{ "model_name": "hierarchical_gmm_30_types_300_subtypes", "release_tag": "2026_W42", "data_vintage": "2026_W41", "architecture": { "modalities": [ "waveform", "acg", "stpc" ], "modality_latent_dim": 20, "joint_latent_dim": 60, "density": "hierarchical Gaussian mixture, full covariances", "n_types": 30, "n_subtypes": 300, "max_subtypes_per_type": 10, "min_units_per_subtype": 20, "assignment": "top-down: P(k, j | z) = P(k | z) P(j | k, z), P(j | k, z) among the sub-types of k", "context_conditioning": "sub-type weights gamma_k(x) gamma_j|k(x), from two context networks", "context_definition": "50 MERFISH PCs + 50 AGEA PCs", "phenotype_readout": "members: each sub-type's TRAIN units from anywhere in the brain, weighted by their top-down posterior of the sub-type" }, "split_counts": { "train_units": 56497, "validation_units": 7671, "test_units": 15880, "train_pids": 572, "validation_pids": 75, "test_pids": 149 }, "heldout_basic_test": { "model": "hierarchical_gmm_30_types_300_subtypes", "split": "held-out test PIDs", "reconstruction": { "waveform_mse": 0.000788584933616221, "acg_mse": 4.7604778956156224e-05, "stpc_mse": 0.006178959738463163, "n_test_units": 4096 }, "latent_nll": { "context_weights": -29.065819952667763, "brain_wide_weights": -28.336594620975855, "context_improvement": 0.7292253316919073, "n_test_units": 15880, "lower_is_better": true }, "sanity_checks": { "all_metrics_finite": true, "context_beats_brain_wide": true, "subtypes_inside_types": true } }, "invariants": [ "TEST PIDs are never used for AE/mixture/context training or as readout members.", "The type and sub-type means and covariance matrices are global.", "Molecular context changes only the sub-type weights gamma_k(x) gamma_j|k(x).", "A unit's sub-type always lies inside its type (top-down assignment).", "All spatial modeling uses the configured single-hemisphere mirroring convention." ] }