N=C3C)=C3C1C4=CC=CC(F)=C4",
    "HIT":0.0,
    "question":"Does N#CC1=C(N)OC(N(C2=CC=CC=C2)N=C3C)=C3C1C4=CC=CC(F)=C4 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":13716
  },
  {
    "COADD_ID":"CO-ADD:0300761",
    "INHIB_AVE":29.09,
    "SMILES":"C(=O)(Nc(cc1)ccc1N(C)C)C(NCCCn(ccn2)c2)=O",
    "HIT":0.0,
    "question":"Does C(=O)(Nc(cc1)ccc1N(C)C)C(NCCCn(ccn2)c2)=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":812
  },
  {
    "COADD_ID":"CO-ADD:0227307",
    "INHIB_AVE":6.32,
    "SMILES":"[N+](=O)([O-])c1ccc(cc1\\C=N\\NC(COc(cc2)ccc2C(C)(C)CC(C)(C)C)=O)O",
    "HIT":0.0,
    "question":"Does treatment with [N+](=O)([O-])c1ccc(cc1\\C=N\\NC(COc(cc2)ccc2C(C)(C)CC(C)(C)C)=O)O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":29905
  },
  {
    "COADD_ID":"CO-ADD:0292454",
    "INHIB_AVE":14.03,
    "SMILES":"C1(c2ccccc2)(N3)C(c4ccccc4)(N=C(S\\C(=C\/c(cc(OCO5)c5c6)c6Br)\\C7=O)N37)N(C(=O)N1C)C",
    "HIT":0.0,
    "question":"Does C1(c2ccccc2)(N3)C(c4ccccc4)(N=C(S\\C(=C\/c(cc(OCO5)c5c6)c6Br)\\C7=O)N37)N(C(=O)N1C)C show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":8987
  },
  {
    "COADD_ID":"CO-ADD:0225489",
    "INHIB_AVE":1.59,
    "SMILES":"C1(=N2)N(C=Cn(nc(c3ccc(cc3)OC)c4)c14)C(N2CC(=O)Nc(ccc(c5C)C)c5)=O",
    "HIT":0.0,
    "question":"Does treatment with C1(=N2)N(C=Cn(nc(c3ccc(cc3)OC)c4)c14)C(N2CC(=O)Nc(ccc(c5C)C)c5)=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":50891
  },
  {
    "COADD_ID":"CO-ADD:0331421",
    "INHIB_AVE":-3.44,
    "SMILES":"n1c(c(cc2)ccc2S(C)(=O)=O)nnn1CC(=O)Nc(cc3)ccc3OC(F)(F)Cl",
    "HIT":0.0,
    "question":"Does n1c(c(cc2)ccc2S(C)(=O)=O)nnn1CC(=O)Nc(cc3)ccc3OC(F)(F)Cl demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":68359
  },
  {
    "COADD_ID":"CO-ADD:0156934",
    "INHIB_AVE":6.19,
    "SMILES":"[O-][N+](C1=CC(\/C=N\/C2=C(C3=CC(OC)=C(O)C=C3)N=C4N2C=CC=C4)=CC=C1Cl)=O",
    "HIT":0.0,
    "question":"Does treatment with [O-][N+](C1=CC(\/C=N\/C2=C(C3=CC(OC)=C(O)C=C3)N=C4N2C=CC=C4)=CC=C1Cl)=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":30446
  },
  {
    "COADD_ID":"CO-ADD:0292658",
    "INHIB_AVE":9.46,
    "SMILES":"c1(c(N)ncnc1Nc(cc(C)cc2C)c2)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Can c1(c(N)ncnc1Nc(cc(C)cc2C)c2)[N+](=O)[O-] effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":18546
  },
  {
    "COADD_ID":"CO-ADD:0149652",
    "INHIB_AVE":8.98,
    "SMILES":"NC1=C2C(CCC2)=NC3=C1C(C4=CC(OC)=C(O)C=C4)C(C(OCC)=O)=C(C)O3",
    "HIT":0.0,
    "question":"Can NC1=C2C(CCC2)=NC3=C1C(C4=CC(OC)=C(O)C=C4)C(C(OCC)=O)=C(C)O3 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":19951
  },
  {
    "COADD_ID":"CO-ADD:0249471",
    "INHIB_AVE":-1.38,
    "SMILES":"C(=O)(Nc1cccc(OC)c1)N(C)c2cccc(Cl)c2",
    "HIT":0.0,
    "question":"Can C(=O)(Nc1cccc(OC)c1)N(C)c2cccc(Cl)c2 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":62357
  },
  {
    "COADD_ID":"CO-ADD:0307291",
    "INHIB_AVE":9.3,
    "SMILES":"c1(cc(F)c(cc1N(CC2)CCN2C(=O)c3cccs3)N4CCC(CC4)C)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Can c1(cc(F)c(cc1N(CC2)CCN2C(=O)c3cccs3)N4CCC(CC4)C)[N+](=O)[O-] effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":19035
  },
  {
    "COADD_ID":"CO-ADD:0221791",
    "INHIB_AVE":1.65,
    "SMILES":"c1(ccccc1Br)C(=O)NCC(=O)N\\N=C(\\C)\/Cc2ccccc2",
    "HIT":0.0,
    "question":"Can c1(ccccc1Br)C(=O)NCC(=O)N\\N=C(\\C)\/Cc2ccccc2 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":50647
  },
  {
    "COADD_ID":"CO-ADD:0327321",
    "INHIB_AVE":-3.46,
    "SMILES":"C12(SCC(=O)N1c(cc3)ccc3C(=O)NCc4ccccc4)c5c(NC2=O)cccc5",
    "HIT":0.0,
    "question":"Can C12(SCC(=O)N1c(cc3)ccc3C(=O)NCc4ccccc4)c5c(NC2=O)cccc5 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":68415
  },
  {
    "COADD_ID":"CO-ADD:0165904",
    "INHIB_AVE":-0.56,
    "SMILES":"C(=C(\/C=N\/Nc(cc1)ccc1C(OCC)=O)\\c(cccc2[N+](=O)[O-])c2)(\/C3=O)\\C(=O)N(N3c4ccccc4)c5ccccc5",
    "HIT":0.0,
    "question":"Does the proposed molecule C(=C(\/C=N\/Nc(cc1)ccc1C(OCC)=O)\\c(cccc2[N+](=O)[O-])c2)(\/C3=O)\\C(=O)N(N3c4ccccc4)c5ccccc5 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":59588
  },
  {
    "COADD_ID":"CO-ADD:0283538",
    "INHIB_AVE":-5.88,
    "SMILES":"C(C(=O)OCC(C)C)(=C(C)NC(=C12)CC(CC1=O)c3ccc(cc3)OC)C2c4ccc(c5c4)OCO5",
    "HIT":0.0,
    "question":"Can C(C(=O)OCC(C)C)(=C(C)NC(=C12)CC(CC1=O)c3ccc(cc3)OC)C2c4ccc(c5c4)OCO5 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":73501
  },
  {
    "COADD_ID":"CO-ADD:0259165",
    "INHIB_AVE":1.89,
    "SMILES":"C(=N\/c1ccccc1)(\/SC=C2c3ccc(cc3)Br)\\N2CCCO.Br",
    "HIT":0.0,
    "question":"Does the proposed molecule C(=N\/c1ccccc1)(\/SC=C2c3ccc(cc3)Br)\\N2CCCO.Br exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":49625
  },
  {
    "COADD_ID":"CO-ADD:0254340",
    "INHIB_AVE":9.89,
    "SMILES":"C(CSc1cccc(cccn2)c12)(=O)N\\N=C\\c3ccccc3OC",
    "HIT":0.0,
    "question":"Can exposure to C(CSc1cccc(cccn2)c12)(=O)N\\N=C\\c3ccccc3OC lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":17315
  },
  {
    "COADD_ID":"CO-ADD:0319761",
    "INHIB_AVE":-1.6,
    "SMILES":"C(C(OC)=O)(C(F)(F)F)(NC(=O)c1ccc(cc1)Cl)Nc2sc3c(CCC(C(C)(C)C)C3)c2C#N",
    "HIT":0.0,
    "question":"Does treatment with C(C(OC)=O)(C(F)(F)F)(NC(=O)c1ccc(cc1)Cl)Nc2sc3c(CCC(C(C)(C)C)C3)c2C#N result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":63065
  },
  {
    "COADD_ID":"CO-ADD:0220916",
    "INHIB_AVE":-0.63,
    "SMILES":"c12c(ccc(OC)c1OC)C(OC2=O)Nc3cc(C)ccc3C",
    "HIT":0.0,
    "question":"Is c12c(ccc(OC)c1OC)C(OC2=O)Nc3cc(C)ccc3C capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":59840
  },
  {
    "COADD_ID":"CO-ADD:0218573",
    "INHIB_AVE":11.68,
    "SMILES":"c1(ccccc1\\N=C\/c(ccc(c2OC)OC)c2)c3ccccc3\\N=C\/c(ccc(c4OC)OC)c4",
    "HIT":0.0,
    "question":"Does c1(ccccc1\\N=C\/c(ccc(c2OC)OC)c2)c3ccccc3\\N=C\/c(ccc(c4OC)OC)c4 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":13083
  },
  {
    "COADD_ID":"CO-ADD:0148978",
    "INHIB_AVE":0.16,
    "SMILES":"c1(nc(c2n1CC(=O)Nc(cc3)cc(c34)COC4=O)cccc2)c5nonc5N",
    "HIT":0.0,
    "question":"Does c1(nc(c2n1CC(=O)Nc(cc3)cc(c34)COC4=O)cccc2)c5nonc5N show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":56839
  },
  {
    "COADD_ID":"CO-ADD:0319346",
    "INHIB_AVE":-0.27,
    "SMILES":"c1(C2=O)c(sc(c3cccc(OC)c3)c1)N=C(S)N2c4ccccc4",
    "HIT":0.0,
    "question":"Does c1(C2=O)c(sc(c3cccc(OC)c3)c1)N=C(S)N2c4ccccc4 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":58501
  },
  {
    "COADD_ID":"CO-ADD:0217898",
    "INHIB_AVE":17.8,
    "SMILES":"C(=O)(CN(CC1)CCN1CC(=O)Nc(cc2)ccc2C)Nc(cc3)ccc3C",
    "HIT":0.0,
    "question":"Does the proposed molecule C(=O)(CN(CC1)CCN1CC(=O)Nc(cc2)ccc2C)Nc(cc3)ccc3C exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":4483
  },
  {
    "COADD_ID":"CO-ADD:0231615",
    "INHIB_AVE":3.9,
    "SMILES":"[N+](=O)([O-])c1cc2c(cc1\\C=N\\c(cc3)ccc3I)OCO2",
    "HIT":0.0,
    "question":"Is [N+](=O)([O-])c1cc2c(cc1\\C=N\\c(cc3)ccc3I)OCO2 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":40602
  },
  {
    "COADD_ID":"CO-ADD:0256968",
    "INHIB_AVE":7.76,
    "SMILES":"c1(sc(c(ccc2S(C)(=O)=O)n1)c2)NC(=O)c3cccc(C)c3",
    "HIT":0.0,
    "question":"Can c1(sc(c(ccc2S(C)(=O)=O)n1)c2)NC(=O)c3cccc(C)c3 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":24101
  },
  {
    "COADD_ID":"CO-ADD:0157257",
    "INHIB_AVE":13.87,
    "SMILES":"[O-][N+](C1=CC(C)=CC(C)=C1N\/C=C2C(N(C3=CC=C(Cl)C=C3)N=C\/2C)=O)=O",
    "HIT":0.0,
    "question":"Is [O-][N+](C1=CC(C)=CC(C)=C1N\/C=C2C(N(C3=CC=C(Cl)C=C3)N=C\/2C)=O)=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":9241
  },
  {
    "COADD_ID":"CO-ADD:0214968",
    "INHIB_AVE":11.31,
    "SMILES":"C(=O)(N\\N=C\\c(ccc(c1C)C)c1)C(=O)Nc2ccc(cc2C)Cl",
    "HIT":0.0,
    "question":"Does treatment with C(=O)(N\\N=C\\c(ccc(c1C)C)c1)C(=O)Nc2ccc(cc2C)Cl result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":13880
  },
  {
    "COADD_ID":"CO-ADD:0321020",
    "INHIB_AVE":6.72,
    "SMILES":"c1(c(Cl)ccc(c1)[N+](=O)[O-])C(=O)Nc(ccc(c2O3)OC3(F)F)c2",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(c(Cl)ccc(c1)[N+](=O)[O-])C(=O)Nc(ccc(c2O3)OC3(F)F)c2?",
    "answer":"No",
    "_id":28183
  },
  {
    "COADD_ID":"CO-ADD:0161682",
    "INHIB_AVE":7.02,
    "SMILES":"C(c1ccccc1)(=O)Oc2ccc(cc2OCC)\\C=N\\NC(COc(cc3)ccc3C)=O",
    "HIT":0.0,
    "question":"Can C(c1ccccc1)(=O)Oc2ccc(cc2OCC)\\C=N\\NC(COc(cc3)ccc3C)=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":26920
  },
  {
    "COADD_ID":"CO-ADD:0232693",
    "INHIB_AVE":10.49,
    "SMILES":"N1(c2cccc(C)c2)C(=O)C(CC1=O)S\\C(\\N)=N\\c3ccccc3",
    "HIT":0.0,
    "question":"Is N1(c2cccc(C)c2)C(=O)C(CC1=O)S\\C(\\N)=N\\c3ccccc3 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":15752
  },
  {
    "COADD_ID":"CO-ADD:0328352",
    "INHIB_AVE":-12.18,
    "SMILES":"n1(c2ccccn2)nnnc1c(cc3)ccc3[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Is n1(c2ccccn2)nnnc1c(cc3)ccc3[N+](=O)[O-] capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":80133
  },
  {
    "COADD_ID":"CO-ADD:0306173",
    "INHIB_AVE":6.78,
    "SMILES":"N1C(c2ccc(cc2)OCc3ccccc3F)SCC1C(O)=O",
    "HIT":0.0,
    "question":"Does treatment with N1C(c2ccc(cc2)OCc3ccccc3F)SCC1C(O)=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":27909
  },
  {
    "COADD_ID":"CO-ADD:0219336",
    "INHIB_AVE":16.72,
    "SMILES":"C(\/O)(\\c1ccc(cc1)Cl)=C\/C=N\/c2ccccc2C",
    "HIT":0.0,
    "question":"Is C(\/O)(\\c1ccc(cc1)Cl)=C\/C=N\/c2ccccc2C effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":5558
  },
  {
    "COADD_ID":"CO-ADD:0160153",
    "INHIB_AVE":11.03,
    "SMILES":"O=C(C1=CC=CC2=C1C3=CC=C2)N(C(C(C([N+]([O-])=O)=C4)=CC=C4[N+]([O-])=O)=O)C3=O",
    "HIT":0.0,
    "question":"Is O=C(C1=CC=CC2=C1C3=CC=C2)N(C(C(C([N+]([O-])=O)=C4)=CC=C4[N+]([O-])=O)=O)C3=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":14460
  },
  {
    "COADD_ID":"CO-ADD:0255164",
    "INHIB_AVE":1.04,
    "SMILES":"C(=O)(Nc(cccc1\\C=C\\C(c2ccccc2)=O)c1)c(c3)cc(cc3NC(=O)C(C)(C)C)NC(=O)C(C)(C)C",
    "HIT":0.0,
    "question":"Can exposure to C(=O)(Nc(cccc1\\C=C\\C(c2ccccc2)=O)c1)c(c3)cc(cc3NC(=O)C(C)(C)C)NC(=O)C(C)(C)C lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":53264
  },
  {
    "COADD_ID":"CO-ADD:0319234",
    "INHIB_AVE":-1.77,
    "SMILES":"c1(N(C)C)nc(NCCOC(C2)(C3)CC(CC3CC24)C4)nc(OCC(F)(F)F)n1",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(N(C)C)nc(NCCOC(C2)(C3)CC(CC3CC24)C4)nc(OCC(F)(F)F)n1?",
    "answer":"No",
    "_id":63654
  },
  {
    "COADD_ID":"CO-ADD:0303873",
    "INHIB_AVE":-11.36,
    "SMILES":"N1C(c(cc2OC)cc(c2O)Cl)SCC1C(O)=O",
    "HIT":0.0,
    "question":"Does treatment with N1C(c(cc2OC)cc(c2O)Cl)SCC1C(O)=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":79628
  },
  {
    "COADD_ID":"CO-ADD:0155059",
    "INHIB_AVE":13.8,
    "SMILES":"C(N1C2CCCCC2)(N1)C(N3)N3C4CCCCC4",
    "HIT":0.0,
    "question":"Is C(N1C2CCCCC2)(N1)C(N3)N3C4CCCCC4 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":9341
  },
  {
    "COADD_ID":"CO-ADD:0255969",
    "INHIB_AVE":3.91,
    "SMILES":"N1(c2ccc(c(F)c2)C)C(=O)c(c3C1=O)cccc3",
    "HIT":0.0,
    "question":"Can N1(c2ccc(c(F)c2)C)C(=O)c(c3C1=O)cccc3 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":40568
  },
  {
    "COADD_ID":"CO-ADD:0299298",
    "INHIB_AVE":-6.26,
    "SMILES":"N1(c2ccc(cc2Cl)C)C(=O)c3c(cc(cc3)Br)C1=O",
    "HIT":0.0,
    "question":"Can exposure to N1(c2ccc(cc2Cl)C)C(=O)c3c(cc(cc3)Br)C1=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":74183
  },
  {
    "COADD_ID":"CO-ADD:0326230",
    "INHIB_AVE":12.59,
    "SMILES":"[nH]1c(cccc2)c2c(CCNC(=O)\\C(=C\\c(cc3)ccc3Br)\\NC(c4ccccc4)=O)c1C",
    "HIT":0.0,
    "question":"Does treatment with [nH]1c(cccc2)c2c(CCNC(=O)\\C(=C\\c(cc3)ccc3Br)\\NC(c4ccccc4)=O)c1C result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":11315
  },
  {
    "COADD_ID":"CO-ADD:0234211",
    "INHIB_AVE":3.11,
    "SMILES":"c1(c(Br)cc(cc1\\C=N\\NC(=O)c(c2)cc(cn2)Br)Br)OC(=O)c(ccc(c34)OCO3)c4",
    "HIT":0.0,
    "question":"Does c1(c(Br)cc(cc1\\C=N\\NC(=O)c(c2)cc(cn2)Br)Br)OC(=O)c(ccc(c34)OCO3)c4 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":44128
  },
  {
    "COADD_ID":"CO-ADD:0222789",
    "INHIB_AVE":0.6,
    "SMILES":"C(=O)(Oc(cc1)ccc1\\C=N\\NC(CNC(=O)c(cc2OC)cc(c2OC)OC)=O)c3ccco3",
    "HIT":0.0,
    "question":"Can exposure to C(=O)(Oc(cc1)ccc1\\C=N\\NC(CNC(=O)c(cc2OC)cc(c2OC)OC)=O)c3ccco3 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":55103
  },
  {
    "COADD_ID":"CO-ADD:0319845",
    "INHIB_AVE":3.27,
    "SMILES":"[N+](=O)([O-])c1c(Cl)ccc(c1)C(NCCc(c2c([nH]3)cccc2)c3C)=O",
    "HIT":0.0,
    "question":"Does treatment with [N+](=O)([O-])c1c(Cl)ccc(c1)C(NCCc(c2c([nH]3)cccc2)c3C)=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":43398
  },
  {
    "COADD_ID":"CO-ADD:0155078",
    "INHIB_AVE":0.25,
    "SMILES":"[O-][N+](C1=NC([N+]([O-])=O)=NN1C(CCCC2)C2=O)=O",
    "HIT":0.0,
    "question":"Does [O-][N+](C1=NC([N+]([O-])=O)=NN1C(CCCC2)C2=O)=O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":56471
  },
  {
    "COADD_ID":"CO-ADD:0250228",
    "INHIB_AVE":1.28,
    "SMILES":"S(C)(=O)(=O)N(c1c(C)cccc1C)CC(=O)N\\N=C(\/C2)\\CCCCC2",
    "HIT":0.0,
    "question":"Can S(C)(=O)(=O)N(c1c(C)cccc1C)CC(=O)N\\N=C(\/C2)\\CCCCC2 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":52250
  },
  {
    "COADD_ID":"CO-ADD:0310996",
    "INHIB_AVE":0.03,
    "SMILES":"c1(C(=O)c2ccc(cc2F)F)sc3c(c(COC)cc(C)n3)c1N",
    "HIT":0.0,
    "question":"Can c1(C(=O)c2ccc(cc2F)F)sc3c(c(COC)cc(C)n3)c1N act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":57332
  },
  {
    "COADD_ID":"CO-ADD:0295290",
    "INHIB_AVE":4.44,
    "SMILES":"c1(O2)c(c(n[nH]1)COC)C(C(C#N)=C2N)c(cc3)ccc3C(C)C",
    "HIT":0.0,
    "question":"Does treatment with c1(O2)c(c(n[nH]1)COC)C(C(C#N)=C2N)c(cc3)ccc3C(C)C result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":38173
  },
  {
    "COADD_ID":"CO-ADD:0225483",
    "INHIB_AVE":6.37,
    "SMILES":"C1(=N2)N(C=Cn(nc(c3ccc(cc3)Cl)c4)c14)C(N2CC(=O)Nc(ccc(c56)OCCO5)c6)=O",
    "HIT":0.0,
    "question":"Is C1(=N2)N(C=Cn(nc(c3ccc(cc3)Cl)c4)c14)C(N2CC(=O)Nc(ccc(c56)OCCO5)c6)=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":29683
  },
  {
    "COADD_ID":"CO-ADD:0253238",
    "INHIB_AVE":3.91,
    "SMILES":"S1(=O)(=O)c(cccc2)c2C(Nc3cccc(c3)OC(=O)c4ccc(cc4)Br)=N1",
    "HIT":0.0,
    "question":"Is S1(=O)(=O)c(cccc2)c2C(Nc3cccc(c3)OC(=O)c4ccc(cc4)Br)=N1 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":40554
  },
  {
    "COADD_ID":"CO-ADD:0237250",
    "INHIB_AVE":6.11,
    "SMILES":"NC(=O)c1cc(ccc1OCCOc2ccccc2)c3ccsc3",
    "HIT":0.0,
    "question":"Can NC(=O)c1cc(ccc1OCCOc2ccccc2)c3ccsc3 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":30803
  },
  {
    "COADD_ID":"CO-ADD:0235379",
    "INHIB_AVE":3.72,
    "SMILES":"C(=O)(C(C(C)CC)NC(OCc1ccccc1)=O)Nc2ccc(cc2C)C",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C(=O)(C(C(C)CC)NC(OCc1ccccc1)=O)Nc2ccc(cc2C)C?",
    "answer":"No",
    "_id":41418
  },
  {
    "COADD_ID":"CO-ADD:0257205",
    "INHIB_AVE":-14.42,
    "SMILES":"N1(C(CCCC2=O)=C2C(C(C#N)=C1N)c(ccs3)c3)c4sc(c5c4C(OCC)=O)CCCCC5",
    "HIT":0.0,
    "question":"Is N1(C(CCCC2=O)=C2C(C(C#N)=C1N)c(ccs3)c3)c4sc(c5c4C(OCC)=O)CCCCC5 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":81115
  },
  {
    "COADD_ID":"CO-ADD:0303664",
    "INHIB_AVE":6.84,
    "SMILES":"N1(c2ccc(cc2)O)CC(CC1=O)C(=O)NCC(C)C",
    "HIT":0.0,
    "question":"Does N1(c2ccc(cc2)O)CC(CC1=O)C(=O)NCC(C)C demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":27651
  },
  {
    "COADD_ID":"CO-ADD:0235764",
    "INHIB_AVE":-16.75,
    "SMILES":"C1(=S)NC(C)(C)C=C(C)N1c2ccccc2OC(C)=O",
    "HIT":0.0,
    "question":"Can exposure to C1(=S)NC(C)(C)C=C(C)N1c2ccccc2OC(C)=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":81699
  },
  {
    "COADD_ID":"CO-ADD:0300015",
    "INHIB_AVE":4.56,
    "SMILES":"n1c(N2CC(C)CC(C)C2)c(Nc(ccc(c34)OCO3)c4)nc(non5)c15",
    "HIT":0.0,
    "question":"Can exposure to n1c(N2CC(C)CC(C)C2)c(Nc(ccc(c34)OCO3)c4)nc(non5)c15 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":37653
  },
  {
    "COADD_ID":"CO-ADD:0306977",
    "INHIB_AVE":12.1,
    "SMILES":"C(C#N)(C1c2ccc(cc2)OCc3ccccc3F)=C(N)OC(CC(c4ccco4)CC5=O)=C15",
    "HIT":0.0,
    "question":"Is C(C#N)(C1c2ccc(cc2)OCc3ccccc3F)=C(N)OC(CC(c4ccco4)CC5=O)=C15 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":12251
  },
  {
    "COADD_ID":"CO-ADD:0154546",
    "INHIB_AVE":11.38,
    "SMILES":"O=C(C)C(C(O[C@H]1C[C@H](C)CC[C@H]1C(C)C)=O)=CC2=CC=CC=C2",
    "HIT":0.0,
    "question":"Can exposure to O=C(C)C(C(O[C@H]1C[C@H](C)CC[C@H]1C(C)C)=O)=CC2=CC=CC=C2 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":13726
  },
  {
    "COADD_ID":"CO-ADD:0222058",
    "INHIB_AVE":3.81,
    "SMILES":"c12c(CCCC1[N+](=O)[O-])non2",
    "HIT":0.0,
    "question":"Does treatment with c12c(CCCC1[N+](=O)[O-])non2 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":41046
  },
  {
    "COADD_ID":"CO-ADD:0318941",
    "INHIB_AVE":-1.52,
    "SMILES":"N1(CCC(=O)Nc(cccc2[N+](=O)[O-])c2)C(=O)c(c3C1=O)cccc3",
    "HIT":0.0,
    "question":"Does N1(CCC(=O)Nc(cccc2[N+](=O)[O-])c2)C(=O)c(c3C1=O)cccc3 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":62791
  },
  {
    "COADD_ID":"CO-ADD:0292677",
    "INHIB_AVE":14.09,
    "SMILES":"n1(n2)c(nc(cc1C(F)(F)F)c3ccc(cc3)Cl)cc2C(=O)N4CCCCC4",
    "HIT":0.0,
    "question":"Does n1(n2)c(nc(cc1C(F)(F)F)c3ccc(cc3)Cl)cc2C(=O)N4CCCCC4 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":8877
  },
  {
    "COADD_ID":"CO-ADD:0305720",
    "INHIB_AVE":-1.63,
    "SMILES":"N1(C(c2ccc(cc2)OC)C#N)C(C)(C)CC(C)=N1",
    "HIT":0.0,
    "question":"Can N1(C(c2ccc(cc2)OC)C#N)C(C)(C)CC(C)=N1 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":63171
  },
  {
    "COADD_ID":"CO-ADD:0286844",
    "INHIB_AVE":-0.35,
    "SMILES":"c1(nonc1N)\\C(\\N)=N\\OC(CCCOc2ccc(cc2Cl)Cl)=O",
    "HIT":0.0,
    "question":"Does the proposed molecule c1(nonc1N)\\C(\\N)=N\\OC(CCCOc2ccc(cc2Cl)Cl)=O exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":58810
  },
  {
    "COADD_ID":"CO-ADD:0247621",
    "INHIB_AVE":-4.04,
    "SMILES":"C(NCCOc1cccc(OC)c1)(=O)C(c2ccccc2)c3ccccc3",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C(NCCOc1cccc(OC)c1)(=O)C(c2ccccc2)c3ccccc3?",
    "answer":"No",
    "_id":69857
  },
  {
    "COADD_ID":"CO-ADD:0230717",
    "INHIB_AVE":-8.1,
    "SMILES":"c1(ccccc1Br)C(=O)N\\N=C\\c(cc2)ccc2OCc(cc3)ccc3Cl",
    "HIT":0.0,
    "question":"Is c1(ccccc1Br)C(=O)N\\N=C\\c(cc2)ccc2OCc(cc3)ccc3Cl capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":76838
  },
  {
    "COADD_ID":"CO-ADD:0232965",
    "INHIB_AVE":1.4,
    "SMILES":"c1(c2ccccc2C#N)nnn(CC(=O)N\\N=C\\c(cc(Br)cc3Br)c3O)n1",
    "HIT":0.0,
    "question":"Does c1(c2ccccc2C#N)nnn(CC(=O)N\\N=C\\c(cc(Br)cc3Br)c3O)n1 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":51720
  },
  {
    "COADD_ID":"CO-ADD:0292180",
    "INHIB_AVE":-3.0,
    "SMILES":"c1(NC(=O)\\C=C\\c(cc2)ccc2C(C)C)sc(c3c1C(OCC)=O)CCCC3",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(NC(=O)\\C=C\\c(cc2)ccc2C(C)C)sc(c3c1C(OCC)=O)CCCC3?",
    "answer":"No",
    "_id":67242
  },
  {
    "COADD_ID":"CO-ADD:0149011",
    "INHIB_AVE":6.87,
    "SMILES":"c(cc(c1c2)nc(n1Cc3c(Br)cc(OCO4)c4c3)c(n5)c(N)no5)c2",
    "HIT":0.0,
    "question":"Does c(cc(c1c2)nc(n1Cc3c(Br)cc(OCO4)c4c3)c(n5)c(N)no5)c2 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":27503
  },
  {
    "COADD_ID":"CO-ADD:0250005",
    "INHIB_AVE":7.75,
    "SMILES":"n1(C(=O)\\C=C\\c2ccccc2)c3c(cc1c4ccccc4)cccc3",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound n1(C(=O)\\C=C\\c2ccccc2)c3c(cc1c4ccccc4)cccc3?",
    "answer":"No",
    "_id":24142
  },
  {
    "COADD_ID":"CO-ADD:0229448",
    "INHIB_AVE":1.58,
    "SMILES":"C(=O)(CCOc1ccccc1C)Nc(ccc(c2Cl)Cl)c2",
    "HIT":0.0,
    "question":"Does treatment with C(=O)(CCOc1ccccc1C)Nc(ccc(c2Cl)Cl)c2 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":50917
  },
  {
    "COADD_ID":"CO-ADD:0259845",
    "INHIB_AVE":-4.25,
    "SMILES":"N1(C(C)(C)C)C(=O)c(c2C1=O)ccc(c2)C(=O)Nc(cc3)ccc3C(O)=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound N1(C(C)(C)C)C(=O)c(c2C1=O)ccc(c2)C(=O)Nc(cc3)ccc3C(O)=O?",
    "answer":"No",
    "_id":70330
  },
  {
    "COADD_ID":"CO-ADD:0307578",
    "INHIB_AVE":-6.63,
    "SMILES":"C(\/C#N)(=C\/c1ccc(C)o1)\\C(=O)Nc2c(Cl)ccc(Cl)c2",
    "HIT":0.0,
    "question":"Can C(\/C#N)(=C\/c1ccc(C)o1)\\C(=O)Nc2c(Cl)ccc(Cl)c2 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":74789
  },
  {
    "COADD_ID":"CO-ADD:0254607",
    "INHIB_AVE":-22.26,
    "SMILES":"N1(C2c3ccc(c(OC)c3)OC)C(S\\C(=C\\c(ccc(c4OC)OCc5cccc(cccc6)c56)c4)\\C1=O)=NC(C)=C2C(OCC)=O",
    "HIT":0.0,
    "question":"Does treatment with N1(C2c3ccc(c(OC)c3)OC)C(S\\C(=C\\c(ccc(c4OC)OCc5cccc(cccc6)c56)c4)\\C1=O)=NC(C)=C2C(OCC)=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":82332
  },
  {
    "COADD_ID":"CO-ADD:0222488",
    "INHIB_AVE":-0.65,
    "SMILES":"c1(ccccc1I)C(NCCCN(CC2)CCO2)=O.Cl",
    "HIT":0.0,
    "question":"Does the proposed molecule c1(ccccc1I)C(NCCCN(CC2)CCO2)=O.Cl exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":59905
  },
  {
    "COADD_ID":"CO-ADD:0258841",
    "INHIB_AVE":2.52,
    "SMILES":"c1(\\C=N\\NC(CCCC(=O)NC2CCCCC2)=O)c(O)ccc(cccc3)c13",
    "HIT":0.0,
    "question":"Can c1(\\C=N\\NC(CCCC(=O)NC2CCCCC2)=O)c(O)ccc(cccc3)c13 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":46767
  },
  {
    "COADD_ID":"CO-ADD:0257867",
    "INHIB_AVE":13.01,
    "SMILES":"N1(c2ccccc2)\\C(=N\\c3ccccc3)\\S\\C(=C\\c(ccc4c5c(OC)ccc(c5)[N+](=O)[O-])o4)\\C1=O",
    "HIT":0.0,
    "question":"Is N1(c2ccccc2)\\C(=N\\c3ccccc3)\\S\\C(=C\\c(ccc4c5c(OC)ccc(c5)[N+](=O)[O-])o4)\\C1=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":10554
  },
  {
    "COADD_ID":"CO-ADD:0323842",
    "INHIB_AVE":-3.14,
    "SMILES":"N(CCN1S(c2ccccc2)(=O)=O)(C1c(cc3)cc(c3OS(c4ccccc4)(=O)=O)OC)S(=O)(=O)c5ccc(cc5)C",
    "HIT":0.0,
    "question":"Can N(CCN1S(c2ccccc2)(=O)=O)(C1c(cc3)cc(c3OS(c4ccccc4)(=O)=O)OC)S(=O)(=O)c5ccc(cc5)C effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":67624
  },
  {
    "COADD_ID":"CO-ADD:0295055",
    "INHIB_AVE":-18.6,
    "SMILES":"c1(c[nH]nc1c2ccccc2)c(c3)nc(c4c3C(O)=O)ccc(cccc5)c45",
    "HIT":0.0,
    "question":"Is c1(c[nH]nc1c2ccccc2)c(c3)nc(c4c3C(O)=O)ccc(cccc5)c45 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":81992
  },
  {
    "COADD_ID":"CO-ADD:0330946",
    "INHIB_AVE":6.61,
    "SMILES":"c1(C#N)c(C)cc(nc1SCC(=O)Nc2cccc(cccc3)c23)C",
    "HIT":0.0,
    "question":"Can c1(C#N)c(C)cc(nc1SCC(=O)Nc2cccc(cccc3)c23)C effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":28673
  },
  {
    "COADD_ID":"CO-ADD:0290776",
    "INHIB_AVE":6.02,
    "SMILES":"N1(CC=C)C(=O)\\C(\\SC1=S)=C\/c2cccc(C)n2",
    "HIT":0.0,
    "question":"Is N1(CC=C)C(=O)\\C(\\SC1=S)=C\/c2cccc(C)n2 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":31187
  },
  {
    "COADD_ID":"CO-ADD:0300885",
    "INHIB_AVE":12.8,
    "SMILES":"c1(ccc(cc1N(CC2)CCO2)N(CC3)CCN3C(=O)c4ccc(cc4)Cl)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Can c1(ccc(cc1N(CC2)CCO2)N(CC3)CCN3C(=O)c4ccc(cc4)Cl)[N+](=O)[O-] effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":10938
  },
  {
    "COADD_ID":"CO-ADD:0260161",
    "INHIB_AVE":1.92,
    "SMILES":"n1c[nH]nc1SCC(=O)Nc2c(C)cccc2C",
    "HIT":0.0,
    "question":"Does the proposed molecule n1c[nH]nc1SCC(=O)Nc2c(C)cccc2C exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":49461
  },
  {
    "COADD_ID":"CO-ADD:0226773",
    "INHIB_AVE":14.76,
    "SMILES":"c1(C2=O)n(c(nn1)CCC)c3c(cccc3)N2CC(=O)Nc(cc4)ccc4Br",
    "HIT":0.0,
    "question":"Is c1(C2=O)n(c(nn1)CCC)c3c(cccc3)N2CC(=O)Nc(cc4)ccc4Br effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":7911
  },
  {
    "COADD_ID":"CO-ADD:0236142",
    "INHIB_AVE":3.85,
    "SMILES":"C(C#N)(C1c2ccc(c(OC)c2)OC)=C(N)N(C(CCCC3=O)=C13)c4ccc(cc4)Br",
    "HIT":0.0,
    "question":"Is C(C#N)(C1c2ccc(c(OC)c2)OC)=C(N)N(C(CCCC3=O)=C13)c4ccc(cc4)Br capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":40850
  },
  {
    "COADD_ID":"CO-ADD:0287369",
    "INHIB_AVE":9.58,
    "SMILES":"N1(c2ccc(cc2)OCC)C(=O)CC(N(Cc3ccco3)C(=O)c4ccc(cc4)Cl)C1=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound N1(c2ccc(cc2)OCC)C(=O)CC(N(Cc3ccco3)C(=O)c4ccc(cc4)Cl)C1=O?",
    "answer":"No",
    "_id":18185
  },
  {
    "COADD_ID":"CO-ADD:0288864",
    "INHIB_AVE":-0.14,
    "SMILES":"Cc(n(c(c1)C)CCC)n1",
    "HIT":0.0,
    "question":"Is Cc(n(c(c1)C)CCC)n1 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":58036
  },
  {
    "COADD_ID":"CO-ADD:0300358",
    "INHIB_AVE":12.68,
    "SMILES":"n1(c(cc2)ccc2C(OC)=O)nnnc1SCC(=O)Nc3ccccc3CC",
    "HIT":0.0,
    "question":"Does the proposed molecule n1(c(cc2)ccc2C(OC)=O)nnnc1SCC(=O)Nc3ccccc3CC exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":11163
  },
  {
    "COADD_ID":"CO-ADD:0148712",
    "INHIB_AVE":8.97,
    "SMILES":"c1(n[nH]cc1c2ccc(cc2)OC)c3ccc(cc3O)OC",
    "HIT":0.0,
    "question":"Does c1(n[nH]cc1c2ccc(cc2)OC)c3ccc(cc3O)OC show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":19978
  },
  {
    "COADD_ID":"CO-ADD:0257056",
    "INHIB_AVE":-3.87,
    "SMILES":"N(N(c1ccc(cc1)Br)CC2C(OC)=O)=C2C(C)=O",
    "HIT":0.0,
    "question":"Does treatment with N(N(c1ccc(cc1)Br)CC2C(OC)=O)=C2C(C)=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":69449
  },
  {
    "COADD_ID":"CO-ADD:0323516",
    "INHIB_AVE":20.93,
    "SMILES":"n1(c2c(nc1)cccc2)C(=O)c3ccc(c(OC)c3)OCc(cc4)ccc4Cl",
    "HIT":0.0,
    "question":"Can n1(c2c(nc1)cccc2)C(=O)c3ccc(c(OC)c3)OCc(cc4)ccc4Cl effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":2374
  },
  {
    "COADD_ID":"CO-ADD:0156184",
    "INHIB_AVE":6.99,
    "SMILES":"O=C(COC(C=C1)=CC=C1OCCCCCCCC)N\/N=C\/C2=C(O)C=CC3=C2C=CC=C3",
    "HIT":0.0,
    "question":"Does the proposed molecule O=C(COC(C=C1)=CC=C1OCCCCCCCC)N\/N=C\/C2=C(O)C=CC3=C2C=CC=C3 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":27048
  },
  {
    "COADD_ID":"CO-ADD:0156040",
    "INHIB_AVE":-0.83,
    "SMILES":"[O-][N+](C1=CC=CC=C1\/C=C\/C=N\/C2=CC=C(C=C2)C3=NC4=CC=CC=C4N3)=O",
    "HIT":0.0,
    "question":"Is [O-][N+](C1=CC=CC=C1\/C=C\/C=N\/C2=CC=C(C=C2)C3=NC4=CC=CC=C4N3)=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":60549
  },
  {
    "COADD_ID":"CO-ADD:0286676",
    "INHIB_AVE":-2.81,
    "SMILES":"c1(c2c(sc1NC(=O)c3cccc(C)c3)CCCCC2)C(=O)N4CCCCC4",
    "HIT":0.0,
    "question":"Can c1(c2c(sc1NC(=O)c3cccc(C)c3)CCCCC2)C(=O)N4CCCCC4 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":66709
  },
  {
    "COADD_ID":"CO-ADD:0242683",
    "INHIB_AVE":-5.5,
    "SMILES":"S(=O)(=O)(c1ccc(cc1)CC)Oc2c(Br)cc(c(cccn3)c23)Br",
    "HIT":0.0,
    "question":"Can S(=O)(=O)(c1ccc(cc1)CC)Oc2c(Br)cc(c(cccn3)c23)Br act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":72851
  },
  {
    "COADD_ID":"CO-ADD:0163278",
    "INHIB_AVE":8.89,
    "SMILES":"C(CNc(cc1)ccc1C)(=O)N\\N=C\\c2cccc(cccc3)c23",
    "HIT":0.0,
    "question":"Does treatment with C(CNc(cc1)ccc1C)(=O)N\\N=C\\c2cccc(cccc3)c23 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":20237
  },
  {
    "COADD_ID":"CO-ADD:0215543",
    "INHIB_AVE":9.8,
    "SMILES":"C(=O)(N\\N=C\\c(ccc(c1OCC)OCc(cc2)ccc2Cl)c1)C(=O)Nc(cccc3C(F)(F)F)c3",
    "HIT":0.0,
    "question":"Can C(=O)(N\\N=C\\c(ccc(c1OCC)OCc(cc2)ccc2Cl)c1)C(=O)Nc(cccc3C(F)(F)F)c3 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":17572
  },
  {
    "COADD_ID":"CO-ADD:0331160",
    "INHIB_AVE":-3.42,
    "SMILES":"n1(c2c(n3)cccc2)c3CSCC(O)C1",
    "HIT":0.0,
    "question":"Can n1(c2c(n3)cccc2)c3CSCC(O)C1 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":68288
  },
  {
    "COADD_ID":"CO-ADD:0279033",
    "INHIB_AVE":-2.65,
    "SMILES":"C(\/C(OCC)=O)(=C\\Nc1ccccc1)\\[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Can exposure to C(\/C(OCC)=O)(=C\\Nc1ccccc1)\\[N+](=O)[O-] lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":66237
  },
  {
    "COADD_ID":"CO-ADD:0331162",
    "INHIB_AVE":13.94,
    "SMILES":"c1(COc2ccccc2)nc(c3n1C(C)C)cccc3",
    "HIT":0.0,
    "question":"Does c1(COc2ccccc2)nc(c3n1C(C)C)cccc3 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":9134
  },
  {
    "COADD_ID":"CO-ADD:0277516",
    "INHIB_AVE":1.95,
    "SMILES":"C(=O)(NC(C)C)C(=O)NCc1ccccc1Cl",
    "HIT":0.0,
    "question":"Does the proposed molecule C(=O)(NC(C)C)C(=O)NCc1ccccc1Cl exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":49339
  },
  {
    "COADD_ID":"CO-ADD:0292666",
    "INHIB_AVE":-6.11,
    "SMILES":"n12c(nc(cc1C(F)(F)F)c3ccc(cc3)Cl)cc(C(NCCC)=O)n2",
    "HIT":0.0,
    "question":"Can n12c(nc(cc1C(F)(F)F)c3ccc(cc3)Cl)cc(C(NCCC)=O)n2 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":73941
  },
  {
    "COADD_ID":"CO-ADD:0323858",
    "INHIB_AVE":-1.74,
    "SMILES":"S(=O)(=O)(N(CC1)CCN1C23CC4CC(CC(C4)C2)C3)c5c(OC)ccc(Cl)c5",
    "HIT":0.0,
    "question":"Does treatment with S(=O)(=O)(N(CC1)CCN1C23CC4CC(CC(C4)C2)C3)c5c(OC)ccc(Cl)c5 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":63557
  },
  {
    "COADD_ID":"CO-ADD:0164455",
    "INHIB_AVE":17.79,
    "SMILES":"NC(Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(O)=O",
    "HIT":0.0,
    "question":"Can NC(Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(O)=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":4494
  },
  {
    "COADD_ID":"CO-ADD:0222374",
    "INHIB_AVE":3.87,
    "SMILES":"c1(N(CC2)CCO2)nc(N\\N=C\/c3cc(OCO4)c4cc3[N+](=O)[O-])nc(Nc(cc5)ccc5[N+](=O)[O-])n1",
    "HIT":0.0,
    "question":"Does treatment with c1(N(CC2)CCO2)nc(N\\N=C\/c3cc(OCO4)c4cc3[N+](=O)[O-])nc(Nc(cc5)ccc5[N+](=O)[O-])n1 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":40773
  },
  {
    "COADD_ID":"CO-ADD:0306762",
    "INHIB_AVE":3.2,
    "SMILES":"C(C(=O)OC(C)CC)(C1c2ccc(cc2)SC)=C(C)NC(CCCC3=O)=C13",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C(C(=O)OC(C)CC)(C1c2ccc(cc2)SC)=C(C)NC(CCCC3=O)=C13?",
    "answer":"No",
    "_id":43722
  },
  {
    "COADD_ID":"CO-ADD:0245434",
    "INHIB_AVE":25.2,
    "SMILES":"c1(nc(c2n1CC(=O)N\\N=C\\c3cc(Br)cc(Br)c3OCc4ccc(cc4Cl)Cl)cccc2)c5nonc5N",
    "HIT":0.0,
    "question":"Can c1(nc(c2n1CC(=O)N\\N=C\\c3cc(Br)cc(Br)c3OCc4ccc(cc4Cl)Cl)cccc2)c5nonc5N act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":1146
  },
  {
    "COADD_ID":"CO-ADD:0161493",
    "INHIB_AVE":4.18,
    "SMILES":"c1(S(CC)(=O)=O)c(C(OC)=O)n2c(ccc(C(N)=O)c2)c1S(CC)(=O)=O",
    "HIT":0.0,
    "question":"Does treatment with c1(S(CC)(=O)=O)c(C(OC)=O)n2c(ccc(C(N)=O)c2)c1S(CC)(=O)=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":39345
  },
  {
    "COADD_ID":"CO-ADD:0324380",
    "INHIB_AVE":5.9,
    "SMILES":"c12c(CCNC1c(cc3)ccc3N(CC)CC)cc(c(OCC)c2)OCC",
    "HIT":0.0,
    "question":"Does c12c(CCNC1c(cc3)ccc3N(CC)CC)cc(c(OCC)c2)OCC show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":31693
  },
  {
    "COADD_ID":"CO-ADD:0219563",
    "INHIB_AVE":9.81,
    "SMILES":"c1(\\C=N\\NCc(cc2)ccc2Cl)c3c(cccc3)cc(cccc4)c14",
    "HIT":0.0,
    "question":"Can c1(\\C=N\\NCc(cc2)ccc2Cl)c3c(cccc3)cc(cccc4)c14 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":17543
  },
  {
    "COADD_ID":"CO-ADD:0229694",
    "INHIB_AVE":0.49,
    "SMILES":"C(CNc1cccc(Br)c1)(=O)N\\N=C\\c2cccs2",
    "HIT":0.0,
    "question":"Is C(CNc1cccc(Br)c1)(=O)N\\N=C\\c2cccs2 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":55521
  },
  {
    "COADD_ID":"CO-ADD:0311084",
    "INHIB_AVE":-11.84,
    "SMILES":"C12(CC3CC(CC(C3)C1)C2)c(cc4)ccc4C(=O)NC(C(C)C)C(O)=O",
    "HIT":0.0,
    "question":"Does C12(CC3CC(CC(C3)C1)C2)c(cc4)ccc4C(=O)NC(C(C)C)C(O)=O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":79933
  },
  {
    "COADD_ID":"CO-ADD:0221912",
    "INHIB_AVE":5.1,
    "SMILES":"N1(c2cccc(Cl)c2)C(=O)\\C(\\C(C)=N1)=C\\NNC(=O)c3ccc(cc3)O",
    "HIT":0.0,
    "question":"Does N1(c2cccc(Cl)c2)C(=O)\\C(\\C(C)=N1)=C\\NNC(=O)c3ccc(cc3)O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":35191
  },
  {
    "COADD_ID":"CO-ADD:0250441",
    "INHIB_AVE":-2.52,
    "SMILES":"n1c(c2ccc(cc2)OCc3c(cccc3F)Cl)[nH]c(c4ccccc4)c1c5ccccc5",
    "HIT":0.0,
    "question":"Is n1c(c2ccc(cc2)OCc3c(cccc3F)Cl)[nH]c(c4ccccc4)c1c5ccccc5 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":65860
  },
  {
    "COADD_ID":"CO-ADD:0291077",
    "INHIB_AVE":-10.62,
    "SMILES":"N1(CN(Cc2ccccc2OC)CN3C(=O)c(c4C3=O)cccc4)C(=O)c(c5C1=O)cccc5",
    "HIT":0.0,
    "question":"Can N1(CN(Cc2ccccc2OC)CN3C(=O)c(c4C3=O)cccc4)C(=O)c(c5C1=O)cccc5 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":79155
  },
  {
    "COADD_ID":"CO-ADD:0319853",
    "INHIB_AVE":2.14,
    "SMILES":"c1(C#N)c(c2ccccc2)cc(nc1SCC(=O)Nc(cc(cc3C(F)(F)F)C(F)(F)F)c3)c4ccccc4",
    "HIT":0.0,
    "question":"Does the proposed molecule c1(C#N)c(c2ccccc2)cc(nc1SCC(=O)Nc(cc(cc3C(F)(F)F)C(F)(F)F)c3)c4ccccc4 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":48434
  },
  {
    "COADD_ID":"CO-ADD:0223378",
    "INHIB_AVE":7.53,
    "SMILES":"C(CCC(NCCc1ccccc1)=O)(=O)[O-].[K+]",
    "HIT":0.0,
    "question":"Does C(CCC(NCCc1ccccc1)=O)(=O)[O-].[K+] demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":24957
  },
  {
    "COADD_ID":"CO-ADD:0162009",
    "INHIB_AVE":15.75,
    "SMILES":"c1(ccc(cc1Cl)Cl)C(=O)N\\N=C\\c(ccc2Sc3cccc(cccn4)c34)o2",
    "HIT":0.0,
    "question":"Is c1(ccc(cc1Cl)Cl)C(=O)N\\N=C\\c(ccc2Sc3cccc(cccn4)c34)o2 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":6648
  },
  {
    "COADD_ID":"CO-ADD:0295343",
    "INHIB_AVE":-6.35,
    "SMILES":"c1(cc(Br)ccc1OCc2ccccc2Cl)C(OCC)=O",
    "HIT":0.0,
    "question":"Does the proposed molecule c1(cc(Br)ccc1OCc2ccccc2Cl)C(OCC)=O exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":74334
  },
  {
    "COADD_ID":"CO-ADD:0227424",
    "INHIB_AVE":8.39,
    "SMILES":"c1(NCC(=O)N\\N=C\\c(cc2)ccc2OC)c(Br)cc(cc1Br)Br",
    "HIT":0.0,
    "question":"Does the proposed molecule c1(NCC(=O)N\\N=C\\c(cc2)ccc2OC)c(Br)cc(cc1Br)Br exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":21818
  },
  {
    "COADD_ID":"CO-ADD:0332071",
    "INHIB_AVE":13.93,
    "SMILES":"C1(=Cc2c(OC1=O)ccc(Br)c2)C(=O)NC(c(cccc3[N+](=O)[O-])c3)CC(OCC)=O",
    "HIT":0.0,
    "question":"Can exposure to C1(=Cc2c(OC1=O)ccc(Br)c2)C(=O)NC(c(cccc3[N+](=O)[O-])c3)CC(OCC)=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":9154
  },
  {
    "COADD_ID":"CO-ADD:0318698",
    "INHIB_AVE":3.29,
    "SMILES":"C12(c3c(N(CC)C1=O)cccc3)C(C#N)=C(N)OC(C=C(C)OC4=O)=C24",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C12(c3c(N(CC)C1=O)cccc3)C(C#N)=C(N)OC(C=C(C)OC4=O)=C24?",
    "answer":"No",
    "_id":43300
  },
  {
    "COADD_ID":"CO-ADD:0158659",
    "INHIB_AVE":3.68,
    "SMILES":"O=C(NCCNC(C(C1=CC=CC=C1)C2=CC=CC=C2)=O)C(C3=CC=CC=C3)C4=CC=CC=C4",
    "HIT":0.0,
    "question":"Does treatment with O=C(NCCNC(C(C1=CC=CC=C1)C2=CC=CC=C2)=O)C(C3=CC=CC=C3)C4=CC=CC=C4 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":41583
  },
  {
    "COADD_ID":"CO-ADD:0217486",
    "INHIB_AVE":10.49,
    "SMILES":"N(\\C(=C\/c(cc1)cc(c1OC(C)=O)OCC)\\C(O2)=O)=C2c(cc3)ccc3C(C)(C)C",
    "HIT":0.0,
    "question":"Does N(\\C(=C\/c(cc1)cc(c1OC(C)=O)OCC)\\C(O2)=O)=C2c(cc3)ccc3C(C)(C)C show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":15774
  },
  {
    "COADD_ID":"CO-ADD:0155956",
    "INHIB_AVE":-5.32,
    "SMILES":"CC1=C(C2=CC=CC=C2C=C1)CSC3=NC(C4=CC=CC=C4)=CN3",
    "HIT":0.0,
    "question":"Is CC1=C(C2=CC=CC=C2C=C1)CSC3=NC(C4=CC=CC=C4)=CN3 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":72497
  },
  {
    "COADD_ID":"CO-ADD:0292215",
    "INHIB_AVE":0.56,
    "SMILES":"c1(NC(=O)c(cc2OC)cc(c2OC)OC)sc(c3c1C(N)=O)CCC3",
    "HIT":0.0,
    "question":"Is c1(NC(=O)c(cc2OC)cc(c2OC)OC)sc(c3c1C(N)=O)CCC3 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":55279
  },
  {
    "COADD_ID":"CO-ADD:0220351",
    "INHIB_AVE":5.03,
    "SMILES":"c1([nH]c(c2n1)cccc2)c3cc(ccc3O)\\N=C\/c(cc(Br)cc4Br)c4O",
    "HIT":0.0,
    "question":"Does c1([nH]c(c2n1)cccc2)c3cc(ccc3O)\\N=C\/c(cc(Br)cc4Br)c4O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":35498
  },
  {
    "COADD_ID":"CO-ADD:0301639",
    "INHIB_AVE":2.26,
    "SMILES":"C1(C(OCCc2ccccc2)=O)=C(C)NC(=O)CC1c(cccc3[N+](=O)[O-])c3",
    "HIT":0.0,
    "question":"Can C1(C(OCCc2ccccc2)=O)=C(C)NC(=O)CC1c(cccc3[N+](=O)[O-])c3 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":47952
  },
  {
    "COADD_ID":"CO-ADD:0318854",
    "INHIB_AVE":-1.67,
    "SMILES":"c1(C2c(cc3OC)cc(c3OC)OC)c([nH]nc1c4cccs4)OC(N)=C2C#N",
    "HIT":0.0,
    "question":"Can exposure to c1(C2c(cc3OC)cc(c3OC)OC)c([nH]nc1c4cccs4)OC(N)=C2C#N lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":63318
  },
  {
    "COADD_ID":"CO-ADD:0162213",
    "INHIB_AVE":6.96,
    "SMILES":"c1(N2CCCC2)nc(N\\N=C\\c(cc3)ccc3Cl)nc(Nc(cc4)ccc4[N+](=O)[O-])n1",
    "HIT":0.0,
    "question":"Can c1(N2CCCC2)nc(N\\N=C\\c(cc3)ccc3Cl)nc(Nc(cc4)ccc4[N+](=O)[O-])n1 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":27165
  },
  {
    "COADD_ID":"CO-ADD:0319091",
    "INHIB_AVE":-0.28,
    "SMILES":"c1(cccc(cccc2)c12)C(NCCOc3cc(C)ccc3C(C)C)=O",
    "HIT":0.0,
    "question":"Is c1(cccc(cccc2)c12)C(NCCOc3cc(C)ccc3C(C)C)=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":58546
  },
  {
    "COADD_ID":"CO-ADD:0299756",
    "INHIB_AVE":9.46,
    "SMILES":"S(=O)(=O)(c1ccc(cc1)NC(=O)c(cc2OC)cc(c2OC)OC)N3CCCCC3C",
    "HIT":0.0,
    "question":"Does S(=O)(=O)(c1ccc(cc1)NC(=O)c(cc2OC)cc(c2OC)OC)N3CCCCC3C show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":18534
  },
  {
    "COADD_ID":"CO-ADD:0277364",
    "INHIB_AVE":9.88,
    "SMILES":"C(\/C#N)(=C\/c(ccc1c(ccc(c2C(O)=O)Cl)c2)o1)\\C(=O)Nc(ccc(c3C)C)c3",
    "HIT":0.0,
    "question":"Can C(\/C#N)(=C\/c(ccc1c(ccc(c2C(O)=O)Cl)c2)o1)\\C(=O)Nc(ccc(c3C)C)c3 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":17336
  },
  {
    "COADD_ID":"CO-ADD:0219736",
    "INHIB_AVE":-0.6,
    "SMILES":"c1(C(O)=O)cc(ccc1NC(c2ccccc2)=O)c(ccc(c3C(O)=O)NC(c4ccccc4)=O)c3",
    "HIT":0.0,
    "question":"Can c1(C(O)=O)cc(ccc1NC(c2ccccc2)=O)c(ccc(c3C(O)=O)NC(c4ccccc4)=O)c3 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":59734
  },
  {
    "COADD_ID":"CO-ADD:0292870",
    "INHIB_AVE":-8.94,
    "SMILES":"c1(OC)c(OC)cc(cc1OC)CNC(C2CCCC2)=O",
    "HIT":0.0,
    "question":"Can c1(OC)c(OC)cc(cc1OC)CNC(C2CCCC2)=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":77799
  },
  {
    "COADD_ID":"CO-ADD:0228368",
    "INHIB_AVE":4.81,
    "SMILES":"c1(oc2c(ccc(C)c2)n1)c3cc(ccc3O)\\N=C\\c(cc4)ccc4C(=O)Oc5c(Cl)ccc(Cl)c5",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(oc2c(ccc(C)c2)n1)c3cc(ccc3O)\\N=C\\c(cc4)ccc4C(=O)Oc5c(Cl)ccc(Cl)c5?",
    "answer":"No",
    "_id":36505
  },
  {
    "COADD_ID":"CO-ADD:0320248",
    "INHIB_AVE":1.13,
    "SMILES":"C1(c2ccccc2)(c3ccccc3)c4c(cccc4)NC(C5CCCCC5)O1",
    "HIT":0.0,
    "question":"Does C1(c2ccccc2)(c3ccccc3)c4c(cccc4)NC(C5CCCCC5)O1 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":52955
  },
  {
    "COADD_ID":"CO-ADD:0255599",
    "INHIB_AVE":-1.37,
    "SMILES":"C(=O)(c1ccccc1F)NC(c2ccccc2)C(=O)Nc3cccc(Cl)c3",
    "HIT":0.0,
    "question":"Can C(=O)(c1ccccc1F)NC(c2ccccc2)C(=O)Nc3cccc(Cl)c3 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":62300
  },
  {
    "COADD_ID":"CO-ADD:0161843",
    "INHIB_AVE":15.64,
    "SMILES":"c(Nc1ccccc1C)(nc(N\\N=C\\c2ccccc2)nc3Nc(cc4)ccc4[N+](=O)[O-])n3",
    "HIT":0.0,
    "question":"Does c(Nc1ccccc1C)(nc(N\\N=C\\c2ccccc2)nc3Nc(cc4)ccc4[N+](=O)[O-])n3 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":6775
  },
  {
    "COADD_ID":"CO-ADD:0236288",
    "INHIB_AVE":1.59,
    "SMILES":"c(c(Cl)cc(c1\\N=C\\c2ccccc2F)Cl)(NC(C)=O)c1",
    "HIT":0.0,
    "question":"Does the proposed molecule c(c(Cl)cc(c1\\N=C\\c2ccccc2F)Cl)(NC(C)=O)c1 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":50906
  },
  {
    "COADD_ID":"CO-ADD:0245987",
    "INHIB_AVE":7.87,
    "SMILES":"c1(S(CCC)(=O)=O)c(C(=O)N\\N=C\\c(cc2)ccn2)n3c(cccc3)c1S(CCC)(=O)=O",
    "HIT":0.0,
    "question":"Is c1(S(CCC)(=O)=O)c(C(=O)N\\N=C\\c(cc2)ccn2)n3c(cccc3)c1S(CCC)(=O)=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":23670
  },
  {
    "COADD_ID":"CO-ADD:0160246",
    "INHIB_AVE":-0.87,
    "SMILES":"[O-][N+](C1=C(SCC(N)=O)NC(C)=N1)=O",
    "HIT":0.0,
    "question":"Can [O-][N+](C1=C(SCC(N)=O)NC(C)=N1)=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":60679
  },
  {
    "COADD_ID":"CO-ADD:0323399",
    "INHIB_AVE":18.3,
    "SMILES":"N1(C(=O)Cn(nnc2c3ccccc3C)n2)c4c(C(CN(C)CC5)C15)cc(C)cc4",
    "HIT":0.0,
    "question":"Does the proposed molecule N1(C(=O)Cn(nnc2c3ccccc3C)n2)c4c(C(CN(C)CC5)C15)cc(C)cc4 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":4063
  },
  {
    "COADD_ID":"CO-ADD:0229984",
    "INHIB_AVE":-17.05,
    "SMILES":"C(F)(F)(Oc1ccccc1NC(=O)Nc2cccc(cccc3)c23)C(F)C(F)(F)F",
    "HIT":0.0,
    "question":"Does treatment with C(F)(F)(Oc1ccccc1NC(=O)Nc2cccc(cccc3)c23)C(F)C(F)(F)F result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":81754
  },
  {
    "COADD_ID":"CO-ADD:0242137",
    "INHIB_AVE":17.47,
    "SMILES":"c1(NC(=O)c2ccc(cc2)NC(=O)C(F)(F)F)sc(c3c1C(N)=O)CCCC3",
    "HIT":0.0,
    "question":"Can c1(NC(=O)c2ccc(cc2)NC(=O)C(F)(F)F)sc(c3c1C(N)=O)CCCC3 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":4816
  },
  {
    "COADD_ID":"CO-ADD:0302413",
    "INHIB_AVE":-6.63,
    "SMILES":"N1(c2ccccc2OC)C(c(cc3)ccn3)Nc(c4C1=O)cccc4",
    "HIT":0.0,
    "question":"Is N1(c2ccccc2OC)C(c(cc3)ccn3)Nc(c4C1=O)cccc4 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":74781
  },
  {
    "COADD_ID":"CO-ADD:0284070",
    "INHIB_AVE":13.19,
    "SMILES":"C(C(c1ccccc1)=O)(C(CCC)N2)=C(C)NC2=S",
    "HIT":0.0,
    "question":"Can C(C(c1ccccc1)=O)(C(CCC)N2)=C(C)NC2=S act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":10260
  },
  {
    "COADD_ID":"CO-ADD:0311697",
    "INHIB_AVE":-11.3,
    "SMILES":"C(CSCC(=O)OCC(=O)c1ccc(cc1)Br)(=O)Nc(cc2)ccc2Br",
    "HIT":0.0,
    "question":"Does the proposed molecule C(CSCC(=O)OCC(=O)c1ccc(cc1)Br)(=O)Nc(cc2)ccc2Br exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":79596
  },
  {
    "COADD_ID":"CO-ADD:0235602",
    "INHIB_AVE":-0.81,
    "SMILES":"S(=O)(=O)(N(CC1)CCO1)c2c(Br)ccc(c2)C(=O)Nc3sc(c4c3C#N)CCCC4",
    "HIT":0.0,
    "question":"Can S(=O)(=O)(N(CC1)CCO1)c2c(Br)ccc(c2)C(=O)Nc3sc(c4c3C#N)CCCC4 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":60475
  },
  {
    "COADD_ID":"CO-ADD:0330873",
    "INHIB_AVE":-12.02,
    "SMILES":"n1(cnn2)c2SCC(c(ccc(c34)OCCO3)c4)=N1",
    "HIT":0.0,
    "question":"Is n1(cnn2)c2SCC(c(ccc(c34)OCCO3)c4)=N1 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":80034
  },
  {
    "COADD_ID":"CO-ADD:0220447",
    "INHIB_AVE":7.39,
    "SMILES":"c(Nc(ccc(c1C)C)c1)(nc(N\\N=C(\\C)\/c2ccc(cc2)NC(C)=O)nc3Nc(cc4)ccc4[N+](=O)[O-])n3",
    "HIT":0.0,
    "question":"Is c(Nc(ccc(c1C)C)c1)(nc(N\\N=C(\\C)\/c2ccc(cc2)NC(C)=O)nc3Nc(cc4)ccc4[N+](=O)[O-])n3 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":25505
  },
  {
    "COADD_ID":"CO-ADD:0135678",
    "INHIB_AVE":15.71,
    "SMILES":"C1C(O)C(O)C(O)CC1C(OC)=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C1C(O)C(O)C(O)CC1C(OC)=O?",
    "answer":"No",
    "_id":6703
  },
  {
    "COADD_ID":"CO-ADD:0292897",
    "INHIB_AVE":-8.71,
    "SMILES":"n1(n2)c(cc2C(=O)N(CC3)CCN3c4ccccc4OC)nc5c(CCc(cccc6)c56)c1C(F)(F)F",
    "HIT":0.0,
    "question":"Can n1(n2)c(cc2C(=O)N(CC3)CCN3c4ccccc4OC)nc5c(CCc(cccc6)c56)c1C(F)(F)F act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":77533
  },
  {
    "COADD_ID":"CO-ADD:0217930",
    "INHIB_AVE":9.79,
    "SMILES":"c12c(CC(C)(C)CC1=O)nc(c3c2N)ccc(C)c3.Cl",
    "HIT":0.0,
    "question":"Can c12c(CC(C)(C)CC1=O)nc(c3c2N)ccc(C)c3.Cl effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":17596
  },
  {
    "COADD_ID":"CO-ADD:0244548",
    "INHIB_AVE":7.94,
    "SMILES":"c(c(C)cc(c1C(c2ccccc2)=O)C)(c1)C(c3ccccc3)=O",
    "HIT":0.0,
    "question":"Does c(c(C)cc(c1C(c2ccccc2)=O)C)(c1)C(c3ccccc3)=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":23420
  },
  {
    "COADD_ID":"CO-ADD:0135772",
    "INHIB_AVE":4.04,
    "SMILES":"N1=CC(=CN([H])C2=S)N2C=C1",
    "HIT":0.0,
    "question":"Can exposure to N1=CC(=CN([H])C2=S)N2C=C1 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":39993
  },
  {
    "COADD_ID":"CO-ADD:0255336",
    "INHIB_AVE":7.7,
    "SMILES":"C1(c2cccc(F)c2)C(C(OCC)=O)C(=O)CC(C)(O)C1C(OCC)=O",
    "HIT":0.0,
    "question":"Does C1(c2cccc(F)c2)C(C(OCC)=O)C(=O)CC(C)(O)C1C(OCC)=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":24324
  },
  {
    "COADD_ID":"CO-ADD:0293474",
    "INHIB_AVE":-10.82,
    "SMILES":"[N+](=O)([O-])c(cc1)ccc1C(=O)Nc(ccc(c23)OCO2)c3",
    "HIT":0.0,
    "question":"Does [N+](=O)([O-])c(cc1)ccc1C(=O)Nc(ccc(c23)OCO2)c3 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":79287
  },
  {
    "COADD_ID":"CO-ADD:0294505",
    "INHIB_AVE":4.56,
    "SMILES":"C(C(c1ccccc1)=O)(C2c3ccc(c(OC)c3)O)=C(O)C(N2CCCC(O)=O)=O",
    "HIT":0.0,
    "question":"Can C(C(c1ccccc1)=O)(C2c3ccc(c(OC)c3)O)=C(O)C(N2CCCC(O)=O)=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":37628
  },
  {
    "COADD_ID":"CO-ADD:0160380",
    "INHIB_AVE":6.93,
    "SMILES":"[O-][N+](C(C=C1)=CC=C1C(OC(C(OC)=C2)=CC=C2\/C=N\/NC(COC3=CC=C(C=C3)C(C)(C)CC(C)(C)C)=O)=O)=O",
    "HIT":0.0,
    "question":"Can [O-][N+](C(C=C1)=CC=C1C(OC(C(OC)=C2)=CC=C2\/C=N\/NC(COC3=CC=C(C=C3)C(C)(C)CC(C)(C)C)=O)=O)=O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":27286
  },
  {
    "COADD_ID":"CO-ADD:0155923",
    "INHIB_AVE":-5.35,
    "SMILES":"O=C(N1C2=CC=CC=C2)C(C3(C(NC4=C3C=C(Br)C=C4Br)=O)C(C(N5C6=CC=CC=C6)=O)=C(C)N5C)=C(C)N1C",
    "HIT":0.0,
    "question":"Can O=C(N1C2=CC=CC=C2)C(C3(C(NC4=C3C=C(Br)C=C4Br)=O)C(C(N5C6=CC=CC=C6)=O)=C(C)N5C)=C(C)N1C effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":72557
  },
  {
    "COADD_ID":"CO-ADD:0258751",
    "INHIB_AVE":7.38,
    "SMILES":"c1(NC(=O)CC2c3ccccc3OCCC)c2ccc(cccc4)c14",
    "HIT":0.0,
    "question":"Is c1(NC(=O)CC2c3ccccc3OCCC)c2ccc(cccc4)c14 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":25551
  },
  {
    "COADD_ID":"CO-ADD:0227282",
    "INHIB_AVE":3.07,
    "SMILES":"C(CNc1cccc(cccc2)c12)(=O)N\\N=C\\c(cc3)ccc3C(O)=O",
    "HIT":0.0,
    "question":"Can exposure to C(CNc1cccc(cccc2)c12)(=O)N\\N=C\\c(cc3)ccc3C(O)=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":44327
  },
  {
    "COADD_ID":"CO-ADD:0257398",
    "INHIB_AVE":0.83,
    "SMILES":"N(Cc1ccccc1Cl)(c(c2)c(N3Cc4ccccc4Cl)cc([N+](=O)[O-])c2[N+](=O)[O-])C3=O",
    "HIT":0.0,
    "question":"Does treatment with N(Cc1ccccc1Cl)(c(c2)c(N3Cc4ccccc4Cl)cc([N+](=O)[O-])c2[N+](=O)[O-])C3=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":54170
  },
  {
    "COADD_ID":"CO-ADD:0293717",
    "INHIB_AVE":0.44,
    "SMILES":"n1c(c2ccc(cc2)Cl)csc1Nc(cc3)ccc3N",
    "HIT":0.0,
    "question":"Does the proposed molecule n1c(c2ccc(cc2)Cl)csc1Nc(cc3)ccc3N exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":55724
  },
  {
    "COADD_ID":"CO-ADD:0323959",
    "INHIB_AVE":-11.68,
    "SMILES":"S(=O)(=O)(N(CC1)CCN1C23CC4CC(CC(C4)C2)C3)c5ccc(c(cccc6)c56)OCC",
    "HIT":0.0,
    "question":"Can exposure to S(=O)(=O)(N(CC1)CCN1C23CC4CC(CC(C4)C2)C3)c5ccc(c(cccc6)c56)OCC lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":79824
  },
  {
    "COADD_ID":"CO-ADD:0154516",
    "INHIB_AVE":-2.16,
    "SMILES":"O=C(C1=CC=CC2=C1C=CC=C2)N\/N=CC3=CNC4=CC=CC=C43",
    "HIT":0.0,
    "question":"Can O=C(C1=CC=CC2=C1C=CC=C2)N\/N=CC3=CNC4=CC=CC=C43 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":64834
  },
  {
    "COADD_ID":"CO-ADD:0255908",
    "INHIB_AVE":5.82,
    "SMILES":"C1(C(OCCC)=O)=C(C)NC(NC1c(cc2OC)cc(c2OC)OC)=O",
    "HIT":0.0,
    "question":"Is C1(C(OCCC)=O)=C(C)NC(NC1c(cc2OC)cc(c2OC)OC)=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":32024
  },
  {
    "COADD_ID":"CO-ADD:0166712",
    "INHIB_AVE":51.42,
    "SMILES":"c12c(c(nn1c3ccccc3)C)C(C(C#N)=C(N)O2)c(cc4)ccc4C(C)C.[Na+]",
    "HIT":0.0,
    "question":"Does treatment with c12c(c(nn1c3ccccc3)C)C(C(C#N)=C(N)O2)c(cc4)ccc4C(C)C.[Na+] result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":479
  },
  {
    "COADD_ID":"CO-ADD:0220044",
    "INHIB_AVE":8.24,
    "SMILES":"[N+](=O)([O-])c(cc1)ccc1C(=O)C(C#N)C(OCC)=O",
    "HIT":0.0,
    "question":"Can exposure to [N+](=O)([O-])c(cc1)ccc1C(=O)C(C#N)C(OCC)=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":22316
  },
  {
    "COADD_ID":"CO-ADD:0284682",
    "INHIB_AVE":4.51,
    "SMILES":"C1(C2c(cc3)ccc3C(OC)=O)=C(CC(C)(C)CC1=O)NC(CC(C)(C)CC4=O)=C24",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C1(C2c(cc3)ccc3C(OC)=O)=C(CC(C)(C)CC1=O)NC(CC(C)(C)CC4=O)=C24?",
    "answer":"No",
    "_id":37880
  },
  {
    "COADD_ID":"CO-ADD:0162977",
    "INHIB_AVE":11.06,
    "SMILES":"C(=O)(NCC(=O)N\\N=C\\c(cc1)ccn1)c2ccc(c(OC)c2)OC",
    "HIT":0.0,
    "question":"Is C(=O)(NCC(=O)N\\N=C\\c(cc1)ccn1)c2ccc(c(OC)c2)OC effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":14394
  },
  {
    "COADD_ID":"CO-ADD:0257411",
    "INHIB_AVE":9.9,
    "SMILES":"c1(NC(=O)Cc2cccc(cccc3)c23)sc(c(C)c1C(OCC)=O)C",
    "HIT":0.0,
    "question":"Is c1(NC(=O)Cc2cccc(cccc3)c23)sc(c(C)c1C(OCC)=O)C effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":17273
  },
  {
    "COADD_ID":"CO-ADD:0255608",
    "INHIB_AVE":1.24,
    "SMILES":"N1(c2ccccc2)C(=O)c3c(c(ccc4Nc5ccccc5)C1=O)c4ccc3",
    "HIT":0.0,
    "question":"Is N1(c2ccccc2)C(=O)c3c(c(ccc4Nc5ccccc5)C1=O)c4ccc3 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":52408
  },
  {
    "COADD_ID":"CO-ADD:0324098",
    "INHIB_AVE":9.19,
    "SMILES":"n(c(N)cc(n1)O)c1SCC(OCC)=O",
    "HIT":0.0,
    "question":"Does treatment with n(c(N)cc(n1)O)c1SCC(OCC)=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":19328
  },
  {
    "COADD_ID":"CO-ADD:0259052",
    "INHIB_AVE":-3.03,
    "SMILES":"C(\/CC1C)(=C\/c2ccccc2)\\C(=O)\\C(\\C1)=C\\c3ccccc3",
    "HIT":0.0,
    "question":"Does C(\/CC1C)(=C\/c2ccccc2)\\C(=O)\\C(\\C1)=C\\c3ccccc3 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":67320
  },
  {
    "COADD_ID":"CO-ADD:0149049",
    "INHIB_AVE":11.22,
    "SMILES":"C(C)(C(O)CC1)(CC2)C1C(C23)CCc(cc(c(Br)c4)O)c34",
    "HIT":0.0,
    "question":"Is C(C)(C(O)CC1)(CC2)C1C(C23)CCc(cc(c(Br)c4)O)c34 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":14052
  },
  {
    "COADD_ID":"CO-ADD:0320954",
    "INHIB_AVE":-3.28,
    "SMILES":"c12c(cc(cc1NC(C)=O)[N+](=O)[O-])oc(c3ccccc3)c2",
    "HIT":0.0,
    "question":"Is c12c(cc(cc1NC(C)=O)[N+](=O)[O-])oc(c3ccccc3)c2 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":67940
  },
  {
    "COADD_ID":"CO-ADD:0256763",
    "INHIB_AVE":4.76,
    "SMILES":"c(C#N)(c(N([H])[H])n(n1)CCO[H])c1\\C(\\C#N)=C\\c(ccc(c2OC)OCC)c2",
    "HIT":0.0,
    "question":"Does c(C#N)(c(N([H])[H])n(n1)CCO[H])c1\\C(\\C#N)=C\\c(ccc(c2OC)OCC)c2 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":36721
  },
  {
    "COADD_ID":"CO-ADD:0312013",
    "INHIB_AVE":2.22,
    "SMILES":"N(CC(COc1ccccc1)OC2c3ccc(cc3Cl)Cl)(C(c4ccccc4)=O)O2",
    "HIT":0.0,
    "question":"Is N(CC(COc1ccccc1)OC2c3ccc(cc3Cl)Cl)(C(c4ccccc4)=O)O2 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":48128
  },
  {
    "COADD_ID":"CO-ADD:0215726",
    "INHIB_AVE":15.59,
    "SMILES":"c1(C#N)c(C)c(sc1\\N=C\\c(cc(Br)cc2Br)c2O)C",
    "HIT":0.0,
    "question":"Does c1(C#N)c(C)c(sc1\\N=C\\c(cc(Br)cc2Br)c2O)C demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":6832
  },
  {
    "COADD_ID":"CO-ADD:0218082",
    "INHIB_AVE":11.68,
    "SMILES":"c1(\\C(\\C)=N\\NC(=O)c2ccc(cc2)C)oc(cc1C)C",
    "HIT":0.0,
    "question":"Is c1(\\C(\\C)=N\\NC(=O)c2ccc(cc2)C)oc(cc1C)C effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":13080
  },
  {
    "COADD_ID":"CO-ADD:0319299",
    "INHIB_AVE":9.18,
    "SMILES":"c1(C=Nc(c2O3)ccc(cccc4)c24)c3cc(cc1[N+](=O)[O-])[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Is c1(C=Nc(c2O3)ccc(cccc4)c24)c3cc(cc1[N+](=O)[O-])[N+](=O)[O-] effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":19370
  },
  {
    "COADD_ID":"CO-ADD:0242656",
    "INHIB_AVE":22.82,
    "SMILES":"N1C(=O)\\C(\\SC1=S)=C\\c2ccccc2OC(C)=O",
    "HIT":0.0,
    "question":"Does the proposed molecule N1C(=O)\\C(\\SC1=S)=C\\c2ccccc2OC(C)=O exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":1680
  },
  {
    "COADD_ID":"CO-ADD:0321316",
    "INHIB_AVE":8.47,
    "SMILES":"N1(N=C(S2)CCC)C2=NC(=O)\\C(=C\/c(ccc(c3OCC)OCCOc4ccccc4C)c3)\\C1=N",
    "HIT":0.0,
    "question":"Does the proposed molecule N1(N=C(S2)CCC)C2=NC(=O)\\C(=C\/c(ccc(c3OCC)OCCOc4ccccc4C)c3)\\C1=N exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":21558
  },
  {
    "COADD_ID":"CO-ADD:0258548",
    "INHIB_AVE":4.52,
    "SMILES":"C(=C\/c(ccc(c1OC)OCC(O)=O)c1)(\/C2=O)\\C(=O)c3c2cccc3",
    "HIT":0.0,
    "question":"Does C(=C\/c(ccc(c1OC)OCC(O)=O)c1)(\/C2=O)\\C(=O)c3c2cccc3 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":37821
  },
  {
    "COADD_ID":"CO-ADD:0155045",
    "INHIB_AVE":-3.51,
    "SMILES":"[O-][N+](C1=CC(OC2=CC=C(C=C2)C(NC3=NC4=C(C=CC=C4)N3CCN(CC)CC)=O)=CC(OC5=CC=CC(Cl)=C5)=C1)=O",
    "HIT":0.0,
    "question":"Does [O-][N+](C1=CC(OC2=CC=C(C=C2)C(NC3=NC4=C(C=CC=C4)N3CCN(CC)CC)=O)=CC(OC5=CC=CC(Cl)=C5)=C1)=O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":68542
  },
  {
    "COADD_ID":"CO-ADD:0304192",
    "INHIB_AVE":12.75,
    "SMILES":"C(=O)(C(=O)NCc(cc1)ccc1OC)Nc2cccc(C)c2C",
    "HIT":0.0,
    "question":"Is C(=O)(C(=O)NCc(cc1)ccc1OC)Nc2cccc(C)c2C effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":11028
  },
  {
    "COADD_ID":"CO-ADD:0160441",
    "INHIB_AVE":7.0,
    "SMILES":"[O-][N+](C(C=C1)=CC=C1\/C=N\/C2=CC(N=C(C3=CC=C(I)C=C3)O4)=C4C=C2)=O",
    "HIT":0.0,
    "question":"Does treatment with [O-][N+](C(C=C1)=CC=C1\/C=N\/C2=CC(N=C(C3=CC=C(I)C=C3)O4)=C4C=C2)=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":26987
  },
  {
    "COADD_ID":"CO-ADD:0245658",
    "INHIB_AVE":4.88,
    "SMILES":"N1(c2ccc(cc2)CC)C(c3ccc(cc3)C)Nc(c4C1=O)cccc4",
    "HIT":0.0,
    "question":"Does treatment with N1(c2ccc(cc2)CC)C(c3ccc(cc3)C)Nc(c4C1=O)cccc4 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":36165
  },
  {
    "COADD_ID":"CO-ADD:0320480",
    "INHIB_AVE":4.09,
    "SMILES":"n1(c(cccc2C(F)(F)F)c2)c3c(cn1)ccc(c3)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Can n1(c(cccc2C(F)(F)F)c2)c3c(cn1)ccc(c3)[N+](=O)[O-] effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":39762
  },
  {
    "COADD_ID":"CO-ADD:0304268",
    "INHIB_AVE":6.75,
    "SMILES":"C1(=O)Nc(c2N1)ccc(c2)NCc3cccc(OC)c3OCc4ccccc4Cl",
    "HIT":0.0,
    "question":"Is C1(=O)Nc(c2N1)ccc(c2)NCc3cccc(OC)c3OCc4ccccc4Cl capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":28032
  },
  {
    "COADD_ID":"CO-ADD:0283983",
    "INHIB_AVE":-9.75,
    "SMILES":"C(C(=O)OC(C)C)(=C(C)NC(=C12)CC(CC1=O)c3ccccc3)C2c4ccccc4OCc5ccccc5",
    "HIT":0.0,
    "question":"Can C(C(=O)OC(C)C)(=C(C)NC(=C12)CC(CC1=O)c3ccccc3)C2c4ccccc4OCc5ccccc5 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":78510
  },
  {
    "COADD_ID":"CO-ADD:0327686",
    "INHIB_AVE":-1.15,
    "SMILES":"N1(CC)\\C(=N\/CC)\\S\\C(=C\\c2sccc2C)\\C1=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound N1(CC)\\C(=N\/CC)\\S\\C(=C\\c2sccc2C)\\C1=O?",
    "answer":"No",
    "_id":61604
  },
  {
    "COADD_ID":"CO-ADD:0277988",
    "INHIB_AVE":7.75,
    "SMILES":"c1(NC(CCC)=O)nnc(COc(cc2)ccc2C(C)(C)C)s1",
    "HIT":0.0,
    "question":"Is c1(NC(CCC)=O)nnc(COc(cc2)ccc2C(C)(C)C)s1 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":24157
  },
  {
    "COADD_ID":"CO-ADD:0237297",
    "INHIB_AVE":5.17,
    "SMILES":"CC(N1CCN(CC1)S(=O)(=O)c2ccc(cc2)C(C)(C)C)C(=O)N3CCCC3",
    "HIT":0.0,
    "question":"Does the proposed molecule CC(N1CCN(CC1)S(=O)(=O)c2ccc(cc2)C(C)(C)C)C(=O)N3CCCC3 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":34859
  },
  {
    "COADD_ID":"CO-ADD:0305897",
    "INHIB_AVE":8.48,
    "SMILES":"N1(CCc(cccc2)c12)C(=O)COc3ccccc3C",
    "HIT":0.0,
    "question":"Does N1(CCc(cccc2)c12)C(=O)COc3ccccc3C demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":21529
  },
  {
    "COADD_ID":"CO-ADD:0279042",
    "INHIB_AVE":7.62,
    "SMILES":"n1c(N)c(C#N)cc(C#N)c1SCC(=O)Nc2ccc(cc2Cl)NC(CSc3c(C#N)cc(c(N)n3)C#N)=O.Cl.Cl",
    "HIT":0.0,
    "question":"Can exposure to n1c(N)c(C#N)cc(C#N)c1SCC(=O)Nc2ccc(cc2Cl)NC(CSc3c(C#N)cc(c(N)n3)C#N)=O.Cl.Cl lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":24615
  },
  {
    "COADD_ID":"CO-ADD:0284694",
    "INHIB_AVE":9.91,
    "SMILES":"c1(SCc2ccc(c3c2cccc3)F)sc4c(ccc(c4)\\N=C\\c5ccccc5O)n1",
    "HIT":0.0,
    "question":"Can c1(SCc2ccc(c3c2cccc3)F)sc4c(ccc(c4)\\N=C\\c5ccccc5O)n1 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":17227
  },
  {
    "COADD_ID":"CO-ADD:0303686",
    "INHIB_AVE":12.16,
    "SMILES":"S(=O)(=O)(c1ccc(cc1)C)N(CC2)CCN2c3scc(c4ccccc4)n3",
    "HIT":0.0,
    "question":"Can S(=O)(=O)(c1ccc(cc1)C)N(CC2)CCN2c3scc(c4ccccc4)n3 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":12149
  },
  {
    "COADD_ID":"CO-ADD:0299339",
    "INHIB_AVE":-2.79,
    "SMILES":"n12c(S\\C(=C\/c3ccccc3)\\C1=O)nc(cc(Br)cn4)c24",
    "HIT":0.0,
    "question":"Does n12c(S\\C(=C\/c3ccccc3)\\C1=O)nc(cc(Br)cn4)c24 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":66644
  },
  {
    "COADD_ID":"CO-ADD:0166506",
    "INHIB_AVE":7.47,
    "SMILES":"c(OC)(c(OC)c1)c(OC)cc1C(=O)NCc2ccccc2F",
    "HIT":0.0,
    "question":"Can c(OC)(c(OC)c1)c(OC)cc1C(=O)NCc2ccccc2F effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":25177
  },
  {
    "COADD_ID":"CO-ADD:0223159",
    "INHIB_AVE":3.52,
    "SMILES":"[N+](=O)([O-])c(c1)cc(c(O)c1\\C=N\\NC(=O)c(ccc(n2)CO)c2)Br",
    "HIT":0.0,
    "question":"Does treatment with [N+](=O)([O-])c(c1)cc(c(O)c1\\C=N\\NC(=O)c(ccc(n2)CO)c2)Br result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":42309
  },
  {
    "COADD_ID":"CO-ADD:0218256",
    "INHIB_AVE":-0.68,
    "SMILES":"C1(=C(O)CC(C)(C)CC1=O)C(c2ccc(c(OC)c2)OC)C3C(=O)CC(CC3=O)(C)C",
    "HIT":0.0,
    "question":"Can C1(=C(O)CC(C)(C)CC1=O)C(c2ccc(c(OC)c2)OC)C3C(=O)CC(CC3=O)(C)C act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":60030
  },
  {
    "COADD_ID":"CO-ADD:0248247",
    "INHIB_AVE":4.78,
    "SMILES":"s1c(c(cccn2)c2)nnc1NC(=O)c3ccccc3Br",
    "HIT":0.0,
    "question":"Can exposure to s1c(c(cccn2)c2)nnc1NC(=O)c3ccccc3Br lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":36636
  },
  {
    "COADD_ID":"CO-ADD:0287630",
    "INHIB_AVE":-4.45,
    "SMILES":"c(C(=O)c1ccc(cc1)Cl)(sc(c23)nc(c(C(=O)Nc4ccccc4)c2c5ccccc5Cl)C)c3N",
    "HIT":0.0,
    "question":"Is c(C(=O)c1ccc(cc1)Cl)(sc(c23)nc(c(C(=O)Nc4ccccc4)c2c5ccccc5Cl)C)c3N capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":70738
  },
  {
    "COADD_ID":"CO-ADD:0166174",
    "INHIB_AVE":10.43,
    "SMILES":"[N+](=O)([O-])c1cc(ccc1OC(=O)c2ccco2)\\C=N\\NC(c(cc3)ccn3)=O",
    "HIT":0.0,
    "question":"Does [N+](=O)([O-])c1cc(ccc1OC(=O)c2ccco2)\\C=N\\NC(c(cc3)ccn3)=O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":15899
  },
  {
    "COADD_ID":"CO-ADD:0258364",
    "INHIB_AVE":19.85,
    "SMILES":"C1(C2CCCC1C2c3ccccc3)C(=O)Oc4ccccc4",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C1(C2CCCC1C2c3ccccc3)C(=O)Oc4ccccc4?",
    "answer":"No",
    "_id":2962
  },
  {
    "COADD_ID":"CO-ADD:0283240",
    "INHIB_AVE":-8.48,
    "SMILES":"C(C(OCC)=O)(C1c(cc2OC)cc(c2OC)OC)=C(N)N(C(CC(C)(C)CC3=O)=C13)c4cccc(C)c4",
    "HIT":0.0,
    "question":"Can C(C(OCC)=O)(C1c(cc2OC)cc(c2OC)OC)=C(N)N(C(CC(C)(C)CC3=O)=C13)c4cccc(C)c4 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":77276
  },
  {
    "COADD_ID":"CO-ADD:0250594",
    "INHIB_AVE":7.61,
    "SMILES":"N1(c2ccc(c(Cl)c2)F)C(c3ccc(cc3)OC)Nc(c4C1=O)cccc4",
    "HIT":0.0,
    "question":"Is N1(c2ccc(c(Cl)c2)F)C(c3ccc(cc3)OC)Nc(c4C1=O)cccc4 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":24636
  },
  {
    "COADD_ID":"CO-ADD:0242974",
    "INHIB_AVE":6.05,
    "SMILES":"C(=O)(C=C)NC(C)(C)CCN1CCCCC1",
    "HIT":0.0,
    "question":"Can exposure to C(=O)(C=C)NC(C)(C)CCN1CCCCC1 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":31047
  },
  {
    "COADD_ID":"CO-ADD:0237240",
    "INHIB_AVE":8.29,
    "SMILES":"Cc1cc(C)c2cc([nH]c2c1)C(=O)NC3CCCCCCC3",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound Cc1cc(C)c2cc([nH]c2c1)C(=O)NC3CCCCCCC3?",
    "answer":"No",
    "_id":22143
  },
  {
    "COADD_ID":"CO-ADD:0137625",
    "INHIB_AVE":-2.45,
    "SMILES":"c1(C(=O)NN=Cc(c(Cl)ccc2[N+](=O)[O-])c2)nonc1N",
    "HIT":0.0,
    "question":"Can c1(C(=O)NN=Cc(c(Cl)ccc2[N+](=O)[O-])c2)nonc1N effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":65699
  },
  {
    "COADD_ID":"CO-ADD:0162389",
    "INHIB_AVE":3.61,
    "SMILES":"c1(c2ccc(cc2)\\N=C\/c3ccccc3O)[nH]c(c(ccc4c(ccc(c5[nH]6)nc6c7ccc(cc7)\\N=C\/c8ccccc8O)c5)n1)c4",
    "HIT":0.0,
    "question":"Does c1(c2ccc(cc2)\\N=C\/c3ccccc3O)[nH]c(c(ccc4c(ccc(c5[nH]6)nc6c7ccc(cc7)\\N=C\/c8ccccc8O)c5)n1)c4 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":41923
  },
  {
    "COADD_ID":"CO-ADD:0301246",
    "INHIB_AVE":33.73,
    "SMILES":"C(=CNC=C1C(OC)=O)(C(OC)=O)C1c2ccc(cc2)OCC",
    "HIT":0.0,
    "question":"Does C(=CNC=C1C(OC)=O)(C(OC)=O)C1c2ccc(cc2)OCC show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":650
  },
  {
    "COADD_ID":"CO-ADD:0287153",
    "INHIB_AVE":-2.82,
    "SMILES":"C(C(=O)NCc1ccccc1)(=C2)C(=O)NC(C)=C2\\C(\\C)=N\/Cc3ccccc3",
    "HIT":0.0,
    "question":"Does C(C(=O)NCc1ccccc1)(=C2)C(=O)NC(C)=C2\\C(\\C)=N\/Cc3ccccc3 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":66728
  },
  {
    "COADD_ID":"CO-ADD:0156884",
    "INHIB_AVE":2.82,
    "SMILES":"O=C(OC)NC(N=C1)=CC=C1Cl",
    "HIT":0.0,
    "question":"Does treatment with O=C(OC)NC(N=C1)=CC=C1Cl result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":45456
  },
  {
    "COADD_ID":"CO-ADD:0228541",
    "INHIB_AVE":4.83,
    "SMILES":"N1C(SCC(=O)c2ccc(cc2)Br)=NN=C(C)C1=O",
    "HIT":0.0,
    "question":"Does N1C(SCC(=O)c2ccc(cc2)Br)=NN=C(C)C1=O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":36391
  },
  {
    "COADD_ID":"CO-ADD:0231316",
    "INHIB_AVE":100.62,
    "SMILES":"C(=O)(Oc(cc1)ccc1\\C=N\\c(cc2)ccc2Br)\\C=C\\C(=O)Oc(cc3)ccc3\\C=N\\c(cc4)ccc4Br",
    "HIT":0.0,
    "question":"Does the proposed molecule C(=O)(Oc(cc1)ccc1\\C=N\\c(cc2)ccc2Br)\\C=C\\C(=O)Oc(cc3)ccc3\\C=N\\c(cc4)ccc4Br exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":263
  },
  {
    "COADD_ID":"CO-ADD:0229002",
    "INHIB_AVE":5.14,
    "SMILES":"S(c1ccccc1)(=O)(=O)Oc(cc2)ccc2OCc3ccccc3",
    "HIT":0.0,
    "question":"Can S(c1ccccc1)(=O)(=O)Oc(cc2)ccc2OCc3ccccc3 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":35022
  },
  {
    "COADD_ID":"CO-ADD:0227400",
    "INHIB_AVE":10.12,
    "SMILES":"C(CNc1ccc(cc1Br)Br)(=O)N\\N=C\\c(cc2)ccc2Cl",
    "HIT":0.0,
    "question":"Can C(CNc1ccc(cc1Br)Br)(=O)N\\N=C\\c(cc2)ccc2Cl effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":16692
  },
  {
    "COADD_ID":"CO-ADD:0215641",
    "INHIB_AVE":8.11,
    "SMILES":"c1(ccccc1O)C(=O)N\\N=C(\/C)\\CC(=O)Nc2cc(C)ccc2OC",
    "HIT":0.0,
    "question":"Does c1(ccccc1O)C(=O)N\\N=C(\/C)\\CC(=O)Nc2cc(C)ccc2OC show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":22819
  },
  {
    "COADD_ID":"CO-ADD:0291101",
    "INHIB_AVE":-10.7,
    "SMILES":"N1(C2c3ccc(c4c3)OCO4)C(S\\C(=C\/c(cc5)ccc5O)\\C1=O)=NC(c6ccccc6)=C2C(OCC)=O",
    "HIT":0.0,
    "question":"Does N1(C2c3ccc(c4c3)OCO4)C(S\\C(=C\/c(cc5)ccc5O)\\C1=O)=NC(c6ccccc6)=C2C(OCC)=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":79206
  },
  {
    "COADD_ID":"CO-ADD:0228051",
    "INHIB_AVE":-8.09,
    "SMILES":"c1(oc(c2n1)ccc(C)c2)c3ccc(cc3O)\\N=C\\c(cc(C)c(c4Br)C)c4O",
    "HIT":0.0,
    "question":"Is c1(oc(c2n1)ccc(C)c2)c3ccc(cc3O)\\N=C\\c(cc(C)c(c4Br)C)c4O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":76836
  },
  {
    "COADD_ID":"CO-ADD:0257596",
    "INHIB_AVE":-5.95,
    "SMILES":"C(=N\\c1ccccn1)(\/N(c2ccccc2)C(=C3Oc(cc4)ccc4Cl)c5ccccc5)\\S3",
    "HIT":0.0,
    "question":"Does treatment with C(=N\\c1ccccn1)(\/N(c2ccccc2)C(=C3Oc(cc4)ccc4Cl)c5ccccc5)\\S3 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":73654
  },
  {
    "COADD_ID":"CO-ADD:0245620",
    "INHIB_AVE":0.18,
    "SMILES":"C1(=S)N(c(cc2)ccc2C(O)=O)C3(\\C(=N\\c4cccc(C)c4)\\N1)CCCCC3",
    "HIT":0.0,
    "question":"Does the proposed molecule C1(=S)N(c(cc2)ccc2C(O)=O)C3(\\C(=N\\c4cccc(C)c4)\\N1)CCCCC3 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":56773
  },
  {
    "COADD_ID":"CO-ADD:0245850",
    "INHIB_AVE":24.23,
    "SMILES":"C1(N(C(CCl)=O)c2ccccc2Cl)=NC(CS1)=O",
    "HIT":0.0,
    "question":"Is C1(N(C(CCl)=O)c2ccccc2Cl)=NC(CS1)=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":1303
  },
  {
    "COADD_ID":"CO-ADD:0331718",
    "INHIB_AVE":9.03,
    "SMILES":"C1(NC(CCc2ccccc2)=O)(C(F)(F)F)C(=O)N(C(=O)N1)C",
    "HIT":0.0,
    "question":"Can exposure to C1(NC(CCc2ccccc2)=O)(C(F)(F)F)C(=O)N(C(=O)N1)C lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":19800
  },
  {
    "COADD_ID":"CO-ADD:0255776",
    "INHIB_AVE":5.81,
    "SMILES":"C1(C(=O)OCC(Cl)(Cl)Cl)=C(C)NC(NC1c2ccccc2OCCCC)=O",
    "HIT":0.0,
    "question":"Does the proposed molecule C1(C(=O)OCC(Cl)(Cl)Cl)=C(C)NC(NC1c2ccccc2OCCCC)=O exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":32066
  },
  {
    "COADD_ID":"CO-ADD:0229711",
    "INHIB_AVE":22.46,
    "SMILES":"c1(NCC(=O)N\\N=C\\c2ccccc2Cl)c(Br)cc(cc1Br)Cl",
    "HIT":0.0,
    "question":"Is c1(NCC(=O)N\\N=C\\c2ccccc2Cl)c(Br)cc(cc1Br)Cl capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":1780
  },
  {
    "COADD_ID":"CO-ADD:0158092",
    "INHIB_AVE":6.2,
    "SMILES":"S=C(OC1=CC=C(C=C1)C(NC2=CC=CC=C2)=O)N(CC(C)C)CC(C)C",
    "HIT":0.0,
    "question":"Can exposure to S=C(OC1=CC=C(C=C1)C(NC2=CC=CC=C2)=O)N(CC(C)C)CC(C)C lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":30421
  },
  {
    "COADD_ID":"CO-ADD:0258831",
    "INHIB_AVE":-8.62,
    "SMILES":"C1(\\N=C\\c(cc2OC)cc(c2OC(C)=O)OC)=C(C)N(N(c3ccccc3)C1=O)C",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C1(\\N=C\\c(cc2OC)cc(c2OC(C)=O)OC)=C(C)N(N(c3ccccc3)C1=O)C?",
    "answer":"No",
    "_id":77440
  },
  {
    "COADD_ID":"CO-ADD:0283285",
    "INHIB_AVE":-6.04,
    "SMILES":"C12(c3c(cccc3)C(=NN1c4ccccc4)c5ccc(cc5)CC)SC(=NN2c6ccccc6)c7ccccc7",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C12(c3c(cccc3)C(=NN1c4ccccc4)c5ccc(cc5)CC)SC(=NN2c6ccccc6)c7ccccc7?",
    "answer":"No",
    "_id":73819
  },
  {
    "COADD_ID":"CO-ADD:0329533",
    "INHIB_AVE":2.11,
    "SMILES":"C1(=S)N(NC(=O)c2cccc(F)c2)C(C(=O)N1c3ccc(cc3)Cl)CC(=O)Nc(cc4)ccc4Cl",
    "HIT":0.0,
    "question":"Is C1(=S)N(NC(=O)c2cccc(F)c2)C(C(=O)N1c3ccc(cc3)Cl)CC(=O)Nc(cc4)ccc4Cl effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":48556
  },
  {
    "COADD_ID":"CO-ADD:0302380",
    "INHIB_AVE":2.18,
    "SMILES":"C(=C(C)NC(=C1C#N)SCC(=O)Nc2cc(Cl)cc(Cl)c2)(C(=O)Nc3ccccc3C)C1c4cccs4",
    "HIT":0.0,
    "question":"Can C(=C(C)NC(=C1C#N)SCC(=O)Nc2cc(Cl)cc(Cl)c2)(C(=O)Nc3ccccc3C)C1c4cccs4 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":48300
  },
  {
    "COADD_ID":"CO-ADD:0235934",
    "INHIB_AVE":-5.76,
    "SMILES":"C(C#N)(C1c2cccs2)=C(N)N(C(CCCC3=O)=C13)c(cc4)ccc4[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Does treatment with C(C#N)(C1c2cccs2)=C(N)N(C(CCCC3=O)=C13)c(cc4)ccc4[N+](=O)[O-] result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":73262
  },
  {
    "COADD_ID":"CO-ADD:0302174",
    "INHIB_AVE":-6.82,
    "SMILES":"C(=O)(Oc(cc1)ccc1C=O)c2cccs2",
    "HIT":0.0,
    "question":"Does the proposed molecule C(=O)(Oc(cc1)ccc1C=O)c2cccs2 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":75062
  },
  {
    "COADD_ID":"CO-ADD:0154459",
    "INHIB_AVE":11.01,
    "SMILES":"CNC(C1=CC2=CC(OC)=CC=C2N1)=O",
    "HIT":0.0,
    "question":"Is CNC(C1=CC2=CC(OC)=CC=C2N1)=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":14524
  },
  {
    "COADD_ID":"CO-ADD:0244487",
    "INHIB_AVE":10.74,
    "SMILES":"c(C(=O)c1ccc(cc1)Br)(c(N)c(c23)ccc(c4ccc(cc4)Br)n2)s3",
    "HIT":0.0,
    "question":"Does c(C(=O)c1ccc(cc1)Br)(c(N)c(c23)ccc(c4ccc(cc4)Br)n2)s3 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":15133
  },
  {
    "COADD_ID":"CO-ADD:0299439",
    "INHIB_AVE":4.59,
    "SMILES":"c1(C#N)c(SCC(=O)Nc2scc(c3ccccc3)n2)nc(cc1C(F)(F)F)c4ccccc4",
    "HIT":0.0,
    "question":"Does the proposed molecule c1(C#N)c(SCC(=O)Nc2scc(c3ccccc3)n2)nc(cc1C(F)(F)F)c4ccccc4 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":37507
  },
  {
    "COADD_ID":"CO-ADD:0232334",
    "INHIB_AVE":14.88,
    "SMILES":"c1(SCCC)[nH]c(c2n1)cccc2",
    "HIT":0.0,
    "question":"Can c1(SCCC)[nH]c(c2n1)cccc2 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":7747
  },
  {
    "COADD_ID":"CO-ADD:0278526",
    "INHIB_AVE":-10.32,
    "SMILES":"[nH]1c(C)c(c(C)c1C=O)C",
    "HIT":0.0,
    "question":"Is [nH]1c(C)c(c(C)c1C=O)C capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":78929
  },
  {
    "COADD_ID":"CO-ADD:0284868",
    "INHIB_AVE":5.74,
    "SMILES":"c1(c2c(sc1NC(=O)c3ccc(cc3)C)CCCCC2)C(=O)N(CC4)CCN4C",
    "HIT":0.0,
    "question":"Does the proposed molecule c1(c2c(sc1NC(=O)c3ccc(cc3)C)CCCCC2)C(=O)N(CC4)CCN4C exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":32373
  },
  {
    "COADD_ID":"CO-ADD:0155060",
    "INHIB_AVE":16.13,
    "SMILES":"ClC1=NSS\/C1=N\\C(N=C2)=CC=C2C",
    "HIT":0.0,
    "question":"Does ClC1=NSS\/C1=N\\C(N=C2)=CC=C2C demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":6210
  },
  {
    "COADD_ID":"CO-ADD:0295418",
    "INHIB_AVE":12.94,
    "SMILES":"C1(C(F)(F)F)(C(F)(F)F)NC(=O)N(C2=N1)CCS2",
    "HIT":0.0,
    "question":"Does C1(C(F)(F)F)(C(F)(F)F)NC(=O)N(C2=N1)CCS2 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":10685
  },
  {
    "COADD_ID":"CO-ADD:0217035",
    "INHIB_AVE":9.63,
    "SMILES":"C(C(c1ccccc1)=O)C(c(cc2)ccc2C(OC)=O)Nc(cc3)ccc3CCCC",
    "HIT":0.0,
    "question":"Can C(C(c1ccccc1)=O)C(c(cc2)ccc2C(OC)=O)Nc(cc3)ccc3CCCC act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":18051
  },
  {
    "COADD_ID":"CO-ADD:0304010",
    "INHIB_AVE":3.16,
    "SMILES":"C(C(OC)=O)(C1c(cc2)ccc2C(F)(F)F)=C(C)NC(CCCC3=O)=C13",
    "HIT":0.0,
    "question":"Can C(C(OC)=O)(C1c(cc2)ccc2C(F)(F)F)=C(C)NC(CCCC3=O)=C13 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":43901
  },
  {
    "COADD_ID":"CO-ADD:0231456",
    "INHIB_AVE":15.39,
    "SMILES":"N(\/c(cc1)ccc1c2ccc(cc2)\\N=C\\c(ccc(c3Cl)Cl)c3)=C\\c(ccc(c4Cl)Cl)c4",
    "HIT":0.0,
    "question":"Can exposure to N(\/c(cc1)ccc1c2ccc(cc2)\\N=C\\c(ccc(c3Cl)Cl)c3)=C\\c(ccc(c4Cl)Cl)c4 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":7096
  },
  {
    "COADD_ID":"CO-ADD:0218127",
    "INHIB_AVE":4.97,
    "SMILES":"N1(C(C)=O)[C@@H](c2ccc(cc2)Br)SC[C@H]1C(=O)Nc(cc3)ccc3OC",
    "HIT":0.0,
    "question":"Does N1(C(C)=O)[C@@H](c2ccc(cc2)Br)SC[C@H]1C(=O)Nc(cc3)ccc3OC demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":35762
  },
  {
    "COADD_ID":"CO-ADD:0229338",
    "INHIB_AVE":3.84,
    "SMILES":"c1(c2c(s3)CCCC2)c3N=C(C)N(\\N=C\\c(cc(cc4[N+](=O)[O-])[N+](=O)[O-])c4O)C1=O",
    "HIT":0.0,
    "question":"Can c1(c2c(s3)CCCC2)c3N=C(C)N(\\N=C\\c(cc(cc4[N+](=O)[O-])[N+](=O)[O-])c4O)C1=O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":40889
  },
  {
    "COADD_ID":"CO-ADD:0230029",
    "INHIB_AVE":2.77,
    "SMILES":"C([N+](=O)[O-])(C1c(cccc2[N+](=O)[O-])c2)=C(c3ccccc3C(OC)=O)OC(N)=C1C#N",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C([N+](=O)[O-])(C1c(cccc2[N+](=O)[O-])c2)=C(c3ccccc3C(OC)=O)OC(N)=C1C#N?",
    "answer":"No",
    "_id":45698
  },
  {
    "COADD_ID":"CO-ADD:0162477",
    "INHIB_AVE":0.21,
    "SMILES":"N1(CN2CCCCC2)C(=S)OC(c3ccccc3Cl)=N1",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound N1(CN2CCCCC2)C(=S)OC(c3ccccc3Cl)=N1?",
    "answer":"No",
    "_id":56645
  },
  {
    "COADD_ID":"CO-ADD:0218208",
    "INHIB_AVE":4.97,
    "SMILES":"S(=O)(=O)(c1cccc(c1)[N+](=O)[O-])N2CCCCC2",
    "HIT":0.0,
    "question":"Is S(=O)(=O)(c1cccc(c1)[N+](=O)[O-])N2CCCCC2 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":35765
  },
  {
    "COADD_ID":"CO-ADD:0226714",
    "INHIB_AVE":0.34,
    "SMILES":"N1(c(ccs2)c2C(N3Cc4cccs4)=O)C3=NN(Cc5cccc(Cl)c5)C1=O",
    "HIT":0.0,
    "question":"Is N1(c(ccs2)c2C(N3Cc4cccs4)=O)C3=NN(Cc5cccc(Cl)c5)C1=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":56112
  },
  {
    "COADD_ID":"CO-ADD:0137003",
    "INHIB_AVE":6.51,
    "SMILES":"O=C1C(=CN2CCCC2)CC(C(CC=C(CC(O)CC3)C34C)C4CC5)C15C",
    "HIT":0.0,
    "question":"Is O=C1C(=CN2CCCC2)CC(C(CC=C(CC(O)CC3)C34C)C4CC5)C15C capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":29079
  },
  {
    "COADD_ID":"CO-ADD:0162745",
    "INHIB_AVE":-7.65,
    "SMILES":"C1(C#N)=C(N)OC(=C2C1c(ccc3c4ccccc4Cl)o3)CCCC2=O",
    "HIT":0.0,
    "question":"Can C1(C#N)=C(N)OC(=C2C1c(ccc3c4ccccc4Cl)o3)CCCC2=O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":76269
  },
  {
    "COADD_ID":"CO-ADD:0318874",
    "INHIB_AVE":9.23,
    "SMILES":"n1(N)c(CSc2nnc(N)s2)nnc1CSc3nnc(N)s3",
    "HIT":0.0,
    "question":"Does n1(N)c(CSc2nnc(N)s2)nnc1CSc3nnc(N)s3 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":19246
  },
  {
    "COADD_ID":"CO-ADD:0231411",
    "INHIB_AVE":5.15,
    "SMILES":"[N+](=O)([O-])c1c(Cl)ccc(c1)c2ccc(\\C=N\\c3ccccc3F)o2",
    "HIT":0.0,
    "question":"Does the proposed molecule [N+](=O)([O-])c1c(Cl)ccc(c1)c2ccc(\\C=N\\c3ccccc3F)o2 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":34972
  },
  {
    "COADD_ID":"CO-ADD:0158074",
    "INHIB_AVE":10.97,
    "SMILES":"O=C(CCC1=CC=CC=C1)N\/N=C\/C2=CC=C(C=C2)F",
    "HIT":0.0,
    "question":"Can exposure to O=C(CCC1=CC=CC=C1)N\/N=C\/C2=CC=C(C=C2)F lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":14596
  },
  {
    "COADD_ID":"CO-ADD:0137186",
    "INHIB_AVE":19.89,
    "SMILES":"N12C(CC3C(CC(OC(=O)CCc(cc(OC)c4OC)cc4OC)C(OC)C3C(=O)OC)C1)c(c(CC2)c(ccc5OC)c6c5)n6[H]",
    "HIT":0.0,
    "question":"Is N12C(CC3C(CC(OC(=O)CCc(cc(OC)c4OC)cc4OC)C(OC)C3C(=O)OC)C1)c(c(CC2)c(ccc5OC)c6c5)n6[H] capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":2942
  },
  {
    "COADD_ID":"CO-ADD:0283028",
    "INHIB_AVE":16.76,
    "SMILES":"N1(Cc2ccco2)\\C(=N\\c(cc3)ccc3F)\\SC=C1c4ccc(cc4)CC.Br",
    "HIT":0.0,
    "question":"Is N1(Cc2ccco2)\\C(=N\\c(cc3)ccc3F)\\SC=C1c4ccc(cc4)CC.Br effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":5518
  },
  {
    "COADD_ID":"CO-ADD:0159678",
    "INHIB_AVE":-2.62,
    "SMILES":"OC1C[C@@H](O)[C@H](O)[C@@H]([C@H](O)CO)O1",
    "HIT":0.0,
    "question":"Is OC1C[C@@H](O)[C@H](O)[C@@H]([C@H](O)CO)O1 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":66174
  },
  {
    "COADD_ID":"CO-ADD:0258344",
    "INHIB_AVE":16.9,
    "SMILES":"N1(c2c(S3)cccc2)C3=NC=C(C(OCC)=O)C1=O",
    "HIT":0.0,
    "question":"Can exposure to N1(c2c(S3)cccc2)C3=NC=C(C(OCC)=O)C1=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":5374
  },
  {
    "COADD_ID":"CO-ADD:0228331",
    "INHIB_AVE":-16.61,
    "SMILES":"c1(C#N)c(N)nc(c2c1c(cccc3[N+](=O)[O-])c3)CCCCCC2",
    "HIT":0.0,
    "question":"Does c1(C#N)c(N)nc(c2c1c(cccc3[N+](=O)[O-])c3)CCCCCC2 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":81666
  },
  {
    "COADD_ID":"CO-ADD:0137114",
    "INHIB_AVE":-12.31,
    "SMILES":"Clc1cc(ccc1OCc2cccc(C(N(C)C)=O)c2)N(C(N)=N3)C(C)(C)N=C3N.C(S(O)(=O)=O)C",
    "HIT":0.0,
    "question":"Does Clc1cc(ccc1OCc2cccc(C(N(C)C)=O)c2)N(C(N)=N3)C(C)(C)N=C3N.C(S(O)(=O)=O)C show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":80212
  },
  {
    "COADD_ID":"CO-ADD:0222905",
    "INHIB_AVE":2.71,
    "SMILES":"N(=C\\c1cccc(Br)c1)\/c2ccnc(cccc3)c23",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound N(=C\\c1cccc(Br)c1)\/c2ccnc(cccc3)c23?",
    "answer":"No",
    "_id":45924
  },
  {
    "COADD_ID":"CO-ADD:0283651",
    "INHIB_AVE":19.7,
    "SMILES":"S(=O)(=O)(c(ccc(c1C(=O)Nc2ccccc2C(O)=O)C)c1)N(CC3)CCO3",
    "HIT":0.0,
    "question":"Is S(=O)(=O)(c(ccc(c1C(=O)Nc2ccccc2C(O)=O)C)c1)N(CC3)CCO3 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":3047
  },
  {
    "COADD_ID":"CO-ADD:0294801",
    "INHIB_AVE":-6.31,
    "SMILES":"n(c1c(n2C)ccc(c1)NCc3n(C)c4c(cccc4)n3)c2C",
    "HIT":0.0,
    "question":"Can n(c1c(n2C)ccc(c1)NCc3n(C)c4c(cccc4)n3)c2C act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":74250
  },
  {
    "COADD_ID":"CO-ADD:0230045",
    "INHIB_AVE":5.86,
    "SMILES":"c1cc(ccc1\\C=N\\NC(N)=S)NCS(=O)(=O)[O-]",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1cc(ccc1\\C=N\\NC(N)=S)NCS(=O)(=O)[O-]?",
    "answer":"No",
    "_id":31837
  },
  {
    "COADD_ID":"CO-ADD:0166308",
    "INHIB_AVE":7.41,
    "SMILES":"C(=O)(C(NCCc1ccccc1F)=O)Nc2cccc(Cl)c2Cl",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C(=O)(C(NCCc1ccccc1F)=O)Nc2cccc(Cl)c2Cl?",
    "answer":"No",
    "_id":25443
  },
  {
    "COADD_ID":"CO-ADD:0227285",
    "INHIB_AVE":3.78,
    "SMILES":"C(CNc1cccc(cccc2)c12)(=O)N\\N=C\\C=C\\c3ccco3",
    "HIT":0.0,
    "question":"Does treatment with C(CNc1cccc(cccc2)c12)(=O)N\\N=C\\C=C\\c3ccco3 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":41137
  },
  {
    "COADD_ID":"CO-ADD:0235013",
    "INHIB_AVE":10.64,
    "SMILES":"C(=O)(Oc1ccc(cc1OC)\\C=N\\NC(CNC(=O)c2cccc(F)c2)=O)c3ccccc3Cl",
    "HIT":0.0,
    "question":"Does C(=O)(Oc1ccc(cc1OC)\\C=N\\NC(CNC(=O)c2cccc(F)c2)=O)c3ccccc3Cl demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":15382
  },
  {
    "COADD_ID":"CO-ADD:0250166",
    "INHIB_AVE":7.61,
    "SMILES":"S(c1ccccc1)(=O)(=O)N(c2ccc(c(Cl)c2)OC)CC(=O)N\\N=C\\c3cccs3",
    "HIT":0.0,
    "question":"Is S(c1ccccc1)(=O)(=O)N(c2ccc(c(Cl)c2)OC)CC(=O)N\\N=C\\c3cccs3 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":24639
  },
  {
    "COADD_ID":"CO-ADD:0293861",
    "INHIB_AVE":9.48,
    "SMILES":"c(c(C)c(s1)C)(C2=O)c1N=C(SCC(=O)NC(C)(C)C)N2c3ccccc3",
    "HIT":0.0,
    "question":"Does c(c(C)c(s1)C)(C2=O)c1N=C(SCC(=O)NC(C)(C)C)N2c3ccccc3 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":18485
  },
  {
    "COADD_ID":"CO-ADD:0164546",
    "INHIB_AVE":0.34,
    "SMILES":"CNC1=Nc2ccc(Cl)cc2C(c2ccccc2)=[N+]([O-])C1",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound CNC1=Nc2ccc(Cl)cc2C(c2ccccc2)=[N+]([O-])C1?",
    "answer":"No",
    "_id":56082
  },
  {
    "COADD_ID":"CO-ADD:0166060",
    "INHIB_AVE":85.55,
    "SMILES":"c1(c(C)cccc1C)OCC(=O)N\\N=C\\c(cc2)ccc2C(O)=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(c(C)cccc1C)OCC(=O)N\\N=C\\c(cc2)ccc2C(O)=O?",
    "answer":"No",
    "_id":394
  },
  {
    "COADD_ID":"CO-ADD:0228145",
    "INHIB_AVE":13.83,
    "SMILES":"c1(NCC(=O)N\\N=C\/c(cc2)ccc2Cl)c(Br)cc(cc1Br)Cl",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(NCC(=O)N\\N=C\/c(cc2)ccc2Cl)c(Br)cc(cc1Br)Cl?",
    "answer":"No",
    "_id":9294
  },
  {
    "COADD_ID":"CO-ADD:0250014",
    "INHIB_AVE":3.95,
    "SMILES":"c12n(ncn1N)c(nn2)SCC(=O)C3CC3",
    "HIT":0.0,
    "question":"Is c12n(ncn1N)c(nn2)SCC(=O)C3CC3 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":40374
  },
  {
    "COADD_ID":"CO-ADD:0291294",
    "INHIB_AVE":4.5,
    "SMILES":"C1(Nc(cccc2C(F)(F)F)c2)(C(OC)=O)N(c3ccc(cc3)OCC)C(C(OC)=C1C(c4ccccc4)=O)=O",
    "HIT":0.0,
    "question":"Does treatment with C1(Nc(cccc2C(F)(F)F)c2)(C(OC)=O)N(c3ccc(cc3)OCC)C(C(OC)=C1C(c4ccccc4)=O)=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":37921
  },
  {
    "COADD_ID":"CO-ADD:0230568",
    "INHIB_AVE":-0.86,
    "SMILES":"C(CSc1ccccc1)(=O)N\\N=C\\c(cc2)ccc2N(C)c3ccccc3",
    "HIT":0.0,
    "question":"Does the proposed molecule C(CSc1ccccc1)(=O)N\\N=C\\c(cc2)ccc2N(C)c3ccccc3 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":60637
  },
  {
    "COADD_ID":"CO-ADD:0304156",
    "INHIB_AVE":29.06,
    "SMILES":"C(C(OC)=O)(=CN(Cc1cccs1)C=C2C(OC)=O)C2c3ccc(cc3)Cl",
    "HIT":0.0,
    "question":"Does the proposed molecule C(C(OC)=O)(=CN(Cc1cccs1)C=C2C(OC)=O)C2c3ccc(cc3)Cl exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":813
  },
  {
    "COADD_ID":"CO-ADD:0252253",
    "INHIB_AVE":4.76,
    "SMILES":"N1(C(c2ccc(cc2)F)CC(c3cccs3)=N1)c4scc(c5ccc(cc5)CC)n4.Br",
    "HIT":0.0,
    "question":"Is N1(C(c2ccc(cc2)F)CC(c3cccs3)=N1)c4scc(c5ccc(cc5)CC)n4.Br capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":36752
  },
  {
    "COADD_ID":"CO-ADD:0291088",
    "INHIB_AVE":2.5,
    "SMILES":"n1(Cc2ccccc2)c(S)nnc1c3ccc(c(OC)c3)OC",
    "HIT":0.0,
    "question":"Can n1(Cc2ccccc2)c(S)nnc1c3ccc(c(OC)c3)OC act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":46885
  },
  {
    "COADD_ID":"CO-ADD:0249209",
    "INHIB_AVE":-9.08,
    "SMILES":"S(=O)(=O)(c1ccc(cc1)C)Oc(cc2)ccc2\\C=C(\\C3=O)\/N=C(O3)c(cc4)ccc4C(C)(C)C",
    "HIT":0.0,
    "question":"Can S(=O)(=O)(c1ccc(cc1)C)Oc(cc2)ccc2\\C=C(\\C3=O)\/N=C(O3)c(cc4)ccc4C(C)(C)C effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":77936
  },
  {
    "COADD_ID":"CO-ADD:0250734",
    "INHIB_AVE":-2.33,
    "SMILES":"S(=O)(=O)(N(CC1)CCO1)c2c(Br)ccc(C(OC)=O)c2",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound S(=O)(=O)(N(CC1)CCO1)c2c(Br)ccc(C(OC)=O)c2?",
    "answer":"No",
    "_id":65368
  },
  {
    "COADD_ID":"CO-ADD:0245881",
    "INHIB_AVE":25.32,
    "SMILES":"S(N)(=O)(=O)c1ccc(cc1)NC(=S)NC(=O)\\C=C\\c2ccco2",
    "HIT":0.0,
    "question":"Is S(N)(=O)(=O)c1ccc(cc1)NC(=S)NC(=O)\\C=C\\c2ccco2 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":1118
  },
  {
    "COADD_ID":"CO-ADD:0149709",
    "INHIB_AVE":-0.93,
    "SMILES":"ClC(NC(OC)=C(C1C2=CC=CC=C2)C#N)=C1C=O",
    "HIT":0.0,
    "question":"Is ClC(NC(OC)=C(C1C2=CC=CC=C2)C#N)=C1C=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":60893
  },
  {
    "COADD_ID":"CO-ADD:0221074",
    "INHIB_AVE":7.59,
    "SMILES":"C(=N\\NC(COc1ccc(cc1OC)Br)=O)(\/c2c(N3)cccc2)\\C3=O",
    "HIT":0.0,
    "question":"Does C(=N\\NC(COc1ccc(cc1OC)Br)=O)(\/c2c(N3)cccc2)\\C3=O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":24705
  },
  {
    "COADD_ID":"CO-ADD:0326670",
    "INHIB_AVE":4.27,
    "SMILES":"c1(c2c3ccc(cccc4)c24)c(CC(C)CC1)c(n3)c5ccc(cc5)OCc6ccccc6F",
    "HIT":0.0,
    "question":"Can c1(c2c3ccc(cccc4)c24)c(CC(C)CC1)c(n3)c5ccc(cc5)OCc6ccccc6F effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":38937
  },
  {
    "COADD_ID":"CO-ADD:0305048",
    "INHIB_AVE":9.35,
    "SMILES":"[C@@H]1(Oc(cc2)ccc2\\C=N\\NC(c(cc3)ccn3)=O)O[C@H](CO)[C@H]([C@H](O)[C@H]1O)O",
    "HIT":0.0,
    "question":"Does [C@@H]1(Oc(cc2)ccc2\\C=N\\NC(c(cc3)ccn3)=O)O[C@H](CO)[C@H]([C@H](O)[C@H]1O)O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":18879
  },
  {
    "COADD_ID":"CO-ADD:0277777",
    "INHIB_AVE":-10.59,
    "SMILES":"C1(C(OCC)=O)=C(C)NC(=O)CC1c2ccc(c(Cl)c2)Cl",
    "HIT":0.0,
    "question":"Can C1(C(OCC)=O)=C(C)NC(=O)CC1c2ccc(c(Cl)c2)Cl act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":79136
  },
  {
    "COADD_ID":"CO-ADD:0300757",
    "INHIB_AVE":-11.79,
    "SMILES":"C12=C(CCCC1=O)NN=C(c3ccccc3)CC2c(cc4)ccc4[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Does treatment with C12=C(CCCC1=O)NN=C(c3ccccc3)CC2c(cc4)ccc4[N+](=O)[O-] result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":79906
  },
  {
    "COADD_ID":"CO-ADD:0302478",
    "INHIB_AVE":5.42,
    "SMILES":"n1(C(=O)\\C(\\S2)=N\\Nc(cc3)ccc3OC)c2nc(c4ccccc4)c1c5ccccc5",
    "HIT":0.0,
    "question":"Does n1(C(=O)\\C(\\S2)=N\\Nc(cc3)ccc3OC)c2nc(c4ccccc4)c1c5ccccc5 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":33825
  },
  {
    "COADD_ID":"CO-ADD:0157086",
    "INHIB_AVE":-13.17,
    "SMILES":"N#CC1=C(S\/C2=C\\C3=CC=CS3)N(C2=O)C(N)=C(C#N)C1C4=CC=CS4",
    "HIT":0.0,
    "question":"Can exposure to N#CC1=C(S\/C2=C\\C3=CC=CS3)N(C2=O)C(N)=C(C#N)C1C4=CC=CS4 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":80598
  },
  {
    "COADD_ID":"CO-ADD:0295302",
    "INHIB_AVE":1.78,
    "SMILES":"C(=C\\NCCCCCC)(\/C1=O)\\C(=O)NC(=O)N1",
    "HIT":0.0,
    "question":"Can C(=C\\NCCCCCC)(\/C1=O)\\C(=O)NC(=O)N1 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":50088
  },
  {
    "COADD_ID":"CO-ADD:0285521",
    "INHIB_AVE":4.67,
    "SMILES":"N1(c2cccc(c2)C(=O)NC(C)(C)C)C(=O)c(c3C1=O)ccc(C(O)=O)c3",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound N1(c2cccc(c2)C(=O)NC(C)(C)C)C(=O)c(c3C1=O)ccc(C(O)=O)c3?",
    "answer":"No",
    "_id":37143
  },
  {
    "COADD_ID":"CO-ADD:0301371",
    "INHIB_AVE":5.44,
    "SMILES":"c1(nc(c2)c(n3)cc(C#N)c2C#N)c3c4c(c(ccc5)ccc4)c15",
    "HIT":0.0,
    "question":"Is c1(nc(c2)c(n3)cc(C#N)c2C#N)c3c4c(c(ccc5)ccc4)c15 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":33736
  },
  {
    "COADD_ID":"CO-ADD:0240125",
    "INHIB_AVE":0.15,
    "SMILES":"C(=O)(N\\N=C\\c(ccc(c1OC)OC)c1)C(O)(c2ccccc2)c3ccccc3",
    "HIT":0.0,
    "question":"Can C(=O)(N\\N=C\\c(ccc(c1OC)OC)c1)C(O)(c2ccccc2)c3ccccc3 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":56889
  },
  {
    "COADD_ID":"CO-ADD:0283112",
    "INHIB_AVE":2.52,
    "SMILES":"c1(C(OCC)=O)c(cc(O)c(c2)Br)c2n(C3CCCCC3)c1CN4CCCCC4",
    "HIT":0.0,
    "question":"Can exposure to c1(C(OCC)=O)c(cc(O)c(c2)Br)c2n(C3CCCCC3)c1CN4CCCCC4 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":46762
  },
  {
    "COADD_ID":"CO-ADD:0243669",
    "INHIB_AVE":5.19,
    "SMILES":"C1(SC(C)=NC(N(C2CCCCC2)NC3=O)=C13)c4cc(c5c(c4OC)OCO5)OC",
    "HIT":0.0,
    "question":"Does C1(SC(C)=NC(N(C2CCCCC2)NC3=O)=C13)c4cc(c5c(c4OC)OCO5)OC show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":34791
  },
  {
    "COADD_ID":"CO-ADD:0319144",
    "INHIB_AVE":28.18,
    "SMILES":"C(C(F)(F)F)(C(F)(F)F)(NC(=O)c1ccc(cc1)F)N2CCCCC2c(cccn3)c3",
    "HIT":0.0,
    "question":"Does the proposed molecule C(C(F)(F)F)(C(F)(F)F)(NC(=O)c1ccc(cc1)F)N2CCCCC2c(cccn3)c3 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":863
  },
  {
    "COADD_ID":"CO-ADD:0221673",
    "INHIB_AVE":11.55,
    "SMILES":"C(OCCF)(NCCCCCCNC(OCCF)=O)=O",
    "HIT":0.0,
    "question":"Does treatment with C(OCCF)(NCCCCCCNC(OCCF)=O)=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":13349
  },
  {
    "COADD_ID":"CO-ADD:0321373",
    "INHIB_AVE":12.15,
    "SMILES":"N1(c2ccc(cc2)F)C(=O)C(N(CCc(cc3)ccc3OC)C1=S)CC(=O)Nc(cc4)ccc4OC(F)(Cl)F",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound N1(c2ccc(cc2)F)C(=O)C(N(CCc(cc3)ccc3OC)C1=S)CC(=O)Nc(cc4)ccc4OC(F)(Cl)F?",
    "answer":"No",
    "_id":12173
  },
  {
    "COADD_ID":"CO-ADD:0244855",
    "INHIB_AVE":4.93,
    "SMILES":"C(N(CC)C(=O)N1CC)(C1N2)N=C3N2C(=O)\\C(=C\\c(c(Cl)cc(Cl)c4)c4)\\S3",
    "HIT":0.0,
    "question":"Is C(N(CC)C(=O)N1CC)(C1N2)N=C3N2C(=O)\\C(=C\\c(c(Cl)cc(Cl)c4)c4)\\S3 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":35960
  },
  {
    "COADD_ID":"CO-ADD:0285159",
    "INHIB_AVE":6.08,
    "SMILES":"C1(SCC(=O)Nc(cc2)ccc2C)=NC(c3ccccc3)CC(=O)N1",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C1(SCC(=O)Nc(cc2)ccc2C)=NC(c3ccccc3)CC(=O)N1?",
    "answer":"No",
    "_id":30908
  },
  {
    "COADD_ID":"CO-ADD:0319182",
    "INHIB_AVE":-1.68,
    "SMILES":"c1(NC(COc(cc2)ccc2I)=O)sc(c(C)c1C(OCC)=O)C(OCC)=O",
    "HIT":0.0,
    "question":"Can c1(NC(COc(cc2)ccc2I)=O)sc(c(C)c1C(OCC)=O)C(OCC)=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":63355
  },
  {
    "COADD_ID":"CO-ADD:0217586",
    "INHIB_AVE":0.3,
    "SMILES":"s1c(\\C=N\\NC(COc(ccc(c2C)C)c2)=O)ccc1Br",
    "HIT":0.0,
    "question":"Does treatment with s1c(\\C=N\\NC(COc(ccc(c2C)C)c2)=O)ccc1Br result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":56228
  },
  {
    "COADD_ID":"CO-ADD:0302489",
    "INHIB_AVE":3.31,
    "SMILES":"c1(\\C=N\\NC(c2ccccc2)=O)cc(Br)ccc1O",
    "HIT":0.0,
    "question":"Does the proposed molecule c1(\\C=N\\NC(c2ccccc2)=O)cc(Br)ccc1O exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":43218
  },
  {
    "COADD_ID":"CO-ADD:0328467",
    "INHIB_AVE":4.33,
    "SMILES":"N1(CC(C)=C(CC1(C(OC)=O)C(F)(F)F)C)S(c2ccccc2)(=O)=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound N1(CC(C)=C(CC1(C(OC)=O)C(F)(F)F)C)S(c2ccccc2)(=O)=O?",
    "answer":"No",
    "_id":38680
  },
  {
    "COADD_ID":"CO-ADD:0329570",
    "INHIB_AVE":4.08,
    "SMILES":"S(=O)(=O)(c1ccc(cc1)OCC)NC(c(cccc2[N+](=O)[O-])c2)CC(OCC)=O",
    "HIT":0.0,
    "question":"Can S(=O)(=O)(c1ccc(cc1)OCC)NC(c(cccc2[N+](=O)[O-])c2)CC(OCC)=O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":39768
  },
  {
    "COADD_ID":"CO-ADD:0284271",
    "INHIB_AVE":19.59,
    "SMILES":"C(=N\\c1ccccc1)(\/S\\C(\\C2=O)=C\\c(ccc(c3OC)OCc4ccccc4Cl)c3)\\N2C5CCCCC5",
    "HIT":0.0,
    "question":"Is C(=N\\c1ccccc1)(\/S\\C(\\C2=O)=C\\c(ccc(c3OC)OCc4ccccc4Cl)c3)\\N2C5CCCCC5 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":3115
  },
  {
    "COADD_ID":"CO-ADD:0301681",
    "INHIB_AVE":12.78,
    "SMILES":"C(=O)(N1CCC(CC1)C)c2ccccc2NC(=O)c3ccc(cc3)C",
    "HIT":0.0,
    "question":"Does C(=O)(N1CCC(CC1)C)c2ccccc2NC(=O)c3ccc(cc3)C show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":10973
  },
  {
    "COADD_ID":"CO-ADD:0160432",
    "INHIB_AVE":-2.3,
    "SMILES":"O=C(C(C=C1)=CC=C1C#CC2=CC=CC=C2)C(C(C=C3)=CC=C3C#CC4=CC=CC=C4)=O",
    "HIT":0.0,
    "question":"Can O=C(C(C=C1)=CC=C1C#CC2=CC=CC=C2)C(C(C=C3)=CC=C3C#CC4=CC=CC=C4)=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":65277
  },
  {
    "COADD_ID":"CO-ADD:0148860",
    "INHIB_AVE":4.03,
    "SMILES":"c1(C(=O)c2cc(OC)ccc2OC)oc(c3c1N)cccc3",
    "HIT":0.0,
    "question":"Does c1(C(=O)c2cc(OC)ccc2OC)oc(c3c1N)cccc3 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":40054
  },
  {
    "COADD_ID":"CO-ADD:0157747",
    "INHIB_AVE":2.89,
    "SMILES":"OC1=C2N=CC=CC2=C(COC)C=C1CN3CCC(C)CC3",
    "HIT":0.0,
    "question":"Can OC1=C2N=CC=CC2=C(COC)C=C1CN3CCC(C)CC3 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":45151
  },
  {
    "COADD_ID":"CO-ADD:0254075",
    "INHIB_AVE":-1.3,
    "SMILES":"C(C(OC)=O)(C1c2ccc(cc2)Br)=C(N)N(C(CC(C)(C)CC3=O)=C13)c(cc4)ccc4S(N)(=O)=O",
    "HIT":0.0,
    "question":"Can C(C(OC)=O)(C1c2ccc(cc2)Br)=C(N)N(C(CC(C)(C)CC3=O)=C13)c(cc4)ccc4S(N)(=O)=O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":62081
  },
  {
    "COADD_ID":"CO-ADD:0247754",
    "INHIB_AVE":-9.49,
    "SMILES":"c1(c(Cl)cc(c(F)c1)F)NC(NCCCCCCCCCCCCCCCCCC)=O",
    "HIT":0.0,
    "question":"Does c1(c(Cl)cc(c(F)c1)F)NC(NCCCCCCCCCCCCCCCCCC)=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":78306
  },
  {
    "COADD_ID":"CO-ADD:0299709",
    "INHIB_AVE":1.78,
    "SMILES":"n12c(nnc1CC(OCC)=O)c(nc(non3)c23)Nc4ccccc4C",
    "HIT":0.0,
    "question":"Is n12c(nnc1CC(OCC)=O)c(nc(non3)c23)Nc4ccccc4C capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":50077
  },
  {
    "COADD_ID":"CO-ADD:0158661",
    "INHIB_AVE":-7.51,
    "SMILES":"CC1=CC=C(C)C=C1NC2=NC(N\/N=C\/C3=CC=C(C(OC)=C3)OC)=NC(N4CCOCC4)=N2",
    "HIT":0.0,
    "question":"Is CC1=CC=C(C)C=C1NC2=NC(N\/N=C\/C3=CC=C(C(OC)=C3)OC)=NC(N4CCOCC4)=N2 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":76075
  },
  {
    "COADD_ID":"CO-ADD:0149880",
    "INHIB_AVE":53.89,
    "SMILES":"O=C1C(C(O)C)C2N1C(C(NC3=CC=C(C(O4)=NNC4=S)C=C3)=O)=C(SC5CC(C(N(C)C)=O)NC5)C2C.Cl",
    "HIT":1.0,
    "question":"Does O=C1C(C(O)C)C2N1C(C(NC3=CC=C(C(O4)=NNC4=S)C=C3)=O)=C(SC5CC(C(N(C)C)=O)NC5)C2C.Cl demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"Yes",
    "_id":85
  },
  {
    "COADD_ID":"CO-ADD:0222301",
    "INHIB_AVE":3.83,
    "SMILES":"c1(c2ccc(cc2)\\N=C\\c3c(O)cc(c(Cl)c3C)C)sc(c4n1)cccc4",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(c2ccc(cc2)\\N=C\\c3c(O)cc(c(Cl)c3C)C)sc(c4n1)cccc4?",
    "answer":"No",
    "_id":40942
  },
  {
    "COADD_ID":"CO-ADD:0303272",
    "INHIB_AVE":9.28,
    "SMILES":"S(C)(=O)(=O)N(CC1)CCN1c2ccc(cc2[N+](=O)[O-])Cl",
    "HIT":0.0,
    "question":"Does the proposed molecule S(C)(=O)(=O)N(CC1)CCN1c2ccc(cc2[N+](=O)[O-])Cl exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":19109
  },
  {
    "COADD_ID":"CO-ADD:0284146",
    "INHIB_AVE":9.82,
    "SMILES":"c1(C(c2ccccc2)N(CC3)CCO3)nnnn1c4ccccc4",
    "HIT":0.0,
    "question":"Does treatment with c1(C(c2ccccc2)N(CC3)CCO3)nnnn1c4ccccc4 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":17522
  },
  {
    "COADD_ID":"CO-ADD:0299693",
    "INHIB_AVE":4.6,
    "SMILES":"c1(NC(N)=S)sc(c(C)c1C(OCC)=O)C",
    "HIT":0.0,
    "question":"Can exposure to c1(NC(N)=S)sc(c(C)c1C(OCC)=O)C lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":37450
  },
  {
    "COADD_ID":"CO-ADD:0149834",
    "INHIB_AVE":-2.43,
    "SMILES":"NC(C(C#N)=C1)=NC(N(C)C)=C1C#N.Cl",
    "HIT":0.0,
    "question":"Does NC(C(C#N)=C1)=NC(N(C)C)=C1C#N.Cl demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":65637
  },
  {
    "COADD_ID":"CO-ADD:0300018",
    "INHIB_AVE":-10.7,
    "SMILES":"c1(n(CCCC#N)c2c(cccc2)n1)c3nonc3NC(C)=O",
    "HIT":0.0,
    "question":"Is c1(n(CCCC#N)c2c(cccc2)n1)c3nonc3NC(C)=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":79207
  },
  {
    "COADD_ID":"CO-ADD:0157034",
    "INHIB_AVE":8.14,
    "SMILES":"N#CC1=C(SCC(NC2=NC(C)=CS2)=O)N=C(C3=CC=CS3)C=C1C4=CC=CS4",
    "HIT":0.0,
    "question":"Does treatment with N#CC1=C(SCC(NC2=NC(C)=CS2)=O)N=C(C3=CC=CS3)C=C1C4=CC=CS4 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":22682
  },
  {
    "COADD_ID":"CO-ADD:0286784",
    "INHIB_AVE":-4.38,
    "SMILES":"N1=C(c2ccccc2)c(cccc3)c3C(=O)N1CCOC(C)=O",
    "HIT":0.0,
    "question":"Can N1=C(c2ccccc2)c(cccc3)c3C(=O)N1CCOC(C)=O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":70585
  },
  {
    "COADD_ID":"CO-ADD:0287308",
    "INHIB_AVE":5.98,
    "SMILES":"C(=S)(c1ccc(cc1)OC)N2CCC(CC2)C",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C(=S)(c1ccc(cc1)OC)N2CCC(CC2)C?",
    "answer":"No",
    "_id":31355
  },
  {
    "COADD_ID":"CO-ADD:0302868",
    "INHIB_AVE":-1.55,
    "SMILES":"C12=C(CC(C)(C)CC1=O)Oc(c3C2C4C(=O)CC(CC4=O)(C)C)ccc(c3)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Can exposure to C12=C(CC(C)(C)CC1=O)Oc(c3C2C4C(=O)CC(CC4=O)(C)C)ccc(c3)[N+](=O)[O-] lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":62910
  },
  {
    "COADD_ID":"CO-ADD:0154517",
    "INHIB_AVE":0.2,
    "SMILES":"CC(C)NNC(CC1=CNC2=CC=CC=C21)=O",
    "HIT":0.0,
    "question":"Does CC(C)NNC(CC1=CNC2=CC=CC=C21)=O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":56683
  },
  {
    "COADD_ID":"CO-ADD:0257581",
    "INHIB_AVE":-8.83,
    "SMILES":"N1(c2ccc(c(C)c2)C)C(=O)\\C(=C\\c3cc(Br)cc(I)c3O)\\C(NC1=S)=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound N1(c2ccc(c(C)c2)C)C(=O)\\C(=C\\c3cc(Br)cc(I)c3O)\\C(NC1=S)=O?",
    "answer":"No",
    "_id":77663
  },
  {
    "COADD_ID":"CO-ADD:0284276",
    "INHIB_AVE":7.65,
    "SMILES":"C(=N\\c1ccccc1)(\/S\\C(\\C2=O)=C\\c(cc3OC)cc(c3OCc4ccc(cc4Cl)Cl)I)\\N2C5CCCCC5",
    "HIT":0.0,
    "question":"Can C(=N\\c1ccccc1)(\/S\\C(\\C2=O)=C\\c(cc3OC)cc(c3OCc4ccc(cc4Cl)Cl)I)\\N2C5CCCCC5 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":24478
  },
  {
    "COADD_ID":"CO-ADD:0217257",
    "INHIB_AVE":6.57,
    "SMILES":"c(cc(cccc1C)c1n2)(C(=O)N\\N=C(\/C)\\CC(=O)Nc3ccccc3CC)c2C",
    "HIT":0.0,
    "question":"Is c(cc(cccc1C)c1n2)(C(=O)N\\N=C(\/C)\\CC(=O)Nc3ccccc3CC)c2C capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":28828
  },
  {
    "COADD_ID":"CO-ADD:0241444",
    "INHIB_AVE":-7.85,
    "SMILES":"n1(c2c(n3)cccc2)c3S\\C(=C\/c4cccc(cccc5)c45)\\C1=O",
    "HIT":0.0,
    "question":"Can n1(c2c(n3)cccc2)c3S\\C(=C\/c4cccc(cccc5)c45)\\C1=O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":76540
  },
  {
    "COADD_ID":"CO-ADD:0222668",
    "INHIB_AVE":4.98,
    "SMILES":"N(\\C(=C\\c(ccc(c1OC)OC)c1)\\C(O2)=O)=C2C(C)(C)C",
    "HIT":0.0,
    "question":"Does treatment with N(\\C(=C\\c(ccc(c1OC)OC)c1)\\C(O2)=O)=C2C(C)(C)C result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":35709
  },
  {
    "COADD_ID":"CO-ADD:0312552",
    "INHIB_AVE":6.85,
    "SMILES":"C1([C@H]([C@H](C2CN3c4ccccc4)C3=O)C(O)=O)C(=C2)SC=C1",
    "HIT":0.0,
    "question":"Can exposure to C1([C@H]([C@H](C2CN3c4ccccc4)C3=O)C(O)=O)C(=C2)SC=C1 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":27626
  },
  {
    "COADD_ID":"CO-ADD:0225347",
    "INHIB_AVE":5.07,
    "SMILES":"c12n(ccn(nc(c3ccc(cc3)OCCCC)c4)c14)c(nn2)SCC(=O)Nc(cc5)ccc5CC",
    "HIT":0.0,
    "question":"Is c12n(ccn(nc(c3ccc(cc3)OCCCC)c4)c14)c(nn2)SCC(=O)Nc(cc5)ccc5CC effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":35338
  },
  {
    "COADD_ID":"CO-ADD:0326780",
    "INHIB_AVE":4.07,
    "SMILES":"c1(n2)c(C(N(C)C(=O)N1C)=O)n(c23)CCN3c4ccc(cc4)OC",
    "HIT":0.0,
    "question":"Does treatment with c1(n2)c(C(N(C)C(=O)N1C)=O)n(c23)CCN3c4ccc(cc4)OC result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":39851
  },
  {
    "COADD_ID":"CO-ADD:0217580",
    "INHIB_AVE":9.72,
    "SMILES":"C(=O)(N\\N=C\\c1cccc(Cl)c1Cl)C(C)Oc(ccc(c23)cccc2)c3",
    "HIT":0.0,
    "question":"Is C(=O)(N\\N=C\\c1cccc(Cl)c1Cl)C(C)Oc(ccc(c23)cccc2)c3 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":17809
  },
  {
    "COADD_ID":"CO-ADD:0245344",
    "INHIB_AVE":7.91,
    "SMILES":"n1(c2c(n3)cccc2)c3S\\C(=C\/c(ccc4c5ccc(cc5)Br)o4)\\C1=O",
    "HIT":0.0,
    "question":"Can exposure to n1(c2c(n3)cccc2)c3S\\C(=C\/c(ccc4c5ccc(cc5)Br)o4)\\C1=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":23535
  },
  {
    "COADD_ID":"CO-ADD:0243289",
    "INHIB_AVE":1.73,
    "SMILES":"c(CC(C1)ON=C1C(NN)=O)(c(OC)c2OC)c(Br)c(c23)OCO3",
    "HIT":0.0,
    "question":"Is c(CC(C1)ON=C1C(NN)=O)(c(OC)c2OC)c(Br)c(c23)OCO3 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":50293
  },
  {
    "COADD_ID":"CO-ADD:0229488",
    "INHIB_AVE":3.0,
    "SMILES":"N1(c2ccc(c(C)c2)C)C(=O)\\C(\\C(C)=N1)=C\/Nc(cc3)ccc3C(C)=O",
    "HIT":0.0,
    "question":"Can exposure to N1(c2ccc(c(C)c2)C)C(=O)\\C(\\C(C)=N1)=C\/Nc(cc3)ccc3C(C)=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":44675
  },
  {
    "COADD_ID":"CO-ADD:0229359",
    "INHIB_AVE":5.08,
    "SMILES":"c1(N\\N=C\\c2cc(Br)ccc2O)sc(c3n1)cccc3",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(N\\N=C\\c2cc(Br)ccc2O)sc(c3n1)cccc3?",
    "answer":"No",
    "_id":35303
  },
  {
    "COADD_ID":"CO-ADD:0240691",
    "INHIB_AVE":20.32,
    "SMILES":"C(Cl)(Cl)(Cl)C(O)CC(c1ccccc1)=O",
    "HIT":0.0,
    "question":"Can C(Cl)(Cl)(Cl)C(O)CC(c1ccccc1)=O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":2684
  },
  {
    "COADD_ID":"CO-ADD:0278077",
    "INHIB_AVE":19.71,
    "SMILES":"C(\/c1c2cccc1)(=C(\/C#N)\\C(OCC)=O)\\C(Cl)=C2Cl",
    "HIT":0.0,
    "question":"Can exposure to C(\/c1c2cccc1)(=C(\/C#N)\\C(OCC)=O)\\C(Cl)=C2Cl lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":3042
  },
  {
    "COADD_ID":"CO-ADD:0223450",
    "INHIB_AVE":4.83,
    "SMILES":"C(=C\/c(cc1)ccc1OCCC)(\/NC(c2ccccc2)=O)\\C(=O)N\\N=C\\c3cccc(OC)c3",
    "HIT":0.0,
    "question":"Can C(=C\/c(cc1)ccc1OCCC)(\/NC(c2ccccc2)=O)\\C(=O)N\\N=C\\c3cccc(OC)c3 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":36397
  },
  {
    "COADD_ID":"CO-ADD:0252610",
    "INHIB_AVE":2.64,
    "SMILES":"C12(c3c(C(c4ccccc4)(c5ccccc5)N1c6ccccc6)cccc3)SC(=NN2c7ccccc7)C(C)=O",
    "HIT":0.0,
    "question":"Can C12(c3c(C(c4ccccc4)(c5ccccc5)N1c6ccccc6)cccc3)SC(=NN2c7ccccc7)C(C)=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":46255
  },
  {
    "COADD_ID":"CO-ADD:0237183",
    "INHIB_AVE":-4.85,
    "SMILES":"Clc1ccc(cc1)S(=O)(=O)N2CCN(CC2)C(=S)NCc3occc3",
    "HIT":0.0,
    "question":"Is Clc1ccc(cc1)S(=O)(=O)N2CCN(CC2)C(=S)NCc3occc3 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":71551
  },
  {
    "COADD_ID":"CO-ADD:0243927",
    "INHIB_AVE":14.56,
    "SMILES":"CCOc1cc(CCNC(=O)CC(c(cc(OCO2)c23)cc3OC)C(C(=O)OC(C)=C4)=C4O)ccc1OCC",
    "HIT":0.0,
    "question":"Does CCOc1cc(CCNC(=O)CC(c(cc(OCO2)c23)cc3OC)C(C(=O)OC(C)=C4)=C4O)ccc1OCC demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":8175
  },
  {
    "COADD_ID":"CO-ADD:0283316",
    "INHIB_AVE":-4.33,
    "SMILES":"n12c(ccc(cccc3)c13)nnc2c4ccc(cc4)Br",
    "HIT":0.0,
    "question":"Is n12c(ccc(cccc3)c13)nnc2c4ccc(cc4)Br capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":70482
  },
  {
    "COADD_ID":"CO-ADD:0232444",
    "INHIB_AVE":15.05,
    "SMILES":"c1(c(O)c(\\C=N\\c(cc2)ccc2c3oc(c4n3)cccc4C)c(c(Cl)c1C)C)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Does treatment with c1(c(O)c(\\C=N\\c(cc2)ccc2c3oc(c4n3)cccc4C)c(c(Cl)c1C)C)[N+](=O)[O-] result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":7530
  },
  {
    "COADD_ID":"CO-ADD:0258306",
    "INHIB_AVE":14.46,
    "SMILES":"c1(SC)nc(c2n1CC(=O)Nc3c(C)cccc3C)cccc2",
    "HIT":0.0,
    "question":"Does the proposed molecule c1(SC)nc(c2n1CC(=O)Nc3c(C)cccc3C)cccc2 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":8313
  },
  {
    "COADD_ID":"CO-ADD:0148642",
    "INHIB_AVE":4.95,
    "SMILES":"[se]1c2c(NC(=O)CC2c3c(OC)c(OC)c(OCO4)c4c3)nc1N",
    "HIT":0.0,
    "question":"Is [se]1c2c(NC(=O)CC2c3c(OC)c(OC)c(OCO4)c4c3)nc1N capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":35846
  },
  {
    "COADD_ID":"CO-ADD:0242548",
    "INHIB_AVE":7.9,
    "SMILES":"c1(sc(c(c(cc2)ccc2c3ccccc3)n1)C)NC(=O)c(cccn4)c4",
    "HIT":0.0,
    "question":"Does c1(sc(c(c(cc2)ccc2c3ccccc3)n1)C)NC(=O)c(cccn4)c4 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":23588
  },
  {
    "COADD_ID":"CO-ADD:0323192",
    "INHIB_AVE":-6.72,
    "SMILES":"N1(c2ccc(cc2)OCCC)C(=O)CC(N(CCC(C3)(CC(C4)CC5CC34)C5)C(C)=O)C1=O",
    "HIT":0.0,
    "question":"Does treatment with N1(c2ccc(cc2)OCCC)C(=O)CC(N(CCC(C3)(CC(C4)CC5CC34)C5)C(C)=O)C1=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":74915
  },
  {
    "COADD_ID":"CO-ADD:0255437",
    "INHIB_AVE":1.26,
    "SMILES":"s1c(N)nnc1SCC(=O)Nc(cc2)ccc2NC(C)=O",
    "HIT":0.0,
    "question":"Can s1c(N)nnc1SCC(=O)Nc(cc2)ccc2NC(C)=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":52330
  },
  {
    "COADD_ID":"CO-ADD:0226238",
    "INHIB_AVE":7.6,
    "SMILES":"S(=O)(=O)(N(Cc(cc1F)cc(c1)F)c2ccc(c3c2)OCO3)c(ccc(n4c5)nn5)c4",
    "HIT":0.0,
    "question":"Can S(=O)(=O)(N(Cc(cc1F)cc(c1)F)c2ccc(c3c2)OCO3)c(ccc(n4c5)nn5)c4 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":24697
  },
  {
    "COADD_ID":"CO-ADD:0294650",
    "INHIB_AVE":1.86,
    "SMILES":"n1c2c([nH]c1SCC(O)=O)cc(C)cc2C",
    "HIT":0.0,
    "question":"Does the proposed molecule n1c2c([nH]c1SCC(O)=O)cc(C)cc2C exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":49721
  },
  {
    "COADD_ID":"CO-ADD:0295653",
    "INHIB_AVE":14.09,
    "SMILES":"c12c(c3c(CCCC3)s1)c(nc(c4cccc(OC)c4)n2)O",
    "HIT":0.0,
    "question":"Can exposure to c12c(c3c(CCCC3)s1)c(nc(c4cccc(OC)c4)n2)O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":8895
  },
  {
    "COADD_ID":"CO-ADD:0283371",
    "INHIB_AVE":-4.31,
    "SMILES":"c1(C(=O)c2ccc(cc2)F)coc(ccc(O)c3CN(C)C)c13",
    "HIT":0.0,
    "question":"Does c1(C(=O)c2ccc(cc2)F)coc(ccc(O)c3CN(C)C)c13 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":70428
  },
  {
    "COADD_ID":"CO-ADD:0293336",
    "INHIB_AVE":-2.82,
    "SMILES":"C(=C(C)NC(=C1C#N)SCC(=O)Nc2ccccc2C)(C(=O)Nc3ccccc3OC)C1c4ccccc4Cl",
    "HIT":0.0,
    "question":"Can C(=C(C)NC(=C1C#N)SCC(=O)Nc2ccccc2C)(C(=O)Nc3ccccc3OC)C1c4ccccc4Cl effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":66735
  },
  {
    "COADD_ID":"CO-ADD:0287670",
    "INHIB_AVE":3.34,
    "SMILES":"N1(c2ccc(c(Cl)c2)Cl)C(=O)\\C(\\SC1=O)=C\/c(cc3)ccc3OCc(cc4)ccc4F",
    "HIT":0.0,
    "question":"Can exposure to N1(c2ccc(c(Cl)c2)Cl)C(=O)\\C(\\SC1=O)=C\/c(cc3)ccc3OCc(cc4)ccc4F lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":43064
  },
  {
    "COADD_ID":"CO-ADD:0250367",
    "INHIB_AVE":-22.51,
    "SMILES":"c1(cc(ccc1N2CCCCC2)n3cnnn3)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Can c1(cc(ccc1N2CCCCC2)n3cnnn3)[N+](=O)[O-] act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":82353
  },
  {
    "COADD_ID":"CO-ADD:0163041",
    "INHIB_AVE":3.64,
    "SMILES":"N(c1ccccn1)C(CCCCC(=O)Nc2ccccn2)=O",
    "HIT":0.0,
    "question":"Is N(c1ccccn1)C(CCCCC(=O)Nc2ccccn2)=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":41791
  },
  {
    "COADD_ID":"CO-ADD:0226806",
    "INHIB_AVE":-5.02,
    "SMILES":"c1(C2=O)n(c3c(cccc3)N2CC(=O)Nc4cccc(SC)c4)c(nn1)C(C)C",
    "HIT":0.0,
    "question":"Can c1(C2=O)n(c3c(cccc3)N2CC(=O)Nc4cccc(SC)c4)c(nn1)C(C)C effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":71908
  },
  {
    "COADD_ID":"CO-ADD:0225210",
    "INHIB_AVE":18.93,
    "SMILES":"N1(c(cccc2)c2C(N3CCC(=O)NC4CCCCC4)=O)C3=NN(Cc5cccc(OC)c5)C1=O",
    "HIT":0.0,
    "question":"Is N1(c(cccc2)c2C(N3CCC(=O)NC4CCCCC4)=O)C3=NN(Cc5cccc(OC)c5)C1=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":3566
  },
  {
    "COADD_ID":"CO-ADD:0155184",
    "INHIB_AVE":-3.51,
    "SMILES":"O=C1OC(C2=CC=CC=C2F)=N\/C1=C\\C3=CC=C4C=CC=CC4=C3",
    "HIT":0.0,
    "question":"Does the proposed molecule O=C1OC(C2=CC=CC=C2F)=N\/C1=C\\C3=CC=C4C=CC=CC4=C3 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":68544
  },
  {
    "COADD_ID":"CO-ADD:0253880",
    "INHIB_AVE":-21.93,
    "SMILES":"c(c1c(s2)CCCC1)(C3=O)c2N=C(SCc4c(cccc4Cl)Cl)N3c5ccccc5",
    "HIT":0.0,
    "question":"Does the proposed molecule c(c1c(s2)CCCC1)(C3=O)c2N=C(SCc4c(cccc4Cl)Cl)N3c5ccccc5 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":82315
  },
  {
    "COADD_ID":"CO-ADD:0292100",
    "INHIB_AVE":0.49,
    "SMILES":"n1c2c(oc1c(ccc(c3NC(=O)c4cc(c5o4)cccc5)C)c3)cccn2",
    "HIT":0.0,
    "question":"Can n1c2c(oc1c(ccc(c3NC(=O)c4cc(c5o4)cccc5)C)c3)cccn2 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":55527
  },
  {
    "COADD_ID":"CO-ADD:0227003",
    "INHIB_AVE":2.95,
    "SMILES":"N12C(C=CC(SCc(cc3)ccc3Cl)=N1)=NN(CC(=O)Nc4c(CC)cccc4C)C2=O",
    "HIT":0.0,
    "question":"Is N12C(C=CC(SCc(cc3)ccc3Cl)=N1)=NN(CC(=O)Nc4c(CC)cccc4C)C2=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":44866
  },
  {
    "COADD_ID":"CO-ADD:0287722",
    "INHIB_AVE":-8.37,
    "SMILES":"n1c(c2ccc(cc2)CC)csc1N\\N=C(\\C)\/c3ccc(Br)s3.Br",
    "HIT":0.0,
    "question":"Is n1c(c2ccc(cc2)CC)csc1N\\N=C(\\C)\/c3ccc(Br)s3.Br effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":77162
  },
  {
    "COADD_ID":"CO-ADD:0253597",
    "INHIB_AVE":10.27,
    "SMILES":"c(cc(cc1C(=O)Nc2ccccc2)[N+](=O)[O-])([N+](=O)[O-])c1Nc(cc3)ccc3Oc4ccccc4",
    "HIT":0.0,
    "question":"Can c(cc(cc1C(=O)Nc2ccccc2)[N+](=O)[O-])([N+](=O)[O-])c1Nc(cc3)ccc3Oc4ccccc4 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":16301
  },
  {
    "COADD_ID":"CO-ADD:0234509",
    "INHIB_AVE":-4.83,
    "SMILES":"C1(=C(CC(C)(C)CC1=O)OC(=C23)CC(CC2=O)(C)C)C3c4ccccc4C(O)=O",
    "HIT":0.0,
    "question":"Does the proposed molecule C1(=C(CC(C)(C)CC1=O)OC(=C23)CC(CC2=O)(C)C)C3c4ccccc4C(O)=O exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":71506
  },
  {
    "COADD_ID":"CO-ADD:0306161",
    "INHIB_AVE":6.81,
    "SMILES":"C([C@@H](C)C)(C(SC[C@H](NC(=O)OCc(cc1)ccc1)C(=O)OC)C2)CC[C@H]2C",
    "HIT":0.0,
    "question":"Does C([C@@H](C)C)(C(SC[C@H](NC(=O)OCc(cc1)ccc1)C(=O)OC)C2)CC[C@H]2C demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":27770
  },
  {
    "COADD_ID":"CO-ADD:0225770",
    "INHIB_AVE":20.84,
    "SMILES":"C1(=N2)N(C=CN=C1SCc(cc3)ccc3Cl)C(N2CC(=O)Nc4ccc(cc4C)F)=O",
    "HIT":0.0,
    "question":"Can C1(=N2)N(C=CN=C1SCc(cc3)ccc3Cl)C(N2CC(=O)Nc4ccc(cc4C)F)=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":2414
  },
  {
    "COADD_ID":"CO-ADD:0220538",
    "INHIB_AVE":1.69,
    "SMILES":"c1(\\C=N\\NC(CNc2ccccc2C)=O)cc(Br)ccc1OC",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(\\C=N\\NC(CNc2ccccc2C)=O)cc(Br)ccc1OC?",
    "answer":"No",
    "_id":50461
  },
  {
    "COADD_ID":"CO-ADD:0305954",
    "INHIB_AVE":4.36,
    "SMILES":"c1(NC(COc(cccc2C(F)(F)F)c2)=O)sc(c(C)c1C(OC)=O)C",
    "HIT":0.0,
    "question":"Is c1(NC(COc(cccc2C(F)(F)F)c2)=O)sc(c(C)c1C(OC)=O)C capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":38565
  },
  {
    "COADD_ID":"CO-ADD:0311816",
    "INHIB_AVE":12.24,
    "SMILES":"C(C(OC)=O)(NC(C)=O)(C(F)(F)F)Nc1sc2c(CCC(C(C)(C)C)C2)c1C#N",
    "HIT":0.0,
    "question":"Can C(C(OC)=O)(NC(C)=O)(C(F)(F)F)Nc1sc2c(CCC(C(C)(C)C)C2)c1C#N effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":11987
  },
  {
    "COADD_ID":"CO-ADD:0156066",
    "INHIB_AVE":2.27,
    "SMILES":"O=C1\/C(N=C(C(C=C2)=CC=C2Cl)O1)=C\/C3=CC(OC)=C(OC)C(OC)=C3",
    "HIT":0.0,
    "question":"Does O=C1\/C(N=C(C(C=C2)=CC=C2Cl)O1)=C\/C3=CC(OC)=C(OC)C(OC)=C3 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":47919
  },
  {
    "COADD_ID":"CO-ADD:0320075",
    "INHIB_AVE":0.01,
    "SMILES":"c12c(ccc(C(=O)NCc3ccccc3)c1SCC)C(=O)c(c4C2=O)cccc4",
    "HIT":0.0,
    "question":"Can exposure to c12c(ccc(C(=O)NCc3ccccc3)c1SCC)C(=O)c(c4C2=O)cccc4 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":57400
  },
  {
    "COADD_ID":"CO-ADD:0284701",
    "INHIB_AVE":5.71,
    "SMILES":"c(cn(n1)Cc2c(cccc2Cl)Cl)(\\C=C(\\C#N)\/C(OCC)=O)c1c3ccccc3",
    "HIT":0.0,
    "question":"Does treatment with c(cn(n1)Cc2c(cccc2Cl)Cl)(\\C=C(\\C#N)\/C(OCC)=O)c1c3ccccc3 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":32483
  },
  {
    "COADD_ID":"CO-ADD:0301536",
    "INHIB_AVE":0.01,
    "SMILES":"c12c(C(N(C)C(=O)N1C)=O)n(c(N(CC3)CCO3)n2)CC(=O)c4ccc(cc4)Br",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c12c(C(N(C)C(=O)N1C)=O)n(c(N(CC3)CCO3)n2)CC(=O)c4ccc(cc4)Br?",
    "answer":"No",
    "_id":57413
  },
  {
    "COADD_ID":"CO-ADD:0148988",
    "INHIB_AVE":19.52,
    "SMILES":"n1c(c2ccc(c(OC)c2)OC)csc1Nc(cc3)ccc3OC",
    "HIT":0.0,
    "question":"Can n1c(c2ccc(c(OC)c2)OC)csc1Nc(cc3)ccc3OC act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":3160
  },
  {
    "COADD_ID":"CO-ADD:0292459",
    "INHIB_AVE":9.42,
    "SMILES":"C(C(OCC)=O)(C(c1ccccc1O)N2)=C(C)N(C2=O)C",
    "HIT":0.0,
    "question":"Does C(C(OCC)=O)(C(c1ccccc1O)N2)=C(C)N(C2=O)C show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":18691
  },
  {
    "COADD_ID":"CO-ADD:0323798",
    "INHIB_AVE":-11.33,
    "SMILES":"S(=O)(=O)(Oc1ccccc1F)NC(=O)Nc(cc2)ccc2OC(Cl)(F)F",
    "HIT":0.0,
    "question":"Can S(=O)(=O)(Oc1ccccc1F)NC(=O)Nc(cc2)ccc2OC(Cl)(F)F act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":79612
  },
  {
    "COADD_ID":"CO-ADD:0312522",
    "INHIB_AVE":-3.31,
    "SMILES":"c1(sccc1)S(N2C[C@](O[C@H]3C4)(C=C3)[C@@H]4C2)(=O)=O",
    "HIT":0.0,
    "question":"Does c1(sccc1)S(N2C[C@](O[C@H]3C4)(C=C3)[C@@H]4C2)(=O)=O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":68022
  },
  {
    "COADD_ID":"CO-ADD:0304114",
    "INHIB_AVE":6.82,
    "SMILES":"c(cc(C(=O)[O-])cc1[N+](=O)[O-])([N+](=O)[O-])c1N(CC2)CCN2c(cccc3C(F)(F)F)c3.O",
    "HIT":0.0,
    "question":"Is c(cc(C(=O)[O-])cc1[N+](=O)[O-])([N+](=O)[O-])c1N(CC2)CCN2c(cccc3C(F)(F)F)c3.O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":27745
  },
  {
    "COADD_ID":"CO-ADD:0236032",
    "INHIB_AVE":1.45,
    "SMILES":"c1(NC(=O)c2ccccc2I)sc(c3c1C#N)CCCC3",
    "HIT":0.0,
    "question":"Does c1(NC(=O)c2ccccc2I)sc(c3c1C#N)CCCC3 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":51517
  },
  {
    "COADD_ID":"CO-ADD:0301864",
    "INHIB_AVE":6.84,
    "SMILES":"c1(c2c(sc1NC(COc3ccc(cc3F)F)=O)CCC2)C(=O)OC(C)C",
    "HIT":0.0,
    "question":"Is c1(c2c(sc1NC(COc3ccc(cc3F)F)=O)CCC2)C(=O)OC(C)C effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":27650
  },
  {
    "COADD_ID":"CO-ADD:0243082",
    "INHIB_AVE":17.86,
    "SMILES":"c(C1C(C#N)=C(N)OC(CC2)=C1C(=O)C2)(c3OC)c(CC4CC(C(OCC)=O)=NO4)c(OC)c(OCO5)c35",
    "HIT":0.0,
    "question":"Can exposure to c(C1C(C#N)=C(N)OC(CC2)=C1C(=O)C2)(c3OC)c(CC4CC(C(OCC)=O)=NO4)c(OC)c(OCO5)c35 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":4435
  },
  {
    "COADD_ID":"CO-ADD:0293877",
    "INHIB_AVE":-0.68,
    "SMILES":"C(C(OCC)=O)(N(C)NC(N1c2ccccc2)c(cc3)ccc3[N+](=O)[O-])=N1",
    "HIT":0.0,
    "question":"Does treatment with C(C(OCC)=O)(N(C)NC(N1c2ccccc2)c(cc3)ccc3[N+](=O)[O-])=N1 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":60008
  },
  {
    "COADD_ID":"CO-ADD:0278315",
    "INHIB_AVE":-5.94,
    "SMILES":"c1(C(=O)NNC(Cc(cc2)ccc2Cl)=O)nn(cc1Br)C",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(C(=O)NNC(Cc(cc2)ccc2Cl)=O)nn(cc1Br)C?",
    "answer":"No",
    "_id":73611
  },
  {
    "COADD_ID":"CO-ADD:0277406",
    "INHIB_AVE":9.9,
    "SMILES":"C(=C\/c(ccc1c(cccc2C(F)(F)F)c2)o1)(\/C3=O)\\C(=O)NC(=S)N3",
    "HIT":0.0,
    "question":"Does C(=C\/c(ccc1c(cccc2C(F)(F)F)c2)o1)(\/C3=O)\\C(=O)NC(=S)N3 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":17260
  },
  {
    "COADD_ID":"CO-ADD:0136404",
    "INHIB_AVE":-6.89,
    "SMILES":"c1c(NC(=O)CN)c(C(c2[nH]ccc2)=O)cc(Cl)c1",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1c(NC(=O)CN)c(C(c2[nH]ccc2)=O)cc(Cl)c1?",
    "answer":"No",
    "_id":75164
  },
  {
    "COADD_ID":"CO-ADD:0221446",
    "INHIB_AVE":9.89,
    "SMILES":"S(=O)(=O)(Nc(cccc1[N+](=O)[O-])c1)c2cccc3c2cccc3S(=O)(=O)Nc(cccc4[N+](=O)[O-])c4",
    "HIT":0.0,
    "question":"Does treatment with S(=O)(=O)(Nc(cccc1[N+](=O)[O-])c1)c2cccc3c2cccc3S(=O)(=O)Nc(cccc4[N+](=O)[O-])c4 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":17284
  },
  {
    "COADD_ID":"CO-ADD:0256451",
    "INHIB_AVE":8.71,
    "SMILES":"c1(SCC(=O)Nc(ccc(c2s3)nc3SC)c2)[nH]c(c4n1)cccc4",
    "HIT":0.0,
    "question":"Does the proposed molecule c1(SCC(=O)Nc(ccc(c2s3)nc3SC)c2)[nH]c(c4n1)cccc4 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":20840
  },
  {
    "COADD_ID":"CO-ADD:0285125",
    "INHIB_AVE":-0.38,
    "SMILES":"c12c(nnc(SCC=C)n1)c3c(cccc3)n2CCc4ccccc4",
    "HIT":0.0,
    "question":"Is c12c(nnc(SCC=C)n1)c3c(cccc3)n2CCc4ccccc4 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":58913
  },
  {
    "COADD_ID":"CO-ADD:0283778",
    "INHIB_AVE":7.76,
    "SMILES":"N(CCN1C(CC)=O)(C1c2ccccc2)S(=O)(=O)c3ccc(cc3)C",
    "HIT":0.0,
    "question":"Does the proposed molecule N(CCN1C(CC)=O)(C1c2ccccc2)S(=O)(=O)c3ccc(cc3)C exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":24123
  },
  {
    "COADD_ID":"CO-ADD:0218926",
    "INHIB_AVE":7.45,
    "SMILES":"c1(c(C)cc(cc1C)C)NC(=O)C\\C(\\C)=N\\NC(=O)c2ccccc2F",
    "HIT":0.0,
    "question":"Does c1(c(C)cc(cc1C)C)NC(=O)C\\C(\\C)=N\\NC(=O)c2ccccc2F demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":25267
  },
  {
    "COADD_ID":"CO-ADD:0241378",
    "INHIB_AVE":-7.87,
    "SMILES":"c1([N+](=O)[O-])nnn(CC(=O)N(c2ccccc2)c3ccccc3)n1",
    "HIT":0.0,
    "question":"Does the proposed molecule c1([N+](=O)[O-])nnn(CC(=O)N(c2ccccc2)c3ccccc3)n1 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":76555
  },
  {
    "COADD_ID":"CO-ADD:0237425",
    "INHIB_AVE":-4.87,
    "SMILES":"Sc1nnc(NC(=O)c2cc(Br)ccc2Cl)s1",
    "HIT":0.0,
    "question":"Can exposure to Sc1nnc(NC(=O)c2cc(Br)ccc2Cl)s1 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":71600
  },
  {
    "COADD_ID":"CO-ADD:0245079",
    "INHIB_AVE":-7.74,
    "SMILES":"c1(SCC(=O)NCc2ccccc2)[nH]c(c3n1)ccc(OC)c3",
    "HIT":0.0,
    "question":"Does treatment with c1(SCC(=O)NCc2ccccc2)[nH]c(c3n1)ccc(OC)c3 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":76389
  },
  {
    "COADD_ID":"CO-ADD:0323983",
    "INHIB_AVE":-1.79,
    "SMILES":"S(NCCc(ccc(c1OCC)OCC)c1)(=O)(=O)c(cc2)ccc2[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Does S(NCCc(ccc(c1OCC)OCC)c1)(=O)(=O)c(cc2)ccc2[N+](=O)[O-] show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":63703
  },
  {
    "COADD_ID":"CO-ADD:0232907",
    "INHIB_AVE":-0.52,
    "SMILES":"c1(SCC(=O)Nc2ccccc2)sc3c(ccc(c3)NC(=O)c4ccccc4Cl)n1",
    "HIT":0.0,
    "question":"Does the proposed molecule c1(SCC(=O)Nc2ccccc2)sc3c(ccc(c3)NC(=O)c4ccccc4Cl)n1 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":59437
  },
  {
    "COADD_ID":"CO-ADD:0236595",
    "INHIB_AVE":3.86,
    "SMILES":"C(C#N)(=C(N)OC(=C12)CC(CC1=O)(C)C)C2c(cco3)c3",
    "HIT":0.0,
    "question":"Does C(C#N)(=C(N)OC(=C12)CC(CC1=O)(C)C)C2c(cco3)c3 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":40810
  },
  {
    "COADD_ID":"CO-ADD:0245821",
    "INHIB_AVE":4.91,
    "SMILES":"C(C)(CC(c(c12)cccc1)c(c34)cccc3)(C(=O)Nc(c(C)ccc5[N+](=O)[O-])c5)C24",
    "HIT":0.0,
    "question":"Can C(C)(CC(c(c12)cccc1)c(c34)cccc3)(C(=O)Nc(c(C)ccc5[N+](=O)[O-])c5)C24 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":36060
  },
  {
    "COADD_ID":"CO-ADD:0320676",
    "INHIB_AVE":-0.14,
    "SMILES":"[nH](c(ccc(c1)OC(F)(F)F)c1c2CCNC(=O)c3ccc(c(OC)c3)OC)c2C",
    "HIT":0.0,
    "question":"Can [nH](c(ccc(c1)OC(F)(F)F)c1c2CCNC(=O)c3ccc(c(OC)c3)OC)c2C effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":58017
  },
  {
    "COADD_ID":"CO-ADD:0243537",
    "INHIB_AVE":1.46,
    "SMILES":"c(C(CN)CC(O)=O)(c1)c(OC)c(OCO2)c2c1OC.Cl",
    "HIT":0.0,
    "question":"Is c(C(CN)CC(O)=O)(c1)c(OC)c(OCO2)c2c1OC.Cl effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":51480
  },
  {
    "COADD_ID":"CO-ADD:0220591",
    "INHIB_AVE":6.44,
    "SMILES":"c1(c(Br)cc(cc1\\C=N\\NC(COc2ccc(cc2Cl)Cl)=O)Br)OC(c3ccccc3)=O",
    "HIT":0.0,
    "question":"Can c1(c(Br)cc(cc1\\C=N\\NC(COc2ccc(cc2Cl)Cl)=O)Br)OC(c3ccccc3)=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":29357
  },
  {
    "COADD_ID":"CO-ADD:0331313",
    "INHIB_AVE":9.01,
    "SMILES":"C1(C(F)(F)F)(NC(=O)c2ccc(cc2)OC)C(=O)NC3=C1C(=O)NC(N3c4ccc(cc4)C)=O",
    "HIT":0.0,
    "question":"Does treatment with C1(C(F)(F)F)(NC(=O)c2ccc(cc2)OC)C(=O)NC3=C1C(=O)NC(N3c4ccc(cc4)C)=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":19876
  },
  {
    "COADD_ID":"CO-ADD:0163117",
    "INHIB_AVE":5.73,
    "SMILES":"N1(\\N=C\\c(ccc2Sc3cccc(cccn4)c34)o2)C(C)=Nc(c5C1=O)cccc5",
    "HIT":0.0,
    "question":"Is N1(\\N=C\\c(ccc2Sc3cccc(cccn4)c34)o2)C(C)=Nc(c5C1=O)cccc5 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":32399
  },
  {
    "COADD_ID":"CO-ADD:0323766",
    "INHIB_AVE":12.45,
    "SMILES":"C(NCCC(CC(CC1C2)CC23)(C3)C1)(C(F)(F)F)(C(F)(F)F)NC(=O)c4ccc(cc4)OC",
    "HIT":0.0,
    "question":"Is C(NCCC(CC(CC1C2)CC23)(C3)C1)(C(F)(F)F)(C(F)(F)F)NC(=O)c4ccc(cc4)OC capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":11572
  },
  {
    "COADD_ID":"CO-ADD:0257428",
    "INHIB_AVE":4.59,
    "SMILES":"C12c3c(cccc3)C(CC1C(=O)Nc(cc4)ccc4C(C)=O)c(cccc5)c25",
    "HIT":0.0,
    "question":"Is C12c3c(cccc3)C(CC1C(=O)Nc(cc4)ccc4C(C)=O)c(cccc5)c25 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":37472
  },
  {
    "COADD_ID":"CO-ADD:0329434",
    "INHIB_AVE":0.85,
    "SMILES":"C1(C(NCCc(c2c([nH]3)ccc(c2)OC(F)(F)F)c3C)=O)=Cc(cccc4OC)c4OC1=O",
    "HIT":0.0,
    "question":"Does treatment with C1(C(NCCc(c2c([nH]3)ccc(c2)OC(F)(F)F)c3C)=O)=Cc(cccc4OC)c4OC1=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":54094
  },
  {
    "COADD_ID":"CO-ADD:0244601",
    "INHIB_AVE":-7.88,
    "SMILES":"[N+](=O)([O-])c1c(C)ccc(c1)C(=O)Oc2ccc(cc2Cl)OC(=O)c(ccc(c3[N+](=O)[O-])C)c3",
    "HIT":0.0,
    "question":"Can exposure to [N+](=O)([O-])c1c(C)ccc(c1)C(=O)Oc2ccc(cc2Cl)OC(=O)c(ccc(c3[N+](=O)[O-])C)c3 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":76562
  },
  {
    "COADD_ID":"CO-ADD:0257163",
    "INHIB_AVE":-1.38,
    "SMILES":"n12c(S\\C(=C\\c(c(cccc3)c3n4Cc5ccccc5)c4)\\C1=O)nc(cc(C)c(C)c6)c26",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound n12c(S\\C(=C\\c(c(cccc3)c3n4Cc5ccccc5)c4)\\C1=O)nc(cc(C)c(C)c6)c26?",
    "answer":"No",
    "_id":62327
  },
  {
    "COADD_ID":"CO-ADD:0229745",
    "INHIB_AVE":11.87,
    "SMILES":"c1(c(Br)cc(cc1\\C=N\/NC(COc2cccc(Cl)c2)=O)Br)OC(=O)c(cc3OC)cc(c3OC)OC",
    "HIT":0.0,
    "question":"Is c1(c(Br)cc(cc1\\C=N\/NC(COc2cccc(Cl)c2)=O)Br)OC(=O)c(cc3OC)cc(c3OC)OC capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":12692
  },
  {
    "COADD_ID":"CO-ADD:0232338",
    "INHIB_AVE":5.86,
    "SMILES":"C1(=Cc2c(OC1=O)cccc2)C(=O)Nc(cc3)ccc3c(cc4)ccc4[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Does treatment with C1(=Cc2c(OC1=O)cccc2)C(=O)Nc(cc3)ccc3c(cc4)ccc4[N+](=O)[O-] result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":31843
  },
  {
    "COADD_ID":"CO-ADD:0254490",
    "INHIB_AVE":1.23,
    "SMILES":"S(CCCC)(=O)(=O)C1C(C(CC12)C=C2)\\C=C\\S(CCCC)(=O)=O",
    "HIT":0.0,
    "question":"Does S(CCCC)(=O)(=O)C1C(C(CC12)C=C2)\\C=C\\S(CCCC)(=O)=O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":52437
  },
  {
    "COADD_ID":"CO-ADD:0278842",
    "INHIB_AVE":7.27,
    "SMILES":"C(=N\/c(cccc1C(F)(F)F)c1)(\/SC=C2c3ccc(c(C)c3)C)\\N2CCCO.Br",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C(=N\/c(cccc1C(F)(F)F)c1)(\/SC=C2c3ccc(c(C)c3)C)\\N2CCCO.Br?",
    "answer":"No",
    "_id":25967
  },
  {
    "COADD_ID":"CO-ADD:0331370",
    "INHIB_AVE":-3.45,
    "SMILES":"C(C(O)=O)C(c1ccc(cc1)OC)NC(Cc2ccccc2)=O",
    "HIT":0.0,
    "question":"Is C(C(O)=O)C(c1ccc(cc1)OC)NC(Cc2ccccc2)=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":68401
  },
  {
    "COADD_ID":"CO-ADD:0299582",
    "INHIB_AVE":5.55,
    "SMILES":"c1(C(O)=O)c2c(cccc2)nc(c3ccccc3)c1SCC",
    "HIT":0.0,
    "question":"Does c1(C(O)=O)c2c(cccc2)nc(c3ccccc3)c1SCC show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":33201
  },
  {
    "COADD_ID":"CO-ADD:0247975",
    "INHIB_AVE":-1.43,
    "SMILES":"N1(CCc2ccccc2)C(=O)CC(N(CC3)CCS3)C1=O",
    "HIT":0.0,
    "question":"Can N1(CCc2ccccc2)C(=O)CC(N(CC3)CCS3)C1=O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":62502
  },
  {
    "COADD_ID":"CO-ADD:0158655",
    "INHIB_AVE":2.78,
    "SMILES":"O=C1C2=C(CCC1)OC(C=C3)=C2C=C3OC(C)=O",
    "HIT":0.0,
    "question":"Can exposure to O=C1C2=C(CCC1)OC(C=C3)=C2C=C3OC(C)=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":45643
  },
  {
    "COADD_ID":"CO-ADD:0228164",
    "INHIB_AVE":5.91,
    "SMILES":"C(CNc1cccc(cccc2)c12)(=O)N\\N=C\\c3cccc(Br)c3",
    "HIT":0.0,
    "question":"Does treatment with C(CNc1cccc(cccc2)c12)(=O)N\\N=C\\c3cccc(Br)c3 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":31639
  },
  {
    "COADD_ID":"CO-ADD:0303157",
    "INHIB_AVE":1.18,
    "SMILES":"C(=C\/c(ccc(c1OC)OCCSCC(OCC)=O)c1)(\/C(=O)N(C)C(N2C)=O)\\C2=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C(=C\/c(ccc(c1OC)OCCSCC(OCC)=O)c1)(\/C(=O)N(C)C(N2C)=O)\\C2=O?",
    "answer":"No",
    "_id":52700
  },
  {
    "COADD_ID":"CO-ADD:0305916",
    "INHIB_AVE":-11.97,
    "SMILES":"c1(NC(=O)C(c2ccccc2)c3ccccc3)sc(c4c1C(N)=O)CCCC4",
    "HIT":0.0,
    "question":"Is c1(NC(=O)C(c2ccccc2)c3ccccc3)sc(c4c1C(N)=O)CCCC4 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":80003
  },
  {
    "COADD_ID":"CO-ADD:0222369",
    "INHIB_AVE":-7.03,
    "SMILES":"c1(N(CC2)CCO2)nc(N\\N=C\/c3ccccc3Br)nc(Nc(cc4)ccc4[N+](=O)[O-])n1",
    "HIT":0.0,
    "question":"Does c1(N(CC2)CCO2)nc(N\\N=C\/c3ccccc3Br)nc(Nc(cc4)ccc4[N+](=O)[O-])n1 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":75381
  },
  {
    "COADD_ID":"CO-ADD:0301605",
    "INHIB_AVE":42.08,
    "SMILES":"C(=O)(Nc(cc1)ccc1F)CCN(CC2)CCN2CCO",
    "HIT":0.0,
    "question":"Is C(=O)(Nc(cc1)ccc1F)CCN(CC2)CCN2CCO effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":523
  },
  {
    "COADD_ID":"CO-ADD:0164878",
    "INHIB_AVE":17.12,
    "SMILES":"CC(C)CC(N(C)C)C1(CCC1)c1ccc(Cl)cc1",
    "HIT":0.0,
    "question":"Does CC(C)CC(N(C)C)C1(CCC1)c1ccc(Cl)cc1 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":5164
  },
  {
    "COADD_ID":"CO-ADD:0162847",
    "INHIB_AVE":11.42,
    "SMILES":"c1(\\C=N\\NC(COc(cc2)ccc2Br)=O)cc(OC)ccc1OC",
    "HIT":0.0,
    "question":"Can exposure to c1(\\C=N\\NC(COc(cc2)ccc2Br)=O)cc(OC)ccc1OC lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":13626
  },
  {
    "COADD_ID":"CO-ADD:0140016",
    "INHIB_AVE":-0.93,
    "SMILES":"ClC1=C(C2=CC=CC=C2NC3=CC=CC=C3)C(Cl)=CC(Br)=C1",
    "HIT":0.0,
    "question":"Can exposure to ClC1=C(C2=CC=CC=C2NC3=CC=CC=C3)C(Cl)=CC(Br)=C1 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":60892
  },
  {
    "COADD_ID":"CO-ADD:0154878",
    "INHIB_AVE":2.78,
    "SMILES":"N#CC1=C(N)OC(CC2(C)C)=C(C(C2)=O)C1C3=CC=C(C)S3",
    "HIT":0.0,
    "question":"Does the proposed molecule N#CC1=C(N)OC(CC2(C)C)=C(C(C2)=O)C1C3=CC=C(C)S3 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":45642
  },
  {
    "COADD_ID":"CO-ADD:0305294",
    "INHIB_AVE":-6.51,
    "SMILES":"C(=O)(C(CC)(CC)O)NN1CCCCC1",
    "HIT":0.0,
    "question":"Can exposure to C(=O)(C(CC)(CC)O)NN1CCCCC1 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":74573
  },
  {
    "COADD_ID":"CO-ADD:0232894",
    "INHIB_AVE":8.28,
    "SMILES":"S(c1ccccc1)(=O)(=O)N(CC(=O)Nc2cc(C)ccc2C)c3ccc(cc3Cl)Cl",
    "HIT":0.0,
    "question":"Can exposure to S(c1ccccc1)(=O)(=O)N(CC(=O)Nc2cc(C)ccc2C)c3ccc(cc3Cl)Cl lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":22195
  },
  {
    "COADD_ID":"CO-ADD:0312582",
    "INHIB_AVE":-1.66,
    "SMILES":"C([C@H]1O[C@@]23[C@]([C@@]14[H])([H])[C@@](C5C(OC)=O)(O[C@H]4C5C(OC)=O)COC2)C3",
    "HIT":0.0,
    "question":"Can C([C@H]1O[C@@]23[C@]([C@@]14[H])([H])[C@@](C5C(OC)=O)(O[C@H]4C5C(OC)=O)COC2)C3 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":63278
  },
  {
    "COADD_ID":"CO-ADD:0230730",
    "INHIB_AVE":15.02,
    "SMILES":"C(Oc(cc1)ccc1C(=O)Nc(cc2)ccc2Br)(=S)Nc(cc3)ccc3Br",
    "HIT":0.0,
    "question":"Does C(Oc(cc1)ccc1C(=O)Nc(cc2)ccc2Br)(=S)Nc(cc3)ccc3Br show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":7575
  },
  {
    "COADD_ID":"CO-ADD:0240744",
    "INHIB_AVE":25.07,
    "SMILES":"C(=O)(\\C=C\\CCCCC)Nc(cc1)ccc1NC(=O)\\C=C\\CCCCC",
    "HIT":0.0,
    "question":"Does C(=O)(\\C=C\\CCCCC)Nc(cc1)ccc1NC(=O)\\C=C\\CCCCC demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":1163
  },
  {
    "COADD_ID":"CO-ADD:0221149",
    "INHIB_AVE":6.36,
    "SMILES":"S(c1ccccc1)(=O)(=O)N(CC(=O)NC2CCCCC2O)c3c(OC)ccc(OC)c3",
    "HIT":0.0,
    "question":"Can exposure to S(c1ccccc1)(=O)(=O)N(CC(=O)NC2CCCCC2O)c3c(OC)ccc(OC)c3 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":29730
  },
  {
    "COADD_ID":"CO-ADD:0233511",
    "INHIB_AVE":16.58,
    "SMILES":"C(=C\\c(ccc(c12)OCO1)c2)(\/NC(c3ccccc3)=O)\\C(=O)N\\N=C\\c(cccc4OC(=O)c5ccccc5Br)c4",
    "HIT":0.0,
    "question":"Does C(=C\\c(ccc(c12)OCO1)c2)(\/NC(c3ccccc3)=O)\\C(=O)N\\N=C\\c(cccc4OC(=O)c5ccccc5Br)c4 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":5724
  },
  {
    "COADD_ID":"CO-ADD:0321043",
    "INHIB_AVE":5.48,
    "SMILES":"n1(c(c(C)c2)cc(c2NS(=O)(=O)c3ccc(cc3)NC(C)=O)O)nc4c(cccc4)n1",
    "HIT":0.0,
    "question":"Does the proposed molecule n1(c(c(C)c2)cc(c2NS(=O)(=O)c3ccc(cc3)NC(C)=O)O)nc4c(cccc4)n1 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":33546
  },
  {
    "COADD_ID":"CO-ADD:0329371",
    "INHIB_AVE":9.04,
    "SMILES":"c1(C(O)=O)cc(OC)c(cc1NC(=O)c(cccc2[N+](=O)[O-])c2C)OC",
    "HIT":0.0,
    "question":"Does c1(C(O)=O)cc(OC)c(cc1NC(=O)c(cccc2[N+](=O)[O-])c2C)OC show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":19738
  },
  {
    "COADD_ID":"CO-ADD:0158128",
    "INHIB_AVE":13.77,
    "SMILES":"N#CC(C=CC=C1)=C1OCC(N\/N=C\/C2=CC=C(C=C2)OC(C3=CC=C(C=C3)[N+]([O-])=O)=O)=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound N#CC(C=CC=C1)=C1OCC(N\/N=C\/C2=CC=C(C=C2)OC(C3=CC=C(C=C3)[N+]([O-])=O)=O)=O?",
    "answer":"No",
    "_id":9382
  },
  {
    "COADD_ID":"CO-ADD:0302618",
    "INHIB_AVE":9.1,
    "SMILES":"N1(CC)C(\\C=C\\c(cc2)ccc2Br)=Nc(c3C1=O)cccc3",
    "HIT":0.0,
    "question":"Does N1(CC)C(\\C=C\\c(cc2)ccc2Br)=Nc(c3C1=O)cccc3 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":19583
  },
  {
    "COADD_ID":"CO-ADD:0161748",
    "INHIB_AVE":11.06,
    "SMILES":"c(Nc(cc1)ccc1[N+](=O)[O-])(nc(N\\N=C\\c(cc2)ccc2[N+](=O)[O-])nc3Nc4ccccc4)n3",
    "HIT":0.0,
    "question":"Does c(Nc(cc1)ccc1[N+](=O)[O-])(nc(N\\N=C\\c(cc2)ccc2[N+](=O)[O-])nc3Nc4ccccc4)n3 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":14393
  },
  {
    "COADD_ID":"CO-ADD:0255409",
    "INHIB_AVE":-2.3,
    "SMILES":"n1(Cc2ccc(cc2Cl)Cl)c3c(nc1SCC)cccc3",
    "HIT":0.0,
    "question":"Does n1(Cc2ccc(cc2Cl)Cl)c3c(nc1SCC)cccc3 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":65269
  },
  {
    "COADD_ID":"CO-ADD:0287310",
    "INHIB_AVE":12.96,
    "SMILES":"c1(sc(cn1)Cc2cc(Cl)ccc2Cl)NC(C)=O",
    "HIT":0.0,
    "question":"Can exposure to c1(sc(cn1)Cc2cc(Cl)ccc2Cl)NC(C)=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":10639
  },
  {
    "COADD_ID":"CO-ADD:0287986",
    "INHIB_AVE":-6.1,
    "SMILES":"C(C(=O)OCC1CCCO1)(=C(C)NC(=C23)CCCC2=O)C3c4ccc(c(O)c4)OC",
    "HIT":0.0,
    "question":"Does C(C(=O)OCC1CCCO1)(=C(C)NC(=C23)CCCC2=O)C3c4ccc(c(O)c4)OC show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":73917
  },
  {
    "COADD_ID":"CO-ADD:0225943",
    "INHIB_AVE":13.61,
    "SMILES":"N12C(C=CC(c3ccc(c(C)c3)C)=N1)=NN(CC(=O)NCc(cc4)ccc4Cl)C2=O",
    "HIT":0.0,
    "question":"Is N12C(C=CC(c3ccc(c(C)c3)C)=N1)=NN(CC(=O)NCc(cc4)ccc4Cl)C2=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":9614
  },
  {
    "COADD_ID":"CO-ADD:0292000",
    "INHIB_AVE":9.5,
    "SMILES":"c1(C(F)(F)F)nc(sc1c2ccc(cc2)F)Nc(cc3)ccc3OCC",
    "HIT":0.0,
    "question":"Can exposure to c1(C(F)(F)F)nc(sc1c2ccc(cc2)F)Nc(cc3)ccc3OCC lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":18402
  },
  {
    "COADD_ID":"CO-ADD:0217971",
    "INHIB_AVE":0.38,
    "SMILES":"c1(SCC(=O)Nc(ccc(c23)cccc2)c3)ccc(\\C=N\\NC(COC)=O)o1",
    "HIT":0.0,
    "question":"Does treatment with c1(SCC(=O)Nc(ccc(c23)cccc2)c3)ccc(\\C=N\\NC(COC)=O)o1 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":55963
  },
  {
    "COADD_ID":"CO-ADD:0158219",
    "INHIB_AVE":-13.12,
    "SMILES":"O=C(C(C=C1)=CC=C1NC(C)=O)N\/N=C(C)\/C2CC2",
    "HIT":0.0,
    "question":"Is O=C(C(C=C1)=CC=C1NC(C)=O)N\/N=C(C)\/C2CC2 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":80566
  },
  {
    "COADD_ID":"CO-ADD:0228069",
    "INHIB_AVE":3.54,
    "SMILES":"c1(O)c(cc(cc1C(C)(C)C)\\C=N\\NC(CNc(ccc(c23)cccc2)c3)=O)C(C)(C)C",
    "HIT":0.0,
    "question":"Is c1(O)c(cc(cc1C(C)(C)C)\\C=N\\NC(CNc(ccc(c23)cccc2)c3)=O)C(C)(C)C capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":42200
  },
  {
    "COADD_ID":"CO-ADD:0166164",
    "INHIB_AVE":8.17,
    "SMILES":"C12(C)C(C1C(=O)N\\N=C\\c(cc3)ccc3[N+](=O)[O-])CCCC2",
    "HIT":0.0,
    "question":"Does C12(C)C(C1C(=O)N\\N=C\\c(cc3)ccc3[N+](=O)[O-])CCCC2 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":22593
  },
  {
    "COADD_ID":"CO-ADD:0240935",
    "INHIB_AVE":8.8,
    "SMILES":"C1(C2c(cc3)ccc3C(C)C)=C(CC(C)(C)CC1=O)NC(CC(C)(C)CC4=O)=C24",
    "HIT":0.0,
    "question":"Does C1(C2c(cc3)ccc3C(C)C)=C(CC(C)(C)CC1=O)NC(CC(C)(C)CC4=O)=C24 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":20540
  },
  {
    "COADD_ID":"CO-ADD:0229770",
    "INHIB_AVE":3.86,
    "SMILES":"c1(c2ccco2)c(C#N)c(oc1c3ccoc3)\\N=C\\c4ccccc4O",
    "HIT":0.0,
    "question":"Does c1(c2ccco2)c(C#N)c(oc1c3ccoc3)\\N=C\\c4ccccc4O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":40793
  },
  {
    "COADD_ID":"CO-ADD:0222304",
    "INHIB_AVE":-2.13,
    "SMILES":"c1(c2cccc(cccc3)c23)oc(c4n1)ccc(c4)\\N=C\\c(cc(Cl)cc5Cl)c5O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(c2cccc(cccc3)c23)oc(c4n1)ccc(c4)\\N=C\\c(cc(Cl)cc5Cl)c5O?",
    "answer":"No",
    "_id":64735
  },
  {
    "COADD_ID":"CO-ADD:0257081",
    "INHIB_AVE":-4.08,
    "SMILES":"N1(c2ccc(cc2)OC)C(=O)\\C(\\SC1=S)=C\/c(ccc3c(cccc4C(O)=O)c4)o3",
    "HIT":0.0,
    "question":"Is N1(c2ccc(cc2)OC)C(=O)\\C(\\SC1=S)=C\/c(ccc3c(cccc4C(O)=O)c4)o3 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":69922
  },
  {
    "COADD_ID":"CO-ADD:0217517",
    "INHIB_AVE":2.89,
    "SMILES":"c1(c2ccc(cc2)\\N=C\\c(cc(Br)cc3Cl)c3O)sc4c(ccc(C)c4)n1",
    "HIT":0.0,
    "question":"Can c1(c2ccc(cc2)\\N=C\\c(cc(Br)cc3Cl)c3O)sc4c(ccc(C)c4)n1 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":45180
  },
  {
    "COADD_ID":"CO-ADD:0324424",
    "INHIB_AVE":-0.26,
    "SMILES":"C1(O)(c2c(NC1=O)cccc2)CC(=O)C3CC(CC34)C=C4",
    "HIT":0.0,
    "question":"Can C1(O)(c2c(NC1=O)cccc2)CC(=O)C3CC(CC34)C=C4 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":58446
  },
  {
    "COADD_ID":"CO-ADD:0332369",
    "INHIB_AVE":-12.25,
    "SMILES":"S(=O)(=O)(N(CC1)CCN1c2ccccn2)c3cccc(nsn4)c34",
    "HIT":0.0,
    "question":"Does S(=O)(=O)(N(CC1)CCN1c2ccccn2)c3cccc(nsn4)c34 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":80182
  },
  {
    "COADD_ID":"CO-ADD:0222300",
    "INHIB_AVE":-4.98,
    "SMILES":"n1c(N(C)C)nc(nc1N(CC2)CCO2)N\\N=C\\c3ccc(cc3OC)OC",
    "HIT":0.0,
    "question":"Can exposure to n1c(N(C)C)nc(nc1N(CC2)CCO2)N\\N=C\\c3ccc(cc3OC)OC lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":71844
  },
  {
    "COADD_ID":"CO-ADD:0137838",
    "INHIB_AVE":6.88,
    "SMILES":"NCC(C1)=NOC1CC2=C(OC)C(OCO3)=C3C(OC)=C2.Cl.Cl",
    "HIT":0.0,
    "question":"Is NCC(C1)=NOC1CC2=C(OC)C(OCO3)=C3C(OC)=C2.Cl.Cl capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":27482
  },
  {
    "COADD_ID":"CO-ADD:0290598",
    "INHIB_AVE":13.22,
    "SMILES":"c12c(nnc(SC(CC)C(=O)N(c3c4cccc3)c5c(S4)cccc5)n1)c(c6n2C)cc(cc6)Br",
    "HIT":0.0,
    "question":"Can c12c(nnc(SC(CC)C(=O)N(c3c4cccc3)c5c(S4)cccc5)n1)c(c6n2C)cc(cc6)Br effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":10220
  },
  {
    "COADD_ID":"CO-ADD:0220415",
    "INHIB_AVE":13.69,
    "SMILES":"c1(c2ccccc2)[nH]c3c(ccc(c3)\\N=C\\c(c(O)ccc4[N+](=O)[O-])c4)n1",
    "HIT":0.0,
    "question":"Is c1(c2ccccc2)[nH]c3c(ccc(c3)\\N=C\\c(c(O)ccc4[N+](=O)[O-])c4)n1 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":9496
  },
  {
    "COADD_ID":"CO-ADD:0253516",
    "INHIB_AVE":18.66,
    "SMILES":"C1(C#N)(C#N)[C@H](c2ccc(cc2)OCC)[C@@]([H])(C3)C(C(C#N)=C1N)=CCN3CC",
    "HIT":0.0,
    "question":"Does C1(C#N)(C#N)[C@H](c2ccc(cc2)OCC)[C@@]([H])(C3)C(C(C#N)=C1N)=CCN3CC show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":3781
  },
  {
    "COADD_ID":"CO-ADD:0284781",
    "INHIB_AVE":7.86,
    "SMILES":"c1(\\C=C(\/c2ccc(cc2)F)\\OC(=O)c3ccc(cc3)F)nc(c4n1CC(C)C)cccc4",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(\\C=C(\/c2ccc(cc2)F)\\OC(=O)c3ccc(cc3)F)nc(c4n1CC(C)C)cccc4?",
    "answer":"No",
    "_id":23729
  },
  {
    "COADD_ID":"CO-ADD:0287970",
    "INHIB_AVE":-8.84,
    "SMILES":"C12=C(CC(c3ccc(cc3)Cl)CC1=O)Nc(c4NC2c5cc6c(cc5Br)OCO6)cccc4",
    "HIT":0.0,
    "question":"Does the proposed molecule C12=C(CC(c3ccc(cc3)Cl)CC1=O)Nc(c4NC2c5cc6c(cc5Br)OCO6)cccc4 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":77680
  },
  {
    "COADD_ID":"CO-ADD:0136332",
    "INHIB_AVE":15.71,
    "SMILES":"c1c(S(N=S(\/C)C)(=O)=O)ccc(NC(C)=O)c1",
    "HIT":0.0,
    "question":"Does the proposed molecule c1c(S(N=S(\/C)C)(=O)=O)ccc(NC(C)=O)c1 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":6700
  },
  {
    "COADD_ID":"CO-ADD:0324259",
    "INHIB_AVE":6.7,
    "SMILES":"N1(c2ccc(cc2)F)C(=O)\\C(\\C(CCC)=N1)=C\\NCc3ccco3",
    "HIT":0.0,
    "question":"Can N1(c2ccc(cc2)F)C(=O)\\C(\\C(CCC)=N1)=C\\NCc3ccco3 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":28254
  },
  {
    "COADD_ID":"CO-ADD:0240244",
    "INHIB_AVE":0.12,
    "SMILES":"C(=O)(Nc1ccccc1C)Nc(cc2)c(OC)cc2c(cc3)cc(c3NC(=O)Nc4ccccc4C)OC",
    "HIT":0.0,
    "question":"Is C(=O)(Nc1ccccc1C)Nc(cc2)c(OC)cc2c(cc3)cc(c3NC(=O)Nc4ccccc4C)OC effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":57023
  },
  {
    "COADD_ID":"CO-ADD:0166263",
    "INHIB_AVE":59.56,
    "SMILES":"[N+](=O)([O-])c(cc1)cc(c1C(=O)Nc2cc(C)ccc2OC)Cl",
    "HIT":0.0,
    "question":"Does the proposed molecule [N+](=O)([O-])c(cc1)cc(c1C(=O)Nc2cc(C)ccc2OC)Cl exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":446
  },
  {
    "COADD_ID":"CO-ADD:0233291",
    "INHIB_AVE":5.05,
    "SMILES":"c(C(O)=O)(cc1I)c(cc1[N+](=O)[O-])[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Does treatment with c(C(O)=O)(cc1I)c(cc1[N+](=O)[O-])[N+](=O)[O-] result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":35417
  },
  {
    "COADD_ID":"CO-ADD:0327519",
    "INHIB_AVE":-0.12,
    "SMILES":"c1(\\C(\\CCC2)=N\\OCc(cc3)ccc3F)c2non1",
    "HIT":0.0,
    "question":"Is c1(\\C(\\CCC2)=N\\OCc(cc3)ccc3F)c2non1 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":57952
  },
  {
    "COADD_ID":"CO-ADD:0235559",
    "INHIB_AVE":10.7,
    "SMILES":"n1cn[nH]c1SCC(=O)Nc2ccccc2",
    "HIT":0.0,
    "question":"Does n1cn[nH]c1SCC(=O)Nc2ccccc2 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":15212
  },
  {
    "COADD_ID":"CO-ADD:0160206",
    "INHIB_AVE":6.21,
    "SMILES":"ClC1=CC(C2=CC=C(\/C=N\/C3=CC(C4=NC(C=CC=C5)=C5O4)=CC=C3)O2)=CC=C1Cl",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound ClC1=CC(C2=CC=C(\/C=N\/C3=CC(C4=NC(C=CC=C5)=C5O4)=CC=C3)O2)=CC=C1Cl?",
    "answer":"No",
    "_id":30356
  },
  {
    "COADD_ID":"CO-ADD:0329189",
    "INHIB_AVE":17.37,
    "SMILES":"C1(C(=O)NC(N2CCc(ccc(c3OCC)OCC)c3)=O)=C2NC(=O)C1(NC(CC)=O)C(F)(F)F",
    "HIT":0.0,
    "question":"Does C1(C(=O)NC(N2CCc(ccc(c3OCC)OCC)c3)=O)=C2NC(=O)C1(NC(CC)=O)C(F)(F)F show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":4910
  },
  {
    "COADD_ID":"CO-ADD:0149165",
    "INHIB_AVE":-2.44,
    "SMILES":"c(c1)c([nH]2)c(c(C(=O)C(=O)Nc(c3)cc(OC)c(OC)c3OC)c2)cc1",
    "HIT":0.0,
    "question":"Can c(c1)c([nH]2)c(c(C(=O)C(=O)Nc(c3)cc(OC)c(OC)c3OC)c2)cc1 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":65651
  },
  {
    "COADD_ID":"CO-ADD:0236445",
    "INHIB_AVE":5.08,
    "SMILES":"n1c(SCC(=O)Nc2ccccc2[N+](=O)[O-])[nH]nc1c3ccccc3",
    "HIT":0.0,
    "question":"Does n1c(SCC(=O)Nc2ccccc2[N+](=O)[O-])[nH]nc1c3ccccc3 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":35307
  },
  {
    "COADD_ID":"CO-ADD:0220626",
    "INHIB_AVE":-4.97,
    "SMILES":"C(=O)(C(c1ccccc1)c2ccccc2)NCC(=O)N\\N=C\\c3cc(OC)ccc3O",
    "HIT":0.0,
    "question":"Does treatment with C(=O)(C(c1ccccc1)c2ccccc2)NCC(=O)N\\N=C\\c3cc(OC)ccc3O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":71814
  },
  {
    "COADD_ID":"CO-ADD:0302829",
    "INHIB_AVE":1.15,
    "SMILES":"n1(CCc2ccccc2)c(S)nnc1c(cc3)ccn3",
    "HIT":0.0,
    "question":"Does treatment with n1(CCc2ccccc2)c(S)nnc1c(cc3)ccn3 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":52851
  },
  {
    "COADD_ID":"CO-ADD:0222592",
    "INHIB_AVE":1.7,
    "SMILES":"C1(CC(OC12CCCCC2)=O)C(=O)NNC(N)=S",
    "HIT":0.0,
    "question":"Can C1(CC(OC12CCCCC2)=O)C(=O)NNC(N)=S effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":50457
  },
  {
    "COADD_ID":"CO-ADD:0331938",
    "INHIB_AVE":19.15,
    "SMILES":"[N+](=O)([O-])c(c1)cc(cc1C(=O)N(CC2)CCN2Cc(ccc(c34)OCO3)c4)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Does treatment with [N+](=O)([O-])c(c1)cc(cc1C(=O)N(CC2)CCN2Cc(ccc(c34)OCO3)c4)[N+](=O)[O-] result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":3416
  },
  {
    "COADD_ID":"CO-ADD:0291437",
    "INHIB_AVE":5.54,
    "SMILES":"c1(c2c(sc1NC(=O)c3ccco3)CCCC2)C(=O)Nc(cc4)ccc4Br",
    "HIT":0.0,
    "question":"Does c1(c2c(sc1NC(=O)c3ccco3)CCCC2)C(=O)Nc(cc4)ccc4Br demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":33240
  },
  {
    "COADD_ID":"CO-ADD:0247357",
    "INHIB_AVE":10.37,
    "SMILES":"N1(c2cccc(Br)c2)C(=O)CC(N(CC3)CCC3C(N)=O)C1=O",
    "HIT":0.0,
    "question":"Does the proposed molecule N1(c2cccc(Br)c2)C(=O)CC(N(CC3)CCC3C(N)=O)C1=O exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":16071
  },
  {
    "COADD_ID":"CO-ADD:0148823",
    "INHIB_AVE":6.91,
    "SMILES":"Oc(c(c1c2ccccc2)c3cc(c(cc3O)C#N)C#N)n[nH]1",
    "HIT":0.0,
    "question":"Does treatment with Oc(c(c1c2ccccc2)c3cc(c(cc3O)C#N)C#N)n[nH]1 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":27337
  },
  {
    "COADD_ID":"CO-ADD:0277510",
    "INHIB_AVE":1.93,
    "SMILES":"N1(C)C(=O)\\C(\\SC1=S)=C\/c(ccc(c2OC)OCc3ccccc3F)c2",
    "HIT":0.0,
    "question":"Can N1(C)C(=O)\\C(\\SC1=S)=C\/c(ccc(c2OC)OCc3ccccc3F)c2 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":49414
  },
  {
    "COADD_ID":"CO-ADD:0307448",
    "INHIB_AVE":-3.27,
    "SMILES":"c1(Oc2cccc(c2)NC(CC(C)C)=O)nc(C)cc(C)c1C#N",
    "HIT":0.0,
    "question":"Is c1(Oc2cccc(c2)NC(CC(C)C)=O)nc(C)cc(C)c1C#N capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":67919
  },
  {
    "COADD_ID":"CO-ADD:0287798",
    "INHIB_AVE":1.78,
    "SMILES":"C(C#N)(C1(CCCCC1)C(C#N)C(N2)=O)=C2SCC(=O)C34CC(CC5C3)CC(C5)C4",
    "HIT":0.0,
    "question":"Does C(C#N)(C1(CCCCC1)C(C#N)C(N2)=O)=C2SCC(=O)C34CC(CC5C3)CC(C5)C4 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":50075
  },
  {
    "COADD_ID":"CO-ADD:0285633",
    "INHIB_AVE":2.45,
    "SMILES":"N1(c2ccc(cc2Br)Br)C(=O)CC(N(CC3)CCN3Cc4ccccc4)C1=O",
    "HIT":0.0,
    "question":"Does the proposed molecule N1(c2ccc(cc2Br)Br)C(=O)CC(N(CC3)CCN3Cc4ccccc4)C1=O exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":47088
  },
  {
    "COADD_ID":"CO-ADD:0221552",
    "INHIB_AVE":8.31,
    "SMILES":"N1(c2ccccn2)C(=O)c(c3)c(c(c4)C1=O)c(cc3[N+](=O)[O-])cc4[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Does N1(c2ccccn2)C(=O)c(c3)c(c(c4)C1=O)c(cc3[N+](=O)[O-])cc4[N+](=O)[O-] show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":22072
  },
  {
    "COADD_ID":"CO-ADD:0292956",
    "INHIB_AVE":2.39,
    "SMILES":"C(C(=O)c1ccc(cc1)Cl)(C2c3ccccc3)=C(O)C(N2CCNC(C)=O)=O",
    "HIT":0.0,
    "question":"Can exposure to C(C(=O)c1ccc(cc1)Cl)(C2c3ccccc3)=C(O)C(N2CCNC(C)=O)=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":47338
  },
  {
    "COADD_ID":"CO-ADD:0218266",
    "INHIB_AVE":9.71,
    "SMILES":"C(C=C(C#N)C(N1c2ccc(cc2)OC)=N)([N+](=O)[O-])=N1",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C(C=C(C#N)C(N1c2ccc(cc2)OC)=N)([N+](=O)[O-])=N1?",
    "answer":"No",
    "_id":17832
  },
  {
    "COADD_ID":"CO-ADD:0329731",
    "INHIB_AVE":4.08,
    "SMILES":"C1(O)C(NCCc2ccccc2)OC(C(O)C1O)C",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C1(O)C(NCCc2ccccc2)OC(C(O)C1O)C?",
    "answer":"No",
    "_id":39773
  },
  {
    "COADD_ID":"CO-ADD:0293651",
    "INHIB_AVE":-2.81,
    "SMILES":"c1(Cl)c(Cl)ccc(NN)c1.Cl",
    "HIT":0.0,
    "question":"Does c1(Cl)c(Cl)ccc(NN)c1.Cl show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":66713
  },
  {
    "COADD_ID":"CO-ADD:0291994",
    "INHIB_AVE":13.95,
    "SMILES":"N1(C(=O)Cc(cc2)ccc2C)N=C(CC1(O)c3ccc(cc3)Br)CC",
    "HIT":0.0,
    "question":"Does the proposed molecule N1(C(=O)Cc(cc2)ccc2C)N=C(CC1(O)c3ccc(cc3)Br)CC exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":9100
  },
  {
    "COADD_ID":"CO-ADD:0163615",
    "INHIB_AVE":-13.63,
    "SMILES":"c1(OCC(=O)N\\N=C\\c2cc(Br)ccc2OCC(O)=O)c(Br)cc(cc1Br)C",
    "HIT":0.0,
    "question":"Does treatment with c1(OCC(=O)N\\N=C\\c2cc(Br)ccc2OCC(O)=O)c(Br)cc(cc1Br)C result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":80818
  },
  {
    "COADD_ID":"CO-ADD:0332233",
    "INHIB_AVE":9.03,
    "SMILES":"C1(C(OCCOCCC)=O)=C(C)NC(NC1c2cccc(Br)c2)=O",
    "HIT":0.0,
    "question":"Is C1(C(OCCOCCC)=O)=C(C)NC(NC1c2cccc(Br)c2)=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":19809
  },
  {
    "COADD_ID":"CO-ADD:0223061",
    "INHIB_AVE":7.52,
    "SMILES":"S(c1ccccc1)(=O)(=O)N(CC(=O)NC2CCCCC2)c3cc(C)ccc3C",
    "HIT":0.0,
    "question":"Can exposure to S(c1ccccc1)(=O)(=O)N(CC(=O)NC2CCCCC2)c3cc(C)ccc3C lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":25011
  },
  {
    "COADD_ID":"CO-ADD:0225743",
    "INHIB_AVE":8.35,
    "SMILES":"C1(=N2)N(C=CN=C1Sc3ccccc3)C(N2CC(=O)Nc4ccc(cc4Br)C)=O",
    "HIT":0.0,
    "question":"Does treatment with C1(=N2)N(C=CN=C1Sc3ccccc3)C(N2CC(=O)Nc4ccc(cc4Br)C)=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":21955
  },
  {
    "COADD_ID":"CO-ADD:0160377",
    "INHIB_AVE":2.18,
    "SMILES":"[O-][N+](C(C=C1)=CC=C1NC2=NC(N\/N=C\/C3=CC=C(C=C3)\/C=N\/NC4=NC(N5CCCC5)=NC(NC6=CC=C(C=C6)[N+]([O-])=O)=N4)=NC(N7CCCC7)=N2)=O",
    "HIT":0.0,
    "question":"Can [O-][N+](C(C=C1)=CC=C1NC2=NC(N\/N=C\/C3=CC=C(C=C3)\/C=N\/NC4=NC(N5CCCC5)=NC(NC6=CC=C(C=C6)[N+]([O-])=O)=N4)=NC(N7CCCC7)=N2)=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":48284
  },
  {
    "COADD_ID":"CO-ADD:0295316",
    "INHIB_AVE":-18.74,
    "SMILES":"N1(c2c(C)cc(cc2C)C)C(=O)\\C(=C\\Nc3cccc(C)c3)\\C(NC1=O)=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound N1(c2c(C)cc(cc2C)C)C(=O)\\C(=C\\Nc3cccc(C)c3)\\C(NC1=O)=O?",
    "answer":"No",
    "_id":82015
  },
  {
    "COADD_ID":"CO-ADD:0243806",
    "INHIB_AVE":18.34,
    "SMILES":"c1c(c(cc2)ccc2OC)n(c(cc(OC)c3c4OCO3)c4OC)nn1",
    "HIT":0.0,
    "question":"Can c1c(c(cc2)ccc2OC)n(c(cc(OC)c3c4OCO3)c4OC)nn1 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":4025
  },
  {
    "COADD_ID":"CO-ADD:0161379",
    "INHIB_AVE":8.06,
    "SMILES":"N1(c2ccccc2)C(C(C)(C)O)CC(c3ccccc3)=N1",
    "HIT":0.0,
    "question":"Can exposure to N1(c2ccccc2)C(C(C)(C)O)CC(c3ccccc3)=N1 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":22997
  },
  {
    "COADD_ID":"CO-ADD:0218762",
    "INHIB_AVE":7.4,
    "SMILES":"[N+](=O)([O-])c(cccc1C(=O)N\\N=C(\/C)\\CC(=O)Nc2ccccc2CC)c1",
    "HIT":0.0,
    "question":"Does treatment with [N+](=O)([O-])c(cccc1C(=O)N\\N=C(\/C)\\CC(=O)Nc2ccccc2CC)c1 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":25454
  },
  {
    "COADD_ID":"CO-ADD:0293023",
    "INHIB_AVE":1.81,
    "SMILES":"c(c(F)c1F)(c(F)c(c1N2CC(C)CC(C)C2)F)C3Nc(ccc(c45)cccc4)c5C(CC(C)(C)CC6=O)=C36",
    "HIT":0.0,
    "question":"Does treatment with c(c(F)c1F)(c(F)c(c1N2CC(C)CC(C)C2)F)C3Nc(ccc(c45)cccc4)c5C(CC(C)(C)CC6=O)=C36 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":49957
  },
  {
    "COADD_ID":"CO-ADD:0235968",
    "INHIB_AVE":15.12,
    "SMILES":"N1(c2ccccc2C(O)=O)C(=O)c3c(cc(c(Cl)c3)Cl)C1=O",
    "HIT":0.0,
    "question":"Can exposure to N1(c2ccccc2C(O)=O)C(=O)c3c(cc(c(Cl)c3)Cl)C1=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":7446
  },
  {
    "COADD_ID":"CO-ADD:0260169",
    "INHIB_AVE":16.47,
    "SMILES":"C(=O)(Nc(cc1)ccc1OCC)C(=O)NCC(C)O",
    "HIT":0.0,
    "question":"Does treatment with C(=O)(Nc(cc1)ccc1OCC)C(=O)NCC(C)O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":5842
  },
  {
    "COADD_ID":"CO-ADD:0328164",
    "INHIB_AVE":6.68,
    "SMILES":"N1(C(=O)Cn2nnc(c3ccc(cc3)C)n2)c4c(C(CN(C)CC5)C15)cc(C)cc4",
    "HIT":0.0,
    "question":"Is N1(C(=O)Cn2nnc(c3ccc(cc3)C)n2)c4c(C(CN(C)CC5)C15)cc(C)cc4 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":28391
  },
  {
    "COADD_ID":"CO-ADD:0227966",
    "INHIB_AVE":5.0,
    "SMILES":"[N+](=O)([O-])c1ccc(cc1)\\C=N\\NC(CNc2cccc(cccc3)c23)=O",
    "HIT":0.0,
    "question":"Does [N+](=O)([O-])c1ccc(cc1)\\C=N\\NC(CNc2cccc(cccc3)c23)=O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":35646
  },
  {
    "COADD_ID":"CO-ADD:0231135",
    "INHIB_AVE":3.07,
    "SMILES":"N1(CN(CC2)CCO2)C(=O)\\C(\\SC1=O)=C\\c(ccc(c34)OCO3)c4",
    "HIT":0.0,
    "question":"Does the proposed molecule N1(CN(CC2)CCO2)C(=O)\\C(\\SC1=O)=C\\c(ccc(c34)OCO3)c4 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":44350
  },
  {
    "COADD_ID":"CO-ADD:0305973",
    "INHIB_AVE":-0.04,
    "SMILES":"c1(C#N)c(SCC(=O)Nc(c2)cc(cc2C(F)(F)F)C(F)(F)F)nc(cc1C(F)(F)F)c3cccs3",
    "HIT":0.0,
    "question":"Is c1(C#N)c(SCC(=O)Nc(c2)cc(cc2C(F)(F)F)C(F)(F)F)nc(cc1C(F)(F)F)c3cccs3 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":57659
  },
  {
    "COADD_ID":"CO-ADD:0295025",
    "INHIB_AVE":-6.13,
    "SMILES":"c(C(=O)Nc1ccccc1C#N)(c2N)sc3c2cc(c4n3)CCC4",
    "HIT":0.0,
    "question":"Is c(C(=O)Nc1ccccc1C#N)(c2N)sc3c2cc(c4n3)CCC4 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":73980
  },
  {
    "COADD_ID":"CO-ADD:0299238",
    "INHIB_AVE":-4.47,
    "SMILES":"N1(c2ccc(cc2)OCCC)C(=O)CC(N(CC3)CCC3(C(N)=O)N4CCCCC4)C1=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound N1(c2ccc(cc2)OCCC)C(=O)CC(N(CC3)CCC3(C(N)=O)N4CCCCC4)C1=O?",
    "answer":"No",
    "_id":70790
  },
  {
    "COADD_ID":"CO-ADD:0304639",
    "INHIB_AVE":12.85,
    "SMILES":"c1(N(c2ccccc2)c3ccccc3)nc(OC)nc(OC)n1",
    "HIT":0.0,
    "question":"Can c1(N(c2ccccc2)c3ccccc3)nc(OC)nc(OC)n1 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":10848
  },
  {
    "COADD_ID":"CO-ADD:0229263",
    "INHIB_AVE":8.38,
    "SMILES":"C(C)(C)(c1ccc(cc1)Oc(cc2)ccc2NC(C)=O)c3ccc(cc3)Oc(cc4)ccc4NC(C)=O",
    "HIT":0.0,
    "question":"Can exposure to C(C)(C)(c1ccc(cc1)Oc(cc2)ccc2NC(C)=O)c3ccc(cc3)Oc(cc4)ccc4NC(C)=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":21858
  },
  {
    "COADD_ID":"CO-ADD:0154307",
    "INHIB_AVE":4.14,
    "SMILES":"NC1=C2C(CCCC2)=NC3=C1C(C4=CC(Cl)=C(Cl)C=C4)C5=C(O3)C6=C(C=CC=C6)C=C5",
    "HIT":0.0,
    "question":"Does NC1=C2C(CCCC2)=NC3=C1C(C4=CC(Cl)=C(Cl)C=C4)C5=C(O3)C6=C(C=CC=C6)C=C5 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":39541
  },
  {
    "COADD_ID":"CO-ADD:0329605",
    "INHIB_AVE":10.18,
    "SMILES":"S(NCCc(c1c([nH]2)ccc(C)c1)c2C)(=O)(=O)c3c(C)ccc(c3)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Can S(NCCc(c1c([nH]2)ccc(C)c1)c2C)(=O)(=O)c3c(C)ccc(c3)[N+](=O)[O-] act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":16531
  },
  {
    "COADD_ID":"CO-ADD:0157796",
    "INHIB_AVE":-5.11,
    "SMILES":"[O-][N+](C1=C(O)C(\/C=N\/C2=CC3=C(C=C2)OC(C(C=C4)=CC=C4OC)=N3)=CC(C)=C1)=O",
    "HIT":0.0,
    "question":"Does [O-][N+](C1=C(O)C(\/C=N\/C2=CC3=C(C=C2)OC(C(C=C4)=CC=C4OC)=N3)=CC(C)=C1)=O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":72091
  },
  {
    "COADD_ID":"CO-ADD:0328697",
    "INHIB_AVE":12.47,
    "SMILES":"c(c(C)[nH]c1C(OCC)=O)(c2csc(NC(=O)C3CC3)n2)c1C",
    "HIT":0.0,
    "question":"Does c(c(C)[nH]c1C(OCC)=O)(c2csc(NC(=O)C3CC3)n2)c1C demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":11537
  },
  {
    "COADD_ID":"CO-ADD:0245740",
    "INHIB_AVE":10.84,
    "SMILES":"n(nnc1C(=O)N\\N=C\\c(cc2)ccc2Cl)(c1COC)c3nonc3N",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound n(nnc1C(=O)N\\N=C\\c(cc2)ccc2Cl)(c1COC)c3nonc3N?",
    "answer":"No",
    "_id":14894
  },
  {
    "COADD_ID":"CO-ADD:0158301",
    "INHIB_AVE":11.36,
    "SMILES":"O=C(C1N2CCN(CC2)C3=NC=CC=N3)N(C4=CC(Cl)=CC=C4)C(C1)=O",
    "HIT":0.0,
    "question":"Does treatment with O=C(C1N2CCN(CC2)C3=NC=CC=N3)N(C4=CC(Cl)=CC=C4)C(C1)=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":13772
  },
  {
    "COADD_ID":"CO-ADD:0306133",
    "INHIB_AVE":23.87,
    "SMILES":"c1(S(=O)Cc2ccccc2)c(N)c(c3s1)c(C)cc(C)n3",
    "HIT":0.0,
    "question":"Can c1(S(=O)Cc2ccccc2)c(N)c(c3s1)c(C)cc(C)n3 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":1390
  },
  {
    "COADD_ID":"CO-ADD:0287443",
    "INHIB_AVE":-2.9,
    "SMILES":"n(c(c1ccccc1)c2)c3c(c2C(NCCOc4ccccc4)=O)cccc3Cl",
    "HIT":0.0,
    "question":"Does treatment with n(c(c1ccccc1)c2)c3c(c2C(NCCOc4ccccc4)=O)cccc3Cl result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":66968
  },
  {
    "COADD_ID":"CO-ADD:0279078",
    "INHIB_AVE":19.65,
    "SMILES":"C1(C2c3cccs3)=C(c4c(cccc4)OC1=O)OC(N)=C2C#N",
    "HIT":0.0,
    "question":"Can C1(C2c3cccs3)=C(c4c(cccc4)OC1=O)OC(N)=C2C#N effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":3079
  },
  {
    "COADD_ID":"CO-ADD:0327457",
    "INHIB_AVE":7.13,
    "SMILES":"n1(CC=C)c(SCC(=O)Nc2cccc(OC)c2)nnc1c3cccs3",
    "HIT":0.0,
    "question":"Can exposure to n1(CC=C)c(SCC(=O)Nc2cccc(OC)c2)nnc1c3cccs3 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":26505
  },
  {
    "COADD_ID":"CO-ADD:0215059",
    "INHIB_AVE":6.27,
    "SMILES":"N1(c2cccc(I)c2)C(=O)c(c3C1=O)ccc(C(=O)c(cc4)ccc4[N+](=O)[O-])c3",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound N1(c2cccc(I)c2)C(=O)c(c3C1=O)ccc(C(=O)c(cc4)ccc4[N+](=O)[O-])c3?",
    "answer":"No",
    "_id":30123
  },
  {
    "COADD_ID":"CO-ADD:0255877",
    "INHIB_AVE":-30.83,
    "SMILES":"c1(c2ccccc2Cl)noc(C)c1C(NCCOc(cc3)ccc3Cl)=O",
    "HIT":0.0,
    "question":"Does c1(c2ccccc2Cl)noc(C)c1C(NCCOc(cc3)ccc3Cl)=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":82607
  },
  {
    "COADD_ID":"CO-ADD:0331853",
    "INHIB_AVE":-0.35,
    "SMILES":"C1(=O)Nc(c2N1)ccc(c2)\\N=C\\c(ccc3c4CC(O3)C)c4",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C1(=O)Nc(c2N1)ccc(c2)\\N=C\\c(ccc3c4CC(O3)C)c4?",
    "answer":"No",
    "_id":58793
  },
  {
    "COADD_ID":"CO-ADD:0226499",
    "INHIB_AVE":5.07,
    "SMILES":"c12n(C=CN(c3ccc(cc3)Br)C1=O)c(nn2)SCC(=O)c4c5c([nH]c4C)cccc5",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c12n(C=CN(c3ccc(cc3)Br)C1=O)c(nn2)SCC(=O)c4c5c([nH]c4C)cccc5?",
    "answer":"No",
    "_id":35337
  },
  {
    "COADD_ID":"CO-ADD:0302748",
    "INHIB_AVE":54.18,
    "SMILES":"c1(nnc(C(F)(F)F)n1N)n2c(C)cc(C)n2.Cl",
    "HIT":1.0,
    "question":"Can c1(nnc(C(F)(F)F)n1N)n2c(C)cc(C)n2.Cl act as an antibacterial agent targeting Escherichia coli?",
    "answer":"Yes",
    "_id":67
  },
  {
    "COADD_ID":"CO-ADD:0257893",
    "INHIB_AVE":14.47,
    "SMILES":"C(=C\\c(cc(OC)c(c1)OC)c1OC)(\/C(=O)N(C)C(N2C)=O)\\C2=O",
    "HIT":0.0,
    "question":"Can C(=C\\c(cc(OC)c(c1)OC)c1OC)(\/C(=O)N(C)C(N2C)=O)\\C2=O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":8300
  },
  {
    "COADD_ID":"CO-ADD:0260140",
    "INHIB_AVE":-4.48,
    "SMILES":"C(F)(F)(F)c(ccc(c1NC(C)=O)OCc2ccccc2)c1",
    "HIT":0.0,
    "question":"Is C(F)(F)(F)c(ccc(c1NC(C)=O)OCc2ccccc2)c1 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":70803
  },
  {
    "COADD_ID":"CO-ADD:0166399",
    "INHIB_AVE":-0.65,
    "SMILES":"c1(ccc(cc1OC)OC)C(=O)N\\N=C(\/C)\\CC(=O)N(C)c2ccccc2",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(ccc(cc1OC)OC)C(=O)N\\N=C(\/C)\\CC(=O)N(C)c2ccccc2?",
    "answer":"No",
    "_id":59921
  },
  {
    "COADD_ID":"CO-ADD:0256819",
    "INHIB_AVE":-9.47,
    "SMILES":"c12c(ccc(OC)c1C)C(C)=C(C(=O)O2)CC",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c12c(ccc(OC)c1C)C(C)=C(C(=O)O2)CC?",
    "answer":"No",
    "_id":78293
  },
  {
    "COADD_ID":"CO-ADD:0256565",
    "INHIB_AVE":18.9,
    "SMILES":"c(c(C)c(s1)C)(C(=O)N(C)C(=N2)SCc3ccccc3)c12",
    "HIT":0.0,
    "question":"Does treatment with c(c(C)c(s1)C)(C(=O)N(C)C(=N2)SCc3ccccc3)c12 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":3583
  },
  {
    "COADD_ID":"CO-ADD:0278557",
    "INHIB_AVE":7.36,
    "SMILES":"c1(NC(CSC2=NC(C)=CC(=O)N2)=O)sc(c(ccc3C(OC)=O)n1)c3",
    "HIT":0.0,
    "question":"Is c1(NC(CSC2=NC(C)=CC(=O)N2)=O)sc(c(ccc3C(OC)=O)n1)c3 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":25625
  },
  {
    "COADD_ID":"CO-ADD:0225996",
    "INHIB_AVE":1.58,
    "SMILES":"n12c(ccc(c3ccc(cc3)Cl)n1)nnc2CCC(=O)NCc4ccc(cc4Cl)F",
    "HIT":0.0,
    "question":"Does treatment with n12c(ccc(c3ccc(cc3)Cl)n1)nnc2CCC(=O)NCc4ccc(cc4Cl)F result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":50929
  },
  {
    "COADD_ID":"CO-ADD:0245597",
    "INHIB_AVE":23.92,
    "SMILES":"c1(SC(C)C(=O)Nc2c(C)cc(cc2C)C)sc3c(ccc(c3)NC(=O)c4ccc(cc4)OCCCC)n1",
    "HIT":0.0,
    "question":"Can c1(SC(C)C(=O)Nc2c(C)cc(cc2C)C)sc3c(ccc(c3)NC(=O)c4ccc(cc4)OCCCC)n1 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":1374
  },
  {
    "COADD_ID":"CO-ADD:0289033",
    "INHIB_AVE":3.49,
    "SMILES":"C(=O)(N1CCC(CC1)CC(O)=O)c2ccccc2Cl",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C(=O)(N1CCC(CC1)CC(O)=O)c2ccccc2Cl?",
    "answer":"No",
    "_id":42433
  },
  {
    "COADD_ID":"CO-ADD:0332176",
    "INHIB_AVE":9.02,
    "SMILES":"C(C(=O)c1ccc(cc1)OC)(C2c(cccn3)c3)=C(O)C(N2c4ccc(c(Br)c4)C)=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C(C(=O)c1ccc(cc1)OC)(C2c(cccn3)c3)=C(O)C(N2c4ccc(c(Br)c4)C)=O?",
    "answer":"No",
    "_id":19840
  },
  {
    "COADD_ID":"CO-ADD:0162004",
    "INHIB_AVE":0.25,
    "SMILES":"S(=O)(=O)(c1ccc(cc1)NC(c2ccccc2)=O)Nc3nccnc3OC",
    "HIT":0.0,
    "question":"Is S(=O)(=O)(c1ccc(cc1)NC(c2ccccc2)=O)Nc3nccnc3OC effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":56486
  },
  {
    "COADD_ID":"CO-ADD:0232031",
    "INHIB_AVE":-1.04,
    "SMILES":"c1(oc(c2n1)cccc2C)c3cc(ccc3O)\\N=C\\c(cc(Cl)cc4[N+](=O)[O-])c4O",
    "HIT":0.0,
    "question":"Can exposure to c1(oc(c2n1)cccc2C)c3cc(ccc3O)\\N=C\\c(cc(Cl)cc4[N+](=O)[O-])c4O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":61251
  },
  {
    "COADD_ID":"CO-ADD:0287978",
    "INHIB_AVE":-8.54,
    "SMILES":"C12=C(CC(c3ccccc3)CC1=O)Nc(c4NC2c5ccccc5Cl)cccc4",
    "HIT":0.0,
    "question":"Does the proposed molecule C12=C(CC(c3ccccc3)CC1=O)Nc(c4NC2c5ccccc5Cl)cccc4 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":77341
  },
  {
    "COADD_ID":"CO-ADD:0217285",
    "INHIB_AVE":8.19,
    "SMILES":"N1(CNc(cc2)ccc2I)C(=O)\\C(\\SC1=O)=C\\c3ccc(C)o3",
    "HIT":0.0,
    "question":"Does the proposed molecule N1(CNc(cc2)ccc2I)C(=O)\\C(\\SC1=O)=C\\c3ccc(C)o3 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":22495
  },
  {
    "COADD_ID":"CO-ADD:0284265",
    "INHIB_AVE":1.92,
    "SMILES":"c12c(c(ccc1N(CC3)CCO3)C4=O)c(ccc2N(CC5)CCO5)C(O4)=O",
    "HIT":0.0,
    "question":"Is c12c(c(ccc1N(CC3)CCO3)C4=O)c(ccc2N(CC5)CCO5)C(O4)=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":49498
  },
  {
    "COADD_ID":"CO-ADD:0249356",
    "INHIB_AVE":-15.61,
    "SMILES":"S(=O)(=O)(c1ccc(cc1)OCCCC)NCc2ccco2",
    "HIT":0.0,
    "question":"Is S(=O)(=O)(c1ccc(cc1)OCCCC)NCc2ccco2 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":81469
  },
  {
    "COADD_ID":"CO-ADD:0242544",
    "INHIB_AVE":-1.0,
    "SMILES":"N1(c2ccccc2Cl)C(=O)C(C(C1=O)C34C)C(c(c35)cccc5)c(c46)cccc6",
    "HIT":0.0,
    "question":"Can exposure to N1(c2ccccc2Cl)C(=O)C(C(C1=O)C34C)C(c(c35)cccc5)c(c46)cccc6 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":61117
  },
  {
    "COADD_ID":"CO-ADD:0160314",
    "INHIB_AVE":-13.84,
    "SMILES":"O=C(OCC)\/C(Cl)=N\/NC1=CC=CC(Cl)=C1",
    "HIT":0.0,
    "question":"Does treatment with O=C(OCC)\/C(Cl)=N\/NC1=CC=CC(Cl)=C1 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":80907
  },
  {
    "COADD_ID":"CO-ADD:0236504",
    "INHIB_AVE":-4.81,
    "SMILES":"N(CCN1Cc2ccccc2)(Cc3ccccc3)C1c4c(C)cc(cc4C)C",
    "HIT":0.0,
    "question":"Is N(CCN1Cc2ccccc2)(Cc3ccccc3)C1c4c(C)cc(cc4C)C capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":71455
  },
  {
    "COADD_ID":"CO-ADD:0289258",
    "INHIB_AVE":-4.52,
    "SMILES":"n1(CC2CC2)cnnc1C3CCCCN3.Cl.Cl",
    "HIT":0.0,
    "question":"Is n1(CC2CC2)cnnc1C3CCCCN3.Cl.Cl effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":70884
  },
  {
    "COADD_ID":"CO-ADD:0148961",
    "INHIB_AVE":6.9,
    "SMILES":"N1(CCc(c2c([nH]3)ccc(OC)c2)c3C)C(=O)C(C4C1=O)CCCC4",
    "HIT":0.0,
    "question":"Can N1(CCc(c2c([nH]3)ccc(OC)c2)c3C)C(=O)C(C4C1=O)CCCC4 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":27378
  },
  {
    "COADD_ID":"CO-ADD:0162247",
    "INHIB_AVE":2.87,
    "SMILES":"c(Nc1ccccc1)(nc(N\\N=C\\c2cc(Br)ccc2OC)nc3Nc(cc4)ccc4[N+](=O)[O-])n3",
    "HIT":0.0,
    "question":"Is c(Nc1ccccc1)(nc(N\\N=C\\c2cc(Br)ccc2OC)nc3Nc(cc4)ccc4[N+](=O)[O-])n3 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":45257
  },
  {
    "COADD_ID":"CO-ADD:0290726",
    "INHIB_AVE":6.02,
    "SMILES":"n1(c2c(nn1)cc(Cl)cc2)S(=O)(=O)c3ccc(c(C)c3)Cl",
    "HIT":0.0,
    "question":"Is n1(c2c(nn1)cc(Cl)cc2)S(=O)(=O)c3ccc(c(C)c3)Cl effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":31156
  },
  {
    "COADD_ID":"CO-ADD:0278925",
    "INHIB_AVE":4.59,
    "SMILES":"c12c(nc(C)nc1Nc(cc3)ccc3C)c4c(cccc4)o2",
    "HIT":0.0,
    "question":"Does c12c(nc(C)nc1Nc(cc3)ccc3C)c4c(cccc4)o2 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":37484
  },
  {
    "COADD_ID":"CO-ADD:0312604",
    "INHIB_AVE":-3.33,
    "SMILES":"C1=C[C@]2(O[C@H]13)[C@]([C@]4(CN(C(c5ccccc5)=O)C2)O[C@H]6C(=C4C(F)(F)F)C(F)(F)F)([C@@]36[H])[H]",
    "HIT":0.0,
    "question":"Can C1=C[C@]2(O[C@H]13)[C@]([C@]4(CN(C(c5ccccc5)=O)C2)O[C@H]6C(=C4C(F)(F)F)C(F)(F)F)([C@@]36[H])[H] effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":68076
  },
  {
    "COADD_ID":"CO-ADD:0166698",
    "INHIB_AVE":7.43,
    "SMILES":"n1c(ccc(C#N)c1SC\\C=C\\c2ccccc2)c3ccccn3",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound n1c(ccc(C#N)c1SC\\C=C\\c2ccccc2)c3ccccn3?",
    "answer":"No",
    "_id":25362
  },
  {
    "COADD_ID":"CO-ADD:0287490",
    "INHIB_AVE":5.94,
    "SMILES":"c1(c2c(sc1NC(=O)c3ccc(cc3)C)CCCCC2)C(=O)N4CCCCCC4",
    "HIT":0.0,
    "question":"Is c1(c2c(sc1NC(=O)c3ccc(cc3)C)CCCCC2)C(=O)N4CCCCCC4 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":31494
  },
  {
    "COADD_ID":"CO-ADD:0293972",
    "INHIB_AVE":5.5,
    "SMILES":"C1(C(OCC)=O)(CS(C)(=O)=O)OC(C(O)=C1S(C)(=O)=O)=O",
    "HIT":0.0,
    "question":"Does C1(C(OCC)=O)(CS(C)(=O)=O)OC(C(O)=C1S(C)(=O)=O)=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":33448
  },
  {
    "COADD_ID":"CO-ADD:0157020",
    "INHIB_AVE":-5.13,
    "SMILES":"N#CC1=C(SCC(NC(C=CC=C2)=C2I)=O)N=C(C(C=C3)=CC=C3Br)C=C1C4=CC=CC=C4",
    "HIT":0.0,
    "question":"Is N#CC1=C(SCC(NC(C=CC=C2)=C2I)=O)N=C(C(C=C3)=CC=C3Br)C=C1C4=CC=CC=C4 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":72129
  },
  {
    "COADD_ID":"CO-ADD:0231044",
    "INHIB_AVE":6.51,
    "SMILES":"N(C(=O)\\C=C\\c(cccc1Oc2ccccc2)c1)c3cccc(cccc4)c34",
    "HIT":0.0,
    "question":"Is N(C(=O)\\C=C\\c(cccc1Oc2ccccc2)c1)c3cccc(cccc4)c34 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":29064
  },
  {
    "COADD_ID":"CO-ADD:0303993",
    "INHIB_AVE":6.78,
    "SMILES":"N1(CC(CC1=O)C(O)=O)c2cccc(C)c2C",
    "HIT":0.0,
    "question":"Can N1(CC(CC1=O)C(O)=O)c2cccc(C)c2C act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":27903
  },
  {
    "COADD_ID":"CO-ADD:0163093",
    "INHIB_AVE":6.19,
    "SMILES":"n1c(N(CC2)CCO2)c(Nc3ccccc3C)nc(non4)c14",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound n1c(N(CC2)CCO2)c(Nc3ccccc3C)nc(non4)c14?",
    "answer":"No",
    "_id":30465
  },
  {
    "COADD_ID":"CO-ADD:0293682",
    "INHIB_AVE":0.51,
    "SMILES":"c1(cnccn1)C(=O)OCC(=O)c(cc2)ccc2c3ccccc3",
    "HIT":0.0,
    "question":"Does treatment with c1(cnccn1)C(=O)OCC(=O)c(cc2)ccc2c3ccccc3 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":55449
  },
  {
    "COADD_ID":"CO-ADD:0288775",
    "INHIB_AVE":-2.81,
    "SMILES":"C(CC1)(CC2N)(OCC2)CCN1C(c3oc([N+](=O)[O-])cc3)=O.Cl",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C(CC1)(CC2N)(OCC2)CCN1C(c3oc([N+](=O)[O-])cc3)=O.Cl?",
    "answer":"No",
    "_id":66700
  },
  {
    "COADD_ID":"CO-ADD:0291484",
    "INHIB_AVE":4.55,
    "SMILES":"n1(nc(c2C(=O)Nc(cccc3C(F)(F)F)c3)C)c2nc(c4ccc(cc4)Cl)cc1C(F)(F)F",
    "HIT":0.0,
    "question":"Is n1(nc(c2C(=O)Nc(cccc3C(F)(F)F)c3)C)c2nc(c4ccc(cc4)Cl)cc1C(F)(F)F capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":37664
  },
  {
    "COADD_ID":"CO-ADD:0255129",
    "INHIB_AVE":-4.04,
    "SMILES":"S(=O)(=O)(N(c1ccccc1)CC(=O)N\\N=C(\/C)\\c2cccs2)c3ccccc3[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Can S(=O)(=O)(N(c1ccccc1)CC(=O)N\\N=C(\/C)\\c2cccs2)c3ccccc3[N+](=O)[O-] effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":69846
  },
  {
    "COADD_ID":"CO-ADD:0312312",
    "INHIB_AVE":23.13,
    "SMILES":"C(=O)(c(cccc1C(=O)NCc2cccc(cccc3)c23)c1)NCc4cccc(cccc5)c45",
    "HIT":0.0,
    "question":"Is C(=O)(c(cccc1C(=O)NCc2cccc(cccc3)c23)c1)NCc4cccc(cccc5)c45 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":1572
  },
  {
    "COADD_ID":"CO-ADD:0285118",
    "INHIB_AVE":14.31,
    "SMILES":"N(C(c1ccccc1)=O)C(c2cccc(Br)c2)NC(c3ccccc3)=O",
    "HIT":0.0,
    "question":"Does the proposed molecule N(C(c1ccccc1)=O)C(c2cccc(Br)c2)NC(c3ccccc3)=O exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":8548
  },
  {
    "COADD_ID":"CO-ADD:0288843",
    "INHIB_AVE":0.72,
    "SMILES":"C(N(C(=O)OC(C)(C)C)CC1)C(C1)CC(=O)NCC#C",
    "HIT":0.0,
    "question":"Can exposure to C(N(C(=O)OC(C)(C)C)CC1)C(C1)CC(=O)NCC#C lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":54625
  },
  {
    "COADD_ID":"CO-ADD:0221725",
    "INHIB_AVE":1.66,
    "SMILES":"c12c(ccc(O)c1C)\\C(\\CCC2)=N\\NC(=O)c3cccc(F)c3",
    "HIT":0.0,
    "question":"Can exposure to c12c(ccc(O)c1C)\\C(\\CCC2)=N\\NC(=O)c3cccc(F)c3 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":50596
  },
  {
    "COADD_ID":"CO-ADD:0287254",
    "INHIB_AVE":3.49,
    "SMILES":"C(C(OCC)=O)(Nc1ccccn1)(C(F)(F)F)NC(OCC)=O",
    "HIT":0.0,
    "question":"Can exposure to C(C(OCC)=O)(Nc1ccccn1)(C(F)(F)F)NC(OCC)=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":42415
  },
  {
    "COADD_ID":"CO-ADD:0232361",
    "INHIB_AVE":-0.8,
    "SMILES":"C1(C(=O)Nc(cccc2[N+](=O)[O-])c2)=Cc(cccc3CC=C)c3OC1=O",
    "HIT":0.0,
    "question":"Can C1(C(=O)Nc(cccc2[N+](=O)[O-])c2)=Cc(cccc3CC=C)c3OC1=O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":60433
  },
  {
    "COADD_ID":"CO-ADD:0259883",
    "INHIB_AVE":2.56,
    "SMILES":"C1(C)(C(OCC)=O)C=C(C(=O)N1c2ccccc2)Nc(cc3)ccc3C(O)=O",
    "HIT":0.0,
    "question":"Can exposure to C1(C)(C(OCC)=O)C=C(C(=O)N1c2ccccc2)Nc(cc3)ccc3C(O)=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":46604
  },
  {
    "COADD_ID":"CO-ADD:0319201",
    "INHIB_AVE":2.06,
    "SMILES":"c1(NC(=O)c(ccc(c2Cl)Cl)c2)sc(c(C)c1C(OCC)=O)C(C)=O",
    "HIT":0.0,
    "question":"Can c1(NC(=O)c(ccc(c2Cl)Cl)c2)sc(c(C)c1C(OCC)=O)C(C)=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":48810
  },
  {
    "COADD_ID":"CO-ADD:0161298",
    "INHIB_AVE":-2.38,
    "SMILES":"c(C(=O)Nc(cccc1C(F)(F)F)c1)(c2N)sc3c2cc(c4n3)CCCCC4",
    "HIT":0.0,
    "question":"Does c(C(=O)Nc(cccc1C(F)(F)F)c1)(c2N)sc3c2cc(c4n3)CCCCC4 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":65494
  },
  {
    "COADD_ID":"CO-ADD:0252662",
    "INHIB_AVE":5.79,
    "SMILES":"C1(C(Oc(c23)cc(c(C)c2)NCC)=CC(=[N+]([H])CC)C(C)=C1)=C3c4ccccc4C(OCC)=O.C(C(C)C)(=O)[O-]",
    "HIT":0.0,
    "question":"Does C1(C(Oc(c23)cc(c(C)c2)NCC)=CC(=[N+]([H])CC)C(C)=C1)=C3c4ccccc4C(OCC)=O.C(C(C)C)(=O)[O-] demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":32171
  },
  {
    "COADD_ID":"CO-ADD:0223606",
    "INHIB_AVE":1.37,
    "SMILES":"c1(CC)c(\\C=N\\O)c(CC)cc(CC)c1\\C=N\\O",
    "HIT":0.0,
    "question":"Is c1(CC)c(\\C=N\\O)c(CC)cc(CC)c1\\C=N\\O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":51852
  },
  {
    "COADD_ID":"CO-ADD:0277817",
    "INHIB_AVE":5.76,
    "SMILES":"N1(C2c3cccs3)C(S\\C(=C\\c(cc4Br)cc(c4O)Br)\\C1=O)=NC(C)=C2C(OCC)=O",
    "HIT":0.0,
    "question":"Is N1(C2c3cccs3)C(S\\C(=C\\c(cc4Br)cc(c4O)Br)\\C1=O)=NC(C)=C2C(OCC)=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":32267
  },
  {
    "COADD_ID":"CO-ADD:0255999",
    "INHIB_AVE":4.77,
    "SMILES":"C(C(OC)=O)(C1c(cccc2[N+](=O)[O-])c2)=C(N)N(C(CCCC3=O)=C13)c4ccc(cc4)Cl",
    "HIT":0.0,
    "question":"Does C(C(OC)=O)(C1c(cccc2[N+](=O)[O-])c2)=C(N)N(C(CCCC3=O)=C13)c4ccc(cc4)Cl demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":36688
  },
  {
    "COADD_ID":"CO-ADD:0159853",
    "INHIB_AVE":-7.63,
    "SMILES":"[O-][N+](C1=CC2=C(C=C1)N=C(SC3=CC=C(\/C=N\/C4=CC=C(C=C4)C5=CC=CC=C5)O3)S2)=O",
    "HIT":0.0,
    "question":"Is [O-][N+](C1=CC2=C(C=C1)N=C(SC3=CC=C(\/C=N\/C4=CC=C(C=C4)C5=CC=CC=C5)O3)S2)=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":76235
  },
  {
    "COADD_ID":"CO-ADD:0136186",
    "INHIB_AVE":1.77,
    "SMILES":"Clc1ccc(nc(C)c2[N+](=O)[O-])n2c1",
    "HIT":0.0,
    "question":"Is Clc1ccc(nc(C)c2[N+](=O)[O-])n2c1 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":50149
  },
  {
    "COADD_ID":"CO-ADD:0330817",
    "INHIB_AVE":7.07,
    "SMILES":"c1(C(OCC)=O)sc2c(c(C)cc(C)n2)c1n3cccc3",
    "HIT":0.0,
    "question":"Can c1(C(OCC)=O)sc2c(c(C)cc(C)n2)c1n3cccc3 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":26693
  },
  {
    "COADD_ID":"CO-ADD:0283411",
    "INHIB_AVE":-2.74,
    "SMILES":"N1(c2ccccc2)C(=O)c3c(N=C1SCC(=O)N4CCCCC4)cccc3",
    "HIT":0.0,
    "question":"Can exposure to N1(c2ccccc2)C(=O)c3c(N=C1SCC(=O)N4CCCCC4)cccc3 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":66481
  },
  {
    "COADD_ID":"CO-ADD:0256631",
    "INHIB_AVE":2.62,
    "SMILES":"c1([nH]c(c2n1)ccc(c2)\\N=C\\c3cccc(Br)c3)c4ccc(cc4Cl)Cl",
    "HIT":0.0,
    "question":"Does c1([nH]c(c2n1)ccc(c2)\\N=C\\c3cccc(Br)c3)c4ccc(cc4Cl)Cl demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":46324
  },
  {
    "COADD_ID":"CO-ADD:0328135",
    "INHIB_AVE":-3.42,
    "SMILES":"S(=O)(=O)(c(cccc1C(=O)Nc2ccccc2)c1)N(CC3)CCN3C45CC6CC(CC(C6)C4)C5",
    "HIT":0.0,
    "question":"Is S(=O)(=O)(c(cccc1C(=O)Nc2ccccc2)c1)N(CC3)CCN3C45CC6CC(CC(C6)C4)C5 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":68305
  },
  {
    "COADD_ID":"CO-ADD:0255746",
    "INHIB_AVE":0.0,
    "SMILES":"C1(C(=O)OCC2CCCO2)=C(C)NC(=O)NC1c(cc3)ccc3[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Can exposure to C1(C(=O)OCC2CCCO2)=C(C)NC(=O)NC1c(cc3)ccc3[N+](=O)[O-] lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":82710
  },
  {
    "COADD_ID":"CO-ADD:0135740",
    "INHIB_AVE":1.75,
    "SMILES":"N1([H])c(cccc2)c2C=Cc3c1cccc3",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound N1([H])c(cccc2)c2C=Cc3c1cccc3?",
    "answer":"No",
    "_id":50209
  },
  {
    "COADD_ID":"CO-ADD:0254678",
    "INHIB_AVE":-14.81,
    "SMILES":"c(C#N)(c(\\C(\\C#N)=C\\c1cc(Br)ccc1OCc2ccccc2)nn3c4ccccc4)c3N",
    "HIT":0.0,
    "question":"Can exposure to c(C#N)(c(\\C(\\C#N)=C\\c1cc(Br)ccc1OCc2ccccc2)nn3c4ccccc4)c3N lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":81237
  },
  {
    "COADD_ID":"CO-ADD:0232691",
    "INHIB_AVE":4.8,
    "SMILES":"C1(C(=O)OC2CCCC(C)C2)=C(C)NC(=O)NC1c3ccc(cc3)OCCC",
    "HIT":0.0,
    "question":"Does C1(C(=O)OC2CCCC(C)C2)=C(C)NC(=O)NC1c3ccc(cc3)OCCC demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":36531
  },
  {
    "COADD_ID":"CO-ADD:0248108",
    "INHIB_AVE":17.92,
    "SMILES":"c1(SCC(=O)NC(C)CNC(CSc2nc(C)cc(C)n2)=O)nc(C)cc(C)n1",
    "HIT":0.0,
    "question":"Is c1(SCC(=O)NC(C)CNC(CSc2nc(C)cc(C)n2)=O)nc(C)cc(C)n1 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":4369
  },
  {
    "COADD_ID":"CO-ADD:0250396",
    "INHIB_AVE":3.94,
    "SMILES":"c1(\\N=C\\c(ccc2c3ccc(c(Cl)c3)C)o2)c(c4ccc(c(OC)c4)O)nc(cccc5)n15",
    "HIT":0.0,
    "question":"Does treatment with c1(\\N=C\\c(ccc2c3ccc(c(Cl)c3)C)o2)c(c4ccc(c(OC)c4)O)nc(cccc5)n15 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":40440
  },
  {
    "COADD_ID":"CO-ADD:0293522",
    "INHIB_AVE":4.48,
    "SMILES":"C(F)(F)(F)c(cccc1N(CC2)CCN2C(=O)COc3ccc(cc3C)C)c1",
    "HIT":0.0,
    "question":"Can C(F)(F)(F)c(cccc1N(CC2)CCN2C(=O)COc3ccc(cc3C)C)c1 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":38011
  },
  {
    "COADD_ID":"CO-ADD:0217530",
    "INHIB_AVE":6.61,
    "SMILES":"[N+](=O)([O-])c1cc(ccc1Cl)\\C=N\\NC(=O)\\C(\\NC(c2ccccc2)=O)=C\/c3cccs3",
    "HIT":0.0,
    "question":"Does the proposed molecule [N+](=O)([O-])c1cc(ccc1Cl)\\C=N\\NC(=O)\\C(\\NC(c2ccccc2)=O)=C\/c3cccs3 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":28690
  },
  {
    "COADD_ID":"CO-ADD:0252243",
    "INHIB_AVE":-4.1,
    "SMILES":"C(C(OC)=O)(C1c2ccc(cc2)Cl)=C(N)N(C(CCCC3=O)=C13)c(cc4)ccc4S(N)(=O)=O",
    "HIT":0.0,
    "question":"Is C(C(OC)=O)(C1c2ccc(cc2)Cl)=C(N)N(C(CCCC3=O)=C13)c(cc4)ccc4S(N)(=O)=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":69974
  },
  {
    "COADD_ID":"CO-ADD:0250152",
    "INHIB_AVE":-2.24,
    "SMILES":"N1(CC(O)=O)C(=O)\\C(\\SC1=S)=C\\c(cc(Cl)cc2Cl)c2OC",
    "HIT":0.0,
    "question":"Does N1(CC(O)=O)C(=O)\\C(\\SC1=S)=C\\c(cc(Cl)cc2Cl)c2OC demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":65073
  },
  {
    "COADD_ID":"CO-ADD:0229243",
    "INHIB_AVE":10.17,
    "SMILES":"C1(C)(CC2OC(CC)=O)C(C[C@@H](OC(CC)=O)[C@]1(C)C(=O)COC(CC)=O)C([C@]23F)CCC(=CC(=O)C=C4)C34C",
    "HIT":0.0,
    "question":"Is C1(C)(CC2OC(CC)=O)C(C[C@@H](OC(CC)=O)[C@]1(C)C(=O)COC(CC)=O)C([C@]23F)CCC(=CC(=O)C=C4)C34C capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":16569
  },
  {
    "COADD_ID":"CO-ADD:0255332",
    "INHIB_AVE":-2.36,
    "SMILES":"C(C1c2ccccc2)(C3=C\\C(\\C(=O)O3)=N\\c4ccccc4)=C(O)C(N1c5ccccc5)=O",
    "HIT":0.0,
    "question":"Does C(C1c2ccccc2)(C3=C\\C(\\C(=O)O3)=N\\c4ccccc4)=C(O)C(N1c5ccccc5)=O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":65430
  },
  {
    "COADD_ID":"CO-ADD:0324435",
    "INHIB_AVE":-0.1,
    "SMILES":"c12c(nnc(SCc(cc3)ccc3C(OC)=O)n1)c4c(cccc4)n2C",
    "HIT":0.0,
    "question":"Is c12c(nnc(SCc(cc3)ccc3C(OC)=O)n1)c4c(cccc4)n2C capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":57874
  },
  {
    "COADD_ID":"CO-ADD:0241347",
    "INHIB_AVE":-1.03,
    "SMILES":"C(c1ccccc1)(=O)C(CCCCC(CN(CC2)CCO2)C(c3ccccc3)=O)CN(CC4)CCO4.Cl.Cl",
    "HIT":0.0,
    "question":"Does C(c1ccccc1)(=O)C(CCCCC(CN(CC2)CCO2)C(c3ccccc3)=O)CN(CC4)CCO4.Cl.Cl demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":61210
  },
  {
    "COADD_ID":"CO-ADD:0242440",
    "INHIB_AVE":-5.43,
    "SMILES":"C(=O)(c1ccc(cc1)OCCC(C)C)NC(c2ccccc2)CC(=O)[O-]",
    "HIT":0.0,
    "question":"Can exposure to C(=O)(c1ccc(cc1)OCCC(C)C)NC(c2ccccc2)CC(=O)[O-] lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":72698
  },
  {
    "COADD_ID":"CO-ADD:0162360",
    "INHIB_AVE":-7.58,
    "SMILES":"C(=O)(c1ccc(cc1)NC(CCCCC)=O)NC(C)(C)C",
    "HIT":0.0,
    "question":"Does treatment with C(=O)(c1ccc(cc1)NC(CCCCC)=O)NC(C)(C)C result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":76177
  },
  {
    "COADD_ID":"CO-ADD:0257783",
    "INHIB_AVE":-2.69,
    "SMILES":"C(=N\/c1cccc(C)c1)(\/S\\C(\\C2=O)=C\\c(cc3)ccc3N(C)C)\\N2",
    "HIT":0.0,
    "question":"Is C(=N\/c1cccc(C)c1)(\/S\\C(\\C2=O)=C\\c(cc3)ccc3N(C)C)\\N2 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":66375
  },
  {
    "COADD_ID":"CO-ADD:0240106",
    "INHIB_AVE":16.93,
    "SMILES":"C[C@]1(CC2)[C@@]3([H])[C@@](C=C[C@@H]3OC(C4=CC=CC=C4)=O)([H])[C@]2(C5=CC=C(C(F)(F)F)C=C5)O1",
    "HIT":0.0,
    "question":"Does treatment with C[C@]1(CC2)[C@@]3([H])[C@@](C=C[C@@H]3OC(C4=CC=CC=C4)=O)([H])[C@]2(C5=CC=C(C(F)(F)F)C=C5)O1 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":5353
  },
  {
    "COADD_ID":"CO-ADD:0236653",
    "INHIB_AVE":-2.03,
    "SMILES":"S(c1ccccc1)(=O)(=O)N(CC(=O)Nc(cc2)ccc2C(OC)=O)c3c(OC)ccc(OC)c3",
    "HIT":0.0,
    "question":"Can exposure to S(c1ccccc1)(=O)(=O)N(CC(=O)Nc(cc2)ccc2C(OC)=O)c3c(OC)ccc(OC)c3 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":64428
  },
  {
    "COADD_ID":"CO-ADD:0257693",
    "INHIB_AVE":5.23,
    "SMILES":"N1(c2ccccc2OC(CCCCCCC)=O)C(=O)C(C(C(c3c4cccc3)c(c56)cccc5)C1=O)C46",
    "HIT":0.0,
    "question":"Does treatment with N1(c2ccccc2OC(CCCCCCC)=O)C(=O)C(C(C(c3c4cccc3)c(c56)cccc5)C1=O)C46 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":34615
  },
  {
    "COADD_ID":"CO-ADD:0279055",
    "INHIB_AVE":2.57,
    "SMILES":"n1c(c2ccc(cc2)C)csc1\\C(\\C#N)=N\\Nc(cc3)ccc3OC",
    "HIT":0.0,
    "question":"Does n1c(c2ccc(cc2)C)csc1\\C(\\C#N)=N\\Nc(cc3)ccc3OC show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":46574
  },
  {
    "COADD_ID":"CO-ADD:0223367",
    "INHIB_AVE":3.72,
    "SMILES":"c1(SCC(=O)N\\N=C\\c(cc2)ccc2[N+](=O)[O-])sc(c3n1)cccc3",
    "HIT":0.0,
    "question":"Is c1(SCC(=O)N\\N=C\\c(cc2)ccc2[N+](=O)[O-])sc(c3n1)cccc3 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":41414
  },
  {
    "COADD_ID":"CO-ADD:0300341",
    "INHIB_AVE":9.37,
    "SMILES":"C12(c3c(NC1=O)cccc3)SC(C(=O)N2c4ccc(cc4)Br)C",
    "HIT":0.0,
    "question":"Does C12(c3c(NC1=O)cccc3)SC(C(=O)N2c4ccc(cc4)Br)C show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":18839
  },
  {
    "COADD_ID":"CO-ADD:0290813",
    "INHIB_AVE":-10.34,
    "SMILES":"C1(C#N)(C#N)C(N)=C(C#N)C(C2C1c3c4c([nH]c3)cccc4)=CCC(C(C)(C)C)C2",
    "HIT":0.0,
    "question":"Can C1(C#N)(C#N)C(N)=C(C#N)C(C2C1c3c4c([nH]c3)cccc4)=CCC(C(C)(C)C)C2 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":78941
  },
  {
    "COADD_ID":"CO-ADD:0227812",
    "INHIB_AVE":6.37,
    "SMILES":"n(c1c(n2)cccc1)(c3N)c2c(c(c4ccc(c(OC)c4)O)c3C#N)C#N",
    "HIT":0.0,
    "question":"Can n(c1c(n2)cccc1)(c3N)c2c(c(c4ccc(c(OC)c4)O)c3C#N)C#N effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":29661
  },
  {
    "COADD_ID":"CO-ADD:0149615",
    "INHIB_AVE":-0.94,
    "SMILES":"ClC1=C2C(NC(C(C)C2)=O)=C3C(N=C(CCCC4)C4=C3N)=N1",
    "HIT":0.0,
    "question":"Can ClC1=C2C(NC(C(C)C2)=O)=C3C(N=C(CCCC4)C4=C3N)=N1 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":60915
  },
  {
    "COADD_ID":"CO-ADD:0252820",
    "INHIB_AVE":7.34,
    "SMILES":"c1(c(C)c(s2)C)c2NC(=S)N(C)C1=O",
    "HIT":0.0,
    "question":"Can exposure to c1(c(C)c(s2)C)c2NC(=S)N(C)C1=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":25708
  },
  {
    "COADD_ID":"CO-ADD:0156950",
    "INHIB_AVE":8.05,
    "SMILES":"O=C(C)N(C1(CCCC1)O2)N=C2C(C=C3)=CC=C3C(C)(C)C",
    "HIT":0.0,
    "question":"Is O=C(C)N(C1(CCCC1)O2)N=C2C(C=C3)=CC=C3C(C)(C)C capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":23015
  },
  {
    "COADD_ID":"CO-ADD:0329185",
    "INHIB_AVE":-1.08,
    "SMILES":"c12c([nH]nc1c3cc(sc3C)C)OC(=C(C#N)C24c5c(NC4=O)cccc5)N",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c12c([nH]nc1c3cc(sc3C)C)OC(=C(C#N)C24c5c(NC4=O)cccc5)N?",
    "answer":"No",
    "_id":61359
  },
  {
    "COADD_ID":"CO-ADD:0255130",
    "INHIB_AVE":-22.22,
    "SMILES":"S(=O)(=O)(N(c1ccccc1)CC(=O)N\\N=C\\c(ccc(c23)OCO2)c3)c4ccccc4[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Is S(=O)(=O)(N(c1ccccc1)CC(=O)N\\N=C\\c(ccc(c23)OCO2)c3)c4ccccc4[N+](=O)[O-] capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":82328
  },
  {
    "COADD_ID":"CO-ADD:0287589",
    "INHIB_AVE":-0.2,
    "SMILES":"c1(ccnn1C)C(O\\N=C\\c(ccc(c2CN(CC3)CCO3)OC)c2)=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(ccnn1C)C(O\\N=C\\c(ccc(c2CN(CC3)CCO3)OC)c2)=O?",
    "answer":"No",
    "_id":58253
  },
  {
    "COADD_ID":"CO-ADD:0277927",
    "INHIB_AVE":5.72,
    "SMILES":"C(O)(c1ccc(cc1)NC(=O)Nc2ccccc2)(C(OC)=O)C(F)(F)F",
    "HIT":0.0,
    "question":"Does C(O)(c1ccc(cc1)NC(=O)Nc2ccccc2)(C(OC)=O)C(F)(F)F show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":32458
  },
  {
    "COADD_ID":"CO-ADD:0235815",
    "INHIB_AVE":-5.67,
    "SMILES":"C1(C(=O)OCC(=O)c(cc2)ccc2[N+](=O)[O-])=Cc3c(OC1=O)cccc3",
    "HIT":0.0,
    "question":"Does the proposed molecule C1(C(=O)OCC(=O)c(cc2)ccc2[N+](=O)[O-])=Cc3c(OC1=O)cccc3 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":73115
  },
  {
    "COADD_ID":"CO-ADD:0225251",
    "INHIB_AVE":21.74,
    "SMILES":"N12C(C=CC(SC3CCCCC3)=N1)=NN(CC(=O)Nc4ccc(cc4Cl)C)C2=O",
    "HIT":0.0,
    "question":"Can N12C(C=CC(SC3CCCCC3)=N1)=NN(CC(=O)Nc4ccc(cc4Cl)C)C2=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":2024
  },
  {
    "COADD_ID":"CO-ADD:0232524",
    "INHIB_AVE":7.8,
    "SMILES":"[N+](=O)([O-])c1ccc(c(Br)c1)OCC(=O)N\\N=C\\c(cc2)cc(c2OC(=O)c3cccc(OC)c3)OC",
    "HIT":0.0,
    "question":"Does [N+](=O)([O-])c1ccc(c(Br)c1)OCC(=O)N\\N=C\\c(cc2)cc(c2OC(=O)c3cccc(OC)c3)OC demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":23947
  },
  {
    "COADD_ID":"CO-ADD:0253887",
    "INHIB_AVE":7.74,
    "SMILES":"S1(=O)(=O)c(cccc2)c2C(Nc(ccc(c3CN(CC)CC)OC(c4ccccc4)=O)c3)=N1.Cl",
    "HIT":0.0,
    "question":"Does S1(=O)(=O)c(cccc2)c2C(Nc(ccc(c3CN(CC)CC)OC(c4ccccc4)=O)c3)=N1.Cl show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":24205
  },
  {
    "COADD_ID":"CO-ADD:0165060",
    "INHIB_AVE":0.38,
    "SMILES":"Cc1ccc(cc1)S(=O)(=O)NC(=O)NN1CCCCCC1",
    "HIT":0.0,
    "question":"Is Cc1ccc(cc1)S(=O)(=O)NC(=O)NN1CCCCCC1 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":55955
  },
  {
    "COADD_ID":"CO-ADD:0245967",
    "INHIB_AVE":1.48,
    "SMILES":"c1(SCC(=O)Nc(cc2)ccc2CC)sc3c(ccc(c3)\\N=C\\c(c(O)ccc4[N+](=O)[O-])c4)n1",
    "HIT":0.0,
    "question":"Does c1(SCC(=O)Nc(cc2)ccc2CC)sc3c(ccc(c3)\\N=C\\c(c(O)ccc4[N+](=O)[O-])c4)n1 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":51356
  },
  {
    "COADD_ID":"CO-ADD:0287189",
    "INHIB_AVE":-2.77,
    "SMILES":"c1(OC(N)=C(C2c3cc(OC)ccc3OC)C#N)c2c(nn1c4ccc(cc4)C)C",
    "HIT":0.0,
    "question":"Can exposure to c1(OC(N)=C(C2c3cc(OC)ccc3OC)C#N)c2c(nn1c4ccc(cc4)C)C lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":66566
  },
  {
    "COADD_ID":"CO-ADD:0249766",
    "INHIB_AVE":-1.37,
    "SMILES":"c1(Nc(cc2)ccc2OC)nc(N\\N=C\\c(ccc3c4ccc(cc4)Cl)o3)nc(NCc5ccco5)n1.Cl",
    "HIT":0.0,
    "question":"Can exposure to c1(Nc(cc2)ccc2OC)nc(N\\N=C\\c(ccc3c4ccc(cc4)Cl)o3)nc(NCc5ccco5)n1.Cl lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":62321
  },
  {
    "COADD_ID":"CO-ADD:0233496",
    "INHIB_AVE":4.98,
    "SMILES":"C(COc(ccc(c1C)C)c1)(=O)N\\N=C\\c2ccc(cc2Cl)Cl",
    "HIT":0.0,
    "question":"Does treatment with C(COc(ccc(c1C)C)c1)(=O)N\\N=C\\c2ccc(cc2Cl)Cl result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":35745
  },
  {
    "COADD_ID":"CO-ADD:0332235",
    "INHIB_AVE":15.56,
    "SMILES":"C1(C(OCCSC)=O)=C(C)NC(NC1c2ccccc2C)=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C1(C(OCCSC)=O)=C(C)NC(NC1c2ccccc2C)=O?",
    "answer":"No",
    "_id":6861
  },
  {
    "COADD_ID":"CO-ADD:0283822",
    "INHIB_AVE":5.68,
    "SMILES":"N1(C(OC)=O)c2c([C@]([H])(CN(C)CC3)[C@]13[H])cc(C)cc2.Cl",
    "HIT":0.0,
    "question":"Does the proposed molecule N1(C(OC)=O)c2c([C@]([H])(CN(C)CC3)[C@]13[H])cc(C)cc2.Cl exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":32604
  },
  {
    "COADD_ID":"CO-ADD:0311023",
    "INHIB_AVE":2.3,
    "SMILES":"C(=O)(N\\C(=C\/c1cccc(F)c1)\\C(=O)NCc(cccn2)c2)c3ccccc3Br",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C(=O)(N\\C(=C\/c1cccc(F)c1)\\C(=O)NCc(cccn2)c2)c3ccccc3Br?",
    "answer":"No",
    "_id":47754
  },
  {
    "COADD_ID":"CO-ADD:0235391",
    "INHIB_AVE":14.88,
    "SMILES":"c1(C#N)c(CCC(C2)C(C)(C)C)c2sc1\\N=C\\c3ccc(I)s3",
    "HIT":0.0,
    "question":"Can c1(C#N)c(CCC(C2)C(C)(C)C)c2sc1\\N=C\\c3ccc(I)s3 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":7754
  },
  {
    "COADD_ID":"CO-ADD:0230740",
    "INHIB_AVE":3.52,
    "SMILES":"C(N(CC)CC)(=S)Oc(cc1)ccc1C(=O)Nc(cc2)ccc2I",
    "HIT":0.0,
    "question":"Does treatment with C(N(CC)CC)(=S)Oc(cc1)ccc1C(=O)Nc(cc2)ccc2I result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":42288
  },
  {
    "COADD_ID":"CO-ADD:0227225",
    "INHIB_AVE":10.13,
    "SMILES":"c1(C)c(Br)cc(cc1Br)NCC(=O)N\\N=C\\c2ccccc2F",
    "HIT":0.0,
    "question":"Is c1(C)c(Br)cc(cc1Br)NCC(=O)N\\N=C\\c2ccccc2F effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":16664
  },
  {
    "COADD_ID":"CO-ADD:0222896",
    "INHIB_AVE":5.87,
    "SMILES":"c1(c(Br)cc(cc1Br)OC)\\N=C\\c2cc(Br)ccc2OC",
    "HIT":0.0,
    "question":"Does the proposed molecule c1(c(Br)cc(cc1Br)OC)\\N=C\\c2cc(Br)ccc2OC exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":31798
  },
  {
    "COADD_ID":"CO-ADD:0277892",
    "INHIB_AVE":7.32,
    "SMILES":"C1(=COc(c2C1=O)ccc(OC)c2)C(=O)c3ccccc3C",
    "HIT":0.0,
    "question":"Does the proposed molecule C1(=COc(c2C1=O)ccc(OC)c2)C(=O)c3ccccc3C exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":25779
  },
  {
    "COADD_ID":"CO-ADD:0257197",
    "INHIB_AVE":0.9,
    "SMILES":"C(\/Sc(cc1)ccc1[N+](=O)[O-])(\\C(C(C#N)C#N)c2cccs2)=C(\/O)\\c3ccccc3",
    "HIT":0.0,
    "question":"Can exposure to C(\/Sc(cc1)ccc1[N+](=O)[O-])(\\C(C(C#N)C#N)c2cccs2)=C(\/O)\\c3ccccc3 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":53874
  },
  {
    "COADD_ID":"CO-ADD:0136111",
    "INHIB_AVE":4.01,
    "SMILES":"c1cn([H])c(CC(NC)=O)c1C(OCC)=O",
    "HIT":0.0,
    "question":"Can c1cn([H])c(CC(NC)=O)c1C(OCC)=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":40127
  },
  {
    "COADD_ID":"CO-ADD:0291330",
    "INHIB_AVE":-0.36,
    "SMILES":"n1(C(=O)CSc2nnc(Cc3ccccc3)n2c4ccccc4)c5c(c(CCCC6)c16)cccc5",
    "HIT":0.0,
    "question":"Does treatment with n1(C(=O)CSc2nnc(Cc3ccccc3)n2c4ccccc4)c5c(c(CCCC6)c16)cccc5 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":58855
  },
  {
    "COADD_ID":"CO-ADD:0236277",
    "INHIB_AVE":15.26,
    "SMILES":"c1(ccccc1NC(c2ccccc2)=O)C(=O)N\\N=C\\c(c3c([nH]4)cccc3)c4",
    "HIT":0.0,
    "question":"Does c1(ccccc1NC(c2ccccc2)=O)C(=O)N\\N=C\\c(c3c([nH]4)cccc3)c4 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":7252
  },
  {
    "COADD_ID":"CO-ADD:0256228",
    "INHIB_AVE":2.64,
    "SMILES":"c1([N+](=O)[O-])ncn(C)c1Sc2[nH]c(c3n2)cc(c(C)c3)C",
    "HIT":0.0,
    "question":"Can c1([N+](=O)[O-])ncn(C)c1Sc2[nH]c(c3n2)cc(c(C)c3)C effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":46246
  },
  {
    "COADD_ID":"CO-ADD:0149269",
    "INHIB_AVE":11.28,
    "SMILES":"COc(cc(c(c(c(c1C2)C(O2)=O)c3cc(c(c(OC)c3)OC4)O4)c5)n1)c5",
    "HIT":0.0,
    "question":"Is COc(cc(c(c(c(c1C2)C(O2)=O)c3cc(c(c(OC)c3)OC4)O4)c5)n1)c5 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":13935
  },
  {
    "COADD_ID":"CO-ADD:0242352",
    "INHIB_AVE":4.91,
    "SMILES":"c1(C#N)c(c2ccc(cc2)Cl)cc(nc1SCc(cc3)ccn3)c4cccs4",
    "HIT":0.0,
    "question":"Is c1(C#N)c(c2ccc(cc2)Cl)cc(nc1SCc(cc3)ccn3)c4cccs4 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":36048
  },
  {
    "COADD_ID":"CO-ADD:0220404",
    "INHIB_AVE":5.13,
    "SMILES":"c1(C)c(Br)cc(cc1Br)NCC(=O)N\\N=C\\c2cc(OC)ccc2O",
    "HIT":0.0,
    "question":"Does treatment with c1(C)c(Br)cc(cc1Br)NCC(=O)N\\N=C\\c2cc(OC)ccc2O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":35051
  },
  {
    "COADD_ID":"CO-ADD:0258119",
    "INHIB_AVE":4.58,
    "SMILES":"C(=N\/c(cc1)ccc1C)(\/S\\C(\\C2=O)=C\\c(ccc(c3OC)OCc4cccc(C)c4)c3)\\N2",
    "HIT":0.0,
    "question":"Does the proposed molecule C(=N\/c(cc1)ccc1C)(\/S\\C(\\C2=O)=C\\c(ccc(c3OC)OCc4cccc(C)c4)c3)\\N2 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":37536
  },
  {
    "COADD_ID":"CO-ADD:0218495",
    "INHIB_AVE":81.41,
    "SMILES":"C(F)(F)(C(F)(F)C(F)(F)C(F)(F)F)C(F)(F)C(F)(F)C(=O)N\\N=C\\c(cc1)ccc1O",
    "HIT":0.0,
    "question":"Does the proposed molecule C(F)(F)(C(F)(F)C(F)(F)C(F)(F)F)C(F)(F)C(F)(F)C(=O)N\\N=C\\c(cc1)ccc1O exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":403
  },
  {
    "COADD_ID":"CO-ADD:0252562",
    "INHIB_AVE":2.63,
    "SMILES":"C(O)(Cc1ccccc1)(C(C)C2)CC(N2C)C",
    "HIT":0.0,
    "question":"Does treatment with C(O)(Cc1ccccc1)(C(C)C2)CC(N2C)C result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":46281
  },
  {
    "COADD_ID":"CO-ADD:0160682",
    "INHIB_AVE":6.19,
    "SMILES":"O=C(N\/N=C\/C1=CC(OCO2)=C2C=C1)CSC3=CC=C4C(C=CC=C4)=N3",
    "HIT":0.0,
    "question":"Does the proposed molecule O=C(N\/N=C\/C1=CC(OCO2)=C2C=C1)CSC3=CC=C4C(C=CC=C4)=N3 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":30476
  },
  {
    "COADD_ID":"CO-ADD:0229167",
    "INHIB_AVE":6.33,
    "SMILES":"n1c(COC(=O)C(CC(C)C)NC(c2ccccc2)=O)c(oc1c3ccccc3)COC(=O)C(CC(C)C)NC(c4ccccc4)=O",
    "HIT":0.0,
    "question":"Can n1c(COC(=O)C(CC(C)C)NC(c2ccccc2)=O)c(oc1c3ccccc3)COC(=O)C(CC(C)C)NC(c4ccccc4)=O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":29859
  },
  {
    "COADD_ID":"CO-ADD:0226734",
    "INHIB_AVE":10.4,
    "SMILES":"N1(c(ccs2)c2C(N3CCc4ccccc4)=O)C3=NN(Cc5ccccc5F)C1=O",
    "HIT":0.0,
    "question":"Can exposure to N1(c(ccs2)c2C(N3CCc4ccccc4)=O)C3=NN(Cc5ccccc5F)C1=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":15974
  },
  {
    "COADD_ID":"CO-ADD:0284281",
    "INHIB_AVE":9.88,
    "SMILES":"c([N+](=O)[O-])(c(C)nn1C(=O)Cc(cc2)ccc2Cl)c1C",
    "HIT":0.0,
    "question":"Can exposure to c([N+](=O)[O-])(c(C)nn1C(=O)Cc(cc2)ccc2Cl)c1C lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":17329
  },
  {
    "COADD_ID":"CO-ADD:0294413",
    "INHIB_AVE":-4.2,
    "SMILES":"c1(nc(c2ccc(cc2)Cl)cc3C(F)(F)F)n3nc(C(=O)Nc(cc(Oc4ccccc4)cc5[N+](=O)[O-])c5)c1Cl",
    "HIT":0.0,
    "question":"Is c1(nc(c2ccc(cc2)Cl)cc3C(F)(F)F)n3nc(C(=O)Nc(cc(Oc4ccccc4)cc5[N+](=O)[O-])c5)c1Cl effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":70208
  },
  {
    "COADD_ID":"CO-ADD:0135927",
    "INHIB_AVE":-6.92,
    "SMILES":"[H]N1CCN([H])c(cc(c2ccccc2)c3)c1c3",
    "HIT":0.0,
    "question":"Is [H]N1CCN([H])c(cc(c2ccccc2)c3)c1c3 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":75201
  },
  {
    "COADD_ID":"CO-ADD:0295766",
    "INHIB_AVE":2.37,
    "SMILES":"c1(NC(COc2ccc(cc2F)F)=O)sc(c3c1C(OCC)=O)CC(CC3)CC",
    "HIT":0.0,
    "question":"Can c1(NC(COc2ccc(cc2F)F)=O)sc(c3c1C(OCC)=O)CC(CC3)CC effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":47442
  },
  {
    "COADD_ID":"CO-ADD:0157615",
    "INHIB_AVE":-13.28,
    "SMILES":"O=C(O\/1)C(C(NC(C)=C2)=O)=C2C1=C\/C3=CC=C(C(OC)=C3)O",
    "HIT":0.0,
    "question":"Can O=C(O\/1)C(C(NC(C)=C2)=O)=C2C1=C\/C3=CC=C(C(OC)=C3)O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":80665
  },
  {
    "COADD_ID":"CO-ADD:0327828",
    "INHIB_AVE":9.01,
    "SMILES":"C(=O)(c1c(cccc1F)F)NC(=O)Nc2ccccc2SC(F)(F)C(F)(F)F",
    "HIT":0.0,
    "question":"Is C(=O)(c1c(cccc1F)F)NC(=O)Nc2ccccc2SC(F)(F)C(F)(F)F capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":19857
  },
  {
    "COADD_ID":"CO-ADD:0232613",
    "INHIB_AVE":3.54,
    "SMILES":"S(NC)(=O)(=O)c1ccccc1C(=O)N\\N=C\\c2cc(Br)cc(OC)c2OC",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound S(NC)(=O)(=O)c1ccccc1C(=O)N\\N=C\\c2cc(Br)cc(OC)c2OC?",
    "answer":"No",
    "_id":42219
  },
  {
    "COADD_ID":"CO-ADD:0290431",
    "INHIB_AVE":-2.97,
    "SMILES":"C1(C(C(C)C)=O)=Cc(cccc2[N+](=O)[O-])c2OC1N(CC3)CCO3",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C1(C(C(C)C)=O)=Cc(cccc2[N+](=O)[O-])c2OC1N(CC3)CCO3?",
    "answer":"No",
    "_id":67190
  },
  {
    "COADD_ID":"CO-ADD:0136070",
    "INHIB_AVE":6.53,
    "SMILES":"O=C1C=C(C(C)(CCC2)C(=C1)C2(C)C)OCCO",
    "HIT":0.0,
    "question":"Does O=C1C=C(C(C)(CCC2)C(=C1)C2(C)C)OCCO demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":28982
  },
  {
    "COADD_ID":"CO-ADD:0235371",
    "INHIB_AVE":-0.89,
    "SMILES":"n1(c2cc(C)n1)c(cc(n3)C)n3c(cc(C)n4)n24",
    "HIT":0.0,
    "question":"Does n1(c2cc(C)n1)c(cc(n3)C)n3c(cc(C)n4)n24 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":60763
  },
  {
    "COADD_ID":"CO-ADD:0217411",
    "INHIB_AVE":2.53,
    "SMILES":"[N+](=O)([O-])c(ccc(c1c2ccc(\\C=N\\c3c(Cl)ccc(Cl)c3)o2)Cl)c1",
    "HIT":0.0,
    "question":"Does [N+](=O)([O-])c(ccc(c1c2ccc(\\C=N\\c3c(Cl)ccc(Cl)c3)o2)Cl)c1 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":46729
  },
  {
    "COADD_ID":"CO-ADD:0226989",
    "INHIB_AVE":8.13,
    "SMILES":"N1(c(ccs2)c2C(N3Cc4ccco4)=O)C3=NN(CC(=O)NC(C)CC)C1=O",
    "HIT":0.0,
    "question":"Can exposure to N1(c(ccs2)c2C(N3Cc4ccco4)=O)C3=NN(CC(=O)NC(C)CC)C1=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":22709
  },
  {
    "COADD_ID":"CO-ADD:0307047",
    "INHIB_AVE":-3.29,
    "SMILES":"c1(cc(F)c(cc1N(CC2)CCN2)N3CCCC3)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Does treatment with c1(cc(F)c(cc1N(CC2)CCN2)N3CCCC3)[N+](=O)[O-] result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":67963
  },
  {
    "COADD_ID":"CO-ADD:0248200",
    "INHIB_AVE":-1.44,
    "SMILES":"N1(c2ccc(c(C)c2)C)C(=O)\\C(\\SC1=S)=C\\c3ccco3",
    "HIT":0.0,
    "question":"Can N1(c2ccc(c(C)c2)C)C(=O)\\C(\\SC1=S)=C\\c3ccco3 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":62567
  },
  {
    "COADD_ID":"CO-ADD:0244436",
    "INHIB_AVE":0.13,
    "SMILES":"n1c(C)cc(C)[nH]1.Br",
    "HIT":0.0,
    "question":"Does n1c(C)cc(C)[nH]1.Br demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":56970
  },
  {
    "COADD_ID":"CO-ADD:0312308",
    "INHIB_AVE":33.96,
    "SMILES":"c1(cccc(cccc2)c12)C(NCCOc3ccccc3F)=O",
    "HIT":0.0,
    "question":"Does c1(cccc(cccc2)c12)C(NCCOc3ccccc3F)=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":643
  },
  {
    "COADD_ID":"CO-ADD:0164674",
    "INHIB_AVE":6.25,
    "SMILES":"OC[C@H]1O[C@@H](Oc2c(oc3cc(O)cc(O)c3c2=O)-c2ccc(O)c(O)c2)[C@H](O)[C@@H](O)[C@H]1O",
    "HIT":0.0,
    "question":"Does treatment with OC[C@H]1O[C@@H](Oc2c(oc3cc(O)cc(O)c3c2=O)-c2ccc(O)c(O)c2)[C@H](O)[C@@H](O)[C@H]1O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":30179
  },
  {
    "COADD_ID":"CO-ADD:0234061",
    "INHIB_AVE":1.68,
    "SMILES":"c1(ccccc1Cl)C(=O)N\\N=C(\\C)\/C(C)(C)C",
    "HIT":0.0,
    "question":"Does the proposed molecule c1(ccccc1Cl)C(=O)N\\N=C(\\C)\/C(C)(C)C exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":50495
  },
  {
    "COADD_ID":"CO-ADD:0223515",
    "INHIB_AVE":15.05,
    "SMILES":"N1(c2ccc(c(C)c2)C)C(=O)\\C(\\C(C)=N1)=C\/NNc(ccc(c3C)C)c3",
    "HIT":0.0,
    "question":"Can exposure to N1(c2ccc(c(C)c2)C)C(=O)\\C(\\C(C)=N1)=C\/NNc(ccc(c3C)C)c3 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":7538
  },
  {
    "COADD_ID":"CO-ADD:0328444",
    "INHIB_AVE":12.44,
    "SMILES":"N1(C)C(C)(C)CC(CC1(C)C)NC(=O)c2cc[nH]n2",
    "HIT":0.0,
    "question":"Does N1(C)C(C)(C)CC(CC1(C)C)NC(=O)c2cc[nH]n2 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":11583
  },
  {
    "COADD_ID":"CO-ADD:0277695",
    "INHIB_AVE":4.47,
    "SMILES":"c(OC(=O)C=C1C)(c2C)c1cc3c2occ3c4ccccc4",
    "HIT":0.0,
    "question":"Does c(OC(=O)C=C1C)(c2C)c1cc3c2occ3c4ccccc4 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":38036
  },
  {
    "COADD_ID":"CO-ADD:0254695",
    "INHIB_AVE":-14.82,
    "SMILES":"c1(nc(c(C(C)=O)s1)C)N2C(c3ccc(cc3)F)CC(c4cccs4)=N2.Cl",
    "HIT":0.0,
    "question":"Does treatment with c1(nc(c(C(C)=O)s1)C)N2C(c3ccc(cc3)F)CC(c4cccs4)=N2.Cl result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":81238
  },
  {
    "COADD_ID":"CO-ADD:0160372",
    "INHIB_AVE":-3.41,
    "SMILES":"[O-][N+](C1=CC([N+]([O-])=O)=CC(NC(C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(NC2=CC([N+]([O-])=O)=CC([N+]([O-])=O)=C2C)=O)=O)=C1C)=O",
    "HIT":0.0,
    "question":"Is [O-][N+](C1=CC([N+]([O-])=O)=CC(NC(C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(NC2=CC([N+]([O-])=O)=CC([N+]([O-])=O)=C2C)=O)=O)=C1C)=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":68269
  },
  {
    "COADD_ID":"CO-ADD:0294578",
    "INHIB_AVE":-10.87,
    "SMILES":"c1(c2c(sc1N)CCC2)C(=O)Nc(cc3)ccc3C",
    "HIT":0.0,
    "question":"Does c1(c2c(sc1N)CCC2)C(=O)Nc(cc3)ccc3C demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":79329
  },
  {
    "COADD_ID":"CO-ADD:0319790",
    "INHIB_AVE":0.99,
    "SMILES":"c1(NC(=O)c2ccc(c(OC)c2)OC)sc(c3c1C(OCC)=O)CCCCC3",
    "HIT":0.0,
    "question":"Does treatment with c1(NC(=O)c2ccc(c(OC)c2)OC)sc(c3c1C(OCC)=O)CCCCC3 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":53474
  },
  {
    "COADD_ID":"CO-ADD:0283709",
    "INHIB_AVE":-8.68,
    "SMILES":"N(c(cc1)ccc1OC)C(C)c2ccccc2",
    "HIT":0.0,
    "question":"Is N(c(cc1)ccc1OC)C(C)c2ccccc2 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":77504
  },
  {
    "COADD_ID":"CO-ADD:0241222",
    "INHIB_AVE":6.1,
    "SMILES":"N1(CCC1=O)C2(CCCCC2)C(=O)Nc3cccc(C)c3",
    "HIT":0.0,
    "question":"Does N1(CCC1=O)C2(CCCCC2)C(=O)Nc3cccc(C)c3 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":30819
  },
  {
    "COADD_ID":"CO-ADD:0227128",
    "INHIB_AVE":-4.88,
    "SMILES":"c12c(c3c(cccc3)[nH]1)nnc(SCC=C)n2",
    "HIT":0.0,
    "question":"Does the proposed molecule c12c(c3c(cccc3)[nH]1)nnc(SCC=C)n2 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":71621
  },
  {
    "COADD_ID":"CO-ADD:0164008",
    "INHIB_AVE":-5.08,
    "SMILES":"O=C(N(CC1CC2=CC=CC=C2)OC1=O)OCC3=CC=CC=C3",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound O=C(N(CC1CC2=CC=CC=C2)OC1=O)OCC3=CC=CC=C3?",
    "answer":"No",
    "_id":72031
  },
  {
    "COADD_ID":"CO-ADD:0247389",
    "INHIB_AVE":8.71,
    "SMILES":"n1(nnc(C(=O)N\\N=C\\CCc2ccccc2)c1CN(CC)CC)c3nonc3N",
    "HIT":0.0,
    "question":"Does the proposed molecule n1(nnc(C(=O)N\\N=C\\CCc2ccccc2)c1CN(CC)CC)c3nonc3N exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":20807
  },
  {
    "COADD_ID":"CO-ADD:0301282",
    "INHIB_AVE":-6.78,
    "SMILES":"c1(SCCOc2ccccc2OC)nc(c3n1CC(N)=O)cccc3",
    "HIT":0.0,
    "question":"Is c1(SCCOc2ccccc2OC)nc(c3n1CC(N)=O)cccc3 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":74998
  },
  {
    "COADD_ID":"CO-ADD:0234718",
    "INHIB_AVE":3.81,
    "SMILES":"[N+](=O)([O-])c1c(OC)ccc(\\C(\\C)=N\\NC(CNC(=O)c2cccc(F)c2)=O)c1",
    "HIT":0.0,
    "question":"Is [N+](=O)([O-])c1c(OC)ccc(\\C(\\C)=N\\NC(CNC(=O)c2cccc(F)c2)=O)c1 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":41028
  },
  {
    "COADD_ID":"CO-ADD:0228705",
    "INHIB_AVE":10.72,
    "SMILES":"N1(c2ccc(cc2)OCCC)C(=O)CC(N(CC3)CCN3c(cc4)ccc4[N+](=O)[O-])C1=O",
    "HIT":0.0,
    "question":"Is N1(c2ccc(cc2)OCCC)C(=O)CC(N(CC3)CCN3c(cc4)ccc4[N+](=O)[O-])C1=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":15181
  },
  {
    "COADD_ID":"CO-ADD:0166052",
    "INHIB_AVE":6.45,
    "SMILES":"[N+](=O)([O-])c1ccc(cc1)\\C=N\\NC(=O)C(C2)CC2=C",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound [N+](=O)([O-])c1ccc(cc1)\\C=N\\NC(=O)C(C2)CC2=C?",
    "answer":"No",
    "_id":29307
  },
  {
    "COADD_ID":"CO-ADD:0160318",
    "INHIB_AVE":-0.83,
    "SMILES":"[O-][N+](C(C=C1[N+]([O-])=O)=C(C=C1)SC2=CC3=CC=CC=C3C=C2)=O",
    "HIT":0.0,
    "question":"Does the proposed molecule [O-][N+](C(C=C1[N+]([O-])=O)=C(C=C1)SC2=CC3=CC=CC=C3C=C2)=O exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":60542
  },
  {
    "COADD_ID":"CO-ADD:0260123",
    "INHIB_AVE":5.28,
    "SMILES":"C(C(OCC)=O)(C1c(cccc2[N+](=O)[O-])c2)=C(C)N(C(C)=C1C(OCC)=O)c3ccc(cc3)Cl",
    "HIT":0.0,
    "question":"Can C(C(OCC)=O)(C1c(cccc2[N+](=O)[O-])c2)=C(C)N(C(C)=C1C(OCC)=O)c3ccc(cc3)Cl effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":34397
  },
  {
    "COADD_ID":"CO-ADD:0323965",
    "INHIB_AVE":2.05,
    "SMILES":"S(NCCOC(C1)(C2)CC(CC2CC13)C3)(=O)(=O)c4c(C)ccc(c4)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Does the proposed molecule S(NCCOC(C1)(C2)CC(CC2CC13)C3)(=O)(=O)c4c(C)ccc(c4)[N+](=O)[O-] exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":48868
  },
  {
    "COADD_ID":"CO-ADD:0256299",
    "INHIB_AVE":-1.32,
    "SMILES":"c(C#N)(c(N)n(n1)CCO)c1\\C(\\C#N)=C\\c(cc2Br)cc(c2OCc(cc3)ccc3C)Br",
    "HIT":0.0,
    "question":"Does c(C#N)(c(N)n(n1)CCO)c1\\C(\\C#N)=C\\c(cc2Br)cc(c2OCc(cc3)ccc3C)Br show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":62156
  },
  {
    "COADD_ID":"CO-ADD:0253520",
    "INHIB_AVE":7.71,
    "SMILES":"c1(SCC(=O)N\\N=C\\c(cc2)ccc2OCC(=O)OC(C)(C)C)ncccn1",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(SCC(=O)N\\N=C\\c(cc2)ccc2OCC(=O)OC(C)(C)C)ncccn1?",
    "answer":"No",
    "_id":24303
  },
  {
    "COADD_ID":"CO-ADD:0157773",
    "INHIB_AVE":2.29,
    "SMILES":"O=C(NCC(N\/N=C\/C1=C(O)C=CC(Br)=C1)=O)C2=CC(OC)=C(OC)C=C2",
    "HIT":0.0,
    "question":"Can exposure to O=C(NCC(N\/N=C\/C1=C(O)C=CC(Br)=C1)=O)C2=CC(OC)=C(OC)C=C2 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":47787
  },
  {
    "COADD_ID":"CO-ADD:0320988",
    "INHIB_AVE":7.1,
    "SMILES":"C(CSCc(cc1)ccc1F)(=O)Nc2ccccc2",
    "HIT":0.0,
    "question":"Does C(CSCc(cc1)ccc1F)(=O)Nc2ccccc2 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":26615
  },
  {
    "COADD_ID":"CO-ADD:0259411",
    "INHIB_AVE":1.89,
    "SMILES":"C(=O)(c1cccnc1Oc(cc2)ccc2F)NC(C)(C(C)C)C(N)=O",
    "HIT":0.0,
    "question":"Does the proposed molecule C(=O)(c1cccnc1Oc(cc2)ccc2F)NC(C)(C(C)C)C(N)=O exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":49587
  },
  {
    "COADD_ID":"CO-ADD:0155813",
    "INHIB_AVE":2.27,
    "SMILES":"O=C(C1=CC=CC=C1)NC(CC2=CC(O)=CC=C2)C(OC)=O",
    "HIT":0.0,
    "question":"Does O=C(C1=CC=CC=C1)NC(CC2=CC(O)=CC=C2)C(OC)=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":47916
  },
  {
    "COADD_ID":"CO-ADD:0255835",
    "INHIB_AVE":18.68,
    "SMILES":"C(=O)(c1ccc(cc1)F)NCc(ccc(c23)OCO2)c3",
    "HIT":0.0,
    "question":"Is C(=O)(c1ccc(cc1)F)NCc(ccc(c23)OCO2)c3 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":3770
  },
  {
    "COADD_ID":"CO-ADD:0300063",
    "INHIB_AVE":13.29,
    "SMILES":"C(=C\\c(cc1OC)cc(c1O)I)(\/C(=O)NC(N2C)=O)\\C2=O",
    "HIT":0.0,
    "question":"Can C(=C\\c(cc1OC)cc(c1O)I)(\/C(=O)NC(N2C)=O)\\C2=O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":10110
  },
  {
    "COADD_ID":"CO-ADD:0277943",
    "INHIB_AVE":5.72,
    "SMILES":"C(=O)(c1ccc(cc1)OCC)NCC(OCC)=O",
    "HIT":0.0,
    "question":"Does the proposed molecule C(=O)(c1ccc(cc1)OCC)NCC(OCC)=O exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":32459
  },
  {
    "COADD_ID":"CO-ADD:0247761",
    "INHIB_AVE":4.79,
    "SMILES":"c1(ncnc(N\\N=C\\c(cc2)ccc2OCCCCCCC)c1)N(CC3)CCO3",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(ncnc(N\\N=C\\c(cc2)ccc2OCCCCCCC)c1)N(CC3)CCO3?",
    "answer":"No",
    "_id":36616
  },
  {
    "COADD_ID":"CO-ADD:0225536",
    "INHIB_AVE":-4.99,
    "SMILES":"c12n(c3c(cccc3)nc1SCc4c(C)oc(c5cccc(Cl)c5)n4)c(nn2)C",
    "HIT":0.0,
    "question":"Can c12n(c3c(cccc3)nc1SCc4c(C)oc(c5cccc(Cl)c5)n4)c(nn2)C act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":71854
  },
  {
    "COADD_ID":"CO-ADD:0327960",
    "INHIB_AVE":-1.08,
    "SMILES":"C(O)(c(cc1OC)cc(c1O)OC)(C(F)(F)F)C(F)(F)F",
    "HIT":0.0,
    "question":"Can C(O)(c(cc1OC)cc(c1O)OC)(C(F)(F)F)C(F)(F)F act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":61367
  },
  {
    "COADD_ID":"CO-ADD:0253922",
    "INHIB_AVE":-1.47,
    "SMILES":"N1(CC(CC1C(=O)Nc2ccccc2OC)O)C(=O)Oc3ccccc3",
    "HIT":0.0,
    "question":"Does the proposed molecule N1(CC(CC1C(=O)Nc2ccccc2OC)O)C(=O)Oc3ccccc3 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":62631
  },
  {
    "COADD_ID":"CO-ADD:0148922",
    "INHIB_AVE":7.95,
    "SMILES":"c1(nc(c2n1CC(=O)Nc3ccccc3Cl)cccc2)c4nonc4N",
    "HIT":0.0,
    "question":"Can c1(nc(c2n1CC(=O)Nc3ccccc3Cl)cccc2)c4nonc4N act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":23406
  },
  {
    "COADD_ID":"CO-ADD:0157996",
    "INHIB_AVE":-13.17,
    "SMILES":"N#CC1=C(N)SC(N)=C(C#N)C1C2=CC=C(C=C2)[N+]([O-])=O",
    "HIT":0.0,
    "question":"Is N#CC1=C(N)SC(N)=C(C#N)C1C2=CC=C(C=C2)[N+]([O-])=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":80594
  },
  {
    "COADD_ID":"CO-ADD:0319351",
    "INHIB_AVE":2.09,
    "SMILES":"C(=O)(c1cccc(SC)c1)Nc2c(Cl)cc(c(F)c2)F",
    "HIT":0.0,
    "question":"Can exposure to C(=O)(c1cccc(SC)c1)Nc2c(Cl)cc(c(F)c2)F lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":48669
  },
  {
    "COADD_ID":"CO-ADD:0287326",
    "INHIB_AVE":13.16,
    "SMILES":"N1(C(CCC2CCCCC2)=O)C(C)CC(c(cccc3)c13)Nc4ccccc4",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound N1(C(CCC2CCCCC2)=O)C(C)CC(c(cccc3)c13)Nc4ccccc4?",
    "answer":"No",
    "_id":10309
  },
  {
    "COADD_ID":"CO-ADD:0283816",
    "INHIB_AVE":7.87,
    "SMILES":"S(=O)(=O)(N(CC)CC)c1csc(C(=O)Oc(cc2)ccc2[N+](=O)[O-])c1",
    "HIT":0.0,
    "question":"Does treatment with S(=O)(=O)(N(CC)CC)c1csc(C(=O)Oc(cc2)ccc2[N+](=O)[O-])c1 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":23672
  },
  {
    "COADD_ID":"CO-ADD:0247672",
    "INHIB_AVE":0.99,
    "SMILES":"c1(c(Cl)cc(cc1Cl)Cl)NC(=S)NC(=O)\\C=C\\c2ccccc2",
    "HIT":0.0,
    "question":"Can c1(c(Cl)cc(cc1Cl)Cl)NC(=S)NC(=O)\\C=C\\c2ccccc2 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":53478
  },
  {
    "COADD_ID":"CO-ADD:0244843",
    "INHIB_AVE":10.87,
    "SMILES":"C(C)N(C(=S)N1CC)C(C1N2)N3C(S\\C(=C(\/C4=O)\\c5c(cccc5)N4CCc(c6)cccc6)\\C3=O)=N2",
    "HIT":0.0,
    "question":"Does the proposed molecule C(C)N(C(=S)N1CC)C(C1N2)N3C(S\\C(=C(\/C4=O)\\c5c(cccc5)N4CCc(c6)cccc6)\\C3=O)=N2 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":14836
  },
  {
    "COADD_ID":"CO-ADD:0137712",
    "INHIB_AVE":-5.23,
    "SMILES":"c(c(nc(NCc(ccc1c2OCO1)c2)o3)n3)(c4N)non4",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c(c(nc(NCc(ccc1c2OCO1)c2)o3)n3)(c4N)non4?",
    "answer":"No",
    "_id":72328
  },
  {
    "COADD_ID":"CO-ADD:0305790",
    "INHIB_AVE":-6.55,
    "SMILES":"c1(NC(COc(cc2)ccc2I)=O)sc(c(C)c1C(OCC)=O)C(C)=O",
    "HIT":0.0,
    "question":"Is c1(NC(COc(cc2)ccc2I)=O)sc(c(C)c1C(OCC)=O)C(C)=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":74637
  },
  {
    "COADD_ID":"CO-ADD:0242450",
    "INHIB_AVE":22.95,
    "SMILES":"S(=O)(=O)(c1ccc(c2c1)cccc2)N(CC3)CCN3c(cc4)ccc4[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Does S(=O)(=O)(c1ccc(c2c1)cccc2)N(CC3)CCN3c(cc4)ccc4[N+](=O)[O-] demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":1631
  },
  {
    "COADD_ID":"CO-ADD:0158586",
    "INHIB_AVE":2.79,
    "SMILES":"S=C(N(C1=CC=CC=C1)C\/2=O)N(C3=CC=C(C)C=C3)C(C2=C\\C4=CC=C(C=C4)C(C)C)=O",
    "HIT":0.0,
    "question":"Does S=C(N(C1=CC=CC=C1)C\/2=O)N(C3=CC=C(C)C=C3)C(C2=C\\C4=CC=C(C=C4)C(C)C)=O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":45604
  },
  {
    "COADD_ID":"CO-ADD:0253665",
    "INHIB_AVE":7.65,
    "SMILES":"c12c(cccc1C(F)(F)F)C3C(C(C(O)=O)N2)CC=C3",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c12c(cccc1C(F)(F)F)C3C(C(C(O)=O)N2)CC=C3?",
    "answer":"No",
    "_id":24502
  },
  {
    "COADD_ID":"CO-ADD:0319556",
    "INHIB_AVE":3.32,
    "SMILES":"N1(C(=O)\\C(\\SC1=N)=C\/c(ccc2c3cc(Cl)ccc3[N+](=O)[O-])o2)c4nonc4N",
    "HIT":0.0,
    "question":"Can exposure to N1(C(=O)\\C(\\SC1=N)=C\/c(ccc2c3cc(Cl)ccc3[N+](=O)[O-])o2)c4nonc4N lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":43156
  },
  {
    "COADD_ID":"CO-ADD:0278410",
    "INHIB_AVE":5.76,
    "SMILES":"c(nc(c1ccco1)cc2C(F)(F)F)(c3Br)n2nc3C(=O)N4CCCCC4",
    "HIT":0.0,
    "question":"Is c(nc(c1ccco1)cc2C(F)(F)F)(c3Br)n2nc3C(=O)N4CCCCC4 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":32260
  },
  {
    "COADD_ID":"CO-ADD:0293448",
    "INHIB_AVE":-9.85,
    "SMILES":"C(C(F)(F)F)(C(F)(F)F)(NC(C(C)C)=O)Nc1sc(c2c1C(N)=O)CCCC2",
    "HIT":0.0,
    "question":"Is C(C(F)(F)F)(C(F)(F)F)(NC(C(C)C)=O)Nc1sc(c2c1C(N)=O)CCCC2 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":78591
  },
  {
    "COADD_ID":"CO-ADD:0327924",
    "INHIB_AVE":9.02,
    "SMILES":"c1(N2CCCCC2)nc(OCC)nc(N=[N+]=[N-])n1",
    "HIT":0.0,
    "question":"Does the proposed molecule c1(N2CCCCC2)nc(OCC)nc(N=[N+]=[N-])n1 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":19818
  },
  {
    "COADD_ID":"CO-ADD:0220048",
    "INHIB_AVE":5.03,
    "SMILES":"[N+](=O)([O-])c1ccc(c(Cl)c1)NC(c2ccccc2)=O",
    "HIT":0.0,
    "question":"Does [N+](=O)([O-])c1ccc(c(Cl)c1)NC(c2ccccc2)=O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":35495
  },
  {
    "COADD_ID":"CO-ADD:0256050",
    "INHIB_AVE":7.61,
    "SMILES":"c1(N(CC2)CCO2)nc(N\\N=C\\c3cc(Br)cc(Br)c3OCc4ccc(cc4Cl)Cl)nc(Nc5cc(C)ccc5C)n1.Cl",
    "HIT":0.0,
    "question":"Does c1(N(CC2)CCO2)nc(N\\N=C\\c3cc(Br)cc(Br)c3OCc4ccc(cc4Cl)Cl)nc(Nc5cc(C)ccc5C)n1.Cl show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":24638
  },
  {
    "COADD_ID":"CO-ADD:0163055",
    "INHIB_AVE":-5.13,
    "SMILES":"C(=O)(N\\N=C(\/C)\\CC(=O)NC(C)(C)C)c1cnccn1",
    "HIT":0.0,
    "question":"Can C(=O)(N\\N=C(\/C)\\CC(=O)NC(C)(C)C)c1cnccn1 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":72134
  },
  {
    "COADD_ID":"CO-ADD:0237248",
    "INHIB_AVE":99.38,
    "SMILES":"NC(=N)Nc1ccc(c(Cl)c1)c2oc(cc2)c3ccc(NC(=N)N)cc3Cl.Cl.Cl",
    "HIT":1.0,
    "question":"Does treatment with NC(=N)Nc1ccc(c(Cl)c1)c2oc(cc2)c3ccc(NC(=N)N)cc3Cl.Cl.Cl result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"Yes",
    "_id":86
  },
  {
    "COADD_ID":"CO-ADD:0301921",
    "INHIB_AVE":12.9,
    "SMILES":"C(=C\\c(ccc(c1OCC)OCCOc2ccccc2)c1)(\/C(=O)N(C)C(N3C)=O)\\C3=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C(=C\\c(ccc(c1OCC)OCCOc2ccccc2)c1)(\/C(=O)N(C)C(N3C)=O)\\C3=O?",
    "answer":"No",
    "_id":10758
  },
  {
    "COADD_ID":"CO-ADD:0229663",
    "INHIB_AVE":15.62,
    "SMILES":"c1(\\C=N\\NC(=O)c2ccc(cc2)OCC)cc(Br)ccc1OCC",
    "HIT":0.0,
    "question":"Is c1(\\C=N\\NC(=O)c2ccc(cc2)OCC)cc(Br)ccc1OCC capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":6797
  },
  {
    "COADD_ID":"CO-ADD:0237137",
    "INHIB_AVE":22.55,
    "SMILES":"COC1=C(OCCCCOC2=CC=C(C3=NNN=N3)C=C2)C=C(C([C@@H]4[C@H]5CC=CC4)=NN(C6CCCCCC6)C5=O)C=C1",
    "HIT":0.0,
    "question":"Does treatment with COC1=C(OCCCCOC2=CC=C(C3=NNN=N3)C=C2)C=C(C([C@@H]4[C@H]5CC=CC4)=NN(C6CCCCCC6)C5=O)C=C1 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":1759
  },
  {
    "COADD_ID":"CO-ADD:0288478",
    "INHIB_AVE":-0.23,
    "SMILES":"c1(C(CCO2)CC2)ncc(C)n1C(C3)CCN3.Cl.Cl",
    "HIT":0.0,
    "question":"Does c1(C(CCO2)CC2)ncc(C)n1C(C3)CCN3.Cl.Cl show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":58355
  },
  {
    "COADD_ID":"CO-ADD:0166024",
    "INHIB_AVE":14.79,
    "SMILES":"C(N(CCC)CCC)(=S)Oc(cccc1C(=O)Nc(cc2)ccc2C)c1",
    "HIT":0.0,
    "question":"Does C(N(CCC)CCC)(=S)Oc(cccc1C(=O)Nc(cc2)ccc2C)c1 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":7878
  },
  {
    "COADD_ID":"CO-ADD:0252361",
    "INHIB_AVE":-9.14,
    "SMILES":"C(=C\/C(CC)=O)(\/Sc(c12)ccc(cccc3)c13)\\N2C",
    "HIT":0.0,
    "question":"Does the proposed molecule C(=C\/C(CC)=O)(\/Sc(c12)ccc(cccc3)c13)\\N2C exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":77985
  },
  {
    "COADD_ID":"CO-ADD:0222422",
    "INHIB_AVE":7.44,
    "SMILES":"c(Nc1ccccc1)(nc(N\\N=C\\c(cccn2)c2)nc3Nc4ccccc4)n3",
    "HIT":0.0,
    "question":"Does treatment with c(Nc1ccccc1)(nc(N\\N=C\\c(cccn2)c2)nc3Nc4ccccc4)n3 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":25311
  },
  {
    "COADD_ID":"CO-ADD:0243314",
    "INHIB_AVE":15.9,
    "SMILES":"C12[C@@](C)(C(=O)\\C(=C\\c3cc(OC)c(OC4)c(O4)c3)\\C1)CCC5C2CC[C@@]([H])(CCC6)[C@]5(C)C6",
    "HIT":0.0,
    "question":"Is C12[C@@](C)(C(=O)\\C(=C\\c3cc(OC)c(OC4)c(O4)c3)\\C1)CCC5C2CC[C@@]([H])(CCC6)[C@]5(C)C6 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":6476
  },
  {
    "COADD_ID":"CO-ADD:0215306",
    "INHIB_AVE":7.42,
    "SMILES":"C(C#N)(=C(N)OC(=C12)CCCC1=O)C2c3cccc(OC)c3",
    "HIT":0.0,
    "question":"Does the proposed molecule C(C#N)(=C(N)OC(=C12)CCCC1=O)C2c3cccc(OC)c3 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":25391
  },
  {
    "COADD_ID":"CO-ADD:0254715",
    "INHIB_AVE":5.79,
    "SMILES":"[C@@]1(C)(CC2)C(C[C@@H](C[N+](=O)[O-])[C@@H]1\\C(\\C)=N\/Nc3ccc(cc3[N+](=O)[O-])[N+](=O)[O-])C(C24)CC=C(C[C@@H](O)CC5)[C@@]45C",
    "HIT":0.0,
    "question":"Can [C@@]1(C)(CC2)C(C[C@@H](C[N+](=O)[O-])[C@@H]1\\C(\\C)=N\/Nc3ccc(cc3[N+](=O)[O-])[N+](=O)[O-])C(C24)CC=C(C[C@@H](O)CC5)[C@@]45C effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":32154
  },
  {
    "COADD_ID":"CO-ADD:0231357",
    "INHIB_AVE":1.4,
    "SMILES":"[N+](=O)([O-])c1ccc(cc1)COc(cc2)ccc2\\C=N\\NC(=O)c3ccccc3OC",
    "HIT":0.0,
    "question":"Can [N+](=O)([O-])c1ccc(cc1)COc(cc2)ccc2\\C=N\\NC(=O)c3ccccc3OC effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":51725
  },
  {
    "COADD_ID":"CO-ADD:0252647",
    "INHIB_AVE":1.1,
    "SMILES":"C(NCCc(cc1)ccn1)(=O)C(NCCc(cc2)ccn2)=O",
    "HIT":0.0,
    "question":"Can C(NCCc(cc1)ccn1)(=O)C(NCCc(cc2)ccn2)=O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":53066
  },
  {
    "COADD_ID":"CO-ADD:0290709",
    "INHIB_AVE":-2.89,
    "SMILES":"C(C(c1ccccc1)=O)(C2c3ccc(c(OC)c3)OC)=C(O)C(N2CC4CCCO4)=O",
    "HIT":0.0,
    "question":"Can C(C(c1ccccc1)=O)(C2c3ccc(c(OC)c3)OC)=C(O)C(N2CC4CCCO4)=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":66948
  },
  {
    "COADD_ID":"CO-ADD:0166672",
    "INHIB_AVE":14.82,
    "SMILES":"c1(NC(CSc2nc(C)c(c(C)c2C#N)C)=O)sc(c3n1)cccc3",
    "HIT":0.0,
    "question":"Is c1(NC(CSc2nc(C)c(c(C)c2C#N)C)=O)sc(c3n1)cccc3 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":7831
  },
  {
    "COADD_ID":"CO-ADD:0234529",
    "INHIB_AVE":-2.12,
    "SMILES":"S(c1ccccc1)(=O)(=O)c2cc(C)ccc2C",
    "HIT":0.0,
    "question":"Can S(c1ccccc1)(=O)(=O)c2cc(C)ccc2C act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":64709
  },
  {
    "COADD_ID":"CO-ADD:0219604",
    "INHIB_AVE":9.7,
    "SMILES":"[N+](=O)([O-])c(cc1)ccc1C(=O)Oc(cc2)ccc2\\C=N\\NC(Cc3ccccc3)=O",
    "HIT":0.0,
    "question":"Does treatment with [N+](=O)([O-])c(cc1)ccc1C(=O)Oc(cc2)ccc2\\C=N\\NC(Cc3ccccc3)=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":17881
  },
  {
    "COADD_ID":"CO-ADD:0155069",
    "INHIB_AVE":0.24,
    "SMILES":"O=C(C)O[C@H]1[C@H](SC2=NC=CC=C2)O[C@H](COC(C)=O)[C@@H](COC(C)=O)[C@@H]1OC(C)=O",
    "HIT":0.0,
    "question":"Can O=C(C)O[C@H]1[C@H](SC2=NC=CC=C2)O[C@H](COC(C)=O)[C@@H](COC(C)=O)[C@@H]1OC(C)=O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":56499
  },
  {
    "COADD_ID":"CO-ADD:0304683",
    "INHIB_AVE":12.31,
    "SMILES":"N1(c2ccc(cc2)OC)C(=O)C(Cc3ccccc3)=C(N=C1SCC(=O)Nc4ccccc4)O",
    "HIT":0.0,
    "question":"Does N1(c2ccc(cc2)OC)C(=O)C(Cc3ccccc3)=C(N=C1SCC(=O)Nc4ccccc4)O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":11865
  },
  {
    "COADD_ID":"CO-ADD:0284258",
    "INHIB_AVE":16.83,
    "SMILES":"n12c(nc(cc1C(F)(F)F)c3ccc(cc3)Br)cc(C(=O)Nc(cc(OC)cc4[N+](=O)[O-])c4)n2",
    "HIT":0.0,
    "question":"Does treatment with n12c(nc(cc1C(F)(F)F)c3ccc(cc3)Br)cc(C(=O)Nc(cc(OC)cc4[N+](=O)[O-])c4)n2 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":5438
  },
  {
    "COADD_ID":"CO-ADD:0250161",
    "INHIB_AVE":0.0,
    "SMILES":"C(F)(F)(F)c(ccc(n1)N\\N=C\\c2ccc(cc2O)O)c1",
    "HIT":0.0,
    "question":"Can exposure to C(F)(F)(F)c(ccc(n1)N\\N=C\\c2ccc(cc2O)O)c1 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":82741
  },
  {
    "COADD_ID":"CO-ADD:0155222",
    "INHIB_AVE":-12.87,
    "SMILES":"O=C(C1=CC=CO1)N\/N=C\/C2=CC=C(C(C=C3)=CC=C3Br)O2",
    "HIT":0.0,
    "question":"Can O=C(C1=CC=CO1)N\/N=C\/C2=CC=C(C(C=C3)=CC=C3Br)O2 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":80469
  },
  {
    "COADD_ID":"CO-ADD:0320298",
    "INHIB_AVE":-1.64,
    "SMILES":"C(CSc1cccc(cccn2)c12)(=O)N\\N=C\\c(cc3)ccc3O",
    "HIT":0.0,
    "question":"Is C(CSc1cccc(cccn2)c12)(=O)N\\N=C\\c(cc3)ccc3O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":63202
  },
  {
    "COADD_ID":"CO-ADD:0241634",
    "INHIB_AVE":3.7,
    "SMILES":"c1(cc(c(cc2)ccc2c3ccccc3)nn4)c4c(c5C1=O)cccc5",
    "HIT":0.0,
    "question":"Can c1(cc(c(cc2)ccc2c3ccccc3)nn4)c4c(c5C1=O)cccc5 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":41496
  },
  {
    "COADD_ID":"CO-ADD:0161573",
    "INHIB_AVE":-5.36,
    "SMILES":"c1(\\C=N\\NC(COc(cc2)ccc2Cl)=O)cc(OC)ccc1O",
    "HIT":0.0,
    "question":"Is c1(\\C=N\\NC(COc(cc2)ccc2Cl)=O)cc(OC)ccc1O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":72577
  },
  {
    "COADD_ID":"CO-ADD:0252418",
    "INHIB_AVE":-1.31,
    "SMILES":"c(C(=O)N\\N=C\\c(cc1)ccc1OC(=O)c(ccc(c23)OCO2)c3)(c(C)on4)c4c5ccccc5",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c(C(=O)N\\N=C\\c(cc1)ccc1OC(=O)c(ccc(c23)OCO2)c3)(c(C)on4)c4c5ccccc5?",
    "answer":"No",
    "_id":62114
  },
  {
    "COADD_ID":"CO-ADD:0284046",
    "INHIB_AVE":7.27,
    "SMILES":"C(=N\/c(cccc1C(F)(F)F)c1)(\/SC=C2c3ccc(cc3)CC)\\N2CCCCCCO.Br",
    "HIT":0.0,
    "question":"Can C(=N\/c(cccc1C(F)(F)F)c1)(\/SC=C2c3ccc(cc3)CC)\\N2CCCCCCO.Br act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":25993
  },
  {
    "COADD_ID":"CO-ADD:0233006",
    "INHIB_AVE":22.09,
    "SMILES":"N1(c2ccc(cc2)Cl)CC(CC1=O)C(=O)NCc3ccccc3",
    "HIT":0.0,
    "question":"Does treatment with N1(c2ccc(cc2)Cl)CC(CC1=O)C(=O)NCc3ccccc3 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":1922
  },
  {
    "COADD_ID":"CO-ADD:0327913",
    "INHIB_AVE":0.9,
    "SMILES":"S(=O)(=O)(c1ccc(cc1)Cl)Nc(c(cccc2)c23)cc4c3oc(CCC(C)C5)c45",
    "HIT":0.0,
    "question":"Can exposure to S(=O)(=O)(c1ccc(cc1)Cl)Nc(c(cccc2)c23)cc4c3oc(CCC(C)C5)c45 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":53881
  },
  {
    "COADD_ID":"CO-ADD:0163616",
    "INHIB_AVE":-3.53,
    "SMILES":"c1(\\C=N\\NC(=O)c2cccc(O)c2)cc(Br)cc(Br)c1OCC(O)=O",
    "HIT":0.0,
    "question":"Does c1(\\C=N\\NC(=O)c2cccc(O)c2)cc(Br)cc(Br)c1OCC(O)=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":68607
  },
  {
    "COADD_ID":"CO-ADD:0218505",
    "INHIB_AVE":2.94,
    "SMILES":"C(=O)(Nc(cc1)ccc1OCCCCCCCCCC)Nc(cc2)ccc2c3ccccc3",
    "HIT":0.0,
    "question":"Does treatment with C(=O)(Nc(cc1)ccc1OCCCCCCCCCC)Nc(cc2)ccc2c3ccccc3 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":44930
  },
  {
    "COADD_ID":"CO-ADD:0161409",
    "INHIB_AVE":-12.96,
    "SMILES":"C(F)(F)(COc1ccccc1NC(=O)Nc2cccc(cccc3)c23)C(F)F",
    "HIT":0.0,
    "question":"Does C(F)(F)(COc1ccccc1NC(=O)Nc2cccc(cccc3)c23)C(F)F show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":80512
  },
  {
    "COADD_ID":"CO-ADD:0300008",
    "INHIB_AVE":2.56,
    "SMILES":"c1(C(N)=O)oc(c2c1NC(CSc3ccccc3)=O)cccc2",
    "HIT":0.0,
    "question":"Does c1(C(N)=O)oc(c2c1NC(CSc3ccccc3)=O)cccc2 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":46629
  },
  {
    "COADD_ID":"CO-ADD:0310970",
    "INHIB_AVE":-1.52,
    "SMILES":"C(C(OC)=O)(C(F)(F)F)(NC(c1ccccc1)=O)Nc2sc(c(c3ccccc3)c2C(OCC)=O)CC",
    "HIT":0.0,
    "question":"Is C(C(OC)=O)(C(F)(F)F)(NC(c1ccccc1)=O)Nc2sc(c(c3ccccc3)c2C(OCC)=O)CC capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":62800
  },
  {
    "COADD_ID":"CO-ADD:0226487",
    "INHIB_AVE":14.53,
    "SMILES":"c1(nnc2SC(CC)C(=O)Nc3c(OC)ccc(OC)c3)n2C=CN(c4cccc(OC)c4)C1=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(nnc2SC(CC)C(=O)Nc3c(OC)ccc(OC)c3)n2C=CN(c4cccc(OC)c4)C1=O?",
    "answer":"No",
    "_id":8207
  },
  {
    "COADD_ID":"CO-ADD:0287460",
    "INHIB_AVE":2.51,
    "SMILES":"C(C#N)(C(c(cc1)ccc1N(C)C)C2=C(N3c4ccc(cc4F)Br)CCCC2=O)=C3N",
    "HIT":0.0,
    "question":"Can C(C#N)(C(c(cc1)ccc1N(C)C)C2=C(N3c4ccc(cc4F)Br)CCCC2=O)=C3N effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":46849
  },
  {
    "COADD_ID":"CO-ADD:0228148",
    "INHIB_AVE":14.86,
    "SMILES":"C(CNc1ccc(cc1Br)Br)(=O)N\\N=C\\c2ccc(cc2O)O",
    "HIT":0.0,
    "question":"Does C(CNc1ccc(cc1Br)Br)(=O)N\\N=C\\c2ccc(cc2O)O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":7773
  },
  {
    "COADD_ID":"CO-ADD:0256339",
    "INHIB_AVE":1.27,
    "SMILES":"C1(C2c3ccc(c(OC)c3)OC)=C(c4c(cccc4)OC1=O)OC(N)=C2[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Is C1(C2c3ccc(c(OC)c3)OC)=C(c4c(cccc4)OC1=O)OC(N)=C2[N+](=O)[O-] effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":52296
  },
  {
    "COADD_ID":"CO-ADD:0254985",
    "INHIB_AVE":-3.86,
    "SMILES":"c1(SCC(=O)Nc(cc2)ccc2CC)sc3c(ccc(c3)NC(=O)c4ccc(cc4)OCCCCCCCCCC)n1",
    "HIT":0.0,
    "question":"Can exposure to c1(SCC(=O)Nc(cc2)ccc2CC)sc3c(ccc(c3)NC(=O)c4ccc(cc4)OCCCCCCCCCC)n1 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":69421
  },
  {
    "COADD_ID":"CO-ADD:0163831",
    "INHIB_AVE":3.59,
    "SMILES":"N(=C(\/CCC)\\c1ccc(cc1)Cl)\/NC(=O)Cc2cccc(cccc3)c23",
    "HIT":0.0,
    "question":"Does treatment with N(=C(\/CCC)\\c1ccc(cc1)Cl)\/NC(=O)Cc2cccc(cccc3)c23 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":41973
  },
  {
    "COADD_ID":"CO-ADD:0235198",
    "INHIB_AVE":1.31,
    "SMILES":"c1(c2ccccc2C)oc(c3n1)ccc(c3)\\N=C\\c(cc4)ccc4OCc5ccccc5",
    "HIT":0.0,
    "question":"Is c1(c2ccccc2C)oc(c3n1)ccc(c3)\\N=C\\c(cc4)ccc4OCc5ccccc5 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":52110
  },
  {
    "COADD_ID":"CO-ADD:0161388",
    "INHIB_AVE":11.43,
    "SMILES":"n(c(SCC(=O)Nc(cc1)ccc1Br)nc(n2)SCC(=O)Nc(cc3)ccc3Br)c2SCC(=O)Nc(cc4)ccc4Br",
    "HIT":0.0,
    "question":"Is n(c(SCC(=O)Nc(cc1)ccc1Br)nc(n2)SCC(=O)Nc(cc3)ccc3Br)c2SCC(=O)Nc(cc4)ccc4Br capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":13615
  },
  {
    "COADD_ID":"CO-ADD:0163525",
    "INHIB_AVE":7.0,
    "SMILES":"c1(cc(\\C=N\\NC(COc2ccccc2C)=O)cc(OC)c1O)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Can c1(cc(\\C=N\\NC(COc2ccccc2C)=O)cc(OC)c1O)[N+](=O)[O-] effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":26978
  },
  {
    "COADD_ID":"CO-ADD:0300451",
    "INHIB_AVE":-11.49,
    "SMILES":"N1(c(cccc2C(F)(F)F)c2)C(=O)C(N(CCc(ccc(c3OC)OC)c3)C1=S)CC(NC)=O",
    "HIT":0.0,
    "question":"Can N1(c(cccc2C(F)(F)F)c2)C(=O)C(N(CCc(ccc(c3OC)OC)c3)C1=S)CC(NC)=O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":79708
  },
  {
    "COADD_ID":"CO-ADD:0156942",
    "INHIB_AVE":4.14,
    "SMILES":"ClC1=NC(NC2=CC=CC=C2)=NC(NC3=CC=CC=C3)=N1",
    "HIT":0.0,
    "question":"Can ClC1=NC(NC2=CC=CC=C2)=NC(NC3=CC=CC=C3)=N1 act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":39556
  },
  {
    "COADD_ID":"CO-ADD:0218010",
    "INHIB_AVE":8.12,
    "SMILES":"c1(ccc(\\C=N\\NC(COc(cc2)ccc2Cl)=O)o1)c3cc(Cl)ccc3Cl",
    "HIT":0.0,
    "question":"Does c1(ccc(\\C=N\\NC(COc(cc2)ccc2Cl)=O)o1)c3cc(Cl)ccc3Cl demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":22770
  },
  {
    "COADD_ID":"CO-ADD:0323755",
    "INHIB_AVE":0.92,
    "SMILES":"c(Cn(ccn1)c1)(nnc2Cn(ccn3)c3)n2N",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c(Cn(ccn1)c1)(nnc2Cn(ccn3)c3)n2N?",
    "answer":"No",
    "_id":53815
  },
  {
    "COADD_ID":"CO-ADD:0288806",
    "INHIB_AVE":4.61,
    "SMILES":"c1(ccccc1)C(NCC#C)=O",
    "HIT":0.0,
    "question":"Is c1(ccccc1)C(NCC#C)=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":37402
  },
  {
    "COADD_ID":"CO-ADD:0257003",
    "INHIB_AVE":-1.36,
    "SMILES":"c1(c(ccc(c1)C(F)(F)F)Oc(cccc2C(NCCOc3c(C)cc(cc3C)C)=O)c2)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Does the proposed molecule c1(c(ccc(c1)C(F)(F)F)Oc(cccc2C(NCCOc3c(C)cc(cc3C)C)=O)c2)[N+](=O)[O-] exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":62257
  },
  {
    "COADD_ID":"CO-ADD:0283340",
    "INHIB_AVE":16.81,
    "SMILES":"N1(CSc(nnc(c23)c4c(cccc4)n2CCC)n3)C(=O)c(c5C1=O)cccc5",
    "HIT":0.0,
    "question":"Can exposure to N1(CSc(nnc(c23)c4c(cccc4)n2CCC)n3)C(=O)c(c5C1=O)cccc5 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":5465
  },
  {
    "COADD_ID":"CO-ADD:0245953",
    "INHIB_AVE":22.66,
    "SMILES":"N(C1c2ccc(cc2)OC)(C(=O)\\C(\\S3)=N\/Nc(cc4)ccc4Br)C3=NC(C)=C1C(OCC)=O",
    "HIT":0.0,
    "question":"Is N(C1c2ccc(cc2)OC)(C(=O)\\C(\\S3)=N\/Nc(cc4)ccc4Br)C3=NC(C)=C1C(OCC)=O capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":1724
  },
  {
    "COADD_ID":"CO-ADD:0165907",
    "INHIB_AVE":18.27,
    "SMILES":"[N+](=O)([O-])c1cccc(c1)NC(=O)C\\C(\\C)=N\\NC(COc(ccc(c2C)Br)c2)=O",
    "HIT":0.0,
    "question":"Can [N+](=O)([O-])c1cccc(c1)NC(=O)C\\C(\\C)=N\\NC(COc(ccc(c2C)Br)c2)=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":4085
  },
  {
    "COADD_ID":"CO-ADD:0288548",
    "INHIB_AVE":5.64,
    "SMILES":"c1(c2ccccc2)ncc(C)n1C(CCCN3)C3",
    "HIT":0.0,
    "question":"Does c1(c2ccccc2)ncc(C)n1C(CCCN3)C3 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":32755
  },
  {
    "COADD_ID":"CO-ADD:0258335",
    "INHIB_AVE":-9.8,
    "SMILES":"c1(NC(CCCCCC)=O)nnc(COc(cc2)ccc2C(C)(C)C)s1",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound c1(NC(CCCCCC)=O)nnc(COc(cc2)ccc2C(C)(C)C)s1?",
    "answer":"No",
    "_id":78555
  },
  {
    "COADD_ID":"CO-ADD:0227347",
    "INHIB_AVE":1.64,
    "SMILES":"c1(ccc(c(cccc2)c12)Br)CC(=O)N\\N=C\\c3cc(Br)ccc3OC",
    "HIT":0.0,
    "question":"Is c1(ccc(c(cccc2)c12)Br)CC(=O)N\\N=C\\c3cc(Br)ccc3OC capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":50723
  },
  {
    "COADD_ID":"CO-ADD:0302180",
    "INHIB_AVE":12.82,
    "SMILES":"c12c(c(c(C)c(O)n1)C)c(nn2c3ccccc3)C",
    "HIT":0.0,
    "question":"Is c12c(c(c(C)c(O)n1)C)c(nn2c3ccccc3)C effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":10903
  },
  {
    "COADD_ID":"CO-ADD:0305891",
    "INHIB_AVE":30.02,
    "SMILES":"c1(NC(=O)C(C)Oc2ccccc2Br)sc(c(C)c1C(OC)=O)C",
    "HIT":0.0,
    "question":"Can exposure to c1(NC(=O)C(C)Oc2ccccc2Br)sc(c(C)c1C(OC)=O)C lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":769
  },
  {
    "COADD_ID":"CO-ADD:0302950",
    "INHIB_AVE":-3.09,
    "SMILES":"N1(CCC(O)=O)C(=O)\\C(\\SC1=S)=C\/c2ccco2",
    "HIT":0.0,
    "question":"Does N1(CCC(O)=O)C(=O)\\C(\\SC1=S)=C\/c2ccco2 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":67485
  },
  {
    "COADD_ID":"CO-ADD:0163354",
    "INHIB_AVE":0.24,
    "SMILES":"c1(OCC(=O)N\\N=C(\/C)\\c2ccc(cc2)OC)c(OC)cc(cc1Br)Br",
    "HIT":0.0,
    "question":"Is c1(OCC(=O)N\\N=C(\/C)\\c2ccc(cc2)OC)c(OC)cc(cc1Br)Br effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":56517
  },
  {
    "COADD_ID":"CO-ADD:0291016",
    "INHIB_AVE":1.93,
    "SMILES":"S(=O)(=O)(N(CC1)CCO1)c2c(C)ccc(Cl)c2",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound S(=O)(=O)(N(CC1)CCO1)c2c(C)ccc(Cl)c2?",
    "answer":"No",
    "_id":49426
  },
  {
    "COADD_ID":"CO-ADD:0249989",
    "INHIB_AVE":5.82,
    "SMILES":"c1(SCC(OCC(COC(CSc2nc(C)cc(C)n2)=O)=O)=O)nc(C)cc(C)n1",
    "HIT":0.0,
    "question":"Can c1(SCC(OCC(COC(CSc2nc(C)cc(C)n2)=O)=O)=O)nc(C)cc(C)n1 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":32040
  },
  {
    "COADD_ID":"CO-ADD:0160048",
    "INHIB_AVE":10.97,
    "SMILES":"O=C(N(C(C=C1)=CC=C1[N+]([O-])=O)C([C@H]2[C@@H]3C45)=O)[C@@H]2[C@@](C=C3)(C6=CC=CC=C6)C5C(N(C(C=C7)=CC=C7[N+]([O-])=O)C4=O)=O",
    "HIT":0.0,
    "question":"Is O=C(N(C(C=C1)=CC=C1[N+]([O-])=O)C([C@H]2[C@@H]3C45)=O)[C@@H]2[C@@](C=C3)(C6=CC=CC=C6)C5C(N(C(C=C7)=CC=C7[N+]([O-])=O)C4=O)=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":14602
  },
  {
    "COADD_ID":"CO-ADD:0300971",
    "INHIB_AVE":1.17,
    "SMILES":"C(=O)(Nc(cccn1)c1)c2ccccc2O",
    "HIT":0.0,
    "question":"Can C(=O)(Nc(cccn1)c1)c2ccccc2O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":52775
  },
  {
    "COADD_ID":"CO-ADD:0217608",
    "INHIB_AVE":6.6,
    "SMILES":"C(COc(cc1)ccc1C(C)CCC)(=O)N\\N=C\\c2cccc(OC)c2OC",
    "HIT":0.0,
    "question":"Can exposure to C(COc(cc1)ccc1C(C)CCC)(=O)N\\N=C\\c2cccc(OC)c2OC lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":28725
  },
  {
    "COADD_ID":"CO-ADD:0228237",
    "INHIB_AVE":1.36,
    "SMILES":"N1C(=O)\\C(\\SC1=N)=C\/c(ccc2c3ccccc3[N+](=O)[O-])o2",
    "HIT":0.0,
    "question":"Does treatment with N1C(=O)\\C(\\SC1=N)=C\/c(ccc2c3ccccc3[N+](=O)[O-])o2 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":51893
  },
  {
    "COADD_ID":"CO-ADD:0285493",
    "INHIB_AVE":1.87,
    "SMILES":"s1c(N)nnc1SCc2ccccc2C#N",
    "HIT":0.0,
    "question":"Is s1c(N)nnc1SCc2ccccc2C#N effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":49670
  },
  {
    "COADD_ID":"CO-ADD:0290731",
    "INHIB_AVE":6.0,
    "SMILES":"S(=O)(=O)(c1ccc(cc1C)Cl)Oc2cccc(ccc(C)n3)c23",
    "HIT":0.0,
    "question":"Can exposure to S(=O)(=O)(c1ccc(cc1C)Cl)Oc2cccc(ccc(C)n3)c23 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":31264
  },
  {
    "COADD_ID":"CO-ADD:0225895",
    "INHIB_AVE":-7.34,
    "SMILES":"N12C(C=CC(c3ccc(cc3)Cl)=N1)=NN(CC(=O)Nc4ccccc4)C2=O",
    "HIT":0.0,
    "question":"Does treatment with N12C(C=CC(c3ccc(cc3)Cl)=N1)=NN(CC(=O)Nc4ccccc4)C2=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":75842
  },
  {
    "COADD_ID":"CO-ADD:0222368",
    "INHIB_AVE":-0.59,
    "SMILES":"n1c2c(oc1c3cccc(I)c3)ccc(c2)\\N=C\\c(ccc(c4[N+](=O)[O-])Cl)c4",
    "HIT":0.0,
    "question":"Does n1c2c(oc1c3cccc(I)c3)ccc(c2)\\N=C\\c(ccc(c4[N+](=O)[O-])Cl)c4 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":59695
  },
  {
    "COADD_ID":"CO-ADD:0259456",
    "INHIB_AVE":13.52,
    "SMILES":"n1(C(CCC(OC(C)C)=O)=O)c2c(nn1)cccc2",
    "HIT":0.0,
    "question":"Is n1(C(CCC(OC(C)C)=O)=O)c2c(nn1)cccc2 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":9729
  },
  {
    "COADD_ID":"CO-ADD:0242762",
    "INHIB_AVE":-3.74,
    "SMILES":"C(=O)(Nc(cccc1NC(=O)c2ccco2)c1)c3ccccc3I",
    "HIT":0.0,
    "question":"Does C(=O)(Nc(cccc1NC(=O)c2ccco2)c1)c3ccccc3I demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":69143
  },
  {
    "COADD_ID":"CO-ADD:0307511",
    "INHIB_AVE":12.67,
    "SMILES":"C12(C#N)C(c(cc3)ccn3)OC4(C(CCCCCCCCCC4)C1(C#N)C#N)OC2=N",
    "HIT":0.0,
    "question":"Is C12(C#N)C(c(cc3)ccn3)OC4(C(CCCCCCCCCC4)C1(C#N)C#N)OC2=N capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":11182
  },
  {
    "COADD_ID":"CO-ADD:0258651",
    "INHIB_AVE":-14.54,
    "SMILES":"N12c(c(C3C(CCC3)C1)c4)c(C5C(CCC5)C2)cc4NC(=O)c6ccccc6OC",
    "HIT":0.0,
    "question":"Can N12c(c(C3C(CCC3)C1)c4)c(C5C(CCC5)C2)cc4NC(=O)c6ccccc6OC act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":81154
  },
  {
    "COADD_ID":"CO-ADD:0257316",
    "INHIB_AVE":2.48,
    "SMILES":"C1(C(OCCSC)=O)=C(C)NC(NC1c(cc2OC)cc(c2O)Br)=O",
    "HIT":0.0,
    "question":"Can C1(C(OCCSC)=O)=C(C)NC(NC1c(cc2OC)cc(c2O)Br)=O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":46947
  },
  {
    "COADD_ID":"CO-ADD:0319098",
    "INHIB_AVE":-6.41,
    "SMILES":"c12c(ccc(CNC(COc(cc3)ccc3C4CCCCC4)=O)c1)OCO2",
    "HIT":0.0,
    "question":"Can exposure to c12c(ccc(CNC(COc(cc3)ccc3C4CCCCC4)=O)c1)OCO2 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":74438
  },
  {
    "COADD_ID":"CO-ADD:0234472",
    "INHIB_AVE":3.84,
    "SMILES":"C(\/C(=O)c1ccccc1O)=C(\/N)\\C(F)(F)F",
    "HIT":0.0,
    "question":"Does treatment with C(\/C(=O)c1ccccc1O)=C(\/N)\\C(F)(F)F result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":40894
  },
  {
    "COADD_ID":"CO-ADD:0235597",
    "INHIB_AVE":-8.13,
    "SMILES":"S(=O)(=O)(N(CC1)CCO1)c2c(OC)ccc(c2)C(=O)Nc3sccn3",
    "HIT":0.0,
    "question":"Can S(=O)(=O)(N(CC1)CCO1)c2c(OC)ccc(c2)C(=O)Nc3sccn3 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":76871
  },
  {
    "COADD_ID":"CO-ADD:0320025",
    "INHIB_AVE":2.04,
    "SMILES":"c12c(CCNC1c3ccc(cc3)F)cc(c(OCC)c2)OCC",
    "HIT":0.0,
    "question":"Does c12c(CCNC1c3ccc(cc3)F)cc(c(OCC)c2)OCC show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":48936
  },
  {
    "COADD_ID":"CO-ADD:0259944",
    "INHIB_AVE":4.63,
    "SMILES":"[C@@H]1([C@@H](CCCCC(OCCC)=O)SC[C@H]1NC(OC)=O)NC(OC)=O",
    "HIT":0.0,
    "question":"Can [C@@H]1([C@@H](CCCCC(OCCC)=O)SC[C@H]1NC(OC)=O)NC(OC)=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":37307
  },
  {
    "COADD_ID":"CO-ADD:0164923",
    "INHIB_AVE":6.56,
    "SMILES":"CCOC(=O)c1cncn1[C@H](C)c1ccccc1",
    "HIT":0.0,
    "question":"Can CCOC(=O)c1cncn1[C@H](C)c1ccccc1 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":28867
  },
  {
    "COADD_ID":"CO-ADD:0327409",
    "INHIB_AVE":7.13,
    "SMILES":"c(NC(CSc1nccn1C)=O)(c(C(N)=O)nn2c3ccccc3)n2",
    "HIT":0.0,
    "question":"Does the proposed molecule c(NC(CSc1nccn1C)=O)(c(C(N)=O)nn2c3ccccc3)n2 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":26504
  },
  {
    "COADD_ID":"CO-ADD:0226737",
    "INHIB_AVE":3.84,
    "SMILES":"N1(c(ccs2)c2C(N3CCc4ccccc4)=O)C3=NN(Cc(cc5)ccc5F)C1=O",
    "HIT":0.0,
    "question":"Does treatment with N1(c(ccs2)c2C(N3CCc4ccccc4)=O)C3=NN(Cc(cc5)ccc5F)C1=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":40880
  },
  {
    "COADD_ID":"CO-ADD:0318897",
    "INHIB_AVE":7.22,
    "SMILES":"C(\/C#N)(\\C(OCCCC)=O)=C\/c(ccc1c2ccc(cc2)Br)o1",
    "HIT":0.0,
    "question":"Does the proposed molecule C(\/C#N)(\\C(OCCCC)=O)=C\/c(ccc1c2ccc(cc2)Br)o1 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":26178
  },
  {
    "COADD_ID":"CO-ADD:0249203",
    "INHIB_AVE":7.69,
    "SMILES":"c12c(c3c(NC(\\C=C\\c4ccccc4)O1)cccc3)nnc(SCCC)n2",
    "HIT":0.0,
    "question":"Does c12c(c3c(NC(\\C=C\\c4ccccc4)O1)cccc3)nnc(SCCC)n2 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":24353
  },
  {
    "COADD_ID":"CO-ADD:0311764",
    "INHIB_AVE":3.29,
    "SMILES":"C(O)(c1cccc(C)c1)(c2cccc(C)c2)C(=O)NNC(CC)c3cccc(C)c3",
    "HIT":0.0,
    "question":"Can C(O)(c1cccc(C)c1)(c2cccc(C)c2)C(=O)NNC(CC)c3cccc(C)c3 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":43329
  },
  {
    "COADD_ID":"CO-ADD:0306110",
    "INHIB_AVE":5.46,
    "SMILES":"N1(CCC(CC1)C)c2ccc(cc2F)C(CC)=O",
    "HIT":0.0,
    "question":"Is N1(CCC(CC1)C)c2ccc(cc2F)C(CC)=O effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":33641
  },
  {
    "COADD_ID":"CO-ADD:0163529",
    "INHIB_AVE":-13.72,
    "SMILES":"c1(cc(\\C=N\\NC(=O)c(ccc(c23)OCCO2)c3)cc(OC)c1O)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Does c1(cc(\\C=N\\NC(=O)c(ccc(c23)OCCO2)c3)cc(OC)c1O)[N+](=O)[O-] demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":80862
  },
  {
    "COADD_ID":"CO-ADD:0148911",
    "INHIB_AVE":19.53,
    "SMILES":"c12c(cc(Br)c(cccc3)c13)C(CC(=O)N2)c(cc4OC)cc(c4OC)Br",
    "HIT":0.0,
    "question":"Does the proposed molecule c12c(cc(Br)c(cccc3)c13)C(CC(=O)N2)c(cc4OC)cc(c4OC)Br exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":3158
  },
  {
    "COADD_ID":"CO-ADD:0312265",
    "INHIB_AVE":-3.1,
    "SMILES":"C(C(OCCSCC)=O)(=C(C)NC(=C12)CC(CC1=O)c3cccs3)C2c4cccs4",
    "HIT":0.0,
    "question":"Does C(C(OCCSCC)=O)(=C(C)NC(=C12)CC(CC1=O)c3cccs3)C2c4cccs4 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":67500
  },
  {
    "COADD_ID":"CO-ADD:0253125",
    "INHIB_AVE":7.66,
    "SMILES":"N(CN1CCC(CC1)C)(C2=S)N=C(N2c3ccccc3)c4ccco4",
    "HIT":0.0,
    "question":"Is N(CN1CCC(CC1)C)(C2=S)N=C(N2c3ccccc3)c4ccco4 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":24459
  },
  {
    "COADD_ID":"CO-ADD:0234387",
    "INHIB_AVE":1.7,
    "SMILES":"N(CC(=O)NNC(=O)C(F)(F)F)(c(cccc1)c12)c(cccc3)c3C2=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound N(CC(=O)NNC(=O)C(F)(F)F)(c(cccc1)c12)c(cccc3)c3C2=O?",
    "answer":"No",
    "_id":50445
  },
  {
    "COADD_ID":"CO-ADD:0228587",
    "INHIB_AVE":3.51,
    "SMILES":"N1(c2ccc(cc2)OCCC)C(=O)CC(N(CC3)CCO3)C1=O",
    "HIT":0.0,
    "question":"Does N1(c2ccc(cc2)OCCC)C(=O)CC(N(CC3)CCO3)C1=O show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":42362
  },
  {
    "COADD_ID":"CO-ADD:0250700",
    "INHIB_AVE":-1.26,
    "SMILES":"S(=O)(=O)(N(CC)CC)c(ccc(c1C(=O)Oc(cccc2OC(=O)c(c(Cl)ccc3S(=O)(=O)N(CC)CC)c3)c2)Cl)c1",
    "HIT":0.0,
    "question":"Does S(=O)(=O)(N(CC)CC)c(ccc(c1C(=O)Oc(cccc2OC(=O)c(c(Cl)ccc3S(=O)(=O)N(CC)CC)c3)c2)Cl)c1 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":61958
  },
  {
    "COADD_ID":"CO-ADD:0293342",
    "INHIB_AVE":-8.35,
    "SMILES":"C(=C(C)NC(=C1C#N)SCC(=O)Nc2ccccc2C)(C(=O)Nc3ccccc3OC)C1c4cccs4",
    "HIT":0.0,
    "question":"Does the proposed molecule C(=C(C)NC(=C1C#N)SCC(=O)Nc2ccccc2C)(C(=O)Nc3ccccc3OC)C1c4cccs4 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":77148
  },
  {
    "COADD_ID":"CO-ADD:0300688",
    "INHIB_AVE":4.47,
    "SMILES":"c1(C2c3ccc(cc3)OC(=O)c4ccco4)c([nH]nc1c(cccc5[N+](=O)[O-])c5)OC(N)=C2C#N",
    "HIT":0.0,
    "question":"Does treatment with c1(C2c3ccc(cc3)OC(=O)c4ccco4)c([nH]nc1c(cccc5[N+](=O)[O-])c5)OC(N)=C2C#N result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":38064
  },
  {
    "COADD_ID":"CO-ADD:0258128",
    "INHIB_AVE":-8.2,
    "SMILES":"N1(C)C(=S)SC(C)(C)C1\\[N+](\\[O-])=C\\c(cccc2[N+](=O)[O-])c2",
    "HIT":0.0,
    "question":"Does the proposed molecule N1(C)C(=S)SC(C)(C)C1\\[N+](\\[O-])=C\\c(cccc2[N+](=O)[O-])c2 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":76961
  },
  {
    "COADD_ID":"CO-ADD:0155330",
    "INHIB_AVE":-13.18,
    "SMILES":"O=C(C1=CC=C(C)C=C1)NC2=NN=C(CCCCC)S2",
    "HIT":0.0,
    "question":"Does the proposed molecule O=C(C1=CC=C(C)C=C1)NC2=NN=C(CCCCC)S2 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":80603
  },
  {
    "COADD_ID":"CO-ADD:0222669",
    "INHIB_AVE":3.82,
    "SMILES":"C(=O)(Nc(cc1)ccc1Nc2ccccc2)C\\C(\\C)=N\\NC(Cc3ccccc3)=O",
    "HIT":0.0,
    "question":"Does treatment with C(=O)(Nc(cc1)ccc1Nc2ccccc2)C\\C(\\C)=N\\NC(Cc3ccccc3)=O result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":40994
  },
  {
    "COADD_ID":"CO-ADD:0260106",
    "INHIB_AVE":-15.96,
    "SMILES":"N1(c2ccccc2)C(=O)C(CC1=O)SCC(N)C(OCC)=O.Cl",
    "HIT":0.0,
    "question":"Does treatment with N1(c2ccccc2)C(=O)C(CC1=O)SCC(N)C(OCC)=O.Cl result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":81540
  },
  {
    "COADD_ID":"CO-ADD:0255320",
    "INHIB_AVE":1.22,
    "SMILES":"C(=N)(N(CC1)CCO1)\\C(\\C#N)=N\\Nc(cc2)ccc2Br",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound C(=N)(N(CC1)CCO1)\\C(\\C#N)=N\\Nc(cc2)ccc2Br?",
    "answer":"No",
    "_id":52526
  },
  {
    "COADD_ID":"CO-ADD:0301518",
    "INHIB_AVE":12.2,
    "SMILES":"N1(c(cccc2C(F)(F)F)c2)C(\\C=C\\c3ccccc3Cl)=Nc(c4C1=O)cccc4",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound N1(c(cccc2C(F)(F)F)c2)C(\\C=C\\c3ccccc3Cl)=Nc(c4C1=O)cccc4?",
    "answer":"No",
    "_id":12064
  },
  {
    "COADD_ID":"CO-ADD:0254425",
    "INHIB_AVE":5.85,
    "SMILES":"c1(cn2)c(CC(C)(C)CC1=O)nc2NC(CC)=O",
    "HIT":0.0,
    "question":"Can exposure to c1(cn2)c(CC(C)(C)CC1=O)nc2NC(CC)=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":31870
  },
  {
    "COADD_ID":"CO-ADD:0162757",
    "INHIB_AVE":2.79,
    "SMILES":"C(NCCOc1ccccc1C)(=O)Nc(cc2)ccc2OCCCCCCCCCC",
    "HIT":0.0,
    "question":"Does C(NCCOc1ccccc1C)(=O)Nc(cc2)ccc2OCCCCCCCCCC show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":45587
  },
  {
    "COADD_ID":"CO-ADD:0156392",
    "INHIB_AVE":2.88,
    "SMILES":"[O-][N+](C1)=C2C(N1O)C(N(O)C(C)(C)C2)(C)C",
    "HIT":0.0,
    "question":"Can exposure to [O-][N+](C1)=C2C(N1O)C(N(O)C(C)(C)C2)(C)C lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":45229
  },
  {
    "COADD_ID":"CO-ADD:0289341",
    "INHIB_AVE":14.28,
    "SMILES":"n1c(COCc2ccccc2)onc1C(CCCN3)C3.Cl",
    "HIT":0.0,
    "question":"Does treatment with n1c(COCc2ccccc2)onc1C(CCCN3)C3.Cl result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":8602
  },
  {
    "COADD_ID":"CO-ADD:0329206",
    "INHIB_AVE":6.69,
    "SMILES":"S(=O)(=O)(c1cccc(cccc2)c12)N(CC3)CCN3c4ccc(c(Cl)c4)C",
    "HIT":0.0,
    "question":"Does treatment with S(=O)(=O)(c1cccc(cccc2)c12)N(CC3)CCN3c4ccc(c(Cl)c4)C result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":28324
  },
  {
    "COADD_ID":"CO-ADD:0292450",
    "INHIB_AVE":-18.04,
    "SMILES":"C1(c2ccccc2)(N3)C(c4ccccc4)(N=C(S\\C(\\C5=O)=C(\\c6c(N7C)cccc6)\/C7=O)N35)N(C(=O)N1C)C",
    "HIT":0.0,
    "question":"Does C1(c2ccccc2)(N3)C(c4ccccc4)(N=C(S\\C(\\C5=O)=C(\\c6c(N7C)cccc6)\/C7=O)N35)N(C(=O)N1C)C demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":81916
  },
  {
    "COADD_ID":"CO-ADD:0240494",
    "INHIB_AVE":1.48,
    "SMILES":"N1(CCN(CC2)CCO2)C(=S)SC(C)(C)C1N(O)C(=O)Nc3cccc(Cl)c3",
    "HIT":0.0,
    "question":"Can exposure to N1(CCN(CC2)CCO2)C(=S)SC(C)(C)C1N(O)C(=O)Nc3cccc(Cl)c3 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":51371
  },
  {
    "COADD_ID":"CO-ADD:0161194",
    "INHIB_AVE":11.48,
    "SMILES":"S(c1ccccc1)(=O)(=O)N\\N=C\\c2ccccc2[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Does S(c1ccccc1)(=O)(=O)N\\N=C\\c2ccccc2[N+](=O)[O-] demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":13496
  },
  {
    "COADD_ID":"CO-ADD:0283504",
    "INHIB_AVE":7.26,
    "SMILES":"N1(C2c3c(OC)ccc(cccc4)c34)C(S\\C(=C\\c(cc(n5c6ccc(cc6)Br)C)c5C)\\C1=O)=NC(c7ccccc7)=C2C(OCC)=O",
    "HIT":0.0,
    "question":"Can N1(C2c3c(OC)ccc(cccc4)c34)C(S\\C(=C\\c(cc(n5c6ccc(cc6)Br)C)c5C)\\C1=O)=NC(c7ccccc7)=C2C(OCC)=O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":26004
  },
  {
    "COADD_ID":"CO-ADD:0318792",
    "INHIB_AVE":-1.05,
    "SMILES":"c1(NC(=O)c(cc2)cc(c2[N+](=O)[O-])C)sc(c(C)c1C(OC)=O)C",
    "HIT":0.0,
    "question":"Can c1(NC(=O)c(cc2)cc(c2[N+](=O)[O-])C)sc(c(C)c1C(OC)=O)C effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":61262
  },
  {
    "COADD_ID":"CO-ADD:0286283",
    "INHIB_AVE":14.16,
    "SMILES":"C1(c(cccc2)c2C3(c4ccccc4C)c5ccccc5C)(S3)N(c6ccc(cc6)C)N=C(C(OCC)=O)S1",
    "HIT":0.0,
    "question":"Does C1(c(cccc2)c2C3(c4ccccc4C)c5ccccc5C)(S3)N(c6ccc(cc6)C)N=C(C(OCC)=O)S1 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":8782
  },
  {
    "COADD_ID":"CO-ADD:0222917",
    "INHIB_AVE":1.31,
    "SMILES":"[N+](=O)([O-])c(cc1)ccc1c(cc2)ccc2NC(=O)c3cccc(Br)c3",
    "HIT":0.0,
    "question":"Does [N+](=O)([O-])c(cc1)ccc1c(cc2)ccc2NC(=O)c3cccc(Br)c3 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":52113
  },
  {
    "COADD_ID":"CO-ADD:0288673",
    "INHIB_AVE":1.83,
    "SMILES":"C(=O)(OC(C)(C)C)N(CCC1c(n(Cc2ccco2)c(c3)C)n3)CC1",
    "HIT":0.0,
    "question":"Does C(=O)(OC(C)(C)C)N(CCC1c(n(Cc2ccco2)c(c3)C)n3)CC1 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":49874
  },
  {
    "COADD_ID":"CO-ADD:0320108",
    "INHIB_AVE":-6.72,
    "SMILES":"n(c1ccccc1)(c2C)nc(c2C(O)=O)C",
    "HIT":0.0,
    "question":"Is n(c1ccccc1)(c2C)nc(c2C(O)=O)C effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":74927
  },
  {
    "COADD_ID":"CO-ADD:0288691",
    "INHIB_AVE":5.56,
    "SMILES":"n(C(C)C)(c(cn1)C)c1CCNC(=O)OC(C)(C)C",
    "HIT":0.0,
    "question":"Can exposure to n(C(C)C)(c(cn1)C)c1CCNC(=O)OC(C)(C)C lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":33147
  },
  {
    "COADD_ID":"CO-ADD:0292153",
    "INHIB_AVE":-6.08,
    "SMILES":"C(=C\/C(=O)c1ccc(cc1)C)(\/Nc2c(N3)cccc2)\\C3=O",
    "HIT":0.0,
    "question":"Can C(=C\/C(=O)c1ccc(cc1)C)(\/Nc2c(N3)cccc2)\\C3=O effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":73887
  },
  {
    "COADD_ID":"CO-ADD:0155909",
    "INHIB_AVE":3.62,
    "SMILES":"N#CC1(C#N)C(N)=C(C2=CCN(C(C)C)C[C@]2([H])[C@H]1C3=CC=CC=C3Cl)C#N",
    "HIT":0.0,
    "question":"Can N#CC1(C#N)C(N)=C(C2=CCN(C(C)C)C[C@]2([H])[C@H]1C3=CC=CC=C3Cl)C#N act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":41856
  },
  {
    "COADD_ID":"CO-ADD:0254874",
    "INHIB_AVE":2.61,
    "SMILES":"n1(c2c(n3)cccc2)c3S\\C(=C\/c(ccc(c4OC)OC)c4)\\C1=O",
    "HIT":0.0,
    "question":"Can exposure to n1(c2c(n3)cccc2)c3S\\C(=C\/c(ccc(c4OC)OC)c4)\\C1=O lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":46379
  },
  {
    "COADD_ID":"CO-ADD:0295171",
    "INHIB_AVE":2.42,
    "SMILES":"c1(SC(C)C(=O)c2ccc(cc2)OC)[nH]c(c3n1)cc(c(C)c3)C",
    "HIT":0.0,
    "question":"Does treatment with c1(SC(C)C(=O)c2ccc(cc2)OC)[nH]c(c3n1)cc(c(C)c3)C result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":47200
  },
  {
    "COADD_ID":"CO-ADD:0217748",
    "INHIB_AVE":6.19,
    "SMILES":"n(c1F)c(N)c(c(F)n1)Br",
    "HIT":0.0,
    "question":"Does the proposed molecule n(c1F)c(N)c(c(F)n1)Br exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":30460
  },
  {
    "COADD_ID":"CO-ADD:0222610",
    "INHIB_AVE":11.65,
    "SMILES":"S(=O)(=O)(c(cc1)ccc1c2csc(Nc3cccc(cccc4)c34)n2)N5CCCCC5.Br",
    "HIT":0.0,
    "question":"Can S(=O)(=O)(c(cc1)ccc1c2csc(Nc3cccc(cccc4)c34)n2)N5CCCCC5.Br effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":13160
  },
  {
    "COADD_ID":"CO-ADD:0332014",
    "INHIB_AVE":-1.77,
    "SMILES":"C(=O)(c1ccc(c(OC)c1)OC)N(CC2)CCN2c3ccc(c(C)c3)C",
    "HIT":0.0,
    "question":"Can C(=O)(c1ccc(c(OC)c1)OC)N(CC2)CCN2c3ccc(c(C)c3)C act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":63638
  },
  {
    "COADD_ID":"CO-ADD:0258763",
    "INHIB_AVE":-9.36,
    "SMILES":"C(=O)(N\\N=C\\c1ccco1)C(=O)N2CCCCCC2",
    "HIT":0.0,
    "question":"Can exposure to C(=O)(N\\N=C\\c1ccco1)C(=O)N2CCCCCC2 lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":78203
  },
  {
    "COADD_ID":"CO-ADD:0288752",
    "INHIB_AVE":7.38,
    "SMILES":"c1(n(c(nc1)C(C2)CN2C(c3oc([N+](=O)[O-])cc3)=O)CCC)C",
    "HIT":0.0,
    "question":"Can exposure to c1(n(c(nc1)C(C2)CN2C(c3oc([N+](=O)[O-])cc3)=O)CCC)C lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":25564
  },
  {
    "COADD_ID":"CO-ADD:0283757",
    "INHIB_AVE":16.62,
    "SMILES":"n1(CC)c2c(nc1c3ccco3)c4c(cccc4)c(cccc5)c25",
    "HIT":0.0,
    "question":"Does n1(CC)c2c(nc1c3ccco3)c4c(cccc4)c(cccc5)c25 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":5681
  },
  {
    "COADD_ID":"CO-ADD:0230035",
    "INHIB_AVE":10.69,
    "SMILES":"N(CCO)(CCN(CCOCCN1CCO)CCO)CC1",
    "HIT":0.0,
    "question":"Is N(CCO)(CCN(CCOCCN1CCO)CCO)CC1 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":15249
  },
  {
    "COADD_ID":"CO-ADD:0320230",
    "INHIB_AVE":9.15,
    "SMILES":"c1(ccc(\\C=C\\C(=O)OCC(=O)c2cc(C)ccc2C)o1)[N+](=O)[O-].c3(ccc(\\C=C\\C(=O)OCC(=O)c4ccc(cc4C)C)o3)[N+](=O)[O-]",
    "HIT":0.0,
    "question":"Is c1(ccc(\\C=C\\C(=O)OCC(=O)c2cc(C)ccc2C)o1)[N+](=O)[O-].c3(ccc(\\C=C\\C(=O)OCC(=O)c4ccc(cc4C)C)o3)[N+](=O)[O-] capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":19456
  },
  {
    "COADD_ID":"CO-ADD:0215409",
    "INHIB_AVE":18.24,
    "SMILES":"C1(C#N)(C#N)C(N)=C(C#N)C(C2C13c4c(NC3=O)cccc4)=CCCC2",
    "HIT":0.0,
    "question":"Does the proposed molecule C1(C#N)(C#N)C(N)=C(C#N)C(C2C13c4c(NC3=O)cccc4)=CCCC2 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":4108
  },
  {
    "COADD_ID":"CO-ADD:0155412",
    "INHIB_AVE":13.7,
    "SMILES":"ClC1=CC=C(C=C1)C2=CSC(NC3=C(C)C=CC(C)=C3)=N2",
    "HIT":0.0,
    "question":"Is ClC1=CC=C(C=C1)C2=CSC(NC3=C(C)C=CC(C)=C3)=N2 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":9475
  },
  {
    "COADD_ID":"CO-ADD:0215465",
    "INHIB_AVE":10.49,
    "SMILES":"[N+](=O)([O-])c1cc(ccc1OC(=O)c2ccc(cc2)OC)\\C=N\\c(cc3)ccc3Br",
    "HIT":0.0,
    "question":"Does [N+](=O)([O-])c1cc(ccc1OC(=O)c2ccc(cc2)OC)\\C=N\\c(cc3)ccc3Br demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":15770
  },
  {
    "COADD_ID":"CO-ADD:0286907",
    "INHIB_AVE":9.44,
    "SMILES":"c12c(nnc(SCC(=O)Nc3nnc(SCC)s3)n1)c(c4n2C)cc(cc4)Br",
    "HIT":0.0,
    "question":"Does c12c(nnc(SCC(=O)Nc3nnc(SCC)s3)n1)c(c4n2C)cc(cc4)Br show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":18633
  },
  {
    "COADD_ID":"CO-ADD:0278274",
    "INHIB_AVE":0.76,
    "SMILES":"c1(SCc2ccc(cc2C)C)sc3c(ccc(c3)\\N=C\\c(cc4)ccc4I)n1",
    "HIT":0.0,
    "question":"Does the proposed molecule c1(SCc2ccc(cc2C)C)sc3c(ccc(c3)\\N=C\\c(cc4)ccc4I)n1 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":54459
  },
  {
    "COADD_ID":"CO-ADD:0235531",
    "INHIB_AVE":1.35,
    "SMILES":"C1(=C(CC(C)(C)CC1=O)OC(=C23)CC(CC2=O)(C)C)C3c4cc(Br)ccc4OC",
    "HIT":0.0,
    "question":"Does C1(=C(CC(C)(C)CC1=O)OC(=C23)CC(CC2=O)(C)C)C3c4cc(Br)ccc4OC demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":51966
  },
  {
    "COADD_ID":"CO-ADD:0287546",
    "INHIB_AVE":-2.89,
    "SMILES":"N12C(N=C(N)c(c3c(CCCCC3)s4)c14)=C(C(c5ccc(cc5)OCC)C6=C2CC(C)(C)CC6=O)C#N",
    "HIT":0.0,
    "question":"Does N12C(N=C(N)c(c3c(CCCCC3)s4)c14)=C(C(c5ccc(cc5)OCC)C6=C2CC(C)(C)CC6=O)C#N show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":66950
  },
  {
    "COADD_ID":"CO-ADD:0318772",
    "INHIB_AVE":4.37,
    "SMILES":"S(=O)(=O)(Nc(cc1)ccc1C(OCCCC)=O)c2ccc(c3c2)cccc3",
    "HIT":0.0,
    "question":"Does treatment with S(=O)(=O)(Nc(cc1)ccc1C(OCCCC)=O)c2ccc(c3c2)cccc3 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":38502
  },
  {
    "COADD_ID":"CO-ADD:0154863",
    "INHIB_AVE":7.01,
    "SMILES":"BrC1=CC(Br)=CC(\/C=N\/C2=CC=C(C=C2)C3=NC4=NC=CC=C4O3)=C1O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound BrC1=CC(Br)=CC(\/C=N\/C2=CC=C(C=C2)C3=NC4=NC=CC=C4O3)=C1O?",
    "answer":"No",
    "_id":26934
  },
  {
    "COADD_ID":"CO-ADD:0161576",
    "INHIB_AVE":13.83,
    "SMILES":"c1(\\C=N\\NC(COc(cc2)ccc2I)=O)c3c(cccc3)cc(cccc4)c14",
    "HIT":0.0,
    "question":"Does the proposed molecule c1(\\C=N\\NC(COc(cc2)ccc2I)=O)c3c(cccc3)cc(cccc4)c14 exhibit antibacterial activity against Escherichia coli?",
    "answer":"No",
    "_id":9286
  },
  {
    "COADD_ID":"CO-ADD:0137225",
    "INHIB_AVE":15.68,
    "SMILES":"c1(OC)cc(CCN(C[C@H](CC)[C@@]([H])(C[C@@](NC2)(c([nH]c(ccc(O)c3)c34)c4C2)[H])C5)[C@@]56[H])c6cc1OC",
    "HIT":0.0,
    "question":"Does c1(OC)cc(CCN(C[C@H](CC)[C@@]([H])(C[C@@](NC2)(c([nH]c(ccc(O)c3)c34)c4C2)[H])C5)[C@@]56[H])c6cc1OC demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":6732
  },
  {
    "COADD_ID":"CO-ADD:0219272",
    "INHIB_AVE":-0.56,
    "SMILES":"c1(c2cc(Br)ccc2O)[nH]c(c(c3ccccc3)n1)c4ccccc4",
    "HIT":0.0,
    "question":"Is c1(c2cc(Br)ccc2O)[nH]c(c(c3ccccc3)n1)c4ccccc4 effective in eliminating E. coli under experimental conditions?",
    "answer":"No",
    "_id":59571
  },
  {
    "COADD_ID":"CO-ADD:0219498",
    "INHIB_AVE":0.61,
    "SMILES":"c1(c(C)ccc(Cl)c1)\\N=C\\C=C(\/O)\\c2ccc(cc2)OC",
    "HIT":0.0,
    "question":"Can exposure to c1(c(C)ccc(Cl)c1)\\N=C\\C=C(\/O)\\c2ccc(cc2)OC lead to reduced viability of E. coli?",
    "answer":"No",
    "_id":55046
  },
  {
    "COADD_ID":"CO-ADD:0235054",
    "INHIB_AVE":-5.63,
    "SMILES":"c1(oc(c2n1)ccc(c2)\\N=C\\c(cc(Br)cc3[N+](=O)[O-])c3O)c4c(O)cc(c5c4)cccc5",
    "HIT":0.0,
    "question":"Is c1(oc(c2n1)ccc(c2)\\N=C\\c(cc(Br)cc3[N+](=O)[O-])c3O)c4c(O)cc(c5c4)cccc5 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":73057
  },
  {
    "COADD_ID":"CO-ADD:0327323",
    "INHIB_AVE":11.96,
    "SMILES":"c1(SC(N2C)=S)c2ncnc1N(CC3)CCN3C",
    "HIT":0.0,
    "question":"Does c1(SC(N2C)=S)c2ncnc1N(CC3)CCN3C show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":12508
  },
  {
    "COADD_ID":"CO-ADD:0283993",
    "INHIB_AVE":-3.97,
    "SMILES":"C(C(=O)OC(C)C)(=C(C)NC(=C12)CC(CC1=O)c3ccc(cc3)Cl)C2c(cc4OC)cc(c4O)Br",
    "HIT":0.0,
    "question":"Can C(C(=O)OC(C)C)(=C(C)NC(=C12)CC(CC1=O)c3ccc(cc3)Cl)C2c(cc4OC)cc(c4O)Br act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":69675
  },
  {
    "COADD_ID":"CO-ADD:0221634",
    "INHIB_AVE":-7.12,
    "SMILES":"[N+](=O)([O-])c1c(NCCCN)ccc(Cl)c1.Cl",
    "HIT":0.0,
    "question":"Does [N+](=O)([O-])c1c(NCCCN)ccc(Cl)c1.Cl demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":75513
  },
  {
    "COADD_ID":"CO-ADD:0232935",
    "INHIB_AVE":-7.26,
    "SMILES":"c1(C#N)c2c(sc1\\N=C\\c(scc3[N+](=O)[O-])c3)CC(C)CC2",
    "HIT":0.0,
    "question":"Does treatment with c1(C#N)c2c(sc1\\N=C\\c(scc3[N+](=O)[O-])c3)CC(C)CC2 result in bacteriostatic or bactericidal effects on E. coli?",
    "answer":"No",
    "_id":75714
  },
  {
    "COADD_ID":"CO-ADD:0253011",
    "INHIB_AVE":8.77,
    "SMILES":"N1(C(=O)c2cccc(OC)c2)C(O)(c3ccc(cc3)CC)CC(C(F)(F)F)=N1",
    "HIT":0.0,
    "question":"Can N1(C(=O)c2cccc(OC)c2)C(O)(c3ccc(cc3)CC)CC(C(F)(F)F)=N1 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":20623
  },
  {
    "COADD_ID":"CO-ADD:0222384",
    "INHIB_AVE":0.46,
    "SMILES":"n1c2c(oc1c3cccc(c3)\\N=C\\c(ccc(c4[N+](=O)[O-])Cl)c4)ccc(C)c2",
    "HIT":0.0,
    "question":"Does n1c2c(oc1c3cccc(c3)\\N=C\\c(ccc(c4[N+](=O)[O-])Cl)c4)ccc(C)c2 demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":55658
  },
  {
    "COADD_ID":"CO-ADD:0328925",
    "INHIB_AVE":-1.83,
    "SMILES":"N1(NC(C)=O)C2(CCCC2)Nc(c3C1=O)cccc3",
    "HIT":0.0,
    "question":"Can N1(NC(C)=O)C2(CCCC2)Nc(c3C1=O)cccc3 effectively kill or suppress Escherichia coli cells?",
    "answer":"No",
    "_id":63832
  },
  {
    "COADD_ID":"CO-ADD:0229799",
    "INHIB_AVE":1.44,
    "SMILES":"c(C(OCC)=O)(s1)c(NC(C)=O)c2c1\\C(=N\/O)\\C(CC2)Sc3ccccc3",
    "HIT":0.0,
    "question":"Is c(C(OCC)=O)(s1)c(NC(C)=O)c2c1\\C(=N\/O)\\C(CC2)Sc3ccccc3 capable of inhibiting the growth or survival of E. coli?",
    "answer":"No",
    "_id":51532
  },
  {
    "COADD_ID":"CO-ADD:0286630",
    "INHIB_AVE":-0.11,
    "SMILES":"N(C(c1ccccc1)=O)(C(C)(C)C(N2CC3(C)CC3(Cl)Cl)=O)C2=O",
    "HIT":0.0,
    "question":"Is Escherichia coli susceptible to treatment with the compound N(C(c1ccccc1)=O)(C(C)(C)C(N2CC3(C)CC3(Cl)Cl)=O)C2=O?",
    "answer":"No",
    "_id":57924
  },
  {
    "COADD_ID":"CO-ADD:0230412",
    "INHIB_AVE":-8.06,
    "SMILES":"C1(=C(O)CC(C)(C)CC1=O)C(C2C(=O)CC(CC2=O)(C)C)c3ccc(C)o3",
    "HIT":0.0,
    "question":"Does C1(=C(O)CC(C)(C)CC1=O)C(C2C(=O)CC(CC2=O)(C)C)c3ccc(C)o3 show antimicrobial efficacy specifically against Escherichia coli strains?",
    "answer":"No",
    "_id":76792
  },
  {
    "COADD_ID":"CO-ADD:0242294",
    "INHIB_AVE":1.52,
    "SMILES":"c1([nH]c(c2n1)cccc2)\\C(\\C#N)=C\\c(cc(Br)cc3[N+](=O)[O-])c3O",
    "HIT":0.0,
    "question":"Can c1([nH]c(c2n1)cccc2)\\C(\\C#N)=C\\c(cc(Br)cc3[N+](=O)[O-])c3O act as an antibacterial agent targeting Escherichia coli?",
    "answer":"No",
    "_id":51191
  },
  {
    "COADD_ID":"CO-ADD:0327326",
    "INHIB_AVE":15.58,
    "SMILES":"N1(c2ccccc2)N=C(C(C(C)C)C1=S)O",
    "HIT":0.0,
    "question":"Does N1(c2ccccc2)N=C(C(C(C)C)C1=S)O demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":6840
  },
  {
    "COADD_ID":"CO-ADD:0229284",
    "INHIB_AVE":16.24,
    "SMILES":"C1(C(OCC)=O)=C(C)NC(NC1c2c(ccc(cccc3)c23)OCC(OCC)=O)=S",
    "HIT":0.0,
    "question":"Does C1(C(OCC)=O)=C(C)NC(NC1c2c(ccc(cccc3)c23)OCC(OCC)=O)=S demonstrate bactericidal effects against E. coli in vitro?",
    "answer":"No",
    "_id":6070
  }
]