{
  "within.lasso": {
    "auroc": 0.9503968253968255,
    "auprc": 0.9537083978980874,
    "brier": 0.09780938831091726,
    "sensitivity_at_spec90": 0.873015873015873,
    "specificity_at_sens90": 0.8548387096774194,
    "n": 250,
    "prevalence": 0.504,
    "auroc_ci95": [
      0.9246015745007681,
      0.9740303379416283
    ]
  },
  "within.gbm": {
    "auroc": 0.8972094214029698,
    "auprc": 0.9088239565472542,
    "brier": 0.14035917875148912,
    "sensitivity_at_spec90": 0.7142857142857143,
    "specificity_at_sens90": 0.6290322580645161,
    "n": 250,
    "prevalence": 0.504,
    "auroc_ci95": [
      0.8586741551459294,
      0.9322244623655914
    ]
  },
  "within.targeted": {
    "auroc": 0.9139784946236559,
    "auprc": 0.9239706329613951,
    "brier": 0.12130136959989281,
    "sensitivity_at_spec90": 0.753968253968254,
    "specificity_at_sens90": 0.6854838709677419,
    "n": 250,
    "prevalence": 0.504,
    "auroc_ci95": [
      0.8787090373783922,
      0.9436795954941117
    ]
  },
  "within.multimodal": {
    "auroc": 0.9567332309267793,
    "auprc": 0.9589696832413457,
    "brier": 0.09072201619977514,
    "sensitivity_at_spec90": 0.8888888888888888,
    "specificity_at_sens90": 0.8870967741935484,
    "n": 250,
    "prevalence": 0.504,
    "auroc_ci95": [
      0.933173323092678,
      0.9761952764976959
    ]
  },
  "within.clinical_only": {
    "auroc": 0.6690988223246288,
    "auprc": 0.6859693850230023,
    "brier": 0.22678546064067975,
    "sensitivity_at_spec90": 0.2698412698412698,
    "specificity_at_sens90": 0.18548387096774194,
    "n": 250,
    "prevalence": 0.504
  },
  "external.lasso": {
    "auroc": 0.9423728813559322,
    "auprc": 0.738482943780696,
    "brier": 0.4649400820862006,
    "sensitivity_at_spec90": 0.8,
    "specificity_at_sens90": 0.864406779661017,
    "n": 192,
    "prevalence": 0.078125,
    "auroc_ci95": [
      0.8805743879472693,
      0.9864406779661017
    ]
  },
  "external.gbm": {
    "auroc": 0.9212806026365348,
    "auprc": 0.5820216624108571,
    "brier": 0.28547947784607763,
    "sensitivity_at_spec90": 0.8666666666666667,
    "specificity_at_sens90": 0.6666666666666666,
    "n": 192,
    "prevalence": 0.078125,
    "auroc_ci95": [
      0.8418079096045198,
      0.9834274952919021
    ]
  },
  "selected_panel": [
    {
      "probe": "cg_ZNF345_2",
      "gene": "ZNF345",
      "coef": 0.7035181247656423
    },
    {
      "probe": "cg_TFPI2_1",
      "gene": "TFPI2",
      "coef": 0.5380634042743031
    },
    {
      "probe": "cg_VIM_1",
      "gene": "VIM",
      "coef": 0.478083363737724
    },
    {
      "probe": "cg_CCNA1_3",
      "gene": "CCNA1",
      "coef": 0.4403272227367819
    },
    {
      "probe": "cg_TAC1_1",
      "gene": "TAC1",
      "coef": 0.4207556722110058
    },
    {
      "probe": "cg_VIM_2",
      "gene": "VIM",
      "coef": 0.3264920743253056
    },
    {
      "probe": "cg_TFPI2_2",
      "gene": "TFPI2",
      "coef": 0.3120380728741678
    },
    {
      "probe": "cg_NELL1_1",
      "gene": "NELL1",
      "coef": 0.3008969535191267
    },
    {
      "probe": "cg_VIM_3",
      "gene": "VIM",
      "coef": 0.27840107854419205
    },
    {
      "probe": "cg_CCNA1_2",
      "gene": "CCNA1",
      "coef": 0.18589863770343062
    },
    {
      "probe": "bg_01511",
      "gene": "background",
      "coef": -0.15830800052901345
    },
    {
      "probe": "cg_ZNF345_1",
      "gene": "ZNF345",
      "coef": 0.14178484941506977
    },
    {
      "probe": "bg_01691",
      "gene": "background",
      "coef": 0.13350253242783736
    },
    {
      "probe": "bg_01367",
      "gene": "background",
      "coef": 0.12902553267595554
    },
    {
      "probe": "bg_01532",
      "gene": "background",
      "coef": -0.12201077014600044
    },
    {
      "probe": "bg_00290",
      "gene": "background",
      "coef": -0.1101334005361793
    },
    {
      "probe": "bg_00733",
      "gene": "background",
      "coef": 0.10831257522986705
    },
    {
      "probe": "bg_00105",
      "gene": "background",
      "coef": -0.10737308224671371
    },
    {
      "probe": "bg_00509",
      "gene": "background",
      "coef": 0.10623849312332573
    },
    {
      "probe": "bg_00686",
      "gene": "background",
      "coef": -0.09256552909242247
    },
    {
      "probe": "bg_00994",
      "gene": "background",
      "coef": 0.08975507656339371
    },
    {
      "probe": "bg_01544",
      "gene": "background",
      "coef": -0.0880138674460795
    },
    {
      "probe": "bg_00140",
      "gene": "background",
      "coef": 0.08341806735469658
    },
    {
      "probe": "bg_00641",
      "gene": "background",
      "coef": -0.08049141437016215
    },
    {
      "probe": "bg_00080",
      "gene": "background",
      "coef": -0.07966493645195764
    }
  ],
  "gbm_top_features": [
    {
      "probe": "cg_ZNF345_2",
      "gene": "ZNF345",
      "importance": 0.44761625569077046
    },
    {
      "probe": "cg_CCNA1_3",
      "gene": "CCNA1",
      "importance": 0.3919606170447708
    },
    {
      "probe": "cg_TFPI2_1",
      "gene": "TFPI2",
      "importance": 0.33921190341330115
    },
    {
      "probe": "cg_VIM_1",
      "gene": "VIM",
      "importance": 0.2951477251550466
    },
    {
      "probe": "cg_TAC1_1",
      "gene": "TAC1",
      "importance": 0.2890054574210354
    },
    {
      "probe": "cg_TFPI2_2",
      "gene": "TFPI2",
      "importance": 0.25664946466597705
    },
    {
      "probe": "cg_VIM_3",
      "gene": "VIM",
      "importance": 0.1199790025149959
    },
    {
      "probe": "cg_NELL1_1",
      "gene": "NELL1",
      "importance": 0.11122904068379584
    },
    {
      "probe": "cg_CCNA1_2",
      "gene": "CCNA1",
      "importance": 0.11077148485183563
    },
    {
      "probe": "cg_CCNA1_1",
      "gene": "CCNA1",
      "importance": 0.10342810589743917
    },
    {
      "probe": "cg_SST_1",
      "gene": "SST",
      "importance": 0.09712306979141481
    },
    {
      "probe": "bg_00924",
      "gene": "background",
      "importance": 0.09479481971948106
    },
    {
      "probe": "cg_VIM_2",
      "gene": "VIM",
      "importance": 0.09407314074850304
    },
    {
      "probe": "bg_00771",
      "gene": "background",
      "importance": 0.08693690495060578
    },
    {
      "probe": "cg_ZNF345_1",
      "gene": "ZNF345",
      "importance": 0.08437516401768441
    },
    {
      "probe": "bg_01581",
      "gene": "background",
      "importance": 0.07109450882190814
    },
    {
      "probe": "bg_00944",
      "gene": "background",
      "importance": 0.039676060837992425
    },
    {
      "probe": "bg_00757",
      "gene": "background",
      "importance": 0.03689797391343528
    },
    {
      "probe": "bg_01281",
      "gene": "background",
      "importance": 0.034912264438296474
    },
    {
      "probe": "bg_00720",
      "gene": "background",
      "importance": 0.0338130151909994
    }
  ],
  "_summary": {
    "discovery_cohort": "GSE81334_like",
    "external_cohort": "GSE104707_like",
    "n_discovery": 250,
    "n_external": 192,
    "n_probes_after_qc": 2074,
    "n_samples_dropped_qc": 18,
    "discovery_prevalence": 0.504,
    "external_prevalence": 0.078125
  }
}