SVSTR-Score / tier_thresholds.json
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Release v1.0: HPRC-trained 35/21-feature calibrated SV+STR models (#1)
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{
"release_version": "1.0",
"tiers": {
"HIGH": "CS>=0.70",
"MODERATE": "0.50<=CS<0.70",
"WARNING": "0.30<=CS<0.50",
"LOW": "CS<0.30"
},
"score": "CS = isotonic-calibrated probability of concordance with long-read truth",
"calibration": "isotonic on OOF; SV Brier 0.0771->0.0744, STR 0.1673->0.1589",
"note": "Tiers are buckets of the calibrated CS. HIGH is the candidate-triage tier."
}