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  - biology
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  - single-cell
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  - scFM
 
 
 
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  ---
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- <img src="lemur-flaticon.png" alt="Lemur icon" width="150">
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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  - biology
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  - single-cell
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  - scFM
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+ - Drosophila
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+ - foundation-model
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+ - cell-type-annotation
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  ---
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+ <div align="start">
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+ <img src="lemur-flaticon.png" alt="Lemur Icon" width="250">
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+ <h1>Lemur: A Single-Cell Foundation Model for <em>Drosophila melanogaster</em> 🪰🔬</h1>
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+ </div>
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+ **Lemur** is a single-cell foundation model developed specifically for *Drosophila melanogaster*. It achieves fine-tuning-free cell-type annotation using two key innovations:
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+ - **Comprehensive Pre-training:** Trained on an integrated whole-organism atlas with a unified cell-type annotation schema.
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+ - **Hierarchical Decoding:** Employs a transformer-based hierarchical cell-type decoder to generate consistent predictions at multiple levels of granularity.
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+
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+ ### Highlights
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+ - **Fine-Tuning-Free Annotation:** No extra training required on new datasets.
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+ - **Robust Across Conditions:** Consistent performance across various tissue types, experimental conditions, and sequencing platforms.
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+ - **Zero-Shot Batch-Effect Correction:** Automatically corrects batch effects without further adjustments.
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+ - **Broad Applications:** Tailored for the fly research community with potential implications for aging and neurodegenerative disease studies in humans.
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+
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+ ### Status & Availability
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+ - **Model Weights:** Available now on the Hugging Face Hub.
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+ - **Code:** Will be made public alongside our preprint 📄.
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+ Happy modeling! 🚀