README.md

---
license: mit
library_name: pytorch
tags:
- protein-sequence-generation
- flow-matching
- bioinformatics
- protein-language-models
- pfam
---

# LineageFlow RP55 Checkpoint

This repository hosts the released LineageFlow checkpoint for family-aware protein sequence generation.

## Files

- `lineageflow-rp55.ckpt`: LineageFlow denoiser checkpoint.
- `SHA256SUMS`: checksum for verifying the checkpoint download.

## Usage

```bash
hf download jinxbye/LineageFlow \
  lineageflow-rp55.ckpt \
  --local-dir checkpoints
```

See the GitHub repository for inference and evaluation code:

```text
https://github.com/jinxbye/LineageFlow
```

## Citation

```bibtex
@inproceedings{liang2026lineageflow,
  title     = {LineageFlow: Flow Matching for High-Fidelity Family-Aware Protein Sequence Generation},
  author    = {Liang, Langzhang and Yang, Ming and Feng, Yi and Li, Junfan and Pan, Shirui and Xu, Yinghui and Ying, Tianlei and Zheng, Yizhen and Xu, Zenglin},
  booktitle = {International Conference on Machine Learning},
  year      = {2026}
}
```