| """ |
| Ground truth data from KMP 2x2x2 factorial transcriptomic study. |
| |
| This module contains the experimental data from the Kaempferol (KMP) countermeasure |
| study examining: |
| - 4 tissues: Heart, Hippocampus, Liver, Soleus |
| - 2 stressors: Hindlimb Unloading (HU), Ionizing Radiation (IR) |
| - 1 intervention: Kaempferol (KMP) |
| """ |
|
|
| from typing import Dict, Any |
|
|
| |
| STRESSOR_EFFECTS: Dict[str, Dict[str, int]] = { |
| "Heart": {"HU": 165, "IR": 33, "HU_IR": 910}, |
| "Hippocampus": {"HU": 1555, "IR": 5477, "HU_IR": 5510}, |
| "Liver": {"HU": 4110, "IR": 1273, "HU_IR": 6213}, |
| "Soleus": {"HU": 6425, "IR": 67, "HU_IR": 6830}, |
| } |
|
|
| |
| KMP_EFFECTS: Dict[str, Dict[str, int]] = { |
| "Heart": {"baseline": 112, "in_HU": 2, "in_IR": 2, "in_HU_IR": 2110}, |
| "Hippocampus": {"baseline": 4110, "in_HU": 1, "in_IR": 243, "in_HU_IR": 140}, |
| "Liver": {"baseline": 309, "in_HU": 17, "in_IR": 389, "in_HU_IR": 3}, |
| "Soleus": {"baseline": 0, "in_HU": 1, "in_IR": 52, "in_HU_IR": 491}, |
| } |
|
|
| |
| INTERACTIONS: Dict[str, Dict[str, int]] = { |
| "Heart": {"HU_x_IR": 244, "KMP_x_HU": 479, "KMP_x_IR": 29}, |
| "Hippocampus": {"HU_x_IR": 93, "KMP_x_HU": 36, "KMP_x_IR": 1221}, |
| "Liver": {"HU_x_IR": 3210, "KMP_x_HU": 3369, "KMP_x_IR": 247}, |
| "Soleus": {"HU_x_IR": 211, "KMP_x_HU": 8484, "KMP_x_IR": 484}, |
| } |
|
|
| |
| TISSUE_TYPES: Dict[str, str] = { |
| "Heart": "Type A (stress-activated)", |
| "Soleus": "Type A (stress-activated)", |
| "Hippocampus": "Type B (baseline-active)", |
| "Liver": "Type C (stress-blocked)", |
| } |
|
|
| |
| OXPHOS_PATTERNS: Dict[str, Dict[str, Any]] = { |
| "Heart": {"stress_NES": -2.302, "KMP_NES": 3.691, "pattern": "RESCUE"}, |
| "Hippocampus": {"stress_NES": 0.931, "KMP_NES": 1.585, "pattern": "KMP Only"}, |
| "Liver": {"stress_NES": 3.596, "KMP_NES": -1.6, "pattern": "SUPPRESSION"}, |
| "Soleus": {"stress_NES": -2.997, "KMP_NES": 2.46, "pattern": "RESCUE"}, |
| } |
|
|
