{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.6, "construct": {"method_text_verbatim": "There are at least one of several drawbacks to the above described classical formulation approach. Firstly, classification of fragrance materials by their characters is subjective and therefore results in inconsistency in the fragrance profile under classical fragrance pyramid construction rules. Secondly, the perceived intensity of the fragrance profile of the conventional perfume compositions, particularly those characters attributable to the more volatile fragrance materials, decreases rapidly over time due to their quick evaporation. Accordingly, conventional perfume compositions will typically change their overall fragrance profile over time. This is a problem because it is desirable to maintain \"fragrance profile fidelity\" over time. In other words, it is desirable to maintain the same or substantively similar fragrance profile for a commercial fragrance over time, particularly over long periods of time (at least 4 hrs, 6 hrs, or even 8 hours after application). Thirdly, with the", "panel_size": null, "property_name": "fragrance_intensity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["4 hrs", "6 hrs", "8 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "4 hrs; 6 hrs; 8 hours", "patent_id": "EP3141239B1", "provenance": {"citation": "EP3141239B1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3141239B1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:5", "units": "hours", "verbatim_quote": "There are at least one of several drawbacks to the above described classical formulation approach. Firstly, classification of fragrance materials by their characters is subjective and therefore results in inconsistency in the fragrance profile under classical fragrance pyramid construction rules. Secondly, the perceived intensity of the fragrance profile of the conventional perfume compositions, particularly those characters attributable to the more volatile fragrance materials, decreases rapidly over time due to their quick evaporation. Accordingly, conventional perfume compositions will typically change their overall fragrance profile over time. This is a problem because it is desirable to maintain \"fragrance profile fidelity\" over time. In other words, it is desirable to maintain the same or substantively similar fragrance profile for a commercial fragrance over time, particularly over long periods of time (at least 4 hrs, 6 hrs, or even 8 hours after application). Thirdly, with the classical fragrance pyramid construction, the possible types of fragrance profiles have been somewhat limited. The consequence of using base notes at high levels is that many fragrance dry-downs appear repetitive, boring, non-memorable and uninteresting to consumers. However, if base notes are reduced or excluded then the fragrance intensity weakens over time and does not last for a sufficient duration. Lastly, it is generally accepted that some consumers desire prolonged intensity of select characters, particularly the floral, spicy or aromatic characters derived from the heart notes. Unfortunately, the consequence of using high levels of base notes is that they may impart particularly undesirable characters, such as for example, musky, woody, ambery, warm and sweet, which overpower and dominate the more desirable fragrance characters over time, particular over long periods of time. Thus, the unique challenge remains of selectively extending the more desirable characters attributable from the heart and/or top notes, particularly the heart notes, and even more particularly extending these desirable characters over long periods of time."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.6, "construct": {"method_text_verbatim": "Thus, it is an advantage of the present invention to provide new rules for objectively classifying fragrance materials according to their volatility using their their vapor pressures defined at suitable temperature, instead of their characters. The new rules operate irrespective of perfumers performing the classification. In particular, the new rules classify the fragrance materials into low, moderate or high volatile fragrance materials for formulating into fragrance mixtures, particularly ones having a diamond construction. It is a further advantage of the present invention to provide compositions having improved fidelity to the perceived fragrance profile over time. It is yet a further advantage to provide a composition, wherein the character attributable to moderate and high volatile fragrance materials, particularly the moderate volatile fragrance materials, remains significantly consistent from its initial impression to the end. It is yet a further advantage to provide compositio", "panel_size": null, "property_name": "longevity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["8 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "8 hours", "patent_id": "EP3141239B1", "provenance": {"citation": "EP3141239B1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3141239B1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:66", "units": "hours", "verbatim_quote": "Thus, it is an advantage of the present invention to provide new rules for objectively classifying fragrance materials according to their volatility using their their vapor pressures defined at suitable temperature, instead of their characters. The new rules operate irrespective of perfumers performing the classification. In particular, the new rules classify the fragrance materials into low, moderate or high volatile fragrance materials for formulating into fragrance mixtures, particularly ones having a diamond construction. It is a further advantage of the present invention to provide compositions having improved fidelity to the perceived fragrance profile over time. It is yet a further advantage to provide a composition, wherein the character attributable to moderate and high volatile fragrance materials, particularly the moderate volatile fragrance materials, remains significantly consistent from its initial impression to the end. It is yet a further advantage to provide compositions having improved longevity of the perceived fragrance profile, preferably the characters attributable from the moderate or high volatile fragrance materials, particularly the moderate volatile fragrance material. It is yet a further advantage to provide compositions having stable quality of end product (e.g., fragrance profile, visual appearance) substantially comparable to the classical fragrance pyramid three-tiered structure, preferably even after three months storage at 40 \u00b0C. It is yet a further advantage to be able to create new to the world fragrance profiles wherein one, or several, well-recognized moderate volatile fragrance material characters, are maintained over time, preferably for long periods of time ( e . g ., greater than 4, 6, or even 8 hours)."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.85, "construct": {"method_text_verbatim": "The present invention provides a method for imparting, intensifying, or modifying an odour on human skin or human hair, comprising applying to human skin and/or human hair the composition of the present invention. It is preferred that the method is for imparting, intensifying or modifying the longevity of a floral character or aromatic/spicy character on human skin or human hair, wherein the perceived intensity of the floral character or aromatic/spicy character at 1 hr, 2 hrs, 3 hrs or 6 hrs after application is greater than a control composition that does not include the substantially non-odorous fragrance modulator as determined by the panel method as disclosed herein.", "panel_size": null, "property_name": "longevity", "scale": "hours_or_timepoint", "substrate": ["hair", "skin"], "time_points": ["1 hr", "2 hrs", "3 hrs", "6 hrs"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "1 hr; 2 hrs; 3 hrs; 6 hrs", "patent_id": "EP3141239B1", "provenance": {"citation": "EP3141239B1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3141239B1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:158", "units": "hours", "verbatim_quote": "The present invention provides a method for imparting, intensifying, or modifying an odour on human skin or human hair, comprising applying to human skin and/or human hair the composition of the present invention. It is preferred that the method is for imparting, intensifying or modifying the longevity of a floral character or aromatic/spicy character on human skin or human hair, wherein the perceived intensity of the floral character or aromatic/spicy character at 1 hr, 2 hrs, 3 hrs or 6 hrs after application is greater than a control composition that does not include the substantially non-odorous fragrance modulator as determined by the panel method as disclosed herein."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.7, "construct": {"method_text_verbatim": "At the testing facility, 50 \u00b5L samples of the compositions and the controls are applied to glass slides and placed on a hot plate at 32 \u00b0C to represent skin temperature for varying durations. It is important that glass slides of samples that are to be later compared are prepared at the same time. The panelists are asked to evaluate the perceived fragrance profile (intensity and/or character) of each glass slide sample at a given time point. Slides are presented coded so that their identity is not known by the panelists. Within a given time point panelists evaluate the slides in a random order and are able to revisit their assessment as they work through the slides at that time point. Their assessments are recorded. In the subsequent analysis, the data for strength and character comparisons are drawn from the independent assessments carried out at a given time point. Only when using the character difference scale below are any 2 products physically directly compared to each other. Panel", "panel_size": null, "property_name": "duration", "scale": "numeric_unknown", "substrate": ["skin"], "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "6-10", "patent_id": "EP3141239B1", "provenance": {"citation": "EP3141239B1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3141239B1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:975", "units": null, "verbatim_quote": "At the testing facility, 50 \u00b5L samples of the compositions and the controls are applied to glass slides and placed on a hot plate at 32 \u00b0C to represent skin temperature for varying durations. It is important that glass slides of samples that are to be later compared are prepared at the same time. The panelists are asked to evaluate the perceived fragrance profile (intensity and/or character) of each glass slide sample at a given time point. Slides are presented coded so that their identity is not known by the panelists. Within a given time point panelists evaluate the slides in a random order and are able to revisit their assessment as they work through the slides at that time point. Their assessments are recorded. In the subsequent analysis, the data for strength and character comparisons are drawn from the independent assessments carried out at a given time point. Only when using the character difference scale below are any 2 products physically directly compared to each other. Panelists are selected from individuals who are either trained to evaluate fragrances according to the scales below or who have experience of fragrance evaluation in the industry. Typically, around 6-10 panellists are used to evaluate a given product and its control."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.55, "construct": {"method_text_verbatim": "The panelists are asked to give a score on a scale of 0 to 5 for perceived fragrance intensity according to the odour intensity scale set out in Table 4 herein below. Table 4 - Odour Intensity Scale Score Fragrance Intensity 0 None 1 Very Weak 2 Weak 3 Moderate 4 Strong 5 Very Strong", "panel_size": null, "property_name": "fragrance_intensity", "scale": "numeric_unknown", "substrate": null, "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "0 to 5", "patent_id": "EP3141239B1", "provenance": {"citation": "EP3141239B1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3141239B1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:976", "units": null, "verbatim_quote": "The panelists are asked to give a score on a scale of 0 to 5 for perceived fragrance intensity according to the odour intensity scale set out in Table 4 herein below. Table 4 - Odour Intensity Scale Score Fragrance Intensity 0 None 1 Very Weak 2 Weak 3 Moderate 4 Strong 5 Very Strong"}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": "Example 6", "confidence": 0.75, "construct": {"method_text_verbatim": "The following test is carried out to demonstrate the improved or enhanced longevity of a fragrance profile of a composition of the present invention vs. a control. In particular, the test measures the effect of a substantially non-odorous fragrance fixative on the evaporation rate of one or more fragrance materials (e.g., 10 PRMs) formulated in a composition. The evaporation response of the fragrance materials to the fixative, as a function of time, is measured through the use of gas chromatography (\"GC\"). 1. A test composition may comprise a substantially non-odorous fragrance fixative (any one of the fixatives as disclosed in Tables 4(a) and 4(b)) with either: (i) a fragrance material (any one of the moderate volatile fragrance materials as disclosed in Table 2 and high volatile fragrance materials as disclosed in Table 3), or (ii) a blend of fragrance materials from Tables 2 and 3 (as disclosed as Fragrance Example 6 in Table 11). The test compositions also contain high purity ethan", "panel_size": null, "property_name": "longevity", "scale": "percent", "substrate": null, "time_points": ["1 hr", "2 hrs", "3 hrs", "4 hrs", "5 hrs", "6 hrs", "8 hrs", "12 hrs"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "100%; 90 to 95; 99 to 99.75; 1 hr; 2 hrs; 3 hrs; 4 hrs; 5 hrs; 6 hrs; 8 hrs; 12 hrs; 5 to 10; 25 to 40", "patent_id": "EP3141239B1", "provenance": {"citation": "EP3141239B1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3141239B1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:997", "units": "hours", "verbatim_quote": "The following test is carried out to demonstrate the improved or enhanced longevity of a fragrance profile of a composition of the present invention vs. a control. In particular, the test measures the effect of a substantially non-odorous fragrance fixative on the evaporation rate of one or more fragrance materials (e.g., 10 PRMs) formulated in a composition. The evaporation response of the fragrance materials to the fixative, as a function of time, is measured through the use of gas chromatography (\"GC\"). 1. A test composition may comprise a substantially non-odorous fragrance fixative (any one of the fixatives as disclosed in Tables 4(a) and 4(b)) with either: (i) a fragrance material (any one of the moderate volatile fragrance materials as disclosed in Table 2 and high volatile fragrance materials as disclosed in Table 3), or (ii) a blend of fragrance materials from Tables 2 and 3 (as disclosed as Fragrance Example 6 in Table 11). The test compositions also contain high purity ethanol, such as Hayman 100%EP/BP grade, and deionized water. Samples test compositions are provided in Tables 19(a)-19(b). All of the ingredients are admixed until evenly distributed in the test compositions. 2. A control composition to the test composition described in 1 above, without the substantially non-odorous fragrance fixative is made in a similar manner to Step 1, except that the missing substantially non-odorous fixative is replaced by deionized water. Sample control compositions are provided in Tables 19(a)-19(b). 3. An internal standard is needed to correct for variations of the amount of composition dispensed in the evaporation test as well as loss during the GC analysis. The internal standard has a vapor pressure of less than 0.001 Torr (0.000133 kPa) at 25 \u00b0C and is soluble in the composition and fragrance material. A suitable non-limiting example of an internal standard is triethyl citrate. The internal standard and fragrance material are admixed until evenly distributed at a level of 90 to 95 parts by weight of fragrance material and the required amount of internal standard to reach 100 parts. This mixture is then use to prepare the sample compositions in Step 1 and 2. Alternatively, the internal standard and test or control composition are admixed until evenly distributed at a level of 99 to 99.75 parts by weight of composition and the required amount of internal standard to reach 100 parts. This resultant solution is used in subsequent steps. 4. A hotplate is set to a temperature of 32 \u00b0C. An aluminum container, such as TA Instruments T-Zero \u2122 pan, is placed on the hotplate. 20 \u00b5L of the test or control composition is introduced in the aluminum container using a micropipette. Alternatively, the aluminum container may be filled with the test or control composition to its full capacity. The time at which this takes place is determined to be time zero ( i.e., T = 0). Multiple aluminum containers are prepared and left at the set temperature for pre-determined periods of time, such as for example 30 mins, 1 hr, 2 hrs, 3 hrs, 4 hrs, 5 hrs, 6 hrs, 8 hrs and up to 12 hrs. 5. The aluminum container is removed from the hotplate at the end of the pre-determined time period and transferred by being inserted into a 4 mL glass vial already containing at least 2 mL of highly volatile solvent, such as high purity ethanol or hexane. 6. The glass vial is mixed using a Heidolph multi REAX shaker, or equivalent, for 5 to 10 mins to extract the fragrance materials into the solvent phase. 1.5 mL of the resultant solution is transferred to a 2 mL GC vial. 7. The GC vial is analysed on an Agilent GC system 6890 equipped with an autosampler, or equivalent. A GC column such as a DB-5MS, Rxi-5 SilMS model or equivalent phase, with a length of 30 m, an inner diameter of 0.25 mm and a film thickness of 1 \u00b5m is used. The GC parameters are set to the values indicated as follows: Table 5(iii) - GC Parameters Injector temperature: 270 \u00b0C Initial gas velocity: 25 to 40 cm/sec (for Helium as the carrier gas) Initial oven temperature: 50 \u00b0C Temperature ramp: 8 \u00b0C/min Final oven temperature: 310 \u00b0C Gas chromatography with flame ionization detection (\"FID\") or with mass spectrometry (\"MS\") can be used for the identification and quantification of fragrance material in the compositions. Either detection system can be used in conjunction with GC. The column dimensions as well as GC settings described in this method, such as injector temperature, carrier gas velocity, temperature ramp and final oven temperature can be adjusted to optimize the response of the fragrance material and internal standard being monitored. The detection system settings, such as FID gas flows and temperature or MS parameters, should be optimized by a trained analyst to enable the precise detection and quantification of the analytes of interest. 8. The peak area of the fragrance material and internal standard are recorded. The peak area ratio of the fragrance material and the internal standard is calculated at each time point for each sample composition. The % of non-evaporated fragrance material remaining from T = 0 is calculated at each time point for each sample composition. The % fragrance material remaining in each composition is plotted to give an evaporation profile over time. This is done for both the test and control compositions. Significance is determined by comparison of the evaporation profile for the same fragrance material or same fragrance mixture in the test and control compositions."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": "example 10", "confidence": 0.9, "construct": {"method_text_verbatim": "The following test is carried out to demonstrate the character retention over time of a fragrance composition of the present invention vs. a control. It is necessary for the test and control samples to be run at approximately the same time to ensure that ambient conditions are the same. The test measures the presence of one or more fragrance materials in the headspace formed in a sealed vial by the test composition, after set evaporation times. The fragrance profile in the headspace is measured at specific time points through the use of headspace (\"HS\") gas chromatography (\"GC\"). 1. The test and control compositions as described in the Example section are used for the evaluation. 2. Capillaries of about 2 cm to 3.5 cm, with one sealed end are cut from a Sigma Aldrich \"Stuart \u2122 melting point tube\" product code Z673269, or equivalent. A suitable fixed volume chosen between 50 and 200 \u00b5L of the composition is pipetted into the well of a VWR Tissue Culture 96 F well plate, or equivalent. T", "panel_size": null, "property_name": "headspace_concentration_or_intensity", "scale": "hours_or_timepoint", "substrate": ["headspace"], "time_points": ["1 hr", "2 hrs", "3 hrs", "4 hrs", "5 hrs", "6 hrs"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "1 hr; 2 hrs; 3 hrs; 4 hrs; 5 hrs; 6 hrs; 50/30; 20 to 40", "patent_id": "EP3141239B1", "provenance": {"citation": "EP3141239B1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3141239B1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:1003", "units": "hours", "verbatim_quote": "The following test is carried out to demonstrate the character retention over time of a fragrance composition of the present invention vs. a control. It is necessary for the test and control samples to be run at approximately the same time to ensure that ambient conditions are the same. The test measures the presence of one or more fragrance materials in the headspace formed in a sealed vial by the test composition, after set evaporation times. The fragrance profile in the headspace is measured at specific time points through the use of headspace (\"HS\") gas chromatography (\"GC\"). 1. The test and control compositions as described in the Example section are used for the evaluation. 2. Capillaries of about 2 cm to 3.5 cm, with one sealed end are cut from a Sigma Aldrich \"Stuart \u2122 melting point tube\" product code Z673269, or equivalent. A suitable fixed volume chosen between 50 and 200 \u00b5L of the composition is pipetted into the well of a VWR Tissue Culture 96 F well plate, or equivalent. The sealed end of the glass capillary is dipped into the filled well and left for at least 15 secs to wet the surface of the glass. Care must be taken not to contact the glass capillary with the sides of the well by maintaining it straight and approximately in the center of the well. 3. The glass capillary is then removed from the well and inverted or transferred onto a stable surface or into a holder and allowed to evaporate at ambient conditions for a set period of time. A windshield may be used to reduce high air turbulence. 4. The glass capillary is then introduced into an empty 20 mL HS vial, which is immediately closed with a PTFE cap. The time at which this takes place is determined to be time T = initial ( i.e., T = 10 mins). 5. Multiple glass capillaries are prepared in the same way and left to evaporate at ambient temperature for pre-determined periods of time, such as for example 10, 15, 30 mins, 1 hr, 2 hrs, 3 hrs, 4 hrs, 5 hrs, and up to 6 hrs, before being introduced to the headspace vial and sealed. 6. The HS vial is then analysed on an Agilent GC system 6890 equipped with a Gerstel MPS 2 autosampler, or equivalent, capable of performing SPME injections. A SPME fiber assembly DVB/CAR/PDMS (50/30 \u00b5m, 1 cm length) is required. A GC column such as a DB-5MS, ZB-5MSi models, or equivalent phase, with a length of 30 m, an inner diameter of 0.25 mm and a film thickness of 1 \u00b5m is used. 7. The SPME HS parameters are set to the values indicated as follows: Table 5(iv) - SPME Parameters Incubation chamber temperature: 40 \u00b0C Incubation time: 20 mins Agitation of sample 250 RPM Extraction time 5 mins Desorption time 2 mins 8. The GC parameters are set to the values indicated as follows: Table 5(v) - GC Parameters Injector temperature: 270 \u00b0C Initial gas velocity: 20 to 40 cm/sec (for Helium as the carrier gas) Initial oven temperature: 45\u00b0C with 2 mins Hold Time Temperature ramp 1: 30 \u00b0C/min Temperature 1: 80 \u00b0C Temperature ramp 2: 8 \u00b0C/min Final temperature: 300 \u00b0C Gas chromatography with flame ionization detection (\"FID\") or with mass spectrometry (\"MS\") can be used for the identification and quantification of fragrance material in the compositions. Either detection system can be used in conjunction with GC. The column dimensions as well as GC settings described in this method, such as injector temperature, carrier gas velocity, temperature ramp and final oven temperature can be adjusted to optimize the response of the fragrance material being monitored. The detection system settings, such as FID gas flows and temperature or MS parameters, should be optimized by a trained analyst to enable the precise detection and identification of the analytes of interest. 9. A qualitative assessment of the chromatograms obtained is performed by comparing the peak height of the fragrance materials and overall chromatogram at time T = 10 mins to other time points. A dotted line is drawn around an estimated retention time where fragrance materials with a vapour pressure of 0.001 Torr or less (0.000133 kPa or less) elute during the analysis. The difference between the peaks present at each measured time point for the test and control compositions provides evidence of the retention of the character of the fragrance over time. 10. This test set-up is designed to enable the collection of the headspace in a manner that does not saturate the SPME fiber. If the fiber is saturated it does not provide an accurate analysis of the headspace composition. Therefore the quantity of liquid and the evaporation surface area are very different from those in the olfactive evaluation of the same samples. For this reason it is not possible to compare directly the evaporation time frames used in the 2 experiments. It is expected that the evaporation profile is much faster in this headspace experiments compared to the olfactive evaluations."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.7, "construct": {"method_text_verbatim": "Compositions disclosed in Tables 18(a)-18(d), 20, 21, and 22(a)-22(d) are applied to glass slides in accordance with the protocol described in the Method Section and a panel of 6-10 experienced panelists evaluate the perceived fragrance profile at initial time 0, then at various time points, typically 1 hour, 2 hours, 3 hours, 4 hours and 6 hours post application. Panelists are asked to score the compositions for the longevity and/or fidelity of the fragrance profile on a scale of 0 to 5, wherein 0 represents a no fragrance is detected and 5 represents a very strong fragrance intensity is detected. The results of the panelists are then averaged and discussed below.", "panel_size": null, "property_name": "fragrance_intensity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["1 hour", "2 hours", "3 hours", "4 hours", "6 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "6-10; 1 hour; 2 hours; 3 hours; 4 hours; 6 hours; 0 to 5", "patent_id": "EP3141239B1", "provenance": {"citation": "EP3141239B1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3141239B1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:1472", "units": "hours", "verbatim_quote": "Compositions disclosed in Tables 18(a)-18(d), 20, 21, and 22(a)-22(d) are applied to glass slides in accordance with the protocol described in the Method Section and a panel of 6-10 experienced panelists evaluate the perceived fragrance profile at initial time 0, then at various time points, typically 1 hour, 2 hours, 3 hours, 4 hours and 6 hours post application. Panelists are asked to score the compositions for the longevity and/or fidelity of the fragrance profile on a scale of 0 to 5, wherein 0 represents a no fragrance is detected and 5 represents a very strong fragrance intensity is detected. The results of the panelists are then averaged and discussed below."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.7, "construct": {"method_text_verbatim": "Figure 2 shows the fragrance intensity profile of Composition A9 (as disclosed in Table 22(c)) as evaluated by 10 panelists, which comprises the substantially non-odorous fragrance fixative Bis-methoxy PEG-13 PEG-438/PPG-110 SMDI Copolymer ( i.e ., Expert Gel \u00ae 56) and the single fragrance material Indocolore. Addition of the substantially non-odorous fragrance fixative (Expert Gel \u00ae 56) maintains the intensity of the fragrance material for up to at least 6 hours whilst the control, Composition B9, in the absence of the substantially non-odorous fragrance fixative, drops in fragrance intensity profile much more over this time. The substantially non-odorous fragrance fixative acts to maintain the continued initial evaporation over time of the fragrance material. Statistical analysis using the Tukey correction for multiple comparisons confirms the statistically significant difference at 1, 3 and 6 hours (p < 0.0001) at 95% significance level ( i.e. , p < 0.05) at all these time points.", "panel_size": 10, "property_name": "fragrance_intensity", "scale": "percent", "substrate": null, "time_points": ["6 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "6 hours", "patent_id": "EP3141239B1", "provenance": {"citation": "EP3141239B1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3141239B1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:1473", "units": "hours", "verbatim_quote": "Figure 2 shows the fragrance intensity profile of Composition A9 (as disclosed in Table 22(c)) as evaluated by 10 panelists, which comprises the substantially non-odorous fragrance fixative Bis-methoxy PEG-13 PEG-438/PPG-110 SMDI Copolymer ( i.e ., Expert Gel \u00ae 56) and the single fragrance material Indocolore. Addition of the substantially non-odorous fragrance fixative (Expert Gel \u00ae 56) maintains the intensity of the fragrance material for up to at least 6 hours whilst the control, Composition B9, in the absence of the substantially non-odorous fragrance fixative, drops in fragrance intensity profile much more over this time. The substantially non-odorous fragrance fixative acts to maintain the continued initial evaporation over time of the fragrance material. Statistical analysis using the Tukey correction for multiple comparisons confirms the statistically significant difference at 1, 3 and 6 hours (p < 0.0001) at 95% significance level ( i.e. , p < 0.05) at all these time points."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.7, "construct": {"method_text_verbatim": "Figure 3 shows the fragrance intensity profile of Composition C9 (as disclosed in Table 22(c)) as evaluated by 9 panelists, which comprises the substantially non-odorous fragrance fixative propyl {4-[2-(diethylamino)-2-oxoethoxy]-3-methoxyphenyl}acetate ( i.e., Kolliphor \u00ae EL) and the single fragrance material Dimethyl Benzyl Carbinol. Addition of the substantially non-odorous fragrance fixative (Kolliphor \u00ae EL) maintains the intensity of the fragrance material for up to at least 6 hours whilst the control, Composition D9, in the absence of the substantially non-odorous fragrance fixative, drops in fragrance intensity profile much more over this time. The substantially non-odorous fragrance fixative acts to maintain the reduced rate of evaporation over time of the fragrance material. Statistical analysis using the Tukey correction for multiple comparisons confirms the statistically significant difference at 1 hour (p < 0.0001), 3 hours (p = 0.0265) and 6 hours (p = 0.0388) at 95% signi", "panel_size": 9, "property_name": "fragrance_intensity", "scale": "percent", "substrate": null, "time_points": ["6 hours", "1 hour", "3 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "6 hours; 1 hour; 3 hours", "patent_id": "EP3141239B1", "provenance": {"citation": "EP3141239B1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3141239B1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:1474", "units": "hours", "verbatim_quote": "Figure 3 shows the fragrance intensity profile of Composition C9 (as disclosed in Table 22(c)) as evaluated by 9 panelists, which comprises the substantially non-odorous fragrance fixative propyl {4-[2-(diethylamino)-2-oxoethoxy]-3-methoxyphenyl}acetate ( i.e., Kolliphor \u00ae EL) and the single fragrance material Dimethyl Benzyl Carbinol. Addition of the substantially non-odorous fragrance fixative (Kolliphor \u00ae EL) maintains the intensity of the fragrance material for up to at least 6 hours whilst the control, Composition D9, in the absence of the substantially non-odorous fragrance fixative, drops in fragrance intensity profile much more over this time. The substantially non-odorous fragrance fixative acts to maintain the reduced rate of evaporation over time of the fragrance material. Statistical analysis using the Tukey correction for multiple comparisons confirms the statistically significant difference at 1 hour (p < 0.0001), 3 hours (p = 0.0265) and 6 hours (p = 0.0388) at 95% significance level ( i.e., p < 0.05) at all these time points."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.7, "construct": {"method_text_verbatim": "Figure 4 shows the fragrance intensity profile of Composition E9 (as disclosed in Table 22(c)) as evaluated by 9 panelists, which comprises the substantially non-odorous fragrance fixative propyl {4-[2-(diethylamino)-2-oxoethoxy]-3-methoxyphenyl}acetate ( i.e., Kolliphor \u00ae EL) and the single fragrance material Eugenol. Addition of the substantially non-odorous fragrance fixative (Kolliphor \u00ae EL) maintains the intensity of the fragrance material for up to at least 6 hours whilst the control, Composition F9, in the absence of the substantially non-odorous fragrance fixative, drops in fragrance intensity profile much more over this time. The substantially non-odorous fragrance fixative acts to supress the initial display of Eugenol and then maintains that continued initial evaporation over time. Statistical analysis using the Tukey correction for multiple comparisons confirms the statistically significant difference at 0 hours (p = 0.0025), 1 hour (p < 0.0001), 3 hours (p < 0.0001) and 6 ", "panel_size": 9, "property_name": "fragrance_intensity", "scale": "percent", "substrate": null, "time_points": ["6 hours", "0 hours", "1 hour", "3 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "6 hours; 0 hours; 1 hour; 3 hours", "patent_id": "EP3141239B1", "provenance": {"citation": "EP3141239B1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3141239B1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:1475", "units": "hours", "verbatim_quote": "Figure 4 shows the fragrance intensity profile of Composition E9 (as disclosed in Table 22(c)) as evaluated by 9 panelists, which comprises the substantially non-odorous fragrance fixative propyl {4-[2-(diethylamino)-2-oxoethoxy]-3-methoxyphenyl}acetate ( i.e., Kolliphor \u00ae EL) and the single fragrance material Eugenol. Addition of the substantially non-odorous fragrance fixative (Kolliphor \u00ae EL) maintains the intensity of the fragrance material for up to at least 6 hours whilst the control, Composition F9, in the absence of the substantially non-odorous fragrance fixative, drops in fragrance intensity profile much more over this time. The substantially non-odorous fragrance fixative acts to supress the initial display of Eugenol and then maintains that continued initial evaporation over time. Statistical analysis using the Tukey correction for multiple comparisons confirms the statistically significant difference at 0 hours (p = 0.0025), 1 hour (p < 0.0001), 3 hours (p < 0.0001) and 6 hours (p < 0.0001) at 95% significance level ( i.e., p < 0.05) at all time points."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.7, "construct": {"method_text_verbatim": "Figure 5 shows the fragrance intensity profile of Composition G9 (as disclosed in Table 22(c)) as evaluated by 9 panelists, which comprises the substantially non-odorous fragrance fixative propyl {4-[2-(diethylamino)-2-oxoethoxy]-3-methoxyphenyl}acetate ( i.e., Kolliphor \u00ae EL) and the single fragrance material Phenethyl alcohol (PEA). Addition of the substantially non-odorous fragrance fixative (Kolliphor \u00ae EL) maintains the intensity of the fragrance material from 1 hour to 3 hours whilst the control, Composition H9, in the absence of the substantially non-odorous fragrance fixative, drops in fragrance intensity profile over this time. The substantially non-odorous fragrance fixative acts to maintain the reduced rate of evaporation over time of the fragrance material. Statistical analysis using the Tukey correction for multiple comparisons confirms the statistically significant difference at 1 hour (p < 0.0001) at 95% significance level ( i.e., p < 0.05) and at 3 hours (p = 0.0876) at", "panel_size": 9, "property_name": "fragrance_intensity", "scale": "percent", "substrate": null, "time_points": ["1 hour", "3 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "1 hour; 3 hours", "patent_id": "EP3141239B1", "provenance": {"citation": "EP3141239B1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3141239B1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:1476", "units": "hours", "verbatim_quote": "Figure 5 shows the fragrance intensity profile of Composition G9 (as disclosed in Table 22(c)) as evaluated by 9 panelists, which comprises the substantially non-odorous fragrance fixative propyl {4-[2-(diethylamino)-2-oxoethoxy]-3-methoxyphenyl}acetate ( i.e., Kolliphor \u00ae EL) and the single fragrance material Phenethyl alcohol (PEA). Addition of the substantially non-odorous fragrance fixative (Kolliphor \u00ae EL) maintains the intensity of the fragrance material from 1 hour to 3 hours whilst the control, Composition H9, in the absence of the substantially non-odorous fragrance fixative, drops in fragrance intensity profile over this time. The substantially non-odorous fragrance fixative acts to maintain the reduced rate of evaporation over time of the fragrance material. Statistical analysis using the Tukey correction for multiple comparisons confirms the statistically significant difference at 1 hour (p < 0.0001) at 95% significance level ( i.e., p < 0.05) and at 3 hours (p = 0.0876) at 90% significance level ( i.e., p < 0.1)."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.7, "construct": {"method_text_verbatim": "Panelists are asked to score the compositions for the intensity of the fragrance on a scale of 0 to 5, wherein 0 represents a no fragrance intensity is detected and 5 represents a very strong fragrance intensity is detected. The results of the panel test are then averaged. The results show the effect of the substantially non-odorous fragrance fixative and diamond constructed fragrance materials for any one of the inventive Compositions A1, A2, A3, A4, A5, D1, D2, D4, G1, G2, G4, J1, J2, J4, M1, and M2 on fragrance profile longevity versus control Compositions C1, C2, C3, C4, C5, F1, F2, F4, I1, I2, I4, L1, L2, L4, O1, and O2 in the absence of the substantially non-odorous fixative. Alternatively, the results show the effect of the substantially non-odorous fragrance fixative and diamond constructed fragrance materials for any one of the inventive Compositions A1, A2, A3, A4, A5, D1, D2, D4, G1, G2, G4, J1, J2, J4, M1, and M2 on fragrance profile longevity versus traditional Composition", "panel_size": null, "property_name": "fragrance_intensity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["6 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "0 to 5; 6 hours", "patent_id": "EP3141239B1", "provenance": {"citation": "EP3141239B1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3141239B1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:1477", "units": "hours", "verbatim_quote": "Panelists are asked to score the compositions for the intensity of the fragrance on a scale of 0 to 5, wherein 0 represents a no fragrance intensity is detected and 5 represents a very strong fragrance intensity is detected. The results of the panel test are then averaged. The results show the effect of the substantially non-odorous fragrance fixative and diamond constructed fragrance materials for any one of the inventive Compositions A1, A2, A3, A4, A5, D1, D2, D4, G1, G2, G4, J1, J2, J4, M1, and M2 on fragrance profile longevity versus control Compositions C1, C2, C3, C4, C5, F1, F2, F4, I1, I2, I4, L1, L2, L4, O1, and O2 in the absence of the substantially non-odorous fixative. Alternatively, the results show the effect of the substantially non-odorous fragrance fixative and diamond constructed fragrance materials for any one of the inventive Compositions A1, A2, A3, A4, A5, D1, D2, D4, G1, G2, G4, J1, J2, J4, M1, and M2 on fragrance profile longevity versus traditional Compositions B1, B2, B3, B4, B5, E1, E2, E4, H1, H2, H4, K1, K2, K4, N1, and N2 in the presence of the substantially non-odorous fragrance fixative. Fragrance profile longevity, particularly intensity of the characters attributable to the volatile fragrance materials are maintained for up to at least 6 hours in the presence of the substantially non-odorous fragrance fixative whilst it drops in the absence of the substantially non-odorous fragrance fixative."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": "Example 4b", "confidence": 0.75, "construct": {"method_text_verbatim": "Figure 6 provides the fragrance intensity profile of Composition A4 (as disclosed in Table 18(d)), which comprises the substantially non-odorous fragrance fixative PPG-20 Methyl Glucose Ether ( i.e., Glucam \u2122 P-20) and the Diamond Floral Magnifica Fragrance Example 4b. Addition of the substantially non-odorous fragrance fixative Glucam \u2122 P-20 maintains the intensity of the fragrance material for up to 6 hours. As compared to the control Composition C4, in the absence of the substantially non-odorous fragrance fixative Glucam \u2122 P-20, and comprising the Traditional Floral Magnifica Fragrance Example 4a drops in fragrance intensity over the 6 hours.", "panel_size": null, "property_name": "fragrance_intensity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["6 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "6 hours", "patent_id": "EP3141239B1", "provenance": {"citation": "EP3141239B1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3141239B1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:1478", "units": "hours", "verbatim_quote": "Figure 6 provides the fragrance intensity profile of Composition A4 (as disclosed in Table 18(d)), which comprises the substantially non-odorous fragrance fixative PPG-20 Methyl Glucose Ether ( i.e., Glucam \u2122 P-20) and the Diamond Floral Magnifica Fragrance Example 4b. Addition of the substantially non-odorous fragrance fixative Glucam \u2122 P-20 maintains the intensity of the fragrance material for up to 6 hours. As compared to the control Composition C4, in the absence of the substantially non-odorous fragrance fixative Glucam \u2122 P-20, and comprising the Traditional Floral Magnifica Fragrance Example 4a drops in fragrance intensity over the 6 hours."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": "Example 5b", "confidence": 0.75, "construct": {"method_text_verbatim": "Figure 7 provides the fragrance intensity profile of Composition A4 (as disclosed in Table 18(d)), which comprises the substantially non-odorous fragrance fixative PPG-20 Methyl Glucose Ether ( i.e. , Glucam \u2122 P-20) and the Diamond Muguesia Magnifica Fragrance Example 5b. Addition of the substantially non-odorous fragrance fixative Glucam \u2122 P-20 maintains the intensity of the fragrance material for up to 6 hours. As compared to the control Composition C4, in the absence of the substantially non-odorous fragrance fixative Glucam \u2122 P-20, and comprising the Traditional Muguesia Magnifica Fragrance Example 5a drops in fragrance intensity over the 6 hours.", "panel_size": null, "property_name": "fragrance_intensity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["6 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "6 hours", "patent_id": "EP3141239B1", "provenance": {"citation": "EP3141239B1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3141239B1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:1479", "units": "hours", "verbatim_quote": "Figure 7 provides the fragrance intensity profile of Composition A4 (as disclosed in Table 18(d)), which comprises the substantially non-odorous fragrance fixative PPG-20 Methyl Glucose Ether ( i.e. , Glucam \u2122 P-20) and the Diamond Muguesia Magnifica Fragrance Example 5b. Addition of the substantially non-odorous fragrance fixative Glucam \u2122 P-20 maintains the intensity of the fragrance material for up to 6 hours. As compared to the control Composition C4, in the absence of the substantially non-odorous fragrance fixative Glucam \u2122 P-20, and comprising the Traditional Muguesia Magnifica Fragrance Example 5a drops in fragrance intensity over the 6 hours."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": "Example 4b", "confidence": 0.75, "construct": {"method_text_verbatim": "Figure 8 provides the fragrance intensity profile of Composition A2 (as disclosed in Table 18(b)), which comprises 15 wt% substantially non-odorous fragrance fixative Diisobutyl Adipate and 7 wt% Diamond Floral Magnifica Fragrance Example 4b. Addition of the substantially non-odorous fragrance fixative Diisobutyl Adipate maintains the intensity of the fragrance material for up to 6 hours. As compared to the control Composition C2, in the absence of the substantially non-odorous fragrance fixative Diisobutyl Adipate, and comprising 7 wt% Traditional Floral Magnifica Fragrance Example 4a drops in fragrance intensity over the 6 hours.", "panel_size": null, "property_name": "fragrance_intensity", "scale": "percent", "substrate": null, "time_points": ["6 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "6 hours", "patent_id": "EP3141239B1", "provenance": {"citation": "EP3141239B1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3141239B1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:1480", "units": "hours", "verbatim_quote": "Figure 8 provides the fragrance intensity profile of Composition A2 (as disclosed in Table 18(b)), which comprises 15 wt% substantially non-odorous fragrance fixative Diisobutyl Adipate and 7 wt% Diamond Floral Magnifica Fragrance Example 4b. Addition of the substantially non-odorous fragrance fixative Diisobutyl Adipate maintains the intensity of the fragrance material for up to 6 hours. As compared to the control Composition C2, in the absence of the substantially non-odorous fragrance fixative Diisobutyl Adipate, and comprising 7 wt% Traditional Floral Magnifica Fragrance Example 4a drops in fragrance intensity over the 6 hours."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": "Example 5b", "confidence": 0.75, "construct": {"method_text_verbatim": "Figure 9 provides the fragrance intensity profile of Composition A2 (as disclosed in Table 18(b)), which comprises 15 wt% substantially non-odorous fragrance fixative Diisobutyl Adipate and 7 wt% Diamond Muguesia Magnifica Fragrance Example 5b. Addition of the substantially non-odorous fragrance fixative Diisobutyl Adipate maintains the intensity of the fragrance material for up to 6 hours. As compared to the control Composition C2, in the absence of the substantially non-odorous fragrance fixative Diisobutyl Adipate, and comprising 7 wt% Traditional Muguesia Magnifica Fragrance Example 5a drops in fragrance intensity over the 6 hours.", "panel_size": null, "property_name": "fragrance_intensity", "scale": "percent", "substrate": null, "time_points": ["6 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "6 hours", "patent_id": "EP3141239B1", "provenance": {"citation": "EP3141239B1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3141239B1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:1481", "units": "hours", "verbatim_quote": "Figure 9 provides the fragrance intensity profile of Composition A2 (as disclosed in Table 18(b)), which comprises 15 wt% substantially non-odorous fragrance fixative Diisobutyl Adipate and 7 wt% Diamond Muguesia Magnifica Fragrance Example 5b. Addition of the substantially non-odorous fragrance fixative Diisobutyl Adipate maintains the intensity of the fragrance material for up to 6 hours. As compared to the control Composition C2, in the absence of the substantially non-odorous fragrance fixative Diisobutyl Adipate, and comprising 7 wt% Traditional Muguesia Magnifica Fragrance Example 5a drops in fragrance intensity over the 6 hours."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.6, "construct": {"method_text_verbatim": "Without wishing to be bound by theory, it is believed that the substantially non-odorous fragrance fixative acts to maintain the continued evaporation over time of the fragrance materials, particular the volatile fragrance materials. The effects of the improved fragrance profile longevity of the present invention are noticeable at, any one of, 1, 3 and 6 hours post application.", "panel_size": null, "property_name": "longevity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["6 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "6 hours", "patent_id": "EP3141239B1", "provenance": {"citation": "EP3141239B1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3141239B1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:1483", "units": "hours", "verbatim_quote": "Without wishing to be bound by theory, it is believed that the substantially non-odorous fragrance fixative acts to maintain the continued evaporation over time of the fragrance materials, particular the volatile fragrance materials. The effects of the improved fragrance profile longevity of the present invention are noticeable at, any one of, 1, 3 and 6 hours post application."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.6, "construct": {"method_text_verbatim": "The test demonstrates the character retention over time of a fragrance composition. The results show the effect of the substantially non-odorous fragrance fixative and fragrance materials in a diamond construction for any one of the inventive Compositions A1, A2, A3, A4, A5, D1, D2, D4, G1, G2, G4, J1, J2, J4, M1, and M2 on fragrance profile versus control Compositions C1, C2, C3, C4, C5, F1, F2, F4, I1, I2, I4, L1, L2, L4, O1, and O2 in the absence of the substantially non-odorous fragrance fixative. Alternatively, results show the effect of the substantially non-odorous fragrance fixative and fragrance materials in a diamond construction for any one of the inventive Compositions A1, A2, A3, A4, A5, D1, D2, D4, G1, G2, G4, J1, J2, J4, M1, and M2 on fragrance profile longevity versus traditional Compositions B1, B2, B3, B4, B5, E1, E2, E4, H1, H2, H4, K1, K2, K4, N1, and N2 in the presence of the substantially non-odorous fragrance fixative. Fragrance profile fidelity, particularly of ", "panel_size": null, "property_name": "longevity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["1 hour"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "1 hour", "patent_id": "EP3141239B1", "provenance": {"citation": "EP3141239B1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3141239B1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:1502", "units": "hours", "verbatim_quote": "The test demonstrates the character retention over time of a fragrance composition. The results show the effect of the substantially non-odorous fragrance fixative and fragrance materials in a diamond construction for any one of the inventive Compositions A1, A2, A3, A4, A5, D1, D2, D4, G1, G2, G4, J1, J2, J4, M1, and M2 on fragrance profile versus control Compositions C1, C2, C3, C4, C5, F1, F2, F4, I1, I2, I4, L1, L2, L4, O1, and O2 in the absence of the substantially non-odorous fragrance fixative. Alternatively, results show the effect of the substantially non-odorous fragrance fixative and fragrance materials in a diamond construction for any one of the inventive Compositions A1, A2, A3, A4, A5, D1, D2, D4, G1, G2, G4, J1, J2, J4, M1, and M2 on fragrance profile longevity versus traditional Compositions B1, B2, B3, B4, B5, E1, E2, E4, H1, H2, H4, K1, K2, K4, N1, and N2 in the presence of the substantially non-odorous fragrance fixative. Fragrance profile fidelity, particularly of floral characters attributable to the volatile fragrance materials are maintained for up to at least 1 hour in the presence of the substantially non-odorous fragrance fixative whilst it drops in the absence of the substantially non-odorous fragrance fixative."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.6, "construct": {"method_text_verbatim": "The composition according to any one of the preceding claims, wherein the composition maintains the perceived fragrance profile, particularly the characters attributable to the moderate volatile fragrance material and/or high volatile fragrance material, to remain substantively unchanged from application up to 2 hrs, 3 hrs, 4 hrs, 5 hrs, 6 hrs or 8 hrs after application vs. a control composition that does not include a diamond construction fragrance formulation and the substantially non-odorous fragrance fixative, as determined according to the Odour Test as described herein under Test Method 2: Olfactory Tests.", "panel_size": null, "property_name": "substantivity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["2 hrs", "3 hrs", "4 hrs", "5 hrs", "6 hrs", "8 hrs"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "2 hrs; 3 hrs; 4 hrs; 5 hrs; 6 hrs; 8 hrs", "patent_id": "EP3141239B1", "provenance": {"citation": "EP3141239B1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3141239B1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "claims:15", "units": "hours", "verbatim_quote": "The composition according to any one of the preceding claims, wherein the composition maintains the perceived fragrance profile, particularly the characters attributable to the moderate volatile fragrance material and/or high volatile fragrance material, to remain substantively unchanged from application up to 2 hrs, 3 hrs, 4 hrs, 5 hrs, 6 hrs or 8 hrs after application vs. a control composition that does not include a diamond construction fragrance formulation and the substantially non-odorous fragrance fixative, as determined according to the Odour Test as described herein under Test Method 2: Olfactory Tests."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.85, "construct": {"method_text_verbatim": "The method according to claim 19, wherein the method is for imparting, intensifying or modifying the longevity of a floral character on human skin or human hair, wherein the perceived intensity of the floral character at 1 hr, 2 hrs, 3 hrs or 6 hrs after application is greater than a control composition that does not include the substantially non-odorous fragrance fixative as determined by the panel method as disclosed herein under Test Method 2: Olfactory Tests, and wherein the floral character is selected from the group consisting of lavender-type note, a rose-type note, a lily of the valley-type note, a muguet-type note, a jasmine-type note, a magnolia-type note, a cyclamen-type note, a hyacinth-type note, a lilac-type note, an orange blossom-type note, a cherry blossom-type note, a peony-type note, a lotus-type note, a linden blossom-type note, an osmanthus-type note, a lilac-type note, a heliotrope-type note, a violet-type note, an orris-type note, a tiare-type note, and a patchou", "panel_size": null, "property_name": "longevity", "scale": "hours_or_timepoint", "substrate": ["hair", "skin"], "time_points": ["1 hr", "2 hrs", "3 hrs", "6 hrs"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "1 hr; 2 hrs; 3 hrs; 6 hrs", "patent_id": "EP3141239B1", "provenance": {"citation": "EP3141239B1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3141239B1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "claims:20", "units": "hours", "verbatim_quote": "The method according to claim 19, wherein the method is for imparting, intensifying or modifying the longevity of a floral character on human skin or human hair, wherein the perceived intensity of the floral character at 1 hr, 2 hrs, 3 hrs or 6 hrs after application is greater than a control composition that does not include the substantially non-odorous fragrance fixative as determined by the panel method as disclosed herein under Test Method 2: Olfactory Tests, and wherein the floral character is selected from the group consisting of lavender-type note, a rose-type note, a lily of the valley-type note, a muguet-type note, a jasmine-type note, a magnolia-type note, a cyclamen-type note, a hyacinth-type note, a lilac-type note, an orange blossom-type note, a cherry blossom-type note, a peony-type note, a lotus-type note, a linden blossom-type note, an osmanthus-type note, a lilac-type note, a heliotrope-type note, a violet-type note, an orris-type note, a tiare-type note, and a patchouli-type note."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": "example 10", "confidence": 0.9, "construct": {"method_text_verbatim": "1. The test and control compositions as described in the Example section are used for the evaluation. 2. Capillaries of about 2 cm to 3.5 cm, with one sealed end are cut from a Sigma Aldrich \u201cStuart\u2122 melting point tube\u201d product code Z673269, or equivalent. A suitable fixed volume chosen between 50 and 200 \u03bcL of the composition is pipetted into the well of a VWR Tissue Culture 96 F well plate, or equivalent. The sealed end of the glass capillary is dipped into the filled well and left for at least 15 secs to wet the surface of the glass. Care must be taken not to contact the glass capillary with the sides of the well by maintaining it straight and approximately in the center of the well. 3. The glass capillary is then removed from the well and inverted or transferred onto a stable surface or into a holder and allowed to evaporate at ambient conditions for a set period of time. A windshield may be used to reduce high air turbulence. 4. The glass capillary is then introduced into an empty", "panel_size": null, "property_name": "headspace_concentration_or_intensity", "scale": "hours_or_timepoint", "substrate": ["headspace"], "time_points": ["1 hr", "2 hrs", "3 hrs", "4 hrs", "5 hrs", "6 hrs"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "1 hr; 2 hrs; 3 hrs; 4 hrs; 5 hrs; 6 hrs; 50/30", "patent_id": "US10138441B2", "provenance": {"citation": "US10138441B2", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US10138441B2/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:0000", "units": "hours", "verbatim_quote": "1. The test and control compositions as described in the Example section are used for the evaluation. 2. Capillaries of about 2 cm to 3.5 cm, with one sealed end are cut from a Sigma Aldrich \u201cStuart\u2122 melting point tube\u201d product code Z673269, or equivalent. A suitable fixed volume chosen between 50 and 200 \u03bcL of the composition is pipetted into the well of a VWR Tissue Culture 96 F well plate, or equivalent. The sealed end of the glass capillary is dipped into the filled well and left for at least 15 secs to wet the surface of the glass. Care must be taken not to contact the glass capillary with the sides of the well by maintaining it straight and approximately in the center of the well. 3. The glass capillary is then removed from the well and inverted or transferred onto a stable surface or into a holder and allowed to evaporate at ambient conditions for a set period of time. A windshield may be used to reduce high air turbulence. 4. The glass capillary is then introduced into an empty 20 mL HS vial, which is immediately closed with a PTFE cap. The time at which this takes place is determined to be time T=initial (i.e., T=10 mins) 5. Multiple glass capillaries are prepared in the same way and left to evaporate at ambient temperature for pre-determined periods of time, such as for example 10, 15, 30 mins, 1 hr, 2 hrs, 3 hrs, 4 hrs, 5 hrs, and up to 6 hrs, before being introduced to the headspace vial and sealed. 6. The HS vial is then analysed on an Agilent GC system 6890 equipped with a Gerstel MPS 2 autosampler, or equivalent, capable of performing SPME injections. A SPME fiber assembly DVB/CAR/PDMS (50/30 \u03bcm, 1 cm length) is required. A GC column such as a DB-5MS, ZB-SMSi models, or equivalent phase, with a length of 30 m, an inner diameter of 0.25 mm and a film thickness of 1 \u03bcm is used. 7. The SPME HS parameters are set to the values indicated as follows:"}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": "example 10", "confidence": 0.9, "construct": {"method_text_verbatim": "5. Multiple glass capillaries are prepared in the same way and left to evaporate at ambient temperature for pre-determined periods of time, such as for example 10, 15, 30 mins, 1 hr, 2 hrs, 3 hrs, 4 hrs, 5 hrs, and up to 6 hrs, before being introduced to the headspace vial and sealed.", "panel_size": null, "property_name": "headspace_concentration_or_intensity", "scale": "hours_or_timepoint", "substrate": ["headspace"], "time_points": ["1 hr", "2 hrs", "3 hrs", "4 hrs", "5 hrs", "6 hrs"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "1 hr; 2 hrs; 3 hrs; 4 hrs; 5 hrs; 6 hrs", "patent_id": "US10138441B2", "provenance": {"citation": "US10138441B2", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US10138441B2/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:0261", "units": "hours", "verbatim_quote": "5. Multiple glass capillaries are prepared in the same way and left to evaporate at ambient temperature for pre-determined periods of time, such as for example 10, 15, 30 mins, 1 hr, 2 hrs, 3 hrs, 4 hrs, 5 hrs, and up to 6 hrs, before being introduced to the headspace vial and sealed."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": "example 10", "confidence": 0.9, "construct": {"method_text_verbatim": "1. The test and control compositions as described in the Example section are used for the evaluation. 2. Capillaries of about 2 cm to 3.5 cm, with one sealed end are cut from a Sigma Aldrich \u201cStuart\u2122 melting point tube\u201d product code Z673269, or equivalent. A suitable fixed volume chosen between 50 and 200 \u03bcL of the composition is pipetted into the well of a VWR Tissue Culture 96 F well plate, or equivalent. The sealed end of the glass capillary is dipped into the filled well and left for at least 15 secs to wet the surface of the glass. Care must be taken not to contact the glass capillary with the sides of the well by maintaining it straight and approximately in the center of the well. 3. The glass capillary is then removed from the well and inverted or transferred onto a stable surface or into a holder and allowed to evaporate at ambient conditions for a set period of time. A windshield may be used to reduce high air turbulence. 4. The glass capillary is then introduced into an empty", "panel_size": null, "property_name": "headspace_concentration_or_intensity", "scale": "hours_or_timepoint", "substrate": ["headspace"], "time_points": ["1 hr", "2 hrs", "3 hrs", "4 hrs", "5 hrs", "6 hrs"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "1 hr; 2 hrs; 3 hrs; 4 hrs; 5 hrs; 6 hrs; 50/30", "patent_id": "US10336966B2", "provenance": {"citation": "US10336966B2", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US10336966B2/en"}, "pub_date": "2018-01-23", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:0000", "units": "hours", "verbatim_quote": "1. The test and control compositions as described in the Example section are used for the evaluation. 2. Capillaries of about 2 cm to 3.5 cm, with one sealed end are cut from a Sigma Aldrich \u201cStuart\u2122 melting point tube\u201d product code Z673269, or equivalent. A suitable fixed volume chosen between 50 and 200 \u03bcL of the composition is pipetted into the well of a VWR Tissue Culture 96 F well plate, or equivalent. The sealed end of the glass capillary is dipped into the filled well and left for at least 15 secs to wet the surface of the glass. Care must be taken not to contact the glass capillary with the sides of the well by maintaining it straight and approximately in the center of the well. 3. The glass capillary is then removed from the well and inverted or transferred onto a stable surface or into a holder and allowed to evaporate at ambient conditions for a set period of time. A windshield may be used to reduce high air turbulence. 4. The glass capillary is then introduced into an empty 20 mL HS vial, which is immediately closed with a PTFE cap. The time at which this takes place is determined to be time T=initial (i.e., T=10 mins). 5. Multiple glass capillaries are prepared in the same way and left to evaporate at ambient temperature for pre-determined periods of time, such as for example 10, 15, 30 mins, 1 hr, 2 hrs, 3 hrs, 4 hrs, 5 hrs, and up to 6 hrs, before being introduced to the headspace vial and sealed. 6. The HS vial is then analysed on an Agilent GC system 6890 equipped with a Gerstel MPS 2 autosampler, or equivalent, capable of performing SPME injections. A SPME fiber assembly DVB/CAR/PDMS (50/30 \u03bcm, 1 cm length) is required. A GC column such as a DB-5MS, ZB-5MSi models, or equivalent phase, with a length of 30 m, an inner diameter of 0.25 mm and a film thickness of 1 \u03bcm is used. 7. The SPME HS parameters are set to the values indicated as follows:"}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": "example 10", "confidence": 0.9, "construct": {"method_text_verbatim": "5. Multiple glass capillaries are prepared in the same way and left to evaporate at ambient temperature for pre-determined periods of time, such as for example 10, 15, 30 mins, 1 hr, 2 hrs, 3 hrs, 4 hrs, 5 hrs, and up to 6 hrs, before being introduced to the headspace vial and sealed.", "panel_size": null, "property_name": "headspace_concentration_or_intensity", "scale": "hours_or_timepoint", "substrate": ["headspace"], "time_points": ["1 hr", "2 hrs", "3 hrs", "4 hrs", "5 hrs", "6 hrs"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "1 hr; 2 hrs; 3 hrs; 4 hrs; 5 hrs; 6 hrs", "patent_id": "US10336966B2", "provenance": {"citation": "US10336966B2", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US10336966B2/en"}, "pub_date": "2018-01-23", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:0262", "units": "hours", "verbatim_quote": "5. Multiple glass capillaries are prepared in the same way and left to evaporate at ambient temperature for pre-determined periods of time, such as for example 10, 15, 30 mins, 1 hr, 2 hrs, 3 hrs, 4 hrs, 5 hrs, and up to 6 hrs, before being introduced to the headspace vial and sealed."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.45, "construct": {"method_text_verbatim": "I. Polymer Assisted Delivery (PAD): This perfume delivery technology uses polymeric materials to deliver perfume materials. Classical coacervation, water soluble or partly soluble to insoluble charged or neutral polymers, liquid crystals, hot melts, hydrogels, perfumed plastics, microcapsules, nano- and micro-latexes, polymeric film formers, and polymeric absorbents, polymeric adsorbents, etc. are some examples. PAD includes but is not limited to: a.) Matrix Systems: The fragrance is dissolved or dispersed in a polymer matrix or particle. Perfumes, for example, may be 1) dispersed into the polymer prior to formulating into the product or 2) added separately from the polymer during or after formulation of the product. Diffusion of perfume from the polymer is a common trigger that allows or increases the rate of perfume release from a polymeric matrix system that is deposited or applied to the desired surface (situs), although many other triggers are know that may control perfume release", "panel_size": null, "property_name": "odor_intensity", "scale": "numeric_unknown", "substrate": null, "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "2005/0003980; 2004/0110648; 2006/003913", "patent_id": "US11844854B2", "provenance": {"citation": "US11844854B2", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US11844854B2/en"}, "pub_date": "2021-03-01", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:0000", "units": "ordinal_ratio", "verbatim_quote": "I. Polymer Assisted Delivery (PAD): This perfume delivery technology uses polymeric materials to deliver perfume materials. Classical coacervation, water soluble or partly soluble to insoluble charged or neutral polymers, liquid crystals, hot melts, hydrogels, perfumed plastics, microcapsules, nano- and micro-latexes, polymeric film formers, and polymeric absorbents, polymeric adsorbents, etc. are some examples. PAD includes but is not limited to: a.) Matrix Systems: The fragrance is dissolved or dispersed in a polymer matrix or particle. Perfumes, for example, may be 1) dispersed into the polymer prior to formulating into the product or 2) added separately from the polymer during or after formulation of the product. Diffusion of perfume from the polymer is a common trigger that allows or increases the rate of perfume release from a polymeric matrix system that is deposited or applied to the desired surface (situs), although many other triggers are know that may control perfume release. Absorption and/or adsorption into or onto polymeric particles, films, solutions, and the like are aspects of this technology. Nano- or micro-particles composed of organic materials (e.g., latexes) are examples. Suitable particles include a wide range of materials including, but not limited to polyacetal, polyacrylate, polyacrylic, polyacrylonitrile, polyamide, polyaryletherketone, polybutadiene, polybutylene, polybutylene terephthalate, polychloroprene, poly ethylene, polyethylene terephthalate, polycyclohexylene dimethylene terephthalate, polycarbonate, polychloroprene, polyhydroxyalkanoate, polyketone, polyester, polyethylene, polyetherimide, polyethersulfone, polyethylenechlorinates, polyimide, polyisoprene, polylactic acid, polymethylpentene, polyphenylene oxide, polyphenylene sulfide, polyphthalamide, polypropylene, polystyrene, polysulfone, polyvinyl acetate, polyvinyl chloride, as well as polymers or copolymers based on acrylonitrile-butadiene, cellulose acetate, ethylene-vinyl acetate, ethylene vinyl alcohol, styrene-butadiene, vinyl acetate-ethylene, and mixtures thereof. \u201cStandard\u201d systems refer to those that are \u201cpre-loaded\u201d with the intent of keeping the pre-loaded perfume associated with the polymer until the moment or moments of perfume release. Such polymers may also suppress the neat product odor and provide a bloom and/or longevity benefit depending on the rate of perfume release. One challenge with such systems is to achieve the ideal balance between 1) in-product stability (keeping perfume inside carrier until you need it) and 2) timely release (during use or from dry situs). Achieving such stability is particularly important during in-product storage and product aging. This challenge is particularly apparent for aqueous-based, surfactant-containing products, such as heavy duty liquid laundry detergents. Many \u201cStandard\u201d matrix systems available effectively become \u201cEquilibrium\u201d systems when formulated into aqueous-based products. One may select an \u201cEquilibrium\u201d system or a Reservoir system, which has acceptable in-product diffusion stability and available triggers for release (e.g., friction). \u201cEquilibrium\u201d systems are those in which the perfume and polymer may be added separately to the product, and the equilibrium interaction between perfume and polymer leads to a benefit at one or more consumer touch points (versus a free perfume control that has no polymer-assisted delivery technology). The polymer may also be pre-loaded with perfume; however, part or all of the perfume may diffuse during in-product storage reaching an equilibrium that includes having desired perfume raw materials (PRMs) associated with the polymer. The polymer then carries the perfume to the surface, and release is typically via perfume diffusion. The use of such equilibrium system polymers has the potential to decrease the neat product odor intensity of the neat product (usually more so in the case of pre-loaded standard system). Deposition of such polymers may serve to \u201cflatten\u201d the release profile and provide increased longevity. As indicated above, such longevity would be achieved by suppressing the initial intensity and may enable the formulator to use more high impact or low odor detection threshold (ODT) or low Kovats Index (KI) PRMs to achieve FMOT benefits without initial intensity that is too strong or distorted. It is important that perfume release occurs within the time frame of the application to impact the desired consumer touch point or touch points. Suitable micro-particles and micro-latexes as well as methods of making same may be found in USPA 2005/0003980 A1. Matrix systems also include hot melt adhesives and perfume plastics. In addition, hydrophobically modified polysaccharides may be formulated into the perfumed product to increase perfume deposition and/or modify perfume release. All such matrix systems, including for example polysaccharides and nanolatexes may be combined with other PDTs, including other PAD systems such as PAD reservoir systems in the form of a perfume microcapsule (PMC). Polymer Assisted Delivery (PAD) matrix systems may include those described in the following references: US Patent Application 2004/0110648 A1 and U.S. Pat. No. 6,531,444. Silicones are also examples of polymers that may be used as PDT, and can provide perfume benefits in a manner similar to the polymer-assisted delivery \u201cmatrix system\u201d. Such a PDT is referred to as silicone-assisted delivery (SAD). One may pre-load silicones with perfume, or use them as an equilibrium system as described for PAD. Suitable silicones as well as making same may be found in USPA 20050143282A1. Functionalized silicones may also be used as described in USPA 2006/003913 A1. Examples of silicones include polydimethylsiloxane and polyalkyldimethylsiloxanes. Other examples include those with amine functionality, which may be used to provide benefits associated with amine-assisted delivery (AAD) and/or polymer-assisted delivery (PAD) and/or amine-reaction products (ARP). Other such examples may be found in USPA 2005/0003980 A1. b.) Reservoir Systems: Reservoir systems are also known as a core-shell type technology, or one in which the fragrance is surrounded by a perfume release controlling membrane, which may serve as a protective shell. The material inside the microcapsule is referred to as the core, internal phase, or fill, whereas the wall is sometimes called a shell, coating, or membrane. Microparticles or pressure sensitive capsules or microcapsules are examples of this technology. Microcapsules of the current invention are formed by a variety of procedures that include, but are not limited to, coating, extrusion, spray-drying, interfacial, in-situ and matrix polymerization. The possible shell materials vary widely in their stability toward water. Among the most stable are polyoxymethyleneurea (PMU)-based materials, which may hold certain PRMs for even long periods of time in aqueous solution (or product). Such systems include but are not limited to urea-formaldehyde and/or melamine-formaldehyde. Gelatin-based microcapsules may be prepared so that they dissolve quickly or slowly in water, depending for example on the degree of cross-linking. Many other capsule wall materials are available and vary in the degree of perfume diffusion stability observed. Without wishing to be bound by theory, the rate of release of perfume from a capsule, for example, once deposited on a surface is typically in reverse order of in-product perfume diffusion stability. As such, urea-formaldehyde and melamine-formaldehyde microcapsules for example, typically require a release mechanism other than, or in addition to, diffusion for release, such as mechanical force (e.g., friction, pressure, shear stress) that serves to break the capsule and increase the rate of perfume (fragrance) release. Other triggers include melting, dissolution, hydrolysis or other chemical reaction, electromagnetic radiation, and the like. Suitable capsule wall materials include, in addition to aminoplasts, polyvinyl alcohol, polyvinyl pyrrolidone, polyethylene glycol, polysaccharides and modified polysaccharides, gel forming proteins, modified celluloses such as carboxymethylcelluloses and hydroxyethylcelluloses, polyacrylates, polyureas, polyurethanes and mixtures thereof. The capsules may be further coated with an additional coating that can improve the deposition and/or retention of the capsule on the desired surface. Suitable coating materials include a cationic polymer selected from the group consisting of selected from the group consisting of poly saccharides, cationically modified starch, cationically modified guar, polysiloxanes, poly diallyl dimethyl ammonium halides, copolymers of poly diallyl dimethyl ammonium chloride and vinyl pyrrolidone, acrylamides, imidazoles, imidazolinium halides, imidazolium halides, poly vinyl amine, copolymers of poly vinyl amine and N-vinyl formamide to the surface of the capsule to form a cationically coated polymer encapsulated material. Typical capsules have a diameter of 1 micron to 500 microns. The use of pre-loaded microcapsules requires the proper ratio of in-product stability and in-use and/or on-surface (on-situs) release, as well as proper selection of PRMs. Microcapsules that are based on urea-formaldehyde and/or melamine-formaldehyde are relatively stable, especially in near neutral aqueous-based solutions. These materials may require a friction trigger which may not be applicable to all product applications. Other microcapsule materials (e.g., gelatin) may be unstable in aqueous-based products and may even provide reduced benefit (versus free perfume control) when in-product aged."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.45, "construct": {"method_text_verbatim": "I. Polymer Assisted Delivery (PAD): This perfume delivery technology uses polymeric materials to deliver perfume materials. Classical coacervation, water soluble or partly soluble to insoluble charged or neutral polymers, liquid crystals, hot melts, hydrogels, perfumed plastics, microcapsules, nano- and micro-latexes, polymeric film formers, and polymeric absorbents, polymeric adsorbents, etc. are some examples. PAD includes but is not limited to: a.) Matrix Systems: The fragrance is dissolved or dispersed in a polymer matrix or particle. Perfumes, for example, may be 1) dispersed into the polymer prior to formulating into the product or 2) added separately from the polymer during or after formulation of the product. Diffusion of perfume from the polymer is a common trigger that allows or increases the rate of perfume release from a polymeric matrix system that is deposited or applied to the desired surface (situs), although many other triggers are know that may control perfume release", "panel_size": null, "property_name": "odor_intensity", "scale": "numeric_unknown", "substrate": null, "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "2005/0003980; 2004/0110648; 2006/003913", "patent_id": "US11844854B2", "provenance": {"citation": "US11844854B2", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US11844854B2/en"}, "pub_date": "2021-03-01", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:0232", "units": "ordinal_ratio", "verbatim_quote": "I. Polymer Assisted Delivery (PAD): This perfume delivery technology uses polymeric materials to deliver perfume materials. Classical coacervation, water soluble or partly soluble to insoluble charged or neutral polymers, liquid crystals, hot melts, hydrogels, perfumed plastics, microcapsules, nano- and micro-latexes, polymeric film formers, and polymeric absorbents, polymeric adsorbents, etc. are some examples. PAD includes but is not limited to: a.) Matrix Systems: The fragrance is dissolved or dispersed in a polymer matrix or particle. Perfumes, for example, may be 1) dispersed into the polymer prior to formulating into the product or 2) added separately from the polymer during or after formulation of the product. Diffusion of perfume from the polymer is a common trigger that allows or increases the rate of perfume release from a polymeric matrix system that is deposited or applied to the desired surface (situs), although many other triggers are know that may control perfume release. Absorption and/or adsorption into or onto polymeric particles, films, solutions, and the like are aspects of this technology. Nano- or micro-particles composed of organic materials (e.g., latexes) are examples. Suitable particles include a wide range of materials including, but not limited to polyacetal, polyacrylate, polyacrylic, polyacrylonitrile, polyamide, polyaryletherketone, polybutadiene, polybutylene, polybutylene terephthalate, polychloroprene, poly ethylene, polyethylene terephthalate, polycyclohexylene dimethylene terephthalate, polycarbonate, polychloroprene, polyhydroxyalkanoate, polyketone, polyester, polyethylene, polyetherimide, polyethersulfone, polyethylenechlorinates, polyimide, polyisoprene, polylactic acid, polymethylpentene, polyphenylene oxide, polyphenylene sulfide, polyphthalamide, polypropylene, polystyrene, polysulfone, polyvinyl acetate, polyvinyl chloride, as well as polymers or copolymers based on acrylonitrile-butadiene, cellulose acetate, ethylene-vinyl acetate, ethylene vinyl alcohol, styrene-butadiene, vinyl acetate-ethylene, and mixtures thereof. \u201cStandard\u201d systems refer to those that are \u201cpre-loaded\u201d with the intent of keeping the pre-loaded perfume associated with the polymer until the moment or moments of perfume release. Such polymers may also suppress the neat product odor and provide a bloom and/or longevity benefit depending on the rate of perfume release. One challenge with such systems is to achieve the ideal balance between 1) in-product stability (keeping perfume inside carrier until you need it) and 2) timely release (during use or from dry situs). Achieving such stability is particularly important during in-product storage and product aging. This challenge is particularly apparent for aqueous-based, surfactant-containing products, such as heavy duty liquid laundry detergents. Many \u201cStandard\u201d matrix systems available effectively become \u201cEquilibrium\u201d systems when formulated into aqueous-based products. One may select an \u201cEquilibrium\u201d system or a Reservoir system, which has acceptable in-product diffusion stability and available triggers for release (e.g., friction). \u201cEquilibrium\u201d systems are those in which the perfume and polymer may be added separately to the product, and the equilibrium interaction between perfume and polymer leads to a benefit at one or more consumer touch points (versus a free perfume control that has no polymer-assisted delivery technology). The polymer may also be pre-loaded with perfume; however, part or all of the perfume may diffuse during in-product storage reaching an equilibrium that includes having desired perfume raw materials (PRMs) associated with the polymer. The polymer then carries the perfume to the surface, and release is typically via perfume diffusion. The use of such equilibrium system polymers has the potential to decrease the neat product odor intensity of the neat product (usually more so in the case of pre-loaded standard system). Deposition of such polymers may serve to \u201cflatten\u201d the release profile and provide increased longevity. As indicated above, such longevity would be achieved by suppressing the initial intensity and may enable the formulator to use more high impact or low odor detection threshold (ODT) or low Kovats Index (KI) PRMs to achieve FMOT benefits without initial intensity that is too strong or distorted. It is important that perfume release occurs within the time frame of the application to impact the desired consumer touch point or touch points. Suitable micro-particles and micro-latexes as well as methods of making same may be found in USPA 2005/0003980 A1. Matrix systems also include hot melt adhesives and perfume plastics. In addition, hydrophobically modified polysaccharides may be formulated into the perfumed product to increase perfume deposition and/or modify perfume release. All such matrix systems, including for example polysaccharides and nanolatexes may be combined with other PDTs, including other PAD systems such as PAD reservoir systems in the form of a perfume microcapsule (PMC). Polymer Assisted Delivery (PAD) matrix systems may include those described in the following references: US Patent Application 2004/0110648 A1 and U.S. Pat. No. 6,531,444. Silicones are also examples of polymers that may be used as PDT, and can provide perfume benefits in a manner similar to the polymer-assisted delivery \u201cmatrix system\u201d. Such a PDT is referred to as silicone-assisted delivery (SAD). One may pre-load silicones with perfume, or use them as an equilibrium system as described for PAD. Suitable silicones as well as making same may be found in USPA 20050143282A1. Functionalized silicones may also be used as described in USPA 2006/003913 A1. Examples of silicones include polydimethylsiloxane and polyalkyldimethylsiloxanes. Other examples include those with amine functionality, which may be used to provide benefits associated with amine-assisted delivery (AAD) and/or polymer-assisted delivery (PAD) and/or amine-reaction products (ARP). Other such examples may be found in USPA 2005/0003980 A1. b.) Reservoir Systems: Reservoir systems are also known as a core-shell type technology, or one in which the fragrance is surrounded by a perfume release controlling membrane, which may serve as a protective shell. The material inside the microcapsule is referred to as the core, internal phase, or fill, whereas the wall is sometimes called a shell, coating, or membrane. Microparticles or pressure sensitive capsules or microcapsules are examples of this technology. Microcapsules of the current invention are formed by a variety of procedures that include, but are not limited to, coating, extrusion, spray-drying, interfacial, in-situ and matrix polymerization. The possible shell materials vary widely in their stability toward water. Among the most stable are polyoxymethyleneurea (PMU)-based materials, which may hold certain PRMs for even long periods of time in aqueous solution (or product). Such systems include but are not limited to urea-formaldehyde and/or melamine-formaldehyde. Gelatin-based microcapsules may be prepared so that they dissolve quickly or slowly in water, depending for example on the degree of cross-linking. Many other capsule wall materials are available and vary in the degree of perfume diffusion stability observed. Without wishing to be bound by theory, the rate of release of perfume from a capsule, for example, once deposited on a surface is typically in reverse order of in-product perfume diffusion stability. As such, urea-formaldehyde and melamine-formaldehyde microcapsules for example, typically require a release mechanism other than, or in addition to, diffusion for release, such as mechanical force (e.g., friction, pressure, shear stress) that serves to break the capsule and increase the rate of perfume (fragrance) release. Other triggers include melting, dissolution, hydrolysis or other chemical reaction, electromagnetic radiation, and the like. Suitable capsule wall materials include, in addition to aminoplasts, polyvinyl alcohol, polyvinyl pyrrolidone, polyethylene glycol, polysaccharides and modified polysaccharides, gel forming proteins, modified celluloses such as carboxymethylcelluloses and hydroxyethylcelluloses, polyacrylates, polyureas, polyurethanes and mixtures thereof. The capsules may be further coated with an additional coating that can improve the deposition and/or retention of the capsule on the desired surface. Suitable coating materials include a cationic polymer selected from the group consisting of selected from the group consisting of poly saccharides, cationically modified starch, cationically modified guar, polysiloxanes, poly diallyl dimethyl ammonium halides, copolymers of poly diallyl dimethyl ammonium chloride and vinyl pyrrolidone, acrylamides, imidazoles, imidazolinium halides, imidazolium halides, poly vinyl amine, copolymers of poly vinyl amine and N-vinyl formamide to the surface of the capsule to form a cationically coated polymer encapsulated material. Typical capsules have a diameter of 1 micron to 500 microns. The use of pre-loaded microcapsules requires the proper ratio of in-product stability and in-use and/or on-surface (on-situs) release, as well as proper selection of PRMs. Microcapsules that are based on urea-formaldehyde and/or melamine-formaldehyde are relatively stable, especially in near neutral aqueous-based solutions. These materials may require a friction trigger which may not be applicable to all product applications. Other microcapsule materials (e.g., gelatin) may be unstable in aqueous-based products and may even provide reduced benefit (versus free perfume control) when in-product aged."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.45, "construct": {"method_text_verbatim": "a.) Matrix Systems: The fragrance is dissolved or dispersed in a polymer matrix or particle. Perfumes, for example, may be 1) dispersed into the polymer prior to formulating into the product or 2) added separately from the polymer during or after formulation of the product. Diffusion of perfume from the polymer is a common trigger that allows or increases the rate of perfume release from a polymeric matrix system that is deposited or applied to the desired surface (situs), although many other triggers are know that may control perfume release. Absorption and/or adsorption into or onto polymeric particles, films, solutions, and the like are aspects of this technology. Nano- or micro-particles composed of organic materials (e.g., latexes) are examples. Suitable particles include a wide range of materials including, but not limited to polyacetal, polyacrylate, polyacrylic, polyacrylonitrile, polyamide, polyaryletherketone, polybutadiene, polybutylene, polybutylene terephthalate, polychlor", "panel_size": null, "property_name": "odor_intensity", "scale": "numeric_unknown", "substrate": null, "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "2005/0003980; 2004/0110648; 2006/003913", "patent_id": "US11844854B2", "provenance": {"citation": "US11844854B2", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US11844854B2/en"}, "pub_date": "2021-03-01", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:0233", "units": "ordinal_ratio", "verbatim_quote": "a.) Matrix Systems: The fragrance is dissolved or dispersed in a polymer matrix or particle. Perfumes, for example, may be 1) dispersed into the polymer prior to formulating into the product or 2) added separately from the polymer during or after formulation of the product. Diffusion of perfume from the polymer is a common trigger that allows or increases the rate of perfume release from a polymeric matrix system that is deposited or applied to the desired surface (situs), although many other triggers are know that may control perfume release. Absorption and/or adsorption into or onto polymeric particles, films, solutions, and the like are aspects of this technology. Nano- or micro-particles composed of organic materials (e.g., latexes) are examples. Suitable particles include a wide range of materials including, but not limited to polyacetal, polyacrylate, polyacrylic, polyacrylonitrile, polyamide, polyaryletherketone, polybutadiene, polybutylene, polybutylene terephthalate, polychloroprene, poly ethylene, polyethylene terephthalate, polycyclohexylene dimethylene terephthalate, polycarbonate, polychloroprene, polyhydroxyalkanoate, polyketone, polyester, polyethylene, polyetherimide, polyethersulfone, polyethylenechlorinates, polyimide, polyisoprene, polylactic acid, polymethylpentene, polyphenylene oxide, polyphenylene sulfide, polyphthalamide, polypropylene, polystyrene, polysulfone, polyvinyl acetate, polyvinyl chloride, as well as polymers or copolymers based on acrylonitrile-butadiene, cellulose acetate, ethylene-vinyl acetate, ethylene vinyl alcohol, styrene-butadiene, vinyl acetate-ethylene, and mixtures thereof. \u201cStandard\u201d systems refer to those that are \u201cpre-loaded\u201d with the intent of keeping the pre-loaded perfume associated with the polymer until the moment or moments of perfume release. Such polymers may also suppress the neat product odor and provide a bloom and/or longevity benefit depending on the rate of perfume release. One challenge with such systems is to achieve the ideal balance between 1) in-product stability (keeping perfume inside carrier until you need it) and 2) timely release (during use or from dry situs). Achieving such stability is particularly important during in-product storage and product aging. This challenge is particularly apparent for aqueous-based, surfactant-containing products, such as heavy duty liquid laundry detergents. Many \u201cStandard\u201d matrix systems available effectively become \u201cEquilibrium\u201d systems when formulated into aqueous-based products. One may select an \u201cEquilibrium\u201d system or a Reservoir system, which has acceptable in-product diffusion stability and available triggers for release (e.g., friction). \u201cEquilibrium\u201d systems are those in which the perfume and polymer may be added separately to the product, and the equilibrium interaction between perfume and polymer leads to a benefit at one or more consumer touch points (versus a free perfume control that has no polymer-assisted delivery technology). The polymer may also be pre-loaded with perfume; however, part or all of the perfume may diffuse during in-product storage reaching an equilibrium that includes having desired perfume raw materials (PRMs) associated with the polymer. The polymer then carries the perfume to the surface, and release is typically via perfume diffusion. The use of such equilibrium system polymers has the potential to decrease the neat product odor intensity of the neat product (usually more so in the case of pre-loaded standard system). Deposition of such polymers may serve to \u201cflatten\u201d the release profile and provide increased longevity. As indicated above, such longevity would be achieved by suppressing the initial intensity and may enable the formulator to use more high impact or low odor detection threshold (ODT) or low Kovats Index (KI) PRMs to achieve FMOT benefits without initial intensity that is too strong or distorted. It is important that perfume release occurs within the time frame of the application to impact the desired consumer touch point or touch points. Suitable micro-particles and micro-latexes as well as methods of making same may be found in USPA 2005/0003980 A1. Matrix systems also include hot melt adhesives and perfume plastics. In addition, hydrophobically modified polysaccharides may be formulated into the perfumed product to increase perfume deposition and/or modify perfume release. All such matrix systems, including for example polysaccharides and nanolatexes may be combined with other PDTs, including other PAD systems such as PAD reservoir systems in the form of a perfume microcapsule (PMC). Polymer Assisted Delivery (PAD) matrix systems may include those described in the following references: US Patent Application 2004/0110648 A1 and U.S. Pat. No. 6,531,444. Silicones are also examples of polymers that may be used as PDT, and can provide perfume benefits in a manner similar to the polymer-assisted delivery \u201cmatrix system\u201d. Such a PDT is referred to as silicone-assisted delivery (SAD). One may pre-load silicones with perfume, or use them as an equilibrium system as described for PAD. Suitable silicones as well as making same may be found in USPA 20050143282A1. Functionalized silicones may also be used as described in USPA 2006/003913 A1. Examples of silicones include polydimethylsiloxane and polyalkyldimethylsiloxanes. Other examples include those with amine functionality, which may be used to provide benefits associated with amine-assisted delivery (AAD) and/or polymer-assisted delivery (PAD) and/or amine-reaction products (ARP). Other such examples may be found in USPA 2005/0003980 A1."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.45, "construct": {"method_text_verbatim": "\u201cStandard\u201d systems refer to those that are \u201cpre-loaded\u201d with the intent of keeping the pre-loaded perfume associated with the polymer until the moment or moments of perfume release. Such polymers may also suppress the neat product odor and provide a bloom and/or longevity benefit depending on the rate of perfume release. One challenge with such systems is to achieve the ideal balance between 1) in-product stability (keeping perfume inside carrier until you need it) and 2) timely release (during use or from dry situs). Achieving such stability is particularly important during in-product storage and product aging. This challenge is particularly apparent for aqueous-based, surfactant-containing products, such as heavy duty liquid laundry detergents. Many \u201cStandard\u201d matrix systems available effectively become \u201cEquilibrium\u201d systems when formulated into aqueous-based products. One may select an \u201cEquilibrium\u201d system or a Reservoir system, which has acceptable in-product diffusion stability an", "panel_size": null, "property_name": "odor_intensity", "scale": "numeric_unknown", "substrate": null, "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "2005/0003980; 2004/0110648", "patent_id": "US11844854B2", "provenance": {"citation": "US11844854B2", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US11844854B2/en"}, "pub_date": "2021-03-01", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:0234", "units": "ordinal_ratio", "verbatim_quote": "\u201cStandard\u201d systems refer to those that are \u201cpre-loaded\u201d with the intent of keeping the pre-loaded perfume associated with the polymer until the moment or moments of perfume release. Such polymers may also suppress the neat product odor and provide a bloom and/or longevity benefit depending on the rate of perfume release. One challenge with such systems is to achieve the ideal balance between 1) in-product stability (keeping perfume inside carrier until you need it) and 2) timely release (during use or from dry situs). Achieving such stability is particularly important during in-product storage and product aging. This challenge is particularly apparent for aqueous-based, surfactant-containing products, such as heavy duty liquid laundry detergents. Many \u201cStandard\u201d matrix systems available effectively become \u201cEquilibrium\u201d systems when formulated into aqueous-based products. One may select an \u201cEquilibrium\u201d system or a Reservoir system, which has acceptable in-product diffusion stability and available triggers for release (e.g., friction). \u201cEquilibrium\u201d systems are those in which the perfume and polymer may be added separately to the product, and the equilibrium interaction between perfume and polymer leads to a benefit at one or more consumer touch points (versus a free perfume control that has no polymer-assisted delivery technology). The polymer may also be pre-loaded with perfume; however, part or all of the perfume may diffuse during in-product storage reaching an equilibrium that includes having desired perfume raw materials (PRMs) associated with the polymer. The polymer then carries the perfume to the surface, and release is typically via perfume diffusion. The use of such equilibrium system polymers has the potential to decrease the neat product odor intensity of the neat product (usually more so in the case of pre-loaded standard system). Deposition of such polymers may serve to \u201cflatten\u201d the release profile and provide increased longevity. As indicated above, such longevity would be achieved by suppressing the initial intensity and may enable the formulator to use more high impact or low odor detection threshold (ODT) or low Kovats Index (KI) PRMs to achieve FMOT benefits without initial intensity that is too strong or distorted. It is important that perfume release occurs within the time frame of the application to impact the desired consumer touch point or touch points. Suitable micro-particles and micro-latexes as well as methods of making same may be found in USPA 2005/0003980 A1. Matrix systems also include hot melt adhesives and perfume plastics. In addition, hydrophobically modified polysaccharides may be formulated into the perfumed product to increase perfume deposition and/or modify perfume release. All such matrix systems, including for example polysaccharides and nanolatexes may be combined with other PDTs, including other PAD systems such as PAD reservoir systems in the form of a perfume microcapsule (PMC). Polymer Assisted Delivery (PAD) matrix systems may include those described in the following references: US Patent Application 2004/0110648 A1 and U.S. Pat. No. 6,531,444."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.45, "construct": {"method_text_verbatim": "a.) Matrix Systems: The fragrance is dissolved or dispersed in a polymer matrix or particle. Perfumes, for example, may be 1) dispersed into the polymer prior to formulating into the product or 2) added separately from the polymer during or after formulation of the product. Diffusion of perfume from the polymer is a common trigger that allows or increases the rate of perfume release from a polymeric matrix system that is deposited or applied to the desired surface (situs), although many other triggers are know that may control perfume release. Absorption and/or adsorption into or onto polymeric particles, films, solutions, and the like are aspects of this technology. Nano- or micro-particles composed of organic materials (e.g., latexes) are examples. Suitable particles include a wide range of materials including, but not limited to polyacetal, polyacrylate, polyacrylic, polyacrylonitrile, polyamide, polyaryletherketone, polybutadiene, polybutylene, polybutylene terephthalate, polychlor", "panel_size": null, "property_name": "odor_intensity", "scale": "numeric_unknown", "substrate": null, "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "2005/0003980; 2004/0110648; 2006/003913", "patent_id": "US10952951B2", "provenance": {"citation": "US10952951B2", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US10952951B2/en"}, "pub_date": "2018-11-01", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:0000", "units": "ordinal_ratio", "verbatim_quote": "a.) Matrix Systems: The fragrance is dissolved or dispersed in a polymer matrix or particle. Perfumes, for example, may be 1) dispersed into the polymer prior to formulating into the product or 2) added separately from the polymer during or after formulation of the product. Diffusion of perfume from the polymer is a common trigger that allows or increases the rate of perfume release from a polymeric matrix system that is deposited or applied to the desired surface (situs), although many other triggers are know that may control perfume release. Absorption and/or adsorption into or onto polymeric particles, films, solutions, and the like are aspects of this technology. Nano- or micro-particles composed of organic materials (e.g., latexes) are examples. Suitable particles include a wide range of materials including, but not limited to polyacetal, polyacrylate, polyacrylic, polyacrylonitrile, polyamide, polyaryletherketone, polybutadiene, polybutylene, polybutylene terephthalate, polychloroprene, poly ethylene, polyethylene terephthalate, polycyclohexylene dimethylene terephthalate, polycarbonate, polychloroprene, polyhydroxyalkanoate, polyketone, polyester, polyethylene, polyetherimide, polyethersulfone, polyethylenechlorinates, polyimide, polyisoprene, polylactic acid, polymethylpentene, polyphenylene oxide, polyphenylene sulfide, polyphthalamide, polypropylene, polystyrene, polysulfone, polyvinyl acetate, polyvinyl chloride, as well as polymers or copolymers based on acrylonitrile-butadiene, cellulose acetate, ethylene-vinyl acetate, ethylene vinyl alcohol, styrene-butadiene, vinyl acetate-ethylene, and mixtures thereof. \u201cStandard\u201d systems refer to those that are \u201cpre-loaded\u201d with the intent of keeping the pre-loaded perfume associated with the polymer until the moment or moments of perfume release. Such polymers may also suppress the neat product odor and provide a bloom and/or longevity benefit depending on the rate of perfume release. One challenge with such systems is to achieve the ideal balance between 1) in-product stability (keeping perfume inside carrier until you need it) and 2) timely release (during use or from dry situs). Achieving such stability is particularly important during in-product storage and product aging. This challenge is particularly apparent for aqueous-based, surfactant-containing products, such as heavy duty liquid laundry detergents. Many \u201cStandard\u201d matrix systems available effectively become \u201cEquilibrium\u201d systems when formulated into aqueous-based products. One may select an \u201cEquilibrium\u201d system or a Reservoir system, which has acceptable in-product diffusion stability and available triggers for release (e.g., friction). \u201cEquilibrium\u201d systems are those in which the perfume and polymer may be added separately to the product, and the equilibrium interaction between perfume and polymer leads to a benefit at one or more consumer touch points (versus a free perfume control that has no polymer-assisted delivery technology). The polymer may also be pre-loaded with perfume; however, part or all of the perfume may diffuse during in-product storage reaching an equilibrium that includes having desired perfume raw materials (PRMs) associated with the polymer. The polymer then carries the perfume to the surface, and release is typically via perfume diffusion. The use of such equilibrium system polymers has the potential to decrease the neat product odor intensity of the neat product (usually more so in the case of pre-loaded standard system). Deposition of such polymers may serve to \u201cflatten\u201d the release profile and provide increased longevity. As indicated above, such longevity would be achieved by suppressing the initial intensity and may enable the formulator to use more high impact or low odor detection threshold (ODT) or low Kovats Index (KI) PRMs to achieve FMOT benefits without initial intensity that is too strong or distorted. It is important that perfume release occurs within the time frame of the application to impact the desired consumer touch point or touch points. Suitable micro-particles and micro-latexes as well as methods of making same may be found in USPA 2005/0003980 A1. Matrix systems also include hot melt adhesives and perfume plastics. In addition, hydrophobically modified polysaccharides may be formulated into the perfumed product to increase perfume deposition and/or modify perfume release. All such matrix systems, including for example polysaccharides and nanolatexes may be combined with other PDTs, including other PAD systems such as PAD reservoir systems in the form of a perfume microcapsule (PMC). Polymer Assisted Delivery (PAD) matrix systems may include those described in the following references: US Patent Application 2004/0110648 A1 and U.S. Pat. No. 6,531,444. Silicones are also examples of polymers that may be used as PDT, and can provide perfume benefits in a manner similar to the polymer-assisted delivery \u201cmatrix system\u201d. Such a PDT is referred to as silicone-assisted delivery (SAD). One may pre-load silicones with perfume, or use them as an equilibrium system as described for PAD. Suitable silicones as well as making same may be found in USPA 20050143282A1. Functionalized silicones may also be used as described in USPA 2006/003913 A1. Examples of silicones include polydimethylsiloxane and polyalkyldimethylsiloxanes. Other examples include those with amine functionality, which may be used to provide benefits associated with amine-assisted delivery (AAD) and/or polymer-assisted delivery (PAD) and/or amine-reaction products (ARP). Other such examples may be found in USPA 2005/0003980 A1. b.) Reservoir Systems: Reservoir systems are also known as a core-shell type technology, or one in which the fragrance is surrounded by a perfume release controlling membrane, which may serve as a protective shell. The material inside the microcapsule is referred to as the core, internal phase, or fill, whereas the wall is sometimes called a shell, coating, or membrane. Microparticles or pressure sensitive capsules or microcapsules are examples of this technology. Microcapsules of the current invention are formed by a variety of procedures that include, but are not limited to, coating, extrusion, spray-drying, interfacial, in-situ and matrix polymerization. The possible shell materials vary widely in their stability toward water. Among the most stable are polyoxymethyleneurea (PMU)-based materials, which may hold certain PRMs for even long periods of time in aqueous solution (or product). Such systems include but are not limited to urea-formaldehyde and/or melamine-formaldehyde. Gelatin-based microcapsules may be prepared so that they dissolve quickly or slowly in water, depending for example on the degree of cross-linking. Many other capsule wall materials are available and vary in the degree of perfume diffusion stability observed. Without wishing to be bound by theory, the rate of release of perfume from a capsule, for example, once deposited on a surface is typically in reverse order of in-product perfume diffusion stability. As such, urea-formaldehyde and melamine-formaldehyde microcapsules for example, typically require a release mechanism other than, or in addition to, diffusion for release, such as mechanical force (e.g., friction, pressure, shear stress) that serves to break the capsule and increase the rate of perfume (fragrance) release. Other triggers include melting, dissolution, hydrolysis or other chemical reaction, electromagnetic radiation, and the like. Suitable capsule wall materials include, in addition to aminoplasts, polyvinyl alcohol, polyvinyl pyrrolidone, polyethylene glycol, polysaccharides and modified polysaccharides, gel forming proteins, modified celluloses such as carboxymethylcelluloses and hydroxyethylcelluloses, polyacrylates, polyureas, polyurethanes and mixtures thereof. The capsules may be further coated with an additional coating that can improve the deposition and/or retention of the capsule on the desired surface. Suitable coating materials include a cationic polymer selected from the group consisting of selected from the group consisting of polysaccharides, cationically modified starch, cationically modified guar, polysiloxanes, poly diallyl dimethyl ammonium halides, copolymers of poly diallyl dimethyl ammonium chloride and vinyl pyrrolidone, acrylamides, imidazoles, imidazolinium halides, imidazolium halides, poly vinyl amine, copolymers of poly vinyl amine and N-vinyl formamide to the surface of the capsule to form a cationically coated polymer encapsulated material. Typical capsules have a diameter of 1 micron to 500 microns. The use of pre-loaded microcapsules requires the proper ratio of in-product stability and in-use and/or on-surface (on-situs) release, as well as proper selection of PRMs. Microcapsules that are based on urea-formaldehyde and/or melamine-formaldehyde are relatively stable, especially in near neutral aqueous-based solutions. These materials may require a friction trigger which may not be applicable to all product applications. Other microcapsule materials (e.g., gelatin) may be unstable in aqueous-based products and may even provide reduced benefit (versus free perfume control) when in-product aged. II. Molecule-Assisted Delivery (MAD):"}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.45, "construct": {"method_text_verbatim": "a.) Matrix Systems: The fragrance is dissolved or dispersed in a polymer matrix or particle. Perfumes, for example, may be 1) dispersed into the polymer prior to formulating into the product or 2) added separately from the polymer during or after formulation of the product. Diffusion of perfume from the polymer is a common trigger that allows or increases the rate of perfume release from a polymeric matrix system that is deposited or applied to the desired surface (situs), although many other triggers are know that may control perfume release. Absorption and/or adsorption into or onto polymeric particles, films, solutions, and the like are aspects of this technology. Nano- or micro-particles composed of organic materials (e.g., latexes) are examples. Suitable particles include a wide range of materials including, but not limited to polyacetal, polyacrylate, polyacrylic, polyacrylonitrile, polyamide, polyaryletherketone, polybutadiene, polybutylene, polybutylene terephthalate, polychlor", "panel_size": null, "property_name": "odor_intensity", "scale": "numeric_unknown", "substrate": null, "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "2005/0003980; 2004/0110648; 2006/003913", "patent_id": "US10952951B2", "provenance": {"citation": "US10952951B2", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US10952951B2/en"}, "pub_date": "2018-11-01", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:0229", "units": "ordinal_ratio", "verbatim_quote": "a.) Matrix Systems: The fragrance is dissolved or dispersed in a polymer matrix or particle. Perfumes, for example, may be 1) dispersed into the polymer prior to formulating into the product or 2) added separately from the polymer during or after formulation of the product. Diffusion of perfume from the polymer is a common trigger that allows or increases the rate of perfume release from a polymeric matrix system that is deposited or applied to the desired surface (situs), although many other triggers are know that may control perfume release. Absorption and/or adsorption into or onto polymeric particles, films, solutions, and the like are aspects of this technology. Nano- or micro-particles composed of organic materials (e.g., latexes) are examples. Suitable particles include a wide range of materials including, but not limited to polyacetal, polyacrylate, polyacrylic, polyacrylonitrile, polyamide, polyaryletherketone, polybutadiene, polybutylene, polybutylene terephthalate, polychloroprene, poly ethylene, polyethylene terephthalate, polycyclohexylene dimethylene terephthalate, polycarbonate, polychloroprene, polyhydroxyalkanoate, polyketone, polyester, polyethylene, polyetherimide, polyethersulfone, polyethylenechlorinates, polyimide, polyisoprene, polylactic acid, polymethylpentene, polyphenylene oxide, polyphenylene sulfide, polyphthalamide, polypropylene, polystyrene, polysulfone, polyvinyl acetate, polyvinyl chloride, as well as polymers or copolymers based on acrylonitrile-butadiene, cellulose acetate, ethylene-vinyl acetate, ethylene vinyl alcohol, styrene-butadiene, vinyl acetate-ethylene, and mixtures thereof. \u201cStandard\u201d systems refer to those that are \u201cpre-loaded\u201d with the intent of keeping the pre-loaded perfume associated with the polymer until the moment or moments of perfume release. Such polymers may also suppress the neat product odor and provide a bloom and/or longevity benefit depending on the rate of perfume release. One challenge with such systems is to achieve the ideal balance between 1) in-product stability (keeping perfume inside carrier until you need it) and 2) timely release (during use or from dry situs). Achieving such stability is particularly important during in-product storage and product aging. This challenge is particularly apparent for aqueous-based, surfactant-containing products, such as heavy duty liquid laundry detergents. Many \u201cStandard\u201d matrix systems available effectively become \u201cEquilibrium\u201d systems when formulated into aqueous-based products. One may select an \u201cEquilibrium\u201d system or a Reservoir system, which has acceptable in-product diffusion stability and available triggers for release (e.g., friction). \u201cEquilibrium\u201d systems are those in which the perfume and polymer may be added separately to the product, and the equilibrium interaction between perfume and polymer leads to a benefit at one or more consumer touch points (versus a free perfume control that has no polymer-assisted delivery technology). The polymer may also be pre-loaded with perfume; however, part or all of the perfume may diffuse during in-product storage reaching an equilibrium that includes having desired perfume raw materials (PRMs) associated with the polymer. The polymer then carries the perfume to the surface, and release is typically via perfume diffusion. The use of such equilibrium system polymers has the potential to decrease the neat product odor intensity of the neat product (usually more so in the case of pre-loaded standard system). Deposition of such polymers may serve to \u201cflatten\u201d the release profile and provide increased longevity. As indicated above, such longevity would be achieved by suppressing the initial intensity and may enable the formulator to use more high impact or low odor detection threshold (ODT) or low Kovats Index (KI) PRMs to achieve FMOT benefits without initial intensity that is too strong or distorted. It is important that perfume release occurs within the time frame of the application to impact the desired consumer touch point or touch points. Suitable micro-particles and micro-latexes as well as methods of making same may be found in USPA 2005/0003980 A1. Matrix systems also include hot melt adhesives and perfume plastics. In addition, hydrophobically modified polysaccharides may be formulated into the perfumed product to increase perfume deposition and/or modify perfume release. All such matrix systems, including for example polysaccharides and nanolatexes may be combined with other PDTs, including other PAD systems such as PAD reservoir systems in the form of a perfume microcapsule (PMC). Polymer Assisted Delivery (PAD) matrix systems may include those described in the following references: US Patent Application 2004/0110648 A1 and U.S. Pat. No. 6,531,444. Silicones are also examples of polymers that may be used as PDT, and can provide perfume benefits in a manner similar to the polymer-assisted delivery \u201cmatrix system\u201d. Such a PDT is referred to as silicone-assisted delivery (SAD). One may pre-load silicones with perfume, or use them as an equilibrium system as described for PAD. Suitable silicones as well as making same may be found in USPA 20050143282A1. Functionalized silicones may also be used as described in USPA 2006/003913 A1. Examples of silicones include polydimethylsiloxane and polyalkyldimethylsiloxanes. Other examples include those with amine functionality, which may be used to provide benefits associated with amine-assisted delivery (AAD) and/or polymer-assisted delivery (PAD) and/or amine-reaction products (ARP). Other such examples may be found in USPA 2005/0003980 A1."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.45, "construct": {"method_text_verbatim": "\u201cStandard\u201d systems refer to those that are \u201cpre-loaded\u201d with the intent of keeping the pre-loaded perfume associated with the polymer until the moment or moments of perfume release. Such polymers may also suppress the neat product odor and provide a bloom and/or longevity benefit depending on the rate of perfume release. One challenge with such systems is to achieve the ideal balance between 1) in-product stability (keeping perfume inside carrier until you need it) and 2) timely release (during use or from dry situs). Achieving such stability is particularly important during in-product storage and product aging. This challenge is particularly apparent for aqueous-based, surfactant-containing products, such as heavy duty liquid laundry detergents. Many \u201cStandard\u201d matrix systems available effectively become \u201cEquilibrium\u201d systems when formulated into aqueous-based products. One may select an \u201cEquilibrium\u201d system or a Reservoir system, which has acceptable in-product diffusion stability an", "panel_size": null, "property_name": "odor_intensity", "scale": "numeric_unknown", "substrate": null, "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "2005/0003980; 2004/0110648", "patent_id": "US10952951B2", "provenance": {"citation": "US10952951B2", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US10952951B2/en"}, "pub_date": "2018-11-01", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:0230", "units": "ordinal_ratio", "verbatim_quote": "\u201cStandard\u201d systems refer to those that are \u201cpre-loaded\u201d with the intent of keeping the pre-loaded perfume associated with the polymer until the moment or moments of perfume release. Such polymers may also suppress the neat product odor and provide a bloom and/or longevity benefit depending on the rate of perfume release. One challenge with such systems is to achieve the ideal balance between 1) in-product stability (keeping perfume inside carrier until you need it) and 2) timely release (during use or from dry situs). Achieving such stability is particularly important during in-product storage and product aging. This challenge is particularly apparent for aqueous-based, surfactant-containing products, such as heavy duty liquid laundry detergents. Many \u201cStandard\u201d matrix systems available effectively become \u201cEquilibrium\u201d systems when formulated into aqueous-based products. One may select an \u201cEquilibrium\u201d system or a Reservoir system, which has acceptable in-product diffusion stability and available triggers for release (e.g., friction). \u201cEquilibrium\u201d systems are those in which the perfume and polymer may be added separately to the product, and the equilibrium interaction between perfume and polymer leads to a benefit at one or more consumer touch points (versus a free perfume control that has no polymer-assisted delivery technology). The polymer may also be pre-loaded with perfume; however, part or all of the perfume may diffuse during in-product storage reaching an equilibrium that includes having desired perfume raw materials (PRMs) associated with the polymer. The polymer then carries the perfume to the surface, and release is typically via perfume diffusion. The use of such equilibrium system polymers has the potential to decrease the neat product odor intensity of the neat product (usually more so in the case of pre-loaded standard system). Deposition of such polymers may serve to \u201cflatten\u201d the release profile and provide increased longevity. As indicated above, such longevity would be achieved by suppressing the initial intensity and may enable the formulator to use more high impact or low odor detection threshold (ODT) or low Kovats Index (KI) PRMs to achieve FMOT benefits without initial intensity that is too strong or distorted. It is important that perfume release occurs within the time frame of the application to impact the desired consumer touch point or touch points. Suitable micro-particles and micro-latexes as well as methods of making same may be found in USPA 2005/0003980 A1. Matrix systems also include hot melt adhesives and perfume plastics. In addition, hydrophobically modified polysaccharides may be formulated into the perfumed product to increase perfume deposition and/or modify perfume release. All such matrix systems, including for example polysaccharides and nanolatexes may be combined with other PDTs, including other PAD systems such as PAD reservoir systems in the form of a perfume microcapsule (PMC). Polymer Assisted Delivery (PAD) matrix systems may include those described in the following references: US Patent Application 2004/0110648 A1 and U.S. Pat. No. 6,531,444."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.45, "construct": {"method_text_verbatim": "a.) Matrix Systems: The fragrance is dissolved or dispersed in a polymer matrix or particle. Perfumes, for example, may be 1) dispersed into the polymer prior to formulating into the product or 2) added separately from the polymer during or after formulation of the product. Diffusion of perfume from the polymer is a common trigger that allows or increases the rate of perfume release from a polymeric matrix system that is deposited or applied to the desired surface (situs), although many other triggers are know that may control perfume release. Absorption and/or adsorption into or onto polymeric particles, films, solutions, and the like are aspects of this technology. Nano- or micro-particles composed of organic materials (e.g., latexes) are examples. Suitable particles include a wide range of materials including, but not limited to polyacetal, polyacrylate, polyacrylic, polyacrylonitrile, polyamide, polyaryletherketone, polybutadiene, polybutylene, polybutylene terephthalate, polychlor", "panel_size": null, "property_name": "odor_intensity", "scale": "numeric_unknown", "substrate": null, "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "2005/0003980; 2004/0110648; 2006/003913", "patent_id": "US20210177721A1", "provenance": {"citation": "US20210177721A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20210177721A1/en"}, "pub_date": "2021-03-01", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:0000", "units": "ordinal_ratio", "verbatim_quote": "a.) Matrix Systems: The fragrance is dissolved or dispersed in a polymer matrix or particle. Perfumes, for example, may be 1) dispersed into the polymer prior to formulating into the product or 2) added separately from the polymer during or after formulation of the product. Diffusion of perfume from the polymer is a common trigger that allows or increases the rate of perfume release from a polymeric matrix system that is deposited or applied to the desired surface (situs), although many other triggers are know that may control perfume release. Absorption and/or adsorption into or onto polymeric particles, films, solutions, and the like are aspects of this technology. Nano- or micro-particles composed of organic materials (e.g., latexes) are examples. Suitable particles include a wide range of materials including, but not limited to polyacetal, polyacrylate, polyacrylic, polyacrylonitrile, polyamide, polyaryletherketone, polybutadiene, polybutylene, polybutylene terephthalate, polychloroprene, poly ethylene, polyethylene terephthalate, polycyclohexylene dimethylene terephthalate, polycarbonate, polychloroprene, polyhydroxyalkanoate, polyketone, polyester, polyethylene, polyetherimide, polyethersulfone, polyethylenechlorinates, polyimide, polyisoprene, polylactic acid, polymethylpentene, polyphenylene oxide, polyphenylene sulfide, polyphthalamide, polypropylene, polystyrene, polysulfone, polyvinyl acetate, polyvinyl chloride, as well as polymers or copolymers based on acrylonitrile-butadiene, cellulose acetate, ethylene-vinyl acetate, ethylene vinyl alcohol, styrene-butadiene, vinyl acetate-ethylene, and mixtures thereof. \u201cStandard\u201d systems refer to those that are \u201cpre-loaded\u201d with the intent of keeping the pre-loaded perfume associated with the polymer until the moment or moments of perfume release. Such polymers may also suppress the neat product odor and provide a bloom and/or longevity benefit depending on the rate of perfume release. One challenge with such systems is to achieve the ideal balance between 1) in-product stability (keeping perfume inside carrier until you need it) and 2) timely release (during use or from dry situs). Achieving such stability is particularly important during in-product storage and product aging. This challenge is particularly apparent for aqueous-based, surfactant-containing products, such as heavy duty liquid laundry detergents. Many \u201cStandard\u201d matrix systems available effectively become \u201cEquilibrium\u201d systems when formulated into aqueous-based products. One may select an \u201cEquilibrium\u201d system or a Reservoir system, which has acceptable in-product diffusion stability and available triggers for release (e.g., friction). \u201cEquilibrium\u201d systems are those in which the perfume and polymer may be added separately to the product, and the equilibrium interaction between perfume and polymer leads to a benefit at one or more consumer touch points (versus a free perfume control that has no polymer-assisted delivery technology). The polymer may also be pre-loaded with perfume; however, part or all of the perfume may diffuse during in-product storage reaching an equilibrium that includes having desired perfume raw materials (PRMs) associated with the polymer. The polymer then carries the perfume to the surface, and release is typically via perfume diffusion. The use of such equilibrium system polymers has the potential to decrease the neat product odor intensity of the neat product (usually more so in the case of pre-loaded standard system). Deposition of such polymers may serve to \u201cflatten\u201d the release profile and provide increased longevity. As indicated above, such longevity would be achieved by suppressing the initial intensity and may enable the formulator to use more high impact or low odor detection threshold (ODT) or low Kovats Index (KI) PRMs to achieve FMOT benefits without initial intensity that is too strong or distorted. It is important that perfume release occurs within the time frame of the application to impact the desired consumer touch point or touch points. Suitable micro-particles and micro-latexes as well as methods of making same may be found in USPA 2005/0003980 A1. Matrix systems also include hot melt adhesives and perfume plastics. In addition, hydrophobically modified polysaccharides may be formulated into the perfumed product to increase perfume deposition and/or modify perfume release. All such matrix systems, including for example polysaccharides and nanolatexes may be combined with other PDTs, including other PAD systems such as PAD reservoir systems in the form of a perfume microcapsule (PMC). Polymer Assisted Delivery (PAD) matrix systems may include those described in the following references: US Patent Application 2004/0110648 A1 and U.S. Pat. No. 6,531,444. Silicones are also examples of polymers that may be used as PDT, and can provide perfume benefits in a manner similar to the polymer-assisted delivery \u201cmatrix system\u201d. Such a PDT is referred to as silicone-assisted delivery (SAD). One may pre-load silicones with perfume, or use them as an equilibrium system as described for PAD. Suitable silicones as well as making same may be found in USPA 20050143282A1. Functionalized silicones may also be used as described in USPA 2006/003913 A1. Examples of silicones include polydimethylsiloxane and polyalkyldimethylsiloxanes. Other examples include those with amine functionality, which may be used to provide benefits associated with amine-assisted delivery (AAD) and/or polymer-assisted delivery (PAD) and/or amine-reaction products (ARP). Other such examples may be found in USPA 2005/0003980 A1. b.) Reservoir Systems: Reservoir systems are also known as a core-shell type technology, or one in which the fragrance is surrounded by a perfume release controlling membrane, which may serve as a protective shell. The material inside the microcapsule is referred to as the core, internal phase, or fill, whereas the wall is sometimes called a shell, coating, or membrane. Microparticles or pressure sensitive capsules or microcapsules are examples of this technology. Microcapsules of the current invention are formed by a variety of procedures that include, but are not limited to, coating, extrusion, spray-drying, interfacial, in-situ and matrix polymerization. The possible shell materials vary widely in their stability toward water. Among the most stable are polyoxymethyleneurea (PMU)-based materials, which may hold certain PRMs for even long periods of time in aqueous solution (or product). Such systems include but are not limited to urea-formaldehyde and/or melamine-formaldehyde. Gelatin-based microcapsules may be prepared so that they dissolve quickly or slowly in water, depending for example on the degree of cross-linking. Many other capsule wall materials are available and vary in the degree of perfume diffusion stability observed. Without wishing to be bound by theory, the rate of release of perfume from a capsule, for example, once deposited on a surface is typically in reverse order of in-product perfume diffusion stability. As such, urea-formaldehyde and melamine-formaldehyde microcapsules for example, typically require a release mechanism other than, or in addition to, diffusion for release, such as mechanical force (e.g., friction, pressure, shear stress) that serves to break the capsule and increase the rate of perfume (fragrance) release. Other triggers include melting, dissolution, hydrolysis or other chemical reaction, electromagnetic radiation, and the like. Suitable capsule wall materials include, in addition to aminoplasts, polyvinyl alcohol, polyvinyl pyrrolidone, polyethylene glycol, polysaccharides and modified polysaccharides, gel forming proteins, modified celluloses such as carboxymethylcelluloses and hydroxyethylcelluloses, polyacrylates, polyureas, polyurethanes and mixtures thereof. The capsules may be further coated with an additional coating that can improve the deposition and/or retention of the capsule on the desired surface. Suitable coating materials include a cationic polymer selected from the group consisting of selected from the group consisting of poly saccharides, cationically modified starch, cationically modified guar, polysiloxanes, poly diallyl dimethyl ammonium halides, copolymers of poly diallyl dimethyl ammonium chloride and vinyl pyrrolidone, acrylamides, imidazoles, imidazolinium halides, imidazolium halides, poly vinyl amine, copolymers of poly vinyl amine and N-vinyl formamide to the surface of the capsule to form a cationically coated polymer encapsulated material. Typical capsules have a diameter of 1 micron to 500 microns. The use of pre-loaded microcapsules requires the proper ratio of in-product stability and in-use and/or on-surface (on-situs) release, as well as proper selection of PRMs. Microcapsules that are based on urea-formaldehyde and/or melamine-formaldehyde are relatively stable, especially in near neutral aqueous-based solutions. These materials may require a friction trigger which may not be applicable to all product applications. Other microcapsule materials (e.g., gelatin) may be unstable in aqueous-based products and may even provide reduced benefit (versus free perfume control) when in-product aged."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.45, "construct": {"method_text_verbatim": "a.) Matrix Systems: The fragrance is dissolved or dispersed in a polymer matrix or particle. Perfumes, for example, may be 1) dispersed into the polymer prior to formulating into the product or 2) added separately from the polymer during or after formulation of the product. Diffusion of perfume from the polymer is a common trigger that allows or increases the rate of perfume release from a polymeric matrix system that is deposited or applied to the desired surface (situs), although many other triggers are know that may control perfume release. Absorption and/or adsorption into or onto polymeric particles, films, solutions, and the like are aspects of this technology. Nano- or micro-particles composed of organic materials (e.g., latexes) are examples. Suitable particles include a wide range of materials including, but not limited to polyacetal, polyacrylate, polyacrylic, polyacrylonitrile, polyamide, polyaryletherketone, polybutadiene, polybutylene, polybutylene terephthalate, polychlor", "panel_size": null, "property_name": "odor_intensity", "scale": "numeric_unknown", "substrate": null, "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "2005/0003980; 2004/0110648; 2006/003913", "patent_id": "US20210177721A1", "provenance": {"citation": "US20210177721A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20210177721A1/en"}, "pub_date": "2021-03-01", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:0232", "units": "ordinal_ratio", "verbatim_quote": "a.) Matrix Systems: The fragrance is dissolved or dispersed in a polymer matrix or particle. Perfumes, for example, may be 1) dispersed into the polymer prior to formulating into the product or 2) added separately from the polymer during or after formulation of the product. Diffusion of perfume from the polymer is a common trigger that allows or increases the rate of perfume release from a polymeric matrix system that is deposited or applied to the desired surface (situs), although many other triggers are know that may control perfume release. Absorption and/or adsorption into or onto polymeric particles, films, solutions, and the like are aspects of this technology. Nano- or micro-particles composed of organic materials (e.g., latexes) are examples. Suitable particles include a wide range of materials including, but not limited to polyacetal, polyacrylate, polyacrylic, polyacrylonitrile, polyamide, polyaryletherketone, polybutadiene, polybutylene, polybutylene terephthalate, polychloroprene, poly ethylene, polyethylene terephthalate, polycyclohexylene dimethylene terephthalate, polycarbonate, polychloroprene, polyhydroxyalkanoate, polyketone, polyester, polyethylene, polyetherimide, polyethersulfone, polyethylenechlorinates, polyimide, polyisoprene, polylactic acid, polymethylpentene, polyphenylene oxide, polyphenylene sulfide, polyphthalamide, polypropylene, polystyrene, polysulfone, polyvinyl acetate, polyvinyl chloride, as well as polymers or copolymers based on acrylonitrile-butadiene, cellulose acetate, ethylene-vinyl acetate, ethylene vinyl alcohol, styrene-butadiene, vinyl acetate-ethylene, and mixtures thereof. \u201cStandard\u201d systems refer to those that are \u201cpre-loaded\u201d with the intent of keeping the pre-loaded perfume associated with the polymer until the moment or moments of perfume release. Such polymers may also suppress the neat product odor and provide a bloom and/or longevity benefit depending on the rate of perfume release. One challenge with such systems is to achieve the ideal balance between 1) in-product stability (keeping perfume inside carrier until you need it) and 2) timely release (during use or from dry situs). Achieving such stability is particularly important during in-product storage and product aging. This challenge is particularly apparent for aqueous-based, surfactant-containing products, such as heavy duty liquid laundry detergents. Many \u201cStandard\u201d matrix systems available effectively become \u201cEquilibrium\u201d systems when formulated into aqueous-based products. One may select an \u201cEquilibrium\u201d system or a Reservoir system, which has acceptable in-product diffusion stability and available triggers for release (e.g., friction). \u201cEquilibrium\u201d systems are those in which the perfume and polymer may be added separately to the product, and the equilibrium interaction between perfume and polymer leads to a benefit at one or more consumer touch points (versus a free perfume control that has no polymer-assisted delivery technology). The polymer may also be pre-loaded with perfume; however, part or all of the perfume may diffuse during in-product storage reaching an equilibrium that includes having desired perfume raw materials (PRMs) associated with the polymer. The polymer then carries the perfume to the surface, and release is typically via perfume diffusion. The use of such equilibrium system polymers has the potential to decrease the neat product odor intensity of the neat product (usually more so in the case of pre-loaded standard system). Deposition of such polymers may serve to \u201cflatten\u201d the release profile and provide increased longevity. As indicated above, such longevity would be achieved by suppressing the initial intensity and may enable the formulator to use more high impact or low odor detection threshold (ODT) or low Kovats Index (KI) PRMs to achieve FMOT benefits without initial intensity that is too strong or distorted. It is important that perfume release occurs within the time frame of the application to impact the desired consumer touch point or touch points. Suitable micro-particles and micro-latexes as well as methods of making same may be found in USPA 2005/0003980 A1. Matrix systems also include hot melt adhesives and perfume plastics. In addition, hydrophobically modified polysaccharides may be formulated into the perfumed product to increase perfume deposition and/or modify perfume release. All such matrix systems, including for example polysaccharides and nanolatexes may be combined with other PDTs, including other PAD systems such as PAD reservoir systems in the form of a perfume microcapsule (PMC). Polymer Assisted Delivery (PAD) matrix systems may include those described in the following references: US Patent Application 2004/0110648 A1 and U.S. Pat. No. 6,531,444. Silicones are also examples of polymers that may be used as PDT, and can provide perfume benefits in a manner similar to the polymer-assisted delivery \u201cmatrix system\u201d. Such a PDT is referred to as silicone-assisted delivery (SAD). One may pre-load silicones with perfume, or use them as an equilibrium system as described for PAD. Suitable silicones as well as making same may be found in USPA 20050143282A1. Functionalized silicones may also be used as described in USPA 2006/003913 A1. Examples of silicones include polydimethylsiloxane and polyalkyldimethylsiloxanes. Other examples include those with amine functionality, which may be used to provide benefits associated with amine-assisted delivery (AAD) and/or polymer-assisted delivery (PAD) and/or amine-reaction products (ARP). Other such examples may be found in USPA 2005/0003980 A1."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.45, "construct": {"method_text_verbatim": "\u201cStandard\u201d systems refer to those that are \u201cpre-loaded\u201d with the intent of keeping the pre-loaded perfume associated with the polymer until the moment or moments of perfume release. Such polymers may also suppress the neat product odor and provide a bloom and/or longevity benefit depending on the rate of perfume release. One challenge with such systems is to achieve the ideal balance between 1) in-product stability (keeping perfume inside carrier until you need it) and 2) timely release (during use or from dry situs). Achieving such stability is particularly important during in-product storage and product aging. This challenge is particularly apparent for aqueous-based, surfactant-containing products, such as heavy duty liquid laundry detergents. Many \u201cStandard\u201d matrix systems available effectively become \u201cEquilibrium\u201d systems when formulated into aqueous-based products. One may select an \u201cEquilibrium\u201d system or a Reservoir system, which has acceptable in-product diffusion stability an", "panel_size": null, "property_name": "odor_intensity", "scale": "numeric_unknown", "substrate": null, "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "2005/0003980; 2004/0110648", "patent_id": "US20210177721A1", "provenance": {"citation": "US20210177721A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20210177721A1/en"}, "pub_date": "2021-03-01", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:0233", "units": "ordinal_ratio", "verbatim_quote": "\u201cStandard\u201d systems refer to those that are \u201cpre-loaded\u201d with the intent of keeping the pre-loaded perfume associated with the polymer until the moment or moments of perfume release. Such polymers may also suppress the neat product odor and provide a bloom and/or longevity benefit depending on the rate of perfume release. One challenge with such systems is to achieve the ideal balance between 1) in-product stability (keeping perfume inside carrier until you need it) and 2) timely release (during use or from dry situs). Achieving such stability is particularly important during in-product storage and product aging. This challenge is particularly apparent for aqueous-based, surfactant-containing products, such as heavy duty liquid laundry detergents. Many \u201cStandard\u201d matrix systems available effectively become \u201cEquilibrium\u201d systems when formulated into aqueous-based products. One may select an \u201cEquilibrium\u201d system or a Reservoir system, which has acceptable in-product diffusion stability and available triggers for release (e.g., friction). \u201cEquilibrium\u201d systems are those in which the perfume and polymer may be added separately to the product, and the equilibrium interaction between perfume and polymer leads to a benefit at one or more consumer touch points (versus a free perfume control that has no polymer-assisted delivery technology). The polymer may also be pre-loaded with perfume; however, part or all of the perfume may diffuse during in-product storage reaching an equilibrium that includes having desired perfume raw materials (PRMs) associated with the polymer. The polymer then carries the perfume to the surface, and release is typically via perfume diffusion. The use of such equilibrium system polymers has the potential to decrease the neat product odor intensity of the neat product (usually more so in the case of pre-loaded standard system). Deposition of such polymers may serve to \u201cflatten\u201d the release profile and provide increased longevity. As indicated above, such longevity would be achieved by suppressing the initial intensity and may enable the formulator to use more high impact or low odor detection threshold (ODT) or low Kovats Index (KI) PRMs to achieve FMOT benefits without initial intensity that is too strong or distorted. It is important that perfume release occurs within the time frame of the application to impact the desired consumer touch point or touch points. Suitable micro-particles and micro-latexes as well as methods of making same may be found in USPA 2005/0003980 A1. Matrix systems also include hot melt adhesives and perfume plastics. In addition, hydrophobically modified polysaccharides may be formulated into the perfumed product to increase perfume deposition and/or modify perfume release. All such matrix systems, including for example polysaccharides and nanolatexes may be combined with other PDTs, including other PAD systems such as PAD reservoir systems in the form of a perfume microcapsule (PMC). Polymer Assisted Delivery (PAD) matrix systems may include those described in the following references: US Patent Application 2004/0110648 A1 and U.S. Pat. No. 6,531,444."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.45, "construct": {"method_text_verbatim": "VIII. Pro-Perfume (PP): This technology refers to perfume technologies that result from the reaction of perfume materials with other substrates or chemicals to form materials that have a covalent bond between one or more PRMs and one or more carriers. The PRM is converted into a new material called a pro-PRM (i.e., pro-perfume), which then may release the original PRM upon exposure to a trigger such as water or light. Pro-perfumes may provide enhanced perfume delivery properties such as increased perfume deposition, longevity, stability, retention, and the like. Pro-perfumes include those that are monomeric (non-polymeric) or polymeric, and may b e pre-formed or may be formed in-situ under equilibrium conditions, such as those that may be present during in-product storage or on the wet or dry situs. Nonlimiting examples of pro-perfumes include Michael adducts (e.g., beta-amino ketones), aromatic or non-aromatic imines (Schiffs Bases), oxazolidines, beta-keto esters, and orthoesters. An", "panel_size": null, "property_name": "longevity", "scale": "numeric_unknown", "substrate": null, "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "2006/0020459", "patent_id": "US20210177721A1", "provenance": {"citation": "US20210177721A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20210177721A1/en"}, "pub_date": "2021-03-01", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:338", "units": "ordinal_ratio", "verbatim_quote": "VIII. Pro-Perfume (PP): This technology refers to perfume technologies that result from the reaction of perfume materials with other substrates or chemicals to form materials that have a covalent bond between one or more PRMs and one or more carriers. The PRM is converted into a new material called a pro-PRM (i.e., pro-perfume), which then may release the original PRM upon exposure to a trigger such as water or light. Pro-perfumes may provide enhanced perfume delivery properties such as increased perfume deposition, longevity, stability, retention, and the like. Pro-perfumes include those that are monomeric (non-polymeric) or polymeric, and may b e pre-formed or may be formed in-situ under equilibrium conditions, such as those that may be present during in-product storage or on the wet or dry situs. Nonlimiting examples of pro-perfumes include Michael adducts (e.g., beta-amino ketones), aromatic or non-aromatic imines (Schiffs Bases), oxazolidines, beta-keto esters, and orthoesters. Another aspect includes compounds comprising one or more beta-oxy or beta-thio carbonyl moieties capable of releasing a PRM, for example, an alpha, beta-unsaturated ketone, aldehyde or carboxylic ester. The typical trigger for perfume release is exposure to water; although other triggers may include enzymes, heat, light, pH change, autoxidation, a shift of equilibrium, change in concentration or ionic strength and others. For aqueous-based products, light-triggered pro-perfumes are particularly suited. Such photo-pro-perfumes (PPPs) include but are not limited to those that release coumarin derivatives and perfumes and/or pro-perfumes upon being triggered. The released pro-perfume may release one or more PRMs by means of any of the above mentioned triggers. In one aspect, the photo-pro-perfume releases a nitrogen-based pro-perfume when exposed to a light and/or moisture trigger. In another aspect, the nitrogen-based pro-perfume, released from the photo-pro-perfume, releases one or more PRMs selected, for example, from aldehydes, ketones (including enones) and alcohols. In still another aspect, the PPP releases a dihydroxy coumarin derivative. The light-triggered pro-perfume may also be an ester that releases a coumarin derivative and a perfume alcohol. In one aspect the pro-perfume is a dimethoxybenzoin derivative as described in USPA 2006/0020459 A1. In another aspect the pro-perfume is a 3\u2032,5\u2032-dimethoxybenzoin (DMB) derivative that releases an alcohol upon exposure to electromagnetic radiation. In yet another aspect, the pro-perfume releases one or more low ODT PRMs, including tertiary alcohols such as linalool, tetrahydrolinalool, or dihydromyrcenol. Suitable pro-perfumes and methods of making same can be found in U.S. Pat. No. 7,018,978 B2."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Symrise AG", "compound_ref_verbatim": null, "confidence": 0.6, "construct": {"method_text_verbatim": "The odor intensity is assessed at the following time intervals after dipping of the smelling strips: 1 hour or less (shown in FIG. 1 as time point \u201c0 days\u201d); 1 day; 2 days; 3 days; 4 days; 7 days; 8 days; 9 days. To ensure that the testers are not influenced, the coded smelling strips are not arranged in a chronological order on the smelling strip stand.", "panel_size": null, "property_name": "odor_intensity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["1 hour", "0 days", "1 day", "2 days", "3 days", "4 days", "7 days", "8 days", "9 days"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "1 hour; 0 days; 1 day; 2 days; 3 days; 4 days; 7 days; 8 days; 9 days", "patent_id": "US20240084216A1", "provenance": {"citation": "US20240084216A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20240084216A1/en"}, "pub_date": "2023-08-09", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:1346", "units": "hours", "verbatim_quote": "The odor intensity is assessed at the following time intervals after dipping of the smelling strips: 1 hour or less (shown in FIG. 1 as time point \u201c0 days\u201d); 1 day; 2 days; 3 days; 4 days; 7 days; 8 days; 9 days. To ensure that the testers are not influenced, the coded smelling strips are not arranged in a chronological order on the smelling strip stand."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Symrise AG", "compound_ref_verbatim": null, "confidence": 0.6, "construct": {"method_text_verbatim": "The odor intensity of the compound of formula (Ia) (black filled bar) is assessed in the fresh state and for a period of up to 3 days by the testers in comparison with Lilial\u00ae (black cross-hatched bar) as stronger, and after 4 to 7 days at least comparable to Lilial\u00ae. After 9 days, a higher odor intensity of the compound of formula (Ia) compared to Lilial\u00ae is observed again.", "panel_size": null, "property_name": "odor_intensity", "scale": "numeric_unknown", "substrate": null, "time_points": ["3 days", "7 days", "9 days"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "3 days; 4 to 7; 9 days", "patent_id": "US20240084216A1", "provenance": {"citation": "US20240084216A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20240084216A1/en"}, "pub_date": "2023-08-09", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:1347", "units": "days", "verbatim_quote": "The odor intensity of the compound of formula (Ia) (black filled bar) is assessed in the fresh state and for a period of up to 3 days by the testers in comparison with Lilial\u00ae (black cross-hatched bar) as stronger, and after 4 to 7 days at least comparable to Lilial\u00ae. After 9 days, a higher odor intensity of the compound of formula (Ia) compared to Lilial\u00ae is observed again."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Symrise AG", "compound_ref_verbatim": null, "confidence": 0.6, "construct": {"method_text_verbatim": "The odor intensity of compound (Ib) (black dotted bar) is, in the fresh state, stronger than that of Lilial\u00ae (black cross-hatched bar) and after one day is comparable to Lilial\u00ae. After that, the odor intensity of the compound of formula (Ib) at first decreases more than for Lilial\u00ae and the compound of formula (Ia), but after 7 to 9 days the values are comparable or slightly higher than with Lilial\u00ae.", "panel_size": null, "property_name": "odor_intensity", "scale": "numeric_unknown", "substrate": null, "time_points": ["9 days"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "7 to 9", "patent_id": "US20240084216A1", "provenance": {"citation": "US20240084216A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20240084216A1/en"}, "pub_date": "2023-08-09", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:1348", "units": null, "verbatim_quote": "The odor intensity of compound (Ib) (black dotted bar) is, in the fresh state, stronger than that of Lilial\u00ae (black cross-hatched bar) and after one day is comparable to Lilial\u00ae. After that, the odor intensity of the compound of formula (Ib) at first decreases more than for Lilial\u00ae and the compound of formula (Ia), but after 7 to 9 days the values are comparable or slightly higher than with Lilial\u00ae."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.45, "construct": {"method_text_verbatim": "a.) Matrix Systems: The fragrance is dissolved or dispersed in a polymer matrix or particle. Perfumes, for example, may be 1) dispersed into the polymer prior to formulating into the product or 2) added separately from the polymer during or after formulation of the product. Diffusion of perfume from the polymer is a common trigger that allows or increases the rate of perfume release from a polymeric matrix system that is deposited or applied to the desired surface (situs), although many other triggers are know that may control perfume release. Absorption and/or adsorption into or onto polymeric particles, films, solutions, and the like are aspects of this technology. Nano- or micro-particles composed of organic materials (e.g., latexes) are examples. Suitable particles include a wide range of materials including, but not limited to polyacetal, polyacrylate, polyacrylic, polyacrylonitrile, polyamide, polyaryletherketone, polybutadiene, polybutylene, polybutylene terephthalate, polychlor", "panel_size": null, "property_name": "odor_intensity", "scale": "numeric_unknown", "substrate": null, "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "2005/0003980; 2004/0110648; 2004/0092414; 2004/0091445; 2004/0087476; 2005/102261; 2003/015736; 2006/003913; 2004/0058845; 2004/0092425; 2003/0125222; 2003/215417; 2003/216488; 2003/158344; 2003/165692; 2004/071742; 2004/071746; 2004/072719; 2004/072720; 2006/0039934; 2003/203829; 2003/195133; 2004/087477; 2004/0106536", "patent_id": "US9994793B2", "provenance": {"citation": "US9994793B2", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US9994793B2/en"}, "pub_date": "2016-07-21", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:0000", "units": "ordinal_ratio", "verbatim_quote": "a.) Matrix Systems: The fragrance is dissolved or dispersed in a polymer matrix or particle. Perfumes, for example, may be 1) dispersed into the polymer prior to formulating into the product or 2) added separately from the polymer during or after formulation of the product. Diffusion of perfume from the polymer is a common trigger that allows or increases the rate of perfume release from a polymeric matrix system that is deposited or applied to the desired surface (situs), although many other triggers are know that may control perfume release. Absorption and/or adsorption into or onto polymeric particles, films, solutions, and the like are aspects of this technology. Nano- or micro-particles composed of organic materials (e.g., latexes) are examples. Suitable particles include a wide range of materials including, but not limited to polyacetal, polyacrylate, polyacrylic, polyacrylonitrile, polyamide, polyaryletherketone, polybutadiene, polybutylene, polybutylene terephthalate, polychloroprene, poly ethylene, polyethylene terephthalate, polycyclohexylene dimethylene terephthalate, polycarbonate, polychloroprene, polyhydroxyalkanoate, polyketone, polyester, polyethylene, polyetherimide, polyethersulfone, polyethylenechlorinates, polyimide, polyisoprene, polylactic acid, polymethylpentene, polyphenylene oxide, polyphenylene sulfide, polyphthalamide, polypropylene, polystyrene, polysulfone, polyvinyl acetate, polyvinyl chloride, as well as polymers or copolymers based on acrylonitrile-butadiene, cellulose acetate, ethylene-vinyl acetate, ethylene vinyl alcohol, styrene-butadiene, vinyl acetate-ethylene, and mixtures thereof. \u201cStandard\u201d systems refer to those that are \u201cpre-loaded\u201d with the intent of keeping the pre-loaded perfume associated with the polymer until the moment or moments of perfume release. Such polymers may also suppress the neat product odor and provide a bloom and/or longevity benefit depending on the rate of perfume release. One challenge with such systems is to achieve the ideal balance between 1) in-product stability (keeping perfume inside carrier until you need it) and 2) timely release (during use or from dry situs). Achieving such stability is particularly important during in-product storage and product aging. This challenge is particularly apparent for aqueous-based, surfactant-containing products, such as heavy duty liquid laundry detergents. Many \u201cStandard\u201d matrix systems available effectively become \u201cEquilibrium\u201d systems when formulated into aqueous-based products. One may select an \u201cEquilibrium\u201d system or a Reservoir system, which has acceptable in-product diffusion stability and available triggers for release (e.g., friction). \u201cEquilibrium\u201d systems are those in which the perfume and polymer may be added separately to the product, and the equilibrium interaction between perfume and polymer leads to a benefit at one or more consumer touch points (versus a free perfume control that has no polymer-assisted delivery technology). The polymer may also be pre-loaded with perfume; however, part or all of the perfume may diffuse during in-product storage reaching an equilibrium that includes having desired perfume raw materials (PRMs) associated with the polymer. The polymer then carries the perfume to the surface, and release is typically via perfume diffusion. The use of such equilibrium system polymers has the potential to decrease the neat product odor intensity of the neat product (usually more so in the case of pre-loaded standard system). Deposition of such polymers may serve to \u201cflatten\u201d the release profile and provide increased longevity. As indicated above, such longevity would be achieved by suppressing the initial intensity and may enable the formulator to use more high impact or low odor detection threshold (ODT) or low Kovats Index (KI) PRMs to achieve FMOT benefits without initial intensity that is too strong or distorted. It is important that perfume release occurs within the time frame of the application to impact the desired consumer touch point or touch points. Suitable micro-particles and micro-latexes as well as methods of making same may be found in USPA 2005/0003980 A1. Matrix systems also include hot melt adhesives and perfume plastics. In addition, hydrophobically modified polysaccharides may be formulated into the perfumed product to increase perfume deposition and/or modify perfume release. All such matrix systems, including for example polysaccarides and nanolatexes may be combined with other PDTs, including other PAD systems such as PAD reservoir systems in the form of a perfume microcapsule (PMC). Polymer Assisted Delivery (PAD) matrix systems may include those described in the following references: US Patent Applications 2004/0110648 A1; 2004/0092414 A1; 2004/0091445 A1 and 2004/0087476 A1; and U.S. Pat. Nos. 6,531,444; 6,024,943; 6,042,792; 6,051,540; 4,540,721 and 4,973,422. Silicones are also examples of polymers that may be used as PDT, and can provide perfume benefits in a manner similar to the polymer-assisted delivery \u201cmatrix system\u201d. Such a PDT is referred to as silicone-assisted delivery (SAD). One may pre-load silicones with perfume, or use them as an equilibrium system as described for PAD. Suitable silicones as well as making same may be found in WO 2005/102261; USPA 20050124530A1; USPA 20050143282A1; and WO 2003/015736. Functionalized silicones may also be used as described in USPA 2006/003913 A1. Examples of silicones include polydimethylsiloxane and polyalkyldimethylsiloxanes. Other examples include those with amine functionality, which may be used to provide benefits associated with amine-assisted delivery (AAD) and/or polymer-assisted delivery (PAD) and/or amine-reaction products (ARP). Other such examples may be found in U.S. Pat. No. 4,911,852; USPA 2004/0058845 A1; USPA 2004/0092425 A1 and USPA 2005/0003980 A1. b.) Reservoir Systems: Reservoir systems are also known as a core-shell type technology, or one in which the fragrance is surrounded by a perfume release controlling membrane, which may serve as a protective shell. The material inside the microcapsule is referred to as the core, internal phase, or fill, whereas the wall is sometimes called a shell, coating, or membrane. Microparticles or pressure sensitive capsules or microcapsules are examples of this technology. Microcapsules of the current invention are formed by a variety of procedures that include, but are not limited to, coating, extrusion, spray-drying, interfacial, in-situ and matrix polymerization. The possible shell materials vary widely in their stability toward water. Among the most stable are polyoxymethyleneurea (PMU)-based materials, which may hold certain PRMs for even long periods of time in aqueous solution (or product). Such systems include but are not limited to urea-formaldehyde and/or melamine-formaldehyde. Gelatin-based microcapsules may be prepared so that they dissolve quickly or slowly in water, depending for example on the degree of cross-linking. Many other capsule wall materials are available and vary in the degree of perfume diffusion stability observed. Without wishing to be bound by theory, the rate of release of perfume from a capsule, for example, once deposited on a surface is typically in reverse order of in-product perfume diffusion stability. As such, urea-formaldehyde and melamine-formaldehyde microcapsules for example, typically require a release mechanism other than, or in addition to, diffusion for release, such as mechanical force (e.g., friction, pressure, shear stress) that serves to break the capsule and increase the rate of perfume (fragrance) release. Other triggers include melting, dissolution, hydrolysis or other chemical reaction, electromagnetic radiation, and the like. The use of pre-loaded microcapsules requires the proper ratio of in-product stability and in-use and/or on-surface (on-situs) release, as well as proper selection of PRMs. Microcapsules that are based on urea-formaldehyde and/or melamine-formaldehyde are relatively stable, especially in near neutral aqueous-based solutions. These materials may require a friction trigger which may not be applicable to all product applications. Other microcapsule materials (e.g., gelatin) may be unstable in aqueous-based products and may even provide reduced benefit (versus free perfume control) when in-product aged. Scratch and sniff technologies are yet another example of PAD. Perfume microcapsules (PMC) may include those described in the following references: US Patent Applications: 2003/0125222 A1; 2003/215417 A1; 2003/216488 A1; 2003/158344 A1; 2003/165692 A1; 2004/071742 A1; 2004/071746 A1; 2004/072719 A1; 2004/072720 A1; 2006/0039934 A1; 2003/203829 A1; 2003/195133 A1; 2004/087477 A1; 2004/0106536 A1; and U.S. Pat. Nos. 6,645,479 B1; 6,200,949 B1; 4,882,220; 4,917,920; 4,514,461; 6,106,875 and U.S. Pat. Nos. 4,234,627, 3,594,328 and US RE 32713. II. Molecule-Assisted Delivery (MAD):"}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.45, "construct": {"method_text_verbatim": "a.) Matrix Systems: The fragrance is dissolved or dispersed in a polymer matrix or particle. Perfumes, for example, may be 1) dispersed into the polymer prior to formulating into the product or 2) added separately from the polymer during or after formulation of the product. Diffusion of perfume from the polymer is a common trigger that allows or increases the rate of perfume release from a polymeric matrix system that is deposited or applied to the desired surface (situs), although many other triggers are know that may control perfume release. Absorption and/or adsorption into or onto polymeric particles, films, solutions, and the like are aspects of this technology. Nano- or micro-particles composed of organic materials (e.g., latexes) are examples. Suitable particles include a wide range of materials including, but not limited to polyacetal, polyacrylate, polyacrylic, polyacrylonitrile, polyamide, polyaryletherketone, polybutadiene, polybutylene, polybutylene terephthalate, polychlor", "panel_size": null, "property_name": "odor_intensity", "scale": "numeric_unknown", "substrate": null, "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "2005/0003980; 2004/0110648; 2004/0092414; 2004/0091445; 2004/0087476; 2005/102261; 2003/015736; 2006/003913; 2004/0058845; 2004/0092425", "patent_id": "US9994793B2", "provenance": {"citation": "US9994793B2", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US9994793B2/en"}, "pub_date": "2016-07-21", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:0116", "units": "ordinal_ratio", "verbatim_quote": "a.) Matrix Systems: The fragrance is dissolved or dispersed in a polymer matrix or particle. Perfumes, for example, may be 1) dispersed into the polymer prior to formulating into the product or 2) added separately from the polymer during or after formulation of the product. Diffusion of perfume from the polymer is a common trigger that allows or increases the rate of perfume release from a polymeric matrix system that is deposited or applied to the desired surface (situs), although many other triggers are know that may control perfume release. Absorption and/or adsorption into or onto polymeric particles, films, solutions, and the like are aspects of this technology. Nano- or micro-particles composed of organic materials (e.g., latexes) are examples. Suitable particles include a wide range of materials including, but not limited to polyacetal, polyacrylate, polyacrylic, polyacrylonitrile, polyamide, polyaryletherketone, polybutadiene, polybutylene, polybutylene terephthalate, polychloroprene, poly ethylene, polyethylene terephthalate, polycyclohexylene dimethylene terephthalate, polycarbonate, polychloroprene, polyhydroxyalkanoate, polyketone, polyester, polyethylene, polyetherimide, polyethersulfone, polyethylenechlorinates, polyimide, polyisoprene, polylactic acid, polymethylpentene, polyphenylene oxide, polyphenylene sulfide, polyphthalamide, polypropylene, polystyrene, polysulfone, polyvinyl acetate, polyvinyl chloride, as well as polymers or copolymers based on acrylonitrile-butadiene, cellulose acetate, ethylene-vinyl acetate, ethylene vinyl alcohol, styrene-butadiene, vinyl acetate-ethylene, and mixtures thereof. \u201cStandard\u201d systems refer to those that are \u201cpre-loaded\u201d with the intent of keeping the pre-loaded perfume associated with the polymer until the moment or moments of perfume release. Such polymers may also suppress the neat product odor and provide a bloom and/or longevity benefit depending on the rate of perfume release. One challenge with such systems is to achieve the ideal balance between 1) in-product stability (keeping perfume inside carrier until you need it) and 2) timely release (during use or from dry situs). Achieving such stability is particularly important during in-product storage and product aging. This challenge is particularly apparent for aqueous-based, surfactant-containing products, such as heavy duty liquid laundry detergents. Many \u201cStandard\u201d matrix systems available effectively become \u201cEquilibrium\u201d systems when formulated into aqueous-based products. One may select an \u201cEquilibrium\u201d system or a Reservoir system, which has acceptable in-product diffusion stability and available triggers for release (e.g., friction). \u201cEquilibrium\u201d systems are those in which the perfume and polymer may be added separately to the product, and the equilibrium interaction between perfume and polymer leads to a benefit at one or more consumer touch points (versus a free perfume control that has no polymer-assisted delivery technology). The polymer may also be pre-loaded with perfume; however, part or all of the perfume may diffuse during in-product storage reaching an equilibrium that includes having desired perfume raw materials (PRMs) associated with the polymer. The polymer then carries the perfume to the surface, and release is typically via perfume diffusion. The use of such equilibrium system polymers has the potential to decrease the neat product odor intensity of the neat product (usually more so in the case of pre-loaded standard system). Deposition of such polymers may serve to \u201cflatten\u201d the release profile and provide increased longevity. As indicated above, such longevity would be achieved by suppressing the initial intensity and may enable the formulator to use more high impact or low odor detection threshold (ODT) or low Kovats Index (KI) PRMs to achieve FMOT benefits without initial intensity that is too strong or distorted. It is important that perfume release occurs within the time frame of the application to impact the desired consumer touch point or touch points. Suitable micro-particles and micro-latexes as well as methods of making same may be found in USPA 2005/0003980 A1. Matrix systems also include hot melt adhesives and perfume plastics. In addition, hydrophobically modified polysaccharides may be formulated into the perfumed product to increase perfume deposition and/or modify perfume release. All such matrix systems, including for example polysaccarides and nanolatexes may be combined with other PDTs, including other PAD systems such as PAD reservoir systems in the form of a perfume microcapsule (PMC). Polymer Assisted Delivery (PAD) matrix systems may include those described in the following references: US Patent Applications 2004/0110648 A1; 2004/0092414 A1; 2004/0091445 A1 and 2004/0087476 A1; and U.S. Pat. Nos. 6,531,444; 6,024,943; 6,042,792; 6,051,540; 4,540,721 and 4,973,422. Silicones are also examples of polymers that may be used as PDT, and can provide perfume benefits in a manner similar to the polymer-assisted delivery \u201cmatrix system\u201d. Such a PDT is referred to as silicone-assisted delivery (SAD). One may pre-load silicones with perfume, or use them as an equilibrium system as described for PAD. Suitable silicones as well as making same may be found in WO 2005/102261; USPA 20050124530A1; USPA 20050143282A1; and WO 2003/015736. Functionalized silicones may also be used as described in USPA 2006/003913 A1. Examples of silicones include polydimethylsiloxane and polyalkyldimethylsiloxanes. Other examples include those with amine functionality, which may be used to provide benefits associated with amine-assisted delivery (AAD) and/or polymer-assisted delivery (PAD) and/or amine-reaction products (ARP). Other such examples may be found in U.S. Pat. No. 4,911,852; USPA 2004/0058845 A1; USPA 2004/0092425 A1 and USPA 2005/0003980 A1."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.45, "construct": {"method_text_verbatim": "\u201cStandard\u201d systems refer to those that are \u201cpre-loaded\u201d with the intent of keeping the pre-loaded perfume associated with the polymer until the moment or moments of perfume release. Such polymers may also suppress the neat product odor and provide a bloom and/or longevity benefit depending on the rate of perfume release. One challenge with such systems is to achieve the ideal balance between 1) in-product stability (keeping perfume inside carrier until you need it) and 2) timely release (during use or from dry situs). Achieving such stability is particularly important during in-product storage and product aging. This challenge is particularly apparent for aqueous-based, surfactant-containing products, such as heavy duty liquid laundry detergents. Many \u201cStandard\u201d matrix systems available effectively become \u201cEquilibrium\u201d systems when formulated into aqueous-based products. One may select an \u201cEquilibrium\u201d system or a Reservoir system, which has acceptable in-product diffusion stability an", "panel_size": null, "property_name": "odor_intensity", "scale": "numeric_unknown", "substrate": null, "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "2005/0003980; 2004/0110648; 2004/0092414; 2004/0091445; 2004/0087476", "patent_id": "US9994793B2", "provenance": {"citation": "US9994793B2", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US9994793B2/en"}, "pub_date": "2016-07-21", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:0117", "units": "ordinal_ratio", "verbatim_quote": "\u201cStandard\u201d systems refer to those that are \u201cpre-loaded\u201d with the intent of keeping the pre-loaded perfume associated with the polymer until the moment or moments of perfume release. Such polymers may also suppress the neat product odor and provide a bloom and/or longevity benefit depending on the rate of perfume release. One challenge with such systems is to achieve the ideal balance between 1) in-product stability (keeping perfume inside carrier until you need it) and 2) timely release (during use or from dry situs). Achieving such stability is particularly important during in-product storage and product aging. This challenge is particularly apparent for aqueous-based, surfactant-containing products, such as heavy duty liquid laundry detergents. Many \u201cStandard\u201d matrix systems available effectively become \u201cEquilibrium\u201d systems when formulated into aqueous-based products. One may select an \u201cEquilibrium\u201d system or a Reservoir system, which has acceptable in-product diffusion stability and available triggers for release (e.g., friction). \u201cEquilibrium\u201d systems are those in which the perfume and polymer may be added separately to the product, and the equilibrium interaction between perfume and polymer leads to a benefit at one or more consumer touch points (versus a free perfume control that has no polymer-assisted delivery technology). The polymer may also be pre-loaded with perfume; however, part or all of the perfume may diffuse during in-product storage reaching an equilibrium that includes having desired perfume raw materials (PRMs) associated with the polymer. The polymer then carries the perfume to the surface, and release is typically via perfume diffusion. The use of such equilibrium system polymers has the potential to decrease the neat product odor intensity of the neat product (usually more so in the case of pre-loaded standard system). Deposition of such polymers may serve to \u201cflatten\u201d the release profile and provide increased longevity. As indicated above, such longevity would be achieved by suppressing the initial intensity and may enable the formulator to use more high impact or low odor detection threshold (ODT) or low Kovats Index (KI) PRMs to achieve FMOT benefits without initial intensity that is too strong or distorted. It is important that perfume release occurs within the time frame of the application to impact the desired consumer touch point or touch points. Suitable micro-particles and micro-latexes as well as methods of making same may be found in USPA 2005/0003980 A1. Matrix systems also include hot melt adhesives and perfume plastics. In addition, hydrophobically modified polysaccharides may be formulated into the perfumed product to increase perfume deposition and/or modify perfume release. All such matrix systems, including for example polysaccarides and nanolatexes may be combined with other PDTs, including other PAD systems such as PAD reservoir systems in the form of a perfume microcapsule (PMC). Polymer Assisted Delivery (PAD) matrix systems may include those described in the following references: US Patent Applications 2004/0110648 A1; 2004/0092414 A1; 2004/0091445 A1 and 2004/0087476 A1; and U.S. Pat. Nos. 6,531,444; 6,024,943; 6,042,792; 6,051,540; 4,540,721 and 4,973,422."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.75, "construct": {"method_text_verbatim": "1. 20 ml headspace vial 2. Timer. 3. Gas Chromatograph (GC): Agilent model 6890 with a CIS-4 injector (Gerstel, Mulheim, Germany) and MPS-2 Autosampler and TDU. For SPME analysis, we used the split/splitless injector (not the CIS-4 injector). 4. GC column: J&W DB-5 MS, 30 M\u00d70.25 mm ID, 1.0 m film thickness obtained from J&W Scientific of Folsom, Calif., USA. 5. Carrier gas, helium, 1.5 ml/min. flow rate. 6. The injector liner is a special SPME liner (0.75 mm ID) from Supelco. 7. The Detector is a model 5973 Mass Selective Detector obtained from Agilent Technologies, Inc., Wilmington, Del., USA having a source temperature of about 230\u00b0 C., and a MS Quad temperature of about 150\u00b0 C. Analysis Procedure: 1. Transfer sample to proper sample tray and proceed with SPME-GC-MS analysis. 2. Start sequence of sample loading and analysis. In this step, the sample is allowed to equilibrate for at least two hours on the auto sampler tray, then sampled directly from the tray. The SPME fiber assembly ", "panel_size": null, "property_name": "headspace_concentration_or_intensity", "scale": "percent", "substrate": ["headspace"], "time_points": ["5 minutes", "3 minutes", "4.67 minute"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "50/30; 5 minutes; 3 minutes; 4.67 minute", "patent_id": "US9994793B2", "provenance": {"citation": "US9994793B2", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US9994793B2/en"}, "pub_date": "2016-07-21", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:0000", "units": "ordinal_ratio", "verbatim_quote": "1. 20 ml headspace vial 2. Timer. 3. Gas Chromatograph (GC): Agilent model 6890 with a CIS-4 injector (Gerstel, Mulheim, Germany) and MPS-2 Autosampler and TDU. For SPME analysis, we used the split/splitless injector (not the CIS-4 injector). 4. GC column: J&W DB-5 MS, 30 M\u00d70.25 mm ID, 1.0 m film thickness obtained from J&W Scientific of Folsom, Calif., USA. 5. Carrier gas, helium, 1.5 ml/min. flow rate. 6. The injector liner is a special SPME liner (0.75 mm ID) from Supelco. 7. The Detector is a model 5973 Mass Selective Detector obtained from Agilent Technologies, Inc., Wilmington, Del., USA having a source temperature of about 230\u00b0 C., and a MS Quad temperature of about 150\u00b0 C. Analysis Procedure: 1. Transfer sample to proper sample tray and proceed with SPME-GC-MS analysis. 2. Start sequence of sample loading and analysis. In this step, the sample is allowed to equilibrate for at least two hours on the auto sampler tray, then sampled directly from the tray. The SPME fiber assembly is DVB/CAR/PDMS (50/30 um, 24 ga, 1 cm length). Sampling time is 5 minutes. 3. Injector temperature is at 260 C. 4. Then GC-MS analysis run is started. Desportion time is 5 minutes. 5. The following temperature program is used: i) an initial temperature of about 50\u00b0 C. which is held for 3 minutes, ii) increase the initial temperature at a rate of about 6\u00b0 C./min until a temperature of about 250\u00b0 C. is reached, then 25\u00b0 C./min to 275\u00b0 C., hold at about 275\u00b0 C. for 4.67 minute. 6. Perfume compounds are identified using the MS spectral libraries of John Wiley & Sons and the National Institute of Standards and Technology (NIST), purchased and licensed through Hewlett Packard. 7. Chromatographic peaks for specific ions are integrated using the Chemstation software obtained from Agilent Technologies, Inc., Wilmington, Del., USA. 8. The ratio for each PRM is calculated by dividing the peak area for the perfume raw material in Sample A by the peak area in Sample B. 9. Each ratio is then weighted by that perfume raw material's weight composition in the perfume. 10. The Headspace Ratio is calculated as the sum of the individual perfume raw material ratios obtained in step 9. (4) Perfume Leakage can Also be Evaluated Via % Liquid-Liquid Extraction and Gas Chromatographic-Mass Spectrometric Analysis"}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.4, "construct": {"method_text_verbatim": "2. Start sequence of sample loading and analysis. In this step, the sample is allowed to equilibrate for at least two hours on the auto sampler tray, then sampled directly from the tray. The SPME fiber assembly is DVB/CAR/PDMS (50/30 um, 24 ga, 1 cm length). Sampling time is 5 minutes.", "panel_size": null, "property_name": "unknown_numeric_measure", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["5 minutes"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "50/30; 5 minutes", "patent_id": "US9994793B2", "provenance": {"citation": "US9994793B2", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US9994793B2/en"}, "pub_date": "2016-07-21", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:0162", "units": "ordinal_ratio", "verbatim_quote": "2. Start sequence of sample loading and analysis. In this step, the sample is allowed to equilibrate for at least two hours on the auto sampler tray, then sampled directly from the tray. The SPME fiber assembly is DVB/CAR/PDMS (50/30 um, 24 ga, 1 cm length). Sampling time is 5 minutes."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.45, "construct": {"method_text_verbatim": "A \"standard\" matrix system refers to systems that are \"pre-loaded\" with the intent of keeping the pre-loaded perfume associated with the polymer until the moment, or moments of, perfume release. Such polymers may also suppress the neat product odor and provide a bloom and/or longevity benefit depending on the rate of perfume release. One challenge with such systems is to achieve the ideal balance between 1) in-product stability (keeping perfume inside carrier until you need it) and 2) timely release (during use or from dry situs). Achieving such stability is particularly important during in-product storage and product aging. This challenge is particularly apparent for aqueous-based, surfactant-containing products, such as heavy duty liquid laundry detergents. Many \"Standard\" matrix systems available effectively become \"Equilibrium\" systems when formulated into aqueous-based products. One may select an \"Equilibrium\" system or a Reservoir system, which has acceptable in-product diffusion", "panel_size": null, "property_name": "odor_intensity", "scale": "numeric_unknown", "substrate": null, "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "2005/0003980; 2004/0110648", "patent_id": "EP2931235B1", "provenance": {"citation": "EP2931235B1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP2931235B1/en"}, "pub_date": "2013-12-13", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:95", "units": "ordinal_ratio", "verbatim_quote": "A \"standard\" matrix system refers to systems that are \"pre-loaded\" with the intent of keeping the pre-loaded perfume associated with the polymer until the moment, or moments of, perfume release. Such polymers may also suppress the neat product odor and provide a bloom and/or longevity benefit depending on the rate of perfume release. One challenge with such systems is to achieve the ideal balance between 1) in-product stability (keeping perfume inside carrier until you need it) and 2) timely release (during use or from dry situs). Achieving such stability is particularly important during in-product storage and product aging. This challenge is particularly apparent for aqueous-based, surfactant-containing products, such as heavy duty liquid laundry detergents. Many \"Standard\" matrix systems available effectively become \"Equilibrium\" systems when formulated into aqueous-based products. One may select an \"Equilibrium\" system or a Reservoir system, which has acceptable in-product diffusion stability and available triggers for release (e.g., friction). \"Equilibrium\" systems are those in which the perfume and polymer may be added separately to the product, and the equilibrium interaction between perfume and polymer leads to a benefit at one or more consumer touch points (versus a free perfume control that has no polymer-assisted delivery technology). The polymer may also be pre-loaded with perfume; however, part or all of the perfume may diffuse during in-product storage reaching an equilibrium that includes having desired perfume raw materials (PRMs) associated with the polymer. The polymer then carries the perfume to the surface, and release is typically via perfume diffusion. The use of such equilibrium system polymers has the potential to decrease the neat product odor intensity of the neat product (usually more so in the case of pre-loaded standard system). Deposition of such polymers may serve to \"flatten\" the release profile and provide increased longevity. As indicated above, such longevity would be achieved by suppressing the initial intensity and may enable the formulator to use more high impact or low odor detection threshold (ODT) or low Kovats Index (KI) PRMs to achieve FMOT benefits without initial intensity that is too strong or distorted. It is important that perfume release occurs within the time frame of the application to impact the desired consumer touch point or touch points. Suitable micro-particles and micro-latexes as well as methods of making same may be found in U.S. Pre-Grant Publication No. 2005/0003980 A1 . Matrix systems also include hot melt adhesives and perfume plastics. In addition, hydrophobically modified polysaccharides may be formulated into the perfumed product to increase perfume deposition and/or modify perfume release. All such matrix systems, including for example polysaccharides and nanolatexes may be combined with other PDTs, including other PAD systems such as PAD reservoir systems in the form of a perfume microcapsule (PMC). Polymer Assisted Delivery (PAD) matrix systems may include those described in the following references: U.S. Pre-Grant Publication No. 2004/0110648 A1 and U.S. Patent No. 6,531,444 ."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.45, "construct": {"method_text_verbatim": "A \"standard\" matrix system refers to systems that are \"pre-loaded\" with the intent of keeping the pre-loaded perfume associated with the polymer until the moment, or moments of, perfume release. Such polymers may also suppress the neat product odor and provide a bloom and/or longevity benefit depending on the rate of perfume release. One challenge with such systems is to achieve the ideal balance between 1) in-product stability (keeping perfume inside carrier until you need it) and 2) timely release (during use or from dry situs). Achieving such stability is particularly important during in-product storage and product aging. This challenge is particularly apparent for aqueous-based, surfactant-containing products, such as heavy duty liquid laundry detergents. Many \"Standard\" matrix systems available effectively become \"Equilibrium\" systems when formulated into aqueous-based products. One may select an \"Equilibrium\" system or a Reservoir system, which has acceptable in-product diffusion", "panel_size": null, "property_name": "odor_intensity", "scale": "numeric_unknown", "substrate": null, "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "2005/0003980; 2004/0110648", "patent_id": "EP2931234B1", "provenance": {"citation": "EP2931234B1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP2931234B1/en"}, "pub_date": "2013-12-13", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:32", "units": "ordinal_ratio", "verbatim_quote": "A \"standard\" matrix system refers to systems that are \"pre-loaded\" with the intent of keeping the pre-loaded perfume associated with the polymer until the moment, or moments of, perfume release. Such polymers may also suppress the neat product odor and provide a bloom and/or longevity benefit depending on the rate of perfume release. One challenge with such systems is to achieve the ideal balance between 1) in-product stability (keeping perfume inside carrier until you need it) and 2) timely release (during use or from dry situs). Achieving such stability is particularly important during in-product storage and product aging. This challenge is particularly apparent for aqueous-based, surfactant-containing products, such as heavy duty liquid laundry detergents. Many \"Standard\" matrix systems available effectively become \"Equilibrium\" systems when formulated into aqueous-based products. One may select an \"Equilibrium\" system or a Reservoir system, which has acceptable in-product diffusion stability and available triggers for release (e.g., friction). \"Equilibrium\" systems are those in which the perfume and polymer may be added separately to the product, and the equilibrium interaction between perfume and polymer leads to a benefit at one or more consumer touch points (versus a free perfume control that has no polymer-assisted delivery technology). The polymer may also be pre-loaded with perfume; however, part or all of the perfume may diffuse during in-product storage reaching an equilibrium that includes having desired perfume raw materials (PRMs) associated with the polymer. The polymer then carries the perfume to the surface, and release is typically via perfume diffusion. The use of such equilibrium system polymers has the potential to decrease the neat product odor intensity of the neat product (usually more so in the case of pre-loaded standard system). Deposition of such polymers may serve to \"flatten\" the release profile and provide increased longevity. As indicated above, such longevity would be achieved by suppressing the initial intensity and may enable the formulator to use more high impact or low odor detection threshold (ODT) or low Kovats Index (KI) PRMs to achieve FMOT benefits without initial intensity that is too strong or distorted. It is important that perfume release occurs within the time frame of the application to impact the desired consumer touch point or touch points. Suitable micro-particles and micro-latexes as well as methods of making same may be found in U.S. Pre-Grant Publication No. 2005/0003980 A1 . Matrix systems also include hot melt adhesives and perfume plastics. In addition, hydrophobically modified polysaccharides may be formulated into the perfumed product to increase perfume deposition and/or modify perfume release. All such matrix systems, including for example polysaccharides and nanolatexes may be combined with other PDTs, including other PAD systems such as PAD reservoir systems in the form of a perfume microcapsule (PMC). Polymer Assisted Delivery (PAD) matrix systems may include those described in the following references: U.S. Pre-Grant Publication No. 2004/0110648 A1 and U.S. Patent No. 6,531,444 ."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": "Example 1", "confidence": 0.85, "construct": {"method_text_verbatim": "The results indicate that the Odor Detection Threshold increases significantly above baseline (test subjects are less sensitive) for the usage group using the formula containing the base perfume PD only, which was void of all sulfur and nitrogen PRM's after 4 weeks of usage, indicating habituation. Surprisingly, all components containing nitrogen chemistry showed improvement relative to the control. Table 8 Degree of Habituation (% change in group average ODT) Product Used Pink Daisy Perfume + Antihabituating material defined below for ODT Test Chemical Moiety of Antihabituating Material % Change in ODT at Week 4 Anti- habituation Index for four week test Formula X containing X.A - 3554 Highly Habituating, thus no index Formula X containing X.B 1-pyrazin-2-ylethanone (above threshold) Pyrazine comprising an acetyl moiety -84 4 Formula X containing X.C 3,7-dimethyloct-6-enenitrile (above threshold) Nitrile 221 Habituating, thus no index Formula X containing X.D 1H-indole (above threshol", "panel_size": null, "property_name": "duration", "scale": "percent", "substrate": null, "time_points": ["1H"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "1H", "patent_id": "EP2931234B1", "provenance": {"citation": "EP2931234B1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP2931234B1/en"}, "pub_date": "2013-12-13", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:294", "units": null, "verbatim_quote": "The results indicate that the Odor Detection Threshold increases significantly above baseline (test subjects are less sensitive) for the usage group using the formula containing the base perfume PD only, which was void of all sulfur and nitrogen PRM's after 4 weeks of usage, indicating habituation. Surprisingly, all components containing nitrogen chemistry showed improvement relative to the control. Table 8 Degree of Habituation (% change in group average ODT) Product Used Pink Daisy Perfume + Antihabituating material defined below for ODT Test Chemical Moiety of Antihabituating Material % Change in ODT at Week 4 Anti- habituation Index for four week test Formula X containing X.A - 3554 Highly Habituating, thus no index Formula X containing X.B 1-pyrazin-2-ylethanone (above threshold) Pyrazine comprising an acetyl moiety -84 4 Formula X containing X.C 3,7-dimethyloct-6-enenitrile (above threshold) Nitrile 221 Habituating, thus no index Formula X containing X.D 1H-indole (above threshold) Indole 208 Habituating, thus no index Formula X containing X.E Labienoxime (above threshold) Oxime -69 4 Formula X containing X.F 2-methoxy-3-(2-methylpropyl)pyrazine (below threshold) Pyrazine 110 Habituating, thus no index Formula X containing X.G 2-methoxy-3-(2-methylpropyl)pyrazine (above threshold) Pyrazine 339 Habituating, thus no index Formula XI Contains Comparative Perfume A Only 111 Habituating, thus no index Formula XII Contains Comparative Perfume C Only 405 Habituating, thus no index Formula X containing X,E is the only example falling within the scope of the invention. It is believed that the differences seen from Example 1, in which the base perfume had an anti-habituation index of 3 in the four week test, vs. Example 2, in which the base perfume had significant increase in ODT is beyond what is expected of individual variation among panelists and were related to the difference in perfume level (0.8% vs. 0.9%). Further, it is believed that the base perfume would be habituating, even at a lower perfume level if the test subjects used the product for a longer duration. The addition of nitrogen PRM's (non-sulfur-based) consistently showed greater resistance to habituation as compared to the control, regardless of perfume level tested."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Scientific Holdings LLC", "compound_ref_verbatim": null, "confidence": 0.55, "construct": {"method_text_verbatim": "At least the following methods are available for use in the present disclosure. Human panels have been trained to evaluate odors, such where the odors had the names, grassy green, green spicy, sweet, seasoned, sharp, soupy, mellow, metallic, fragrant fruity, cardboard-like, and complex (Kurobayashi et al (2006) Biosci. Biotechnol. Biochem. 70:958-965). The Kurobayashi et al, supra, study included detection of odor of terpenes, e.g., myrcene. Human panels have been trained to evaluate the level of odorants, including terpenes (linalool; L-carvone) on a scale of zero (extremely mild) to ten (extremely intense). Odorants were delivered to human subjects using an air stream. The subjects receiving the odorants, and providing subjective responses on odor intensity, also provided objective responses using electroolfactograms (EOG). The EOG test involved placing electrodes on the contralateral bridge of the nose, earlobe, and mastoids.", "panel_size": null, "property_name": "odor_intensity", "scale": "numeric_unknown", "substrate": null, "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "958-965", "patent_id": "US20240309289A1", "provenance": {"citation": "US20240309289A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20240309289A1/en"}, "pub_date": "2024-05-22", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:84", "units": null, "verbatim_quote": "At least the following methods are available for use in the present disclosure. Human panels have been trained to evaluate odors, such where the odors had the names, grassy green, green spicy, sweet, seasoned, sharp, soupy, mellow, metallic, fragrant fruity, cardboard-like, and complex (Kurobayashi et al (2006) Biosci. Biotechnol. Biochem. 70:958-965). The Kurobayashi et al, supra, study included detection of odor of terpenes, e.g., myrcene. Human panels have been trained to evaluate the level of odorants, including terpenes (linalool; L-carvone) on a scale of zero (extremely mild) to ten (extremely intense). Odorants were delivered to human subjects using an air stream. The subjects receiving the odorants, and providing subjective responses on odor intensity, also provided objective responses using electroolfactograms (EOG). The EOG test involved placing electrodes on the contralateral bridge of the nose, earlobe, and mastoids."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Scientific Holdings LLC", "compound_ref_verbatim": null, "confidence": 0.6, "construct": {"method_text_verbatim": "The present disclosure provides terpene compositions that contain individual terpenes with a high volatility and low substantivity. Chemicals with a high volatility and low substantivity are used to give an initial burst of characters, such as light, fresh, fruity, citrus, green or floral, which are detected soon after application. Such materials are referred to, by the artisan skilled in the field of fragrances as \u201ctop notes\u201d. Less volatile, and more substantive, chemicals, at least in perfumes, are used to give characters such as musk, sweet, balsamic, spicy, woody or heavy floral to the fragrance oil which, although may also be detected soon after application, also last for longer. The skilled artisan refers to these materials as \u201cmiddle notes\u201d or \u201cbase notes\u201d. The skilled artisan can blend perfume raw materials so that the resultant fragrance oils have the desired overall fragrance character profile (see U.S. Pat. No. 7,208,464 of Heltovics, which is incorporated herein by referenc", "panel_size": null, "property_name": "substantivity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["2 hours", "6 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "2 hours; 6 hours", "patent_id": "US20240309289A1", "provenance": {"citation": "US20240309289A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20240309289A1/en"}, "pub_date": "2024-05-22", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:94", "units": "hours", "verbatim_quote": "The present disclosure provides terpene compositions that contain individual terpenes with a high volatility and low substantivity. Chemicals with a high volatility and low substantivity are used to give an initial burst of characters, such as light, fresh, fruity, citrus, green or floral, which are detected soon after application. Such materials are referred to, by the artisan skilled in the field of fragrances as \u201ctop notes\u201d. Less volatile, and more substantive, chemicals, at least in perfumes, are used to give characters such as musk, sweet, balsamic, spicy, woody or heavy floral to the fragrance oil which, although may also be detected soon after application, also last for longer. The skilled artisan refers to these materials as \u201cmiddle notes\u201d or \u201cbase notes\u201d. The skilled artisan can blend perfume raw materials so that the resultant fragrance oils have the desired overall fragrance character profile (see U.S. Pat. No. 7,208,464 of Heltovics, which is incorporated herein by reference in its entirety). \u201cTop note\u201d fragrances are \u201cfragrances having a high vapor pressure, and when applied to a paper sachet, vaporization takes place within 2 hours, and no scent remains. \u201cMiddle note\u201d fragrances are \u201cfragrances having a medium vapor pressure, and when applied to a paper sachet, the scent remains from about 2 to about 6 hours. \u201cBase note\u201d fragrances are fragrances having a low vapor pressure and high retentivity, and when applied to a paper sachet, the scent remains for more than about 6 hours. The terms \u201ctop note\u201d, \u201cmiddle note\u201d, and \u201cbase note\u201d are recognized by those skilled in the art of fragrance-containing compositions. See, U.S. Pat. No. 6,013,618 of Morelli, which is incorporated herein by reference in its entirety."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Werc Shop LLC", "compound_ref_verbatim": null, "confidence": 0.55, "construct": {"method_text_verbatim": "At least the following methods are available for use in the present disclosure. Human panels have been trained to evaluate odors, such where the odors had the names, grassy green, green spicy, sweet, seasoned, sharp, soupy, mellow, metallic, fragrant fruity, cardboard-like, and complex (Kurobayashi et al (2006) Biosci. Biotechnol. Biochem. 70:958-965). The Kurobayashi et al, supra, study included detection of odor of terpenes, e.g., myrcene. Human panels have been trained to evaluate the level of odorants, including terpenes (linalool; L-carvone) on a scale of zero (extremely mild) to ten (extremely intense). Odorants were delivered to human subjects using an air stream. The subjects receiving the odorants, and providing subjective responses on odor intensity, also provided objective responses using electroolfactograms (EOG). The EOG test involved placing electrodes on the contralateral bridge of the nose, earlobe, and mastoids.", "panel_size": null, "property_name": "odor_intensity", "scale": "numeric_unknown", "substrate": null, "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "958-965", "patent_id": "US20210071104A1", "provenance": {"citation": "US20210071104A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20210071104A1/en"}, "pub_date": "2020-08-25", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:84", "units": null, "verbatim_quote": "At least the following methods are available for use in the present disclosure. Human panels have been trained to evaluate odors, such where the odors had the names, grassy green, green spicy, sweet, seasoned, sharp, soupy, mellow, metallic, fragrant fruity, cardboard-like, and complex (Kurobayashi et al (2006) Biosci. Biotechnol. Biochem. 70:958-965). The Kurobayashi et al, supra, study included detection of odor of terpenes, e.g., myrcene. Human panels have been trained to evaluate the level of odorants, including terpenes (linalool; L-carvone) on a scale of zero (extremely mild) to ten (extremely intense). Odorants were delivered to human subjects using an air stream. The subjects receiving the odorants, and providing subjective responses on odor intensity, also provided objective responses using electroolfactograms (EOG). The EOG test involved placing electrodes on the contralateral bridge of the nose, earlobe, and mastoids."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Werc Shop LLC", "compound_ref_verbatim": null, "confidence": 0.6, "construct": {"method_text_verbatim": "The present disclosure provides terpene compositions that contain individual terpenes with a high volatility and low substantivity. Chemicals with a high volatility and low substantivity are used to give an initial burst of characters, such as light, fresh, fruity, citrus, green or floral, which are detected soon after application. Such materials are referred to, by the artisan skilled in the field of fragrances as \u201ctop notes\u201d. Less volatile, and more substantive, chemicals, at least in perfumes, are used to give characters such as musk, sweet, balsamic, spicy, woody or heavy floral to the fragrance oil which, although may also be detected soon after application, also last for longer. The skilled artisan refers to these materials as \u201cmiddle notes\u201d or \u201cbase notes\u201d. The skilled artisan can blend perfume raw materials so that the resultant fragrance oils have the desired overall fragrance character profile (see U.S. Pat. No. 7,208,464 of Heltovics, which is incorporated herein by referenc", "panel_size": null, "property_name": "substantivity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["2 hours", "6 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "2 hours; 6 hours", "patent_id": "US20210071104A1", "provenance": {"citation": "US20210071104A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20210071104A1/en"}, "pub_date": "2020-08-25", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:96", "units": "hours", "verbatim_quote": "The present disclosure provides terpene compositions that contain individual terpenes with a high volatility and low substantivity. Chemicals with a high volatility and low substantivity are used to give an initial burst of characters, such as light, fresh, fruity, citrus, green or floral, which are detected soon after application. Such materials are referred to, by the artisan skilled in the field of fragrances as \u201ctop notes\u201d. Less volatile, and more substantive, chemicals, at least in perfumes, are used to give characters such as musk, sweet, balsamic, spicy, woody or heavy floral to the fragrance oil which, although may also be detected soon after application, also last for longer. The skilled artisan refers to these materials as \u201cmiddle notes\u201d or \u201cbase notes\u201d. The skilled artisan can blend perfume raw materials so that the resultant fragrance oils have the desired overall fragrance character profile (see U.S. Pat. No. 7,208,464 of Heltovics, which is incorporated herein by reference in its entirety). \u201cTop note\u201d fragrances are \u201cfragrances having a high vapor pressure, and when applied to a paper sachet, vaporization takes place within 2 hours, and no scent remains. \u201cMiddle note\u201d fragrances are \u201cfragrances having a medium vapor pressure, and when applied to a paper sachet, the scent remains from about 2 to about 6 hours. \u201cBase note\u201d fragrances are fragrances having a low vapor pressure and high retentivity, and when applied to a paper sachet, the scent remains for more than about 6 hours. The terms \u201ctop note\u201d, \u201cmiddle note\u201d, and \u201cbase note\u201d are recognized by those skilled in the art of fragrance-containing compositions. See, U.S. Pat. No. 6,013,618 of Morelli, which is incorporated herein by reference in its entirety."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Werc Shop LLC", "compound_ref_verbatim": null, "confidence": 0.55, "construct": {"method_text_verbatim": "At least the following methods are available for use in the present disclosure. Human panels have been trained to evaluate odors, such where the odors had the names, grassy green, green spicy, sweet, seasoned, sharp, soupy, mellow, metallic, fragrant fruity, cardboard-like, and complex (Kurobayashi et al (2006) Biosci. Biotechnol. Biochem. 70:958-965). The Kurobayashi et al, supra, study included detection of odor of terpenes, e.g., myrcene. Human panels have been trained to evaluate the level of odorants, including terpenes (linalool; L-carvone) on a scale of zero (extremely mild) to ten (extremely intense). Odorants were delivered to human subjects using an air stream. The subjects receiving the odorants, and providing subjective responses on odor intensity, also provided objective responses using electroolfactograms (EOG). The EOG test involved placing electrodes on the contralateral bridge of the nose, earlobe, and mastoids.", "panel_size": null, "property_name": "odor_intensity", "scale": "numeric_unknown", "substrate": null, "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "958-965", "patent_id": "US20210017468A1", "provenance": {"citation": "US20210017468A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20210017468A1/en"}, "pub_date": "2020-08-25", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:84", "units": null, "verbatim_quote": "At least the following methods are available for use in the present disclosure. Human panels have been trained to evaluate odors, such where the odors had the names, grassy green, green spicy, sweet, seasoned, sharp, soupy, mellow, metallic, fragrant fruity, cardboard-like, and complex (Kurobayashi et al (2006) Biosci. Biotechnol. Biochem. 70:958-965). The Kurobayashi et al, supra, study included detection of odor of terpenes, e.g., myrcene. Human panels have been trained to evaluate the level of odorants, including terpenes (linalool; L-carvone) on a scale of zero (extremely mild) to ten (extremely intense). Odorants were delivered to human subjects using an air stream. The subjects receiving the odorants, and providing subjective responses on odor intensity, also provided objective responses using electroolfactograms (EOG). The EOG test involved placing electrodes on the contralateral bridge of the nose, earlobe, and mastoids."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Werc Shop LLC", "compound_ref_verbatim": null, "confidence": 0.6, "construct": {"method_text_verbatim": "The present disclosure provides terpene compositions that contain individual terpenes with a high volatility and low substantivity. Chemicals with a high volatility and low substantivity are used to give an initial burst of characters, such as light, fresh, fruity, citrus, green or floral, which are detected soon after application. Such materials are referred to, by the artisan skilled in the field of fragrances as \u201ctop notes\u201d. Less volatile, and more substantive, chemicals, at least in perfumes, are used to give characters such as musk, sweet, balsamic, spicy, woody or heavy floral to the fragrance oil which, although may also be detected soon after application, also last for longer. The skilled artisan refers to these materials as \u201cmiddle notes\u201d or \u201cbase notes\u201d. The skilled artisan can blend perfume raw materials so that the resultant fragrance oils have the desired overall fragrance character profile (see U.S. Pat. No. 7,208,464 of Heltovics, which is incorporated herein by referenc", "panel_size": null, "property_name": "substantivity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["2 hours", "6 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "2 hours; 6 hours", "patent_id": "US20210017468A1", "provenance": {"citation": "US20210017468A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20210017468A1/en"}, "pub_date": "2020-08-25", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:96", "units": "hours", "verbatim_quote": "The present disclosure provides terpene compositions that contain individual terpenes with a high volatility and low substantivity. Chemicals with a high volatility and low substantivity are used to give an initial burst of characters, such as light, fresh, fruity, citrus, green or floral, which are detected soon after application. Such materials are referred to, by the artisan skilled in the field of fragrances as \u201ctop notes\u201d. Less volatile, and more substantive, chemicals, at least in perfumes, are used to give characters such as musk, sweet, balsamic, spicy, woody or heavy floral to the fragrance oil which, although may also be detected soon after application, also last for longer. The skilled artisan refers to these materials as \u201cmiddle notes\u201d or \u201cbase notes\u201d. The skilled artisan can blend perfume raw materials so that the resultant fragrance oils have the desired overall fragrance character profile (see U.S. Pat. No. 7,208,464 of Heltovics, which is incorporated herein by reference in its entirety). \u201cTop note\u201d fragrances are \u201cfragrances having a high vapor pressure, and when applied to a paper sachet, vaporization takes place within 2 hours, and no scent remains. \u201cMiddle note\u201d fragrances are \u201cfragrances having a medium vapor pressure, and when applied to a paper sachet, the scent remains from about 2 to about 6 hours. \u201cBase note\u201d fragrances are fragrances having a low vapor pressure and high retentivity, and when applied to a paper sachet, the scent remains for more than about 6 hours. The terms \u201ctop note\u201d, \u201cmiddle note\u201d, and \u201cbase note\u201d are recognized by those skilled in the art of fragrance-containing compositions. See, U.S. Pat. No. 6,013,618 of Morelli, which is incorporated herein by reference in its entirety."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Scientific Holdings LLC", "compound_ref_verbatim": null, "confidence": 0.55, "construct": {"method_text_verbatim": "At least the following methods are available for use in the present disclosure. Human panels have been trained to evaluate odors, such where the odors had the names, grassy green, green spicy, sweet, seasoned, sharp, soupy, mellow, metallic, fragrant fruity, cardboard-like, and complex (Kurobayashi et al (2006) Biosci. Biotechnol. Biochem. 70:958-965). The Kurobayashi et al, supra, study included detection of odor of terpenes, e.g., myrcene. Human panels have been trained to evaluate the level of odorants, including terpenes (linalool; L-carvone) on a scale of zero (extremely mild) to ten (extremely intense). Odorants were delivered to human subjects using an air stream. The subjects receiving the odorants, and providing subjective responses on odor intensity, also provided objective responses using electroolfactograms (EOG). The EOG test involved placing electrodes on the contralateral bridge of the nose, earlobe, and mastoids.", "panel_size": null, "property_name": "odor_intensity", "scale": "numeric_unknown", "substrate": null, "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "958-965", "patent_id": "US20240309288A1", "provenance": {"citation": "US20240309288A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20240309288A1/en"}, "pub_date": "2024-05-22", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:84", "units": null, "verbatim_quote": "At least the following methods are available for use in the present disclosure. Human panels have been trained to evaluate odors, such where the odors had the names, grassy green, green spicy, sweet, seasoned, sharp, soupy, mellow, metallic, fragrant fruity, cardboard-like, and complex (Kurobayashi et al (2006) Biosci. Biotechnol. Biochem. 70:958-965). The Kurobayashi et al, supra, study included detection of odor of terpenes, e.g., myrcene. Human panels have been trained to evaluate the level of odorants, including terpenes (linalool; L-carvone) on a scale of zero (extremely mild) to ten (extremely intense). Odorants were delivered to human subjects using an air stream. The subjects receiving the odorants, and providing subjective responses on odor intensity, also provided objective responses using electroolfactograms (EOG). The EOG test involved placing electrodes on the contralateral bridge of the nose, earlobe, and mastoids."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Scientific Holdings LLC", "compound_ref_verbatim": null, "confidence": 0.6, "construct": {"method_text_verbatim": "The present disclosure provides terpene compositions that contain individual terpenes with a high volatility and low substantivity. Chemicals with a high volatility and low substantivity are used to give an initial burst of characters, such as light, fresh, fruity, citrus, green or floral, which are detected soon after application. Such materials are referred to, by the artisan skilled in the field of fragrances as \u201ctop notes\u201d. Less volatile, and more substantive, chemicals, at least in perfumes, are used to give characters such as musk, sweet, balsamic, spicy, woody or heavy floral to the fragrance oil which, although may also be detected soon after application, also last for longer. The skilled artisan refers to these materials as \u201cmiddle notes\u201d or \u201cbase notes\u201d. The skilled artisan can blend perfume raw materials so that the resultant fragrance oils have the desired overall fragrance character profile (see U.S. Pat. No. 7,208,464 of Heltovics, which is incorporated herein by referenc", "panel_size": null, "property_name": "substantivity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["2 hours", "6 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "2 hours; 6 hours", "patent_id": "US20240309288A1", "provenance": {"citation": "US20240309288A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20240309288A1/en"}, "pub_date": "2024-05-22", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:94", "units": "hours", "verbatim_quote": "The present disclosure provides terpene compositions that contain individual terpenes with a high volatility and low substantivity. Chemicals with a high volatility and low substantivity are used to give an initial burst of characters, such as light, fresh, fruity, citrus, green or floral, which are detected soon after application. Such materials are referred to, by the artisan skilled in the field of fragrances as \u201ctop notes\u201d. Less volatile, and more substantive, chemicals, at least in perfumes, are used to give characters such as musk, sweet, balsamic, spicy, woody or heavy floral to the fragrance oil which, although may also be detected soon after application, also last for longer. The skilled artisan refers to these materials as \u201cmiddle notes\u201d or \u201cbase notes\u201d. The skilled artisan can blend perfume raw materials so that the resultant fragrance oils have the desired overall fragrance character profile (see U.S. Pat. No. 7,208,464 of Heltovics, which is incorporated herein by reference in its entirety). \u201cTop note\u201d fragrances are \u201cfragrances having a high vapor pressure, and when applied to a paper sachet, vaporization takes place within 2 hours, and no scent remains. \u201cMiddle note\u201d fragrances are \u201cfragrances having a medium vapor pressure, and when applied to a paper sachet, the scent remains from about 2 to about 6 hours. \u201cBase note\u201d fragrances are fragrances having a low vapor pressure and high retentivity, and when applied to a paper sachet, the scent remains for more than about 6 hours. The terms \u201ctop note\u201d, \u201cmiddle note\u201d, and \u201cbase note\u201d are recognized by those skilled in the art of fragrance-containing compositions. See, U.S. Pat. No. 6,013,618 of Morelli, which is incorporated herein by reference in its entirety."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Scientific Holdings LLC", "compound_ref_verbatim": null, "confidence": 0.55, "construct": {"method_text_verbatim": "At least the following methods are available for use in the present disclosure. Human panels have been trained to evaluate odors, such where the odors had the names, grassy green, green spicy, sweet, seasoned, sharp, soupy, mellow, metallic, fragrant fruity, cardboard-like, and complex (Kurobayashi et al (2006) Biosci. Biotechnol. Biochem. 70:958-965). The Kurobayashi et al, supra, study included detection of odor of terpenes, e.g., myrcene. Human panels have been trained to evaluate the level of odorants, including terpenes (linalool; L-carvone) on a scale of zero (extremely mild) to ten (extremely intense). Odorants were delivered to human subjects using an air stream. The subjects receiving the odorants, and providing subjective responses on odor intensity, also provided objective responses using electroolfactograms (EOG). The EOG test involved placing electrodes on the contralateral bridge of the nose, earlobe, and mastoids.", "panel_size": null, "property_name": "odor_intensity", "scale": "numeric_unknown", "substrate": null, "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "958-965", "patent_id": "US20240110124A1", "provenance": {"citation": "US20240110124A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20240110124A1/en"}, "pub_date": "2023-12-05", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:84", "units": null, "verbatim_quote": "At least the following methods are available for use in the present disclosure. Human panels have been trained to evaluate odors, such where the odors had the names, grassy green, green spicy, sweet, seasoned, sharp, soupy, mellow, metallic, fragrant fruity, cardboard-like, and complex (Kurobayashi et al (2006) Biosci. Biotechnol. Biochem. 70:958-965). The Kurobayashi et al, supra, study included detection of odor of terpenes, e.g., myrcene. Human panels have been trained to evaluate the level of odorants, including terpenes (linalool; L-carvone) on a scale of zero (extremely mild) to ten (extremely intense). Odorants were delivered to human subjects using an air stream. The subjects receiving the odorants, and providing subjective responses on odor intensity, also provided objective responses using electroolfactograms (EOG). The EOG test involved placing electrodes on the contralateral bridge of the nose, earlobe, and mastoids."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Scientific Holdings LLC", "compound_ref_verbatim": null, "confidence": 0.6, "construct": {"method_text_verbatim": "The present disclosure provides terpene compositions that contain individual terpenes with a high volatility and low substantivity. Chemicals with a high volatility and low substantivity are used to give an initial burst of characters, such as light, fresh, fruity, citrus, green or floral, which are detected soon after application. Such materials are referred to, by the artisan skilled in the field of fragrances as \u201ctop notes\u201d. Less volatile, and more substantive, chemicals, at least in perfumes, are used to give characters such as musk, sweet, balsamic, spicy, woody or heavy floral to the fragrance oil which, although may also be detected soon after application, also last for longer. The skilled artisan refers to these materials as \u201cmiddle notes\u201d or \u201cbase notes\u201d. The skilled artisan can blend perfume raw materials so that the resultant fragrance oils have the desired overall fragrance character profile (see U.S. Pat. No. 7,208,464 of Heltovics, which is incorporated herein by referenc", "panel_size": null, "property_name": "substantivity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["2 hours", "6 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "2 hours; 6 hours", "patent_id": "US20240110124A1", "provenance": {"citation": "US20240110124A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20240110124A1/en"}, "pub_date": "2023-12-05", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:96", "units": "hours", "verbatim_quote": "The present disclosure provides terpene compositions that contain individual terpenes with a high volatility and low substantivity. Chemicals with a high volatility and low substantivity are used to give an initial burst of characters, such as light, fresh, fruity, citrus, green or floral, which are detected soon after application. Such materials are referred to, by the artisan skilled in the field of fragrances as \u201ctop notes\u201d. Less volatile, and more substantive, chemicals, at least in perfumes, are used to give characters such as musk, sweet, balsamic, spicy, woody or heavy floral to the fragrance oil which, although may also be detected soon after application, also last for longer. The skilled artisan refers to these materials as \u201cmiddle notes\u201d or \u201cbase notes\u201d. The skilled artisan can blend perfume raw materials so that the resultant fragrance oils have the desired overall fragrance character profile (see U.S. Pat. No. 7,208,464 of Heltovics, which is incorporated herein by reference in its entirety). \u201cTop note\u201d fragrances are \u201cfragrances having a high vapor pressure, and when applied to a paper sachet, vaporization takes place within 2 hours, and no scent remains. \u201cMiddle note\u201d fragrances are \u201cfragrances having a medium vapor pressure, and when applied to a paper sachet, the scent remains from about 2 to about 6 hours. \u201cBase note\u201d fragrances are fragrances having a low vapor pressure and high retentivity, and when applied to a paper sachet, the scent remains for more than about 6 hours. The terms \u201ctop note\u201d, \u201cmiddle note\u201d, and \u201cbase note\u201d are recognized by those skilled in the art of fragrance-containing compositions. See, U.S. Pat. No. 6,013,618 of Morelli, which is incorporated herein by reference in its entirety."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Scientific Holdings LLC", "compound_ref_verbatim": null, "confidence": 0.55, "construct": {"method_text_verbatim": "At least the following methods are available for use in the present disclosure. Human panels have been trained to evaluate odors, such where the odors had the names, grassy green, green spicy, sweet, seasoned, sharp, soupy, mellow, metallic, fragrant fruity, cardboard-like, and complex (Kurobayashi et al (2006) Biosci. Biotechnol. Biochem. 70:958-965). The Kurobayashi et al, supra, study included detection of odor of terpenes, e.g., myrcene. Human panels have been trained to evaluate the level of odorants, including terpenes (linalool; L-carvone) on a scale of zero (extremely mild) to ten (extremely intense). Odorants were delivered to human subjects using an air stream. The subjects receiving the odorants, and providing subjective responses on odor intensity, also provided objective responses using electroolfactograms (EOG). The EOG test involved placing electrodes on the contralateral bridge of the nose, earlobe, and mastoids.", "panel_size": null, "property_name": "odor_intensity", "scale": "numeric_unknown", "substrate": null, "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "958-965", "patent_id": "US20240318097A1", "provenance": {"citation": "US20240318097A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20240318097A1/en"}, "pub_date": "2024-05-22", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:84", "units": null, "verbatim_quote": "At least the following methods are available for use in the present disclosure. Human panels have been trained to evaluate odors, such where the odors had the names, grassy green, green spicy, sweet, seasoned, sharp, soupy, mellow, metallic, fragrant fruity, cardboard-like, and complex (Kurobayashi et al (2006) Biosci. Biotechnol. Biochem. 70:958-965). The Kurobayashi et al, supra, study included detection of odor of terpenes, e.g., myrcene. Human panels have been trained to evaluate the level of odorants, including terpenes (linalool; L-carvone) on a scale of zero (extremely mild) to ten (extremely intense). Odorants were delivered to human subjects using an air stream. The subjects receiving the odorants, and providing subjective responses on odor intensity, also provided objective responses using electroolfactograms (EOG). The EOG test involved placing electrodes on the contralateral bridge of the nose, earlobe, and mastoids."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Scientific Holdings LLC", "compound_ref_verbatim": null, "confidence": 0.6, "construct": {"method_text_verbatim": "The present disclosure provides terpene compositions that contain individual terpenes with a high volatility and low substantivity. Chemicals with a high volatility and low substantivity are used to give an initial burst of characters, such as light, fresh, fruity, citrus, green or floral, which are detected soon after application. Such materials are referred to, by the artisan skilled in the field of fragrances as \u201ctop notes\u201d. Less volatile, and more substantive, chemicals, at least in perfumes, are used to give characters such as musk, sweet, balsamic, spicy, woody or heavy floral to the fragrance oil which, although may also be detected soon after application, also last for longer. The skilled artisan refers to these materials as \u201cmiddle notes\u201d or \u201cbase notes\u201d. The skilled artisan can blend perfume raw materials so that the resultant fragrance oils have the desired overall fragrance character profile (see U.S. Pat. No. 7,208,464 of Heltovics, which is incorporated herein by referenc", "panel_size": null, "property_name": "substantivity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["2 hours", "6 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "2 hours; 6 hours", "patent_id": "US20240318097A1", "provenance": {"citation": "US20240318097A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20240318097A1/en"}, "pub_date": "2024-05-22", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:94", "units": "hours", "verbatim_quote": "The present disclosure provides terpene compositions that contain individual terpenes with a high volatility and low substantivity. Chemicals with a high volatility and low substantivity are used to give an initial burst of characters, such as light, fresh, fruity, citrus, green or floral, which are detected soon after application. Such materials are referred to, by the artisan skilled in the field of fragrances as \u201ctop notes\u201d. Less volatile, and more substantive, chemicals, at least in perfumes, are used to give characters such as musk, sweet, balsamic, spicy, woody or heavy floral to the fragrance oil which, although may also be detected soon after application, also last for longer. The skilled artisan refers to these materials as \u201cmiddle notes\u201d or \u201cbase notes\u201d. The skilled artisan can blend perfume raw materials so that the resultant fragrance oils have the desired overall fragrance character profile (see U.S. Pat. No. 7,208,464 of Heltovics, which is incorporated herein by reference in its entirety). \u201cTop note\u201d fragrances are \u201cfragrances having a high vapor pressure, and when applied to a paper sachet, vaporization takes place within 2 hours, and no scent remains. \u201cMiddle note\u201d fragrances are \u201cfragrances having a medium vapor pressure, and when applied to a paper sachet, the scent remains from about 2 to about 6 hours. \u201cBase note\u201d fragrances are fragrances having a low vapor pressure and high retentivity, and when applied to a paper sachet, the scent remains for more than about 6 hours. The terms \u201ctop note\u201d, \u201cmiddle note\u201d, and \u201cbase note\u201d are recognized by those skilled in the art of fragrance-containing compositions. See, U.S. Pat. No. 6,013,618 of Morelli, which is incorporated herein by reference in its entirety."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Scientific Holdings LLC", "compound_ref_verbatim": null, "confidence": 0.55, "construct": {"method_text_verbatim": "At least the following methods are available for use in the present disclosure. Human panels have been trained to evaluate odors, such where the odors had the names, grassy green, green spicy, sweet, seasoned, sharp, soupy, mellow, metallic, fragrant fruity, cardboard-like, and complex (Kurobayashi et al (2006) Biosci. Biotechnol. Biochem. 70:958-965). The Kurobayashi et al, supra, study included detection of odor of terpenes, e.g., myrcene. Human panels have been trained to evaluate the level of odorants, including terpenes (linalool; L-carvone) on a scale of zero (extremely mild) to ten (extremely intense). Odorants were delivered to human subjects using an air stream. The subjects receiving the odorants, and providing subjective responses on odor intensity, also provided objective responses using electroolfactograms (EOG). The EOG test involved placing electrodes on the contralateral bridge of the nose, earlobe, and mastoids.", "panel_size": null, "property_name": "odor_intensity", "scale": "numeric_unknown", "substrate": null, "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "958-965", "patent_id": "US20250011681A1", "provenance": {"citation": "US20250011681A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20250011681A1/en"}, "pub_date": "2024-09-20", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:85", "units": null, "verbatim_quote": "At least the following methods are available for use in the present disclosure. Human panels have been trained to evaluate odors, such where the odors had the names, grassy green, green spicy, sweet, seasoned, sharp, soupy, mellow, metallic, fragrant fruity, cardboard-like, and complex (Kurobayashi et al (2006) Biosci. Biotechnol. Biochem. 70:958-965). The Kurobayashi et al, supra, study included detection of odor of terpenes, e.g., myrcene. Human panels have been trained to evaluate the level of odorants, including terpenes (linalool; L-carvone) on a scale of zero (extremely mild) to ten (extremely intense). Odorants were delivered to human subjects using an air stream. The subjects receiving the odorants, and providing subjective responses on odor intensity, also provided objective responses using electroolfactograms (EOG). The EOG test involved placing electrodes on the contralateral bridge of the nose, earlobe, and mastoids."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Scientific Holdings LLC", "compound_ref_verbatim": null, "confidence": 0.6, "construct": {"method_text_verbatim": "The present disclosure provides terpene compositions that contain individual terpenes with a high volatility and low substantivity. Chemicals with a high volatility and low substantivity are used to give an initial burst of characters, such as light, fresh, fruity, citrus, green or floral, which are detected soon after application. Such materials are referred to, by the artisan skilled in the field of fragrances as \u201ctop notes\u201d. Less volatile, and more substantive, chemicals, at least in perfumes, are used to give characters such as musk, sweet, balsamic, spicy, woody or heavy floral to the fragrance oil which, although may also be detected soon after application, also last for longer. The skilled artisan refers to these materials as \u201cmiddle notes\u201d or \u201cbase notes\u201d. The skilled artisan can blend perfume raw materials so that the resultant fragrance oils have the desired overall fragrance character profile (see U.S. Pat. No. 7,208,464 of Heltovics, which is incorporated herein by referenc", "panel_size": null, "property_name": "substantivity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["2 hours", "6 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "2 hours; 6 hours", "patent_id": "US20250011681A1", "provenance": {"citation": "US20250011681A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20250011681A1/en"}, "pub_date": "2024-09-20", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:95", "units": "hours", "verbatim_quote": "The present disclosure provides terpene compositions that contain individual terpenes with a high volatility and low substantivity. Chemicals with a high volatility and low substantivity are used to give an initial burst of characters, such as light, fresh, fruity, citrus, green or floral, which are detected soon after application. Such materials are referred to, by the artisan skilled in the field of fragrances as \u201ctop notes\u201d. Less volatile, and more substantive, chemicals, at least in perfumes, are used to give characters such as musk, sweet, balsamic, spicy, woody or heavy floral to the fragrance oil which, although may also be detected soon after application, also last for longer. The skilled artisan refers to these materials as \u201cmiddle notes\u201d or \u201cbase notes\u201d. The skilled artisan can blend perfume raw materials so that the resultant fragrance oils have the desired overall fragrance character profile (see U.S. Pat. No. 7,208,464 of Heltovics, which is incorporated herein by reference in its entirety). \u201cTop note\u201d fragrances are \u201cfragrances having a high vapor pressure, and when applied to a paper sachet, vaporization takes place within 2 hours, and no scent remains. \u201cMiddle note\u201d fragrances are \u201cfragrances having a medium vapor pressure, and when applied to a paper sachet, the scent remains from about 2 to about 6 hours. \u201cBase note\u201d fragrances are fragrances having a low vapor pressure and high retentivity, and when applied to a paper sachet, the scent remains for more than about 6 hours. The terms \u201ctop note\u201d, \u201cmiddle note\u201d, and \u201cbase note\u201d are recognized by those skilled in the art of fragrance-containing compositions. See, U.S. Pat. No. 6,013,618 of Morelli, which is incorporated herein by reference in its entirety."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Scientific Holdings LLC", "compound_ref_verbatim": null, "confidence": 0.55, "construct": {"method_text_verbatim": "At least the following methods are available for use in the present disclosure. Human panels have been trained to evaluate odors, such where the odors had the names, grassy green, green spicy, sweet, seasoned, sharp, soupy, mellow, metallic, fragrant fruity, cardboard-like, and complex (Kurobayashi et al (2006) Biosci. Biotechnol. Biochem. 70:958-965). The Kurobayashi et al, supra, study included detection of odor of terpenes, e.g., myrcene. Human panels have been trained to evaluate the level of odorants, including terpenes (linalool; L-carvone) on a scale of zero (extremely mild) to ten (extremely intense). Odorants were delivered to human subjects using an air stream. The subjects receiving the odorants, and providing subjective responses on odor intensity, also provided objective responses using electroolfactograms (EOG). The EOG test involved placing electrodes on the contralateral bridge of the nose, earlobe, and mastoids.", "panel_size": null, "property_name": "odor_intensity", "scale": "numeric_unknown", "substrate": null, "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "958-965", "patent_id": "US20240327750A1", "provenance": {"citation": "US20240327750A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20240327750A1/en"}, "pub_date": "2024-05-22", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:84", "units": null, "verbatim_quote": "At least the following methods are available for use in the present disclosure. Human panels have been trained to evaluate odors, such where the odors had the names, grassy green, green spicy, sweet, seasoned, sharp, soupy, mellow, metallic, fragrant fruity, cardboard-like, and complex (Kurobayashi et al (2006) Biosci. Biotechnol. Biochem. 70:958-965). The Kurobayashi et al, supra, study included detection of odor of terpenes, e.g., myrcene. Human panels have been trained to evaluate the level of odorants, including terpenes (linalool; L-carvone) on a scale of zero (extremely mild) to ten (extremely intense). Odorants were delivered to human subjects using an air stream. The subjects receiving the odorants, and providing subjective responses on odor intensity, also provided objective responses using electroolfactograms (EOG). The EOG test involved placing electrodes on the contralateral bridge of the nose, earlobe, and mastoids."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Scientific Holdings LLC", "compound_ref_verbatim": null, "confidence": 0.6, "construct": {"method_text_verbatim": "The present disclosure provides terpene compositions that contain individual terpenes with a high volatility and low substantivity. Chemicals with a high volatility and low substantivity are used to give an initial burst of characters, such as light, fresh, fruity, citrus, green or floral, which are detected soon after application. Such materials are referred to, by the artisan skilled in the field of fragrances as \u201ctop notes\u201d. Less volatile, and more substantive, chemicals, at least in perfumes, are used to give characters such as musk, sweet, balsamic, spicy, woody or heavy floral to the fragrance oil which, although may also be detected soon after application, also last for longer. The skilled artisan refers to these materials as \u201cmiddle notes\u201d or \u201cbase notes\u201d. The skilled artisan can blend perfume raw materials so that the resultant fragrance oils have the desired overall fragrance character profile (see U.S. Pat. No. 7,208,464 of Heltovics, which is incorporated herein by referenc", "panel_size": null, "property_name": "substantivity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["2 hours", "6 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "2 hours; 6 hours", "patent_id": "US20240327750A1", "provenance": {"citation": "US20240327750A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20240327750A1/en"}, "pub_date": "2024-05-22", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:94", "units": "hours", "verbatim_quote": "The present disclosure provides terpene compositions that contain individual terpenes with a high volatility and low substantivity. Chemicals with a high volatility and low substantivity are used to give an initial burst of characters, such as light, fresh, fruity, citrus, green or floral, which are detected soon after application. Such materials are referred to, by the artisan skilled in the field of fragrances as \u201ctop notes\u201d. Less volatile, and more substantive, chemicals, at least in perfumes, are used to give characters such as musk, sweet, balsamic, spicy, woody or heavy floral to the fragrance oil which, although may also be detected soon after application, also last for longer. The skilled artisan refers to these materials as \u201cmiddle notes\u201d or \u201cbase notes\u201d. The skilled artisan can blend perfume raw materials so that the resultant fragrance oils have the desired overall fragrance character profile (see U.S. Pat. No. 7,208,464 of Heltovics, which is incorporated herein by reference in its entirety). \u201cTop note\u201d fragrances are \u201cfragrances having a high vapor pressure, and when applied to a paper sachet, vaporization takes place within 2 hours, and no scent remains. \u201cMiddle note\u201d fragrances are \u201cfragrances having a medium vapor pressure, and when applied to a paper sachet, the scent remains from about 2 to about 6 hours. \u201cBase note\u201d fragrances are fragrances having a low vapor pressure and high retentivity, and when applied to a paper sachet, the scent remains for more than about 6 hours. The terms \u201ctop note\u201d, \u201cmiddle note\u201d, and \u201cbase note\u201d are recognized by those skilled in the art of fragrance-containing compositions. See, U.S. Pat. No. 6,013,618 of Morelli, which is incorporated herein by reference in its entirety."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Scientific Holdings LLC", "compound_ref_verbatim": null, "confidence": 0.55, "construct": {"method_text_verbatim": "At least the following methods are available for use in the present disclosure. Human panels have been trained to evaluate odors, such where the odors had the names, grassy green, green spicy, sweet, seasoned, sharp, soupy, mellow, metallic, fragrant fruity, cardboard-like, and complex (Kurobayashi et al (2006) Biosci. Biotechnol. Biochem. 70:958-965). The Kurobayashi et al, supra, study included detection of odor of terpenes, e.g., myrcene. Human panels have been trained to evaluate the level of odorants, including terpenes (linalool; L-carvone) on a scale of zero (extremely mild) to ten (extremely intense). Odorants were delivered to human subjects using an air stream. The subjects receiving the odorants, and providing subjective responses on odor intensity, also provided objective responses using electroolfactograms (EOG). The EOG test involved placing electrodes on the contralateral bridge of the nose, earlobe, and mastoids.", "panel_size": null, "property_name": "odor_intensity", "scale": "numeric_unknown", "substrate": null, "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "958-965", "patent_id": "US20250243426A1", "provenance": {"citation": "US20250243426A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20250243426A1/en"}, "pub_date": "2025-03-18", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:84", "units": null, "verbatim_quote": "At least the following methods are available for use in the present disclosure. Human panels have been trained to evaluate odors, such where the odors had the names, grassy green, green spicy, sweet, seasoned, sharp, soupy, mellow, metallic, fragrant fruity, cardboard-like, and complex (Kurobayashi et al (2006) Biosci. Biotechnol. Biochem. 70:958-965). The Kurobayashi et al, supra, study included detection of odor of terpenes, e.g., myrcene. Human panels have been trained to evaluate the level of odorants, including terpenes (linalool; L-carvone) on a scale of zero (extremely mild) to ten (extremely intense). Odorants were delivered to human subjects using an air stream. The subjects receiving the odorants, and providing subjective responses on odor intensity, also provided objective responses using electroolfactograms (EOG). The EOG test involved placing electrodes on the contralateral bridge of the nose, earlobe, and mastoids."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Scientific Holdings LLC", "compound_ref_verbatim": null, "confidence": 0.6, "construct": {"method_text_verbatim": "The present disclosure provides terpene compositions that contain individual terpenes with a high volatility and low substantivity. Chemicals with a high volatility and low substantivity are used to give an initial burst of characters, such as light, fresh, fruity, citrus, green or floral, which are detected soon after application. Such materials are referred to, by the artisan skilled in the field of fragrances as \u201ctop notes\u201d. Less volatile, and more substantive, chemicals, at least in perfumes, are used to give characters such as musk, sweet, balsamic, spicy, woody or heavy floral to the fragrance oil which, although may also be detected soon after application, also last for longer. The skilled artisan refers to these materials as \u201cmiddle notes\u201d or \u201cbase notes\u201d. The skilled artisan can blend perfume raw materials so that the resultant fragrance oils have the desired overall fragrance character profile (see U.S. Pat. No. 7,208,464 of Heltovics, which is incorporated herein by referenc", "panel_size": null, "property_name": "substantivity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["2 hours", "6 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "2 hours; 6 hours", "patent_id": "US20250243426A1", "provenance": {"citation": "US20250243426A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20250243426A1/en"}, "pub_date": "2025-03-18", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:94", "units": "hours", "verbatim_quote": "The present disclosure provides terpene compositions that contain individual terpenes with a high volatility and low substantivity. Chemicals with a high volatility and low substantivity are used to give an initial burst of characters, such as light, fresh, fruity, citrus, green or floral, which are detected soon after application. Such materials are referred to, by the artisan skilled in the field of fragrances as \u201ctop notes\u201d. Less volatile, and more substantive, chemicals, at least in perfumes, are used to give characters such as musk, sweet, balsamic, spicy, woody or heavy floral to the fragrance oil which, although may also be detected soon after application, also last for longer. The skilled artisan refers to these materials as \u201cmiddle notes\u201d or \u201cbase notes\u201d. The skilled artisan can blend perfume raw materials so that the resultant fragrance oils have the desired overall fragrance character profile (see U.S. Pat. No. 7,208,464 of Heltovics, which is incorporated herein by reference in its entirety). \u201cTop note\u201d fragrances are \u201cfragrances having a high vapor pressure, and when applied to a paper sachet, vaporization takes place within 2 hours, and no scent remains. \u201cMiddle note\u201d fragrances are \u201cfragrances having a medium vapor pressure, and when applied to a paper sachet, the scent remains from about 2 to about 6 hours. \u201cBase note\u201d fragrances are fragrances having a low vapor pressure and high retentivity, and when applied to a paper sachet, the scent remains for more than about 6 hours. The terms \u201ctop note\u201d, \u201cmiddle note\u201d, and \u201cbase note\u201d are recognized by those skilled in the art of fragrance-containing compositions. See, U.S. Pat. No. 6,013,618 of Morelli, which is incorporated herein by reference in its entirety."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Werc Shop LLC", "compound_ref_verbatim": null, "confidence": 0.55, "construct": {"method_text_verbatim": "At least the following methods are available for use in the present disclosure. Human panels have been trained to evaluate odors, such where the odors had the names, grassy green, green spicy, sweet, seasoned, sharp, soupy, mellow, metallic, fragrant fruity, cardboard-like, and complex (Kurobayashi et al (2006) Biosci. Biotechnol. Biochem. 70:958-965). The Kurobayashi et al, supra, study included detection of odor of terpenes, e.g., myrcene. Human panels have been trained to evaluate the level of odorants, including terpenes (linalool; L-carvone) on a scale of zero (extremely mild) to ten (extremely intense). Odorants were delivered to human subjects using an air stream. The subjects receiving the odorants, and providing subjective responses on odor intensity, also provided objective responses using electroolfactograms (EOG). The EOG test involved placing electrodes on the contralateral bridge of the nose, earlobe, and mastoids.", "panel_size": null, "property_name": "odor_intensity", "scale": "numeric_unknown", "substrate": null, "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "958-965", "patent_id": "US20210071105A1", "provenance": {"citation": "US20210071105A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20210071105A1/en"}, "pub_date": "2020-08-25", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:84", "units": null, "verbatim_quote": "At least the following methods are available for use in the present disclosure. Human panels have been trained to evaluate odors, such where the odors had the names, grassy green, green spicy, sweet, seasoned, sharp, soupy, mellow, metallic, fragrant fruity, cardboard-like, and complex (Kurobayashi et al (2006) Biosci. Biotechnol. Biochem. 70:958-965). The Kurobayashi et al, supra, study included detection of odor of terpenes, e.g., myrcene. Human panels have been trained to evaluate the level of odorants, including terpenes (linalool; L-carvone) on a scale of zero (extremely mild) to ten (extremely intense). Odorants were delivered to human subjects using an air stream. The subjects receiving the odorants, and providing subjective responses on odor intensity, also provided objective responses using electroolfactograms (EOG). The EOG test involved placing electrodes on the contralateral bridge of the nose, earlobe, and mastoids."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Werc Shop LLC", "compound_ref_verbatim": null, "confidence": 0.6, "construct": {"method_text_verbatim": "The present disclosure provides terpene compositions that contain individual terpenes with a high volatility and low substantivity. Chemicals with a high volatility and low substantivity are used to give an initial burst of characters, such as light, fresh, fruity, citrus, green or floral, which are detected soon after application. Such materials are referred to, by the artisan skilled in the field of fragrances as \u201ctop notes\u201d. Less volatile, and more substantive, chemicals, at least in perfumes, are used to give characters such as musk, sweet, balsamic, spicy, woody or heavy floral to the fragrance oil which, although may also be detected soon after application, also last for longer. The skilled artisan refers to these materials as \u201cmiddle notes\u201d or \u201cbase notes\u201d. The skilled artisan can blend perfume raw materials so that the resultant fragrance oils have the desired overall fragrance character profile (see U.S. Pat. No. 7,208,464 of Heltovics, which is incorporated herein by referenc", "panel_size": null, "property_name": "substantivity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["2 hours", "6 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "2 hours; 6 hours", "patent_id": "US20210071105A1", "provenance": {"citation": "US20210071105A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20210071105A1/en"}, "pub_date": "2020-08-25", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:96", "units": "hours", "verbatim_quote": "The present disclosure provides terpene compositions that contain individual terpenes with a high volatility and low substantivity. Chemicals with a high volatility and low substantivity are used to give an initial burst of characters, such as light, fresh, fruity, citrus, green or floral, which are detected soon after application. Such materials are referred to, by the artisan skilled in the field of fragrances as \u201ctop notes\u201d. Less volatile, and more substantive, chemicals, at least in perfumes, are used to give characters such as musk, sweet, balsamic, spicy, woody or heavy floral to the fragrance oil which, although may also be detected soon after application, also last for longer. The skilled artisan refers to these materials as \u201cmiddle notes\u201d or \u201cbase notes\u201d. The skilled artisan can blend perfume raw materials so that the resultant fragrance oils have the desired overall fragrance character profile (see U.S. Pat. No. 7,208,464 of Heltovics, which is incorporated herein by reference in its entirety). \u201cTop note\u201d fragrances are \u201cfragrances having a high vapor pressure, and when applied to a paper sachet, vaporization takes place within 2 hours, and no scent remains. \u201cMiddle note\u201d fragrances are \u201cfragrances having a medium vapor pressure, and when applied to a paper sachet, the scent remains from about 2 to about 6 hours. \u201cBase note\u201d fragrances are fragrances having a low vapor pressure and high retentivity, and when applied to a paper sachet, the scent remains for more than about 6 hours. The terms \u201ctop note\u201d, \u201cmiddle note\u201d, and \u201cbase note\u201d are recognized by those skilled in the art of fragrance-containing compositions. See, U.S. Pat. No. 6,013,618 of Morelli, which is incorporated herein by reference in its entirety."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Scientific Holdings LLC", "compound_ref_verbatim": null, "confidence": 0.55, "construct": {"method_text_verbatim": "At least the following methods are available for use in the present disclosure. Human panels have been trained to evaluate odors, such where the odors had the names, grassy green, green spicy, sweet, seasoned, sharp, soupy, mellow, metallic, fragrant fruity, cardboard-like, and complex (Kurobayashi et al (2006) Biosci. Biotechnol. Biochem. 70:958-965). The Kurobayashi et al, supra, study included detection of odor of terpenes, e.g., myrcene. Human panels have been trained to evaluate the level of odorants, including terpenes (linalool; L-carvone) on a scale of zero (extremely mild) to ten (extremely intense). Odorants were delivered to human subjects using an air stream. The subjects receiving the odorants, and providing subjective responses on odor intensity, also provided objective responses using electroolfactograms (EOG). The EOG test involved placing electrodes on the contralateral bridge of the nose, earlobe, and mastoids.", "panel_size": null, "property_name": "odor_intensity", "scale": "numeric_unknown", "substrate": null, "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "958-965", "patent_id": "US20240110125A1", "provenance": {"citation": "US20240110125A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20240110125A1/en"}, "pub_date": "2023-12-05", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:86", "units": null, "verbatim_quote": "At least the following methods are available for use in the present disclosure. Human panels have been trained to evaluate odors, such where the odors had the names, grassy green, green spicy, sweet, seasoned, sharp, soupy, mellow, metallic, fragrant fruity, cardboard-like, and complex (Kurobayashi et al (2006) Biosci. Biotechnol. Biochem. 70:958-965). The Kurobayashi et al, supra, study included detection of odor of terpenes, e.g., myrcene. Human panels have been trained to evaluate the level of odorants, including terpenes (linalool; L-carvone) on a scale of zero (extremely mild) to ten (extremely intense). Odorants were delivered to human subjects using an air stream. The subjects receiving the odorants, and providing subjective responses on odor intensity, also provided objective responses using electroolfactograms (EOG). The EOG test involved placing electrodes on the contralateral bridge of the nose, earlobe, and mastoids."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Scientific Holdings LLC", "compound_ref_verbatim": null, "confidence": 0.6, "construct": {"method_text_verbatim": "The present disclosure provides terpene compositions that contain individual terpenes with a high volatility and low substantivity. Chemicals with a high volatility and low substantivity are used to give an initial burst of characters, such as light, fresh, fruity, citrus, green or floral, which are detected soon after application. Such materials are referred to, by the artisan skilled in the field of fragrances as \u201ctop notes\u201d. Less volatile, and more substantive, chemicals, at least in perfumes, are used to give characters such as musk, sweet, balsamic, spicy, woody or heavy floral to the fragrance oil which, although may also be detected soon after application, also last for longer. The skilled artisan refers to these materials as \u201cmiddle notes\u201d or \u201cbase notes\u201d. The skilled artisan can blend perfume raw materials so that the resultant fragrance oils have the desired overall fragrance character profile (see U.S. Pat. No. 7,208,464 of Heltovics, which is incorporated herein by referenc", "panel_size": null, "property_name": "substantivity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["2 hours", "6 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "2 hours; 6 hours", "patent_id": "US20240110125A1", "provenance": {"citation": "US20240110125A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20240110125A1/en"}, "pub_date": "2023-12-05", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:98", "units": "hours", "verbatim_quote": "The present disclosure provides terpene compositions that contain individual terpenes with a high volatility and low substantivity. Chemicals with a high volatility and low substantivity are used to give an initial burst of characters, such as light, fresh, fruity, citrus, green or floral, which are detected soon after application. Such materials are referred to, by the artisan skilled in the field of fragrances as \u201ctop notes\u201d. Less volatile, and more substantive, chemicals, at least in perfumes, are used to give characters such as musk, sweet, balsamic, spicy, woody or heavy floral to the fragrance oil which, although may also be detected soon after application, also last for longer. The skilled artisan refers to these materials as \u201cmiddle notes\u201d or \u201cbase notes\u201d. The skilled artisan can blend perfume raw materials so that the resultant fragrance oils have the desired overall fragrance character profile (see U.S. Pat. No. 7,208,464 of Heltovics, which is incorporated herein by reference in its entirety). \u201cTop note\u201d fragrances are \u201cfragrances having a high vapor pressure, and when applied to a paper sachet, vaporization takes place within 2 hours, and no scent remains. \u201cMiddle note\u201d fragrances are \u201cfragrances having a medium vapor pressure, and when applied to a paper sachet, the scent remains from about 2 to about 6 hours. \u201cBase note\u201d fragrances are fragrances having a low vapor pressure and high retentivity, and when applied to a paper sachet, the scent remains for more than about 6 hours. The terms \u201ctop note\u201d, \u201cmiddle note\u201d, and \u201cbase note\u201d are recognized by those skilled in the art of fragrance-containing compositions. See, U.S. Pat. No. 6,013,618 of Morelli, which is incorporated herein by reference in its entirety."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Scientific Holdings LLC", "compound_ref_verbatim": null, "confidence": 0.55, "construct": {"method_text_verbatim": "At least the following methods are available for use in the present disclosure. Human panels have been trained to evaluate odors, such where the odors had the names, grassy green, green spicy, sweet, seasoned, sharp, soupy, mellow, metallic, fragrant fruity, cardboard-like, and complex (Kurobayashi et al (2006) Biosci. Biotechnol. Biochem. 70:958-965). The Kurobayashi et al, supra, study included detection of odor of terpenes, e.g., myrcene. Human panels have been trained to evaluate the level of odorants, including terpenes (linalool; L-carvone) on a scale of zero (extremely mild) to ten (extremely intense). Odorants were delivered to human subjects using an air stream. The subjects receiving the odorants, and providing subjective responses on odor intensity, also provided objective responses using electroolfactograms (EOG). The EOG test involved placing electrodes on the contralateral bridge of the nose, earlobe, and mastoids.", "panel_size": null, "property_name": "odor_intensity", "scale": "numeric_unknown", "substrate": null, "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "958-965", "patent_id": "US20250250504A1", "provenance": {"citation": "US20250250504A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20250250504A1/en"}, "pub_date": "2025-04-24", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:84", "units": null, "verbatim_quote": "At least the following methods are available for use in the present disclosure. Human panels have been trained to evaluate odors, such where the odors had the names, grassy green, green spicy, sweet, seasoned, sharp, soupy, mellow, metallic, fragrant fruity, cardboard-like, and complex (Kurobayashi et al (2006) Biosci. Biotechnol. Biochem. 70:958-965). The Kurobayashi et al, supra, study included detection of odor of terpenes, e.g., myrcene. Human panels have been trained to evaluate the level of odorants, including terpenes (linalool; L-carvone) on a scale of zero (extremely mild) to ten (extremely intense). Odorants were delivered to human subjects using an air stream. The subjects receiving the odorants, and providing subjective responses on odor intensity, also provided objective responses using electroolfactograms (EOG). The EOG test involved placing electrodes on the contralateral bridge of the nose, earlobe, and mastoids."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Scientific Holdings LLC", "compound_ref_verbatim": null, "confidence": 0.6, "construct": {"method_text_verbatim": "The present disclosure provides terpene compositions that contain individual terpenes with a high volatility and low substantivity. Chemicals with a high volatility and low substantivity are used to give an initial burst of characters, such as light, fresh, fruity, citrus, green or floral, which are detected soon after application. Such materials are referred to, by the artisan skilled in the field of fragrances as \u201ctop notes\u201d. Less volatile, and more substantive, chemicals, at least in perfumes, are used to give characters such as musk, sweet, balsamic, spicy, woody or heavy floral to the fragrance oil which, although may also be detected soon after application, also last for longer. The skilled artisan refers to these materials as \u201cmiddle notes\u201d or \u201cbase notes\u201d. The skilled artisan can blend perfume raw materials so that the resultant fragrance oils have the desired overall fragrance character profile (see U.S. Pat. No. 7,208,464 of Heltovics, which is incorporated herein by referenc", "panel_size": null, "property_name": "substantivity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["2 hours", "6 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "2 hours; 6 hours", "patent_id": "US20250250504A1", "provenance": {"citation": "US20250250504A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20250250504A1/en"}, "pub_date": "2025-04-24", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:94", "units": "hours", "verbatim_quote": "The present disclosure provides terpene compositions that contain individual terpenes with a high volatility and low substantivity. Chemicals with a high volatility and low substantivity are used to give an initial burst of characters, such as light, fresh, fruity, citrus, green or floral, which are detected soon after application. Such materials are referred to, by the artisan skilled in the field of fragrances as \u201ctop notes\u201d. Less volatile, and more substantive, chemicals, at least in perfumes, are used to give characters such as musk, sweet, balsamic, spicy, woody or heavy floral to the fragrance oil which, although may also be detected soon after application, also last for longer. The skilled artisan refers to these materials as \u201cmiddle notes\u201d or \u201cbase notes\u201d. The skilled artisan can blend perfume raw materials so that the resultant fragrance oils have the desired overall fragrance character profile (see U.S. Pat. No. 7,208,464 of Heltovics, which is incorporated herein by reference in its entirety). \u201cTop note\u201d fragrances are \u201cfragrances having a high vapor pressure, and when applied to a paper sachet, vaporization takes place within 2 hours, and no scent remains. \u201cMiddle note\u201d fragrances are \u201cfragrances having a medium vapor pressure, and when applied to a paper sachet, the scent remains from about 2 to about 6 hours. \u201cBase note\u201d fragrances are fragrances having a low vapor pressure and high retentivity, and when applied to a paper sachet, the scent remains for more than about 6 hours. The terms \u201ctop note\u201d, \u201cmiddle note\u201d, and \u201cbase note\u201d are recognized by those skilled in the art of fragrance-containing compositions. See, U.S. Pat. No. 6,013,618 of Morelli, which is incorporated herein by reference in its entirety."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Scientific Holdings LLC", "compound_ref_verbatim": null, "confidence": 0.55, "construct": {"method_text_verbatim": "At least the following methods are available for use in the present disclosure. Human panels have been trained to evaluate odors, such where the odors had the names, grassy green, green spicy, sweet, seasoned, sharp, soupy, mellow, metallic, fragrant fruity, cardboard-like, and complex (Kurobayashi et al (2006) Biosci. Biotechnol. Biochem. 70:958-965). The Kurobayashi et al, supra, study included detection of odor of terpenes, e.g., myrcene. Human panels have been trained to evaluate the level of odorants, including terpenes (linalool; L-carvone) on a scale of zero (extremely mild) to ten (extremely intense). Odorants were delivered to human subjects using an air stream. The subjects receiving the odorants, and providing subjective responses on odor intensity, also provided objective responses using electroolfactograms (EOG). The EOG test involved placing electrodes on the contralateral bridge of the nose, earlobe, and mastoids.", "panel_size": null, "property_name": "odor_intensity", "scale": "numeric_unknown", "substrate": null, "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "958-965", "patent_id": "US20250263630A1", "provenance": {"citation": "US20250263630A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20250263630A1/en"}, "pub_date": "2025-04-24", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:85", "units": null, "verbatim_quote": "At least the following methods are available for use in the present disclosure. Human panels have been trained to evaluate odors, such where the odors had the names, grassy green, green spicy, sweet, seasoned, sharp, soupy, mellow, metallic, fragrant fruity, cardboard-like, and complex (Kurobayashi et al (2006) Biosci. Biotechnol. Biochem. 70:958-965). The Kurobayashi et al, supra, study included detection of odor of terpenes, e.g., myrcene. Human panels have been trained to evaluate the level of odorants, including terpenes (linalool; L-carvone) on a scale of zero (extremely mild) to ten (extremely intense). Odorants were delivered to human subjects using an air stream. The subjects receiving the odorants, and providing subjective responses on odor intensity, also provided objective responses using electroolfactograms (EOG). The EOG test involved placing electrodes on the contralateral bridge of the nose, earlobe, and mastoids."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Scientific Holdings LLC", "compound_ref_verbatim": null, "confidence": 0.6, "construct": {"method_text_verbatim": "The present disclosure provides terpene compositions that contain individual terpenes with a high volatility and low substantivity. Chemicals with a high volatility and low substantivity are used to give an initial burst of characters, such as light, fresh, fruity, citrus, green or floral, which are detected soon after application. Such materials are referred to, by the artisan skilled in the field of fragrances as \u201ctop notes\u201d. Less volatile, and more substantive, chemicals, at least in perfumes, are used to give characters such as musk, sweet, balsamic, spicy, woody or heavy floral to the fragrance oil which, although may also be detected soon after application, also last for longer. The skilled artisan refers to these materials as \u201cmiddle notes\u201d or \u201cbase notes\u201d. The skilled artisan can blend perfume raw materials so that the resultant fragrance oils have the desired overall fragrance character profile (see U.S. Pat. No. 7,208,464 of Heltovics, which is incorporated herein by referenc", "panel_size": null, "property_name": "substantivity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["2 hours", "6 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "2 hours; 6 hours", "patent_id": "US20250263630A1", "provenance": {"citation": "US20250263630A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20250263630A1/en"}, "pub_date": "2025-04-24", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:95", "units": "hours", "verbatim_quote": "The present disclosure provides terpene compositions that contain individual terpenes with a high volatility and low substantivity. Chemicals with a high volatility and low substantivity are used to give an initial burst of characters, such as light, fresh, fruity, citrus, green or floral, which are detected soon after application. Such materials are referred to, by the artisan skilled in the field of fragrances as \u201ctop notes\u201d. Less volatile, and more substantive, chemicals, at least in perfumes, are used to give characters such as musk, sweet, balsamic, spicy, woody or heavy floral to the fragrance oil which, although may also be detected soon after application, also last for longer. The skilled artisan refers to these materials as \u201cmiddle notes\u201d or \u201cbase notes\u201d. The skilled artisan can blend perfume raw materials so that the resultant fragrance oils have the desired overall fragrance character profile (see U.S. Pat. No. 7,208,464 of Heltovics, which is incorporated herein by reference in its entirety). \u201cTop note\u201d fragrances are \u201cfragrances having a high vapor pressure, and when applied to a paper sachet, vaporization takes place within 2 hours, and no scent remains. \u201cMiddle note\u201d fragrances are \u201cfragrances having a medium vapor pressure, and when applied to a paper sachet, the scent remains from about 2 to about 6 hours. \u201cBase note\u201d fragrances are fragrances having a low vapor pressure and high retentivity, and when applied to a paper sachet, the scent remains for more than about 6 hours. The terms \u201ctop note\u201d, \u201cmiddle note\u201d, and \u201cbase note\u201d are recognized by those skilled in the art of fragrance-containing compositions. See, U.S. Pat. No. 6,013,618 of Morelli, which is incorporated herein by reference in its entirety."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.6, "construct": {"method_text_verbatim": "There are at least one of several drawbacks to the above described classical formulation approach. Firstly, classification of fragrance materials by their characters is subjective and therefore results in inconsistency in the fragrance profile under classical fragrance pyramid construction rules. Secondly, the perceived intensity of the fragrance profile of the conventional perfume compositions, particularly those characters attributable to the more volatile fragrance materials, decreases rapidly over time due to their quick evaporation. Accordingly, conventional perfume compositions will typically change their overall fragrance profile over time. This is a problem because it is desirable to maintain \"fragrance profile fidelity\" over time. In other words, it is desirable to maintain the same or substantively similar fragrance profile for a commercial fragrance over time, particularly over long periods of time (at least 4 hrs, 6 hrs, or even 8 hours after application). Thirdly, with the", "panel_size": null, "property_name": "fragrance_intensity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["4 hrs", "6 hrs", "8 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "4 hrs; 6 hrs; 8 hours", "patent_id": "EP3141239A1", "provenance": {"citation": "EP3141239A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3141239A1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:5", "units": "hours", "verbatim_quote": "There are at least one of several drawbacks to the above described classical formulation approach. Firstly, classification of fragrance materials by their characters is subjective and therefore results in inconsistency in the fragrance profile under classical fragrance pyramid construction rules. Secondly, the perceived intensity of the fragrance profile of the conventional perfume compositions, particularly those characters attributable to the more volatile fragrance materials, decreases rapidly over time due to their quick evaporation. Accordingly, conventional perfume compositions will typically change their overall fragrance profile over time. This is a problem because it is desirable to maintain \"fragrance profile fidelity\" over time. In other words, it is desirable to maintain the same or substantively similar fragrance profile for a commercial fragrance over time, particularly over long periods of time (at least 4 hrs, 6 hrs, or even 8 hours after application). Thirdly, with the classical fragrance pyramid construction, the possible types of fragrance profiles have been somewhat limited. The consequence of using base notes at high levels is that many fragrance dry-downs appear repetitive, boring, non-memorable and uninteresting to consumers. However, if base notes are reduced or excluded then the fragrance intensity weakens over time and does not last for a sufficient duration. Lastly, it is generally accepted that some consumers desire prolonged intensity of select characters, particularly the floral, spicy or aromatic characters derived from the heart notes. Unfortunately, the consequence of using high levels of base notes is that they may impart particularly undesirable characters, such as for example, musky, woody, ambery, warm and sweet, which overpower and dominate the more desirable fragrance characters over time, particular over long periods of time. Thus, the unique challenge remains of selectively extending the more desirable characters attributable from the heart and/or top notes, particularly the heart notes, and even more particularly extending these desirable characters over long periods of time."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.6, "construct": {"method_text_verbatim": "Thus, it is an advantage of the present invention to provide new rules for objectively classifying fragrance materials according to their volatility using their their vapor pressures defined at suitable temperature, instead of their characters. The new rules operate irrespective of perfumers performing the classification. In particular, the new rules classify the fragrance materials into low, moderate or high volatile fragrance materials for formulating into fragrance mixtures, particularly ones having a diamond construction. It is a further advantage of the present invention to provide compositions having improved fidelity to the perceived fragrance profile over time. It is yet a further advantage to provide a composition, wherein the character attributable to moderate and high volatile fragrance materials, particularly the moderate volatile fragrance materials, remains significantly consistent from its initial impression to the end. It is yet a further advantage to provide compositio", "panel_size": null, "property_name": "longevity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["8 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "8 hours", "patent_id": "EP3141239A1", "provenance": {"citation": "EP3141239A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3141239A1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:13", "units": "hours", "verbatim_quote": "Thus, it is an advantage of the present invention to provide new rules for objectively classifying fragrance materials according to their volatility using their their vapor pressures defined at suitable temperature, instead of their characters. The new rules operate irrespective of perfumers performing the classification. In particular, the new rules classify the fragrance materials into low, moderate or high volatile fragrance materials for formulating into fragrance mixtures, particularly ones having a diamond construction. It is a further advantage of the present invention to provide compositions having improved fidelity to the perceived fragrance profile over time. It is yet a further advantage to provide a composition, wherein the character attributable to moderate and high volatile fragrance materials, particularly the moderate volatile fragrance materials, remains significantly consistent from its initial impression to the end. It is yet a further advantage to provide compositions having improved longevity of the perceived fragrance profile, preferably the characters attributable from the moderate or high volatile fragrance materials, particularly the moderate volatile fragrance material. It is yet a further advantage to provide compositions having stable quality of end product ( e.g., fragrance profile, visual appearance) substantially comparable to the classical fragrance pyramid three-tiered structure, preferably even after three months storage at 40 \u00b0C. It is yet a further advantage to be able to create new to the world fragrance profiles wherein one, or several, well-recognized moderate volatile fragrance material characters, are maintained over time, preferably for long periods of time ( e.g., greater than 4, 6, or even 8 hours)."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.85, "construct": {"method_text_verbatim": "The present invention provides a method for imparting, intensifying, or modifying an odour on human skin or human hair, comprising applying to human skin and/or human hair the composition of the present invention. It is preferred that the method is for imparting, intensifying or modifying the longevity of a floral character or aromatic/spicy character on human skin or human hair, wherein the perceived intensity of the floral character or aromatic/spicy character at 1 hr, 2 hrs, 3 hrs or 6 hrs after application is greater than a control composition that does not include the substantially non-odorous fragrance modulator as determined by the panel method as disclosed herein.", "panel_size": null, "property_name": "longevity", "scale": "hours_or_timepoint", "substrate": ["hair", "skin"], "time_points": ["1 hr", "2 hrs", "3 hrs", "6 hrs"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "1 hr; 2 hrs; 3 hrs; 6 hrs", "patent_id": "EP3141239A1", "provenance": {"citation": "EP3141239A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3141239A1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:107", "units": "hours", "verbatim_quote": "The present invention provides a method for imparting, intensifying, or modifying an odour on human skin or human hair, comprising applying to human skin and/or human hair the composition of the present invention. It is preferred that the method is for imparting, intensifying or modifying the longevity of a floral character or aromatic/spicy character on human skin or human hair, wherein the perceived intensity of the floral character or aromatic/spicy character at 1 hr, 2 hrs, 3 hrs or 6 hrs after application is greater than a control composition that does not include the substantially non-odorous fragrance modulator as determined by the panel method as disclosed herein."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.7, "construct": {"method_text_verbatim": "At the testing facility, 50 \u00b5L samples of the compositions and the controls are applied to glass slides and placed on a hot plate at 32 \u00b0C to represent skin temperature for varying durations. It is important that glass slides of samples that are to be later compared are prepared at the same time. The panelists are asked to evaluate the perceived fragrance profile (intensity and/or character) of each glass slide sample at a given time point. Slides are presented coded so that their identity is not known by the panelists. Within a given time point panelists evaluate the slides in a random order and are able to revisit their assessment as they work through the slides at that time point. Their assessments are recorded. In the subsequent analysis, the data for strength and character comparisons are drawn from the independent assessments carried out at a given time point. Only when using the character difference scale below are any 2 products physically directly compared to each other. Panel", "panel_size": null, "property_name": "duration", "scale": "numeric_unknown", "substrate": ["skin"], "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "6-10", "patent_id": "EP3141239A1", "provenance": {"citation": "EP3141239A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3141239A1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:1074", "units": null, "verbatim_quote": "At the testing facility, 50 \u00b5L samples of the compositions and the controls are applied to glass slides and placed on a hot plate at 32 \u00b0C to represent skin temperature for varying durations. It is important that glass slides of samples that are to be later compared are prepared at the same time. The panelists are asked to evaluate the perceived fragrance profile (intensity and/or character) of each glass slide sample at a given time point. Slides are presented coded so that their identity is not known by the panelists. Within a given time point panelists evaluate the slides in a random order and are able to revisit their assessment as they work through the slides at that time point. Their assessments are recorded. In the subsequent analysis, the data for strength and character comparisons are drawn from the independent assessments carried out at a given time point. Only when using the character difference scale below are any 2 products physically directly compared to each other. Panelists are selected from individuals who are either trained to evaluate fragrances according to the scales below or who have experience of fragrance evaluation in the industry. Typically, around 6-10 panellists are used to evaluate a given product and its control."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.55, "construct": {"method_text_verbatim": "The panelists are asked to give a score on a scale of 0 to 5 for perceived fragrance intensity according to the odour intensity scale set out in Table 4 herein below. Table 4 - Odour Intensity Scale Score Fragrance Intensity 0 None 1 Very Weak 2 Weak 3 Moderate 4 Strong 5 Very Strong", "panel_size": null, "property_name": "fragrance_intensity", "scale": "numeric_unknown", "substrate": null, "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "0 to 5", "patent_id": "EP3141239A1", "provenance": {"citation": "EP3141239A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3141239A1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:1075", "units": null, "verbatim_quote": "The panelists are asked to give a score on a scale of 0 to 5 for perceived fragrance intensity according to the odour intensity scale set out in Table 4 herein below. Table 4 - Odour Intensity Scale Score Fragrance Intensity 0 None 1 Very Weak 2 Weak 3 Moderate 4 Strong 5 Very Strong"}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": "Example 6", "confidence": 0.75, "construct": {"method_text_verbatim": "The following test is carried out to demonstrate the improved or enhanced longevity of a fragrance profile of a composition of the present invention vs. a control. In particular, the test measures the effect of a substantially non-odorous fragrance modulator on the evaporation rate of one or more fragrance materials (e.g., 10 PRMs) formulated in a composition. The evaporation response of the fragrance materials to the modulator, as a function of time, is measured through the use of gas chromatography (\"GC\"). 1. A test composition may comprise a substantially non-odorous fragrance modulator (any one of the modulators as disclosed in Tables 4(a) and 4(b)) with either: (i) a fragrance material (any one of the moderate volatile fragrance materials as disclosed in Table 2 and high volatile fragrance materials as disclosed in Table 3), or (ii) a blend of fragrance materials from Tables 2 and 3 (as disclosed as Fragrance Example 6 in Table 11). The test compositions also contain high purity e", "panel_size": null, "property_name": "longevity", "scale": "percent", "substrate": null, "time_points": ["1 hr", "2 hrs", "3 hrs", "4 hrs", "5 hrs", "6 hrs", "8 hrs", "12 hrs"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "100%; 90 to 95; 99 to 99.75; 1 hr; 2 hrs; 3 hrs; 4 hrs; 5 hrs; 6 hrs; 8 hrs; 12 hrs; 5 to 10; 25 to 40", "patent_id": "EP3141239A1", "provenance": {"citation": "EP3141239A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3141239A1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:1098", "units": "hours", "verbatim_quote": "The following test is carried out to demonstrate the improved or enhanced longevity of a fragrance profile of a composition of the present invention vs. a control. In particular, the test measures the effect of a substantially non-odorous fragrance modulator on the evaporation rate of one or more fragrance materials (e.g., 10 PRMs) formulated in a composition. The evaporation response of the fragrance materials to the modulator, as a function of time, is measured through the use of gas chromatography (\"GC\"). 1. A test composition may comprise a substantially non-odorous fragrance modulator (any one of the modulators as disclosed in Tables 4(a) and 4(b)) with either: (i) a fragrance material (any one of the moderate volatile fragrance materials as disclosed in Table 2 and high volatile fragrance materials as disclosed in Table 3), or (ii) a blend of fragrance materials from Tables 2 and 3 (as disclosed as Fragrance Example 6 in Table 11). The test compositions also contain high purity ethanol, such as Hayman 100%EP/BP grade, and deionized water. Samples test compositions are provided in Tables 19(a)-19(b). All of the ingredients are admixed until evenly distributed in the test compositions. 2. A control composition to the test composition described in 1 above, without the substantially non-odorous fragrance modulator is made in a similar manner to Step 1, except that the missing substantially non-odorous modulator is replaced by deionized water. Sample control compositions are provided in Tables 19(a)-19(b). 3. An internal standard is needed to correct for variations of the amount of composition dispensed in the evaporation test as well as loss during the GC analysis. The internal standard has a vapor pressure of less than 0.001 Torr (0.000133 kPa) at 25 \u00b0C and is soluble in the composition and fragrance material. A suitable non-limiting example of an internal standard is triethyl citrate. The internal standard and fragrance material are admixed until evenly distributed at a level of 90 to 95 parts by weight of fragrance material and the required amount of internal standard to reach 100 parts. This mixture is then use to prepare the sample compositions in Step 1 and 2. Alternatively, the internal standard and test or control composition are admixed until evenly distributed at a level of 99 to 99.75 parts by weight of composition and the required amount of internal standard to reach 100 parts. This resultant solution is used in subsequent steps. 4. A hotplate is set to a temperature of 32 \u00b0C. An aluminum container, such as TA Instruments T-Zero \u2122 pan, is placed on the hotplate. 20 \u00b5L of the test or control composition is introduced in the aluminum container using a micropipette. Alternatively, the aluminum container may be filled with the test or control composition to its full capacity. The time at which this takes place is determined to be time zero ( i.e., T = 0). Multiple aluminum containers are prepared and left at the set temperature for pre-determined periods of time, such as for example 30 mins, 1 hr, 2 hrs, 3 hrs, 4 hrs, 5 hrs, 6 hrs, 8 hrs and up to 12 hrs. 5. The aluminum container is removed from the hotplate at the end of the pre-determined time period and transferred by being inserted into a 4 mL glass vial already containing at least 2 mL of highly volatile solvent, such as high purity ethanol or hexane. 6. The glass vial is mixed using a Heidolph multi REAX shaker, or equivalent, for 5 to 10 mins to extract the fragrance materials into the solvent phase. 1.5 mL of the resultant solution is transferred to a 2 mL GC vial. 7. The GC vial is analysed on an Agilent GC system 6890 equipped with an autosampler, or equivalent. A GC column such as a DB-5MS, Rxi-5 SilMS model or equivalent phase, with a length of 30 m, an inner diameter of 0.25 mm and a film thickness of 1 \u00b5m is used. The GC parameters are set to the values indicated as follows: Table 5(iii) - GC Parameters Injector temperature: 270 \u00b0C Initial gas velocity: 25 to 40 cm/sec (for Helium as the carrier gas) Initial oven temperature: 50 \u00b0C Temperature ramp: 8 \u00b0C/min Final oven temperature: 310 \u00b0C Gas chromatography with flame ionization detection (\"FID\") or with mass spectrometry (\"MS\") can be used for the identification and quantification of fragrance material in the compositions. Either detection system can be used in conjunction with GC. The column dimensions as well as GC settings described in this method, such as injector temperature, carrier gas velocity, temperature ramp and final oven temperature can be adjusted to optimize the response of the fragrance material and internal standard being monitored. The detection system settings, such as FID gas flows and temperature or MS parameters, should be optimized by a trained analyst to enable the precise detection and quantification of the analytes of interest. 8. The peak area of the fragrance material and internal standard are recorded. The peak area ratio of the fragrance material and the internal standard is calculated at each time point for each sample composition. The % of non-evaporated fragrance material remaining from T = 0 is calculated at each time point for each sample composition. The % fragrance material remaining in each composition is plotted to give an evaporation profile over time. This is done for both the test and control compositions. Significance is determined by comparison of the evaporation profile for the same fragrance material or same fragrance mixture in the test and control compositions."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": "example 10", "confidence": 0.9, "construct": {"method_text_verbatim": "The following test is carried out to demonstrate the character retention over time of a fragrance composition of the present invention vs. a control. It is necessary for the test and control samples to be run at approximately the same time to ensure that ambient conditions are the same. The test measures the presence of one or more fragrance materials in the headspace formed in a sealed vial by the test composition, after set evaporation times. The fragrance profile in the headspace is measured at specific time points through the use of headspace (\"HS\") gas chromatography (\"GC\"). 1. The test and control compositions as described in the Example section are used for the evaluation. 2. Capillaries of about 2 cm to 3.5 cm, with one sealed end are cut from a Sigma Aldrich \"Stuart\u2122 melting point tube\" product code Z673269, or equivalent. A suitable fixed volume chosen between 50 and 200 \u00b5L of the composition is pipetted into the well of a VWR Tissue Culture 96 F well plate, or equivalent. Th", "panel_size": null, "property_name": "headspace_concentration_or_intensity", "scale": "hours_or_timepoint", "substrate": ["headspace"], "time_points": ["1 hr", "2 hrs", "3 hrs", "4 hrs", "5 hrs", "6 hrs"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "1 hr; 2 hrs; 3 hrs; 4 hrs; 5 hrs; 6 hrs; 50/30; 20 to 40", "patent_id": "EP3141239A1", "provenance": {"citation": "EP3141239A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3141239A1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:1104", "units": "hours", "verbatim_quote": "The following test is carried out to demonstrate the character retention over time of a fragrance composition of the present invention vs. a control. It is necessary for the test and control samples to be run at approximately the same time to ensure that ambient conditions are the same. The test measures the presence of one or more fragrance materials in the headspace formed in a sealed vial by the test composition, after set evaporation times. The fragrance profile in the headspace is measured at specific time points through the use of headspace (\"HS\") gas chromatography (\"GC\"). 1. The test and control compositions as described in the Example section are used for the evaluation. 2. Capillaries of about 2 cm to 3.5 cm, with one sealed end are cut from a Sigma Aldrich \"Stuart\u2122 melting point tube\" product code Z673269, or equivalent. A suitable fixed volume chosen between 50 and 200 \u00b5L of the composition is pipetted into the well of a VWR Tissue Culture 96 F well plate, or equivalent. The sealed end of the glass capillary is dipped into the filled well and left for at least 15 secs to wet the surface of the glass. Care must be taken not to contact the glass capillary with the sides of the well by maintaining it straight and approximately in the center of the well. 3. The glass capillary is then removed from the well and inverted or transferred onto a stable surface or into a holder and allowed to evaporate at ambient conditions for a set period of time. A windshield may be used to reduce high air turbulence. 4. The glass capillary is then introduced into an empty 20 mL HS vial, which is immediately closed with a PTFE cap. The time at which this takes place is determined to be time T = initial ( i.e., T = 10 mins). 5. Multiple glass capillaries are prepared in the same way and left to evaporate at ambient temperature for pre-detennined periods of time, such as for example 10, 15, 30 mins, 1 hr, 2 hrs, 3 hrs, 4 hrs, 5 hrs, and up to 6 hrs, before being introduced to the headspace vial and sealed. 6. The HS vial is then analysed on an Agilent GC system 6890 equipped with a Gerstel MPS 2 autosampler, or equivalent, capable of performing SPME injections. A SPME fiber assembly DVB/CAR/PDMS (50/30 \u00b5m, 1 cm length) is required. A GC column such as a DB-5MS, ZB-5MSi models, or equivalent phase, with a length of 30 m, an inner diameter of 0.25 mm and a film thickness of 1 \u00b5m is used. 7. The SPME HS parameters are set to the values indicated as follows: Table 5(iv) - SPME Parameters Incubation chamber temperature: 40 \u00b0C Incubation time: 20 mins Agitation of sample 250 RPM Extraction time 5 mins Desorption time 2 mins 8. The GC parameters are set to the values indicated as follows: Table 5(v) - GC Parameters Injector temperature: 270 \u00b0C Initial gas velocity: 20 to 40 cm/sec (for Helium as the carrier gas) Initial oven temperature: 45\u00b0C with 2 mins Hold Time Temperature ramp 1: 30 \u00b0C/min Temperature 1: 80 \u00b0C Temperature ramp 2: 8\u00b0C/min Final temperature: 300 \u00b0C Gas chromatography with flame ionization detection (\"FID\") or with mass spectrometry (\"MS\") can be used for the identification and quantification of fragrance material in the compositions. Either detection system can be used in conjunction with GC. The column dimensions as well as GC settings described in this method, such as injector temperature, carrier gas velocity, temperature ramp and final oven temperature can be adjusted to optimize the response of the fragrance material being monitored. The detection system settings, such as FID gas flows and temperature or MS parameters, should be optimized by a trained analyst to enable the precise detection and identification of the analytes of interest. 9. A qualitative assessment of the chromatograms obtained is performed by comparing the peak height of the fragrance materials and overall chromatogram at time T = 10 mins to other time points. A dotted line is drawn around an estimated retention time where fragrance materials with a vapour pressure of 0.001 Torr or less (0.000133 kPa or less) elute during the analysis. The difference between the peaks present at each measured time point for the test and control compositions provides evidence of the retention of the character of the fragrance over time. 10. This test set-up is designed to enable the collection of the headspace in a manner that does not saturate the SPME fiber. If the fiber is saturated it does not provide an accurate analysis of the headspace composition. Therefore the quantity of liquid and the evaporation surface area are very different from those in the olfactive evaluation of the same samples. For this reason it is not possible to compare directly the evaporation time frames used in the 2 experiments. It is expected that the evaporation profile is much faster in this headspace experiments compared to the olfactive evaluations."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.7, "construct": {"method_text_verbatim": "Compositions disclosed in Tables 18(a)-18(d), 20, 21, and 22(a)-22(d) are applied to glass slides in accordance with the protocol described in the Method Section and a panel of 6-10 experienced panelists evaluate the perceived fragrance profile at initial time 0, then at various time points, typically 1 hour, 2 hours, 3 hours, 4 hours and 6 hours post application. Panelists are asked to score the compositions for the longevity and/or fidelity of the fragrance profile on a scale of 0 to 5, wherein 0 represents a no fragrance is detected and 5 represents a very strong fragrance intensity is detected. The results of the panelists are then averaged and discussed below.", "panel_size": null, "property_name": "fragrance_intensity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["1 hour", "2 hours", "3 hours", "4 hours", "6 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "6-10; 1 hour; 2 hours; 3 hours; 4 hours; 6 hours; 0 to 5", "patent_id": "EP3141239A1", "provenance": {"citation": "EP3141239A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3141239A1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:1576", "units": "hours", "verbatim_quote": "Compositions disclosed in Tables 18(a)-18(d), 20, 21, and 22(a)-22(d) are applied to glass slides in accordance with the protocol described in the Method Section and a panel of 6-10 experienced panelists evaluate the perceived fragrance profile at initial time 0, then at various time points, typically 1 hour, 2 hours, 3 hours, 4 hours and 6 hours post application. Panelists are asked to score the compositions for the longevity and/or fidelity of the fragrance profile on a scale of 0 to 5, wherein 0 represents a no fragrance is detected and 5 represents a very strong fragrance intensity is detected. The results of the panelists are then averaged and discussed below."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.7, "construct": {"method_text_verbatim": "Figure 2 shows the fragrance intensity profile of Composition A9 (as disclosed in Table 22(c)) as evaluated by 10 panelists, which comprises the substantially non-odorous fragrance modulator Bis-methoxy PEG-13 PEG-438/PPG-110 SMDI Copolymer ( i.e., Expert Gel \u00ae 56) and the single fragrance material Indocolore. Addition of the substantially non-odorous fragrance modulator (Expert Gel \u00ae 56) maintains the intensity of the fragrance material for up to at least 6 hours whilst the control, Composition B9, in the absence of the substantially non-odorous fragrance modulator, drops in fragrance intensity profile much more over this time. The substantially non-odorous fragrance modulator acts to maintain the continued initial evaporation over time of the fragrance material. Statistical analysis using the Tukey correction for multiple comparisons confirms the statistically significant difference at 1, 3 and 6 hours (p < 0.0001) at 95% significance level ( i.e., p < 0.05) at all these time points.", "panel_size": 10, "property_name": "fragrance_intensity", "scale": "percent", "substrate": null, "time_points": ["6 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "6 hours", "patent_id": "EP3141239A1", "provenance": {"citation": "EP3141239A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3141239A1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:1577", "units": "hours", "verbatim_quote": "Figure 2 shows the fragrance intensity profile of Composition A9 (as disclosed in Table 22(c)) as evaluated by 10 panelists, which comprises the substantially non-odorous fragrance modulator Bis-methoxy PEG-13 PEG-438/PPG-110 SMDI Copolymer ( i.e., Expert Gel \u00ae 56) and the single fragrance material Indocolore. Addition of the substantially non-odorous fragrance modulator (Expert Gel \u00ae 56) maintains the intensity of the fragrance material for up to at least 6 hours whilst the control, Composition B9, in the absence of the substantially non-odorous fragrance modulator, drops in fragrance intensity profile much more over this time. The substantially non-odorous fragrance modulator acts to maintain the continued initial evaporation over time of the fragrance material. Statistical analysis using the Tukey correction for multiple comparisons confirms the statistically significant difference at 1, 3 and 6 hours (p < 0.0001) at 95% significance level ( i.e., p < 0.05) at all these time points."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.7, "construct": {"method_text_verbatim": "Figure 3 shows the fragrance intensity profile of Composition C9 (as disclosed in Table 22(c)) as evaluated by 9 panelists, which comprises the substantially non-odorous fragrance modulator propyl {4-[2-(diethylamino)-2-oxoethoxy]-3-methoxyphenyl}acetate ( i.e ., Kolliphor \u00ae EL) and the single fragrance material Dimethyl Benzyl Carbinol. Addition of the substantially non-odorous fragrance modulator (Kolliphor \u00ae EL) maintains the intensity of the fragrance material for up to at least 6 hours whilst the control, Composition D9, in the absence of the substantially non-odorous fragrance modulator, drops in fragrance intensity profile much more over this time. The substantially non-odorous fragrance modulator acts to maintain the reduced rate of evaporation over time of the fragrance material. Statistical analysis using the Tukey correction for multiple comparisons confirms the statistically significant difference at 1 hour (p < 0.0001), 3 hours (p = 0.0265) and 6 hours (p = 0.0388) at 95% ", "panel_size": 9, "property_name": "fragrance_intensity", "scale": "percent", "substrate": null, "time_points": ["6 hours", "1 hour", "3 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "6 hours; 1 hour; 3 hours", "patent_id": "EP3141239A1", "provenance": {"citation": "EP3141239A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3141239A1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:1578", "units": "hours", "verbatim_quote": "Figure 3 shows the fragrance intensity profile of Composition C9 (as disclosed in Table 22(c)) as evaluated by 9 panelists, which comprises the substantially non-odorous fragrance modulator propyl {4-[2-(diethylamino)-2-oxoethoxy]-3-methoxyphenyl}acetate ( i.e ., Kolliphor \u00ae EL) and the single fragrance material Dimethyl Benzyl Carbinol. Addition of the substantially non-odorous fragrance modulator (Kolliphor \u00ae EL) maintains the intensity of the fragrance material for up to at least 6 hours whilst the control, Composition D9, in the absence of the substantially non-odorous fragrance modulator, drops in fragrance intensity profile much more over this time. The substantially non-odorous fragrance modulator acts to maintain the reduced rate of evaporation over time of the fragrance material. Statistical analysis using the Tukey correction for multiple comparisons confirms the statistically significant difference at 1 hour (p < 0.0001), 3 hours (p = 0.0265) and 6 hours (p = 0.0388) at 95% significance level ( i.e., p < 0.05) at all these time points."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.7, "construct": {"method_text_verbatim": "Figure 4 shows the fragrance intensity profile of Composition E9 (as disclosed in Table 22(c)) as evaluated by 9 panelists, which comprises the substantially non-odorous fragrance modulator propyl {4-[2-(diethylamino)-2-oxoethoxy]-3-methoxyphenyl}acetate ( i.e ., Kolliphor \u00ae EL) and the single fragrance material Eugenol. Addition of the substantially non-odorous fragrance modulator (Kolliphor \u00ae EL) maintains the intensity of the fragrance material for up to at least 6 hours whilst the control, Composition F9, in the absence of the substantially non-odorous fragrance modulator, drops in fragrance intensity profile much more over this time. The substantially non-odorous fragrance modulator acts to supress the initial display of Eugenol and then maintains that continued initial evaporation over time. Statistical analysis using the Tukey correction for multiple comparisons confirms the statistically significant difference at 0 hours (p = 0.0025), 1 hour (p < 0.0001), 3 hours (p < 0.0001) a", "panel_size": 9, "property_name": "fragrance_intensity", "scale": "percent", "substrate": null, "time_points": ["6 hours", "0 hours", "1 hour", "3 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "6 hours; 0 hours; 1 hour; 3 hours", "patent_id": "EP3141239A1", "provenance": {"citation": "EP3141239A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3141239A1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:1579", "units": "hours", "verbatim_quote": "Figure 4 shows the fragrance intensity profile of Composition E9 (as disclosed in Table 22(c)) as evaluated by 9 panelists, which comprises the substantially non-odorous fragrance modulator propyl {4-[2-(diethylamino)-2-oxoethoxy]-3-methoxyphenyl}acetate ( i.e ., Kolliphor \u00ae EL) and the single fragrance material Eugenol. Addition of the substantially non-odorous fragrance modulator (Kolliphor \u00ae EL) maintains the intensity of the fragrance material for up to at least 6 hours whilst the control, Composition F9, in the absence of the substantially non-odorous fragrance modulator, drops in fragrance intensity profile much more over this time. The substantially non-odorous fragrance modulator acts to supress the initial display of Eugenol and then maintains that continued initial evaporation over time. Statistical analysis using the Tukey correction for multiple comparisons confirms the statistically significant difference at 0 hours (p = 0.0025), 1 hour (p < 0.0001), 3 hours (p < 0.0001) and 6 hours (p < 0.0001) at 95% significance level ( i.e., p < 0.05) at all time points."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.7, "construct": {"method_text_verbatim": "Figure 5 shows the fragrance intensity profile of Composition G9 (as disclosed in Table 22(c)) as evaluated by 9 panelists, which comprises the substantially non-odorous fragrance modulator propyl {4-[2-(diethylamino)-2-oxoethoxy]-3-methoxyphenyl}acetate ( i.e ., Kolliphor \u00ae EL) and the single fragrance material Phenethyl alcohol (PEA). Addition of the substantially non-odorous fragrance modulator (Kolliphor \u00ae EL) maintains the intensity of the fragrance material from 1 hour to 3 hours whilst the control, Composition H9, in the absence of the substantially non-odorous fragrance modulator, drops in fragrance intensity profile over this time. The substantially non-odorous fragrance modulator acts to maintain the reduced rate of evaporation over time of the fragrance material. Statistical analysis using the Tukey correction for multiple comparisons confirms the statistically significant difference at 1 hour (p < 0.0001) at 95% significance level ( i.e., p < 0.05) and at 3 hours (p = 0.087", "panel_size": 9, "property_name": "fragrance_intensity", "scale": "percent", "substrate": null, "time_points": ["1 hour", "3 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "1 hour; 3 hours", "patent_id": "EP3141239A1", "provenance": {"citation": "EP3141239A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3141239A1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:1580", "units": "hours", "verbatim_quote": "Figure 5 shows the fragrance intensity profile of Composition G9 (as disclosed in Table 22(c)) as evaluated by 9 panelists, which comprises the substantially non-odorous fragrance modulator propyl {4-[2-(diethylamino)-2-oxoethoxy]-3-methoxyphenyl}acetate ( i.e ., Kolliphor \u00ae EL) and the single fragrance material Phenethyl alcohol (PEA). Addition of the substantially non-odorous fragrance modulator (Kolliphor \u00ae EL) maintains the intensity of the fragrance material from 1 hour to 3 hours whilst the control, Composition H9, in the absence of the substantially non-odorous fragrance modulator, drops in fragrance intensity profile over this time. The substantially non-odorous fragrance modulator acts to maintain the reduced rate of evaporation over time of the fragrance material. Statistical analysis using the Tukey correction for multiple comparisons confirms the statistically significant difference at 1 hour (p < 0.0001) at 95% significance level ( i.e., p < 0.05) and at 3 hours (p = 0.0876) at 90% significance level ( i.e., p < 0.1)."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.7, "construct": {"method_text_verbatim": "Panelists are asked to score the compositions for the intensity of the fragrance on a scale of 0 to 5, wherein 0 represents a no fragrance intensity is detected and 5 represents a very strong fragrance intensity is detected. The results of the panel test are then averaged. The results show the effect of the substantially non-odorous fragrance modulator and diamond constructed fragrance materials for any one of the inventive Compositions A1, A2, A3, A4, A5, D1, D2, D4, G1, G2, G4, J1, J2, J4, M1, and M2 on fragrance profile longevity versus control Compositions C1, C2, C3, C4, C5, F1, F2, F4, I1, I2, I4, L1, L2, L4, O1, and 02 in the absence of the substantially non-odorous modulator. Alternatively, the results show the effect of the substantially non-odorous fragrance modulator and diamond constructed fragrance materials for any one of the inventive Compositions A1, A2, A3, A4, A5, D1, D2, D4, G1, G2, G4, J1, J2, J4, M1, and M2 on fragrance profile longevity versus traditional Composit", "panel_size": null, "property_name": "fragrance_intensity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["6 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "0 to 5; 6 hours", "patent_id": "EP3141239A1", "provenance": {"citation": "EP3141239A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3141239A1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:1581", "units": "hours", "verbatim_quote": "Panelists are asked to score the compositions for the intensity of the fragrance on a scale of 0 to 5, wherein 0 represents a no fragrance intensity is detected and 5 represents a very strong fragrance intensity is detected. The results of the panel test are then averaged. The results show the effect of the substantially non-odorous fragrance modulator and diamond constructed fragrance materials for any one of the inventive Compositions A1, A2, A3, A4, A5, D1, D2, D4, G1, G2, G4, J1, J2, J4, M1, and M2 on fragrance profile longevity versus control Compositions C1, C2, C3, C4, C5, F1, F2, F4, I1, I2, I4, L1, L2, L4, O1, and 02 in the absence of the substantially non-odorous modulator. Alternatively, the results show the effect of the substantially non-odorous fragrance modulator and diamond constructed fragrance materials for any one of the inventive Compositions A1, A2, A3, A4, A5, D1, D2, D4, G1, G2, G4, J1, J2, J4, M1, and M2 on fragrance profile longevity versus traditional Compositions B1, B2, B3, B4, B5, E1, E2, E4, H1, H2, H4, K1, K2, K4, N1, and N2 in the presence of the substantially non-odorous fragrance modulator. Fragrance profile longevity, particularly intensity of the characters attributable to the volatile fragrance materials are maintained for up to at least 6 hours in the presence of the substantially non-odorous fragrance modulator whilst it drops in the absence of the substantially non-odorous fragrance modulator."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": "Example 4b", "confidence": 0.75, "construct": {"method_text_verbatim": "Figure 6 provides the fragrance intensity profile of Composition A4 (as disclosed in Table 18(d)), which comprises the substantially non-odorous fragrance modulator PPG-20 Methyl Glucose Ether ( i.e ., Glucam\u2122 P-20) and the Diamond Floral Magnifica Fragrance Example 4b. Addition of the substantially non-odorous fragrance modulator Glucam\u2122 P-20 maintains the intensity of the fragrance material for up to 6 hours. As compared to the control Composition C4, in the absence of the substantially non-odorous fragrance modulator Glucam\u2122 P-20, and comprising the Traditional Floral Magnifica Fragrance Example 4a drops in fragrance intensity over the 6 hours.", "panel_size": null, "property_name": "fragrance_intensity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["6 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "6 hours", "patent_id": "EP3141239A1", "provenance": {"citation": "EP3141239A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3141239A1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:1582", "units": "hours", "verbatim_quote": "Figure 6 provides the fragrance intensity profile of Composition A4 (as disclosed in Table 18(d)), which comprises the substantially non-odorous fragrance modulator PPG-20 Methyl Glucose Ether ( i.e ., Glucam\u2122 P-20) and the Diamond Floral Magnifica Fragrance Example 4b. Addition of the substantially non-odorous fragrance modulator Glucam\u2122 P-20 maintains the intensity of the fragrance material for up to 6 hours. As compared to the control Composition C4, in the absence of the substantially non-odorous fragrance modulator Glucam\u2122 P-20, and comprising the Traditional Floral Magnifica Fragrance Example 4a drops in fragrance intensity over the 6 hours."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": "Example 5b", "confidence": 0.75, "construct": {"method_text_verbatim": "Figure 7 provides the fragrance intensity profile of Composition A4 (as disclosed in Table 18(d)), which comprises the substantially non-odorous fragrance modulator PPG-20 Methyl Glucose Ether ( i.e ., Glucam\u2122 P-20) and the Diamond Muguesia Magnifica Fragrance Example 5b. Addition of the substantially non-odorous fragrance modulator Glucam\u2122 P-20 maintains the intensity of the fragrance material for up to 6 hours. As compared to the control Composition C4, in the absence of the substantially non-odorous fragrance modulator Glucam\u2122 P-20, and comprising the Traditional Muguesia Magnifica Fragrance Example 5a drops in fragrance intensity over the 6 hours.", "panel_size": null, "property_name": "fragrance_intensity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["6 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "6 hours", "patent_id": "EP3141239A1", "provenance": {"citation": "EP3141239A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3141239A1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:1583", "units": "hours", "verbatim_quote": "Figure 7 provides the fragrance intensity profile of Composition A4 (as disclosed in Table 18(d)), which comprises the substantially non-odorous fragrance modulator PPG-20 Methyl Glucose Ether ( i.e ., Glucam\u2122 P-20) and the Diamond Muguesia Magnifica Fragrance Example 5b. Addition of the substantially non-odorous fragrance modulator Glucam\u2122 P-20 maintains the intensity of the fragrance material for up to 6 hours. As compared to the control Composition C4, in the absence of the substantially non-odorous fragrance modulator Glucam\u2122 P-20, and comprising the Traditional Muguesia Magnifica Fragrance Example 5a drops in fragrance intensity over the 6 hours."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": "Example 4b", "confidence": 0.75, "construct": {"method_text_verbatim": "Figure 8 provides the fragrance intensity profile of Composition A2 (as disclosed in Table 18(b)), which comprises 15 wt% substantially non-odorous fragrance modulator Diisobutyl Adipate and 7 wt% Diamond Floral Magnifica Fragrance Example 4b. Addition of the substantially non-odorous fragrance modulator Diisobutyl Adipate maintains the intensity of the fragrance material for up to 6 hours. As compared to the control Composition C2, in the absence of the substantially non-odorous fragrance modulator Diisobutyl Adipate, and comprising 7 wt% Traditional Floral Magnifica Fragrance Example 4a drops in fragrance intensity over the 6 hours.", "panel_size": null, "property_name": "fragrance_intensity", "scale": "percent", "substrate": null, "time_points": ["6 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "6 hours", "patent_id": "EP3141239A1", "provenance": {"citation": "EP3141239A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3141239A1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:1584", "units": "hours", "verbatim_quote": "Figure 8 provides the fragrance intensity profile of Composition A2 (as disclosed in Table 18(b)), which comprises 15 wt% substantially non-odorous fragrance modulator Diisobutyl Adipate and 7 wt% Diamond Floral Magnifica Fragrance Example 4b. Addition of the substantially non-odorous fragrance modulator Diisobutyl Adipate maintains the intensity of the fragrance material for up to 6 hours. As compared to the control Composition C2, in the absence of the substantially non-odorous fragrance modulator Diisobutyl Adipate, and comprising 7 wt% Traditional Floral Magnifica Fragrance Example 4a drops in fragrance intensity over the 6 hours."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": "Example 5b", "confidence": 0.75, "construct": {"method_text_verbatim": "Figure 9 provides the fragrance intensity profile of Composition A2 (as disclosed in Table 18(b)), which comprises 15 wt% substantially non-odorous fragrance modulator Diisobutyl Adipate and 7 wt% Diamond Muguesia Magnifica Fragrance Example 5b. Addition of the substantially non-odorous fragrance modulator Diisobutyl Adipate maintains the intensity of the fragrance material for up to 6 hours. As compared to the control Composition C2, in the absence of the substantially non-odorous fragrance modulator Diisobutyl Adipate, and comprising 7 wt% Traditional Muguesia Magnifica Fragrance Example 5a drops in fragrance intensity over the 6 hours.", "panel_size": null, "property_name": "fragrance_intensity", "scale": "percent", "substrate": null, "time_points": ["6 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "6 hours", "patent_id": "EP3141239A1", "provenance": {"citation": "EP3141239A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3141239A1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:1585", "units": "hours", "verbatim_quote": "Figure 9 provides the fragrance intensity profile of Composition A2 (as disclosed in Table 18(b)), which comprises 15 wt% substantially non-odorous fragrance modulator Diisobutyl Adipate and 7 wt% Diamond Muguesia Magnifica Fragrance Example 5b. Addition of the substantially non-odorous fragrance modulator Diisobutyl Adipate maintains the intensity of the fragrance material for up to 6 hours. As compared to the control Composition C2, in the absence of the substantially non-odorous fragrance modulator Diisobutyl Adipate, and comprising 7 wt% Traditional Muguesia Magnifica Fragrance Example 5a drops in fragrance intensity over the 6 hours."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.6, "construct": {"method_text_verbatim": "Without wishing to be bound by theory, it is believed that the substantially non-odorous fragrance modulator acts to maintain the continued evaporation over time of the fragrance materials, particular the volatile fragrance materials. The effects of the improved fragrance profile longevity of the present invention are noticeable at, any one of, 1, 3 and 6 hours post application.", "panel_size": null, "property_name": "longevity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["6 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "6 hours", "patent_id": "EP3141239A1", "provenance": {"citation": "EP3141239A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3141239A1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:1587", "units": "hours", "verbatim_quote": "Without wishing to be bound by theory, it is believed that the substantially non-odorous fragrance modulator acts to maintain the continued evaporation over time of the fragrance materials, particular the volatile fragrance materials. The effects of the improved fragrance profile longevity of the present invention are noticeable at, any one of, 1, 3 and 6 hours post application."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.6, "construct": {"method_text_verbatim": "The test demonstrates the character retention over time of a fragrance composition. The results show the effect of the substantially non-odorous fragrance modulator and fragrance materials in a diamond construction for any one of the inventive Compositions A1, A2, A3, A4, A5, D1, D2, D4, G1, G2, G4, J1, J2, J4, M1, and M2 on fragrance profile versus control Compositions C1, C2, C3, C4, C5, F1, F2, F4, I1, I2, I4, L1, L2, L4, O1, and 02 in the absence of the substantially non-odorous fragrance modulator. Alternatively, results show the effect of the substantially non-odorous fragrance modulator and fragrance materials in a diamond construction for any one of the inventive Compositions A1, A2, A3, A4, A5, D1, D2, D4, G1, G2, G4, J1, J2, J4, M1, and M2 on fragrance profile longevity versus traditional Compositions B1, B2, B3, B4, B5, E1, E2, E4, H1, H2, H4, K1, K2, K4, N1, and N2 in the presence of the substantially non-odorous fragrance modulator. Fragrance profile fidelity, particularly", "panel_size": null, "property_name": "longevity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["1 hour"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "1 hour", "patent_id": "EP3141239A1", "provenance": {"citation": "EP3141239A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3141239A1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:1607", "units": "hours", "verbatim_quote": "The test demonstrates the character retention over time of a fragrance composition. The results show the effect of the substantially non-odorous fragrance modulator and fragrance materials in a diamond construction for any one of the inventive Compositions A1, A2, A3, A4, A5, D1, D2, D4, G1, G2, G4, J1, J2, J4, M1, and M2 on fragrance profile versus control Compositions C1, C2, C3, C4, C5, F1, F2, F4, I1, I2, I4, L1, L2, L4, O1, and 02 in the absence of the substantially non-odorous fragrance modulator. Alternatively, results show the effect of the substantially non-odorous fragrance modulator and fragrance materials in a diamond construction for any one of the inventive Compositions A1, A2, A3, A4, A5, D1, D2, D4, G1, G2, G4, J1, J2, J4, M1, and M2 on fragrance profile longevity versus traditional Compositions B1, B2, B3, B4, B5, E1, E2, E4, H1, H2, H4, K1, K2, K4, N1, and N2 in the presence of the substantially non-odorous fragrance modulator. Fragrance profile fidelity, particularly of floral characters attributable to the volatile fragrance materials are maintained for up to at least 1 hour in the presence of the substantially non-odorous fragrance modulator whilst it drops in the absence of the substantially non-odorous fragrance modulator."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.6, "construct": {"method_text_verbatim": "The composition according to any one of the preceding claims, wherein the composition maintains the perceived fragrance profile, particularly the characters attributable to the moderate volatile fragrance material and/or high volatile fragrance material, to remain substantively unchanged from application up to 2 hrs, 3 hrs, 4 hrs, 5 hrs, 6 hrs or 8 hrs after application vs. a control composition that does not include a diamond construction fragrance formulation and the substantially non-odorous fragrance modulator, as determined according to the Odour Test as described herein.", "panel_size": null, "property_name": "substantivity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["2 hrs", "3 hrs", "4 hrs", "5 hrs", "6 hrs", "8 hrs"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "2 hrs; 3 hrs; 4 hrs; 5 hrs; 6 hrs; 8 hrs", "patent_id": "EP3141239A1", "provenance": {"citation": "EP3141239A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3141239A1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "claims:15", "units": "hours", "verbatim_quote": "The composition according to any one of the preceding claims, wherein the composition maintains the perceived fragrance profile, particularly the characters attributable to the moderate volatile fragrance material and/or high volatile fragrance material, to remain substantively unchanged from application up to 2 hrs, 3 hrs, 4 hrs, 5 hrs, 6 hrs or 8 hrs after application vs. a control composition that does not include a diamond construction fragrance formulation and the substantially non-odorous fragrance modulator, as determined according to the Odour Test as described herein."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.85, "construct": {"method_text_verbatim": "The method according to claim 19, wherein the method is preferably for imparting, intensifying or modifying the longevity of a floral character on human skin or human hair, wherein the perceived intensity of the floral character at 1 hr, 2 hrs, 3 hrs or 6 hrs after application is greater than a control composition that does not include the substantially non-odorous fragrance modulator as determined by the panel method as disclosed herein, and wherein the floral character is selected from the group consisting of lavender-type note, a rose-type note, a lily of the valley-type note, a muguet-type note, a jasmine-type note, a magnolia-type note, a cyclamen-type note, a hyacinth-type note, a lilac-type note, an orange blossom-type note, a cherry blossom-type note, a peony-type note, a lotus-type note, a linden blossom-type note, an osmanthus-type note, a lilac-type note, a heliotrope-type note, a violet-type note, an orris-type note, a tiare-type note, a patchouli-type note and the like.", "panel_size": null, "property_name": "longevity", "scale": "hours_or_timepoint", "substrate": ["hair", "skin"], "time_points": ["1 hr", "2 hrs", "3 hrs", "6 hrs"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "1 hr; 2 hrs; 3 hrs; 6 hrs", "patent_id": "EP3141239A1", "provenance": {"citation": "EP3141239A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3141239A1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "claims:20", "units": "hours", "verbatim_quote": "The method according to claim 19, wherein the method is preferably for imparting, intensifying or modifying the longevity of a floral character on human skin or human hair, wherein the perceived intensity of the floral character at 1 hr, 2 hrs, 3 hrs or 6 hrs after application is greater than a control composition that does not include the substantially non-odorous fragrance modulator as determined by the panel method as disclosed herein, and wherein the floral character is selected from the group consisting of lavender-type note, a rose-type note, a lily of the valley-type note, a muguet-type note, a jasmine-type note, a magnolia-type note, a cyclamen-type note, a hyacinth-type note, a lilac-type note, an orange blossom-type note, a cherry blossom-type note, a peony-type note, a lotus-type note, a linden blossom-type note, an osmanthus-type note, a lilac-type note, a heliotrope-type note, a violet-type note, an orris-type note, a tiare-type note, a patchouli-type note and the like."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.6, "construct": {"method_text_verbatim": "There are at least one of several drawbacks to the above described classical formulation approach. Firstly, classification of fragrance materials by their characters is subjective and therefore results in inconsistency in the fragrance profile under classical fragrance pyramid construction rules. Secondly, the perceived intensity of the fragrance profile of the conventional perfume compositions, particularly those characters attributable to the more volatile fragrance materials, decreases rapidly over time due to their quick evaporation. Accordingly, conventional perfume compositions will typically change their overall fragrance profile over time. This is a problem because it is desirable to maintain \u201cfragrance profile fidelity\u201d over time. In other words, it is desirable to maintain the same or substantively similar fragrance profile for a commercial fragrance over time, particularly over long periods of time (at least 4 hrs, 6 hrs, or even 8 hours after application). Thirdly, with the", "panel_size": null, "property_name": "fragrance_intensity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["4 hrs", "6 hrs", "8 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "4 hrs; 6 hrs; 8 hours", "patent_id": "US20180180391A1", "provenance": {"citation": "US20180180391A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20180180391A1/en"}, "pub_date": "2018-01-23", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:5", "units": "hours", "verbatim_quote": "There are at least one of several drawbacks to the above described classical formulation approach. Firstly, classification of fragrance materials by their characters is subjective and therefore results in inconsistency in the fragrance profile under classical fragrance pyramid construction rules. Secondly, the perceived intensity of the fragrance profile of the conventional perfume compositions, particularly those characters attributable to the more volatile fragrance materials, decreases rapidly over time due to their quick evaporation. Accordingly, conventional perfume compositions will typically change their overall fragrance profile over time. This is a problem because it is desirable to maintain \u201cfragrance profile fidelity\u201d over time. In other words, it is desirable to maintain the same or substantively similar fragrance profile for a commercial fragrance over time, particularly over long periods of time (at least 4 hrs, 6 hrs, or even 8 hours after application). Thirdly, with the classical fragrance pyramid construction, the possible types of fragrance profiles have been somewhat limited. The consequence of using base notes at high levels is that many fragrance dry-downs appear repetitive, boring, non-memorable and un-interesting to consumers. However, if base notes are reduced or excluded then the fragrance intensity weakens over time and does not last for a sufficient duration. Lastly, it is generally accepted that some consumers desire prolonged intensity of select characters, particularly the floral, spicy or aromatic characters derived from the heart notes. Unfortunately, the consequence of using high levels of base notes is that they may impart particularly undesirable characters, such as for example, musky, woody, ambery, warm and sweet, which overpower and dominate the more desirable fragrance characters over time, particular over long periods of time. Thus, the unique challenge remains of selectively extending the more desirable characters attributable from the heart and/or top notes, particularly the heart notes, and even more particularly extending these desirable characters over long periods of time."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.6, "construct": {"method_text_verbatim": "Thus, it is an advantage of the present invention to provide new rules for objectively classifying fragrance materials according to their volatility using their their vapor pressures defined at suitable temperature, instead of their characters. The new rules operate irrespective of perfumers performing the classification. In particular, the new rules classify the fragrance materials into low, moderate or high volatile fragrance materials for formulating into fragrance mixtures, particularly ones having a diamond construction. It is a further advantage of the present invention to provide compositions having improved fidelity to the perceived fragrance profile over time. It is yet a further advantage to provide a composition, wherein the character attributable to moderate and high volatile fragrance materials, particularly the moderate volatile fragrance materials, remains significantly consistent from its initial impression to the end. It is yet a further advantage to provide compositio", "panel_size": null, "property_name": "longevity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["8 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "8 hours", "patent_id": "US20180180391A1", "provenance": {"citation": "US20180180391A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20180180391A1/en"}, "pub_date": "2018-01-23", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:13", "units": "hours", "verbatim_quote": "Thus, it is an advantage of the present invention to provide new rules for objectively classifying fragrance materials according to their volatility using their their vapor pressures defined at suitable temperature, instead of their characters. The new rules operate irrespective of perfumers performing the classification. In particular, the new rules classify the fragrance materials into low, moderate or high volatile fragrance materials for formulating into fragrance mixtures, particularly ones having a diamond construction. It is a further advantage of the present invention to provide compositions having improved fidelity to the perceived fragrance profile over time. It is yet a further advantage to provide a composition, wherein the character attributable to moderate and high volatile fragrance materials, particularly the moderate volatile fragrance materials, remains significantly consistent from its initial impression to the end. It is yet a further advantage to provide compositions having improved longevity of the perceived fragrance profile, preferably the characters attributable from the moderate or high volatile fragrance materials, particularly the moderate volatile fragrance material. It is yet a further advantage to provide compositions having stable quality of end product (e.g., fragrance profile, visual appearance) substantially comparable to the classical fragrance pyramid three-tiered structure, preferably even after three months storage at 40\u00b0 C. It is yet a further advantage to be able to create new to the world fragrance profiles wherein one, or several, well-recognized moderate volatile fragrance material characters, are maintained over time, preferably for long periods of time (e.g., greater than 4, 6, or even 8 hours)."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.85, "construct": {"method_text_verbatim": "The present invention provides a method for imparting, intensifying, or modifying an odour on human skin or human hair, comprising applying to human skin and/or human hair the composition of the present invention. It is preferred that the method is for imparting, intensifying or modifying the longevity of a floral character or aromatic/spicy character on human skin or human hair, wherein the perceived intensity of the floral character or aromatic/spicy character at 1 hr, 2 hrs, 3 hrs or 6 hrs after application is greater than a control composition that does not include the substantially non-odorous fragrance modulator as determined by the panel method as disclosed herein.", "panel_size": null, "property_name": "longevity", "scale": "hours_or_timepoint", "substrate": ["hair", "skin"], "time_points": ["1 hr", "2 hrs", "3 hrs", "6 hrs"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "1 hr; 2 hrs; 3 hrs; 6 hrs", "patent_id": "US20180180391A1", "provenance": {"citation": "US20180180391A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20180180391A1/en"}, "pub_date": "2018-01-23", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:113", "units": "hours", "verbatim_quote": "The present invention provides a method for imparting, intensifying, or modifying an odour on human skin or human hair, comprising applying to human skin and/or human hair the composition of the present invention. It is preferred that the method is for imparting, intensifying or modifying the longevity of a floral character or aromatic/spicy character on human skin or human hair, wherein the perceived intensity of the floral character or aromatic/spicy character at 1 hr, 2 hrs, 3 hrs or 6 hrs after application is greater than a control composition that does not include the substantially non-odorous fragrance modulator as determined by the panel method as disclosed herein."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.7, "construct": {"method_text_verbatim": "At the testing facility, 50 \u03bcL samples of the compositions and the controls are applied to glass slides and placed on a hot plate at 32\u00b0 C. to represent skin temperature for varying durations. It is important that glass slides of samples that are to be later compared are prepared at the same time. The panelists are asked to evaluate the perceived fragrance profile (intensity and/or character) of each glass slide sample at a given time point. Slides are presented coded so that their identity is not known by the panelists. Within a given time point panelists evaluate the slides in a random order and are able to revisit their assessment as they work through the slides at that time point. Their assessments are recorded. In the subsequent analysis, the data for strength and character comparisons are drawn from the independent assessments carried out at a given time point. Only when using the character difference scale below are any 2 products physically directly compared to each other. Pane", "panel_size": null, "property_name": "duration", "scale": "numeric_unknown", "substrate": ["skin"], "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "6-10", "patent_id": "US20180180391A1", "provenance": {"citation": "US20180180391A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20180180391A1/en"}, "pub_date": "2018-01-23", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:1925", "units": null, "verbatim_quote": "At the testing facility, 50 \u03bcL samples of the compositions and the controls are applied to glass slides and placed on a hot plate at 32\u00b0 C. to represent skin temperature for varying durations. It is important that glass slides of samples that are to be later compared are prepared at the same time. The panelists are asked to evaluate the perceived fragrance profile (intensity and/or character) of each glass slide sample at a given time point. Slides are presented coded so that their identity is not known by the panelists. Within a given time point panelists evaluate the slides in a random order and are able to revisit their assessment as they work through the slides at that time point. Their assessments are recorded. In the subsequent analysis, the data for strength and character comparisons are drawn from the independent assessments carried out at a given time point. Only when using the character difference scale below are any 2 products physically directly compared to each other. Panelists are selected from individuals who are either trained to evaluate fragrances according to the scales below or who have experience of fragrance evaluation in the industry. Typically, around 6-10 panellists are used to evaluate a given product and its control."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.55, "construct": {"method_text_verbatim": "The panelists are asked to give a score on a scale of 0 to 5 for perceived fragrance intensity according to the odour intensity scale set out in Table 4 herein below.", "panel_size": null, "property_name": "fragrance_intensity", "scale": "numeric_unknown", "substrate": null, "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "0 to 5", "patent_id": "US20180180391A1", "provenance": {"citation": "US20180180391A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20180180391A1/en"}, "pub_date": "2018-01-23", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:1927", "units": null, "verbatim_quote": "The panelists are asked to give a score on a scale of 0 to 5 for perceived fragrance intensity according to the odour intensity scale set out in Table 4 herein below."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": "example 10", "confidence": 0.9, "construct": {"method_text_verbatim": "1. The test and control compositions as described in the Example section are used for the evaluation. 2. Capillaries of about 2 cm to 3.5 cm, with one sealed end are cut from a Sigma Aldrich \u201cStuart\u2122 melting point tube\u201d product code Z673269, or equivalent. A suitable fixed volume chosen between 50 and 200 \u03bcL of the composition is pipetted into the well of a VWR Tissue Culture 96 F well plate, or equivalent. The sealed end of the glass capillary is dipped into the filled well and left for at least 15 secs to wet the surface of the glass. Care must be taken not to contact the glass capillary with the sides of the well by maintaining it straight and approximately in the center of the well. 3. The glass capillary is then removed from the well and inverted or transferred onto a stable surface or into a holder and allowed to evaporate at ambient conditions for a set period of time. A windshield may be used to reduce high air turbulence. 4. The glass capillary is then introduced into an empty", "panel_size": null, "property_name": "headspace_concentration_or_intensity", "scale": "hours_or_timepoint", "substrate": ["headspace"], "time_points": ["1 hr", "2 hrs", "3 hrs", "4 hrs", "5 hrs", "6 hrs"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "1 hr; 2 hrs; 3 hrs; 4 hrs; 5 hrs; 6 hrs; 50/30", "patent_id": "US20180180391A1", "provenance": {"citation": "US20180180391A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20180180391A1/en"}, "pub_date": "2018-01-23", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:0000", "units": "hours", "verbatim_quote": "1. The test and control compositions as described in the Example section are used for the evaluation. 2. Capillaries of about 2 cm to 3.5 cm, with one sealed end are cut from a Sigma Aldrich \u201cStuart\u2122 melting point tube\u201d product code Z673269, or equivalent. A suitable fixed volume chosen between 50 and 200 \u03bcL of the composition is pipetted into the well of a VWR Tissue Culture 96 F well plate, or equivalent. The sealed end of the glass capillary is dipped into the filled well and left for at least 15 secs to wet the surface of the glass. Care must be taken not to contact the glass capillary with the sides of the well by maintaining it straight and approximately in the center of the well. 3. The glass capillary is then removed from the well and inverted or transferred onto a stable surface or into a holder and allowed to evaporate at ambient conditions for a set period of time. A windshield may be used to reduce high air turbulence. 4. The glass capillary is then introduced into an empty 20 mL HS vial, which is immediately closed with a PTFE cap. The time at which this takes place is determined to be time T=initial (i.e., T=10 mins). 5. Multiple glass capillaries are prepared in the same way and left to evaporate at ambient temperature for pre-determined periods of time, such as for example 10, 15, 30 mins, 1 hr, 2 hrs, 3 hrs, 4 hrs, 5 hrs, and up to 6 hrs, before being introduced to the headspace vial and sealed. 6. The HS vial is then analysed on an Agilent GC system 6890 equipped with a Gerstel MPS 2 autosampler, or equivalent, capable of performing SPME injections. A SPME fiber assembly DVB/CAR/PDMS (50/30 \u03bcm, 1 cm length) is required. A GC column such as a DB-5MS, ZB-5MSi models, or equivalent phase, with a length of 30 m, an inner diameter of 0.25 mm and a film thickness of 1 \u03bcm is used. 7. The SPME HS parameters are set to the values indicated as follows:"}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": "example 10", "confidence": 0.9, "construct": {"method_text_verbatim": "5. Multiple glass capillaries are prepared in the same way and left to evaporate at ambient temperature for pre-determined periods of time, such as for example 10, 15, 30 mins, 1 hr, 2 hrs, 3 hrs, 4 hrs, 5 hrs, and up to 6 hrs, before being introduced to the headspace vial and sealed.", "panel_size": null, "property_name": "headspace_concentration_or_intensity", "scale": "hours_or_timepoint", "substrate": ["headspace"], "time_points": ["1 hr", "2 hrs", "3 hrs", "4 hrs", "5 hrs", "6 hrs"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "1 hr; 2 hrs; 3 hrs; 4 hrs; 5 hrs; 6 hrs", "patent_id": "US20180180391A1", "provenance": {"citation": "US20180180391A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20180180391A1/en"}, "pub_date": "2018-01-23", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:0241", "units": "hours", "verbatim_quote": "5. Multiple glass capillaries are prepared in the same way and left to evaporate at ambient temperature for pre-determined periods of time, such as for example 10, 15, 30 mins, 1 hr, 2 hrs, 3 hrs, 4 hrs, 5 hrs, and up to 6 hrs, before being introduced to the headspace vial and sealed."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.7, "construct": {"method_text_verbatim": "Compositions disclosed in Tables 18(a)-18(d), 20, 21, and 22(a)-22(d) are applied to glass slides in accordance with the protocol described in the Method Section and a panel of 6-10 experienced panelists evaluate the perceived fragrance profile at initial time 0, then at various time points, typically 1 hour, 2 hours, 3 hours, 4 hours and 6 hours post application. Panelists are asked to score the compositions for the longevity and/or fidelity of the fragrance profile on a scale of 0 to 5, wherein 0 represents a no fragrance is detected and 5 represents a very strong fragrance intensity is detected. The results of the panelists are then averaged and discussed below.", "panel_size": null, "property_name": "fragrance_intensity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["1 hour", "2 hours", "3 hours", "4 hours", "6 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "6-10; 1 hour; 2 hours; 3 hours; 4 hours; 6 hours; 0 to 5", "patent_id": "US20180180391A1", "provenance": {"citation": "US20180180391A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20180180391A1/en"}, "pub_date": "2018-01-23", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:2941", "units": "hours", "verbatim_quote": "Compositions disclosed in Tables 18(a)-18(d), 20, 21, and 22(a)-22(d) are applied to glass slides in accordance with the protocol described in the Method Section and a panel of 6-10 experienced panelists evaluate the perceived fragrance profile at initial time 0, then at various time points, typically 1 hour, 2 hours, 3 hours, 4 hours and 6 hours post application. Panelists are asked to score the compositions for the longevity and/or fidelity of the fragrance profile on a scale of 0 to 5, wherein 0 represents a no fragrance is detected and 5 represents a very strong fragrance intensity is detected. The results of the panelists are then averaged and discussed below."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.7, "construct": {"method_text_verbatim": "FIG. 2 shows the fragrance intensity profile of Composition A9 (as disclosed in Table 22(c)) as evaluated by 10 panelists, which comprises the substantially non-odorous fragrance modulator Bis-methoxy PEG-13 PEG-438/PPG-110 SMDI Copolymer (i.e., Expert Gel\u00ae 56) and the single fragrance material Indocolore. Addition of the substantially non-odorous fragrance modulator (Expert Gel\u00ae 56) maintains the intensity of the fragrance material for up to at least 6 hours whilst the control, Composition B9, in the absence of the substantially non-odorous fragrance modulator, drops in fragrance intensity profile much more over this time. The substantially non-odorous fragrance modulator acts to maintain the continued initial evaporation over time of the fragrance material. Statistical analysis using the Tukey correction for multiple comparisons confirms the statistically significant difference at 1, 3 and 6 hours (p<0.0001) at 95% significance level (i.e., p<0.05) at all these time points.", "panel_size": 10, "property_name": "fragrance_intensity", "scale": "percent", "substrate": null, "time_points": ["6 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "6 hours", "patent_id": "US20180180391A1", "provenance": {"citation": "US20180180391A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20180180391A1/en"}, "pub_date": "2018-01-23", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:2943", "units": "hours", "verbatim_quote": "FIG. 2 shows the fragrance intensity profile of Composition A9 (as disclosed in Table 22(c)) as evaluated by 10 panelists, which comprises the substantially non-odorous fragrance modulator Bis-methoxy PEG-13 PEG-438/PPG-110 SMDI Copolymer (i.e., Expert Gel\u00ae 56) and the single fragrance material Indocolore. Addition of the substantially non-odorous fragrance modulator (Expert Gel\u00ae 56) maintains the intensity of the fragrance material for up to at least 6 hours whilst the control, Composition B9, in the absence of the substantially non-odorous fragrance modulator, drops in fragrance intensity profile much more over this time. The substantially non-odorous fragrance modulator acts to maintain the continued initial evaporation over time of the fragrance material. Statistical analysis using the Tukey correction for multiple comparisons confirms the statistically significant difference at 1, 3 and 6 hours (p<0.0001) at 95% significance level (i.e., p<0.05) at all these time points."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.7, "construct": {"method_text_verbatim": "FIG. 3 shows the fragrance intensity profile of Composition C9 (as disclosed in Table 22(c)) as evaluated by 9 panelists, which comprises the substantially non-odorous fragrance modulator propyl {4-[2-(diethylamino)-2-oxoethoxy]-3-methoxyphenyl}acetate (i.e., Kolliphor\u00ae EL) and the single fragrance material Dimethyl Benzyl Carbinol. Addition of the substantially non-odorous fragrance modulator (Kolliphor\u00ae EL) maintains the intensity of the fragrance material for up to at least 6 hours whilst the control, Composition D9, in the absence of the substantially non-odorous fragrance modulator, drops in fragrance intensity profile much more over this time. The substantially non-odorous fragrance modulator acts to maintain the reduced rate of evaporation over time of the fragrance material. Statistical analysis using the Tukey correction for multiple comparisons confirms the statistically significant difference at 1 hour (p<0.0001), 3 hours (p=0.0265) and 6 hours (p=0.0388) at 95% significance", "panel_size": 9, "property_name": "fragrance_intensity", "scale": "percent", "substrate": null, "time_points": ["6 hours", "1 hour", "3 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "6 hours; 1 hour; 3 hours", "patent_id": "US20180180391A1", "provenance": {"citation": "US20180180391A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20180180391A1/en"}, "pub_date": "2018-01-23", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:2944", "units": "hours", "verbatim_quote": "FIG. 3 shows the fragrance intensity profile of Composition C9 (as disclosed in Table 22(c)) as evaluated by 9 panelists, which comprises the substantially non-odorous fragrance modulator propyl {4-[2-(diethylamino)-2-oxoethoxy]-3-methoxyphenyl}acetate (i.e., Kolliphor\u00ae EL) and the single fragrance material Dimethyl Benzyl Carbinol. Addition of the substantially non-odorous fragrance modulator (Kolliphor\u00ae EL) maintains the intensity of the fragrance material for up to at least 6 hours whilst the control, Composition D9, in the absence of the substantially non-odorous fragrance modulator, drops in fragrance intensity profile much more over this time. The substantially non-odorous fragrance modulator acts to maintain the reduced rate of evaporation over time of the fragrance material. Statistical analysis using the Tukey correction for multiple comparisons confirms the statistically significant difference at 1 hour (p<0.0001), 3 hours (p=0.0265) and 6 hours (p=0.0388) at 95% significance level (i.e., p<0.05) at all these time points."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.7, "construct": {"method_text_verbatim": "FIG. 4 shows the fragrance intensity profile of Composition E9 (as disclosed in Table 22(c)) as evaluated by 9 panelists, which comprises the substantially non-odorous fragrance modulator propyl {4-[2-(diethylamino)-2-oxoethoxy]-3-methoxyphenyl}acetate (i.e., Kolliphor\u00ae EL) and the single fragrance material Eugenol. Addition of the substantially non-odorous fragrance modulator (Kolliphor\u00ae EL) maintains the intensity of the fragrance material for up to at least 6 hours whilst the control, Composition F9, in the absence of the substantially non-odorous fragrance modulator, drops in fragrance intensity profile much more over this time. The substantially non-odorous fragrance modulator acts to suppress the initial display of Eugenol and then maintains that continued initial evaporation over time. Statistical analysis using the Tukey correction for multiple comparisons confirms the statistically significant difference at 0 hours (p=0.0025), 1 hour (p<0.0001), 3 hours (p<0.0001) and 6 hours ", "panel_size": 9, "property_name": "fragrance_intensity", "scale": "percent", "substrate": null, "time_points": ["6 hours", "0 hours", "1 hour", "3 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "6 hours; 0 hours; 1 hour; 3 hours", "patent_id": "US20180180391A1", "provenance": {"citation": "US20180180391A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20180180391A1/en"}, "pub_date": "2018-01-23", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:2945", "units": "hours", "verbatim_quote": "FIG. 4 shows the fragrance intensity profile of Composition E9 (as disclosed in Table 22(c)) as evaluated by 9 panelists, which comprises the substantially non-odorous fragrance modulator propyl {4-[2-(diethylamino)-2-oxoethoxy]-3-methoxyphenyl}acetate (i.e., Kolliphor\u00ae EL) and the single fragrance material Eugenol. Addition of the substantially non-odorous fragrance modulator (Kolliphor\u00ae EL) maintains the intensity of the fragrance material for up to at least 6 hours whilst the control, Composition F9, in the absence of the substantially non-odorous fragrance modulator, drops in fragrance intensity profile much more over this time. The substantially non-odorous fragrance modulator acts to suppress the initial display of Eugenol and then maintains that continued initial evaporation over time. Statistical analysis using the Tukey correction for multiple comparisons confirms the statistically significant difference at 0 hours (p=0.0025), 1 hour (p<0.0001), 3 hours (p<0.0001) and 6 hours (p<0.0001) at 95% significance level (i.e., p<0.05) at all time points."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.7, "construct": {"method_text_verbatim": "FIG. 5 shows the fragrance intensity profile of Composition G9 (as disclosed in Table 22(c)) as evaluated by 9 panelists, which comprises the substantially non-odorous fragrance modulator propyl {4-[2-(diethylamino)-2-oxoethoxy]-3-methoxyphenyl}acetate (i.e., Kolliphor\u00ae EL) and the single fragrance material Phenethyl alcohol (PEA). Addition of the substantially non-odorous fragrance modulator (Kolliphor\u00ae EL) maintains the intensity of the fragrance material from 1 hour to 3 hours whilst the control, Composition H9, in the absence of the substantially non-odorous fragrance modulator, drops in fragrance intensity profile over this time. The substantially non-odorous fragrance modulator acts to maintain the reduced rate of evaporation over time of the fragrance material. Statistical analysis using the Tukey correction for multiple comparisons confirms the statistically significant difference at 1 hour (p<0.0001) at 95% significance level (i.e., p<0.05) and at 3 hours (p=0.0876) at 90% sig", "panel_size": 9, "property_name": "fragrance_intensity", "scale": "percent", "substrate": null, "time_points": ["1 hour", "3 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "1 hour; 3 hours", "patent_id": "US20180180391A1", "provenance": {"citation": "US20180180391A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20180180391A1/en"}, "pub_date": "2018-01-23", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:2946", "units": "hours", "verbatim_quote": "FIG. 5 shows the fragrance intensity profile of Composition G9 (as disclosed in Table 22(c)) as evaluated by 9 panelists, which comprises the substantially non-odorous fragrance modulator propyl {4-[2-(diethylamino)-2-oxoethoxy]-3-methoxyphenyl}acetate (i.e., Kolliphor\u00ae EL) and the single fragrance material Phenethyl alcohol (PEA). Addition of the substantially non-odorous fragrance modulator (Kolliphor\u00ae EL) maintains the intensity of the fragrance material from 1 hour to 3 hours whilst the control, Composition H9, in the absence of the substantially non-odorous fragrance modulator, drops in fragrance intensity profile over this time. The substantially non-odorous fragrance modulator acts to maintain the reduced rate of evaporation over time of the fragrance material. Statistical analysis using the Tukey correction for multiple comparisons confirms the statistically significant difference at 1 hour (p<0.0001) at 95% significance level (i.e., p<0.05) and at 3 hours (p=0.0876) at 90% significance level (i.e., p<0.1)."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.7, "construct": {"method_text_verbatim": "Panelists are asked to score the compositions for the intensity of the fragrance on a scale of 0 to 5, wherein 0 represents a no fragrance intensity is detected and 5 represents a very strong fragrance intensity is detected. The results of the panel test are then averaged. The results show the effect of the substantially non-odorous fragrance modulator and diamond constructed fragrance materials for any one of the inventive Compositions A1, A2, A3, A4, A5, D1, D2, D4, G1, G2, G4, J1, J2, J4, M1, and M2 on fragrance profile longevity versus control Compositions C1, C2, C3, C4, C5, F1, F2, F4, I1, I2, I4, L1, L2, L4, O1, and O2 in the absence of the substantially non-odorous modulator. Alternatively, the results show the effect of the substantially non-odorous fragrance modulator and diamond constructed fragrance materials for any one of the inventive Compositions A1, A2, A3, A4, A5, D1, D2, D4, G1, G2, G4, J1, J2, J4, M1, and M2 on fragrance profile longevity versus traditional Composit", "panel_size": null, "property_name": "fragrance_intensity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["6 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "0 to 5; 6 hours", "patent_id": "US20180180391A1", "provenance": {"citation": "US20180180391A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20180180391A1/en"}, "pub_date": "2018-01-23", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:2948", "units": "hours", "verbatim_quote": "Panelists are asked to score the compositions for the intensity of the fragrance on a scale of 0 to 5, wherein 0 represents a no fragrance intensity is detected and 5 represents a very strong fragrance intensity is detected. The results of the panel test are then averaged. The results show the effect of the substantially non-odorous fragrance modulator and diamond constructed fragrance materials for any one of the inventive Compositions A1, A2, A3, A4, A5, D1, D2, D4, G1, G2, G4, J1, J2, J4, M1, and M2 on fragrance profile longevity versus control Compositions C1, C2, C3, C4, C5, F1, F2, F4, I1, I2, I4, L1, L2, L4, O1, and O2 in the absence of the substantially non-odorous modulator. Alternatively, the results show the effect of the substantially non-odorous fragrance modulator and diamond constructed fragrance materials for any one of the inventive Compositions A1, A2, A3, A4, A5, D1, D2, D4, G1, G2, G4, J1, J2, J4, M1, and M2 on fragrance profile longevity versus traditional Compositions B1, B2, B3, B4, B5, E1, E2, E4, H1, H2, H4, K1, K2, K4, N1, and N2 in the presence of the substantially non-odorous fragrance modulator. Fragrance profile longevity, particularly intensity of the characters attributable to the volatile fragrance materials are maintained for up to at least 6 hours in the presence of the substantially non-odorous fragrance modulator whilst it drops in the absence of the substantially non-odorous fragrance modulator."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": "Example 4b", "confidence": 0.75, "construct": {"method_text_verbatim": "FIG. 6 provides the fragrance intensity profile of Composition A4 (as disclosed in Table 18(d)), which comprises the substantially non-odorous fragrance modulator PPG-20 Methyl Glucose Ether (i.e., Glucam\u2122 P-20) and the Diamond Floral Magnifica Fragrance Example 4b. Addition of the substantially non-odorous fragrance modulator Glucam\u2122 P-20 maintains the intensity of the fragrance material for up to 6 hours. As compared to the control Composition C4, in the absence of the substantially non-odorous fragrance modulator Glucam\u2122 P-20, and comprising the Traditional Floral Magnifica Fragrance Example 4a drops in fragrance intensity over the 6 hours.", "panel_size": null, "property_name": "fragrance_intensity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["6 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "6 hours", "patent_id": "US20180180391A1", "provenance": {"citation": "US20180180391A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20180180391A1/en"}, "pub_date": "2018-01-23", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:2949", "units": "hours", "verbatim_quote": "FIG. 6 provides the fragrance intensity profile of Composition A4 (as disclosed in Table 18(d)), which comprises the substantially non-odorous fragrance modulator PPG-20 Methyl Glucose Ether (i.e., Glucam\u2122 P-20) and the Diamond Floral Magnifica Fragrance Example 4b. Addition of the substantially non-odorous fragrance modulator Glucam\u2122 P-20 maintains the intensity of the fragrance material for up to 6 hours. As compared to the control Composition C4, in the absence of the substantially non-odorous fragrance modulator Glucam\u2122 P-20, and comprising the Traditional Floral Magnifica Fragrance Example 4a drops in fragrance intensity over the 6 hours."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": "Example 5b", "confidence": 0.75, "construct": {"method_text_verbatim": "FIG. 7 provides the fragrance intensity profile of Composition A4 (as disclosed in Table 18(d)), which comprises the substantially non-odorous fragrance modulator PPG-20 Methyl Glucose Ether (i.e., Glucam\u2122 P-20) and the Diamond Muguesia Magnifica Fragrance Example 5b. Addition of the substantially non-odorous fragrance modulator Glucam\u2122 P-20 maintains the intensity of the fragrance material for up to 6 hours. As compared to the control Composition C4, in the absence of the substantially non-odorous fragrance modulator Glucam\u2122 P-20, and comprising the Traditional Muguesia Magnifica Fragrance Example 5a drops in fragrance intensity over the 6 hours.", "panel_size": null, "property_name": "fragrance_intensity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["6 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "6 hours", "patent_id": "US20180180391A1", "provenance": {"citation": "US20180180391A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20180180391A1/en"}, "pub_date": "2018-01-23", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:2950", "units": "hours", "verbatim_quote": "FIG. 7 provides the fragrance intensity profile of Composition A4 (as disclosed in Table 18(d)), which comprises the substantially non-odorous fragrance modulator PPG-20 Methyl Glucose Ether (i.e., Glucam\u2122 P-20) and the Diamond Muguesia Magnifica Fragrance Example 5b. Addition of the substantially non-odorous fragrance modulator Glucam\u2122 P-20 maintains the intensity of the fragrance material for up to 6 hours. As compared to the control Composition C4, in the absence of the substantially non-odorous fragrance modulator Glucam\u2122 P-20, and comprising the Traditional Muguesia Magnifica Fragrance Example 5a drops in fragrance intensity over the 6 hours."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": "Example 4b", "confidence": 0.75, "construct": {"method_text_verbatim": "FIG. 8 provides the fragrance intensity profile of Composition A2 (as disclosed in Table 18(b)), which comprises 15 wt % substantially non-odorous fragrance modulator Diisobutyl Adipate and 7 wt % Diamond Floral Magnifica Fragrance Example 4b. Addition of the substantially non-odorous fragrance modulator Diisobutyl Adipate maintains the intensity of the fragrance material for up to 6 hours. As compared to the control Composition C2, in the absence of the substantially non-odorous fragrance modulator Diisobutyl Adipate, and comprising 7 wt % Traditional Floral Magnifica Fragrance Example 4a drops in fragrance intensity over the 6 hours.", "panel_size": null, "property_name": "fragrance_intensity", "scale": "percent", "substrate": null, "time_points": ["6 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "6 hours", "patent_id": "US20180180391A1", "provenance": {"citation": "US20180180391A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20180180391A1/en"}, "pub_date": "2018-01-23", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:2951", "units": "hours", "verbatim_quote": "FIG. 8 provides the fragrance intensity profile of Composition A2 (as disclosed in Table 18(b)), which comprises 15 wt % substantially non-odorous fragrance modulator Diisobutyl Adipate and 7 wt % Diamond Floral Magnifica Fragrance Example 4b. Addition of the substantially non-odorous fragrance modulator Diisobutyl Adipate maintains the intensity of the fragrance material for up to 6 hours. As compared to the control Composition C2, in the absence of the substantially non-odorous fragrance modulator Diisobutyl Adipate, and comprising 7 wt % Traditional Floral Magnifica Fragrance Example 4a drops in fragrance intensity over the 6 hours."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": "Example 5b", "confidence": 0.75, "construct": {"method_text_verbatim": "FIG. 9 provides the fragrance intensity profile of Composition A2 (as disclosed in Table 18(b)), which comprises 15 wt % substantially non-odorous fragrance modulator Diisobutyl Adipate and 7 wt % Diamond Muguesia Magnifica Fragrance Example 5b. Addition of the substantially non-odorous fragrance modulator Diisobutyl Adipate maintains the intensity of the fragrance material for up to 6 hours. As compared to the control Composition C2, in the absence of the substantially non-odorous fragrance modulator Diisobutyl Adipate, and comprising 7 wt % Traditional Muguesia Magnifica Fragrance Example 5a drops in fragrance intensity over the 6 hours.", "panel_size": null, "property_name": "fragrance_intensity", "scale": "percent", "substrate": null, "time_points": ["6 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "6 hours", "patent_id": "US20180180391A1", "provenance": {"citation": "US20180180391A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20180180391A1/en"}, "pub_date": "2018-01-23", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:2952", "units": "hours", "verbatim_quote": "FIG. 9 provides the fragrance intensity profile of Composition A2 (as disclosed in Table 18(b)), which comprises 15 wt % substantially non-odorous fragrance modulator Diisobutyl Adipate and 7 wt % Diamond Muguesia Magnifica Fragrance Example 5b. Addition of the substantially non-odorous fragrance modulator Diisobutyl Adipate maintains the intensity of the fragrance material for up to 6 hours. As compared to the control Composition C2, in the absence of the substantially non-odorous fragrance modulator Diisobutyl Adipate, and comprising 7 wt % Traditional Muguesia Magnifica Fragrance Example 5a drops in fragrance intensity over the 6 hours."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.6, "construct": {"method_text_verbatim": "Without wishing to be bound by theory, it is believed that the substantially non-odorous fragrance modulator acts to maintain the continued evaporation over time of the fragrance materials, particular the volatile fragrance materials. The effects of the improved fragrance profile longevity of the present invention are noticeable at, any one of, 1, 3 and 6 hours post application.", "panel_size": null, "property_name": "longevity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["6 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "6 hours", "patent_id": "US20180180391A1", "provenance": {"citation": "US20180180391A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20180180391A1/en"}, "pub_date": "2018-01-23", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:2954", "units": "hours", "verbatim_quote": "Without wishing to be bound by theory, it is believed that the substantially non-odorous fragrance modulator acts to maintain the continued evaporation over time of the fragrance materials, particular the volatile fragrance materials. The effects of the improved fragrance profile longevity of the present invention are noticeable at, any one of, 1, 3 and 6 hours post application."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.6, "construct": {"method_text_verbatim": "The test demonstrates the character retention over time of a fragrance composition. The results show the effect of the substantially non-odorous fragrance modulator and fragrance materials in a diamond construction for any one of the inventive Compositions A1, A2, A3, A4, A5, D1, D2, D4, G1, G2, G4, J1, J2, J4, M1, and M2 on fragrance profile versus control Compositions C1, C2, C3, C4, C5, F1, F2, F4, I1, I2, I4, L1, L2, L4, O1, and O2 in the absence of the substantially non-odorous fragrance modulator. Alternatively, results show the effect of the substantially non-odorous fragrance modulator and fragrance materials in a diamond construction for any one of the inventive Compositions A1, A2, A3, A4, A5, D1, D2, D4, G1, G2, G4, J1, J2, J4, M1, and M2 on fragrance profile longevity versus traditional Compositions B1, B2, B3, B4, B5, E1, E2, E4, H1, H2, H4, K1, K2, K4, N1, and N2 in the presence of the substantially non-odorous fragrance modulator. Fragrance profile fidelity, particularly", "panel_size": null, "property_name": "longevity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["1 hour"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "1 hour", "patent_id": "US20180180391A1", "provenance": {"citation": "US20180180391A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20180180391A1/en"}, "pub_date": "2018-01-23", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:2980", "units": "hours", "verbatim_quote": "The test demonstrates the character retention over time of a fragrance composition. The results show the effect of the substantially non-odorous fragrance modulator and fragrance materials in a diamond construction for any one of the inventive Compositions A1, A2, A3, A4, A5, D1, D2, D4, G1, G2, G4, J1, J2, J4, M1, and M2 on fragrance profile versus control Compositions C1, C2, C3, C4, C5, F1, F2, F4, I1, I2, I4, L1, L2, L4, O1, and O2 in the absence of the substantially non-odorous fragrance modulator. Alternatively, results show the effect of the substantially non-odorous fragrance modulator and fragrance materials in a diamond construction for any one of the inventive Compositions A1, A2, A3, A4, A5, D1, D2, D4, G1, G2, G4, J1, J2, J4, M1, and M2 on fragrance profile longevity versus traditional Compositions B1, B2, B3, B4, B5, E1, E2, E4, H1, H2, H4, K1, K2, K4, N1, and N2 in the presence of the substantially non-odorous fragrance modulator. Fragrance profile fidelity, particularly of floral characters attributable to the volatile fragrance materials are maintained for up to at least 1 hour in the presence of the substantially non-odorous fragrance modulator whilst it drops in the absence of the substantially non-odorous fragrance modulator."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.6, "construct": {"method_text_verbatim": "There are at least one of several drawbacks to the above described classical formulation approach. Firstly, classification of fragrance materials by their characters is subjective and therefore results in inconsistency in the fragrance profile under classical fragrance pyramid construction rules. Secondly, the perceived intensity of the fragrance profile of the conventional perfume compositions, particularly those characters attributable to the more volatile fragrance materials, decreases rapidly over time due to their quick evaporation. Accordingly, conventional perfume compositions will typically change their overall fragrance profile over time. This is a problem because it is desirable to maintain \u201cfragrance profile fidelity\u201d over time. In other words, it is desirable to maintain the same or substantively similar fragrance profile for a commercial fragrance over time, particularly over long periods of time (at least 4 hrs, 6 hrs, or even 8 hours after application). Thirdly, with the", "panel_size": null, "property_name": "fragrance_intensity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["4 hrs", "6 hrs", "8 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "4 hrs; 6 hrs; 8 hours", "patent_id": "US20160362630A1", "provenance": {"citation": "US20160362630A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20160362630A1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:5", "units": "hours", "verbatim_quote": "There are at least one of several drawbacks to the above described classical formulation approach. Firstly, classification of fragrance materials by their characters is subjective and therefore results in inconsistency in the fragrance profile under classical fragrance pyramid construction rules. Secondly, the perceived intensity of the fragrance profile of the conventional perfume compositions, particularly those characters attributable to the more volatile fragrance materials, decreases rapidly over time due to their quick evaporation. Accordingly, conventional perfume compositions will typically change their overall fragrance profile over time. This is a problem because it is desirable to maintain \u201cfragrance profile fidelity\u201d over time. In other words, it is desirable to maintain the same or substantively similar fragrance profile for a commercial fragrance over time, particularly over long periods of time (at least 4 hrs, 6 hrs, or even 8 hours after application). Thirdly, with the classical fragrance pyramid construction, the possible types of fragrance profiles have been somewhat limited. The consequence of using base notes at high levels is that many fragrance dry-downs appear repetitive, boring, non-memorable and un-interesting to consumers. However, if base notes are reduced or excluded then the fragrance intensity weakens over time and does not last for a sufficient duration. Lastly, it is generally accepted that some consumers desire prolonged intensity of select characters, particularly the floral, spicy or aromatic characters derived from the heart notes. Unfortunately, the consequence of using high levels of base notes is that they may impart particularly undesirable characters, such as for example, musky, woody, ambery, warm and sweet, which overpower and dominate the more desirable fragrance characters over time, particular over long periods of time. Thus, the unique challenge remains of selectively extending the more desirable characters attributable from the heart and/or top notes, particularly the heart notes, and even more particularly extending these desirable characters over long periods of time."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.6, "construct": {"method_text_verbatim": "Thus, it is an advantage of the present invention to provide new rules for objectively classifying fragrance materials according to their volatility using their their vapor pressures defined at suitable temperature, instead of their characters. The new rules operate irrespective of perfumers performing the classification. In particular, the new rules classify the fragrance materials into low, moderate or high volatile fragrance materials for formulating into fragrance mixtures, particularly ones having a diamond construction. It is a further advantage of the present invention to provide compositions having improved fidelity to the perceived fragrance profile over time. It is yet a further advantage to provide a composition, wherein the character attributable to moderate and high volatile fragrance materials, particularly the moderate volatile fragrance materials, remains significantly consistent from its initial impression to the end. It is yet a further advantage to provide compositio", "panel_size": null, "property_name": "longevity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["8 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "8 hours", "patent_id": "US20160362630A1", "provenance": {"citation": "US20160362630A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20160362630A1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:13", "units": "hours", "verbatim_quote": "Thus, it is an advantage of the present invention to provide new rules for objectively classifying fragrance materials according to their volatility using their their vapor pressures defined at suitable temperature, instead of their characters. The new rules operate irrespective of perfumers performing the classification. In particular, the new rules classify the fragrance materials into low, moderate or high volatile fragrance materials for formulating into fragrance mixtures, particularly ones having a diamond construction. It is a further advantage of the present invention to provide compositions having improved fidelity to the perceived fragrance profile over time. It is yet a further advantage to provide a composition, wherein the character attributable to moderate and high volatile fragrance materials, particularly the moderate volatile fragrance materials, remains significantly consistent from its initial impression to the end. It is yet a further advantage to provide compositions having improved longevity of the perceived fragrance profile, preferably the characters attributable from the moderate or high volatile fragrance materials, particularly the moderate volatile fragrance material. It is yet a further advantage to provide compositions having stable quality of end product (e.g., fragrance profile, visual appearance) substantially comparable to the classical fragrance pyramid three-tiered structure, preferably even after three months storage at 40\u00b0 C. It is yet a further advantage to be able to create new to the world fragrance profiles wherein one, or several, well-recognized moderate volatile fragrance material characters, are maintained over time, preferably for long periods of time (e.g., greater than 4, 6, or even 8 hours)."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.85, "construct": {"method_text_verbatim": "The present invention provides a method for imparting, intensifying, or modifying an odour on human skin or human hair, comprising applying to human skin and/or human hair the composition of the present invention. It is preferred that the method is for imparting, intensifying or modifying the longevity of a floral character or aromatic/spicy character on human skin or human hair, wherein the perceived intensity of the floral character or aromatic/spicy character at 1 hr, 2 hrs, 3 hrs or 6 hrs after application is greater than a control composition that does not include the substantially non-odorous fragrance modulator as determined by the panel method as disclosed herein.", "panel_size": null, "property_name": "longevity", "scale": "hours_or_timepoint", "substrate": ["hair", "skin"], "time_points": ["1 hr", "2 hrs", "3 hrs", "6 hrs"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "1 hr; 2 hrs; 3 hrs; 6 hrs", "patent_id": "US20160362630A1", "provenance": {"citation": "US20160362630A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20160362630A1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:113", "units": "hours", "verbatim_quote": "The present invention provides a method for imparting, intensifying, or modifying an odour on human skin or human hair, comprising applying to human skin and/or human hair the composition of the present invention. It is preferred that the method is for imparting, intensifying or modifying the longevity of a floral character or aromatic/spicy character on human skin or human hair, wherein the perceived intensity of the floral character or aromatic/spicy character at 1 hr, 2 hrs, 3 hrs or 6 hrs after application is greater than a control composition that does not include the substantially non-odorous fragrance modulator as determined by the panel method as disclosed herein."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.7, "construct": {"method_text_verbatim": "At the testing facility, 50 \u03bcL samples of the compositions and the controls are applied to glass slides and placed on a hot plate at 32\u00b0 C. to represent skin temperature for varying durations. It is important that glass slides of samples that are to be later compared are prepared at the same time. The panelists are asked to evaluate the perceived fragrance profile (intensity and/or character) of each glass slide sample at a given time point. Slides are presented coded so that their identity is not known by the panelists. Within a given time point panelists evaluate the slides in a random order and are able to revisit their assessment as they work through the slides at that time point. Their assessments are recorded. In the subsequent analysis, the data for strength and character comparisons are drawn from the independent assessments carried out at a given time point. Only when using the character difference scale below are any 2 products physically directly compared to each other. Pane", "panel_size": null, "property_name": "duration", "scale": "numeric_unknown", "substrate": ["skin"], "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "6-10", "patent_id": "US20160362630A1", "provenance": {"citation": "US20160362630A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20160362630A1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:2203", "units": null, "verbatim_quote": "At the testing facility, 50 \u03bcL samples of the compositions and the controls are applied to glass slides and placed on a hot plate at 32\u00b0 C. to represent skin temperature for varying durations. It is important that glass slides of samples that are to be later compared are prepared at the same time. The panelists are asked to evaluate the perceived fragrance profile (intensity and/or character) of each glass slide sample at a given time point. Slides are presented coded so that their identity is not known by the panelists. Within a given time point panelists evaluate the slides in a random order and are able to revisit their assessment as they work through the slides at that time point. Their assessments are recorded. In the subsequent analysis, the data for strength and character comparisons are drawn from the independent assessments carried out at a given time point. Only when using the character difference scale below are any 2 products physically directly compared to each other. Panelists are selected from individuals who are either trained to evaluate fragrances according to the scales below or who have experience of fragrance evaluation in the industry. Typically, around 6-10 panellists are used to evaluate a given product and its control."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.55, "construct": {"method_text_verbatim": "The panelists are asked to give a score on a scale of 0 to 5 for perceived fragrance intensity according to the odour intensity scale set out in Table 4 herein below.", "panel_size": null, "property_name": "fragrance_intensity", "scale": "numeric_unknown", "substrate": null, "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "0 to 5", "patent_id": "US20160362630A1", "provenance": {"citation": "US20160362630A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20160362630A1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:2205", "units": null, "verbatim_quote": "The panelists are asked to give a score on a scale of 0 to 5 for perceived fragrance intensity according to the odour intensity scale set out in Table 4 herein below."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": "example 10", "confidence": 0.9, "construct": {"method_text_verbatim": "1. The test and control compositions as described in the Example section are used for the evaluation. 2. Capillaries of about 2 cm to 3.5 cm, with one sealed end are cut from a Sigma Aldrich \u201cStuart\u2122 melting point tube\u201d product code Z673269, or equivalent. A suitable fixed volume chosen between 50 and 200 \u03bcL of the composition is pipetted into the well of a VWR Tissue Culture 96 F well plate, or equivalent. The sealed end of the glass capillary is dipped into the filled well and left for at least 15 secs to wet the surface of the glass. Care must be taken not to contact the glass capillary with the sides of the well by maintaining it straight and approximately in the center of the well. 3. The glass capillary is then removed from the well and inverted or transferred onto a stable surface or into a holder and allowed to evaporate at ambient conditions for a set period of time. A windshield may be used to reduce high air turbulence. 4. The glass capillary is then introduced into an empty", "panel_size": null, "property_name": "headspace_concentration_or_intensity", "scale": "hours_or_timepoint", "substrate": ["headspace"], "time_points": ["1 hr", "2 hrs", "3 hrs", "4 hrs", "5 hrs", "6 hrs"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "1 hr; 2 hrs; 3 hrs; 4 hrs; 5 hrs; 6 hrs; 50/30", "patent_id": "US20160362630A1", "provenance": {"citation": "US20160362630A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20160362630A1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:0000", "units": "hours", "verbatim_quote": "1. The test and control compositions as described in the Example section are used for the evaluation. 2. Capillaries of about 2 cm to 3.5 cm, with one sealed end are cut from a Sigma Aldrich \u201cStuart\u2122 melting point tube\u201d product code Z673269, or equivalent. A suitable fixed volume chosen between 50 and 200 \u03bcL of the composition is pipetted into the well of a VWR Tissue Culture 96 F well plate, or equivalent. The sealed end of the glass capillary is dipped into the filled well and left for at least 15 secs to wet the surface of the glass. Care must be taken not to contact the glass capillary with the sides of the well by maintaining it straight and approximately in the center of the well. 3. The glass capillary is then removed from the well and inverted or transferred onto a stable surface or into a holder and allowed to evaporate at ambient conditions for a set period of time. A windshield may be used to reduce high air turbulence. 4. The glass capillary is then introduced into an empty 20 mL HS vial, which is immediately closed with a PTFE cap. The time at which this takes place is determined to be time T=initial (i.e., T=10 mins) 5. Multiple glass capillaries are prepared in the same way and left to evaporate at ambient temperature for pre-determined periods of time, such as for example 10, 15, 30 mins, 1 hr, 2 hrs, 3 hrs, 4 hrs, 5 hrs, and up to 6 hrs, before being introduced to the headspace vial and sealed. 6. The HS vial is then analysed on an Agilent GC system 6890 equipped with a Gerstel MPS 2 autosampler, or equivalent, capable of performing SPME injections. A SPME fiber assembly DVB/CAR/PDMS (50/30 \u03bcm, 1 cm length) is required. A GC column such as a DB-5MS, ZB-SMSi models, or equivalent phase, with a length of 30 m, an inner diameter of 0.25 mm and a film thickness of 1 \u03bcm is used. 7. The SPME HS parameters are set to the values indicated as follows:"}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": "example 10", "confidence": 0.9, "construct": {"method_text_verbatim": "5. Multiple glass capillaries are prepared in the same way and left to evaporate at ambient temperature for pre-determined periods of time, such as for example 10, 15, 30 mins, 1 hr, 2 hrs, 3 hrs, 4 hrs, 5 hrs, and up to 6 hrs, before being introduced to the headspace vial and sealed.", "panel_size": null, "property_name": "headspace_concentration_or_intensity", "scale": "hours_or_timepoint", "substrate": ["headspace"], "time_points": ["1 hr", "2 hrs", "3 hrs", "4 hrs", "5 hrs", "6 hrs"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "1 hr; 2 hrs; 3 hrs; 4 hrs; 5 hrs; 6 hrs", "patent_id": "US20160362630A1", "provenance": {"citation": "US20160362630A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20160362630A1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:0242", "units": "hours", "verbatim_quote": "5. Multiple glass capillaries are prepared in the same way and left to evaporate at ambient temperature for pre-determined periods of time, such as for example 10, 15, 30 mins, 1 hr, 2 hrs, 3 hrs, 4 hrs, 5 hrs, and up to 6 hrs, before being introduced to the headspace vial and sealed."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.7, "construct": {"method_text_verbatim": "Compositions disclosed in Tables 18(a)-18(d), 20, 21, and 22(a)-22(d) are applied to glass slides in accordance with the protocol described in the Method Section and a panel of 6-10 experienced panelists evaluate the perceived fragrance profile at initial time 0, then at various time points, typically 1 hour, 2 hours, 3 hours, 4 hours and 6 hours post application. Panelists are asked to score the compositions for the longevity and/or fidelity of the fragrance profile on a scale of 0 to 5, wherein 0 represents a no fragrance is detected and 5 represents a very strong fragrance intensity is detected. The results of the panelists are then averaged and discussed below.", "panel_size": null, "property_name": "fragrance_intensity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["1 hour", "2 hours", "3 hours", "4 hours", "6 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "6-10; 1 hour; 2 hours; 3 hours; 4 hours; 6 hours; 0 to 5", "patent_id": "US20160362630A1", "provenance": {"citation": "US20160362630A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20160362630A1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:3216", "units": "hours", "verbatim_quote": "Compositions disclosed in Tables 18(a)-18(d), 20, 21, and 22(a)-22(d) are applied to glass slides in accordance with the protocol described in the Method Section and a panel of 6-10 experienced panelists evaluate the perceived fragrance profile at initial time 0, then at various time points, typically 1 hour, 2 hours, 3 hours, 4 hours and 6 hours post application. Panelists are asked to score the compositions for the longevity and/or fidelity of the fragrance profile on a scale of 0 to 5, wherein 0 represents a no fragrance is detected and 5 represents a very strong fragrance intensity is detected. The results of the panelists are then averaged and discussed below."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.7, "construct": {"method_text_verbatim": "FIG. 2 shows the fragrance intensity profile of Composition A9 (as disclosed in Table 22(c)) as evaluated by 10 panelists, which comprises the substantially non-odorous fragrance modulator Bis-methoxy PEG-13 PEG-438/PPG-110 SMDI Copolymer (i.e., Expert Gel\u00ae 56) and the single fragrance material Indocolore. Addition of the substantially non-odorous fragrance modulator (Expert Gel\u00ae 56) maintains the intensity of the fragrance material for up to at least 6 hours whilst the control, Composition B9, in the absence of the substantially non-odorous fragrance modulator, drops in fragrance intensity profile much more over this time. The substantially non-odorous fragrance modulator acts to maintain the continued initial evaporation over time of the fragrance material. Statistical analysis using the Tukey correction for multiple comparisons confirms the statistically significant difference at 1, 3 and 6 hours (p<0.0001) at 95% significance level (i.e., p<0.05) at all these time points.", "panel_size": 10, "property_name": "fragrance_intensity", "scale": "percent", "substrate": null, "time_points": ["6 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "6 hours", "patent_id": "US20160362630A1", "provenance": {"citation": "US20160362630A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20160362630A1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:3218", "units": "hours", "verbatim_quote": "FIG. 2 shows the fragrance intensity profile of Composition A9 (as disclosed in Table 22(c)) as evaluated by 10 panelists, which comprises the substantially non-odorous fragrance modulator Bis-methoxy PEG-13 PEG-438/PPG-110 SMDI Copolymer (i.e., Expert Gel\u00ae 56) and the single fragrance material Indocolore. Addition of the substantially non-odorous fragrance modulator (Expert Gel\u00ae 56) maintains the intensity of the fragrance material for up to at least 6 hours whilst the control, Composition B9, in the absence of the substantially non-odorous fragrance modulator, drops in fragrance intensity profile much more over this time. The substantially non-odorous fragrance modulator acts to maintain the continued initial evaporation over time of the fragrance material. Statistical analysis using the Tukey correction for multiple comparisons confirms the statistically significant difference at 1, 3 and 6 hours (p<0.0001) at 95% significance level (i.e., p<0.05) at all these time points."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.7, "construct": {"method_text_verbatim": "FIG. 3 shows the fragrance intensity profile of Composition C9 (as disclosed in Table 22(c)) as evaluated by 9 panelists, which comprises the substantially non-odorous fragrance modulator propyl {4-[2-(diethylamino)-2-oxoethoxy]-3-methoxyphenyl}acetate (i.e., Kolliphor\u00ae EL) and the single fragrance material Dimethyl Benzyl Carbinol. Addition of the substantially non-odorous fragrance modulator (Kolliphor\u00ae EL) maintains the intensity of the fragrance material for up to at least 6 hours whilst the control, Composition D9, in the absence of the substantially non-odorous fragrance modulator, drops in fragrance intensity profile much more over this time. The substantially non-odorous fragrance modulator acts to maintain the reduced rate of evaporation over time of the fragrance material. Statistical analysis using the Tukey correction for multiple comparisons confirms the statistically significant difference at 1 hour (p<0.0001), 3 hours (p=0.0265) and 6 hours (p=0.0388) at 95% significance", "panel_size": 9, "property_name": "fragrance_intensity", "scale": "percent", "substrate": null, "time_points": ["6 hours", "1 hour", "3 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "6 hours; 1 hour; 3 hours", "patent_id": "US20160362630A1", "provenance": {"citation": "US20160362630A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20160362630A1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:3219", "units": "hours", "verbatim_quote": "FIG. 3 shows the fragrance intensity profile of Composition C9 (as disclosed in Table 22(c)) as evaluated by 9 panelists, which comprises the substantially non-odorous fragrance modulator propyl {4-[2-(diethylamino)-2-oxoethoxy]-3-methoxyphenyl}acetate (i.e., Kolliphor\u00ae EL) and the single fragrance material Dimethyl Benzyl Carbinol. Addition of the substantially non-odorous fragrance modulator (Kolliphor\u00ae EL) maintains the intensity of the fragrance material for up to at least 6 hours whilst the control, Composition D9, in the absence of the substantially non-odorous fragrance modulator, drops in fragrance intensity profile much more over this time. The substantially non-odorous fragrance modulator acts to maintain the reduced rate of evaporation over time of the fragrance material. Statistical analysis using the Tukey correction for multiple comparisons confirms the statistically significant difference at 1 hour (p<0.0001), 3 hours (p=0.0265) and 6 hours (p=0.0388) at 95% significance level (i.e., p<0.05) at all these time points."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.7, "construct": {"method_text_verbatim": "FIG. 4 shows the fragrance intensity profile of Composition E9 (as disclosed in Table 22(c)) as evaluated by 9 panelists, which comprises the substantially non-odorous fragrance modulator propyl {4-[2-(diethylamino)-2-oxoethoxy]-3-methoxyphenyl}acetate (i.e., Kolliphor\u00ae EL) and the single fragrance material Eugenol. Addition of the substantially non-odorous fragrance modulator (Kolliphor\u00ae EL) maintains the intensity of the fragrance material for up to at least 6 hours whilst the control, Composition F9, in the absence of the substantially non-odorous fragrance modulator, drops in fragrance intensity profile much more over this time. The substantially non-odorous fragrance modulator acts to supress the initial display of Eugenol and then maintains that continued initial evaporation over time. Statistical analysis using the Tukey correction for multiple comparisons confirms the statistically significant difference at 0 hours (p=0.0025), 1 hour (p<0.0001), 3 hours (p<0.0001) and 6 hours (", "panel_size": 9, "property_name": "fragrance_intensity", "scale": "percent", "substrate": null, "time_points": ["6 hours", "0 hours", "1 hour", "3 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "6 hours; 0 hours; 1 hour; 3 hours", "patent_id": "US20160362630A1", "provenance": {"citation": "US20160362630A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20160362630A1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:3220", "units": "hours", "verbatim_quote": "FIG. 4 shows the fragrance intensity profile of Composition E9 (as disclosed in Table 22(c)) as evaluated by 9 panelists, which comprises the substantially non-odorous fragrance modulator propyl {4-[2-(diethylamino)-2-oxoethoxy]-3-methoxyphenyl}acetate (i.e., Kolliphor\u00ae EL) and the single fragrance material Eugenol. Addition of the substantially non-odorous fragrance modulator (Kolliphor\u00ae EL) maintains the intensity of the fragrance material for up to at least 6 hours whilst the control, Composition F9, in the absence of the substantially non-odorous fragrance modulator, drops in fragrance intensity profile much more over this time. The substantially non-odorous fragrance modulator acts to supress the initial display of Eugenol and then maintains that continued initial evaporation over time. Statistical analysis using the Tukey correction for multiple comparisons confirms the statistically significant difference at 0 hours (p=0.0025), 1 hour (p<0.0001), 3 hours (p<0.0001) and 6 hours (p<0.0001) at 95% significance level (i.e., p<0.05) at all time points."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.7, "construct": {"method_text_verbatim": "FIG. 5 shows the fragrance intensity profile of Composition G9 (as disclosed in Table 22(c)) as evaluated by 9 panelists, which comprises the substantially non-odorous fragrance modulator propyl {4-[2-(diethylamino)-2-oxoethoxy]-3-methoxyphenyl}acetate (i.e., Kolliphor\u00ae EL) and the single fragrance material Phenethyl alcohol (PEA). Addition of the substantially non-odorous fragrance modulator (Kolliphor\u00ae EL) maintains the intensity of the fragrance material from 1 hour to 3 hours whilst the control, Composition H9, in the absence of the substantially non-odorous fragrance modulator, drops in fragrance intensity profile over this time. The substantially non-odorous fragrance modulator acts to maintain the reduced rate of evaporation over time of the fragrance material. Statistical analysis using the Tukey correction for multiple comparisons confirms the statistically significant difference at 1 hour (p<0.0001) at 95% significance level (i.e., p<0.05) and at 3 hours (p=0.0876) at 90% sig", "panel_size": 9, "property_name": "fragrance_intensity", "scale": "percent", "substrate": null, "time_points": ["1 hour", "3 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "1 hour; 3 hours", "patent_id": "US20160362630A1", "provenance": {"citation": "US20160362630A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20160362630A1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:3221", "units": "hours", "verbatim_quote": "FIG. 5 shows the fragrance intensity profile of Composition G9 (as disclosed in Table 22(c)) as evaluated by 9 panelists, which comprises the substantially non-odorous fragrance modulator propyl {4-[2-(diethylamino)-2-oxoethoxy]-3-methoxyphenyl}acetate (i.e., Kolliphor\u00ae EL) and the single fragrance material Phenethyl alcohol (PEA). Addition of the substantially non-odorous fragrance modulator (Kolliphor\u00ae EL) maintains the intensity of the fragrance material from 1 hour to 3 hours whilst the control, Composition H9, in the absence of the substantially non-odorous fragrance modulator, drops in fragrance intensity profile over this time. The substantially non-odorous fragrance modulator acts to maintain the reduced rate of evaporation over time of the fragrance material. Statistical analysis using the Tukey correction for multiple comparisons confirms the statistically significant difference at 1 hour (p<0.0001) at 95% significance level (i.e., p<0.05) and at 3 hours (p=0.0876) at 90% significance level (i.e., p<0.1)."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.7, "construct": {"method_text_verbatim": "Panelists are asked to score the compositions for the intensity of the fragrance on a scale of 0 to 5, wherein 0 represents a no fragrance intensity is detected and 5 represents a very strong fragrance intensity is detected. The results of the panel test are then averaged. The results show the effect of the substantially non-odorous fragrance modulator and diamond constructed fragrance materials for any one of the inventive Compositions A1, A2, A3, A4, A5, D1, D2, D4, G1, G2, G4, J1, J2, J4, M1, and M2 on fragrance profile longevity versus control Compositions C2, C3, C4, C5, F1, F2, F4, I1, I2, I4, L1, L2, L4, O1, and O2 in the absence of the substantially non-odorous modulator. Alternatively, the results show the effect of the substantially non-odorous fragrance modulator and diamond constructed fragrance materials for any one of the inventive Compositions A1, A2, A3, A4, A5, D1, D2, D4, G1, G2, G4, J1, J2, J4, M1, and M2 on fragrance profile longevity versus traditional Compositions", "panel_size": null, "property_name": "fragrance_intensity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["6 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "0 to 5; 6 hours", "patent_id": "US20160362630A1", "provenance": {"citation": "US20160362630A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20160362630A1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:3223", "units": "hours", "verbatim_quote": "Panelists are asked to score the compositions for the intensity of the fragrance on a scale of 0 to 5, wherein 0 represents a no fragrance intensity is detected and 5 represents a very strong fragrance intensity is detected. The results of the panel test are then averaged. The results show the effect of the substantially non-odorous fragrance modulator and diamond constructed fragrance materials for any one of the inventive Compositions A1, A2, A3, A4, A5, D1, D2, D4, G1, G2, G4, J1, J2, J4, M1, and M2 on fragrance profile longevity versus control Compositions C2, C3, C4, C5, F1, F2, F4, I1, I2, I4, L1, L2, L4, O1, and O2 in the absence of the substantially non-odorous modulator. Alternatively, the results show the effect of the substantially non-odorous fragrance modulator and diamond constructed fragrance materials for any one of the inventive Compositions A1, A2, A3, A4, A5, D1, D2, D4, G1, G2, G4, J1, J2, J4, M1, and M2 on fragrance profile longevity versus traditional Compositions B1, B2, B3, B4, B5, E1, E2, E4, H1, H2, H4, K1, K2, K4, N1, and N2 in the presence of the substantially non-odorous fragrance modulator. Fragrance profile longevity, particularly intensity of the characters attributable to the volatile fragrance materials are maintained for up to at least 6 hours in the presence of the substantially non-odorous fragrance modulator whilst it drops in the absence of the substantially non-odorous fragrance modulator."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": "Example 4b", "confidence": 0.75, "construct": {"method_text_verbatim": "FIG. 6 provides the fragrance intensity profile of Composition A4 (as disclosed in Table 18(d)), which comprises the substantially non-odorous fragrance modulator PPG-20 Methyl Glucose Ether (i.e., Glucam\u2122 P-20) and the Diamond Floral Magnifica Fragrance Example 4b. Addition of the substantially non-odorous fragrance modulator Glucam\u2122 P-20 maintains the intensity of the fragrance material for up to 6 hours. As compared to the control Composition C4, in the absence of the substantially non-odorous fragrance modulator Glucam\u2122 P-20, and comprising the Traditional Floral Magnifica Fragrance Example 4a drops in fragrance intensity over the 6 hours.", "panel_size": null, "property_name": "fragrance_intensity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["6 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "6 hours", "patent_id": "US20160362630A1", "provenance": {"citation": "US20160362630A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20160362630A1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:3224", "units": "hours", "verbatim_quote": "FIG. 6 provides the fragrance intensity profile of Composition A4 (as disclosed in Table 18(d)), which comprises the substantially non-odorous fragrance modulator PPG-20 Methyl Glucose Ether (i.e., Glucam\u2122 P-20) and the Diamond Floral Magnifica Fragrance Example 4b. Addition of the substantially non-odorous fragrance modulator Glucam\u2122 P-20 maintains the intensity of the fragrance material for up to 6 hours. As compared to the control Composition C4, in the absence of the substantially non-odorous fragrance modulator Glucam\u2122 P-20, and comprising the Traditional Floral Magnifica Fragrance Example 4a drops in fragrance intensity over the 6 hours."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": "Example 5b", "confidence": 0.75, "construct": {"method_text_verbatim": "FIG. 7 provides the fragrance intensity profile of Composition A4 (as disclosed in Table 18(d)), which comprises the substantially non-odorous fragrance modulator PPG-20 Methyl Glucose Ether (i.e., Glucam\u2122 P-20) and the Diamond Muguesia Magnifica Fragrance Example 5b. Addition of the substantially non-odorous fragrance modulator Glucam\u2122 P-20 maintains the intensity of the fragrance material for up to 6 hours. As compared to the control Composition C4, in the absence of the substantially non-odorous fragrance modulator Glucam\u2122 P-20, and comprising the Traditional Muguesia Magnifica Fragrance Example 5a drops in fragrance intensity over the 6 hours.", "panel_size": null, "property_name": "fragrance_intensity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["6 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "6 hours", "patent_id": "US20160362630A1", "provenance": {"citation": "US20160362630A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20160362630A1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:3225", "units": "hours", "verbatim_quote": "FIG. 7 provides the fragrance intensity profile of Composition A4 (as disclosed in Table 18(d)), which comprises the substantially non-odorous fragrance modulator PPG-20 Methyl Glucose Ether (i.e., Glucam\u2122 P-20) and the Diamond Muguesia Magnifica Fragrance Example 5b. Addition of the substantially non-odorous fragrance modulator Glucam\u2122 P-20 maintains the intensity of the fragrance material for up to 6 hours. As compared to the control Composition C4, in the absence of the substantially non-odorous fragrance modulator Glucam\u2122 P-20, and comprising the Traditional Muguesia Magnifica Fragrance Example 5a drops in fragrance intensity over the 6 hours."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": "Example 4b", "confidence": 0.75, "construct": {"method_text_verbatim": "FIG. 8 provides the fragrance intensity profile of Composition A2 (as disclosed in Table 18(b)), which comprises 15 wt % substantially non-odorous fragrance modulator Diisobutyl Adipate and 7 wt % Diamond Floral Magnifica Fragrance Example 4b. Addition of the substantially non-odorous fragrance modulator Diisobutyl Adipate maintains the intensity of the fragrance material for up to 6 hours. As compared to the control Composition C2, in the absence of the substantially non-odorous fragrance modulator Diisobutyl Adipate, and comprising 7 wt % Traditional Floral Magnifica Fragrance Example 4a drops in fragrance intensity over the 6 hours.", "panel_size": null, "property_name": "fragrance_intensity", "scale": "percent", "substrate": null, "time_points": ["6 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "6 hours", "patent_id": "US20160362630A1", "provenance": {"citation": "US20160362630A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20160362630A1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:3226", "units": "hours", "verbatim_quote": "FIG. 8 provides the fragrance intensity profile of Composition A2 (as disclosed in Table 18(b)), which comprises 15 wt % substantially non-odorous fragrance modulator Diisobutyl Adipate and 7 wt % Diamond Floral Magnifica Fragrance Example 4b. Addition of the substantially non-odorous fragrance modulator Diisobutyl Adipate maintains the intensity of the fragrance material for up to 6 hours. As compared to the control Composition C2, in the absence of the substantially non-odorous fragrance modulator Diisobutyl Adipate, and comprising 7 wt % Traditional Floral Magnifica Fragrance Example 4a drops in fragrance intensity over the 6 hours."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": "Example 5b", "confidence": 0.75, "construct": {"method_text_verbatim": "FIG. 9 provides the fragrance intensity profile of Composition A2 (as disclosed in Table 18(b)), which comprises 15 wt % substantially non-odorous fragrance modulator Diisobutyl Adipate and 7 wt % Diamond Muguesia Magnifica Fragrance Example 5b. Addition of the substantially non-odorous fragrance modulator Diisobutyl Adipate maintains the intensity of the fragrance material for up to 6 hours. As compared to the control Composition C2, in the absence of the substantially non-odorous fragrance modulator Diisobutyl Adipate, and comprising 7 wt % Traditional Muguesia Magnifica Fragrance Example 5a drops in fragrance intensity over the 6 hours.", "panel_size": null, "property_name": "fragrance_intensity", "scale": "percent", "substrate": null, "time_points": ["6 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "6 hours", "patent_id": "US20160362630A1", "provenance": {"citation": "US20160362630A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20160362630A1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:3227", "units": "hours", "verbatim_quote": "FIG. 9 provides the fragrance intensity profile of Composition A2 (as disclosed in Table 18(b)), which comprises 15 wt % substantially non-odorous fragrance modulator Diisobutyl Adipate and 7 wt % Diamond Muguesia Magnifica Fragrance Example 5b. Addition of the substantially non-odorous fragrance modulator Diisobutyl Adipate maintains the intensity of the fragrance material for up to 6 hours. As compared to the control Composition C2, in the absence of the substantially non-odorous fragrance modulator Diisobutyl Adipate, and comprising 7 wt % Traditional Muguesia Magnifica Fragrance Example 5a drops in fragrance intensity over the 6 hours."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.6, "construct": {"method_text_verbatim": "Without wishing to be bound by theory, it is believed that the substantially non-odorous fragrance modulator acts to maintain the continued evaporation over time of the fragrance materials, particular the volatile fragrance materials. The effects of the improved fragrance profile longevity of the present invention are noticeable at, any one of, 1, 3 and 6 hours post application.", "panel_size": null, "property_name": "longevity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["6 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "6 hours", "patent_id": "US20160362630A1", "provenance": {"citation": "US20160362630A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20160362630A1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:3229", "units": "hours", "verbatim_quote": "Without wishing to be bound by theory, it is believed that the substantially non-odorous fragrance modulator acts to maintain the continued evaporation over time of the fragrance materials, particular the volatile fragrance materials. The effects of the improved fragrance profile longevity of the present invention are noticeable at, any one of, 1, 3 and 6 hours post application."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.6, "construct": {"method_text_verbatim": "The test demonstrates the character retention over time of a fragrance composition. The results show the effect of the substantially non-odorous fragrance modulator and fragrance materials in a diamond construction for any one of the inventive Compositions A1, A2, A3, A4, A5, D1, D2, D4, G1, G2, G4, J1, J2, J4, M1, and M2 on fragrance profile versus control Compositions C1, C2, C3, C4, C5, F1, F2, F4, I1, I2, I4, L1, L2, L4, O1, and O2 in the absence of the substantially non-odorous fragrance modulator. Alternatively, results show the effect of the substantially non-odorous fragrance modulator and fragrance materials in a diamond construction for any one of the inventive Compositions A1, A2, A3, A4, A5, D1, D2, D4, G1, G2, G4, J1, J2, J4, M1, and M2 on fragrance profile longevity versus traditional Compositions B1, B2, B3, B4, B5, E1, E2, E4, H1, H2, H4, K1, K2, K4, N1, and N2 in the presence of the substantially non-odorous fragrance modulator. Fragrance profile fidelity, particularly", "panel_size": null, "property_name": "longevity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["1 hour"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "1 hour", "patent_id": "US20160362630A1", "provenance": {"citation": "US20160362630A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20160362630A1/en"}, "pub_date": "2016-06-07", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:3255", "units": "hours", "verbatim_quote": "The test demonstrates the character retention over time of a fragrance composition. The results show the effect of the substantially non-odorous fragrance modulator and fragrance materials in a diamond construction for any one of the inventive Compositions A1, A2, A3, A4, A5, D1, D2, D4, G1, G2, G4, J1, J2, J4, M1, and M2 on fragrance profile versus control Compositions C1, C2, C3, C4, C5, F1, F2, F4, I1, I2, I4, L1, L2, L4, O1, and O2 in the absence of the substantially non-odorous fragrance modulator. Alternatively, results show the effect of the substantially non-odorous fragrance modulator and fragrance materials in a diamond construction for any one of the inventive Compositions A1, A2, A3, A4, A5, D1, D2, D4, G1, G2, G4, J1, J2, J4, M1, and M2 on fragrance profile longevity versus traditional Compositions B1, B2, B3, B4, B5, E1, E2, E4, H1, H2, H4, K1, K2, K4, N1, and N2 in the presence of the substantially non-odorous fragrance modulator. Fragrance profile fidelity, particularly of floral characters attributable to the volatile fragrance materials are maintained for up to at least 1 hour in the presence of the substantially non-odorous fragrance modulator whilst it drops in the absence of the substantially non-odorous fragrance modulator."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.6, "construct": {"method_text_verbatim": "There are at least one of several drawbacks to the above described classical formulation approach. Firstly, classification of fragrance materials by their aromas is subjective and therefore results in inconsistency with the construction of the fragrance profile under classical fragrance pyramid construction rules. Secondly, the perceived intensity of the fragrance profile of the conventional perfume compositions, particularly those aromas attributable to the more volatile fragrance materials, decreases rapidly over time due to their quick evaporation. Accordingly, conventional perfume compositions will typically change their overall fragrance profile over time. This is a problem because it is desirable to maintain \"fragrance profile fidelity\" over time. In other words, it is desirable to maintain the same or substantively similar fragrance profile for a commercial fragrance over time, particularly over long periods of time (at least 4 hrs, 6 hrs, or even 8 hours after application). Thi", "panel_size": null, "property_name": "fragrance_intensity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["4 hrs", "6 hrs", "8 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "4 hrs; 6 hrs; 8 hours", "patent_id": "EP3103431A1", "provenance": {"citation": "EP3103431A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3103431A1/en"}, "pub_date": "2015-06-12", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:5", "units": "hours", "verbatim_quote": "There are at least one of several drawbacks to the above described classical formulation approach. Firstly, classification of fragrance materials by their aromas is subjective and therefore results in inconsistency with the construction of the fragrance profile under classical fragrance pyramid construction rules. Secondly, the perceived intensity of the fragrance profile of the conventional perfume compositions, particularly those aromas attributable to the more volatile fragrance materials, decreases rapidly over time due to their quick evaporation. Accordingly, conventional perfume compositions will typically change their overall fragrance profile over time. This is a problem because it is desirable to maintain \"fragrance profile fidelity\" over time. In other words, it is desirable to maintain the same or substantively similar fragrance profile for a commercial fragrance over time, particularly over long periods of time (at least 4 hrs, 6 hrs, or even 8 hours after application). Thirdly, with the classical fragrance pyramid construction, the possible types of fragrance profiles have been somewhat limited. The consequence of using base notes at high levels is that many fragrance dry-downs appear repetitive, boring, non-memorable and un-interesting to consumers. However, if base notes are reduced or excluded then the fragrance intensity weakens over time and does not last for a sufficient duration. Lastly, it is generally accepted that some consumers desire prolonged intensity of select aromas, particularly the floral, spicy or aromatic aromas derived from the heart notes. Unfortunately, the consequence of using high levels of base notes is that they may impart particularly undesirable aroma characters, such as for example, musky, woody, ambery, warm and sweet, which overpower and dominate the more desirable fragrance characters over time, particular over long periods of time. Thus, the unique challenge remains of selectively extending the more desirable aromas attributable from the heart and/or top notes, particularly the heart notes, and even more particularly extending these desirable aromas over long periods of time,"}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.6, "construct": {"method_text_verbatim": "Thus, it is an advantage of the present invention to provide new rules for objectively classifying fragrance materials according to their volatility using their their vapor pressures defined at suitable temperature, instead of their aromas. The new rules operate irrespective of the perfumers performing the classification. In particular, the new rules classify the fragrance materials into low, moderate or high volatile fragrance materials for formulating into fragrance mixtures, particularly ones having a diamond construction. It is a further advantage of the present invention to provide compositions having improved fidelity to the perceived fragrance profile over time. It is yet a further advantage to provide a composition, wherein the aroma attributable to moderate and high volatile fragrance materials, particularly the moderate volatile fragrance materials, remains significantly consistent from its initial impression to the end. It is yet a further advantage to provide compositions h", "panel_size": null, "property_name": "longevity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["8 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "8 hours", "patent_id": "EP3103431A1", "provenance": {"citation": "EP3103431A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3103431A1/en"}, "pub_date": "2015-06-12", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:10", "units": "hours", "verbatim_quote": "Thus, it is an advantage of the present invention to provide new rules for objectively classifying fragrance materials according to their volatility using their their vapor pressures defined at suitable temperature, instead of their aromas. The new rules operate irrespective of the perfumers performing the classification. In particular, the new rules classify the fragrance materials into low, moderate or high volatile fragrance materials for formulating into fragrance mixtures, particularly ones having a diamond construction. It is a further advantage of the present invention to provide compositions having improved fidelity to the perceived fragrance profile over time. It is yet a further advantage to provide a composition, wherein the aroma attributable to moderate and high volatile fragrance materials, particularly the moderate volatile fragrance materials, remains significantly consistent from its initial impression to the end. It is yet a further advantage to provide compositions having improved longevity of the perceived fragrance profile, preferably the aromas attributable from the moderate or high volatile fragrance materials, particularly the moderate volatile fragrance material. It is yet a further advantage to provide compositions having stable quality of end product (e.g., fragrance profile, visual appearance) substantially comparable to the classical fragrance pyramid three-tiered structure, preferably even after three months storage at 40 \u00b0C. It is yet a further advantage to be able to create new to the world fragrance profiles wherein one, or several, well-recognized moderate volatile fragrance material characters, are maintained over time, preferably for long periods of time (e.g., > 4, 6, or even 8 hours)."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.85, "construct": {"method_text_verbatim": "The present invention provides a method for imparting, intensifying, or modifying an odour on human skin or human hair, comprising applying to human skin and/or human hair the composition of the present invention. It is preferred that the method is for imparting, intensifying or modifying the longevity of a floral aroma or aromatic/spicy aroma on human skin or human hair, wherein the perceived intensity of the floral aroma or aromatic/spicy aroma at 1 hr, 2 hrs, 3 hrs or 6 hrs after application is greater than a control composition that does not include the substantially non-odorous fragrance modulator as determined by the panel method as disclosed herein.", "panel_size": null, "property_name": "longevity", "scale": "hours_or_timepoint", "substrate": ["hair", "skin"], "time_points": ["1 hr", "2 hrs", "3 hrs", "6 hrs"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "1 hr; 2 hrs; 3 hrs; 6 hrs", "patent_id": "EP3103431A1", "provenance": {"citation": "EP3103431A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3103431A1/en"}, "pub_date": "2015-06-12", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:84", "units": "hours", "verbatim_quote": "The present invention provides a method for imparting, intensifying, or modifying an odour on human skin or human hair, comprising applying to human skin and/or human hair the composition of the present invention. It is preferred that the method is for imparting, intensifying or modifying the longevity of a floral aroma or aromatic/spicy aroma on human skin or human hair, wherein the perceived intensity of the floral aroma or aromatic/spicy aroma at 1 hr, 2 hrs, 3 hrs or 6 hrs after application is greater than a control composition that does not include the substantially non-odorous fragrance modulator as determined by the panel method as disclosed herein."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.85, "construct": {"method_text_verbatim": "At the testing facility, 50 \u00b5L samples of the compositions or the controls are applied to glass slides and placed on a hot plate at 32 \u00b0C to represent skin temperature for varying durations. The panelists are asked to evaluate the perceived fragrance profile (intensity and/or character) from each pair of samples, i.e. , that of the test composition of the present invention vs. the corresponding control, at time 0 and later time points (1, 2, 3 4 and 6 hours post application) as the fragrance profile evolves. Their assessments are recorded. Panelists are selected from individuals who are either trained to evaluate fragrances according to the scales below or who have experience of fragrance evaluation in the industry.", "panel_size": null, "property_name": "duration", "scale": "hours_or_timepoint", "substrate": ["skin"], "time_points": ["6 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "6 hours", "patent_id": "EP3103431A1", "provenance": {"citation": "EP3103431A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3103431A1/en"}, "pub_date": "2015-06-12", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:863", "units": "hours", "verbatim_quote": "At the testing facility, 50 \u00b5L samples of the compositions or the controls are applied to glass slides and placed on a hot plate at 32 \u00b0C to represent skin temperature for varying durations. The panelists are asked to evaluate the perceived fragrance profile (intensity and/or character) from each pair of samples, i.e. , that of the test composition of the present invention vs. the corresponding control, at time 0 and later time points (1, 2, 3 4 and 6 hours post application) as the fragrance profile evolves. Their assessments are recorded. Panelists are selected from individuals who are either trained to evaluate fragrances according to the scales below or who have experience of fragrance evaluation in the industry."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.55, "construct": {"method_text_verbatim": "The panelists are asked to give a score on a scale of 0 to 5 for perceived fragrance intensity according to the odour intensity scale set out in Table 4 herein below. Table 4 - Odour Intensity Scale Score Fragrance Intensity 0 None 1 Very Weak 2 Weak 3 Moderate 4 Strong 5 Very Strong", "panel_size": null, "property_name": "fragrance_intensity", "scale": "numeric_unknown", "substrate": null, "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "0 to 5", "patent_id": "EP3103431A1", "provenance": {"citation": "EP3103431A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3103431A1/en"}, "pub_date": "2015-06-12", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:864", "units": null, "verbatim_quote": "The panelists are asked to give a score on a scale of 0 to 5 for perceived fragrance intensity according to the odour intensity scale set out in Table 4 herein below. Table 4 - Odour Intensity Scale Score Fragrance Intensity 0 None 1 Very Weak 2 Weak 3 Moderate 4 Strong 5 Very Strong"}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": "example 20", "confidence": 0.75, "construct": {"method_text_verbatim": "The following test is carried out to demonstrate the improved or enhanced longevity of a fragrance profile of a composition of the present invention vs. a control. In particular, the test measures the effect of a substantially non-odorous fragrance modulator on the evaporation rate of one or more fragrance materials formulated in a composition. The evaporation response of the fragrance materials to the modulator, as a function of time, is measured through the use of gas chromatography (\"GC\"). 1. A test composition comprising the substantially non-odorous fragrance modulator with either: (i) a fragrance material, or (ii) a blend of fragrance materials is made. The inventive compositions also contain high purity ethanol, such as Hayman 100%EP/BP grade, and deionised water. Samples tests compositions are provided in Tables 18 and 19. All of the ingredients are admixed until evenly distributed in the test compositions. 2. A control composition, without the substantially non-odorous fragran", "panel_size": null, "property_name": "longevity", "scale": "percent", "substrate": null, "time_points": ["1 hr", "2 hrs", "3 hrs", "4 hrs", "5 hrs", "6 hrs", "8 hrs", "12 hrs"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "100%; 90 to 95; 99 to 99.75; 1 hr; 2 hrs; 3 hrs; 4 hrs; 5 hrs; 6 hrs; 8 hrs; 12 hrs; 5 to 10; 25 to 40", "patent_id": "EP3103431A1", "provenance": {"citation": "EP3103431A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3103431A1/en"}, "pub_date": "2015-06-12", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:887", "units": "hours", "verbatim_quote": "The following test is carried out to demonstrate the improved or enhanced longevity of a fragrance profile of a composition of the present invention vs. a control. In particular, the test measures the effect of a substantially non-odorous fragrance modulator on the evaporation rate of one or more fragrance materials formulated in a composition. The evaporation response of the fragrance materials to the modulator, as a function of time, is measured through the use of gas chromatography (\"GC\"). 1. A test composition comprising the substantially non-odorous fragrance modulator with either: (i) a fragrance material, or (ii) a blend of fragrance materials is made. The inventive compositions also contain high purity ethanol, such as Hayman 100%EP/BP grade, and deionised water. Samples tests compositions are provided in Tables 18 and 19. All of the ingredients are admixed until evenly distributed in the test compositions. 2. A control composition, without the substantially non-odorous fragrance modulator or with normal or high levels of the low volatile fragrance materials, is made in a similar manner to Step 1. Sample control compositions are provided in Tables 18 and 19. 3. An internal standard is needed to correct for variations of the amount of composition dispensed in the evaporation test as well as loss during the GC analysis. The internal standard has a vapor pressure of less than 0.001 Torr at 25 \u00b0C and is soluble in the composition and fragrance material. Suitable non-limiting examples of internal standard include: isopropyl myristate or triethyl citrate. The internal standard and fragrance material are admixed until evenly distributed at a level of 90 to 95 parts by weight of fragrance material and the required amount of internal standard to reach 100 parts. This mixture is then use to prepare the sample compositions in Step 1 and 2. Alternatively, the internal standard and test or control composition are admixed until evenly distributed at a level of 99 to 99.75 parts by weight of composition and the required amount of internal standard to reach 100 parts. This resultant solution is used in subsequent steps. 4. A hotplate is set to a temperature of 32 \u00b0C. An aluminum container, such as TA Instruments T-Zero\u2122 pan or lids, or a Cole Parmer Micro aluminum weighing dish, with dimensions 12 mm (L) x 4 mm (W) x 2.7 mm (H), is placed on the hotplate. 20 \u00b5L of the test or control composition is introduced in the aluminum container using a micropipette. Alternatively, the aluminum container may be filled with the test or control composition to its full capacity. The time at which this takes place is determined to be time zero ( i.e., T=0). Multiple aluminum containers are prepared and left at the set temperature for pre-determined periods of time, such as for example 20 mins, 1 hr, 2 hrs, 3 hrs, 4 hrs, 5 hrs, 6 hrs, 8 hrs and up to 12 hrs. 5. The aluminum container is removed from the hotplate at the end of the pre-determined time period and transferred by being inserted into a 4 mL glass vial already containing at least 2 mL of highly volatile solvent, such as high purity ethanol or hexane. 6. The glass vial is mixed using a Heidolph multi REAX shaker for 5 to 10 mins to extract the fragrance materials into the solvent phase. 1.5mL of the resultant solution is transferred to a 2 mL GC vial. 7. The GC vial is analysed on an Agilent GC system 6890B equipped with an autosampler, or equivalent. A GC column such as a DB-5 or Rxi-5 SilMS model, with a length of 30 m, an inner diameter of 0.25 mm and a film thickness of 1 \u00b5m is used. The GC parameters are set to the values indicated as follows: Table 5(iii) - GC Parameters Injector temperature: 270 \u00b0C Initial gas velocity: 25 to 40 cm/sec (for Helium as the carrier gas) Initial oven temperature: 50 \u00b0C Temperature ramp: 8 \u00b0C/min Final oven temperature: 310 \u00b0C Gas chromatography with flame ionization detection (\"FID\") or with mass spectrometry (\"MS\") can be used for the identification and quantification of fragrance material in the compositions. Either detection system can be used in conjunction with GC. The column dimensions as well as GC settings described in this method, such as injector temperature, carrier gas velocity, temperature ramp and final oven temperature can be adjusted to optimize the response of the fragrance material and internal standard being monitored. The detection system settings, such as FID gas flows and temperature or MS parameters, should be optimized by a trained analyst to enable the precise detection and quantification of the analytes of interest. 8. The peak area of the fragrance material and internal standard are recorded. The peak area ratio of the fragrance material and the internal standard is calculated at each time point for each sample composition and the % loss from T=0 calculated. Significance is determined by comparison with the % loss for the same fragrance material or fragrance mixture in the control composition."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.7, "construct": {"method_text_verbatim": "Compositions disclosed in Tables 18-21 are applied to glass slides in accordance with the protocol described in the Method Section and a panel of 10 experienced panelists evaluate the perceived fragrance profile at initial time 0, then at various time points, typically 1 hour, 2 hours, 3 hours, 4 hours and 6 hours post application. Panellists are asked to score the compositions for the longevity and/or fidelity of the fragrance profile on a scale of 0 to 5, wherein 0 represents a no fragrance is detected and 5 represents a very strong fragrance intensity is detected. The results of the panellists are then averaged and discussed below.", "panel_size": null, "property_name": "fragrance_intensity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["1 hour", "2 hours", "3 hours", "4 hours", "6 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "18-21; 1 hour; 2 hours; 3 hours; 4 hours; 6 hours; 0 to 5", "patent_id": "EP3103431A1", "provenance": {"citation": "EP3103431A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3103431A1/en"}, "pub_date": "2015-06-12", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:1317", "units": "hours", "verbatim_quote": "Compositions disclosed in Tables 18-21 are applied to glass slides in accordance with the protocol described in the Method Section and a panel of 10 experienced panelists evaluate the perceived fragrance profile at initial time 0, then at various time points, typically 1 hour, 2 hours, 3 hours, 4 hours and 6 hours post application. Panellists are asked to score the compositions for the longevity and/or fidelity of the fragrance profile on a scale of 0 to 5, wherein 0 represents a no fragrance is detected and 5 represents a very strong fragrance intensity is detected. The results of the panellists are then averaged and discussed below."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.7, "construct": {"method_text_verbatim": "Panellists are asked to score the compositions for the intensity of the fragrance on a scale of 0 to 5, wherein 0 represents no fragrance intensity is detected and 5 represents a very strong fragrance intensity is detected. The results of the panel test are then averaged. The results show the effect of the substantially non-odorous fragrance modulator and reduced levels of low volatile fragrance materials for Compositions A, D, G, J and M on fragrance profile longevity and fidelity. Fragrance profile longevity, particularly intensity of the aromas attributable to the volatile fragrance materials are maintained for up to at least 6 hours in the presence of the substantially non-odorous fragrance modulator whilst it drops in the absence of the substantially non-odorous fragrance modulator. Without wishing to be bound by theory, it is believed that the substantially non-odorous fragrance modulator acts to maintain the continued evaporation over time of the fragrance materials, particular ", "panel_size": null, "property_name": "fragrance_intensity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["6 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "0 to 5; 6 hours", "patent_id": "EP3103431A1", "provenance": {"citation": "EP3103431A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3103431A1/en"}, "pub_date": "2015-06-12", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:1327", "units": "hours", "verbatim_quote": "Panellists are asked to score the compositions for the intensity of the fragrance on a scale of 0 to 5, wherein 0 represents no fragrance intensity is detected and 5 represents a very strong fragrance intensity is detected. The results of the panel test are then averaged. The results show the effect of the substantially non-odorous fragrance modulator and reduced levels of low volatile fragrance materials for Compositions A, D, G, J and M on fragrance profile longevity and fidelity. Fragrance profile longevity, particularly intensity of the aromas attributable to the volatile fragrance materials are maintained for up to at least 6 hours in the presence of the substantially non-odorous fragrance modulator whilst it drops in the absence of the substantially non-odorous fragrance modulator. Without wishing to be bound by theory, it is believed that the substantially non-odorous fragrance modulator acts to maintain the continued evaporation over time of the fragrance materials, particular the volatile fragrance materials. The effect of the improved fragrance profile longevity of the present invention are noticeable at 1, 3 and 6 hours. Statistical analysis for multiple comparisons confirm the statistically significant difference between the 2 products at various time points."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.55, "construct": {"method_text_verbatim": "Panellists are asked to score the compositions for the intensity of the fragrance on a scale of 0 to 5, wherein 0 represents a no fragrance intensity is detected and 5 represents a very strong fragrance intensity is detected. The results of the panel test are then averaged. The results show the effect of the substantially non-odorous fragrance modulator and excessive levels of low volatile fragrance materials for Compositions B, E, H, K and N on fragrance profile longevity and fidelity. Two outcomes are observed: (i) either the fragrance profile longevity is unaffected by the addition of the substantially non-odorous fragrance modulator (There are no statistical differences between the 2 products.) or (ii) the fragrance profile appears to be suppressed with a loss of strength (data not shown). Panellists are also asked to score the Compositions B, E, H, K and N for the dominance of the floral aromas on a scale of 0 to 3 wherein 0 represents not detectable and 3 represents it being the ", "panel_size": null, "property_name": "fragrance_intensity", "scale": "hours_or_timepoint", "substrate": null, "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "0 to 5; 0 to 3", "patent_id": "EP3103431A1", "provenance": {"citation": "EP3103431A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3103431A1/en"}, "pub_date": "2015-06-12", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:1330", "units": null, "verbatim_quote": "Panellists are asked to score the compositions for the intensity of the fragrance on a scale of 0 to 5, wherein 0 represents a no fragrance intensity is detected and 5 represents a very strong fragrance intensity is detected. The results of the panel test are then averaged. The results show the effect of the substantially non-odorous fragrance modulator and excessive levels of low volatile fragrance materials for Compositions B, E, H, K and N on fragrance profile longevity and fidelity. Two outcomes are observed: (i) either the fragrance profile longevity is unaffected by the addition of the substantially non-odorous fragrance modulator (There are no statistical differences between the 2 products.) or (ii) the fragrance profile appears to be suppressed with a loss of strength (data not shown). Panellists are also asked to score the Compositions B, E, H, K and N for the dominance of the floral aromas on a scale of 0 to 3 wherein 0 represents not detectable and 3 represents it being the dominant character. The results of the panel test are then averaged. The results show the effect of the substantially non-odorous fragrance modulator and excessive levels of low volatile fragrance materials for Compositions B, E, H, K and N on fidelity of the floral aromas attributable to the volatile fragrance materials. It is observed that the floral aromas is perceived initially but then drops quickly over time. Addition of the substantially non-odorous fragrance modulator does not result in improved fidelity of the floral aromas as seen in Compositions B, E, H, K and N. There are no statistical differences between the 2 products."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.6, "construct": {"method_text_verbatim": "The composition of any one of the preceding claims, wherein tthe composition maintains the perceived fragrance profile, particularly the aromas attributable to the moderate volatile fragrance material and/or high volatile fragrance material, to remain substantively unchanged from application up to 2 hrs, 3 hrs, 4 hrs, 5 hrs, 6 hrs or 8 hrs after application vs. a control composition that does not include a diamond construction fragrance formulation and the substantially non-odorous fragrance modulator, as determined according to the Odour Test as described herein.", "panel_size": null, "property_name": "substantivity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["2 hrs", "3 hrs", "4 hrs", "5 hrs", "6 hrs", "8 hrs"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "2 hrs; 3 hrs; 4 hrs; 5 hrs; 6 hrs; 8 hrs", "patent_id": "EP3103431A1", "provenance": {"citation": "EP3103431A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3103431A1/en"}, "pub_date": "2015-06-12", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "claims:15", "units": "hours", "verbatim_quote": "The composition of any one of the preceding claims, wherein tthe composition maintains the perceived fragrance profile, particularly the aromas attributable to the moderate volatile fragrance material and/or high volatile fragrance material, to remain substantively unchanged from application up to 2 hrs, 3 hrs, 4 hrs, 5 hrs, 6 hrs or 8 hrs after application vs. a control composition that does not include a diamond construction fragrance formulation and the substantially non-odorous fragrance modulator, as determined according to the Odour Test as described herein."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Procter and Gamble Co", "compound_ref_verbatim": null, "confidence": 0.85, "construct": {"method_text_verbatim": "The method of claim 17, wherein the method is preferably for imparting, intensifying or modifying the longevity of a floral aroma on human skin or human hair, wherein the perceived intensity of the floral aroma at 1 hr, 2 hrs, 3 hrs or 6 hrs after application is greater than a control composition that does not include the substantially non-odorous fragrance modulator as determined by the panel method as disclosed herein, and wherein the floral aroma is selected from the group consisting of lavender-type note, a rose-type note, a lily of the valley-type note, a muguet-type note, a jasmine-type note, a magnolia-type note, a cyclamen-type note, a hyacinth-type note, a lilac-type note, an orange blossom-type note, a cherry blossom-type note, a peony-type note, a lotus-type note, a linden blossom-type note, an osmanthus-type note, a lilac-type note, a heliotrope-type note, a violet-type note, an orris-type note, a tiare-type note, a patchouli-type note and the like.", "panel_size": null, "property_name": "longevity", "scale": "hours_or_timepoint", "substrate": ["hair", "skin"], "time_points": ["1 hr", "2 hrs", "3 hrs", "6 hrs"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "1 hr; 2 hrs; 3 hrs; 6 hrs", "patent_id": "EP3103431A1", "provenance": {"citation": "EP3103431A1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3103431A1/en"}, "pub_date": "2015-06-12", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "claims:18", "units": "hours", "verbatim_quote": "The method of claim 17, wherein the method is preferably for imparting, intensifying or modifying the longevity of a floral aroma on human skin or human hair, wherein the perceived intensity of the floral aroma at 1 hr, 2 hrs, 3 hrs or 6 hrs after application is greater than a control composition that does not include the substantially non-odorous fragrance modulator as determined by the panel method as disclosed herein, and wherein the floral aroma is selected from the group consisting of lavender-type note, a rose-type note, a lily of the valley-type note, a muguet-type note, a jasmine-type note, a magnolia-type note, a cyclamen-type note, a hyacinth-type note, a lilac-type note, an orange blossom-type note, a cherry blossom-type note, a peony-type note, a lotus-type note, a linden blossom-type note, an osmanthus-type note, a lilac-type note, a heliotrope-type note, a violet-type note, an orris-type note, a tiare-type note, a patchouli-type note and the like."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Coty Inc", "compound_ref_verbatim": null, "confidence": 0.6, "construct": {"method_text_verbatim": "Beyond extending the initial impression of the fragrance, the strength and longevity of the high volatile fragrances can be improved. For example, according to some embodiments, compositions having improved longevity of the perceived fragrance profile can be present for long periods of time (e.g., greater than 30 mins, 1, 2, 4, 6, or even 8 hours). The improved longevity of the high volatile fragrances may result from the modulator slowing the evaporation of the high and moderate volatile fragrances from the composition.", "panel_size": null, "property_name": "longevity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["8 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "8 hours", "patent_id": "EP3743163B1", "provenance": {"citation": "EP3743163B1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3743163B1/en"}, "pub_date": "2018-07-25", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:6", "units": "hours", "verbatim_quote": "Beyond extending the initial impression of the fragrance, the strength and longevity of the high volatile fragrances can be improved. For example, according to some embodiments, compositions having improved longevity of the perceived fragrance profile can be present for long periods of time (e.g., greater than 30 mins, 1, 2, 4, 6, or even 8 hours). The improved longevity of the high volatile fragrances may result from the modulator slowing the evaporation of the high and moderate volatile fragrances from the composition."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Coty Inc", "compound_ref_verbatim": null, "confidence": 0.7, "construct": {"method_text_verbatim": "At the testing facility, 50 \u00b5L samples of the compositions and the controls are applied to glass slides and placed on a hot plate at 32 \u00b0C to represent skin temperature for varying durations. It is important that glass slides of samples that are to be later compared are prepared at the same time. The panelists are asked to evaluate the perceived fragrance profile (intensity and/or character) of each glass slide sample at a given time point. Slides are presented coded so that their identity is not known by the panelists. Within a given time point panelists evaluate the slides in a random order and are able to revisit their assessment as they work through the slides at that time point. Their assessments are recorded. In the subsequent analysis, the data for strength and character comparisons are drawn from the independent assessments carried out at a given time point. Only when using the character difference scale below are any 2 products physically directly compared to each other. Panel", "panel_size": null, "property_name": "duration", "scale": "numeric_unknown", "substrate": ["skin"], "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "4-6", "patent_id": "EP3743163B1", "provenance": {"citation": "EP3743163B1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3743163B1/en"}, "pub_date": "2018-07-25", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:1078", "units": null, "verbatim_quote": "At the testing facility, 50 \u00b5L samples of the compositions and the controls are applied to glass slides and placed on a hot plate at 32 \u00b0C to represent skin temperature for varying durations. It is important that glass slides of samples that are to be later compared are prepared at the same time. The panelists are asked to evaluate the perceived fragrance profile (intensity and/or character) of each glass slide sample at a given time point. Slides are presented coded so that their identity is not known by the panelists. Within a given time point panelists evaluate the slides in a random order and are able to revisit their assessment as they work through the slides at that time point. Their assessments are recorded. In the subsequent analysis, the data for strength and character comparisons are drawn from the independent assessments carried out at a given time point. Only when using the character difference scale below are any 2 products physically directly compared to each other. Panelists are selected from individuals who are either trained to evaluate fragrances according to the scales below or who have experience of fragrance evaluation in the industry. Typically, around 4-6 expert panelists are used to evaluate a given product and its control."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Coty Inc", "compound_ref_verbatim": null, "confidence": 0.55, "construct": {"method_text_verbatim": "The panelists are asked to give a score on a scale of 0 to 5 for perceived fragrance intensity according to the odour intensity scale set out in Table 5 herein below. Table 5 - Odour Intensity Scale Score Fragrance Intensity 0 None 1 Very Weak 2 Weak 3 Moderate 4 Strong 5 Very Strong", "panel_size": null, "property_name": "fragrance_intensity", "scale": "numeric_unknown", "substrate": null, "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "0 to 5", "patent_id": "EP3743163B1", "provenance": {"citation": "EP3743163B1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3743163B1/en"}, "pub_date": "2018-07-25", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:1079", "units": null, "verbatim_quote": "The panelists are asked to give a score on a scale of 0 to 5 for perceived fragrance intensity according to the odour intensity scale set out in Table 5 herein below. Table 5 - Odour Intensity Scale Score Fragrance Intensity 0 None 1 Very Weak 2 Weak 3 Moderate 4 Strong 5 Very Strong"}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": "Coty Inc", "compound_ref_verbatim": "example 15", "confidence": 0.75, "construct": {"method_text_verbatim": "The following test is carried out to demonstrate the improved or enhanced longevity of a fragrance profile of a composition of the present invention vs. a control. In particular, the test measures the effect of a substantially non-odorous fragrance modulator on the evaporation rate of one or more fragrance materials formulated in a composition. The evaporation response of the fragrance materials to the modulator, as a function of time, is measured through the use of gas chromatography (\"GC\"). 1. A test composition may comprise a substantially non-odorous fragrance modulator (any one of the modulators as disclosed in Tables 4(a) and 4(b)) with either: (i) a fragrance material (any one of the moderate volatile fragrance materials as disclosed in Table 2 and 2a and high volatile fragrance materials as disclosed in Table 3 and 3a, or (ii) a blend of fragrance materials from Tables 1a, 1b, 2a, 2b, 3a and 3c (as disclosed as Fragrance Examples 1 to 6 ). The test compositions also contain eth", "panel_size": null, "property_name": "longevity", "scale": "percent", "substrate": null, "time_points": ["1 hr", "2 hrs", "3 hrs", "4 hrs", "5 hrs", "6 hrs", "8 hrs", "12 hrs", "180 minutes", "120 minutes", "60 minutes", "30 minutes", "15 minutes"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "1 to 6; 90 to 95; 1 hr; 2 hrs; 3 hrs; 4 hrs; 5 hrs; 6 hrs; 8 hrs; 12 hrs; 5 to 10; 25 to 40; 180 minutes; 120 minutes; 60 minutes; 30 minutes; 15 minutes", "patent_id": "EP3743163B1", "provenance": {"citation": "EP3743163B1", "retrieval_source": "Google Patents public page, used as Phase-0 convenience access; prefer official APIs/bulk for systematic retrieval", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3743163B1/en"}, "pub_date": "2018-07-25", "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description:1109", "units": "hours", "verbatim_quote": "The following test is carried out to demonstrate the improved or enhanced longevity of a fragrance profile of a composition of the present invention vs. a control. In particular, the test measures the effect of a substantially non-odorous fragrance modulator on the evaporation rate of one or more fragrance materials formulated in a composition. The evaporation response of the fragrance materials to the modulator, as a function of time, is measured through the use of gas chromatography (\"GC\"). 1. A test composition may comprise a substantially non-odorous fragrance modulator (any one of the modulators as disclosed in Tables 4(a) and 4(b)) with either: (i) a fragrance material (any one of the moderate volatile fragrance materials as disclosed in Table 2 and 2a and high volatile fragrance materials as disclosed in Table 3 and 3a, or (ii) a blend of fragrance materials from Tables 1a, 1b, 2a, 2b, 3a and 3c (as disclosed as Fragrance Examples 1 to 6 ). The test compositions also contain ethanol, and deionized water. Samples test compositions are provided in Tables 13, 14, 15 and 15 (d). All of the ingredients are admixed until evenly distributed in the test compositions. 2. A control composition to the test composition described in 1 above, without the substantially non-odorous fragrance modulator is made in a similar manner to Step 1, except that the missing substantially non-odorous modulator is replaced by deionized water. Sample control compositions are provided in Tables 13, 14, 15 and 15 (d) 3. An internal standard is needed to correct for variations of the amount of composition dispensed in the evaporation test as well as loss during the GC analysis. The internal standard has a vapor pressure of less than 0.001 Torr (0.000133 kPa) at 25 \u00b0C and is soluble in the composition and fragrance material. Alternatively the internal standard has a vapor pressure of less than 0.001 Torr (0.000133 kPa) at 25 \u00b0C and is soluble in ethanol or an ethanol/water solvent mixture to prepare an internal standard solution, which is then added to the fragrance material or composition. Suitable non-limiting examples of internal standards are triethyl citrate or denatonium benzoate. The internal standard and fragrance material, or blend of fragrance materials, are admixed until evenly distributed at a level of 90 to 95 parts by weight of fragrance material and the required amount of internal standard to reach 100 parts. This mixture is then used to prepare the sample compositions in Step 1 and 2. Alternatively, the internal standard is dissolved and diluted with ethanol or an ethanol/water mixture to obtain a solution. The internal standard solution and test or control composition are admixed until evenly distributed such that the resultant solution contains between 0.25 and 1.5% by weight of internal standard This resultant solution is used in subsequent steps. 4. A hotplate is set to a temperature of 32 \u00b0C. An aluminum container, such as TA Instruments T-Zero \u2122 pan, is placed on the hotplate. 20 \u00b5L of the test or control composition is introduced in the aluminum container using a micropipette. Alternatively, the aluminum container may be filled with the test or control composition to its full capacity. The time at which this takes place is determined to be time zero ( i.e., T = 0). Multiple aluminum containers are prepared and left at the set temperature for pre-determined periods of time, such as for example 15 mins, 30 mins, 1 hr, 2 hrs, 3 hrs, 4 hrs, 5 hrs, 6 hrs, 8 hrs and up to 12 hrs. 5. The aluminum container is removed from the hotplate at the end of the pre-determined time period and transferred by being inserted into a 4 mL glass vial already containing at least 2 mL of highly volatile solvent, such as high purity ethanol or hexane. 6. The glass vial is mixed using a Heidolph multi REAX shaker, or equivalent, for 5 to 10 mins to extract the fragrance materials into the solvent phase. 1 mL of the resultant solution is transferred to a 2 mL GC vial. 7. The GC vial is analysed on an Agilent GC system 6890 equipped with an autosampler, or equivalent. A GC column such as a DB-5MS, ZB-5 lMSi models or equivalent phase, with a length of 30 m, an inner diameter of 0.25 mm and a film thickness of 1 \u00b5m is used. The GC parameters are set to the values indicated as follows: Table 6(iii) - GC Parameters Injector temperature: 250 \u00b0C Initial gas velocity: 25 to 40 cm/sec (for Helium as the carrier gas) Initial oven temperature: 50 \u00b0C Temperature ramp: 7 \u00b0C/min Final oven temperature: 325 \u00b0C Gas chromatograp hy with flame ionization detection (\"FID\") or with mass spectrometry (\"MS\") can be used for the identification and quantification of fragrance material in the compositions. Either detection system can be used in conjunction with GC. The column dimensions as well as GC settings described in this method, such as injector temperature, carrier gas velocity, temperature ramp and final oven temperature can be adjusted to optimize the response of the fragrance material and internal standard being monitored. The detection system settings, such as FID gas flows and temperature or MS parameters, should be optimized by a trained analyst to enable the precise detection and quantification of the analytes of interest. 8. The peak area of the fragrance material and internal standard are recorded. The peak area ratio of the fragrance material and the internal standard is calculated at each time point for each sample composition. The % of non-evaporated fragrance material remaining from T = 0 is calculated at each time point for each sample composition. The % fragrance material remaining in each composition is plotted to give an evaporation profile over time. This is done for both the test and control compositions. Significance is determined by comparison of the evaporation profile for the same fragrance material or same fragrance mixture in the test and control compositions. In addition, the sum of peak areas for a group of fragrance materials, such as high or moderate volatile fragrance materials, is calculated and used to determine the percentage of such materials remaining in each composition. Unidentified peaks were excluded. From the generated data the decay of the high volatility fragrance materials were analyzed. To determine the error, tests were run in triplicate and an average of the % fragrance materials remaining and a standard deviation value were calculated. An example of data output is shown in Table 6(iv). The output shows the standard deviation at 180 minutes, 120 minutes, 60 minutes, 30 minutes, and 15 minutes. Modulators tested include iso cetyl alcohol (ICA), Glucam, and a reference product (REF). Table 6(iv): % remaining 180 120 60 30 15 ICA Average 2.09 3.14 5.06 10.63 22.34 ICA SD 0.50 0.90 0.90 0.52 1.54 REF Average 0.11 0.27 1.34 3.67 6.60 REF SD 0.03 0.07 0.07 0.22 1.74 Glucam average 1.37 2.22 4.11 6.91 13.07 Glucam SD 0.93 0.99 1.33 1.87 3.25"}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": null, "compound_ref_verbatim": null, "confidence": 0.45, "construct": {"method_text_verbatim": "The present invention relates to the field of perfumery. In particular, the compositions of the present invention have improved or enhanced fidelity and/or longevity of the fragrance profile, which is achieved by adding a specific sucrose based fragrance modulator as defined in the appended claims. Fragrance modulators do already exist, see e.g. [EP 1 186 289 A2](https://patents.google.com/patent/EP1186289A2) (TAKASAGO PERFUMERY CO LTD \\[JP\\]) 13 March 2002 (2002-03-13).", "panel_size": null, "property_name": "longevity", "scale": "numeric_unknown", "substrate": null, "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "2002-03", "patent_id": "EP3307393B1", "provenance": {"citation": "EP3307393B1", "retrieval_source": "Firecrawl scrape of Google Patents public page", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3307393B1/en"}, "pub_date": null, "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description_translated_from:204", "units": null, "verbatim_quote": "The present invention relates to the field of perfumery. In particular, the compositions of the present invention have improved or enhanced fidelity and/or longevity of the fragrance profile, which is achieved by adding a specific sucrose based fragrance modulator as defined in the appended claims. Fragrance modulators do already exist, see e.g. [EP 1 186 289 A2](https://patents.google.com/patent/EP1186289A2) (TAKASAGO PERFUMERY CO LTD \\[JP\\]) 13 March 2002 (2002-03-13)."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": null, "compound_ref_verbatim": null, "confidence": 0.6, "construct": {"method_text_verbatim": "Previous attempts to overcome these problems have been through the use of various \"fixatives\" or \"modulators\" to retard the evaporation of the more volatile fragrance ingredients present in fragrance compositions. For instance, [U.S. Patent No. 4,313,855](https://patents.google.com/patent/US4313855) (Dragoco) describes the use in cosmetic compositions of 1-(2,6,6-trimethylcyclohexyl)-hexane-3-ol as an odourless fixative for increasing the perfume's intensity. [U.S. Patent No. 6,147,049](https://patents.google.com/patent/US6147049) (Givaudan) discloses a perfume fixative derived from tera-hydronaphthalenese for use in a wide range of fragrance compositions. [U.S. Patent No. 6,440,400B1](https://patents.google.com/patent/US6440400) (Takasago Perfumery) describes a composition using trimethylcyclohexane derivatives as perfuming-holding agents and melanin-formation inhibitors. [U.S. Patent No. 6,737,396B2](https://patents.google.com/patent/US6737396) (Firmenich) describes a perfume composi", "panel_size": null, "property_name": "persistence", "scale": "percent", "substrate": ["skin"], "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "2-30; 61-083114; 61-063612; 62-084010; 2014/090959; 2003/228334", "patent_id": "EP3307393B1", "provenance": {"citation": "EP3307393B1", "retrieval_source": "Firecrawl scrape of Google Patents public page", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3307393B1/en"}, "pub_date": null, "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description_translated_from:213", "units": "ordinal_ratio", "verbatim_quote": "Previous attempts to overcome these problems have been through the use of various \"fixatives\" or \"modulators\" to retard the evaporation of the more volatile fragrance ingredients present in fragrance compositions. For instance, [U.S. Patent No. 4,313,855](https://patents.google.com/patent/US4313855) (Dragoco) describes the use in cosmetic compositions of 1-(2,6,6-trimethylcyclohexyl)-hexane-3-ol as an odourless fixative for increasing the perfume's intensity. [U.S. Patent No. 6,147,049](https://patents.google.com/patent/US6147049) (Givaudan) discloses a perfume fixative derived from tera-hydronaphthalenese for use in a wide range of fragrance compositions. [U.S. Patent No. 6,440,400B1](https://patents.google.com/patent/US6440400) (Takasago Perfumery) describes a composition using trimethylcyclohexane derivatives as perfuming-holding agents and melanin-formation inhibitors. [U.S. Patent No. 6,737,396B2](https://patents.google.com/patent/US6737396) (Firmenich) describes a perfume composition formed by mixing 2-30%, relative to the weight of the composition, of a fixative, (1-ethoxyethoxy)cyclododecane, to fix or exalt the musky or aromatic-type notes. [U.S. Patent No. 7,538,081](https://patents.google.com/patent/US7538081) (Takasago Perfumery) approaches the same problem of fixing a perfume and/or extending the perfume release from a fragrance composition. More particularly, said document describes the use of L-menthoxy ether derivatives as fixatives in fragrance compositions comprising at least one note selected from: floral, citrus, fruity, green, mint, herb and marine. JP Patent No. 61-083114 (Kanebo) describes ether derivatives as aroma-preserving agent for fine perfume composition. JP Patent No. 61-063612 (Kanebo) discloses diethylene glycol ether derivatives as fragrance adjusting agent showing effects as a fixative and a solubilizer. JP Patent No. 62-084010 (Shiseido) describes hydroquinone glycoside as perfume fixatives applicable for all kinds of perfume and blended perfume. On the other hand, PCT Publication No. WO85/04803 (Diagnostica) describes the use of hyaluronic acid/ hyaluronate as fixatives ( _via_ molecular encapsulation) in fragrance products to improve persistence of the fragrance. EP 1 186 289 describes fragrance compositions having excellent diffusivity and a long-lasting effect by incorporating a novel fixative in the composition, wherein the fixative is a 2-(L-menthoxy)alkanol derivative. EP 1 103 250 describes oil-in-polyhydric-alcohol type warming base agents containing a polyhydric alcohol, a sucrose fatty acid ester and an oil, having superior makeup removal effect, safety, stability and warming sensation. [WO 2014/090959](https://patents.google.com/patent/WO2014090959) discloses perfuming compositions that are free of ethanol in the form of transparent, clear microemulsions containing a fragrance, a solvent, non-ionic and ionic surfactants, a cooling hydrotrope and water. [US 2003/228334](https://patents.google.com/patent/US20030228334) relates to oil-in-water emulsions having a mattifying effect on the skin. The emulsions comprise a hydrophilic, non-organically modified magnesium aluminum silicate or a bentonite clay and a polyol in the water phase; and a volatile lipophilic solvent and a high melting point lipophilic plasticizer in the oil phase; and a surfactant system incuding non-toxic metal alkyl sulfates and/or sucrose esters. [DE 197 18 777](https://patents.google.com/patent/DE19718777) discloses the use of one or more di- or oligo-saccharide fatty acid esters as anti-adhesive agents against microorganisms, viruses, parasites and protozoa."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": null, "compound_ref_verbatim": null, "confidence": 0.45, "construct": {"method_text_verbatim": "The inventors have surprisingly discovered a revolutionary new way of objectively classifying fragrance materials and then formulating those fragrance materials into complex fragrance mixtures having improved fragrance profile fidelity and longevity. Essentially, the solution is to formulate the fragrance materials having low levels (10 to 30 wt% relative to the total weight of the fragrance materials) of the low volatile fragrance materials in the presence of a substantially non-odorous fragrance modulator to provide for improved or enhanced longevity and/or fidelity of the fragrance profile, particularly amongst characters attributable to volatile fragrance materials. In fact, the inventors have discovered that in the complete absence of the low volatile fragrance materials or at very low levels of the low volatile fragrance materials (less than 10 wt% relative to the total weight of the fragrance materials), there is insufficient character complexity and roundness of the fragrance p", "panel_size": null, "property_name": "longevity", "scale": "percent", "substrate": null, "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "10 to 30", "patent_id": "EP3307393B1", "provenance": {"citation": "EP3307393B1", "retrieval_source": "Firecrawl scrape of Google Patents public page", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3307393B1/en"}, "pub_date": null, "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description_translated_from:240", "units": null, "verbatim_quote": "The inventors have surprisingly discovered a revolutionary new way of objectively classifying fragrance materials and then formulating those fragrance materials into complex fragrance mixtures having improved fragrance profile fidelity and longevity. Essentially, the solution is to formulate the fragrance materials having low levels (10 to 30 wt% relative to the total weight of the fragrance materials) of the low volatile fragrance materials in the presence of a substantially non-odorous fragrance modulator to provide for improved or enhanced longevity and/or fidelity of the fragrance profile, particularly amongst characters attributable to volatile fragrance materials. In fact, the inventors have discovered that in the complete absence of the low volatile fragrance materials or at very low levels of the low volatile fragrance materials (less than 10 wt% relative to the total weight of the fragrance materials), there is insufficient character complexity and roundness of the fragrance profile for consumer acceptance of the composition. Therefore the level of low volatile fragrance materials needs to be carefully chosen between 10 and 30 wt% to balance consumer acceptance and the desired improved or enhanced longevity and/or fidelity of the fragrance profile, particularly amongst characters attributable to volatile fragrance materials."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": null, "compound_ref_verbatim": null, "confidence": 0.7, "construct": {"method_text_verbatim": "At the testing facility, 50 \u00b5L samples of the compositions and the controls are applied to glass slides and placed on a hot plate at 32 \u00b0C to represent skin temperature for varying durations. It is important that glass slides of samples that are to be later compared are prepared at the same time. The panelists are asked to evaluate the perceived fragrance profile (intensity and/or character) of each glass slide sample at a given time point. Slides are presented coded so that their identity is not known by the panelists. Within a given time point panelists evaluate the slides in a random order and are able to revisit their assessment as they work through the slides at that time point. Their assessments are recorded. In the subsequent analysis, the data for strength and character comparisons are drawn from the independent assessments carried out at a given time point. Only when using the character difference scale below are any 2 products physically directly compared to each other. Panel", "panel_size": null, "property_name": "duration", "scale": "numeric_unknown", "substrate": ["skin"], "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "6 to 10", "patent_id": "EP3307393B1", "provenance": {"citation": "EP3307393B1", "retrieval_source": "Firecrawl scrape of Google Patents public page", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3307393B1/en"}, "pub_date": null, "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description_translated_from:336", "units": null, "verbatim_quote": "At the testing facility, 50 \u00b5L samples of the compositions and the controls are applied to glass slides and placed on a hot plate at 32 \u00b0C to represent skin temperature for varying durations. It is important that glass slides of samples that are to be later compared are prepared at the same time. The panelists are asked to evaluate the perceived fragrance profile (intensity and/or character) of each glass slide sample at a given time point. Slides are presented coded so that their identity is not known by the panelists. Within a given time point panelists evaluate the slides in a random order and are able to revisit their assessment as they work through the slides at that time point. Their assessments are recorded. In the subsequent analysis, the data for strength and character comparisons are drawn from the independent assessments carried out at a given time point. Only when using the character difference scale below are any 2 products physically directly compared to each other. Panelists are selected from individuals who are either trained to evaluate fragrances according to the scales below or who have experience with fragrance evaluation in the industry. Typically, around 6 to 10 panellists are used to evaluate a given product and its control."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": null, "compound_ref_verbatim": null, "confidence": 0.55, "construct": {"method_text_verbatim": "The panelists are asked to give a score on a scale of 0 to 5 for perceived fragrance intensity according to the odour intensity scale set out in Table 4 herein below. Table 4 - Odour Intensity Scale", "panel_size": null, "property_name": "fragrance_intensity", "scale": "numeric_unknown", "substrate": null, "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "0 to 5", "patent_id": "EP3307393B1", "provenance": {"citation": "EP3307393B1", "retrieval_source": "Firecrawl scrape of Google Patents public page", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3307393B1/en"}, "pub_date": null, "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description_translated_from:338", "units": null, "verbatim_quote": "The panelists are asked to give a score on a scale of 0 to 5 for perceived fragrance intensity according to the odour intensity scale set out in Table 4 herein below. Table 4 - Odour Intensity Scale"}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": null, "compound_ref_verbatim": "example 10", "confidence": 0.9, "construct": {"method_text_verbatim": "5\\. Multiple glass capillaries are prepared in the same way and left to evaporate at ambient temperature for pre-determined periods of time, such as for example 10, 15, 30 mins, 1 hr, 2 hrs, 3 hrs, 4 hrs, 5 hrs, and up to 6 hrs, before being introduced to the headspace vial and sealed.", "panel_size": null, "property_name": "headspace_concentration_or_intensity", "scale": "hours_or_timepoint", "substrate": ["headspace"], "time_points": ["1 hr", "2 hrs", "3 hrs", "4 hrs", "5 hrs", "6 hrs"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "1 hr; 2 hrs; 3 hrs; 4 hrs; 5 hrs; 6 hrs", "patent_id": "EP3307393B1", "provenance": {"citation": "EP3307393B1", "retrieval_source": "Firecrawl scrape of Google Patents public page", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3307393B1/en"}, "pub_date": null, "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description_translated_from:366", "units": "hours", "verbatim_quote": "5\\. Multiple glass capillaries are prepared in the same way and left to evaporate at ambient temperature for pre-determined periods of time, such as for example 10, 15, 30 mins, 1 hr, 2 hrs, 3 hrs, 4 hrs, 5 hrs, and up to 6 hrs, before being introduced to the headspace vial and sealed."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": null, "compound_ref_verbatim": null, "confidence": 0.7, "construct": {"method_text_verbatim": "Compositions disclosed in Tables 18(a) and 19(a)-19(b) are applied to glass slides in accordance with the protocol described in the Method Section and a panel of around 6-10 experienced panelists evaluate the perceived fragrance profile at initial time 0, then at various time points, typically 1 hour, 2 hours, 3 hours, 4 hours and 6 hours post application. Panelists are asked to score the compositions for the longevity of the fragrance profile on a scale of 0 to 5, wherein 0 represents a no fragrance is detected and 5 represents a very strong fragrance intensity is detected; and for fragrance profile fidelity on a scale of 0 to 3 wherein 0 represents not detectable and 3 represents it being the dominant character. The results of the panelists are then averaged and discussed below.", "panel_size": null, "property_name": "fragrance_intensity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["1 hour", "2 hours", "3 hours", "4 hours", "6 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "6-10; 1 hour; 2 hours; 3 hours; 4 hours; 6 hours; 0 to 5; 0 to 3", "patent_id": "EP3307393B1", "provenance": {"citation": "EP3307393B1", "retrieval_source": "Firecrawl scrape of Google Patents public page", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3307393B1/en"}, "pub_date": null, "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description_translated_from:440", "units": "hours", "verbatim_quote": "Compositions disclosed in Tables 18(a) and 19(a)-19(b) are applied to glass slides in accordance with the protocol described in the Method Section and a panel of around 6-10 experienced panelists evaluate the perceived fragrance profile at initial time 0, then at various time points, typically 1 hour, 2 hours, 3 hours, 4 hours and 6 hours post application. Panelists are asked to score the compositions for the longevity of the fragrance profile on a scale of 0 to 5, wherein 0 represents a no fragrance is detected and 5 represents a very strong fragrance intensity is detected; and for fragrance profile fidelity on a scale of 0 to 3 wherein 0 represents not detectable and 3 represents it being the dominant character. The results of the panelists are then averaged and discussed below."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": null, "compound_ref_verbatim": null, "confidence": 0.7, "construct": {"method_text_verbatim": "Figure 1 shows the fragrance intensity profile of Composition R as evaluated by 10 panelists, which comprises the substantially non-odorous fragrance modulator sucrose myristate and the single fragrance material, ethyl safranate. Addition of the substantially non-odorous fragrance modulator maintains the intensity of the fragrance material for up to 6 hours whilst the control, Composition S, in the absence of the substantially non-odorous fragrance modulator, drops in fragrance intensity profile over the 6 hours. The substantially non-odorous fragrance modulator acts to maintain the continued evaporation over time of the fragrance material. Statistical analysis using the Tukey correction for multiple comparisons confirms the statistically significant difference at 0 hours (p = 0.0015), 1hour (p = 0.0033), 3hours (p = 0.0015) and 6 hours ((p = 0.0152) all at 95% significance level ( _i.e.,_ p < 0.05).", "panel_size": 10, "property_name": "fragrance_intensity", "scale": "percent", "substrate": null, "time_points": ["6 hours", "0 hours", "1hour", "3hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "6 hours; 0 hours; 1hour; 3hours", "patent_id": "EP3307393B1", "provenance": {"citation": "EP3307393B1", "retrieval_source": "Firecrawl scrape of Google Patents public page", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3307393B1/en"}, "pub_date": null, "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description_translated_from:442", "units": "hours", "verbatim_quote": "Figure 1 shows the fragrance intensity profile of Composition R as evaluated by 10 panelists, which comprises the substantially non-odorous fragrance modulator sucrose myristate and the single fragrance material, ethyl safranate. Addition of the substantially non-odorous fragrance modulator maintains the intensity of the fragrance material for up to 6 hours whilst the control, Composition S, in the absence of the substantially non-odorous fragrance modulator, drops in fragrance intensity profile over the 6 hours. The substantially non-odorous fragrance modulator acts to maintain the continued evaporation over time of the fragrance material. Statistical analysis using the Tukey correction for multiple comparisons confirms the statistically significant difference at 0 hours (p = 0.0015), 1hour (p = 0.0033), 3hours (p = 0.0015) and 6 hours ((p = 0.0152) all at 95% significance level ( _i.e.,_ p < 0.05)."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": null, "compound_ref_verbatim": null, "confidence": 0.7, "construct": {"method_text_verbatim": "Figure 2 shows the fragrance intensity profile of Composition P as evaluated by 10 panellists, which comprises the substantially non-odorous fragrance modulator sucrose myristate and the single fragrance material, Dimethylbenzyl carbinol. Addition of the substantially non-odorous fragrance modulator maintains the intensity of the fragrance material for up to 6 hours whilst the control, Composition Q, in the absence of the substantially non-odorous fragrance modulator, drops in fragrance intensity profile over the 6 hours. The substantially non-odorous fragrance modulator acts to maintain the continued evaporation over time of the fragrance material. Statistical analysis using the Tukey correction for multiple comparisons confirms the statistically significant difference at 1hour (p = 0.0581) at 90% significance level ( _i.e.,_ p < 0.1), 3hours (p = 0.0311) at 95% significance level ( _i.e.,_ p < 0.05).", "panel_size": null, "property_name": "fragrance_intensity", "scale": "percent", "substrate": null, "time_points": ["6 hours", "1hour", "3hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "6 hours; 1hour; 3hours", "patent_id": "EP3307393B1", "provenance": {"citation": "EP3307393B1", "retrieval_source": "Firecrawl scrape of Google Patents public page", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3307393B1/en"}, "pub_date": null, "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description_translated_from:443", "units": "hours", "verbatim_quote": "Figure 2 shows the fragrance intensity profile of Composition P as evaluated by 10 panellists, which comprises the substantially non-odorous fragrance modulator sucrose myristate and the single fragrance material, Dimethylbenzyl carbinol. Addition of the substantially non-odorous fragrance modulator maintains the intensity of the fragrance material for up to 6 hours whilst the control, Composition Q, in the absence of the substantially non-odorous fragrance modulator, drops in fragrance intensity profile over the 6 hours. The substantially non-odorous fragrance modulator acts to maintain the continued evaporation over time of the fragrance material. Statistical analysis using the Tukey correction for multiple comparisons confirms the statistically significant difference at 1hour (p = 0.0581) at 90% significance level ( _i.e.,_ p < 0.1), 3hours (p = 0.0311) at 95% significance level ( _i.e.,_ p < 0.05)."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": null, "compound_ref_verbatim": null, "confidence": 0.7, "construct": {"method_text_verbatim": "Figure 3 shows the fragrance intensity profile of Composition T as evaluated by 10 panelists, which comprises the substantially non-odorous fragrance modulator sucrose myristate and the single fragrance material phenethyl alcohol (PEA). Addition of the substantially non-odorous fragrance modulator maintains the intensity of the fragrance material for up to 6 hours whilst the control, Composition U, in the absence of the substantially non-odorous fragrance modulator, drops in fragrance intensity profile over the 6 hours. The substantially non-odorous fragrance modulator acts to maintain the continued evaporation over time of the fragrance material. Statistical analysis using the Tukey correction for multiple comparisons confirms the statistically significant difference at 1 hour (p < 0.0001), 3 hours (p = 0.0016) and 6 hours (p= 0.0003) all at 95% significance level ( _i.e.,_ p < 0.05).", "panel_size": 10, "property_name": "fragrance_intensity", "scale": "percent", "substrate": null, "time_points": ["6 hours", "1 hour", "3 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "6 hours; 1 hour; 3 hours", "patent_id": "EP3307393B1", "provenance": {"citation": "EP3307393B1", "retrieval_source": "Firecrawl scrape of Google Patents public page", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3307393B1/en"}, "pub_date": null, "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description_translated_from:444", "units": "hours", "verbatim_quote": "Figure 3 shows the fragrance intensity profile of Composition T as evaluated by 10 panelists, which comprises the substantially non-odorous fragrance modulator sucrose myristate and the single fragrance material phenethyl alcohol (PEA). Addition of the substantially non-odorous fragrance modulator maintains the intensity of the fragrance material for up to 6 hours whilst the control, Composition U, in the absence of the substantially non-odorous fragrance modulator, drops in fragrance intensity profile over the 6 hours. The substantially non-odorous fragrance modulator acts to maintain the continued evaporation over time of the fragrance material. Statistical analysis using the Tukey correction for multiple comparisons confirms the statistically significant difference at 1 hour (p < 0.0001), 3 hours (p = 0.0016) and 6 hours (p= 0.0003) all at 95% significance level ( _i.e.,_ p < 0.05)."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": null, "compound_ref_verbatim": null, "confidence": 0.7, "construct": {"method_text_verbatim": "Figure 4 shows the fragrance intensity profile of Composition ZZ as evaluated by 11 panelists, which comprises the substantially non-odorous fragrance modulator hydroquinone beta-D-glycoside and the single fragrance material, eugenol. Addition of the substantially non-odorous modulator maintains the intensity of the fragrance material for up to 6 hours whilst the control, Composition ZZZ, in the absence of the substantially non-odorous fragrance modulator, drops in fragrance intensity profile over the 6 hours. The substantially non-odorous fragrance modulator acts to maintain the continued evaporation over time of the fragrance material. Statistical analysis using the Tukey correction for multiple comparisons confirms the statistically significant difference at 1 hour (p = 0.0008) and 3 hours (p = 0.0123) all at 95% significance level ( _i.e.,_ p < 0.05).", "panel_size": 11, "property_name": "fragrance_intensity", "scale": "percent", "substrate": null, "time_points": ["6 hours", "1 hour", "3 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "6 hours; 1 hour; 3 hours", "patent_id": "EP3307393B1", "provenance": {"citation": "EP3307393B1", "retrieval_source": "Firecrawl scrape of Google Patents public page", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3307393B1/en"}, "pub_date": null, "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description_translated_from:445", "units": "hours", "verbatim_quote": "Figure 4 shows the fragrance intensity profile of Composition ZZ as evaluated by 11 panelists, which comprises the substantially non-odorous fragrance modulator hydroquinone beta-D-glycoside and the single fragrance material, eugenol. Addition of the substantially non-odorous modulator maintains the intensity of the fragrance material for up to 6 hours whilst the control, Composition ZZZ, in the absence of the substantially non-odorous fragrance modulator, drops in fragrance intensity profile over the 6 hours. The substantially non-odorous fragrance modulator acts to maintain the continued evaporation over time of the fragrance material. Statistical analysis using the Tukey correction for multiple comparisons confirms the statistically significant difference at 1 hour (p = 0.0008) and 3 hours (p = 0.0123) all at 95% significance level ( _i.e.,_ p < 0.05)."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": null, "compound_ref_verbatim": null, "confidence": 0.45, "construct": {"method_text_verbatim": "(b) Effects of the Substantially Non-Odorous Fragrance Modulators on the Fragrance Profile Longevity of Compositions having Reduced Levels of Low Volatile Fragrance Materials (between 10 to 30 wt% relative to the total weight of the Fragrance Materials) vs. Compositions having Traditional Levels of Low Volatile Fragrance Materials (Greater than 30 wt% relative to the total weight of the Fragrance Materials) and No Substantially Non-Odorous Fragrance Modulator- \\[0119\\]", "panel_size": null, "property_name": "longevity", "scale": "percent", "substrate": null, "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "10 to 30", "patent_id": "EP3307393B1", "provenance": {"citation": "EP3307393B1", "retrieval_source": "Firecrawl scrape of Google Patents public page", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3307393B1/en"}, "pub_date": null, "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description_translated_from:446", "units": null, "verbatim_quote": "(b) Effects of the Substantially Non-Odorous Fragrance Modulators on the Fragrance Profile Longevity of Compositions having Reduced Levels of Low Volatile Fragrance Materials (between 10 to 30 wt% relative to the total weight of the Fragrance Materials) vs. Compositions having Traditional Levels of Low Volatile Fragrance Materials (Greater than 30 wt% relative to the total weight of the Fragrance Materials) and No Substantially Non-Odorous Fragrance Modulator- \\[0119\\]"}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": null, "compound_ref_verbatim": null, "confidence": 0.55, "construct": {"method_text_verbatim": "Panelists are asked to score the compositions for the intensity of the fragrance on a scale of 0 to 5, wherein 0 represents no fragrance intensity is detected and 5 represents a very strong fragrance intensity is detected. The results of the panel test are then averaged. The results show the effect of the substantially non-odorous fragrance modulator and reduced levels of low volatile fragrance materials for any one of the inventive Compositions A, D, G, J and M on fragrance profile longevity versus control Compositions C, F, I, L and O in the absence of a substantially non-odorous modulator. Alternatively, the results show the effect of the substantially non-odorous fragrance modulator and reduced levels of low volatile fragrance materials for any one of the inventive Compositions A, D, G, J and M on fragrance profile longevity versus traditional Compositions B, E, H, K and N in the presence of the substantially non-odorous fragrance modulator.", "panel_size": null, "property_name": "fragrance_intensity", "scale": "hours_or_timepoint", "substrate": null, "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "0 to 5", "patent_id": "EP3307393B1", "provenance": {"citation": "EP3307393B1", "retrieval_source": "Firecrawl scrape of Google Patents public page", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3307393B1/en"}, "pub_date": null, "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description_translated_from:447", "units": null, "verbatim_quote": "Panelists are asked to score the compositions for the intensity of the fragrance on a scale of 0 to 5, wherein 0 represents no fragrance intensity is detected and 5 represents a very strong fragrance intensity is detected. The results of the panel test are then averaged. The results show the effect of the substantially non-odorous fragrance modulator and reduced levels of low volatile fragrance materials for any one of the inventive Compositions A, D, G, J and M on fragrance profile longevity versus control Compositions C, F, I, L and O in the absence of a substantially non-odorous modulator. Alternatively, the results show the effect of the substantially non-odorous fragrance modulator and reduced levels of low volatile fragrance materials for any one of the inventive Compositions A, D, G, J and M on fragrance profile longevity versus traditional Compositions B, E, H, K and N in the presence of the substantially non-odorous fragrance modulator."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": null, "compound_ref_verbatim": null, "confidence": 0.6, "construct": {"method_text_verbatim": "Fragrance profile longevity, is maintained for up to at least 6 hours in the presence of the substantially non-odorous fragrance modulator whilst it drops in the absence of the substantially non-odorous fragrance modulator (data not shown). Without wishing to be bound by theory, it is believed that the substantially non-odorous fragrance modulator acts to maintain the continued evaporation over time of the fragrance materials, particular the volatile fragrance materials. The effect of the improved fragrance profile longevity of the present invention are noticeable at 1, 3 and 6 hours.", "panel_size": null, "property_name": "longevity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["6 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "6 hours", "patent_id": "EP3307393B1", "provenance": {"citation": "EP3307393B1", "retrieval_source": "Firecrawl scrape of Google Patents public page", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3307393B1/en"}, "pub_date": null, "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description_translated_from:448", "units": "hours", "verbatim_quote": "Fragrance profile longevity, is maintained for up to at least 6 hours in the presence of the substantially non-odorous fragrance modulator whilst it drops in the absence of the substantially non-odorous fragrance modulator (data not shown). Without wishing to be bound by theory, it is believed that the substantially non-odorous fragrance modulator acts to maintain the continued evaporation over time of the fragrance materials, particular the volatile fragrance materials. The effect of the improved fragrance profile longevity of the present invention are noticeable at 1, 3 and 6 hours."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": null, "compound_ref_verbatim": null, "confidence": 0.6, "construct": {"method_text_verbatim": "The test demonstrates the character retention over time of a fragrance composition. The results show the effect of the substantially non-odorous fragrance modulator and reduced levels of low volatile fragrance materials for any one of the inventive Compositions A, D, G, J, and M on fragrance profile longevity versus control Compositions C, F, I, L, and O, in the absence of the substantially non-odorous modulator. Alternatively, results show the effect of the substantially non-odorous fragrance modulator and reduced levels of low volatile fragrance materials for any one of the inventive Compositions A, D, G, J, and M on fragrance profile longevity versus traditional Compositions B, E, H, K, and N, in the presence of the substantially non-odorous fragrance modulator. Fragrance profile fidelity, particularly characters attributable to the volatile fragrance materials are maintained for up to at least 1 hour in the presence of the substantially non-odorous fragrance modulator whilst they d", "panel_size": null, "property_name": "longevity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["1 hour"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "1 hour", "patent_id": "EP3307393B1", "provenance": {"citation": "EP3307393B1", "retrieval_source": "Firecrawl scrape of Google Patents public page", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3307393B1/en"}, "pub_date": null, "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description_translated_from:464", "units": "hours", "verbatim_quote": "The test demonstrates the character retention over time of a fragrance composition. The results show the effect of the substantially non-odorous fragrance modulator and reduced levels of low volatile fragrance materials for any one of the inventive Compositions A, D, G, J, and M on fragrance profile longevity versus control Compositions C, F, I, L, and O, in the absence of the substantially non-odorous modulator. Alternatively, results show the effect of the substantially non-odorous fragrance modulator and reduced levels of low volatile fragrance materials for any one of the inventive Compositions A, D, G, J, and M on fragrance profile longevity versus traditional Compositions B, E, H, K, and N, in the presence of the substantially non-odorous fragrance modulator. Fragrance profile fidelity, particularly characters attributable to the volatile fragrance materials are maintained for up to at least 1 hour in the presence of the substantially non-odorous fragrance modulator whilst they drop in the absence of the substantially non-odorous fragrance modulator."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": null, "compound_ref_verbatim": null, "confidence": 0.45, "construct": {"method_text_verbatim": "17. A method to enhance the fragrance profile of a composition, preferably improve the longevity of a character, preferably a floral character, of a composition, comprising bringing into contact or mixing at least one substantially non-odorous fragrance modulator with at least one low volatile fragrance material according to a composition as defined according to any one of claims 1-16.", "panel_size": null, "property_name": "longevity", "scale": "numeric_unknown", "substrate": null, "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "1-16", "patent_id": "EP3307393B1", "provenance": {"citation": "EP3307393B1", "retrieval_source": "Firecrawl scrape of Google Patents public page", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP3307393B1/en"}, "pub_date": null, "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "claims_(19)_hide_dependent_translated_fr:505", "units": null, "verbatim_quote": "17. A method to enhance the fragrance profile of a composition, preferably improve the longevity of a character, preferably a floral character, of a composition, comprising bringing into contact or mixing at least one substantially non-odorous fragrance modulator with at least one low volatile fragrance material according to a composition as defined according to any one of claims 1-16."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": null, "compound_ref_verbatim": "Example 150", "confidence": 0.9, "construct": {"method_text_verbatim": "Bei einer Dosierung von 0.3 Gew.- % des Parf\u00fcm\u00f6ls F1 bzw. F2 im Allzweckreiniger ergibt sich folgender Befund: der Anteil von 3-\\[(4R)-4-Isopropylcyclohexen-1-yl)propanal bewirkt in dem das Parf\u00fcm\u00f6l F2 enthaltenden Allzweckreiniger eine Verst\u00e4rkung der blumigen Note gegen\u00fcber dem Allzweckreiniger, der das Parf\u00fcm\u00f6l F1 (ohne 3-\\[(4R)-4-Isopropylcyclohexen-1-yl\\]propanal) enth\u00e4lt. Ferner erscheint die Komposition des Allzweckreinigers mit dem Parf\u00fcm\u00f6l F2 viel cremiger und frischer als die des Allzweckreinigers mit dem Parf\u00fcm\u00f6l F1.At a dosage of 0.3% by weight of the perfume oil F1 or F2 in the all-purpose cleaner, the following result is obtained: the proportion of 3 - \\[(4R) -4-isopropylcyclohexen-1-yl) propanal causes in the perfume oil F2-containing all-purpose cleaner a Reinforcing the floral note over the all-purpose cleaner containing perfume oil F1 (without 3 - \\[(4R) -4-isopropylcyclohexen-1-yl\\] propanal). Furthermore, the composition of the all-purpose cleaner appears with the p", "panel_size": null, "property_name": "odor_intensity", "scale": "percent", "substrate": ["fabric", "hair", "skin"], "time_points": ["1 Minute", "1 minute", "2 minutes", "20 minutes", "2H", "1 hour", "0 days", "1 day", "2 days", "3 days", "4 days", "7 days", "8 days", "9 days"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "10%; 1 Minute; 1-2; 1 minute; 90-0; 20 minutes; 96 %; 96%; 2H; 2-5; 35-40; 4 to 8; 10 %; 1 hour; 0 days; 1 day; 2 days; 3 days; 4 days; 7 days; 8 days; 9 days; 4 to 7; 7 to 9; 0.01 to 99.99; 0.1 to 99.9; 0.5 to 99.5; 1.0 to 99.0; 1.5 to 98.5; 2.0 to 98.0; 0001 to 40; 001 to 25; 6 to 8; 0001 to 5; 001 to 2; 6 to 9; 1 to 10", "patent_id": "EP2578671B1", "provenance": {"citation": "EP2578671B1", "retrieval_source": "Firecrawl scrape of Google Patents public page", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/EP2578671B1/en"}, "pub_date": null, "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description_translated_from_german:447", "units": "hours", "verbatim_quote": "Bei einer Dosierung von 0.3 Gew.- % des Parf\u00fcm\u00f6ls F1 bzw. F2 im Allzweckreiniger ergibt sich folgender Befund: der Anteil von 3-\\[(4R)-4-Isopropylcyclohexen-1-yl)propanal bewirkt in dem das Parf\u00fcm\u00f6l F2 enthaltenden Allzweckreiniger eine Verst\u00e4rkung der blumigen Note gegen\u00fcber dem Allzweckreiniger, der das Parf\u00fcm\u00f6l F1 (ohne 3-\\[(4R)-4-Isopropylcyclohexen-1-yl\\]propanal) enth\u00e4lt. Ferner erscheint die Komposition des Allzweckreinigers mit dem Parf\u00fcm\u00f6l F2 viel cremiger und frischer als die des Allzweckreinigers mit dem Parf\u00fcm\u00f6l F1.At a dosage of 0.3% by weight of the perfume oil F1 or F2 in the all-purpose cleaner, the following result is obtained: the proportion of 3 - \\[(4R) -4-isopropylcyclohexen-1-yl) propanal causes in the perfume oil F2-containing all-purpose cleaner a Reinforcing the floral note over the all-purpose cleaner containing perfume oil F1 (without 3 - \\[(4R) -4-isopropylcyclohexen-1-yl\\] propanal). Furthermore, the composition of the all-purpose cleaner appears with the perfume oil F2 much creamier and fresher than the all-purpose cleaner with the perfume oil F1.\\ \\ **BEISPIEL 15AEXAMPLE 15A**Shampoo (Mengenangaben als Gew.-%)Shampoo (amounts in% by weight)\\ \\ **Materialmaterial****HerstellerManufacturer****INCI-NameINCI name****Anteilproportion of**Entionisiertes WasserDeionized waterWaterWater71,571.5Plantacare PS 10Plantacare PS 10Cognis Deutschland GmbHCognis Germany GmbHSodium Laureth Sulfate, Lauryl GlucosideSodium Laureth Sulfate, Lauryl Glucoside20,020.0Euperlan PK 771Euperlan PK 771Cognis Deutschland GmbHCognis Germany GmbHGlycol Distearate, Sodium Lauryl Sulfate, Cocamide MEA, Laureth-1 0Glycol Distearate, Sodium Lauryl Sulfate, Cocamide MEA, Laureth-1 06,06.0Dragocid LiquidDragocid LiquidSymriseSymrisePhenoxyethanol, Methylparaben, Ethylparaben, Butylparaben, Propylparaben, IsobutylparabenPhenoxyethanol, methylparaben, ethylparaben, butylparaben, propylparaben, isobutylparaben0,50.5Natrium ChloridSodium chlorideSodium ChlorideSodium Chloride1,41.4Citronens\u00e4ure Monohydrat kristallinCitric acid monohydrate crystallineCitric AcidCitric Acid0,10.1Parfum\u00f6l G1 bzw. G2Perfume oil G1 or G2SymriseSymriseParfum (Fragrance)Perfume (fragrance)0,50.5\\ \\ **BEISPIEL 15BEXAMPLE 15B**Zusammensetzung des Parf\u00fcm\u00f6ls G1 bzw. G2 (Mengenangaben als Gew.-%)Composition of the perfume oil G1 or G2 (amounts in% by weight)\\ \\ **RIECHSTOFFEfragrances****Parf\u00fcm\u00f6l G1 (Vergleich)Perfume oil G1 (comparison)****Parf\u00fcm\u00f6l G2 (Erfindungsgem\u00e4\u00df)Perfume oil G2 (according to the invention)**FARENAL(R)FARENAL (R)3,03.03,03.0FLORAZONFLORAZON0,50.50,50.5HEXENYL ACETATE CIS-3HEXENYL ACETATE CIS-33,03.03,03.0VERTOCITRALVERTOCITRAL1,01.01,01.0DYNASCONE 10 % DPGDYNASCONE 10% DPG2,02.02,02.0CYCLOGALBANAT(R)Cyclogalbanate (R)2,02.02,02.0STYRALYL ACETATESTYRALYL ACETATE1,51.51,51.5DIHYDRO MYRCENOLDIHYDRO MYRCENOL6,06.06,06.0OXANTHIA 50 % IN TEC 10 % DPGOXANTHIA 50% IN TEC 10% DPG10,010.010,010.0LEMON OIL ITAL.LEMON OIL ITAL.10,010.010,010.0ORANGE OIL BRASILORANGE OIL BRASIL50,050.050,050.0HEXYL ACETATEHEXYL ACETATE2,02.02,02.0ISOAMYL ACETATEISOAMYL ACETATE0,50.50,50.5PRENYLACETATEPRENYLACETATE0,50.50,50.5ETHYL BUTYRATE 10 % DPGETHYL BUTYRATE 10% DPG2,02.02,02.0ALDEHYDE C14 SO-CALLEDALDEHYDE C14 SO-CALLED25,025.025,025.0DECALACTONE GAMMADECALACTONE GAMMA5,05.05,05.0ETHYL METHYL BUTYRATE-2ETHYL METHYL BUTYRATE-21,01.01,01.0ALLYL CAPROATEALLYL CAPROATE1,51.51,51.5ALLYL CYCLOHEXYL PROPIONATEALLYL CYCLOHEXYL PROPIONATE3,03.03,03.0ALLYL HEPTOATEALLYL HEPTOATE2,52.52,52.5MELOZONEMELOZONE2,02.02,02.0CALONE 1951CALONE 19510,50.50,50.5MUGETANOLMUGETANOL10,010.010,010.0LINALOOLLINALOOL25,025.025,025.0DIMETHYL BENZYL CARBINYL ACETATEDIMETHYL BENZYL CARBINYL ACETATE6,06.06,06.0DIMETHYL BENZYL CARBINYL BUTYRATDIMETHYL BENZYL CARBINYL BUTYRATE4,04.04,04.0PHENYLETHYL ACETATEPHENYLETHYL ACETATE1,51.51,51.5PHENYLETHYL ALCOHOLPHENYLETHYL ALCOHOL15,015.015,015.0CITRONELLOL 950CITRONELLOL 95010,010.010,010.0GERANIOL SUPERGERANIOL SUPER5,05.05,05.0GERANYL ACETATE PUREGERANYL ACETATE PURE15,015.015,015.0ISODAMASCON(R)Isodamascone (R)2,02.02,02.0BENZYL ACETATEBENZYL ACETATE15,015.015,015.0HEDIONEHEDIONE90,090.090,090.0HEXYL CINNAMIC ALDEHYDE ALPHAHEXYL CINNAMIC ALDEHYDE ALPHA35,035.035,035.0JASMONE CISJASMONE CIS0,50.50,50.5BENZYL SALICYLATEBENZYL SALICYLATE80,080.080,080.0HEXENYL SALICYLATE CIS-3HEXENYL SALICYLATE CIS-330,030.030,030.0ISORALDEINE 70ISORALDEINE 7035,035.035,035.0HERBAFLORATHERBAFLORAT15,015.015,015.0ISO E SUPERISO E SUPER15,015.015,015.0ISOBORNYL CYCLOHEXANOLISOBORNYL CYCLOHEXANOL30,030.030,030.0BRAHMANOL(R)Brahmanol (R)10,010.010,010.0AMBROXIDEAMBROXIDE1,51.51,51.5GLOBALIDE(R)GLOBALIDE (R)5,05.05,05.0GALAXOLIDE 50 % IN DPGGALAXOLIDE 50% IN DPG120,0120.0120,0120.0**3-\\[(4 _R_)-4-Isopropylcyclohexen-1-yl\\]propanal3 - propanal \\[(4 _R)_ -4-Isopropylcyclohexen-1-yl\\]****65,065.0**DIPROPYLENE GLYCOLDIPROPYLENE GLYCOL290,0290.0225,0225.01.000,01,000.01.000,01,000.0\\ \\ Bei einer Dosierung von 0.5 Gew.- % des Parf\u00fcm\u00f6ls G1 bzw. G2 im Shampoo ergibt sich folgender Befund: der Zusatz 3-\\[(4 _R_)-4-Isopropylcyclohexen-1-yl\\]propanal verst\u00e4rkt in dem das Parf\u00fcm\u00f6l G2 enthaltenden Shampoo den w\u00e4ssrigen-fruchtigen Charakter gegen\u00fcber dem Shampoo, welches das Parf\u00fcm\u00f6l G1 (ohne 3-\\[(4 _R_)-4-Isopropylcyclohexen-1-yl\\]propanal) enth\u00e4lt. Zudem ist in dem Shampoo mit dem Parf\u00fcm\u00f6l G2 die Diffusivit\u00e4t erh\u00f6ht gegen\u00fcber dem Shampoo mit der Parf\u00fcm\u00f6l G1.At a dosage of 0.5% by weight of the perfume oil G1 and G2 in the shampoo to the following findings obtained: the addition of 3 - \\[-4-Isopropylcyclohexen-1-yl (4 _R)\\]_ propanal shampoo amplified in the perfume oil G2 containing the aqueous fruity character compared to the shampoo, which (without 3 - \\[(4 _R)_ -4-Isopropylcyclohexen-1-yl\\] propanal) the perfume oil contains G1. In addition, in the shampoo with the perfume oil G2, the diffusivity increases over the shampoo with the perfume oil G1.\\ \\ **BEISPIEL 16AEXAMPLE 16A**Duschgel (Mengenangaben als Gew.-%)Shower gel (amount as wt .-%)\\ \\ **Materialmaterial****HerstellerManufacturer****INCI-NameINCI name****Anteilproportion of**Entionisiertes WasserDeionized waterWasserwater76,376.3Plantacare PS 10Plantacare PS 10Cognis Deutschland GmbHCognis Germany GmbHSodium Laureth Sulfate, Lauryl GlucosideSodium Laureth Sulfate, Lauryl Glucoside20,020.0Dragocid LiquidDragocid LiquidSymriseSymrisePhenoxyethanol, Methylparaben, Ethylparaben, Butylparaben, Propylparaben, IsobutylparabenPhenoxyethanol, methylparaben, ethylparaben, butylparaben, propylparaben, isobutylparaben0,50.5Natriumchloridsodium chlorideSodium ChlorideSodium Chloride1,41.4Citronens\u00e4ure Monohydrat kristallinCitric acid monohydrate crystallineCitric AcidCitric Acid1,31.3Parfum\u00f6l G1 bzw. G2 aus Beispiel 15Perfume oil G1 or G2 from Example 15SymriseSymriseParfum (Fragrance)Perfume (fragrance)0,50.5\\ \\ Bei einer Dosierung von 0.5 Gew.- % des Parf\u00fcm\u00f6ls G1 bzw. G2 im Duschgel ergibt sich folgender Befund: der Zusatz von 3-\\[(4 _R_)-4-Isopropylcyclohexen-1-yl\\]propanal verleiht dem das Parf\u00fcm\u00f6l G2 enthaltenden Duschgel eine nat\u00fcrlichere und pflegendere Note gegen\u00fcber dem Duschgel, welches das Parf\u00fcm\u00f6l G1 (ohne 3-\\[(4 **R**)-4-Isopropylcyclohexen-1-yl\\]propanal) enth\u00e4lt.At a dosage of 0.5% by weight of the perfume oil G1 and G2 in the gel is the following results obtained: the addition of 3 - \\[(4 _R)_ -4-Isopropylcyclohexen-1-yl\\] propanal gives the gel the perfume oil G2 containing a natural and pflegendere Note opposite the shower gel, which (without 3 - \\[(4 **R)** -4-Isopropylcyclohexen-1-yl\\] propanal) the perfume oil contains G1.\\ \\ **BEISPIEL 17AEXAMPLE 17A**Transparente Deo-Stifte (Formulierungen A und B) bzw. Deo-Creme-Stifte (Formulierungen C und D) (Mengenangaben als Gew.-%)Transparent deodorant sticks (formulations A and B) or deodorant cream sticks (formulations C and D) (amounts in% by weight)\\ \\ **KOMPONENTECOMPONENT****AA****BB****CC****DD**Aluminium Zirconium Tetrachlorohydrat - Glycin KomplexAluminum zirconium tetrachlorohydrate - glycine complex25,0025,0020,0020.0025,0025,0020,0020.00Dimethicon (10 Cst)Dimethicone (10 Cst)----5,005.005,005.00Cyclopentasiloxancyclopentasiloxane--0,500.501,001.000,500.50Petrolatumpetrolatum5,005.004,704.705,005.005,005.00Ozokeritozokerite1,001.001,501.50----Stearylalkoholstearyl12,0012,0012,0012,00----2-Butyloctans\u00e4ure2-butyl octanoic0,500.50--0,500.50--Wachswax----1,251.251,251.25PPG-14 ButyletherPPG-14 butyl ether9,009.009,009.00----Geh\u00e4rtetes Raps\u00f6lHardened rapeseed oil----5,005.005,005.00Siliciumdioxidsilica----1,001.00--Farnesolfarnesol0,250.25--0,250.25--Paraffin\u00f6lparaffin oil0,500.500,500.50----Hydriertes Rizinus\u00f6l (castor wax)Hydrogenated castor oil (castor wax)3,503.503,503.50----Talktalc4,004.004,004.00----Behenylalkoholbehenyl0,200.200,200.20----d-Panthenyltriacetatd-panthenyl1,001.001,001.00----Konservierungsmittelpreservativeq.s.q.s.q.s.q.s.q.s.q.s.q.s.q.s.Parf\u00fcm\u00f6l H1 bzw. H2Perfume oil H1 or H21,501.50--1,151.15--Parf\u00fcm\u00f6l G2 aus Beispiel 15Perfume oil G2 from Example 150,900.90--0,750.75WasserwaterAd 100Ad 100Ad 100Ad 100Ad 100Ad 100Ad 100Ad 100\\ \\ **BEISPIEL 17BEXAMPLE 17B**Zusammensetzung des Parf\u00fcm\u00f6ls H1 bzw. H2 (Mengenangaben als Gew.-%)Composition of the perfume oil H1 or H2 (amounts in% by weight)\\ \\ **RIECHSTOFFEfragrances****Parf\u00fcm\u00f6l H1 (Vergleich)Perfume oil H1 (comparative)****Parf\u00fcm\u00f6l H2 (Erfindugsgem\u00e4\u00df)Perfume oil H2 (according to the invention)**ALDEHYDE C10ALDEHYDE C100,50.50,50.5ALDEHYDE C12 MNA 10 % DPGALDEHYDE C12 MNA 10% DPG2,02.02,02.0MINTONATMINTONAT40,040.040,040.0MELOZONEMELOZONE0,50.50,50.5VERTOCITRALVERTOCITRAL6,06.06,06.0DIHYDRO MYRCENOLDIHYDRO MYRCENOL120,0120.0120,0120.0TETRAHYDRO MYRCENOLTETRAHYDRO MYRCENOL10,010.010,010.0AGRUNITRILAGRUNITRIL1,01.01,01.0ORANGE OIL BRASILORANGE OIL BRASIL10,010.010,010.0TAMARINE TYPE BASETAMARINE TYPE BASE10,010.010,010.0HEXYLACETATEHEXYLACETATE6,06.06,06.0ALDEHYDE C14 SO-CALLEDALDEHYDE C14 SO-CALLED1,01.01,01.0TETRAHYDRO LINALOOLTETRAHYDRO LINALOOL40,040.040,040.0DIMETHYL BENZYL CARBINYL BUTYRATDIMETHYL BENZYL CARBINYL BUTYRATE5,05.05,05.0ORANGE FLOWER ETHERORANGE FLOWER ETHER5,05.05,05.0PHENYLETHYL ACETATEPHENYLETHYL ACETATE6,56.56,56.5PHENYLETHYL ALCOHOLPHENYLETHYL ALCOHOL15,015.015,015.0GERANIOL SUPERGERANIOL SUPER30,030.030,030.0ROSAPHEN(R)Rosaphen (R)25,025.025,025.0ISODAMASCON(R)Isodamascone (R)0,50.50,50.5HEDIONEHEDIONE300,0300.0300,0300.0UNDECAVERTOLundecavertol0,50.50,50.5ALLYL IONONEALLYL IONONE2,52.52,52.5IONONE BETAIONONE BETA10,010.010,010.0EUGENOLEUGENOL4,04.04,04.0ISO E SUPERISO E SUPER30,030.030,030.0BRAHMANOL(R)Brahmanol (R)2,02.02,02.0AMBROXIDEAMBROXIDE2,02.02,02.0GLOBALIDE(R)GLOBALIDE (R)12,012.012,012.0GLOBANONE(R)GLOBANONE (R)8,08.08,08.0MACROLIDE(R) SUPRAMACROLIDE (R) SUPRA45,045.045,045.03-\\[(4 _R_)-4-Isopropylcyclohexen-1-yl\\]propanal3 - propanal \\[(4 _R)_ -4-Isopropylcyclohexen-1-yl\\]50,050.0DIPROPYLENE GLYCOLDIPROPYLENE GLYCOL300,0300.0250,0250.01.000,01,000.01.000,01,000.0\\ \\ **BEISPIEL 18EXAMPLE 18**Antiperspirant-Roll-On (Mengenangaben als Gew.-%)Antiperspirant roll-on (amounts in% by weight)\\ \\ **Komponentecomponent****AA****BB**Caprylyl Trimethicon (SilCare TM Silicone 31 M 50)Caprylyl trimethicone (SilCare \u2122 Silicone 31 M 50)0,300.300,300.30Steareth-20 (GENAPOL TM HS 200)Steareth-20 (GENAPOL \u2122 HS 200)3,003.003,003.00Steareth-2 (GENAPOLTM HS 020)Steareth-2 (GENAPOLTM HS 020)1,501.501,501.50Dicaprylyl Ether (Cetiol TM \u00d6)Dicaprylyl ether (Cetiol \u2122 \u00d6)2,002.002,002.00Coco Caprylat/Caprat (Cetiol TM LC)Coco Caprylate / Caprate (Cetiol TM LC)2,002.002,002.00Glyceringlycerin2,002.002,002.00Glyceryl Stearat (Cutina TM GMS)Glyceryl Stearate (Cutina TM GMS)2,002.002,002.00Octyldodecanol (Eutanol TM G)Octyldodecanol (Eutanol \u2122 G)1,001.001,001.00Stearyl alkoholStearyl alcohol2,502.502,502.50Aluminiumchlorohydrat gem\u00e4ss Beispiel 1 der EP 1321431Aluminum chlorohydrate according to Example 1 of EP 1321431 10,0010.0010,0010.00Avocado Extract Persea GratissimaAvocado Extract Persea Gratissima0,300.300,200.20Parf\u00fcm\u00f6l G2 aus Beispiel 15Perfume oil G2 from Example 150,500.50--Parf\u00fcm\u00f6l H2 aus Beispiel 17Perfume oil H2 from Example 17--0,600.60WasserwaterAd 100Ad 100Ad 100Ad 100\\ \\ **BEISPIEL 19EXAMPLE 19**Antiperspirant-Stick (Mengenangaben als Gew.-%)Antiperspirant stick (amount as wt .-%)\\ \\ **Komponentecomponent****AA****BB**Phenyl Trimethicon (SilCare TM Silicone 15 M 50)Phenyl Trimethicone (SilCare \u2122 Silicone 15 M 50)13,5013.5013,5013.50Cetearyl AlkoholCetearyl alcoholAd 100Ad 100Ad 100Ad 100Cetiol CC (Dicaprylyl Carbonat)Cetiol CC (dicaprylyl carbonate)13,5013.5013,5013.50Stearins\u00e4urestearic acid3,503.503,503.50PEG-40-Hydriertes Rizinus\u00f6l (Emulsogen TM HCO 040)PEG-40 hydrogenated castor oil (Emulsogen \u2122 HCO 040)4,104.104,104.10PEG-8 Distearate (Cithrol 4 DS)PEG-8 distearate (Cithrol 4 DS)4,104.104,104.10Petrolatumpetrolatum6,906.906,906.90Aluminiumchlorohydrataluminum chlorohydrate13,8013.8013,8013.80Aluminium Zirconium Trichlorohydrex GlyAluminum Zirconium Trichlorohydrex Gly19,5019.5020,0020.00Ethylhexylglycerin (Octoxyglycerin)Ethylhexylglycerol (octoxyglycerol)0,300.300,200.204-Methyl-4-phenyl-2-pentanol (Vetikol)4-methyl-4-phenyl-2-pentanol (Vetikol)0,250.250,100.10Parf\u00fcm\u00f6l A2 aus Beispiel 9Perfume oil A2 from Example 91,001.00--Parf\u00fcm\u00f6l G2 aus Beispiel 15Perfume oil G2 from Example 15--0,800.80\\ \\ **BEISPIEL 20EXAMPLE 20**Aerosolspray (Mengenangaben als Gew.-%)Aerosol spray (amount as wt .-%)\\ \\ **Komponentecomponent****AA****BB****CC**Octyldodecanoloctyldodecanol0,500.50--0,500.50Phenoxyethanolphenoxyethanol----0,300.301,2-Pentandiol1,2-pentanediol1,001.001,001.000,500.501,2-Hexandiol1,2-hexanediol0,250.250,150.150,250.251,2-Octandiol1,2-octanediol0,250.250,250.250,250.25Farnesolfarnesol--0,250.250,150.15Ethylhexylglycerin (Octoxyglycerin)Ethylhexylglycerol (octoxyglycerol)0,500.500,300.300,500.50Parf\u00fcm\u00f6l A2 aus Beispiel 9Perfume oil A2 from Example 90,800.80--0,500.50Parf\u00fcm\u00f6l H2 aus Beispiel 17Perfume oil H2 from Example 17--1,151.150,500.50EthanolethanolAd 100Ad 100Ad 100Ad 100Ad 100Ad 100\\ \\ Die nach Zusammenmischen der jeweils angegebenen Komponenten erhaltene Mischung wird mit einem Propan-Butan-Gemisch (2:7) im Gewichtsverh\u00e4ltnis 2 : 3 in einen Aerosolbeh\u00e4lter abgef\u00fcllt.The mixture obtained after mixing together the specified components is filled with a propane-butane mixture (2: 7) in a weight ratio of 2: 3 in an aerosol container.\\ \\ **BEISPIEL 21EXAMPLE 21**Haarconditioner mit UV-Schutz (Mengenangaben als Gew.-%)Hair conditioner with UV protection (amount as wt .-%)\\ \\ **Komponentecomponent****INCI NameINCI name****AA****BB**Lanette OLanette OCetearyl AlcoholCetearyl Alcohol4,004.004,004.00Dragoxat 89Dragoxat 89Ethylhexyl IsononanoateEthylhexyl isononanoate4,004.004,004.00EmulsiphosEmulsiphosPotassium Cetyl Phosphate, Hydrogenated Palm GlyceridesPotassium Cetyl Phosphate, Hydrogenated Palm Glycerides0,500.500,500.50Natrosol 250 HRNatrosol 250 HRHydroxyethylcellulosehydroxyethyl0,250.250,250.25Neo Heliopan HydroNeo Heliopan HydroPhenylbenzimidazole Sulfonic AcidPhenylbenzimidazole sulfonic acid2,002.002,002.00L- ArgininL-arginineArginineArginine1,201.201,201.20Benzophenon-4Benzophenone-4Benzophenone-4Benzophenone-40,500.500,500.50Neo Heliopan APNeo Heliopan APDisodium Phenyl Dibenzimidazole TetrasulfonateDisodium phenyl dibenzimidazole tetrasulfonates0,500.501,001.00Edeta BDEdeta BDDisodium EDTADisodium EDTA0,050.050,050.05Dragocide LiquidDragocide LiquidPhenoxyethanol (and) Methylparaben (and) Butyparaben (and) Ethyparaben (and) PropylparabenPhenoxyethanol (and) Methylparaben (and) Butyparaben (and) Ethyparaben (and) Propylparaben0,800.800,800.80Dow Corning 949 Cationic EmulsionDow Corning 949 Cationic EmulsionAmodimethicone, Cetrimonium Chloride, Trideceth-12Amodimethicone, Cetrimonium Chloride, Trideceth-122,002.002,002.00Dow Corning 5200Dow Corning 5200Laurylmethicone CopolyolLaurylmethicone copolyol0,500.500,500.50Parf\u00fcm\u00f6l B2Perfume oil B2ParfumPerfume0,950.95--Parf\u00fcm\u00f6l H2Perfume oil H2ParfumPerfume1,251.25WasserwaterWater (Aqua)Water (aqua)Ad 100Ad 100Ad 100Ad 100\\ \\ **BEISPIEL 22EXAMPLE 22**Sonnenschutzspray (Mengenangaben als Gew.-%)Sunscreen spray (amounts in% by weight)\\ \\ **Phasephase****Rohstofferaw materials****INCI BezeichnungINCI name****Anteilproportion of****AA**Wasser, demineralisiertWater, demineralizedWater (Aqua)Water (aqua)69,5069,50GlyceringlycerinGlyceringlycerin4,004.001,3 Butylenglykol1,3 butylene glycolButylene GlycolButylene glycol5,005.00D-PanthenolD-panthenolPanthenolpanthenol0,500.50Lara Care A-200Lara Care A-200GalactoarabinanGalactoarabinan0,250.25**BB**Baysilone\u00f6l M 10Baysilone oil M 10DimethiconeDimethicone1,001.00Edeta BDEdeta BDDisodium EDTADisodium EDTA0,100.10Copherol 1250Copherol 1250Tocopheryl AcetateTocopheryl acetate0,500.50Cetiol \u00d6Cetiol \u00d6Dicaprylyl EtherDicaprylyl ether3,003.00Neo Heliopan (R) HMSNeo Heliopan (R) HMSHomosalateHomosalate5,005.00Neo Heliopan (R) AVNeo Heliopan (R) AVEthylhexyl MethoxycinnamateEthylhexyl methoxycinnamate6,006.00Neo Heliopan(R) 357Neo Heliopan (R) 357Butyl MethoxydibenzoylmethaneButyl methoxydibenzoylmethane1,001.00Corapan TQCorapan TQDiethylhexylnaphthalateDiethylhexylnaphthalate2,002.00Alpha BisabololAlpha bisabololBisabololbisabolol0,100.10Pemulen TR-2Pemulen TR-2Acrylates/C10-30 Alkyl Acrylate CrosspolymerAcrylates / C10-30 Alkyl Acrylate Crosspolymer0,250.25**CC**PhenoxyethanolphenoxyethanolPhenoxyethanolphenoxyethanol0,700.70Solbrol MSolbrol MMethylparabenmethylparaben0,200.20Solbrol PSolbrol PPropylparabenPropylparaben0,100.10**DD**NaOH, 10 % igNaOH, 10%Sodium HydroxideSodium hydroxides0,600.60**Ee**Parf\u00fcm\u00f6l B2Perfume oil B2Fragrance (Parfum)Fragrance (perfume)0,200.20\\ \\ Herstellungsverfahren: Lara Care A-200 unter R\u00fchren in den anderen Bestandteilen von Teil A l\u00f6sen. Alle Rohstoffe des Teils B (ohne Pemulen) einwiegen und die kristallinen Substanzen unter Erw\u00e4rmen l\u00f6sen. Pemulen eindispergieren. Teil B zu Teil A geben und 1 Minute homogenisieren. Teile C-E zugeben und nochmals 1-2 Minuten mit dem Ultra Turrax homogenisieren.Method of preparation: Dissolve Lara Care A-200 with stirring in the other components of Part A. Weigh all raw materials of part B (without pemulen) and dissolve the crystalline substances by heating. Disperse pemulen. Add part B to part A and homogenize for 1 minute. Add parts C-E and homogenize with the Ultra Turrax for another 1-2 minutes.\\ \\ **BEISPIEL 23EXAMPLE 23**Sonnenschutz Softcreme (W/O). Lichtschutzfaktor (SPF) 40 (Mengenangaben als Gew.-%)Sunscreen soft cream (W / O). Sun protection factor (SPF) 40 (amounts in% by weight)\\ \\ **Phasephase****Rohstofferaw materials****INCI BezeichnungINCI name****Anteilproportion of****AA**Dehymuls PGPHDehymuls PGPHPolyglyceryl-2 DipolyhydroxystearatePolyglyceryl-2 dipolyhydroxystearates5,005.00Copherol 1250Copherol 1250Tocopheryl acetateTocopheryl acetate0,500.50Permulgin 3220Permulgin 3220Ozokeriteozocerites0,500.50Zinkstearatzinc stearateZinc StearateZinc stearate0,500.50Tegosoft TNTegosoft TNC12-15 Alkyl BenzoateC12-15 alkyl benzoates10,0010.00Neo Heliopan(R) E1000Neo Heliopan (R) E1000Isoamyl-p-MethoxycinnamateIsoamyl p-methoxycinnamate2,002.00Neo Heliopan(R) 303Neo Heliopan (R) 303OctocryleneOctocrylene5,005.00Neo Heliopan(R) MBCNeo Heliopan (R) MBC4-Methylbenzylidene Camphor4-methylbenzylidene camphor3,003.00Zinkoxid neutralZinc oxide neutralZinc OxideZinc oxides5,005.00BBWasser, destilliertWater, distilledWater (Aqua)Water (aqua)Ad 100Ad 100EDETA BDEDETA BDDisodium EDTADisodium EDTA0,100.10GlyceringlycerinGlyceringlycerin4,004.00PhenoxyethanolphenoxyethanolPhenoxyethanolphenoxyethanol0,700.70Solbrol MSolbrol MMethylparabenmethylparaben0,200.20Solbrol PSolbrol PPropylparabenPropylparaben0,100.10Magnesiumsulfatmagnesium sulfateMagnesium SulfateMagnesium sulphates0,500.50**CC**Parf\u00fcm\u00f6l B2 aus Beispiel 10Perfume oil B2 from Example 10Parfum (Fragrance)Perfume (fragrance)0,300.30\\ \\ Herstellungsverfahren: Teil A auf ca. 85 \u00b0C erhitzen. Teil B (ohne Zinkoxid) auf ca. 85 \u00b0C erhitzen; Zinkoxid mit dem Ultra Turrax eindispergieren. B zu A geben. Unter R\u00fchren abk\u00fchlen lassen. Teil C zugeben und anschlie\u00dfend homogenisieren.Method of preparation: Heat part A to approx. 85 \u00b0 C. Heat part B (without zinc oxide) to about 85 \u00b0 C; Zinc oxide with the Ultra Turrax einispergieren. Give B to A. Allow to cool while stirring. Add Part C and then homogenize.\\ \\ **BEISPIEL 24EXAMPLE 24**Sonnenschutzmilch (W/O) (Mengenangaben als Gew.-%)Sunscreen milk (W / O) (amounts in% by weight)\\ \\ **Phasephase****Rohstofferaw materials****INCI BezeichnungINCI name****Anteilproportion of****AA**Dehymuls PGPHDehymuls PGPHPolyglyceryl-2 DipolyhydroxystearatePolyglyceryl-2 dipolyhydroxystearates3,003.00Bienenwachs 8100Beeswax 8100BeeswaxBeeswax1,001.00Monomuls 90-0-18Monomuls 90-0-18Glyceryl OleateGlyceryl Oleate1,001.00Zinkstearatezinc stearateZinc stearateZinc stearate1,001.00Cetiol SNCetiol SNCetearyl IsononanoateCetearyl Isononanoate5,005.00Cetiol \u00d6Cetiol \u00d6Dicaprylyl EtherDicaprylyl ether5,005.00Tegosoft TNTegosoft TNC12-15 Alkyl BenzoateC12-15 alkyl benzoates4,004.00Vitamin EVitamin ETocopheroltocopherol0,500.50Solbrol PSolbrol PPropylparabenPropylparaben0,100.10Neo Heliopan(R) OSNeo Heliopan (R) OSEthylhexyl SalicylateEthyl hexyl salicylates5,005.00Neo Heliopan(R) AVNeo Heliopan (R) AVEthylhexyl MethoxycinnamateEthylhexyl methoxycinnamate7,507.50Uvinul(R) T150Uvinul (R) T150Ethylhexyl TriazoneEthylhexyl triazone1,501.50**BB**Wasser, destilliertWater, distilledWater (Aqua)Water (aqua)Ad 100Ad 100Trilon BDTrilon BDDisodium EDTADisodium EDTA0,100.10GlyceringlycerinGlyceringlycerin5,005.00Solbrol MSolbrol MMethylparabenmethylparaben0,200.20PhenoxyethanolphenoxyethanolPhenoxyethanolphenoxyethanol0,700.70Neo Heliopan(R) AP 10 % ige L\u00f6sung, neutralisiert mit NaOHNeo Heliopan (R) AP 10% solution neutralized with NaOHDisodium Phenyl Dibenzimidazole TetrasulfonateDisodium phenyl dibenzimidazole tetrasulfonates15,0015.00**CC**Parf\u00fcm\u00f6l G2 aus Beispiel 15Perfume oil G2 from Example 15Parfum (Fragrance)Perfume (fragrance)0,250.25Alpha BisabololAlpha bisabololBisabololbisabolol0,100.10\\ \\ Herstellungsverfahren: Teil A auf ca. 85 \u00b0C erhitzen. Teil B auf ca. 85 \u00b0C erhitzen. B zu A geben. Unter R\u00fchren abk\u00fchlen lassen. Teil C zugeben und anschlie\u00dfend homogenisieren.Method of preparation: Heat part A to approx. 85 \u00b0 C. Heat part B to approx. 85 \u00b0 C. Give B to A. Allow to cool while stirring. Add Part C and then homogenize.\\ \\ **BEISPIEL 25AEXAMPLE 25A**Permanent-Haarf\u00e4rbemittel Teil AHaarf\u00e4rbungsbase (Mengenangaben als Gew.-%)Permanent Hair Dye Part AHair Dyeing Base (amount by weight%)\\ \\ **Rohstofferaw materials****Anteilproportion of**Natrium Myreth Sulfat (z. B. Texapon K14 S/K, Cognis)Sodium myreth sulfate (eg Texapon K14 S / K, Cognis)2,802.80Linoleamidopropyl PG-dimonium chlorid phosphat (Arlasilk Phospholipid EFA, Uniqema)Linoleamidopropyl PG-dimonium chloride phosphate (Arlasilk Phospholipid EFA, Uniqema)1,001.00Caprylyl- / Capryl glucosid (Plantacare 810 UP, Cognis)Caprylyl / capryl glucoside (Plantacare 810 UP, Cognis)2,002.00Natrium Laureth-6 Carboxylat (Akypo Soft 45 NV, Kao)Sodium Laureth-6 Carboxylate (Akypo Soft 45 NV, Kao)10,0010.00Cetearylalkoholcetearyl8,008.00Octyldodecanoloctyldodecanol1,001.00Ceteareth-12Ceteareth-120,500.50Ceteareth-20Ceteareth-200,500.50KOH, 50 % ig in WasserKOH, 50% in water0,700.70Toluol-2,5-diamine sulfat (oxidierende Farbstoff)Toluene-2,5-diamine sulfate (oxidizing dye)0,900.90Resorcinresorcinol0,200.20m-aminophenolm-aminophenol0,060.064-chlororesorcin4-chlororesorcin0,150.15Ascorbins\u00e4ureascorbic acid0,100.10Natriumsulfitsodium0,150.15Ammoniak, 25 % in WasserAmmonia, 25% in water6,006.00Etidrons\u00e4ureetidronic0,200.20Polyquaternium-2 (Mirapol A15, Rhodia)Polyquaternium-2 (Mirapol A15, Rhodia)0,200.20Parf\u00fcm\u00f6l G2 aus Beispiel 15Perfume oil G2 from Example 150,300.30Wasserwater65,2465.24\\ \\ **BEISPIEL 25AEXAMPLE 25A**Permanent-Haarf\u00e4rbemittel Teil B - Entwickler (Mengenangaben als Gew.-%)Permanent Hair Dye Part B - Developer (by weight%)\\ \\ **Rohstoffe****Anteil**Ketostearylalkohol8.00Ceteareth-202.50Steartrimonium Chlorid (Dehyquart B, Cognis)1.002,6-dicarboxypyridin0.10Paraffin\u00f6l0.30Etidrons\u00e4ure0.40Propylenglykol0.40Natriumbenzoat0.04Wasserstoffperoxid, 50 % in Wasser12.00KOH, 50 % in Water, zugegeben bis pH = 3.5q.s.WasserAd 100\\ Anwendung: Die erfindungsgem\u00e4\u00dfe Haarf\u00e4rbungsbasis (Teil A) und der erfindungsgem\u00e4\u00dfe Entwickler (Teil B) werden in einem Gewichtsverh\u00e4ltnis von 1:1 Verh\u00e4ltnis zusammen ger\u00fchrt und auf die Haare aufgetragen.**raw materials****proportion of** cetostearyl 8:00 Ceteareth-20 2:50 Steartrimonium chloride (Dehyquart B, Cognis) 1:00 2,6-dicarboxypyridine 12:10 paraffin oil 12:30 etidronic 12:40 propylene glycol 12:40 sodium benzoate 12:04 Hydrogen peroxide, 50% in water 12:00 KOH, 50% in water, added until pH = 3.5 qs water Ad 100 Application: The hair coloring base (part A) according to the invention and the developer according to the invention (part B) are stirred together in a weight ratio of 1: 1 ratio and applied to the hair.\\ \\ **BEISPIEL 26EXAMPLE 26**Haarf\u00e4rbungscreme f\u00fcr eine blonde Farbt\u00f6nung (Mengenangaben als Gew.-%)Hair dyeing cream for a blonde tint (amounts in% by weight)\\ \\ **Phasephase****Materialmaterial****HerstellerManufacturer****INCI-NameINCI name****Anteilproportion of****AA**OxowaxOxowaxLCWLCWCethyl alcohol, Oleyl alcohol, Cetearyl alcohol, Stearic acidCethyl alcohol, oleyl alcohol, cetearyl alcohol, stearic acid21,0021,00Volpo CS 25Volpo CS 25CrodaCrodaCeteareth25Ceteareth254,004.00Berol 175175Brenntag EurochemBrenntag EurochemLaureth-8Laureth-810,0010.00Lanette(R) ELanette (R) ECognisCognisSodium Cetearyl SulfateSodium Cetearyl Sulfate1,001.00Covaquat 16Covaquat 16LCWLCWPolyquaternium-6Polyquaternium-64,004.00WasserwaterWater (Aqua)Water (aqua)49,3049,30**BB**Ammoniak (20 % in Wasser)Ammonia (20% in water)Merk EurolabMerk EurolabAmmoniaAmmonia10,2010.20**CC**Parf\u00fcm\u00f6l G2Perfume oil G2SymriseSymriseParfumPerfume0,500.50\\ \\ Herstellungsverfahren: Teil A, B und C au\u00dfer Covaquat 16 zusammen mischen und 20 Minuten bei 80 \u00b0C erhitzen. Nachdem das Produkt homogen ist, abk\u00fchlen lassen. Covaquat 16 bei 50 \u00b0C dazugeben. Wenn das Produkt anf\u00e4ngt zu verdicken die R\u00fchrung stoppen. Bei Raumtemperatur NH4OH dazugegeben und die Mischung bis zur Homogenisierung r\u00fchren.Method of preparation: Mix together parts A, B and C except Covaquat 16 and heat at 80 \u00b0 C for 20 minutes. After the product is homogeneous, allow to cool. Add Covaquat 16 at 50 \u00b0 C. When the product starts thickening stop the stirring. NH 4 OH is added at room temperature and the mixture is stirred until homogenization.\\ \\ **BEISPIEL 27EXAMPLE 27**Lufterfrischer Aerosolspray, aus Wasserbasis (w/o Alkohol) (Mengenangaben als Gew.-%)Air freshener aerosol spray, water-based (w / o alcohol) (amounts in% by weight)\\ \\ **Materialmaterial****HerstellerManufacturer****INCI-NameINCI name****Anteilproportion of**Imbentin C/125/030Imbentin C / 125/030SymriseSymriseC12-15 pareth-3C12-15 pareth-30,250.25Imbentin AG/100/080Imbentin AG / 100/080SymriseSymrisedeceth-8, Ziegler alcoholdeceth-8, Ziegler alcohol1,001.00Parf\u00fcm\u00f6l H2 aus Beispiel 17Perfume oil H2 from Example 17SymriseSymriseParfumPerfume1,251.25Wasser, demineralisiertWater, demineralizedAquaAqua22,5022,50Treibgas 4,2 barPropellant gas 4.2 bar75,0075.00\\ \\ Herstellungsverfahren: Alle Rohstoffe in der angegebenen Reihenfolge zusammenmischen.Method of preparation: Mix all raw materials together in the order listed.\\ \\ **BEISPIEL 28EXAMPLE 28**Fl\u00fcssiges Lufterfrischer Pumpspray (Mengenangaben als Gew.-%)Liquid air freshener pump spray (amounts in% by weight)\\ \\ **Meterialmeterial****HerstellerManufacturer****INCI-NameINCI name****Anteilproportion of**Wasser, demineralisiertWater, demineralizedAquaAqua90,7090,70Ethanol 96 %Ethanol 96%SymriseSymriseEthanolethanol4,004.00Empilan KCL 11/90Empilan KCL 11/90Stockmeierstock MeierAlcohol C12-15 11EOAlcohol C12-15 11EO3,003.00IsopropanolisopropanolSymriseSymrisePropan-2-olPropane-2-ol1,001.00Natriumhydrogencarbonat p.A..Sodium hydrogencarbonate p.A ..SymriseSymriseSodiumbicarbonatsodium bicarbonate0,200.20Parmetol A 26Parmetol A 26H\u00f6sch JuliusPanty JuliusMixture of 5-Chloro-2-methyl-2H-isothiazol-3-one and 2-Methyl-2 _H_-isothiazol-3-oneMixture of 5-Chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2 _H_ isothiazole-3-one0,100.10Parf\u00fcm\u00f6l F2Perfume oil F2SymriseSymriseParfumPerfume1,001.00\\ \\ Herstellungsverfahren: Alle Rohstoffe in der angegebenen Reihenfolge zusammen mischen. pH-Wert anpassen.Method of preparation: Mix all raw materials together in the order listed. Adjust pH.\\ \\ **BEISPIEL 29EXAMPLE 29**Deodorierender Lufterfrischer Pumpe/Docht 5 % Duftstoff (Mengenangaben als Gew.-%)Deodorizing air freshener pump / wick 5% perfume (amount as wt%)\\ \\ **Phasephase****Materialmaterial****HerstellerManufacturer****INCI-NameINCI name****Anteilproportion of****AA**Wasser, demineralisiertWater, demineralizedAquaAqua67,3267.32Sequion 40 NA 32Sequion 40 NA 32Polygon ChemiePolygon chemistry1,251.25Triethanolamin pur CPure triethanolamine CSymriseSymriseTriethanolamineTriethanolamine0,300.30Rewoderm S 1333Rewoderm S 1333GoldschmidtGoldschmidtDiNa-Ricinoleamido MEA-SulfosuccinatDiNa-ricinoleamido MEA sulfosuccinate2,332.33Tego Sorb Conc. 50Tego Sorb Conc. 50EvonikEvonikAlcohol C12-14, ethoxylated (2-5 EO) + Zn-RicinoleatAlcohol C12-14, ethoxylated (2-5 EO) + Zn-ricinoleate0,500.50Ethanol 96 %Ethanol 96%SymriseSymriseEthanolethanol20,0020.00**BB**Parf\u00fcm\u00f6l E2Perfume oil E2SymriseSymriseParfumPerfume5,005.00L\u00f6sungsvermittlersolubilizersSymriseSymrise3,003.00**CC**Milchs\u00e4urelactic acidSymriseSymrisePropanoic acid, 2-hydroxypropionic acid, LactolPropanoic acid, 2-hydroxypropionic acid, lactol0,300.30\\ \\ Herstellungsverfahren: Materialien des Teils A in der angegebenen Reihenfolge zusammen mischen. Materialien des Teil B zusammen mischen. Wenn Teil A klar ist, Teil B dazugeben. Anschlie\u00dfend Teil C zugeben und r\u00fchren bis die Mischung homogen ist.Method of preparation: Mix together the materials of Part A in the order listed. Mix materials of part B together. If part A is clear, add part B. Then add part C and stir until the mixture is homogeneous.\\ \\ **BEISPIEL 30EXAMPLE 30**WC-Stein (Mengenangaben als Gew.-%)WC-Stein (quantities as wt .-%)\\ \\ **Phasephase****Materialmaterial****HerstellerManufacturer****INCI-NameINCI name****Anteilproportion of****AA**Imbentin C/125/200Imbentin C / 125/200Dr. W. KolbDr. W. KolbC12/15 pareth-20C12 / 15 pareth-204,004.00Rewomid C 212Rewomid C 212GoldschmidtGoldschmidtCocamide MEACocamide MEA6,006.00Marion ARLMarion ARLSasolSasolC10-13, ABS-Na, PulverC10-13, ABS-Na, powder42,0042,00**BB**Natriumsulfat pharm. (E514)Sodium sulfate pharm. (E514)SymriseSymriseSodium sulfateSodium sulfate42,0042,00Parf\u00fcm\u00f6l F2Perfume oil F2SymriseSymriseParfumPerfume6,006.00\\ \\ Herstellungsverfahren: Teil A schmelzen lassen. Teil B dazu mischen mit Hilfe eines Mischkneters. Im Extruder bei 35-40 \u00b0C zu einem WC-Stein formen.Method of preparation: let part A melt. Mix part B with a mixing mixer. Form in the extruder at 35-40 \u00b0 C to a toilet block.\\ \\ **BEISPIEL 31EXAMPLE 31**Kerze (Mengenangaben als Gew.-%)Candle (quantities as wt .-%)\\ \\ **Materialmaterial****Anteilproportion of**Kerzenwachscandle wax95,0095,00Parf\u00fcm\u00f6l D2Perfume oil D25,005.00\\ \\ Herstellungsverfahren: Das Kerzenwachs schmelzen lassen und r\u00fchren. Das Parf\u00fcm\u00f6l dazugeben, gut r\u00fchren. In die gew\u00fcnschte Form gie\u00dfen.Method of production: Melt the candle wax and stir. Add the perfume oil, stir well. Pour into the desired shape.\\ \\ **BEISPIEL 32EXAMPLE 32**Synthese von 3-\\[(4 _S_)-4-Isopropylcyclohexen-1-yl\\]propanal (Ib)Synthesis of 3 - \\[(4 _S)_ -4- Isopropylcyclohexen-1-yl\\] propanal (Ib)\\ \\ \\ \\ \\ \\ Der Aldehyd 3-\\[(4 _S_)-4-Isopropylcyclohexen-1-yl\\]propanal (Formel (Ib) wie oben definiert) wird ausgehend von I-(-)-Limonen (79.5 % ee, Formel (Vlb) wie oben definiert) analog zu der Synthese von 3-\\[(4 _R_)-4-Isopropylcyclohexen-1-yl\\] propanal (la) (Beispiele 4 bis 8) hergestellt. Das Produkt wird mit einer Reinheit von 97 % und mit 78 % ee erhalten.The aldehyde 3 - \\[(4 _S)_ -4-Isopropylcyclohexen-1-yl\\] propanal (formula (Ib) as defined above) on the basis of I is - (-) - limonene ((79.5% ee, formula VIb) as defined above ) analogous to the synthesis of 3 - (\\[(4 _R)_ -4-Isopropylcyclohexen-1-yl\\] propanal (la) produced Examples 4 to 8). The product is obtained with a purity of 97% and with 78% ee.\\ \\ **BEISPIEL 33EXAMPLE 33**Substantivit\u00e4tsubstantivity\\ \\ Der Substantivit\u00e4tstest ist ein Test zur Bestimmung der sensorischen Haftung eines Stoffes auf Riechstreifen. Die zu untersuchenden Riechstoffe (Verbindung der Formel (la), Verbindung der Formel (Ib) und Lilial\u00ae als Benchmark) werden in Form einer 10 %igen L\u00f6sung in Triethylcitrat (TEC) jeweils auf einen codierten Riechstreifen getaucht und in definierten zeitlichen Abst\u00e4nden von 15 Pr\u00fcfern bez\u00fcglich der Intensit\u00e4t beurteilt. Die 15 Probanden bewerten die Geruchsintensit\u00e4t auf einer Skala von 1 = geruchlos bis 9 = sehr stark. Die Ergebnisse (Geruchsintensit\u00e4t I in Abh\u00e4ngigkeit von der seit dem Eintauchen des Riechstreifen vergangenen Zeit t in Tagen d) sind in Figur 1 dargestellt.The substantivity test is a test for determining the sensory adhesion of a substance to smelling strips. The fragrances to be investigated (compound of the formula (Ia), compound of the formula (Ib) and Lilial\u00ae as benchmark) are in the form of a 10% solution in triethyl citrate (TEC) immersed in each case on a coded smelling strip and at defined time intervals of 15 Examiners assessed the intensity. The 15 subjects rated the odor intensity on a scale from 1 = odorless to 9 = very strong. The results (odor intensity I as a function of the time t since the immersion of the scent strip in days d) are in FIG. 1 shown.\\ \\ Die Geruchsintensit\u00e4t wird in folgenden zeitlichen Abst\u00e4nden nach dem Eintauchen der Riechstreifen bewertet: 1 Stunde oder weniger (in Figur 1 als Zeitpunkt \"0 Tage\" bezeichnet); 1 Tag; 2 Tage; 3 Tage; 4 Tage; 7 Tage; 8 Tage; 9 Tage. Um sicherzustellen, dass die Probanden nicht beeinflusst werden, sind die codierten Riechstreifen nicht in einer chronologischen Reihenfolge auf dem Riechstreifenst\u00e4nder angeordnet.The odor intensity is evaluated at the following intervals after immersion of the smelling strips: 1 hour or less (in FIG. 1 as time \"0 days\"); 1 day; 2 days; 3 days; 4 days; 7 days; 8 days; 9 days. To ensure that the subjects are not affected, the coded smelling strips are not arranged in a chronological order on the smelling strip stand.\\ \\ Die Geruchsintensit\u00e4t der Verbindung der Formel (la) (schwarz ausgef\u00fcllter Balken) wird im frischen Zustand und \u00fcber einen Zeitraum bis zu 3 Tagen von den Probanden im Vergleich zu Lilial\u00ae (schwarz schraffierter Balken) als st\u00e4rker, und nach 4 bis 7 Tagen zumindest vergleichbar mit Lilial\u00ae eingesch\u00e4tzt. Nach 9 Tagen wird sogar erneut eine im Vergleich zu Lilial(R) h\u00f6here Geruchsintensit\u00e4t der Verbindung der Formel (la) beobachtet.The odor intensity of the compound of formula (Ia) (solid black bar) when fresh and over a period of up to 3 days from subjects compared to Lilial\u00ae (black hatched bar) is at least comparable, and after 4 to 7 days at least rated with Lilial\u00ae. After 9 days even a higher odor intensity of the compound of the formula (Ia) is observed again compared with Lilial (R).\\ \\ Auch die Geruchsintensit\u00e4t der Verbindung (Ib) (schwarz gepunkteter Balken) ist im frischen Zustand st\u00e4rker als die von Lilial\u00ae (schwarz schraffierter Balken) und nach einem Tag vergleichbar mit Lilial\u00ae. Danach nimmt die Geruchsintensit\u00e4t der Verbindung der Formel (Ib) zun\u00e4chst st\u00e4rker ab als bei Lilial\u00ae und der Verbindung der Formel (la), nach 7 bis 9 Tagen sind die Werte jedoch vergleichbar oder leicht h\u00f6her als bei Lilial\u00ae.The odor intensity of the compound (Ib) (black dotted bars) in the fresh state is stronger than that of Lilial\u00ae (black hatched bar) and after one day comparable to Lilial\u00ae. Thereafter, the odor intensity of the compound of formula (Ib) initially decreases more than in Lilial\u00ae and the compound of formula (Ia), but after 7 to 9 days, the values are comparable or slightly higher than in Lilial\u00ae.\\ \\ ### Claims (17) Hide Dependent translated from\\ \\ 01. Compound selected from formula (Ia)\\ \\ \\ \\ \\ 02. Mixture, comprising or consisting of\\ \\ \\ (i) a compound of formula (Ia)\\ \\ \\ \\ \\ \\ \\ \\ \\ (ii) a compound of formula (Ib)\\ \\ \\ \\ \\ 03. Mixture of claim 2, **characterized in that**,\\ \\ \\ (a) the mass ratio of the compound of formula (Ia) to the compound of formula (Ib) is in the range from 0.01 to 99.99, preferably in the range from 0.1 to 99.9, preferably in the range from 0.5 to 99.5, preferably in the range from 1.0 to 99.0, preferably in the range from 1.5 to 98.5, preferably in the range from 2.0 to 98.0 and/or\\ \\ \\ \\ (b) the total amount of the compounds of formula (Ia) and (Ib) is greater than 0.01 w.t.%, preferably greater than 1 w.t.%, preferably greater than 10 w.t.%, more preferably greater than 50 w.t.%, most preferred greater than 90 w.t.%, relative to the total weight of the mixture comprising compounds (Ia) and/or (Ib).\\ \\ 04. Use of a compound of formula (Ia) as defined in claim 1 or a mixture consisting of the compound of formula (Ia) as defined in claim 1 and the compound of formula (Ib) as defined in claim 2\\ \\ \\ (i) as fragrance, in particular as lily of the valley fragrance and/or\\ \\ \\ \\ (ii) as an agent for increasing the substantivity and/or the retention of a fragrance preparation; and/or\\ \\ \\ \\ (iii) as fixative.\\ \\ 05. The use of claim 4, wherein\\ \\ \\ (a) the compound of formula (Ia) as defined in claim 1 is used for mediating, modifying or intensifying an odor note of lily of the valley and optionally one, several or all odor notes selected from the group consisting of floral, sweet, watery, powdery and ozone-like; and/or\\ \\ \\ \\ (b) the compound of formula (Ia) as defined in claim 1 is used for mediating, modifying or intensifying an odor note of lily of the valley and optionally one, several or all odor notes selected from the group consisting of fruity, green, watery and aldehyde-like.\\ \\ 06. A fragrance preparation, in particular perfume oil, preferably with an odor note of lily of the valley, consisting of or comprising\\ \\ \\ (i) compound of formula (Ia) as defined in claim 1 or a mixture consisting of the compound of formula (Ia) as defined in claim 1 and the compound of formula (Ib) as defined in claim 2, and\\ \\ \\ \\ (ii) one, 2, 3, 4, 5, 6, 7, 8, 9, 10 or more further fragrances, which are not the compound of formula (I)\\ \\ \\ \\ \\ 07. A fragrance preparation, in particular a perfume oil of claim 6, **characterized in that**, the amount of the formula (Ia) as defined in claim 1 and/or the compound of formula (Ib) as defined in claim 2, is in the range from 0,0001 to 40 w.t.%. preferably in the range from 0,001 to 25 w.t.%, each based on the total weight of the fragrance preparation.\\ \\ 08. A fragrance preparation, in particular a perfume oil according to any of claims 6 or 7, comprising one, 2, 3 or more further fragrances with an odor note of lily of the valley and optionally one, several or all odor notes selected from the group consisting of floral, sweet, watery, ozone-like, woody, ambered, musky, fruity, animal.\\ \\ 09. A fragrance preparation, in particular a perfume oil according to any of claim 6 to 8,\\ \\ \\ (i) the amount of compound of formula (Ia) is sufficient to mediate an odor note of lily of the valley and optionally one, several or all odor notes mediate notes selected from the group consisting of floral, sweet, watery, powdery and ozone-like to the fragrance preparation, and/or\\ \\ \\ \\ (ii) one, several or all further fragrances of the fragrance preparation mediate an odor note of lily of the valley and optionally one, several or all odor notes mediate notes selected from the group consisting of floral, sweet, watery, powdery and ozone-like and the amount of the compound of formula (Ia) is sufficient in comparison to an identical composed comparison fragrance preparation without the compound of formula (Ia) to modify and/or intensify the odor note of lily of the valley and optionally one, several or all odor notes selected from the group consisting of floral, sweet, watery, powdery and ozone-like, and/or\\ \\ \\ \\ (iii) the amount of compound of formula (Ia) is sufficient to mediate an odor note of lily of the valley and optionally one, several or all odor notes mediate notes selected from the group consisting of fruity, green, watery and aldehyde-like to the fragrance preparation, and/or\\ \\ \\ \\ (iv) one, several or all further fragrances of the fragrance preparation mediate an odor note of lily of the valley and optionally one, several or all odor notes mediate notes selected from the group consisting of fruity, green, watery and aldehyde-like and the amount of the compound of formula (Ib) is sufficient in comparison to an identical composed comparison fragrance preparation without the compound of formula (Ib) to modify and/or intensify the odor note of lily of the valley and optionally one, several or all odor notes selected from the group consisting of fruity, green, watery and aldehyde-like.\\ \\ 10. Perfumed product comprising compound of formula (Ia) as defined in claim 1 or a mixture consisting of the compound of formula (Ia) as defined in claim 1 and the compound of formula (Ib) as defined in claim 2, preferably in a sensory effective amount.\\ \\ 11. Perfumed product of claim 10, **characterized in that**, the amount of the formula (Ia) as defined in claim 1 is in the range from 0,0001 to 5 w.t.%. preferably in the range from 0,001 to 2,5 w.t.%, each based on the total weight of the product.\\ \\ 12. Perfumed product of claims 10 or 11, selected from the group consisting of washing and cleaning products, hygiene or care products, in particular from the area of body and hair care, cosmetics and household products, fine fragrance (perfume), air care (especially candles), air fresheners.\\ \\ 13. Method of providing skin, hair, surfaces, or textile fibers with an odor note of lily of the valley comprising the following steps:\\ \\ \\ (a) Providing a fragrance preparation, preferably according to any claims 6 to 9, comprising\\ \\ \\ \\ (b) compounds of the formula (Ia) as defined in claim 1 or a mixture consisting of the compound of formula (Ia) as defined in claim 1 and the compound of formula (Ib) as defined in claim 2, and\\ \\ \\ \\ (c) one or several further fragrances which are not compound of formula (Ia) or (Ib), wherein the amount of compound of formula (I) in the fragrance preparation is sufficient for mediating, modifying and/or intensifying an odor note of lily of the valley;\\ \\ \\ \\ (d) applying the fragrance preparation to the skin, hair, surfaces, or textile fibers.\\ \\ 14. Method for producing the compound of formula (I) as defined in claim 4, comprising the step of acid catalyzed reaction of an acetal of formula (II), so that the compound of formula (I) is formed\\ \\ \\ \\ \\ \\ wherein the group R in the acetal of formula (IIa) is a branched or unbranched, saturated or unsaturated alkyl group with 1 to 10 carbon atoms, preferably a butyl group.\\ \\ 15. Acetal of formula (II)\\ \\ \\ \\ \\ \\ wherein the group R in the acetal of formula (IIa) is a branched or unbranched, saturated or unsaturated alkyl group with 1 to 10 carbon atoms, preferably a butyl group.\\ \\ 16. Use of\\ \\ \\ (i) d-(+) limonene as educt for producing the compound of formula (I) as defined in claim 1, or\\ \\ \\ \\ (ii) a mixture containing d-(+) limonene and 1-(-) limonene as educt for producing a mixture containing the compound of formula (Ia) as defined in claim 1 and the compound of formula (Ib) as defined in claim 2.\\ \\ 17. Method for mediating, intensifying and/or modifying an odor note of lily of the valley and optionally one, several or all odor notes selected from the group consisting of floral, sweet, watery, powdery and ozone-like, comprising the following steps: mixing or bringing in contact of the compound of formula (Ia) as defined in claim 1 or a mixture according toany claims 2 or 3, or a fragrance preparation of any claims 6 to 9, preferably in a sensory effective amount with a product."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": null, "compound_ref_verbatim": null, "confidence": 0.45, "construct": {"method_text_verbatim": "Previous attempts to overcome these problems have been through the use of various \u201cfixatives\u201d or \u201cmodulators\u201d to retard the evaporation of the more volatile fragrance ingredients present in fragrance compositions. For instance, U.S. Pat. No. 4,313,855 (Dragoco) describes the use in cosmetic compositions of 1-(2,6,6-trimethylcyclohexyl)-hexane-3-ol as an odourless fixative for increasing the perfume's intensity. U.S. Pat. No. 6,147,049 (Givaudan) discloses a perfume fixative derived from tera-hydronaphthalenese for use in a wide range of fragrance compositions. U.S. Pat. No. 6,440,400B1 (Takasago Perfumery) describes a composition using trimethylcyclohexane derivatives as perfuming-holding agents and melanin-formation inhibitors. U.S. Pat. No. 6,737,396B2 (Firmenich) describes a perfume composition formed by mixing 2-30%, relative to the weight of the composition, of a fixative, (1-ethoxyethoxy)cyclododecane, to fix or exalt the musky or aromatic-type notes. U.S. Pat. No. 7,538,081 (Tak", "panel_size": null, "property_name": "persistence", "scale": "percent", "substrate": null, "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "2-30; 61-083114; 61-063612; 62-084010", "patent_id": "US10501706B2", "provenance": {"citation": "US10501706B2", "retrieval_source": "Firecrawl scrape of Google Patents public page", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US10501706B2/en"}, "pub_date": null, "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description_translated_from:218", "units": null, "verbatim_quote": "Previous attempts to overcome these problems have been through the use of various \u201cfixatives\u201d or \u201cmodulators\u201d to retard the evaporation of the more volatile fragrance ingredients present in fragrance compositions. For instance, U.S. Pat. No. 4,313,855 (Dragoco) describes the use in cosmetic compositions of 1-(2,6,6-trimethylcyclohexyl)-hexane-3-ol as an odourless fixative for increasing the perfume's intensity. U.S. Pat. No. 6,147,049 (Givaudan) discloses a perfume fixative derived from tera-hydronaphthalenese for use in a wide range of fragrance compositions. U.S. Pat. No. 6,440,400B1 (Takasago Perfumery) describes a composition using trimethylcyclohexane derivatives as perfuming-holding agents and melanin-formation inhibitors. U.S. Pat. No. 6,737,396B2 (Firmenich) describes a perfume composition formed by mixing 2-30%, relative to the weight of the composition, of a fixative, (1-ethoxyethoxy)cyclododecane, to fix or exalt the musky or aromatic-type notes. U.S. Pat. No. 7,538,081 (Takasago Perfumery) approaches the same problem of fixing a perfume and/or extending the perfume release from a fragrance composition. More particularly, said document describes the use of L-menthoxy ether derivatives as fixatives in fragrance compositions comprising at least one note selected from: floral, citrus, fruity, green, mint, herb and marine. JP Patent No. 61-083114 (Kanebo) describes ether derivatives as aroma-preserving agent for fine perfume composition. JP Patent No. 61-063612 (Kanebo) discloses diethylene glycol ether derivatives as fragrance adjusting agent showing effects as a fixative and a solubilizer. JP Patent No. 62-084010 (Shiseido) describes hydroquinone glycoside as perfume fixatives applicable for all kinds of perfume and blended perfume. On the other hand, PCT Publication No. WO85/04803 (Diagnostica) describes the use of hyaluronic acid/hyaluronate as fixatives (via molecular encapsulation) in fragrance products to improve persistence of the fragrance."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": null, "compound_ref_verbatim": null, "confidence": 0.45, "construct": {"method_text_verbatim": "The inventors have surprisingly discovered a revolutionary new way of objectively classifying fragrance materials and then formulating those fragrance materials into complex fragrance mixtures having improved fragrance profile fidelity and longevity. Essentially, the solution is to formulate the fragrance materials having low levels (10 to 30 wt % relative to the total weight of the fragrance component) of the low volatile fragrance materials in the presence of a substantially non-odorous fragrance modulator to provide for improved or enhanced longevity and/or fidelity of the fragrance profile, particularly amongst characters attributable to volatile fragrance materials. In fact, the inventors have discovered that in the complete absence of the low volatile fragrance materials or at very low levels of the low volatile fragrance materials (less than 10 wt % relative to the total weight of the fragrance component), there is insufficient character complexity and roundness of the fragrance", "panel_size": null, "property_name": "longevity", "scale": "percent", "substrate": null, "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "10 to 30", "patent_id": "US10501706B2", "provenance": {"citation": "US10501706B2", "retrieval_source": "Firecrawl scrape of Google Patents public page", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US10501706B2/en"}, "pub_date": null, "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description_translated_from:249", "units": null, "verbatim_quote": "The inventors have surprisingly discovered a revolutionary new way of objectively classifying fragrance materials and then formulating those fragrance materials into complex fragrance mixtures having improved fragrance profile fidelity and longevity. Essentially, the solution is to formulate the fragrance materials having low levels (10 to 30 wt % relative to the total weight of the fragrance component) of the low volatile fragrance materials in the presence of a substantially non-odorous fragrance modulator to provide for improved or enhanced longevity and/or fidelity of the fragrance profile, particularly amongst characters attributable to volatile fragrance materials. In fact, the inventors have discovered that in the complete absence of the low volatile fragrance materials or at very low levels of the low volatile fragrance materials (less than 10 wt % relative to the total weight of the fragrance component), there is insufficient character complexity and roundness of the fragrance profile for consumer acceptance of the composition. Therefore the level of low volatile fragrance materials needs to be carefully chosen between 10 and 30 wt % to balance consumer acceptance and the desired improved or enhanced longevity and/or fidelity of the fragrance profile, particularly amongst characters attributable to volatile fragrance materials."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": null, "compound_ref_verbatim": null, "confidence": 0.7, "construct": {"method_text_verbatim": "At the testing facility, 50 \u03bcL samples of the compositions and the controls are applied to glass slides and placed on a hot plate at 32\u00b0 C. to represent skin temperature for varying durations. It is important that glass slides of samples that are to be later compared are prepared at the same time. The panelists are asked to evaluate the perceived fragrance profile (intensity and/or character) of each glass slide sample at a given time point. Slides are presented coded so that their identity is not known by the panelists. Within a given time point panelists evaluate the slides in a random order and are able to revisit their assessment as they work through the slides at that time point. Their assessments are recorded. In the subsequent analysis, the data for strength and character comparisons are drawn from the independent assessments carried out at a given time point. Only when using the character difference scale below are any 2 products physically directly compared to each other. Pane", "panel_size": null, "property_name": "duration", "scale": "numeric_unknown", "substrate": ["skin"], "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "6 to 10", "patent_id": "US10501706B2", "provenance": {"citation": "US10501706B2", "retrieval_source": "Firecrawl scrape of Google Patents public page", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US10501706B2/en"}, "pub_date": null, "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description_translated_from:344", "units": null, "verbatim_quote": "At the testing facility, 50 \u03bcL samples of the compositions and the controls are applied to glass slides and placed on a hot plate at 32\u00b0 C. to represent skin temperature for varying durations. It is important that glass slides of samples that are to be later compared are prepared at the same time. The panelists are asked to evaluate the perceived fragrance profile (intensity and/or character) of each glass slide sample at a given time point. Slides are presented coded so that their identity is not known by the panelists. Within a given time point panelists evaluate the slides in a random order and are able to revisit their assessment as they work through the slides at that time point. Their assessments are recorded. In the subsequent analysis, the data for strength and character comparisons are drawn from the independent assessments carried out at a given time point. Only when using the character difference scale below are any 2 products physically directly compared to each other. Panelists are selected from individuals who are either trained to evaluate fragrances according to the scales below or who have experience with fragrance evaluation in the industry. Typically, around 6 to 10 panellists are used to evaluate a given product and its control."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": null, "compound_ref_verbatim": null, "confidence": 0.55, "construct": {"method_text_verbatim": "The panelists are asked to give a score on a scale of 0 to 5 for perceived fragrance intensity according to the odour intensity scale set out in Table 4 herein below.", "panel_size": null, "property_name": "fragrance_intensity", "scale": "numeric_unknown", "substrate": null, "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "0 to 5", "patent_id": "US10501706B2", "provenance": {"citation": "US10501706B2", "retrieval_source": "Firecrawl scrape of Google Patents public page", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US10501706B2/en"}, "pub_date": null, "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description_translated_from:346", "units": null, "verbatim_quote": "The panelists are asked to give a score on a scale of 0 to 5 for perceived fragrance intensity according to the odour intensity scale set out in Table 4 herein below."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": null, "compound_ref_verbatim": "example 10", "confidence": 0.9, "construct": {"method_text_verbatim": "- 1\\. The test and control compositions as described in the Example section are used for the evaluation. - 2\\. Capillaries of about 2 cm to 3.5 cm, with one sealed end are cut from a Sigma Aldrich \u201cStuart\u2122 melting point tube\u201d product code Z673269, or equivalent. A suitable fixed volume chosen between 50 and 200 \u03bcL of the composition is pipetted into the well of a VWR Tissue Culture 96 F well plate, or equivalent. The sealed end of the glass capillary is dipped into the filled well and left for at least 15 secs to wet the surface of the glass. Care must be taken not to contact the glass capillary with the sides of the well by maintaining it straight and approximately in the center of the well. - 3\\. The glass capillary is then removed from the well and inverted or transferred onto a stable surface or into a holder and allowed to evaporate at ambient conditions for a set period of time. A windshield may be used to reduce high air turbulence. - 4\\. The glass capillary is then introduced i", "panel_size": null, "property_name": "headspace_concentration_or_intensity", "scale": "hours_or_timepoint", "substrate": ["headspace"], "time_points": ["1 hr", "2 hrs", "3 hrs", "4 hrs", "5 hrs", "6 hrs"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "1 hr; 2 hrs; 3 hrs; 4 hrs; 5 hrs; 6 hrs; 50/30", "patent_id": "US10501706B2", "provenance": {"citation": "US10501706B2", "retrieval_source": "Firecrawl scrape of Google Patents public page", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US10501706B2/en"}, "pub_date": null, "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description_translated_from:368", "units": "hours", "verbatim_quote": "- 1\\. The test and control compositions as described in the Example section are used for the evaluation. - 2\\. Capillaries of about 2 cm to 3.5 cm, with one sealed end are cut from a Sigma Aldrich \u201cStuart\u2122 melting point tube\u201d product code Z673269, or equivalent. A suitable fixed volume chosen between 50 and 200 \u03bcL of the composition is pipetted into the well of a VWR Tissue Culture 96 F well plate, or equivalent. The sealed end of the glass capillary is dipped into the filled well and left for at least 15 secs to wet the surface of the glass. Care must be taken not to contact the glass capillary with the sides of the well by maintaining it straight and approximately in the center of the well. - 3\\. The glass capillary is then removed from the well and inverted or transferred onto a stable surface or into a holder and allowed to evaporate at ambient conditions for a set period of time. A windshield may be used to reduce high air turbulence. - 4\\. The glass capillary is then introduced into an empty 20 mL HS vial, which is immediately closed with a PTFE cap. The time at which this takes place is determined to be time T=initial (i.e., T=10 mins). - 5\\. Multiple glass capillaries are prepared in the same way and left to evaporate at ambient temperature for pre-determined periods of time, such as for example 10, 15, 30 mins, 1 hr, 2 hrs, 3 hrs, 4 hrs, 5 hrs, and up to 6 hrs, before being introduced to the headspace vial and sealed. - 6\\. The HS vial is then analysed on an Agilent GC system 6890 equipped with a Gerstel MPS 2 autosampler, or equivalent, capable of performing SPME injections. A SPME fiber assembly DVB/CAR/PDMS (50/30 \u03bcm, 1 cm length) is required. A GC column such as a DB-5MS, ZB-5MSi models, or equivalent phase, with a length of 30 m, an inner diameter of 0.25 mm and a film thickness of 1 \u03bcm is used. - 7\\. The SPME HS parameters are set to the values indicated as follows:"}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": null, "compound_ref_verbatim": null, "confidence": 0.7, "construct": {"method_text_verbatim": "Compositions disclosed in Tables 18(a) and 19(a)-19(b) are applied to glass slides in accordance with the protocol described in the Method Section and a panel of around 6-10 experienced panelists evaluate the perceived fragrance profile at initial time 0, then at various time points, typically 1 hour, 2 hours, 3 hours, 4 hours and 6 hours post application. Panelists are asked to score the compositions for the longevity of the fragrance profile on a scale of 0 to 5, wherein 0 represents a no fragrance is detected and 5 represents a very strong fragrance intensity is detected; and for fragrance profile fidelity on a scale of 0 to 3 wherein 0 represents not detectable and 3 represents it being the dominant character. The results of the panelists are then averaged and discussed below.", "panel_size": null, "property_name": "fragrance_intensity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["1 hour", "2 hours", "3 hours", "4 hours", "6 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "6-10; 1 hour; 2 hours; 3 hours; 4 hours; 6 hours; 0 to 5; 0 to 3", "patent_id": "US10501706B2", "provenance": {"citation": "US10501706B2", "retrieval_source": "Firecrawl scrape of Google Patents public page", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US10501706B2/en"}, "pub_date": null, "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description_translated_from:474", "units": "hours", "verbatim_quote": "Compositions disclosed in Tables 18(a) and 19(a)-19(b) are applied to glass slides in accordance with the protocol described in the Method Section and a panel of around 6-10 experienced panelists evaluate the perceived fragrance profile at initial time 0, then at various time points, typically 1 hour, 2 hours, 3 hours, 4 hours and 6 hours post application. Panelists are asked to score the compositions for the longevity of the fragrance profile on a scale of 0 to 5, wherein 0 represents a no fragrance is detected and 5 represents a very strong fragrance intensity is detected; and for fragrance profile fidelity on a scale of 0 to 3 wherein 0 represents not detectable and 3 represents it being the dominant character. The results of the panelists are then averaged and discussed below."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": null, "compound_ref_verbatim": null, "confidence": 0.7, "construct": {"method_text_verbatim": "FIG. 1 shows the fragrance intensity profile of Composition R as evaluated by 10 panelists, which comprises the substantially non-odorous fragrance modulator sucrose myristate and the single fragrance material, ethyl safranate. Addition of the substantially non-odorous fragrance modulator maintains the intensity of the fragrance material for up to 6 hours whilst the control, Composition S, in the absence of the substantially non-odorous fragrance modulator, drops in fragrance intensity profile over the 6 hours. The substantially non-odorous fragrance modulator acts to maintain the continued evaporation over time of the fragrance material. Statistical analysis using the Tukey correction for multiple comparisons confirms the statistically significant difference at 0 hours (p=0.0015), 1 hour (p=0.0033), 3 hours (p=0.0015) and 6 hours ((p=0.0152) all at 95% significance level (i.e., p<0.05).", "panel_size": 10, "property_name": "fragrance_intensity", "scale": "percent", "substrate": null, "time_points": ["6 hours", "0 hours", "1 hour", "3 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "6 hours; 0 hours; 1 hour; 3 hours", "patent_id": "US10501706B2", "provenance": {"citation": "US10501706B2", "retrieval_source": "Firecrawl scrape of Google Patents public page", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US10501706B2/en"}, "pub_date": null, "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description_translated_from:476", "units": "hours", "verbatim_quote": "FIG. 1 shows the fragrance intensity profile of Composition R as evaluated by 10 panelists, which comprises the substantially non-odorous fragrance modulator sucrose myristate and the single fragrance material, ethyl safranate. Addition of the substantially non-odorous fragrance modulator maintains the intensity of the fragrance material for up to 6 hours whilst the control, Composition S, in the absence of the substantially non-odorous fragrance modulator, drops in fragrance intensity profile over the 6 hours. The substantially non-odorous fragrance modulator acts to maintain the continued evaporation over time of the fragrance material. Statistical analysis using the Tukey correction for multiple comparisons confirms the statistically significant difference at 0 hours (p=0.0015), 1 hour (p=0.0033), 3 hours (p=0.0015) and 6 hours ((p=0.0152) all at 95% significance level (i.e., p<0.05)."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": null, "compound_ref_verbatim": null, "confidence": 0.7, "construct": {"method_text_verbatim": "FIG. 2 shows the fragrance intensity profile of Composition P as evaluated by 10 panellists, which comprises the substantially non-odorous fragrance modulator sucrose myristate and the single fragrance material, Dimethylbenzyl carbinol. Addition of the substantially non-odorous fragrance modulator maintains the intensity of the fragrance material for up to 6 hours whilst the control, Composition Q, in the absence of the substantially non-odorous fragrance modulator, drops in fragrance intensity profile over the 6 hours. The substantially non-odorous fragrance modulator acts to maintain the continued evaporation over time of the fragrance material. Statistical analysis using the Tukey correction for multiple comparisons confirms the statistically significant difference at 1 hour (p=0.0581) at 90% significance level (i.e., p<0.1), 3 hours (p=0.0311) at 95% significance level (i.e., p<0.05).", "panel_size": null, "property_name": "fragrance_intensity", "scale": "percent", "substrate": null, "time_points": ["6 hours", "1 hour", "3 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "6 hours; 1 hour; 3 hours", "patent_id": "US10501706B2", "provenance": {"citation": "US10501706B2", "retrieval_source": "Firecrawl scrape of Google Patents public page", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US10501706B2/en"}, "pub_date": null, "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description_translated_from:477", "units": "hours", "verbatim_quote": "FIG. 2 shows the fragrance intensity profile of Composition P as evaluated by 10 panellists, which comprises the substantially non-odorous fragrance modulator sucrose myristate and the single fragrance material, Dimethylbenzyl carbinol. Addition of the substantially non-odorous fragrance modulator maintains the intensity of the fragrance material for up to 6 hours whilst the control, Composition Q, in the absence of the substantially non-odorous fragrance modulator, drops in fragrance intensity profile over the 6 hours. The substantially non-odorous fragrance modulator acts to maintain the continued evaporation over time of the fragrance material. Statistical analysis using the Tukey correction for multiple comparisons confirms the statistically significant difference at 1 hour (p=0.0581) at 90% significance level (i.e., p<0.1), 3 hours (p=0.0311) at 95% significance level (i.e., p<0.05)."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": null, "compound_ref_verbatim": null, "confidence": 0.7, "construct": {"method_text_verbatim": "FIG. 3 shows the fragrance intensity profile of Composition T as evaluated by 10 panelists, which comprises the substantially non-odorous fragrance modulator sucrose myristate and the single fragrance material phenethyl alcohol (PEA). Addition of the substantially non-odorous fragrance modulator maintains the intensity of the fragrance material for up to 6 hours whilst the control, Composition U, in the absence of the substantially non-odorous fragrance modulator, drops in fragrance intensity profile over the 6 hours. The substantially non-odorous fragrance modulator acts to maintain the continued evaporation over time of the fragrance material. Statistical analysis using the Tukey correction for multiple comparisons confirms the statistically significant difference at 1 hour (p<0.0001), 3 hours (p=0.0016) and 6 hours (p=0.0003) all at 95% significance level (i.e., p<0.05).", "panel_size": 10, "property_name": "fragrance_intensity", "scale": "percent", "substrate": null, "time_points": ["6 hours", "1 hour", "3 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "6 hours; 1 hour; 3 hours", "patent_id": "US10501706B2", "provenance": {"citation": "US10501706B2", "retrieval_source": "Firecrawl scrape of Google Patents public page", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US10501706B2/en"}, "pub_date": null, "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description_translated_from:478", "units": "hours", "verbatim_quote": "FIG. 3 shows the fragrance intensity profile of Composition T as evaluated by 10 panelists, which comprises the substantially non-odorous fragrance modulator sucrose myristate and the single fragrance material phenethyl alcohol (PEA). Addition of the substantially non-odorous fragrance modulator maintains the intensity of the fragrance material for up to 6 hours whilst the control, Composition U, in the absence of the substantially non-odorous fragrance modulator, drops in fragrance intensity profile over the 6 hours. The substantially non-odorous fragrance modulator acts to maintain the continued evaporation over time of the fragrance material. Statistical analysis using the Tukey correction for multiple comparisons confirms the statistically significant difference at 1 hour (p<0.0001), 3 hours (p=0.0016) and 6 hours (p=0.0003) all at 95% significance level (i.e., p<0.05)."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": null, "compound_ref_verbatim": null, "confidence": 0.7, "construct": {"method_text_verbatim": "FIG. 4 shows the fragrance intensity profile of Composition ZZ as evaluated by 11 panelists, which comprises the substantially non-odorous fragrance modulator hydroquinone beta-D-glycoside and the single fragrance material, eugenol. Addition of the substantially non-odorous modulator maintains the intensity of the fragrance material for up to 6 hours whilst the control, Composition ZZZ, in the absence of the substantially non-odorous fragrance modulator, drops in fragrance intensity profile over the 6 hours. The substantially non-odorous fragrance modulator acts to maintain the continued evaporation over time of the fragrance material. Statistical analysis using the Tukey correction for multiple comparisons confirms the statistically significant difference at 1 hour (p=0.0008) and 3 hours (p=0.0123) all at 95% significance level (i.e., p<0.05).", "panel_size": 11, "property_name": "fragrance_intensity", "scale": "percent", "substrate": null, "time_points": ["6 hours", "1 hour", "3 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "6 hours; 1 hour; 3 hours", "patent_id": "US10501706B2", "provenance": {"citation": "US10501706B2", "retrieval_source": "Firecrawl scrape of Google Patents public page", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US10501706B2/en"}, "pub_date": null, "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description_translated_from:479", "units": "hours", "verbatim_quote": "FIG. 4 shows the fragrance intensity profile of Composition ZZ as evaluated by 11 panelists, which comprises the substantially non-odorous fragrance modulator hydroquinone beta-D-glycoside and the single fragrance material, eugenol. Addition of the substantially non-odorous modulator maintains the intensity of the fragrance material for up to 6 hours whilst the control, Composition ZZZ, in the absence of the substantially non-odorous fragrance modulator, drops in fragrance intensity profile over the 6 hours. The substantially non-odorous fragrance modulator acts to maintain the continued evaporation over time of the fragrance material. Statistical analysis using the Tukey correction for multiple comparisons confirms the statistically significant difference at 1 hour (p=0.0008) and 3 hours (p=0.0123) all at 95% significance level (i.e., p<0.05)."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": null, "compound_ref_verbatim": null, "confidence": 0.45, "construct": {"method_text_verbatim": "(b) Effects of the Substantially Non-Odorous Fragrance Modulators on the Fragrance Profile Longevity of Compositions Having Reduced Levels of Low Volatile Fragrance Materials (Between 10 to 30 wt % Relative to the Total Weight of the Fragrance Component) Vs. Compositions Having Traditional Levels of Low Volatile Fragrance Materials (Greater than 30 wt Relative to the Total Weight of the Fragrance Component) and No Substantially Non-Odorous Fragrance Modulator", "panel_size": null, "property_name": "longevity", "scale": "percent", "substrate": null, "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "10 to 30", "patent_id": "US10501706B2", "provenance": {"citation": "US10501706B2", "retrieval_source": "Firecrawl scrape of Google Patents public page", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US10501706B2/en"}, "pub_date": null, "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description_translated_from:480", "units": null, "verbatim_quote": "(b) Effects of the Substantially Non-Odorous Fragrance Modulators on the Fragrance Profile Longevity of Compositions Having Reduced Levels of Low Volatile Fragrance Materials (Between 10 to 30 wt % Relative to the Total Weight of the Fragrance Component) Vs. Compositions Having Traditional Levels of Low Volatile Fragrance Materials (Greater than 30 wt Relative to the Total Weight of the Fragrance Component) and No Substantially Non-Odorous Fragrance Modulator"}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": null, "compound_ref_verbatim": null, "confidence": 0.55, "construct": {"method_text_verbatim": "Panelists are asked to score the compositions for the intensity of the fragrance on a scale of 0 to 5, wherein 0 represents no fragrance intensity is detected and 5 represents a very strong fragrance intensity is detected. The results of the panel test are then averaged. The results show the effect of the substantially non-odorous fragrance modulator and reduced levels of low volatile fragrance materials for any one of the inventive Compositions A, D, G, J and M on fragrance profile longevity versus control Compositions C, F, I, L and O in the absence of a substantially non-odorous modulator. Alternatively, the results show the effect of the substantially non-odorous fragrance modulator and reduced levels of low volatile fragrance materials for any one of the inventive Compositions A, D, G, J and M on fragrance profile longevity versus traditional Compositions B, E, H, K and N in the presence of the substantially non-odorous fragrance modulator.", "panel_size": null, "property_name": "fragrance_intensity", "scale": "hours_or_timepoint", "substrate": null, "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "0 to 5", "patent_id": "US10501706B2", "provenance": {"citation": "US10501706B2", "retrieval_source": "Firecrawl scrape of Google Patents public page", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US10501706B2/en"}, "pub_date": null, "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description_translated_from:481", "units": null, "verbatim_quote": "Panelists are asked to score the compositions for the intensity of the fragrance on a scale of 0 to 5, wherein 0 represents no fragrance intensity is detected and 5 represents a very strong fragrance intensity is detected. The results of the panel test are then averaged. The results show the effect of the substantially non-odorous fragrance modulator and reduced levels of low volatile fragrance materials for any one of the inventive Compositions A, D, G, J and M on fragrance profile longevity versus control Compositions C, F, I, L and O in the absence of a substantially non-odorous modulator. Alternatively, the results show the effect of the substantially non-odorous fragrance modulator and reduced levels of low volatile fragrance materials for any one of the inventive Compositions A, D, G, J and M on fragrance profile longevity versus traditional Compositions B, E, H, K and N in the presence of the substantially non-odorous fragrance modulator."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": null, "compound_ref_verbatim": null, "confidence": 0.6, "construct": {"method_text_verbatim": "Fragrance profile longevity, is maintained for up to at least 6 hours in the presence of the substantially non-odorous fragrance modulator whilst it drops in the absence of the substantially non-odorous fragrance modulator (data not shown). Without wishing to be bound by theory, it is believed that the substantially non-odorous fragrance modulator acts to maintain the continued evaporation over time of the fragrance materials, particular the volatile fragrance materials. The effect of the improved fragrance profile longevity of the present invention are noticeable at 1, 3 and 6 hours.", "panel_size": null, "property_name": "longevity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["6 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "6 hours", "patent_id": "US10501706B2", "provenance": {"citation": "US10501706B2", "retrieval_source": "Firecrawl scrape of Google Patents public page", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US10501706B2/en"}, "pub_date": null, "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description_translated_from:482", "units": "hours", "verbatim_quote": "Fragrance profile longevity, is maintained for up to at least 6 hours in the presence of the substantially non-odorous fragrance modulator whilst it drops in the absence of the substantially non-odorous fragrance modulator (data not shown). Without wishing to be bound by theory, it is believed that the substantially non-odorous fragrance modulator acts to maintain the continued evaporation over time of the fragrance materials, particular the volatile fragrance materials. The effect of the improved fragrance profile longevity of the present invention are noticeable at 1, 3 and 6 hours."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": null, "compound_ref_verbatim": null, "confidence": 0.6, "construct": {"method_text_verbatim": "The test demonstrates the character retention over time of a fragrance composition. The results show the effect of the substantially non-odorous fragrance modulator and reduced levels of low volatile fragrance materials for any one of the inventive Compositions A, D, G, J, and M on fragrance profile longevity versus control Compositions C, F, I, L, and O, in the absence of the substantially non-odorous modulator. Alternatively, results show the effect of the substantially non-odorous fragrance modulator and reduced levels of low volatile fragrance materials for any one of the inventive Compositions A, D, G, J, and M on fragrance profile longevity versus traditional Compositions B, E, H, K, and N, in the presence of the substantially non-odorous fragrance modulator. Fragrance profile fidelity, particularly characters attributable to the volatile fragrance materials are maintained for up to at least 1 hour in the presence of the substantially non-odorous fragrance modulator whilst they d", "panel_size": null, "property_name": "longevity", "scale": "hours_or_timepoint", "substrate": null, "time_points": ["1 hour"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "1 hour", "patent_id": "US10501706B2", "provenance": {"citation": "US10501706B2", "retrieval_source": "Firecrawl scrape of Google Patents public page", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US10501706B2/en"}, "pub_date": null, "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description_translated_from:499", "units": "hours", "verbatim_quote": "The test demonstrates the character retention over time of a fragrance composition. The results show the effect of the substantially non-odorous fragrance modulator and reduced levels of low volatile fragrance materials for any one of the inventive Compositions A, D, G, J, and M on fragrance profile longevity versus control Compositions C, F, I, L, and O, in the absence of the substantially non-odorous modulator. Alternatively, results show the effect of the substantially non-odorous fragrance modulator and reduced levels of low volatile fragrance materials for any one of the inventive Compositions A, D, G, J, and M on fragrance profile longevity versus traditional Compositions B, E, H, K, and N, in the presence of the substantially non-odorous fragrance modulator. Fragrance profile fidelity, particularly characters attributable to the volatile fragrance materials are maintained for up to at least 1 hour in the presence of the substantially non-odorous fragrance modulator whilst they drop in the absence of the substantially non-odorous fragrance modulator."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": null, "compound_ref_verbatim": null, "confidence": 0.45, "construct": {"method_text_verbatim": "- a.) Matrix Systems: The fragrance is dissolved or dispersed in a polymer matrix or particle. Perfumes, for example, may be 1) dispersed into the polymer prior to formulating into the product or 2) added separately from the polymer during or after formulation of the product. Diffusion of perfume from the polymer is a common trigger that allows or increases the rate of perfume release from a polymeric matrix system that is deposited or applied to the desired surface (situs), although many other triggers are know that may control perfume release. Absorption and/or adsorption into or onto polymeric particles, films, solutions, and the like are aspects of this technology. Nano- or micro-particles composed of organic materials (e.g., latexes) are examples. Suitable particles include a wide range of materials including, but not limited to polyacetal, polyacrylate, polyacrylic, polyacrylonitrile, polyamide, polyaryletherketone, polybutadiene, polybutylene, polybutylene terephthalate, polychl", "panel_size": null, "property_name": "odor_intensity", "scale": "numeric_unknown", "substrate": null, "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "2005/0003980; 2004/0110648; 2006/003913", "patent_id": "US20190070086A1", "provenance": {"citation": "US20190070086A1", "retrieval_source": "Firecrawl scrape of Google Patents public page", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20190070086A1/en"}, "pub_date": null, "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description_translated_from:520", "units": "ordinal_ratio", "verbatim_quote": "- a.) Matrix Systems: The fragrance is dissolved or dispersed in a polymer matrix or particle. Perfumes, for example, may be 1) dispersed into the polymer prior to formulating into the product or 2) added separately from the polymer during or after formulation of the product. Diffusion of perfume from the polymer is a common trigger that allows or increases the rate of perfume release from a polymeric matrix system that is deposited or applied to the desired surface (situs), although many other triggers are know that may control perfume release. Absorption and/or adsorption into or onto polymeric particles, films, solutions, and the like are aspects of this technology. Nano- or micro-particles composed of organic materials (e.g., latexes) are examples. Suitable particles include a wide range of materials including, but not limited to polyacetal, polyacrylate, polyacrylic, polyacrylonitrile, polyamide, polyaryletherketone, polybutadiene, polybutylene, polybutylene terephthalate, polychloroprene, poly ethylene, polyethylene terephthalate, polycyclohexylene dimethylene terephthalate, polycarbonate, polychloroprene, polyhydroxyalkanoate, polyketone, polyester, polyethylene, polyetherimide, polyethersulfone, polyethylenechlorinates, polyimide, polyisoprene, polylactic acid, polymethylpentene, polyphenylene oxide, polyphenylene sulfide, polyphthalamide, polypropylene, polystyrene, polysulfone, polyvinyl acetate, polyvinyl chloride, as well as polymers or copolymers based on acrylonitrile-butadiene, cellulose acetate, ethylene-vinyl acetate, ethylene vinyl alcohol, styrene-butadiene, vinyl acetate-ethylene, and mixtures thereof. - \u201cStandard\u201d systems refer to those that are \u201cpre-loaded\u201d with the intent of keeping the pre-loaded perfume associated with the polymer until the moment or moments of perfume release. Such polymers may also suppress the neat product odor and provide a bloom and/or longevity benefit depending on the rate of perfume release. One challenge with such systems is to achieve the ideal balance between 1) in-product stability (keeping perfume inside carrier until you need it) and 2) timely release (during use or from dry situs). Achieving such stability is particularly important during in-product storage and product aging. This challenge is particularly apparent for aqueous-based, surfactant-containing products, such as heavy duty liquid laundry detergents. Many \u201cStandard\u201d matrix systems available effectively become \u201cEquilibrium\u201d systems when formulated into aqueous-based products. One may select an \u201cEquilibrium\u201d system or a Reservoir system, which has acceptable in-product diffusion stability and available triggers for release (e.g., friction). \u201cEquilibrium\u201d systems are those in which the perfume and polymer may be added separately to the product, and the equilibrium interaction between perfume and polymer leads to a benefit at one or more consumer touch points (versus a free perfume control that has no polymer-assisted delivery technology). The polymer may also be pre-loaded with perfume; however, part or all of the perfume may diffuse during in-product storage reaching an equilibrium that includes having desired perfume raw materials (PRMs) associated with the polymer. The polymer then carries the perfume to the surface, and release is typically via perfume diffusion. The use of such equilibrium system polymers has the potential to decrease the neat product odor intensity of the neat product (usually more so in the case of pre-loaded standard system). Deposition of such polymers may serve to \u201cflatten\u201d the release profile and provide increased longevity. As indicated above, such longevity would be achieved by suppressing the initial intensity and may enable the formulator to use more high impact or low odor detection threshold (ODT) or low Kovats Index (KI) PRMs to achieve FMOT benefits without initial intensity that is too strong or distorted. It is important that perfume release occurs within the time frame of the application to impact the desired consumer touch point or touch points. Suitable micro-particles and micro-latexes as well as methods of making same may be found in USPA 2005/0003980 A1. Matrix systems also include hot melt adhesives and perfume plastics. In addition, hydrophobically modified polysaccharides may be formulated into the perfumed product to increase perfume deposition and/or modify perfume release. All such matrix systems, including for example polysaccharides and nanolatexes may be combined with other PDTs, including other PAD systems such as PAD reservoir systems in the form of a perfume microcapsule (PMC). Polymer Assisted Delivery (PAD) matrix systems may include those described in the following references: US Patent Application 2004/0110648 A1 and U.S. Pat. No. 6,531,444. - Silicones are also examples of polymers that may be used as PDT, and can provide perfume benefits in a manner similar to the polymer-assisted delivery \u201cmatrix system\u201d. Such a PDT is referred to as silicone-assisted delivery (SAD). One may pre-load silicones with perfume, or use them as an equilibrium system as described for PAD. Suitable silicones as well as making same may be found in USPA 20050143282A1. Functionalized silicones may also be used as described in USPA 2006/003913 A1. Examples of silicones include polydimethylsiloxane and polyalkyldimethylsiloxanes. Other examples include those with amine functionality, which may be used to provide benefits associated with amine-assisted delivery (AAD) and/or polymer-assisted delivery (PAD) and/or amine-reaction products (ARP). Other such examples may be found in USPA 2005/0003980 A1. - b.) Reservoir Systems: Reservoir systems are also known as a core-shell type technology, or one in which the fragrance is surrounded by a perfume release controlling membrane, which may serve as a protective shell. The material inside the microcapsule is referred to as the core, internal phase, or fill, whereas the wall is sometimes called a shell, coating, or membrane. Microparticles or pressure sensitive capsules or microcapsules are examples of this technology. Microcapsules of the current invention are formed by a variety of procedures that include, but are not limited to, coating, extrusion, spray-drying, interfacial, in-situ and matrix polymerization. The possible shell materials vary widely in their stability toward water. Among the most stable are polyoxymethyleneurea (PMU)-based materials, which may hold certain PRMs for even long periods of time in aqueous solution (or product). Such systems include but are not limited to urea-formaldehyde and/or melamine-formaldehyde. Gelatin-based microcapsules may be prepared so that they dissolve quickly or slowly in water, depending for example on the degree of cross-linking. Many other capsule wall materials are available and vary in the degree of perfume diffusion stability observed. Without wishing to be bound by theory, the rate of release of perfume from a capsule, for example, once deposited on a surface is typically in reverse order of in-product perfume diffusion stability. As such, urea-formaldehyde and melamine-formaldehyde microcapsules for example, typically require a release mechanism other than, or in addition to, diffusion for release, such as mechanical force (e.g., friction, pressure, shear stress) that serves to break the capsule and increase the rate of perfume (fragrance) release. Other triggers include melting, dissolution, hydrolysis or other chemical reaction, electromagnetic radiation, and the like. Suitable capsule wall materials include, in addition to aminoplasts, polyvinyl alcohol, polyvinyl pyrrolidone, polyethylene glycol, polysaccharides and modified polysaccharides, gel forming proteins, modified celluloses such as carboxymethylcelluloses and hydroxyethylcelluloses, polyacrylates, polyureas, polyurethanes and mixtures thereof. The capsules may be further coated with an additional coating that can improve the deposition and/or retention of the capsule on the desired surface. Suitable coating materials include a cationic polymer selected from the group consisting of selected from the group consisting of polysaccharides, cationically modified starch, cationically modified guar, polysiloxanes, poly diallyl dimethyl ammonium halides, copolymers of poly diallyl dimethyl ammonium chloride and vinyl pyrrolidone, acrylamides, imidazoles, imidazolinium halides, imidazolium halides, poly vinyl amine, copolymers of poly vinyl amine and N-vinyl formamide to the surface of the capsule to form a cationically coated polymer encapsulated material. Typical capsules have a diameter of 1 micron to 500 microns. The use of pre-loaded microcapsules requires the proper ratio of in-product stability and in-use and/or on-surface (on-situs) release, as well as proper selection of PRMs. Microcapsules that are based on urea-formaldehyde and/or melamine-formaldehyde are relatively stable, especially in near neutral aqueous-based solutions. These materials may require a friction trigger which may not be applicable to all product applications. Other microcapsule materials (e.g., gelatin) may be unstable in aqueous-based products and may even provide reduced benefit (versus free perfume control) when in-product aged."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": null, "compound_ref_verbatim": null, "confidence": 0.45, "construct": {"method_text_verbatim": "This technology refers to perfume technologies that result from the reaction of perfume materials with other substrates or chemicals to form materials that have a covalent bond between one or more PRMs and one or more carriers. The PRM is converted into a new material called a pro-PRM (i.e., pro-perfume), which then may release the original PRM upon exposure to a trigger such as water or light. Pro-perfumes may provide enhanced perfume delivery properties such as increased perfume deposition, longevity, stability, retention, and the like. Pro-perfumes include those that are monomeric (non-polymeric) or polymeric, and may be pre-formed or may be formed in-situ under equilibrium conditions, such as those that may be present during in-product storage or on the wet or dry situs. Nonlimiting examples of pro-perfumes include Michael adducts (e.g., beta-amino ketones), aromatic or non-aromatic imines (Schiffs Bases), oxazolidines, beta-keto esters, and orthoesters. Another aspect includes com", "panel_size": null, "property_name": "longevity", "scale": "numeric_unknown", "substrate": null, "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "2006/0020459", "patent_id": "US20190070086A1", "provenance": {"citation": "US20190070086A1", "retrieval_source": "Firecrawl scrape of Google Patents public page", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20190070086A1/en"}, "pub_date": null, "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description_translated_from:534", "units": "ordinal_ratio", "verbatim_quote": "This technology refers to perfume technologies that result from the reaction of perfume materials with other substrates or chemicals to form materials that have a covalent bond between one or more PRMs and one or more carriers. The PRM is converted into a new material called a pro-PRM (i.e., pro-perfume), which then may release the original PRM upon exposure to a trigger such as water or light. Pro-perfumes may provide enhanced perfume delivery properties such as increased perfume deposition, longevity, stability, retention, and the like. Pro-perfumes include those that are monomeric (non-polymeric) or polymeric, and may be pre-formed or may be formed in-situ under equilibrium conditions, such as those that may be present during in-product storage or on the wet or dry situs. Nonlimiting examples of pro-perfumes include Michael adducts (e.g., beta-amino ketones), aromatic or non-aromatic imines (Schiffs Bases), oxazolidines, beta-keto esters, and orthoesters. Another aspect includes compounds comprising one or more beta-oxy or beta-thio carbonyl moieties capable of releasing a PRM, for example, an alpha, beta-unsaturated ketone, aldehyde or carboxylic ester. The typical trigger for perfume release is exposure to water; although other triggers may include enzymes, heat, light, pH change, autoxidation, a shift of equilibrium, change in concentration or ionic strength and others. For aqueous-based products, light-triggered pro-perfumes are particularly suited. Such photo-pro-perfumes (PPPs) include but are not limited to those that release coumarin derivatives and perfumes and/or pro-perfumes upon being triggered. The released pro-perfume may release one or more PRMs by means of any of the above mentioned triggers. In one aspect, the photo-pro-perfume releases a nitrogen-based pro-perfume when exposed to a light and/or moisture trigger. In another aspect, the nitrogen-based pro-perfume, released from the photo-pro-perfume, releases one or more PRMs selected, for example, from aldehydes, ketones (including enones) and alcohols. In still another aspect, the PPP releases a dihydroxy coumarin derivative. The light-triggered pro-perfume may also be an ester that releases a coumarin derivative and a perfume alcohol. In one aspect the pro-perfume is a dimethoxybenzoin derivative as described in USPA 2006/0020459 A1. In another aspect the pro-perfume is a 3\u2032,5\u2032-dimethoxybenzoin (DMB) derivative that releases an alcohol upon exposure to electromagnetic radiation. In yet another aspect, the pro-perfume releases one or more low ODT PRMs, including tertiary alcohols such as linalool, tetrahydrolinalool, or dihydromyrcenol. Suitable pro-perfumes and methods of making same can be found in U.S. Pat. No. 7,018,978 B2."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": null, "compound_ref_verbatim": null, "confidence": 0.45, "construct": {"method_text_verbatim": "- a.) Matrix Systems: The fragrance is dissolved or dispersed in a polymer matrix or particle. Perfumes, for example, may be 1) dispersed into the polymer prior to formulating into the product or 2) added separately from the polymer during or after formulation of the product. Diffusion of perfume from the polymer is a common trigger that allows or increases the rate of perfume release from a polymeric matrix system that is deposited or applied to the desired surface (situs), although many other triggers are know that may control perfume release. Absorption and/or adsorption into or onto polymeric particles, films, solutions, and the like are aspects of this technology. Nano- or micro-particles composed of organic materials (e.g., latexes) are examples. Suitable particles include a wide range of materials including, but not limited to polyacetal, polyacrylate, polyacrylic, polyacrylonitrile, polyamide, polyaryletherketone, polybutadiene, polybutylene, polybutylene terephthalate, polychl", "panel_size": null, "property_name": "odor_intensity", "scale": "numeric_unknown", "substrate": null, "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "2005/0003980; 2004/0110648; 2006/003913", "patent_id": "US20170233679A1", "provenance": {"citation": "US20170233679A1", "retrieval_source": "Firecrawl scrape of Google Patents public page", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20170233679A1/en"}, "pub_date": null, "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description_translated_from:528", "units": "ordinal_ratio", "verbatim_quote": "- a.) Matrix Systems: The fragrance is dissolved or dispersed in a polymer matrix or particle. Perfumes, for example, may be 1) dispersed into the polymer prior to formulating into the product or 2) added separately from the polymer during or after formulation of the product. Diffusion of perfume from the polymer is a common trigger that allows or increases the rate of perfume release from a polymeric matrix system that is deposited or applied to the desired surface (situs), although many other triggers are know that may control perfume release. Absorption and/or adsorption into or onto polymeric particles, films, solutions, and the like are aspects of this technology. Nano- or micro-particles composed of organic materials (e.g., latexes) are examples. Suitable particles include a wide range of materials including, but not limited to polyacetal, polyacrylate, polyacrylic, polyacrylonitrile, polyamide, polyaryletherketone, polybutadiene, polybutylene, polybutylene terephthalate, polychloroprene, poly ethylene, polyethylene terephthalate, polycyclohexylene dimethylene terephthalate, polycarbonate, polychloroprene, polyhydroxyalkanoate, polyketone, polyester, polyethylene, polyetherimide, polyethersulfone, polyethylenechlorinates, polyimide, polyisoprene, polylactic acid, polymethylpentene, polyphenylene oxide, polyphenylene sulfide, polyphthalamide, polypropylene, polystyrene, polysulfone, polyvinyl acetate, polyvinyl chloride, as well as polymers or copolymers based on acrylonitrile-butadiene, cellulose acetate, ethylene-vinyl acetate, ethylene vinyl alcohol, styrene-butadiene, vinyl acetate-ethylene, and mixtures thereof. - \u201cStandard\u201d systems refer to those that are \u201cpre-loaded\u201d with the intent of keeping the pre-loaded perfume associated with the polymer until the moment or moments of perfume release. Such polymers may also suppress the neat product odor and provide a bloom and/or longevity benefit depending on the rate of perfume release. One challenge with such systems is to achieve the ideal balance between 1) in-product stability (keeping perfume inside carrier until you need it) and 2) timely release (during use or from dry situs). Achieving such stability is particularly important during in-product storage and product aging. This challenge is particularly apparent for aqueous-based, surfactant-containing products, such as heavy duty liquid laundry detergents. Many \u201cStandard\u201d matrix systems available effectively become \u201cEquilibrium\u201d systems when formulated into aqueous-based products. One may select an \u201cEquilibrium\u201d system or a Reservoir system, which has acceptable in-product diffusion stability and available triggers for release (e.g., friction). \u201cEquilibrium\u201d systems are those in which the perfume and polymer may be added separately to the product, and the equilibrium interaction between perfume and polymer leads to a benefit at one or more consumer touch points (versus a free perfume control that has no polymer-assisted delivery technology). The polymer may also be pre-loaded with perfume; however, part or all of the perfume may diffuse during in-product storage reaching an equilibrium that includes having desired perfume raw materials (PRMs) associated with the polymer. The polymer then carries the perfume to the surface, and release is typically via perfume diffusion. The use of such equilibrium system polymers has the potential to decrease the neat product odor intensity of the neat product (usually more so in the case of pre-loaded standard system). Deposition of such polymers may serve to \u201cflatten\u201d the release profile and provide increased longevity. As indicated above, such longevity would be achieved by suppressing the initial intensity and may enable the formulator to use more high impact or low odor detection threshold (ODT) or low Kovats Index (KI) PRMs to achieve FMOT benefits without initial intensity that is too strong or distorted. It is important that perfume release occurs within the time frame of the application to impact the desired consumer touch point or touch points. Suitable micro-particles and micro-latexes as well as methods of making same may be found in USPA 2005/0003980 A1. Matrix systems also include hot melt adhesives and perfume plastics. In addition, hydrophobically modified polysaccharides may be formulated into the perfumed product to increase perfume deposition and/or modify perfume release. All such matrix systems, including for example polysaccharides and nanolatexes may be combined with other PDTs, including other PAD systems such as PAD reservoir systems in the form of a perfume microcapsule (PMC). Polymer Assisted Delivery (PAD) matrix systems may include those described in the following references: US Patent Application 2004/0110648 A1 and U.S. Pat. No. 6,531,444. - Silicones are also examples of polymers that may be used as PDT, and can provide perfume benefits in a manner similar to the polymer-assisted delivery \u201cmatrix system\u201d. Such a PDT is referred to as silicone-assisted delivery (SAD). One may pre-load silicones with perfume, or use them as an equilibrium system as described for PAD. Suitable silicones as well as making same may be found in USPA 20050143282A1. Functionalized silicones may also be used as described in USPA 2006/003913 A1. Examples of silicones include polydimethylsiloxane and polyalkyldimethylsiloxanes. Other examples include those with amine functionality, which may be used to provide benefits associated with amine-assisted delivery (AAD) and/or polymer-assisted delivery (PAD) and/or amine-reaction products (ARP). Other such examples may be found in USPA 2005/0003980 A1. - b.) Reservoir Systems: Reservoir systems are also known as a core-shell type technology, or one in which the fragrance is surrounded by a perfume release controlling membrane, which may serve as a protective shell. The material inside the microcapsule is referred to as the core, internal phase, or fill, whereas the wall is sometimes called a shell, coating, or membrane. Microparticles or pressure sensitive capsules or microcapsules are examples of this technology. Microcapsules of the current invention are formed by a variety of procedures that include, but are not limited to, coating, extrusion, spray-drying, interfacial, in-situ and matrix polymerization. The possible shell materials vary widely in their stability toward water. Among the most stable are polyoxymethyleneurea (PMU)-based materials, which may hold certain PRMs for even long periods of time in aqueous solution (or product). Such systems include but are not limited to urea-formaldehyde and/or melamine-formaldehyde. Gelatin-based microcapsules may be prepared so that they dissolve quickly or slowly in water, depending for example on the degree of cross-linking. Many other capsule wall materials are available and vary in the degree of perfume diffusion stability observed. Without wishing to be bound by theory, the rate of release of perfume from a capsule, for example, once deposited on a surface is typically in reverse order of in-product perfume diffusion stability. As such, urea-formaldehyde and melamine-formaldehyde microcapsules for example, typically require a release mechanism other than, or in addition to, diffusion for release, such as mechanical force (e.g., friction, pressure, shear stress) that serves to break the capsule and increase the rate of perfume (fragrance) release. Other triggers include melting, dissolution, hydrolysis or other chemical reaction, electromagnetic radiation, and the like. Suitable capsule wall materials include, in addition to aminoplasts, polyvinyl alcohol, polyvinyl pyrrolidone, polyethylene glycol, polysaccharides and modified polysaccharides, gel forming proteins, modified celluloses such as carboxymethylcelluloses and hydroxyethylcelluloses, polyacrylates, polyureas, polyurethanes and mixtures thereof. The capsules may be further coated with an additional coating that can improve the deposition and/or retention of the capsule on the desired surface. Suitable coating materials include a cationic polymer selected from the group consisting of selected from the group consisting of polysaccharides, cationically modified starch, cationically modified guar, polysiloxanes, poly diallyl dimethyl ammonium halides, copolymers of poly diallyl dimethyl ammonium chloride and vinyl pyrrolidone, acrylamides, imidazoles, imidazolinium halides, imidazolium halides, poly vinyl amine, copolymers of poly vinyl amine and N-vinyl formamide to the surface of the capsule to form a cationically coated polymer encapsulated material. Typical capsules have a diameter of 1 micron to 500 microns. The use of pre-loaded microcapsules requires the proper ratio of in-product stability and in-use and/or on-surface (on-situs) release, as well as proper selection of PRMs. Microcapsules that are based on urea-formaldehyde and/or melamine-formaldehyde are relatively stable, especially in near neutral aqueous-based solutions. These materials may require a friction trigger which may not be applicable to all product applications. Other microcapsule materials (e.g., gelatin) may be unstable in aqueous-based products and may even provide reduced benefit (versus free perfume control) when in-product aged."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": null, "compound_ref_verbatim": null, "confidence": 0.45, "construct": {"method_text_verbatim": "VIII. Pro-Perfume (PP): This technology refers to perfume technologies that result from the reaction of perfume materials with other substrates or chemicals to form materials that have a covalent bond between one or more PRMs and one or more carriers. The PRM is converted into a new material called a pro-PRM (i.e., pro-perfume), which then may release the original PRM upon exposure to a trigger such as water or light. Pro-perfumes may provide enhanced perfume delivery properties such as increased perfume deposition, longevity, stability, retention, and the like. Pro-perfumes include those that are monomeric (non-polymeric) or polymeric, and may be pre-formed or may be formed in-situ under equilibrium conditions, such as those that may be present during in-product storage or on the wet or dry situs. Nonlimiting examples of pro-perfumes include Michael adducts (e.g., beta-amino ketones), aromatic or non-aromatic imines (Schiffs Bases), oxazolidines, beta-keto esters, and orthoesters. Ano", "panel_size": null, "property_name": "longevity", "scale": "numeric_unknown", "substrate": null, "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "2006/0020459", "patent_id": "US20170233679A1", "provenance": {"citation": "US20170233679A1", "retrieval_source": "Firecrawl scrape of Google Patents public page", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20170233679A1/en"}, "pub_date": null, "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description_translated_from:535", "units": "ordinal_ratio", "verbatim_quote": "VIII. Pro-Perfume (PP): This technology refers to perfume technologies that result from the reaction of perfume materials with other substrates or chemicals to form materials that have a covalent bond between one or more PRMs and one or more carriers. The PRM is converted into a new material called a pro-PRM (i.e., pro-perfume), which then may release the original PRM upon exposure to a trigger such as water or light. Pro-perfumes may provide enhanced perfume delivery properties such as increased perfume deposition, longevity, stability, retention, and the like. Pro-perfumes include those that are monomeric (non-polymeric) or polymeric, and may be pre-formed or may be formed in-situ under equilibrium conditions, such as those that may be present during in-product storage or on the wet or dry situs. Nonlimiting examples of pro-perfumes include Michael adducts (e.g., beta-amino ketones), aromatic or non-aromatic imines (Schiffs Bases), oxazolidines, beta-keto esters, and orthoesters. Another aspect includes compounds comprising one or more beta-oxy or beta-thio carbonyl moieties capable of releasing a PRM, for example, an alpha, beta-unsaturated ketone, aldehyde or carboxylic ester. The typical trigger for perfume release is exposure to water; although other triggers may include enzymes, heat, light, pH change, autoxidation, a shift of equilibrium, change in concentration or ionic strength and others. For aqueous-based products, light-triggered pro-perfumes are particularly suited. Such photo-pro-perfumes (PPPs) include but are not limited to those that release coumarin derivatives and perfumes and/or pro-perfumes upon being triggered. The released pro-perfume may release one or more PRMs by means of any of the above mentioned triggers. In one aspect, the photo-pro-perfume releases a nitrogen-based pro-perfume when exposed to a light and/or moisture trigger. In another aspect, the nitrogen-based pro-perfume, released from the photo-pro-perfume, releases one or more PRMs selected, for example, from aldehydes, ketones (including enones) and alcohols. In still another aspect, the PPP releases a dihydroxy coumarin derivative. The light-triggered pro-perfume may also be an ester that releases a coumarin derivative and a perfume alcohol. In one aspect the pro-perfume is a dimethoxybenzoin derivative as described in USPA 2006/0020459 A1. In another aspect the pro-perfume is a 3\u2032,5\u2032-dimethoxybenzoin (DMB) derivative that releases an alcohol upon exposure to electromagnetic radiation. In yet another aspect, the pro-perfume releases one or more low ODT PRMs, including tertiary alcohols such as linalool, tetrahydrolinalool, or dihydromyrcenol. Suitable pro-perfumes and methods of making same can be found in U.S. Pat. No. 7,018,978 B2."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": null, "compound_ref_verbatim": null, "confidence": 0.45, "construct": {"method_text_verbatim": "- a.) Matrix Systems: The fragrance is dissolved or dispersed in a polymer matrix or particle. Perfumes, for example, may be 1) dispersed into the polymer prior to formulating into the product or 2) added separately from the polymer during or after formulation of the product. Diffusion of perfume from the polymer is a common trigger that allows or increases the rate of perfume release from a polymeric matrix system that is deposited or applied to the desired surface (situs), although many other triggers are know that may control perfume release. Absorption and/or adsorption into or onto polymeric particles, films, solutions, and the like are aspects of this technology. Nano- or micro-particles composed of organic materials (e.g., latexes) are examples. Suitable particles include a wide range of materials including, but not limited to polyacetal, polyacrylate, polyacrylic, polyacrylonitrile, polyamide, polyaryletherketone, polybutadiene, polybutylene, polybutylene terephthalate, polychl", "panel_size": null, "property_name": "odor_intensity", "scale": "numeric_unknown", "substrate": null, "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "2005/0003980; 2004/0110648; 2006/003913", "patent_id": "US20140170194A1", "provenance": {"citation": "US20140170194A1", "retrieval_source": "Firecrawl scrape of Google Patents public page", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20140170194A1/en"}, "pub_date": null, "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description_translated_from:533", "units": "ordinal_ratio", "verbatim_quote": "- a.) Matrix Systems: The fragrance is dissolved or dispersed in a polymer matrix or particle. Perfumes, for example, may be 1) dispersed into the polymer prior to formulating into the product or 2) added separately from the polymer during or after formulation of the product. Diffusion of perfume from the polymer is a common trigger that allows or increases the rate of perfume release from a polymeric matrix system that is deposited or applied to the desired surface (situs), although many other triggers are know that may control perfume release. Absorption and/or adsorption into or onto polymeric particles, films, solutions, and the like are aspects of this technology. Nano- or micro-particles composed of organic materials (e.g., latexes) are examples. Suitable particles include a wide range of materials including, but not limited to polyacetal, polyacrylate, polyacrylic, polyacrylonitrile, polyamide, polyaryletherketone, polybutadiene, polybutylene, polybutylene terephthalate, polychloroprene, poly ethylene, polyethylene terephthalate, polycyclohexylene dimethylene terephthalate, polycarbonate, polychloroprene, polyhydroxyalkanoate, polyketone, polyester, polyethylene, polyetherimide, polyethersulfone, polyethylenechlorinates, polyimide, polyisoprene, polylactic acid, polymethylpentene, polyphenylene oxide, polyphenylene sulfide, polyphthalamide, polypropylene, polystyrene, polysulfone, polyvinyl acetate, polyvinyl chloride, as well as polymers or copolymers based on acrylonitrile-butadiene, cellulose acetate, ethylene-vinyl acetate, ethylene vinyl alcohol, styrene-butadiene, vinyl acetate-ethylene, and mixtures thereof. - \u201cStandard\u201d systems refer to those that are \u201cpre-loaded\u201d with the intent of keeping the pre-loaded perfume associated with the polymer until the moment or moments of perfume release. Such polymers may also suppress the neat product odor and provide a bloom and/or longevity benefit depending on the rate of perfume release. One challenge with such systems is to achieve the ideal balance between 1) in-product stability (keeping perfume inside carrier until you need it) and 2) timely release (during use or from dry situs). Achieving such stability is particularly important during in-product storage and product aging. This challenge is particularly apparent for aqueous-based, surfactant-containing products, such as heavy duty liquid laundry detergents. Many \u201cStandard\u201d matrix systems available effectively become \u201cEquilibrium\u201d systems when formulated into aqueous-based products. One may select an \u201cEquilibrium\u201d system or a Reservoir system, which has acceptable in-product diffusion stability and available triggers for release (e.g., friction). \u201cEquilibrium\u201d systems are those in which the perfume and polymer may be added separately to the product, and the equilibrium interaction between perfume and polymer leads to a benefit at one or more consumer touch points (versus a free perfume control that has no polymer-assisted delivery technology). The polymer may also be pre-loaded with perfume; however, part or all of the perfume may diffuse during in-product storage reaching an equilibrium that includes having desired perfume raw materials (PRMs) associated with the polymer. The polymer then carries the perfume to the surface, and release is typically via perfume diffusion. The use of such equilibrium system polymers has the potential to decrease the neat product odor intensity of the neat product (usually more so in the case of pre-loaded standard system). Deposition of such polymers may serve to \u201cflatten\u201d the release profile and provide increased longevity. As indicated above, such longevity would be achieved by suppressing the initial intensity and may enable the formulator to use more high impact or low odor detection threshold (ODT) or low Kovats Index (KI) PRMs to achieve FMOT benefits without initial intensity that is too strong or distorted. It is important that perfume release occurs within the time frame of the application to impact the desired consumer touch point or touch points. Suitable micro-particles and micro-latexes as well as methods of making same may be found in USPA 2005/0003980 A1. Matrix systems also include hot melt adhesives and perfume plastics. In addition, hydrophobically modified polysaccharides may be formulated into the perfumed product to increase perfume deposition and/or modify perfume release. All such matrix systems, including for example polysaccharides and nanolatexes may be combined with other PDTs, including other PAD systems such as PAD reservoir systems in the form of a perfume microcapsule (PMC). Polymer Assisted Delivery (PAD) matrix systems may include those described in the following references: US Patent Application 2004/0110648 A1 and U.S. Pat. No. 6,531,444. - Silicones are also examples of polymers that may be used as PDT, and can provide perfume benefits in a manner similar to the polymer-assisted delivery \u201cmatrix system\u201d. Such a PDT is referred to as silicone-assisted delivery (SAD). One may pre-load silicones with perfume, or use them as an equilibrium system as described for PAD. Suitable silicones as well as making same may be found in USPA 20050143282A1. Functionalized silicones may also be used as described in USPA 2006/003913 A1. Examples of silicones include polydimethylsiloxane and polyalkyldimethylsiloxanes. Other examples include those with amine functionality, which may be used to provide benefits associated with amine-assisted delivery (AAD) and/or polymer-assisted delivery (PAD) and/or amine-reaction products (ARP). Other such examples may be found in USPA 2005/0003980 A1. - b.) Reservoir Systems: Reservoir systems are also known as a core-shell type technology, or one in which the fragrance is surrounded by a perfume release controlling membrane, which may serve as a protective shell. The material inside the microcapsule is referred to as the core, internal phase, or fill, whereas the wall is sometimes called a shell, coating, or membrane. Microparticles or pressure sensitive capsules or microcapsules are examples of this technology. Microcapsules of the current invention are formed by a variety of procedures that include, but are not limited to, coating, extrusion, spray-drying, interfacial, in-situ and matrix polymerization. The possible shell materials vary widely in their stability toward water. Among the most stable are polyoxymethyleneurea (PMU)-based materials, which may hold certain PRMs for even long periods of time in aqueous solution (or product). Such systems include but are not limited to urea-formaldehyde and/or melamine-formaldehyde. Gelatin-based microcapsules may be prepared so that they dissolve quickly or slowly in water, depending for example on the degree of cross-linking. Many other capsule wall materials are available and vary in the degree of perfume diffusion stability observed. Without wishing to be bound by theory, the rate of release of perfume from a capsule, for example, once deposited on a surface is typically in reverse order of in-product perfume diffusion stability. As such, urea-formaldehyde and melamine-formaldehyde microcapsules for example, typically require a release mechanism other than, or in addition to, diffusion for release, such as mechanical force (e.g., friction, pressure, shear stress) that serves to break the capsule and increase the rate of perfume (fragrance) release. Other triggers include melting, dissolution, hydrolysis or other chemical reaction, electromagnetic radiation, and the like. Suitable capsule wall materials include, in addition to aminoplasts, polyvinyl alcohol, polyvinyl pyrrolidone, polyethylene glycol, polysaccharides and modified polysaccharides, gel forming proteins, modified celluloses such as carboxymethylcelluloses and hydroxyethylcelluloses, polyacrylates, polyureas, polyurethanes and mixtures thereof. The capsules may be further coated with an additional coating that can improve the deposition and/or retention of the capsule on the desired surface. Suitable coating materials include a cationic polymer selected from the group consisting of selected from the group consisting of polysaccharides, cationically modified starch, cationically modified guar, polysiloxanes, poly diallyl dimethyl ammonium halides, copolymers of poly diallyl dimethyl ammonium chloride and vinyl pyrrolidone, acrylamides, imidazoles, imidazolinium halides, imidazolium halides, poly vinyl amine, copolymers of poly vinyl amine and N-vinyl formamide to the surface of the capsule to form a cationically coated polymer encapsulated material. Typical capsules have a diameter of 1 micron to 500 microns. The use of pre-loaded microcapsules requires the proper ratio of in-product stability and in-use and/or on-surface (on-situs) release, as well as proper selection of PRMs. Microcapsules that are based on urea-formaldehyde and/or melamine-formaldehyde are relatively stable, especially in near neutral aqueous-based solutions. These materials may require a friction trigger which may not be applicable to all product applications. Other microcapsule materials (e.g., gelatin) may be unstable in aqueous-based products and may even provide reduced benefit (versus free perfume control) when in-product aged."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": null, "compound_ref_verbatim": null, "confidence": 0.45, "construct": {"method_text_verbatim": "This technology refers to perfume technologies that result from the reaction of perfume materials with other substrates or chemicals to form materials that have a covalent bond between one or more PRMs and one or more carriers. The PRM is converted into a new material called a pro-PRM (i.e., pro-perfume), which then may release the original PRM upon exposure to a trigger such as water or light. Pro-perfumes may provide enhanced perfume delivery properties such as increased perfume deposition, longevity, stability, retention, and the like. Pro-perfumes include those that are monomeric (non-polymeric) or polymeric, and may be pre-formed or may be formed in-situ under equilibrium conditions, such as those that may be present during in-product storage or on the wet or dry situs. Nonlimiting examples of pro-perfumes include Michael adducts (e.g., beta-amino ketones), aromatic or non-aromatic imines (Schiffs Bases), oxazolidines, beta-keto esters, and orthoesters. Another aspect includes com", "panel_size": null, "property_name": "longevity", "scale": "numeric_unknown", "substrate": null, "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "2006/0020459", "patent_id": "US20140170194A1", "provenance": {"citation": "US20140170194A1", "retrieval_source": "Firecrawl scrape of Google Patents public page", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20140170194A1/en"}, "pub_date": null, "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description_translated_from:547", "units": "ordinal_ratio", "verbatim_quote": "This technology refers to perfume technologies that result from the reaction of perfume materials with other substrates or chemicals to form materials that have a covalent bond between one or more PRMs and one or more carriers. The PRM is converted into a new material called a pro-PRM (i.e., pro-perfume), which then may release the original PRM upon exposure to a trigger such as water or light. Pro-perfumes may provide enhanced perfume delivery properties such as increased perfume deposition, longevity, stability, retention, and the like. Pro-perfumes include those that are monomeric (non-polymeric) or polymeric, and may be pre-formed or may be formed in-situ under equilibrium conditions, such as those that may be present during in-product storage or on the wet or dry situs. Nonlimiting examples of pro-perfumes include Michael adducts (e.g., beta-amino ketones), aromatic or non-aromatic imines (Schiffs Bases), oxazolidines, beta-keto esters, and orthoesters. Another aspect includes compounds comprising one or more beta-oxy or beta-thio carbonyl moieties capable of releasing a PRM, for example, an alpha, beta-unsaturated ketone, aldehyde or carboxylic ester. The typical trigger for perfume release is exposure to water; although other triggers may include enzymes, heat, light, pH change, autoxidation, a shift of equilibrium, change in concentration or ionic strength and others. For aqueous-based products, light-triggered pro-perfumes are particularly suited. Such photo-pro-perfumes (PPPs) include but are not limited to those that release coumarin derivatives and perfumes and/or pro-perfumes upon being triggered. The released pro-perfume may release one or more PRMs by means of any of the above mentioned triggers. In one aspect, the photo-pro-perfume releases a nitrogen-based pro-perfume when exposed to a light and/or moisture trigger. In another aspect, the nitrogen-based pro-perfume, released from the photo-pro-perfume, releases one or more PRMs selected, for example, from aldehydes, ketones (including enones) and alcohols. In still another aspect, the PPP releases a dihydroxy coumarin derivative. The light-triggered pro-perfume may also be an ester that releases a coumarin derivative and a perfume alcohol. In one aspect the pro-perfume is a dimethoxybenzoin derivative as described in USPA 2006/0020459 A1. In another aspect the pro-perfume is a 3\u2032,5\u2032-dimethoxybenzoin (DMB) derivative that releases an alcohol upon exposure to electromagnetic radiation. In yet another aspect, the pro-perfume releases one or more low ODT PRMs, including tertiary alcohols such as linalool, tetrahydrolinalool, or dihydromyrcenol. Suitable pro-perfumes and methods of making same can be found in U.S. Pat. No. 7,018,978 B2."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": null, "compound_ref_verbatim": "Example 9", "confidence": 0.9, "construct": {"method_text_verbatim": "Example 8Synthesis of 3-\\[(4R)-4-isopropylcyclohexen-1-yl)propanal (Ia)- \\[0281\\]\\ \\ \\ \\ \\ \\ - \\[0282\\]\\ \\ A mixture of 24 g of (4R)-2-(1-butoxyethoxy)-4-isopropyl-1-methylene cyclohexane (77%, 72 mmol, 1.00 equiv., formula (IIa) as defined above) and 2.5 g hexanoic acid (21 mmol, 0.30 equiv.) in 25 g Malotherm S is heated at 200\u00b0 C. for 2 hours. During this, the low-boiling products are distilled off. Then the reaction mixture is cooled at room temperature and distilled over soda. 14.7 g of 3-\\[(4R)-4-isopropylcyclohexen-1-yl\\]-propanal (formula (Ia) as defined above) is isolated at a purity of 52% and with 96.6% ee. This corresponds to a yield of 58% of theory. Some of the product is purified on a column (cyclohexane: ethyl acetate 100:3, 3.34 g, purity 96.5%).\\ \\ - \\[0283\\]\\ \\ \\[\u03b1\\]D22=+108\u00b0 (c=0.07 in ethanol).\u2014GC with chiral stationary phase (Hydrodex-b-TBADc, 25 m\u00d70.25 mm, 40\u00b0 C.\u22121\u00b0 C./min.\u2212180\u00b0 C.): Rt=79.08 (98.3%), 79.30 (1.7%).\u2014MS: m/z (%)=180 (M+\u2033 10), 162 (7), 147 (7), 136 ", "panel_size": null, "property_name": "odor_intensity", "scale": "percent", "substrate": ["fabric", "hair", "skin"], "time_points": ["2 hours", "1H", "3H", "2H", "250 HR", "1 minute", "2 minutes", "20 minutes", "1 hour", "0 days", "1 day", "2 days", "3 days", "4 days", "7 days", "8 days", "9 days"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "2 hours; 1H; 3H; 1.16-1.28; 2H; 1.42-1.50; 1.66-1.80; 1.94-2.06; 2.49-2.54; 5.39-5.43; 80/85; 82/18; 125/055; 250 HR; 1 minute; 1-2; 20 minutes; 125/030; 100/080; 11/90; 2-5; 125/200; 35-40; 4 to 8; 1 hour; 0 days; 1 day; 2 days; 3 days; 4 days; 7 days; 8 days; 9 days; 4 to 7; 7 to 9; 0.01 to 99.99; 0.0001 to 40; 0.0001 to 5; 1 to 10", "patent_id": "US20130090390A1", "provenance": {"citation": "US20130090390A1", "retrieval_source": "Firecrawl scrape of Google Patents public page", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US20130090390A1/en"}, "pub_date": null, "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description_translated_from:381", "units": "hours", "verbatim_quote": "Example 8Synthesis of 3-\\[(4R)-4-isopropylcyclohexen-1-yl)propanal (Ia)- \\[0281\\]\\ \\ \\ \\ \\ \\ - \\[0282\\]\\ \\ A mixture of 24 g of (4R)-2-(1-butoxyethoxy)-4-isopropyl-1-methylene cyclohexane (77%, 72 mmol, 1.00 equiv., formula (IIa) as defined above) and 2.5 g hexanoic acid (21 mmol, 0.30 equiv.) in 25 g Malotherm S is heated at 200\u00b0 C. for 2 hours. During this, the low-boiling products are distilled off. Then the reaction mixture is cooled at room temperature and distilled over soda. 14.7 g of 3-\\[(4R)-4-isopropylcyclohexen-1-yl\\]-propanal (formula (Ia) as defined above) is isolated at a purity of 52% and with 96.6% ee. This corresponds to a yield of 58% of theory. Some of the product is purified on a column (cyclohexane: ethyl acetate 100:3, 3.34 g, purity 96.5%).\\ \\ - \\[0283\\]\\ \\ \\[\u03b1\\]D22=+108\u00b0 (c=0.07 in ethanol).\u2014GC with chiral stationary phase (Hydrodex-b-TBADc, 25 m\u00d70.25 mm, 40\u00b0 C.\u22121\u00b0 C./min.\u2212180\u00b0 C.): Rt=79.08 (98.3%), 79.30 (1.7%).\u2014MS: m/z (%)=180 (M+\u2033 10), 162 (7), 147 (7), 136 (34), 119 (24), 109 (18), 93 (100), 79 (41), 67 (56), 55 (34), 41 (69), 27 (33).\u20141H NMR (400 MHz, CDCl3): \u03b4 (ppm)=0.87 (d, J=6.8 Hz, 3H), 0.88 (d, J=0.88 Hz, 3H), 1.16-1.28 (m, 2H), 1.42-1.50 (m, 1H), 1.66-1.80 (m, 2H), 1.94-2.06 (m, 3H), 2.28 (t, J=7.5 Hz, 2H), 2.49-2.54 (m, 2H), 5.39-5.43 (m, 1H), 9.75 (t, J=1.9 Hz, 1H).\u201413C NMR (100 MHz, CDCl3): \u03b4 (ppm)=19.6 (CH3), 19.9 (CH3), 26.3 (CH2), 28.8 (CH2), 29.2 (CH2), 29.7 (CH2), 32.2 (CH), 40.0 (CH), 41.9 (CH2), 121.8 (CH), 135.5 (cquart), 202.8 (CHO).\\ \\ Example 9 Fine Fragrance (Perfume Oil)- \\[0284\\]\\ \\ - | | |\\ | --- | --- |\\ | | |\\ | | Parts by weight |\\ \\ \\ \\ | | | |\\ | --- | --- | --- |\\ | | | Perfume |\\ | | | oil A2 |\\ | | | (according |\\ | | Perfume oil A1 | to the |\\ | Fragrances | (comparison) | invention) |\\ | |\\ \\ \\ \\ | | | |\\ | --- | --- | --- |\\ | ETHYL ACETOACETATE | 4.0 | 4.0 |\\ | HEXENOL CIS-3 10% DPG | 3.0 | 3.0 |\\ | HEXENYL ACETATE CIS-3 10% DPG | 3.0 | 3.0 |\\ | HEXENYL BENZOATE CIS-3 10% DPG | 3.0 | 3.0 |\\ | VERTOCITRAL 10% DPG | 5.0 | 5.0 |\\ | CYCLOGALBANAT \u00ae 10% DPG | 3.0 | 3.0 |\\ | STYRALYL ACETATE 10% DPG | 6.0 | 6.0 |\\ | BERGAMOT OIL BERGAPTEN FREE FF | 6.0 | 6.0 |\\ | MANDARY OIL DIST. DECOL. | 15.0 | 15.0 |\\ | METHYL ANTHRANILATE 10% DPG | 5.0 | 5.0 |\\ | RED BERRY EXTR. | 2.0 | 2.0 |\\ | DECALACTONE GAMMA | 2.0 | 2.0 |\\ | ALLYL CAPROATE 10% DPG | 5.0 | 5.0 |\\ | PRUNELLA TYPE BASE | 6.0 | 6.0 |\\ | HELIONAL | 20.0 | 20.0 |\\ | MUGETANOL | 10.0 | 10.0 |\\ | ETHYL LINALOOL | 35.0 | 35.0 |\\ | CITRONELLOL 950 | 10.0 | 10.0 |\\ | GERANIOL SUPER | 3.0 | 3.0 |\\ | ROSAPHEN \u00ae | 8.0 | 8.0 |\\ | CITRONELLYL ACETATE EXTRA | 2.0 | 2.0 |\\ | DAMASCONE BETA 10% DPG | 6.0 | 6.0 |\\ | BENZYL ACETATE | 10.0 | 10.0 |\\ | HEDION HC/30 | 30.0 | 30.0 |\\ | HEDIONE | 140.0 | 140.0 |\\ | HEXYL CINNAMIC ALDEHYDE ALPHA | 30.0 | 30.0 |\\ | LACTOJASMONE | 3.0 | 3.0 |\\ | BENZYL SALICYLATE | 80.0 | 80.0 |\\ | HEXENYL SALICYLATE CIS-3 | 30.0 | 30.0 |\\ | METHYL IONONE GAMMA COEUR | 3.0 | 3.0 |\\ | CLOVE BUD OIL | 1.0 | 1.0 |\\ | VANILLIN | 1.5 | 1.5 |\\ | COUMARIN | 1.0 | 1.0 |\\ | AMBERWOOD \u00ae F | 5.0 | 5.0 |\\ | CASHMERAN | 8.0 | 8.0 |\\ | CEDRENE | 15.0 | 15.0 |\\ | ISO E SUPER NON DISCOLORING | 50.0 | 50.0 |\\ | BRAHMANOL \u00ae | 25.0 | 25.0 |\\ | SANDALORE | 5.0 | 5.0 |\\ | AMBROXIDE | 2.0 | 2.0 |\\ | AMBRETTOLIDE | 5.0 | 5.0 |\\ | AURELIONE \u00ae | 16.0 | 16.0 |\\ | GLOBALIDE \u00ae | 24.0 | 24.0 |\\ | MACROLIDE \u00ae SUPRA | 16.0 | 16.0 |\\ | INDOLE FF 10% DPG | 5.0 | 5.0 |\\ | 3-\\[(4R)-4-Isopropylcyclohexen-1-yl\\]propanal | | 50.0 |\\ | DIPROPYLENE GLYCOL | 332.5 | 282.5 |\\ | | 1000.0 | 1000.0 |\\ | |\\ \\ - \\[0285\\]\\ \\ At a dosage of 6 wt % of perfume oil A1 or A2 in ethanol, the findings are as follows: By adding 3-\\[(4R)-4-isopropylcyclohexen-1-yl\\]propanal in perfume oil A2 the floral note is intensified relative to perfume oil A1 (without 3-\\[(4R)-4-isopropylcyclohexen-1-yl\\]propanal). Furthermore, 3-\\[(4R)-4-isopropylcyclohexen-1-yl\\]propanal endows the composition with perfume oil A2 more power and fullness than the composition with perfume oil A1; on the whole, addition of 3-\\[(4R)-4-isopropylcyclohexen-1-yl\\]propanal results in an odor impression reminiscent of lily of the valley.\\ \\ Example 10Body Lotion- \\[0286\\]\\ \\ - | |\\ | :-: |\\ | Component | wt % | wt % |\\ | --- | --- | --- |\\ | |\\ | :-: |\\ | Paraffin oil | 5.00 | 5.00 |\\ | Isopropyl palmitate | 5.00 | 5.00 |\\ | Cetyl alcohol | 2.00 | 2.00 |\\ | Beeswax | 2.00 | 2.00 |\\ | Ceteareth-20 | 2.00 | 2.00 |\\ | PEG-20-glyceryl stearate | 1.50 | 1.50 |\\ | Glycerol | 3.00 | 3.00 |\\ | Phenoxyethanol | 0.50 | \u2014 |\\ | Parabens (mixture of methyl, ethyl, propyl, butyl, | \u2014 | 0.50 |\\ | isobutyl paraben) |\\ | Perfume oil B1 or B2 | 0.50 | 0.50 |\\ | Water | to 100 | to 100 |\\ | |\\ \\ - \\[0287\\]\\ \\ Composition of the perfume oil B1 or B2:\\ \\ - | | |\\ | --- | --- |\\ | | |\\ | | Parts by weight |\\ \\ \\ \\ | | | |\\ | --- | --- | --- |\\ | | | Perfume oil |\\ | | | B2 |\\ | | Perfume oil | (according |\\ | | B1 | to the |\\ | Fragrances | (comparison) | invention) |\\ | |\\ \\ \\ \\ | | | |\\ | --- | --- | --- |\\ | NONADIENAL TRANS, CIS-2.6 5% TEC | 2.0 | 2.0 |\\ | 20% DPG |\\ | ETHYL ACETOACETATE | 3.0 | 3.0 |\\ | FARENAL \u00ae 10% DPG | 5.0 | 5.0 |\\ | VERTOCITRAL | 3.0 | 3.0 |\\ | CYCLOGALBANAT \u00ae 10% DPG | 2.0 | 2.0 |\\ | STYRALYL ACETATE | 3.0 | 3.0 |\\ | MELONAL \u00ae | 0.5 | 0.5 |\\ | DIHYDROMYRCENOL | 15.0 | 15.0 |\\ | LINALYL ACETATE | 20.0 | 20.0 |\\ | LEMON OIL TERPENE FLAVOR WONF | 8.0 | 8.0 |\\ | EUCALYPTOL NATURAL. 10% DPG | 0.5 | 0.5 |\\ | HEXYL ACETATE | 1.5 | 1.5 |\\ | ISOAMYL ACETATE 10% DPG | 4.0 | 4.0 |\\ | PRENYL ACETATE 10% DPG | 4.0 | 4.0 |\\ | ALDEHYDE C14 SO-CALLED | 2.0 | 2.0 |\\ | ETHYL METHYL BUTYRATE-2 | 1.0 | 1.0 |\\ | ALLYL CYCLOHEXYL PROPIONATE | 2.0 | 2.0 |\\ | ALDEHYDE C16 SO-CALLED | 1.0 | 1.0 |\\ | FRAGOLANE \u00ae | 0.5 | 0.5 |\\ | MAJANTOL \u00ae | 25.0 | 25.0 |\\ | LINALOOL | 40.0 | 40.0 |\\ | DIMETHYL BENZYL CARBINOL | 10.0 | 10.0 |\\ | TERPINEOL PURE | 10.0 | 10.0 |\\ | PHENIRAT \u00ae | 30.0 | 30.0 |\\ | CITRONELLOL 950 | 15.0 | 15.0 |\\ | GERANIOL 60 | 10.0 | 10.0 |\\ | CITRONELLYL ACETATE EXTRA | 2.0 | 2.0 |\\ | HEDIONE | 90.0 | 90.0 |\\ | HEXYL CINNAMIC ALDEHYDE ALPHA | 35.0 | 35.0 |\\ | HEXYL SALICYLATE | 160.0 | 160.0 |\\ | METHYL OCTIN CARBONATE 10% DPG | 2.0 | 2.0 |\\ | CALONE 1951 10% DPG | 1.0 | 1.0 |\\ | GALAXOLIDE 50% IN IPM | 20.0 | 20.0 |\\ | ANETHOLE SUPRA 21.5 CELSIUS | 2.0 | 2.0 |\\ | AGRUMEX HC | 15.0 | 15.0 |\\ | ORYCLON SPECIAL | 40.0 | 40.0 |\\ | 3-\\[(4R)-4-Isopropylcyclohexen-1-yl\\]propanal | | 15.0 |\\ | DIPROPYLENE GLYCOL | 415.0 | 400.0 |\\ | | 1000.0 | 1000.0 |\\ | |\\ \\ - \\[0288\\]\\ \\ At a dosage of 0.5 wt % of perfume oil B1 or B2 in the body lotion, the findings are as follows: due to the proportion of 3-\\[(4R)-4-isopropylcyclohexen-1-yl\\]propanal, the body lotion containing perfume oil B2 has a stronger and more natural floral note than the body lotion that contains perfume oil B1 (without 3-\\[(4R)-4-isopropylcyclohexen-1-yl\\] propanal). Furthermore, the body lotion with perfume oil B2 displays a more cosmetic top note and a creamier bottom note than the body lotion with perfume oil B1; on the whole, addition of 3-\\[(4R)-4-isopropylcyclohexen-1-yl\\]propanal results in an odor impression reminiscent of lily of the valley.\\ \\ Example 11 Fabric Softener- \\[0289\\]\\ \\ - | |\\ | :-: |\\ | Material | Manufacturer | Chemical name | Function | wt % |\\ | --- | --- | --- | --- | --- |\\ | |\\ | :-: |\\ | |\\ \\ \\ \\ | | | | | |\\ | --- | --- | --- | --- | --- |\\ | Deionized water | | Water | Solvent | 72.4 |\\ | Rewoquat WE 18 | Evonik | Dialkylesterammonium | Cationic | 16.6 |\\ | | Goldschmidt | ethosulfate | surfactant |\\ | | GmbH |\\ | Mergal K9N | Honeywell | 5-Chloro-2-methyl-3- | Preservative | 0.10 |\\ | | Austria GmbH | (2H)-isothiazolone and |\\ | | | 2-methyl-3-(2H)- |\\ | | | isothiazolone |\\ | Dow Corning 1520 | Dow Corning | Polydimethylsiloxane | Antifoaming | 0.30 |\\ | Antifoam | GmbH, | | agent |\\ | Magnesium chloride | | Magnesium chloride | Consistency | 10.00 |\\ | 1% solution | | solution | agent |\\ | Perfume Oil C1 or C2 | Symrise | | Perfume | 0.60 |\\ | | | | (fragrance) |\\ | |\\ \\ - \\[0290\\]\\ \\ Composition of perfume oil C1 or C2:\\ \\ - | | |\\ | --- | --- |\\ | | |\\ | | Parts by weight |\\ \\ \\ \\ | | | |\\ | --- | --- | --- |\\ | | | Perfume oil |\\ | | | C2 |\\ | | Perfume oil | (according |\\ | | C1 | to the |\\ | Fragrances | (comparison) | invention) |\\ | |\\ \\ \\ \\ | | | |\\ | --- | --- | --- |\\ | ALDEHYDE C10 | 0.5 | 0.5 |\\ | ALDEHYDE C11 ISO | 2.0 | 2.0 |\\ | ALDEHYDE C11 UNDECYLENIC | 12.0 | 12.0 |\\ | ALDEHYDE C12 MNA | 6.0 | 6.0 |\\ | FARENAL \u00ae | 1.0 | 1.0 |\\ | VERTOCITRAL | 8.0 | 8.0 |\\ | ALLYL AMYL GLYCOLATE | 1.0 | 1.0 |\\ | STYRALYL ACETATE | 1.5 | 1.5 |\\ | DIHYDROMYRCENOL | 65.0 | 65.0 |\\ | AGRUNITRIL | 1.0 | 1.0 |\\ | PEONILE | 15.0 | 15.0 |\\ | METHYL ANTHRANILATE | 10.0 | 10.0 |\\ | NEROLIONE 10% DPG | 1.5 | 1.5 |\\ | ROSEMARY OIL BM | 7.0 | 7.0 |\\ | SAGE OFFICINALE OIL DALM. | 3.0 | 3.0 |\\ | ISOBORNYL ACETATE | 40.0 | 40.0 |\\ | PRENYL ACETATE | 0.5 | 0.5 |\\ | ISOAMYL BUTYRATE E | 0.5 | 0.5 |\\ | ALDEHYDE C14 SO-CALLED | 5.0 | 5.0 |\\ | MANZANATE | 0.5 | 0.5 |\\ | MUGETANOL | 5.0 | 5.0 |\\ | DIMETHYL BENZYL CARBINYL | 2.5 | 2.5 |\\ | ACETATE |\\ | ROSE OXIDE D | 3.0 | 3.0 |\\ | ANTHER | 0.5 | 0.5 |\\ | PHENYLETHYL ALCOHOL | 35.0 | 35.0 |\\ | CITRONELLOL 950 | 15.0 | 15.0 |\\ | GERANIOL 60 | 10.0 | 10.0 |\\ | ISODAMASCON \u00ae | 2.0 | 2.0 |\\ | ROSACETATE | 35.0 | 35.0 |\\ | CRESYL METHYL ETHER PARA | 0.5 | 0.5 |\\ | BENZYL ACETATE | 20.0 | 20.0 |\\ | HEXYL CINNAMIC ALDEHYDE ALPHA | 40.0 | 40.0 |\\ | METHYL BENZOATE | 1.0 | 1.0 |\\ | AMYL SALICYLATE N/ISO | 10.0 | 10.0 |\\ | BENZYL SALICYLATE | 70.0 | 70.0 |\\ | MYSORE ACETATE | 15.0 | 15.0 |\\ | PARMANYL \u00ae | 0.5 | 0.5 |\\ | EUGENOL | 10.0 | 10.0 |\\ | ETHYL VANILLIN | 0.5 | 0.5 |\\ | COUMARIN | 3.0 | 3.0 |\\ | AGRUMEX HC | 45.0 | 45.0 |\\ | HERBAFLORAT | 25.0 | 25.0 |\\ | AMBERWOOD \u00ae F | 5.0 | 5.0 |\\ | ISO E SUPER | 170.0 | 170.0 |\\ | PATCHOULI OIL DECOL. | 2.5 | 2.5 |\\ | SANDRANOL \u00ae | 10.0 | 10.0 |\\ | ISOBUTYL QUINOLINE | 1.0 | 1.0 |\\ | EVERNYL | 0.5 | 0.5 |\\ | AMBROXIDE | 1.0 | 1.0 |\\ | GALAXOLIDE 50% IN IPM | 120.0 | 120.0 |\\ | INDOFLOR \u00ae CRYST. | 0.5 | 0.5 |\\ | 3-\\[(4R)-4-Isopropylcyclohexen-1-yl\\]propanal | | 60.0 |\\ | DIPROPYLENE GLYCOL | 220.0 | 160.0 |\\ | | 1000.0 | 1000.0 |\\ | |\\ \\ - \\[0291\\]\\ \\ At a dosage of 0.6 wt % of perfume oil C1 or C2 in the fabric softener, the findings are as follows: due to the proportion of 3-\\[(4R)-4-isopropylcyclohexen-1-yl\\]propanal, the fabric softener containing perfume oil C2 has a more natural, fresher floral note than the fabric softener that contains perfume oil C1 (without 3-\\[(4R)-4-isopropylcyclohexen-1-yl\\] propanal); on the whole, addition of 3-\\[(4R)-4-isopropylcyclohexen-1-yl\\]propanal results in an odor impression reminiscent of lily of the valley.\\ \\ Example 12 Soap- \\[0292\\]\\ \\ - | |\\ | :-: |\\ | Material | Manufacturer | Chemical name | Function | wt % |\\ | --- | --- | --- | --- | --- |\\ | |\\ | :-: |\\ | |\\ \\ \\ \\ | | | | | |\\ | --- | --- | --- | --- | --- |\\ | Deionized water | | Water | Solvent | 2.0 |\\ | Soap Base Mix | Various | Sodium | Surfactants | 95.8 |\\ | | | tallowates/ |\\ | | | palmitates |\\ | Titanium dioxide | Kronos Titan | Titanium | Pigment/ | 1.0 |\\ | | GmbH, | dioxide | Lightening |\\ | | Germany | | agent |\\ | Perfume oil D1 | Symrise | | Perfume | 1.2 |\\ | or D2 | | | (fragrance) |\\ | |\\ \\ - \\[0293\\]\\ \\ Composition of perfume oil D1 or D2:\\ \\ - | | |\\ | --- | --- |\\ | | |\\ | | Parts by weight |\\ \\ \\ \\ | | | |\\ | --- | --- | --- |\\ | | | Perfume oil |\\ | | | D2 |\\ | | Perfume oil | (according |\\ | | D1 | to the |\\ | Fragrances | (comparison) | invention) |\\ | |\\ \\ \\ \\ | | | |\\ | --- | --- | --- |\\ | ALDEHYDE C 8 | 10.0 | 10.0 |\\ | ALDEHYDE C10 | 14.0 | 14.0 |\\ | ALDEHYDE C11 UNDECYLIC | 5.0 | 5.0 |\\ | ALDEHYDE C12 MNA | 4.0 | 4.0 |\\ | ISOAMYL ALCOHOL | 6.0 | 6.0 |\\ | VERTOCITRAL | 4.0 | 4.0 |\\ | ALLYL AMYL GLYCOLATE | 4.0 | 4.0 |\\ | DIHYDROMYRCENOL | 120.0 | 120.0 |\\ | CITRAL 95 | 30.0 | 30.0 |\\ | AGRUNITRIL | 80.0 | 80.0 |\\ | CITRONITRILE | 40.0 | 40.0 |\\ | CITRYLAL | 4.0 | 4.0 |\\ | ORANGE OIL TERPENES | 250.0 | 250.0 |\\ | METHYL ANTHRANILATE | 1.5 | 1.5 |\\ | TERPINEOL HEAD FRACTION | 10.0 | 10.0 |\\ | EUCALYPTOL NAT. | 10.0 | 10.0 |\\ | THYMOL CRYST | 6.0 | 6.0 |\\ | BORNYL ACETATE L CRYST. | 82.5 | 82.5 |\\ | CAMPHOR DL | 20.0 | 20.0 |\\ | JASMAPRUNAT | 5.0 | 5.0 |\\ | ALDEHYDE C14 SO-CALLED | 2.0 | 2.0 |\\ | MANZANATE | 0.5 | 0.5 |\\ | ALLYL HEPTOATE | 2.5 | 2.5 |\\ | ROSE OXIDE L | 0.5 | 0.5 |\\ | DAMASCONE ALPHA | 0.5 | 0.5 |\\ | HEDIONE | 10.0 | 10.0 |\\ | AMYL SALICYLATE N/ISO | 60.0 | 60.0 |\\ | HEXYL SALICYLATE | 35.0 | 35.0 |\\ | COUMARIN | 2.5 | 2.5 |\\ | AGRUMEX HC | 30.0 | 30.0 |\\ | ORYCLON SPECIAL | 55.0 | 55.0 |\\ | PATCHOULI OIL DECOL. | 2.0 | 2.0 |\\ | SANDRANOL \u00ae | 1.5 | 1.5 |\\ | TONALIDE | 2.0 | 2.0 |\\ | 3-\\[(4R)-4-Isopropylcyclohexen-1-yl\\]propanal | | 40.0 |\\ | DIPROPYLENE GLYCOL | 130.0 | 90.0 |\\ | | 1000.0 | 1000.0 |\\ | |\\ \\ - \\[0294\\]\\ \\ At a dosage of 1.2 wt % of perfume oil D1 or D2 in the soap, the findings are as follows: due to the proportion of 3-\\[(4R)-4-isopropylcyclohexen-1-yl\\]propanal, the soap containing perfume oil D2 has a round, aldehyde note, in contrast to the soap that contains perfume oil D1 (without 3-\\[(4R)-4-isopropylcyclohexen-1-yl\\] propanal). Furthermore, the soap with perfume oil D2 radiates more naturalness and fullness than the soap with perfume oil D1; on the whole, addition of 3-\\[(4R)-4-isopropylcyclohexen-1-yl\\]propanal results in an odor impression reminiscent of lily of the valley.\\ \\ Example 13 Washing Powder- \\[0295\\]\\ \\ - | |\\ | :-: |\\ | Material | Manufacturer | Chemical name | Function | wt % |\\ | --- | --- | --- | --- | --- |\\ | |\\ | :-: |\\ | |\\ \\ \\ \\ | | | | | |\\ | --- | --- | --- | --- | --- |\\ | Sodium metasilicate | Akzo Nobel | Sodium metasilicate | | 48.0 |\\ | pentahydrate | Chemicals, | pentahydrate |\\ | | Germany |\\ | Sodium hydrogen | Various | Sodium hydrogen | Alkali | 15.0 |\\ | carbonate | | carbonate |\\ | Sodium percarbonate | Various | Sodium carbonate | Bleach | 15.0 |\\ | | | peroxyhydrate |\\ | Peractive AC blue | Clariant | TAED/Na-carboxy- | Activator | 5.00 |\\ | | GmbH, | methylcellulose |\\ | | Germany |\\ | Genapol OA-080 | Clariant | Oxoalcohol C14-15, | Non-ionic | 3.00 |\\ | | GmbH, | 8EO | surfactant |\\ | | Germany |\\ | Texapon K12 powder | Cognis | Sodium lauryl sulfate | Anionic | 7.00 |\\ | | Germany | C12 | surfactant |\\ | | GmbH |\\ | Tinopal CBS-X | Ciba, | | Brightener | 0.50 |\\ | | Germany |\\ | Savinase 6.0 T, Type W | Novozymes | Protease | Enzyme | 0.40 |\\ | Termamyl 120 T | Novozymes | Alpha-amylase | Enzyme | 0.30 |\\ | Sodium sulfate | Various | Sodium sulfate | Filler | 5.50 |\\ | Perfume oil E1 or E2 | Symrise | | Perfume | 0.30 |\\ | | | | (fragrance) |\\ | |\\ \\ - \\[0296\\]\\ \\ Composition of perfume oil E1 or E2:\\ \\ - | | |\\ | --- | --- |\\ | | |\\ | | Parts by weight |\\ \\ \\ \\ | | | |\\ | --- | --- | --- |\\ | | | Perfume oil |\\ | | | E2 |\\ | | Perfume oil | (according |\\ | | E1 | to the |\\ | Fragrances | (comparison) | invention) |\\ | |\\ \\ \\ \\ | | | |\\ | --- | --- | --- |\\ | ALDEHYDE C 8 | 0.5 | 0.5 |\\ | HEXENOL CIS-3 | 3.5 | 3.5 |\\ | VERTOCITRAL | 15.0 | 15.0 |\\ | STYRALYL ACETATE | 3.0 | 3.0 |\\ | MELONAL \u00ae | 2.0 | 2.0 |\\ | DIHYDROMYRCENOL | 60.0 | 60.0 |\\ | CITRAL 95 | 6.0 | 6.0 |\\ | ORANGE OIL TERPENES | 20.0 | 20.0 |\\ | EUCALYPTUS OIL GLOBULUS 80/85% | 10.0 | 10.0 |\\ | MENTHONE L/ISOMENTHONE D 82/18 | 1.5 | 1.5 |\\ | HEXYL ACETATE 10% DPG | 5.0 | 5.0 |\\ | ISOPENTYRATE | 4.0 | 4.0 |\\ | ETHYL CAPROATE | 1.0 | 1.0 |\\ | ETHYL METHYL BUTYRATE-2 | 6.0 | 6.0 |\\ | LINALOOL | 10.0 | 10.0 |\\ | DIMETHYL BENZYL CARBINYL | 15.0 | 15.0 |\\ | BUTYRATE |\\ | PHENYLETHYL ALCOHOL | 15.0 | 15.0 |\\ | CITRONELLOL 950 | 20.0 | 20.0 |\\ | GERANIOL 60 | 20.0 | 20.0 |\\ | ISODAMASCON \u00ae | 10.0 | 10.0 |\\ | CRESYL METHYL ETHER PARA | 1.0 | 1.0 |\\ | BENZYL ACETONE | 50.0 | 50.0 |\\ | HEXYL CINNAMIC ALDEHYDE ALPHA | 60.0 | 60.0 |\\ | DIHYDROJASMONE | 1.0 | 1.0 |\\ | METHYL BENZOATE | 0.5 | 0.5 |\\ | HEXYL SALICYLATE | 10.0 | 10.0 |\\ | LEGUMINAL | 6.0 | 6.0 |\\ | IONONE BETA | 20.0 | 20.0 |\\ | ISORALDEINE 70 | 45.0 | 45.0 |\\ | EUGENOL | 2.0 | 2.0 |\\ | ACETOPHENONE 1% DPG | 5.0 | 5.0 |\\ | AGRUMEX HC | 60.0 | 60.0 |\\ | ORYCLON SPECIAL | 40.0 | 40.0 |\\ | HERBAFLORAT | 10.0 | 10.0 |\\ | HERBYL PROPIONATE | 20.0 | 20.0 |\\ | KOAVONE | 20.0 | 20.0 |\\ | VERTOFIX | 40.0 | 40.0 |\\ | ISO E SUPER | 150.0 | 150.0 |\\ | SANDRANOL \u00ae | 20.0 | 20.0 |\\ | AMBROXIDE | 2.0 | 2.0 |\\ | 3-\\[(4R)-4-Isopropylcyclohexen-1-yl\\]propanal | | 60.0 |\\ | DIPROPYLENE GLYCOL | 270.0 | 210.0 |\\ | | 1000.0 | 1000.0 |\\ | |\\ \\ - \\[0297\\]\\ \\ At a dosage of 0.3 wt % of perfume oil E1 or E2 in the washing powder (powder detergent), the findings are as follows: the proportion of 3-\\[(4R)-4-isopropylcyclohexen-1-yl\\]propanal produces, in the washing powder containing perfume oil E2, an intensification of the green notes relative to the washing powder that contains perfume oil E1 (without 3-\\[(4R)-4-isopropylcyclohexen-1-yl\\]propanal). Furthermore, the composition of the washing powder with perfume oil E2 radiates altogether more freshness than the washing powder with perfume oil E1; on the whole, addition of 3-\\[(4R)-4-isopropylcyclohexen-1-yl\\]propanal results in an odor impression reminiscent of lily of the valley.\\ \\ Example 14 General-Purpose Cleaner- \\[0298\\]\\ \\ - | |\\ | :-: |\\ | Material | Manufacturer | Chemical name | Function | wt % |\\ | --- | --- | --- | --- | --- |\\ | |\\ | :-: |\\ | |\\ \\ \\ \\ | | | | | |\\ | --- | --- | --- | --- | --- |\\ | Deionized water | | Water | Solvent | 59.6 |\\ | Mergal K9N | Troy Chemie, | 5-Chloro-2-methyl-3-(2H)- | Preservative | 0.1 |\\ | | Seelze | isothiazolone and 2-methyl- |\\ | | | 3-(2H)-isothiazolone |\\ | Trisodium citrate | Various | Trisodium citrate dihydrate | Complexing | 3.0 |\\ | dihydrate | | | agent |\\ | Zetesol NL-2 | Zschimmer & | Fatty alcohol C12-14- | Anionic | 30.0 |\\ | | Schwarz, | sulfate, sodium | surfactant |\\ | | Germany |\\ | Imbentin C/125/055 | Dr. W. Kolb | Fatty alcohol C12-C15, 8EO | Non-ionic | 5.0 |\\ | | AG chem. | | surfactant |\\ | Ethanol 96% | Various | Ethanol | Solvent | 2.0 |\\ | Perfume oil F1 or | Symrise | | Perfume | 0.3 |\\ | F2 | | | (fragrance) |\\ | |\\ \\ - \\[0299\\]\\ \\ Composition of perfume oil F1 or F2:\\ \\ - | | |\\ | --- | --- |\\ | | |\\ | | Parts by weight |\\ \\ \\ \\ | | | |\\ | --- | --- | --- |\\ | | | Perfume oil |\\ | | | F2 |\\ | | Perfume oil | (according |\\ | | F1 | to the |\\ | Fragrances | (comparison) | invention) |\\ | |\\ \\ \\ \\ | | | |\\ | --- | --- | --- |\\ | ALDEHYDE C10 | 0.5 | 0.5 |\\ | ALCOHOL C10 | 6.0 | 6.0 |\\ | HEXENOL CIS-3 | 1.0 | 1.0 |\\ | LIMONENAL | 4.0 | 4.0 |\\ | VERTOCITRAL | 8.0 | 8.0 |\\ | PHENYLACETALDEHYDE 50% DPG | 1.0 | 1.0 |\\ | MINTONAT | 15.5 | 15.5 |\\ | METHYL ANTHRANILATE | 1.0 | 1.0 |\\ | HEXYL ACETATE | 20.0 | 20.0 |\\ | ALLYL HEPTOATE | 1.0 | 1.0 |\\ | LINALOOL | 30.0 | 30.0 |\\ | DIMETHYL BENZYL CARBINYL | 2.0 | 2.0 |\\ | ACETATE |\\ | PHENYLETHYL ALCOHOL | 150.0 | 150.0 |\\ | CITRONELLOL 950 | 130.0 | 130.0 |\\ | GERANIOL SUPER | 35.0 | 35.0 |\\ | GERANYL ACETATE PURE | 10.0 | 10.0 |\\ | BENZYL ACETATE | 55.0 | 55.0 |\\ | HEDIONE | 15.0 | 15.0 |\\ | HEXYL CINNAMIC ALDEHYDE ALPHA | 130.0 | 130.0 |\\ | CINNAMIC ALCOHOL | 6.0 | 6.0 |\\ | ACETOPHENONE 10% DPG | 1.0 | 1.0 |\\ | JACINTHAFLOR \u00ae | 4.0 | 4.0 |\\ | ISO E SUPER | 20.0 | 20.0 |\\ | GALAXOLIDE 50% IN IPM | 35.0 | 35.0 |\\ | INDOFLOR \u00ae CRYST. | 1.0 | 1.0 |\\ | BHT IONOL | 8.0 | 8.0 |\\ | 3-\\[(4R)-4-Isopropylcyclohexen-1-yl\\]propanal | | 60.0 |\\ | DIPROPYLENE GLYCOL | 370.0 | 310.0 |\\ | | 1000.0 | 1000.0 |\\ | |\\ \\ - \\[0300\\]\\ \\ At a dosage of 0.3 wt % of perfume oil F1 or F2 in the general-purpose cleaner, the findings are as follows: the proportion of 3-\\[(4R)-4-isopropylcyclohexen-1-yl\\]propanal produces, in the general-purpose cleaner containing perfume oil F2, an intensification of the floral note relative to the general-purpose cleaner that contains perfume oil F1 (without 3-\\[(4R)-4-isopropylcyclohexen-1-yl\\]propanal). Moreover, the composition of the general-purpose cleaner with perfume oil F2 seems much creamier and fresher than that of the general-purpose cleaner with perfume oil F1; on the whole, addition of 3-\\[(4R)-4-isopropylcyclohexen-1-yl\\]propanal results in an odor impression reminiscent of lily of the valley.\\ \\ Example 15 Shampoo- \\[0301\\]\\ \\ - | |\\ | :-: |\\ | Material | Manufacturer | INCI Name | wt % |\\ | --- | --- | --- | --- |\\ | |\\ | :-: |\\ | |\\ \\ \\ \\ | | | | |\\ | --- | --- | --- | --- |\\ | Deionized water | | Water | 71.5 |\\ | Plantacare PS 10 | Cognis Germany | Sodium Laureth Sulfate, | 20.0 |\\ | | GmbH | Lauryl Glucoside |\\ | Euperlan PK 771 | Cognis Germany | Glycol Distearate, Sodium | 6.0 |\\ | | GmbH | Lauryl Sulfate, Cocamide |\\ | | | MEA, Laureth-10 |\\ | Dragocid Liquid | Symrise | Phenoxyethanol, | 0.5 |\\ | | | Methylparaben, |\\ | | | Ethylparaben, |\\ | | | Butylparaben, |\\ | | | Propylparaben, |\\ | | | Isobutylparaben |\\ | Sodium chloride | | Sodium Chloride | 1.4 |\\ | Citric acid | | Citric Acid | 0.1 |\\ | monohydrate |\\ | crystalline |\\ | Perfume oil G1 | Symrise | Perfume (Fragrance) | 0.5 |\\ | or G2 |\\ | |\\ \\ - \\[0302\\]\\ \\ Composition of perfume oil G1 or G2:\\ \\ - | | |\\ | --- | --- |\\ | | |\\ | | Parts by weight |\\ \\ \\ \\ | | | |\\ | --- | --- | --- |\\ | | | Perfume oil |\\ | | | G2 |\\ | | Perfume oil | (according |\\ | | G1 | to the |\\ | Fragrances | (comparison) | invention) |\\ | |\\ \\ \\ \\ | | | |\\ | --- | --- | --- |\\ | FARENAL \u00ae | 3.0 | 3.0 |\\ | FLORAZON | 0.5 | 0.5 |\\ | HEXENYL ACETATE CIS-3 | 3.0 | 3.0 |\\ | VERTOCITRAL | 1.0 | 1.0 |\\ | DYNASCONE 10% DPG | 2.0 | 2.0 |\\ | CYCLOGALBANAT \u00ae | 2.0 | 2.0 |\\ | STYRALYL ACETATE | 1.5 | 1.5 |\\ | DIHYDROMYRCENOL | 6.0 | 6.0 |\\ | OXANTHIA 50% IN TEC 10% DPG | 10.0 | 10.0 |\\ | LEMON OIL ITAL. | 10.0 | 10.0 |\\ | ORANGE OIL BRASIL | 50.0 | 50.0 |\\ | HEXYL ACETATE | 2.0 | 2.0 |\\ | ISOAMYL ACETATE | 0.5 | 0.5 |\\ | PRENYL ACETATE | 0.5 | 0.5 |\\ | ETHYL BUTYRATE 10% DPG | 2.0 | 2.0 |\\ | ALDEHYDE C14 SO-CALLED | 25.0 | 25.0 |\\ | DECALACTONE GAMMA | 5.0 | 5.0 |\\ | ETHYL METHYL BUTYRATE-2 | 1.0 | 1.0 |\\ | ALLYL CAPROATE | 1.5 | 1.5 |\\ | ALLYL CYCLOHEXYL PROPIONATE | 3.0 | 3.0 |\\ | ALLYL HEPTOATE | 2.5 | 2.5 |\\ | MELOZONE | 2.0 | 2.0 |\\ | CALONE 1951 | 0.5 | 0.5 |\\ | MUGETANOL | 10.0 | 10.0 |\\ | LINALOOL | 25.0 | 25.0 |\\ | DIMETHYL BENZYL CARBINYL | 6.0 | 6.0 |\\ | ACETATE |\\ | DIMETHYL BENZYL CARBINYL | 4.0 | 4.0 |\\ | BUTYRATE |\\ | PHENYLETHYL ACETATE | 1.5 | 1.5 |\\ | PHENYLETHYL ALCOHOL | 15.0 | 15.0 |\\ | CITRONELLOL 950 | 10.0 | 10.0 |\\ | GERANIOL SUPER | 5.0 | 5.0 |\\ | GERANYL ACETATE PURE | 15.0 | 15.0 |\\ | ISODAMASCON \u00ae | 2.0 | 2.0 |\\ | BENZYL ACETATE | 15.0 | 15.0 |\\ | HEDIONE | 90.0 | 90.0 |\\ | HEXYL CINNAMIC ALDEHYDE ALPHA | 35.0 | 35.0 |\\ | JASMONE CIS | 0.5 | 0.5 |\\ | BENZYL SALICYLATE | 80.0 | 80.0 |\\ | HEXENYL SALICYLATE CIS-3 | 30.0 | 30.0 |\\ | ISORALDEINE 70 | 35.0 | 35.0 |\\ | HERBAFLORAT | 15.0 | 15.0 |\\ | ISO E SUPER | 15.0 | 15.0 |\\ | ISOBORNYL CYCLOHEXANOL | 30.0 | 30.0 |\\ | BRAHMANOL \u00ae | 10.0 | 10.0 |\\ | AMBROXIDE | 1.5 | 1.5 |\\ | GLOBALIDE \u00ae | 5.0 | 5.0 |\\ | GALAXOLIDE 50% IN DPG | 120.0 | 120.0 |\\ | 3-\\[(4R)-4-Isopropylcyclohexen-1-yl\\]propanal | | 65.0 |\\ | DIPROPYLENE GLYCOL | 290.0 | 225.0 |\\ | | 1000.0 | 1000.0 |\\ | |\\ \\ - \\[0303\\]\\ \\ At a dosage of 0.5 wt % of perfume oil G1 or G2 in the shampoo, the findings are as follows: addition of 3-\\[(4R)-4-isopropylcyclohexen-1-yl\\]propanal intensifies, in the shampoo containing perfume oil G2, the watery-fruity character relative to the shampoo that contains perfume oil G1 (without 3-\\[(4R)-4-isopropylcyclohexen-1-yl\\]propanal). Moreover, in the shampoo with perfume oil G2, the diffusivity is increased relative to the shampoo with perfume oil G1; on the whole, addition of 3-\\[(4R)-4-isopropylcyclohexen-1-yl\\]propanal results in an odor impression reminiscent of lily of the valley.\\ \\ - \\[0304\\]\\ \\ Example 16\\ \\ Shower Gel- \\[0305\\]\\ \\ - | |\\ | :-: |\\ | Material | Manufacturer | INCI Name | wt % |\\ | --- | --- | --- | --- |\\ | |\\ | :-: |\\ | |\\ \\ \\ \\ | | | | |\\ | --- | --- | --- | --- |\\ | Deionized water | | Water | 76.3 |\\ | Plantacare PS 10 | Cognis | Sodium Laureth Sulfate, | 20.0 |\\ | | Germany | Lauryl Glucoside |\\ | | GmbH |\\ | Dragocid liquid | Symrise | Phenoxyethanol, | 0.5 |\\ | | | Methylparaben, |\\ | | | Ethylparaben, |\\ | | | Butylparaben, |\\ | | | Propylparaben, |\\ | | | Isobutylparaben |\\ | Sodium chloride | | Sodium Chloride | 1.4 |\\ | Citric acid | | Citric Acid | 1.3 |\\ | monohydrate |\\ | crystalline |\\ | Perfume oil G1 or G2 | Symrise | Perfume (Fragrance) | 0.5 |\\ | from example 15 |\\ | |\\ \\ - \\[0306\\]\\ \\ At a dosage of 0.5 wt % of perfume oil G1 or G2 in the shower gel, the findings are as follows: the addition of 3-\\[(4R)-4-isopropylcyclohexen-1-yl\\]propanal endows the shower gel containing perfume oil G2 with a more natural and caring note relative to the shower gel that contains perfume oil G1 (without 3-\\[(4R)-4-isopropylcyclohexen-1-yl\\]propanal); on the whole, addition of 3-\\[(4R)-4-isopropylcyclohexen-1-yl\\]propanal results in an odor impression reminiscent of lily of the valley.\\ \\ Example 17 Transparent Deodorant Sticks (Formulations A and B) or Deodorant Cream Sticks (Formulations C and D)- \\[0307\\]\\ \\ - | |\\ | :-: |\\ | | A | B | C | D |\\ | --- | --- | --- | --- | --- |\\ | Component | wt % | wt % | wt % | wt % |\\ | --- | --- | --- | --- | --- |\\ | |\\ | :-: |\\ | Aluminum zirconium | 25.00 | 20.00 | 25.00 | 20.00 |\\ | tetrachlorohydrate - glycine |\\ | complex |\\ | Dimethicone (10 cst) | \u2014 | \u2014 | 5.00 | 5.00 |\\ | Cyclopentasiloxane | \u2014 | 0.50 | 1.00 | 0.50 |\\ | Petroleum jelly | 5.00 | 4.70 | 5.00 | 5.00 |\\ | Ozokerite | 1.00 | 1.50 | \u2014 | \u2014 |\\ | Stearyl alcohol | 12.00 | 12.00 | \u2014 | \u2014 |\\ | 2-Butyloctanoic acid | 0.50 | \u2014 | 0.50 | \u2014 |\\ | Wax | \u2014 | \u2014 | 1.25 | 1.25 |\\ | PPG-14 butyl ether | 9.00 | 9.00 | \u2014 | \u2014 |\\ | Hardened rapeseed oil | \u2014 | \u2014 | 5.00 | 5.00 |\\ | Silicon dioxide | \u2014 | \u2014 | 1.00 | \u2014 |\\ | Farnesol | 0.25 | \u2014 | 0.25 | \u2014 |\\ | Paraffin oil | 0.50 | 0.50 | \u2014 | \u2014 |\\ | Hydrogenated castor oil (castor | 3.50 | 3.50 | \u2014 | \u2014 |\\ | wax) |\\ | Talc | 4.00 | 4.00 | \u2014 | \u2014 |\\ | Behenyl alcohol | 0.20 | 0.20 | \u2014 | \u2014 |\\ | d-Panthenyltriacetate | 1.00 | 1.00 | \u2014 | \u2014 |\\ | Preservative | q.s. | q.s. | q.s. | q.s. |\\ | Perfume oil H1 or H2 | 1.50 | \u2014 | 1.15 | \u2014 |\\ | Perfume oil G2 from example 15 | | 0.90 | \u2014 | 0.75 |\\ | Water | to 100 | to 100 | to 100 | to 100 |\\ | |\\ \\ - \\[0308\\]\\ \\ Composition of perfume oil H1 or H2\\ \\ - | | |\\ | --- | --- |\\ | | |\\ | | Parts by weight |\\ \\ \\ \\ | | | |\\ | --- | --- | --- |\\ | | | Perfume oil |\\ | | | H2 |\\ | | Perfume oil | (according |\\ | | H1 | to the |\\ | Fragrances | (comparison) | invention) |\\ | |\\ \\ \\ \\ | | | |\\ | --- | --- | --- |\\ | ALDEHYDE C10 | 0.5 | 0.5 |\\ | ALDEHYDE C12 MNA 10% DPG | 2.0 | 2.0 |\\ | MINTONAT | 40.0 | 40.0 |\\ | MELOZONE | 0.5 | 0.5 |\\ | VERTOCITRAL | 6.0 | 6.0 |\\ | DIHYDRO MYRCENOL | 120.0 | 120.0 |\\ | TETRAHYDRO MYRCENOL | 10.0 | 10.0 |\\ | AGRUNITRIL | 1.0 | 1.0 |\\ | ORANGE OIL BRASIL | 10.0 | 10.0 |\\ | TAMARINE TYPE BASE | 10.0 | 10.0 |\\ | HEXYL ACETATE | 6.0 | 6.0 |\\ | ALDEHYDE C14 SO-CALLED | 1.0 | 1.0 |\\ | TETRAHYDRO LINALOOL | 40.0 | 40.0 |\\ | DIMETHYL BENZYL CARBINYL | 5.0 | 5.0 |\\ | BUTYRATE |\\ | ORANGE FLOWER ETHER | 5.0 | 5.0 |\\ | PHENYLETHYL ACETATE | 6.5 | 6.5 |\\ | PHENYLETHYL ALCOHOL | 15.0 | 15.0 |\\ | GERANIOL SUPER | 30.0 | 30.0 |\\ | ROSAPHEN \u00ae | 25.0 | 25.0 |\\ | ISODAMASCON \u00ae | 0.5 | 0.5 |\\ | HEDIONE | 300.0 | 300.0 |\\ | UNDECAVERTOL | 0.5 | 0.5 |\\ | ALLYL IONONE | 2.5 | 2.5 |\\ | IONONE BETA | 10.0 | 10.0 |\\ | EUGENOL | 4.0 | 4.0 |\\ | ISO E SUPER | 30.0 | 30.0 |\\ | BRAHMANOL \u00ae | 2.0 | 2.0 |\\ | AMBROXIDE | 2.0 | 2.0 |\\ | GLOBALIDE \u00ae | 12.0 | 12.0 |\\ | GLOBANONE \u00ae | 8.0 | 8.0 |\\ | MACROLIDE \u00aeSUPRA | 45.0 | 45.0 |\\ | 3-\\[(4R)-4-Isopropylcyclohexen-1-yl\\]propanal | | 50.0 |\\ | DIPROPYLENE GLYCOL | 300.0 | 250.0 |\\ | | 1000.0 | 1000.0 |\\ | |\\ \\ Example 18 Antiperspirant Roll-On- \\[0309\\]\\ \\ - | |\\ | :-: |\\ | Component | wt % | wt % |\\ | --- | --- | --- |\\ | |\\ | :-: |\\ | Caprylyl trimethicone (SilCare TM Silicone 31 M 50) | 0.30 | 0.30 |\\ | Steareth-20 (GENAPOL TM HS 200) | 3.00 | 3.00 |\\ | Steareth-2 (GENAPOL TM HS 020) | 1.50 | 1.50 |\\ | Dicaprylyl ether (Cetiol TM OE) | 2.00 | 2.00 |\\ | Coco caprylate/caprate (Cetiol TM LC) | 2.00 | 2.00 |\\ | Glycerin | 2.00 | 2.00 |\\ | Glyceryl stearate (Cutina TM GMS) | 2.00 | 2.00 |\\ | Octyldodecanol (Eutanol TM G) | 1.00 | 1.00 |\\ | Stearyl alcohol | 2.50 | 2.50 |\\ | Aluminum chlorohydrate according to example 1 | 10.00 | 10.00 |\\ | of EP 1321431 |\\ | Avocado Extract _Persea Gratissima_ | 0.30 | 0.20 |\\ | Perfume oil G2 from example 15 | 0.50 | \u2014 |\\ | Perfume oil H2 from example 17 | \u2014 | 0.60 |\\ | Water | to 100 | to 100 |\\ | |\\ \\ Example 19 Antiperspirant Stick- \\[0310\\]\\ \\ - | |\\ | :-: |\\ | Component | wt % | wt % |\\ | --- | --- | --- |\\ | |\\ | :-: |\\ | |\\ \\ \\ \\ | | | |\\ | --- | --- | --- |\\ | Phenyl trimethicone (SilCare TM Silicone 15 M 50) | 13.50 | 13.50 |\\ | Cetearyl alcohol | to 100 | to 100 |\\ | Cetiol CC (dicaprylyl carbonate) | 13.50 | 13.50 |\\ | Stearic acid | 3.50 | 3.50 |\\ | PEG-40-hydrogenated castor oil (Emulsogen TM HCO | 4.10 | 4.10 |\\ | 040) |\\ | PEG-8 distearate (Cithrol 4 DS) | 4.10 | 4.10 |\\ | Petroleum jelly | 6.90 | 6.90 |\\ | Aluminum chlorohydrate | 13.80 | 13.80 |\\ | Aluminum Zirconium Trichlorohydrex Gly | 19.50 | 20.00 |\\ | Ethylhexylglycerin (octoxyglycerin) | 0.30 | 0.20 |\\ | 4-Methyl-4-phenyl-2-pentanol (Vetikol) | 0.25 | 0.10 |\\ | Perfume oil A2 from example 9 | 1.00 | \u2014 |\\ | Perfume oil G2 from example 15 | \u2014 | 0.80 |\\ | |\\ \\ Example 20 Aerosol Spray- \\[0311\\]\\ \\ - | |\\ | :-: |\\ | Component | wt % | wt % | wt % |\\ | --- | --- | --- | --- |\\ | |\\ | :-: |\\ | Octyldodecanol | 0.50 | \u2014 | 0.50 |\\ | Phenoxyethanol | \u2014 | \u2014 | 0.30 |\\ | 1,2-Pentanediol | 1.00 | 1.00 | 0.50 |\\ | 1,2-Hexanediol | 0.25 | 0.15 | 0.25 |\\ | 1,2-Octanediol | 0.25 | 0.25 | 0.25 |\\ | Farnesol | \u2014 | 0.25 | 0.15 |\\ | Ethylhexylglycerin (octoxyglycerin) | 0.50 | 0.30 | 0.50 |\\ | Perfume oil A2 from example 9 | 0.80 | \u2014 | 0.50 |\\ | Perfume oil H2 from example 17 | \u2014 | 1.15 | 0.50 |\\ | Ethanol | to 100 | to 100 | to 100 |\\ | |\\ \\ - \\[0312\\]\\ \\ The mixture obtained after mixing the components given in each case is filled with a propane-butane mixture (2:7) in the weight ratio 2:3 in an aerosol container.\\ \\ Example 21 Hair Conditioner with UV Protection- \\[0313\\]\\ \\ - | |\\ | :-: |\\ | Component | INCI Name | wt % | wt % |\\ | --- | --- | --- | --- |\\ | |\\ | :-: |\\ | Lanette O | Cetearyl Alcohol | 4.00 | 4.00 |\\ | Dragoxat 89 | Ethylhexyl Isononanoate | 4.00 | 4.00 |\\ | Emulsiphos | Potassium Cetyl Phosphate, | 0.50 | 0.50 |\\ | | Hydrogenated Palm Glycerides |\\ | Natrosol 250 HR | Hydroxyethylcellulose | 0.25 | 0.25 |\\ | Neo Heliopan Hydro | Phenylbenzimidazole Sulfonic Acid | 2.00 | 2.00 |\\ | L-arginine | Arginine | 1.20 | 1.20 |\\ | Benzophenone-4 | Benzophenone-4 | 0.50 | 0.50 |\\ | Neo Heliopan AP | Disodium Phenyl Dibenzimidazole | 0.50 | 1.00 |\\ | | Tetrasulfonate |\\ | Edeta BD | Disodium EDTA | 0.05 | 0.05 |\\ | Dragocide liquid | Phenoxyethanol (=and) Methylparaben | 0.80 | 0.80 |\\ | | (=and) Butylparaben (=and) |\\ | | Ethylparaben (=and) Propylparaben |\\ | Dow Corning 949 cationic | Amodimethicone, Cetrimonium | 2.00 | 2.00 |\\ | emulsion | Chloride, Trideceth-12 |\\ | Dow Corning 5200 | Laurylmethicone Copolyol | 0.50 | 0.50 |\\ | Perfume oil B2 from example | Perfume | 0.95 | \u2014 |\\ | 10 |\\ | Perfume oil H2 from example | Perfume | | 1.25 |\\ | 17 |\\ | Water | Water (Aqua) | to 100 | to 100 |\\ | |\\ \\ Example 22 Sunscreen Spray- \\[0314\\]\\ \\ - | |\\ | :-: |\\ | Part | Raw materials | INCI Designation | wt % |\\ | --- | --- | --- | --- |\\ | |\\ | :-: |\\ | |\\ \\ \\ \\ | | | | |\\ | --- | --- | --- | --- |\\ | A | Water, demineralized | Water (aqua) | 69.50 |\\ | | Glycerol | Glycerol | 4.00 |\\ | | 1,3-Butylene glycol | Butylene Glycol | 5.00 |\\ | | D-panthenol | Panthenol | 0.50 |\\ | | Lara care A-200 | Galactoarabinan | 0.25 |\\ | B | Baysilone oil M 10 | Dimethicone | 1.00 |\\ | | Edeta BD | Disodium EDTA | 0.10 |\\ | | Copherol 1250 | Tocopheryl Acetate | 0.50 |\\ | | Cetiol OE | Dicaprylyl Ether | 3.00 |\\ | | Neo Heliopan \u00ae HMS | Homosalate | 5.00 |\\ | | Neo Heliopan \u00ae AV | Ethylhexyl Methoxycinnamate | 6.00 |\\ | | Neo Heliopan \u00ae 357 | Butyl Methoxydibenzoylmethane | 1.00 |\\ | | Corapan TQ | Diethylhexylnaphthalate | 2.00 |\\ | | Alpha Bisabolol | Bisabolol | 0.10 |\\ | | Pemulen TR-2 | Acrylates/C10-30 Alkyl Acrylate | 0.25 |\\ | | | Crosspolymer |\\ | C | Phenoxyethanol | Phenoxyethanol | 0.70 |\\ | | Solbrol M | Methylparaben | 0.20 |\\ | | Solbrol P | Propylparaben | 0.10 |\\ | D | NAOH, 10% | Sodium Hydroxide | 0.60 |\\ | E | Perfume oil B2 from | Fragrance (Perfume) | 0.20 |\\ | | example 10 |\\ | |\\ \\ - \\[0315\\]\\ \\ Method of production: Dissolve Lara Care A-200 in the other constituents of part A, with stirring. Weigh out all the raw materials of part B (without Pemulen) and dissolve the crystalline substances, with heating. Add and disperse the Pemulen. Add part B to part A and homogenize for 1 minute. Add parts C-E and homogenize for a further 1-2 minutes with the Ultra Turrax.\\ \\ Example 23 Sunscreen Soft Cream (W/O), Sun Protection Factor (SPF) 40- \\[0316\\]\\ \\ - | |\\ | :-: |\\ | Part | Raw materials | INCI designation | wt % |\\ | --- | --- | --- | --- |\\ | |\\ | :-: |\\ | |\\ \\ \\ \\ | | | | |\\ | --- | --- | --- | --- |\\ | A | Dehymuls PGPH | Polyglyceryl-2 Dipolyhydroxy | 5.00 |\\ | | | Stearate E |\\ | | Copherol 1250 | Tocopheryl Acetate E | 0.50 |\\ | | Permulgin 3220 | Ozokerite | 0.50 |\\ | | Zinc stearate | Zinc Stearate E | 0.50 |\\ | | Tegosoft TN | C12-15 Alkyl Benzoate E | 10.00 |\\ | | Neo Heliopan \u00ae | Isoamyl-P-Methoxycinnamate E | 2.00 |\\ | | E1000 |\\ | | Neo Heliopan \u00ae 303 | Octocrylene E | 5.00 |\\ | | Neo Heliopan \u00ae MBC | 4-Methylbenzylidene Camphor | 3.00 |\\ | | Zinc oxide neutral | Zinc Oxide E | 5.00 |\\ | B | Water, distilled | Water (Aqua) | to 100 |\\ | | EDETA BD | Disodium EDTA | 0.10 |\\ | | Glycerin | Glycerin | 4.00 |\\ | | Phenoxyethanol | Phenoxyethanol | 0.70 |\\ | | Solbrol M | Methylparaben | 0.20 |\\ | | Solbrol P | Propylparaben | 0.10 |\\ | | Magnesium sulfate | Magnesium Sulfate | 0.50 |\\ | C | Perfume oil B2 from | Perfume (Fragrance) | 0.30 |\\ | | example 10 |\\ | |\\ \\ - \\[0317\\]\\ \\ Method of production: Heat part A to approx. 85\u00b0 C. Heat part B (without zinc oxide) to approx. 85\u00b0 C.; add zinc oxide and disperse with the Ultra Turrax. Add B to A. Leave to cool, with stirring. Add part C and then homogenize.\\ \\ Example 24 Sunscreen Milk (W/O)- \\[0318\\]\\ \\ - | |\\ | :-: |\\ | Part | Raw materials | INCI Designation | wt % |\\ | --- | --- | --- | --- |\\ | |\\ | :-: |\\ | |\\ \\ \\ \\ | | | | |\\ | --- | --- | --- | --- |\\ | A | Dehymuls PGPH | Polyglyceryl-2 | 3.00 |\\ | | | Dipolyhydroxystearate |\\ | | Beeswax 8100 | Beeswax | 1.00 |\\ | | Monomuls 90-O-18 | Glyceryl Oleate | 1.00 |\\ | | Zinc stearate | Zinc Stearate | 1.00 |\\ | | Cetiol SN | Cetearyl Isononanoate | 5.00 |\\ | | Cetiol OE | Dicaprylyl Ether | 5.00 |\\ | | Tegosoft TN | C12-15 Alkyl Benzoate | 4.00 |\\ | | Vitamin E | Tocopherol | 0.50 |\\ | | Solbrol P | Propylparaben | 0.10 |\\ | | Neo Heliopan \u00ae OS | Ethylhexyl Salicylate | 5.00 |\\ | | Neo Heliopan \u00ae AV | Ethylhexyl Methoxycinnamate | 7.50 |\\ | | Uvinul \u00ae T150 | Ethylhexyl Triazone | 1.50 |\\ | B | Water, distilled | Water (Aqua) | to 100 |\\ | | Trilon BD | Disodium EDTA | 0.10 |\\ | | Glycerin | Glycerin | 5.00 |\\ | | Solbrol M | Methylparaben | 0.20 |\\ | | Phenoxyethanol | Phenoxyethanol | 0.70 |\\ | | Neo Heliopan \u00ae AP | Disodium Phenyl | 15.00 |\\ | | 10% solution, neutralized | Dibenzimidazole |\\ | | with NAOH | Tetrasulfonate |\\ | C | Perfume oil G2 from | Perfume (Fragrance) | 0.25 |\\ | | example 15 |\\ | | Alpha bisabolol | Bisabolol | 0.10 |\\ | |\\ \\ - \\[0319\\]\\ \\ Method of production: Heat part A to approx. 85\u00b0 C. Heat part B to approx. 85\u00b0 C. Add B to A. Leave to cool, with stirring. Add part C and then homogenize.\\ \\ Example 25 Permanent Hair Colorant- \\[0320\\]\\ \\ Part A\u2014Hair coloring base:\\ \\ - | | |\\ | --- | :-: |\\ | | Raw materials | wt % |\\ | --- | --- | --- |\\ | | |\\ | --- | :-: |\\ | |\\ \\ \\ \\ | | | |\\ | --- | --- | --- |\\ | | Sodium myreth sulfate (e.g. texapon K14 S/K, Cognis) | 2.80 |\\ | | Linoleamidopropyl PG-dimonium chloride phosphate | 1.00 |\\ | | (Arlasilk Phospholipid EFA, Uniqema) |\\ | | Caprylyl/capryl glucoside (Plantacare 810 UP, Cognis) | 2.00 |\\ | | Sodium laureth-6 carboxylate (Akypo Soft 45 NV, Kao) | 10.00 |\\ | | Cetearyl alcohol | 8.00 |\\ | | Octyldodecanol | 1.00 |\\ | | Ceteareth-12 | 0.50 |\\ | | Ceteareth-20 | 0.50 |\\ | | KOH, 50% in water | 0.70 |\\ | | Toluene-2,5-diamine sulfate (oxidizing dye) | 0.90 |\\ | | Resorcinol | 0.20 |\\ | | m-Aminophenol | 0.06 |\\ | | 4-Chlororesorcinol | 0.15 |\\ | | Ascorbic acid | 0.10 |\\ | | Sodium sulfite | 0.15 |\\ | | Ammonia, 25% in water | 6.00 |\\ | | Etidronic acid | 0.20 |\\ | | Polyquaternium-2 (Mirapol A15, Rhodia) | 0.20 |\\ | | Perfume oil G2 from example 15 | 0.30 |\\ | | Water | 65.24 |\\ | | |\\ \\ - \\[0321\\]\\ \\ Part B\u2014Developer:\\ \\ - | | |\\ | --- | :-: |\\ | | Raw materials | wt % |\\ | --- | --- | --- |\\ | | |\\ | --- | :-: |\\ | |\\ \\ \\ \\ | | | |\\ | --- | --- | --- |\\ | | Cetostearyl alcohol | 8.00 |\\ | | Ceteareth-20 | 2.50 |\\ | | Steartrimonium chloride (Dehyquart B, Cognis) | 1.00 |\\ | | 2,6-Dicarboxypyridine | 0.10 |\\ | | Paraffin oil | 0.30 |\\ | | Etidronic acid | 0.40 |\\ | | Propylene glycol | 0.40 |\\ | | Sodium benzoate | 0.04 |\\ | | Hydrogen peroxide, 50% in water | 12.00 |\\ | | KOH, 50% in water, added to pH = 3.5 | q.s. |\\ | | Water | To 100 |\\ | | |\\ \\ - \\[0322\\]\\ \\ Application: The hair coloring basis according to the invention (part A) and the developer according to the invention (part B) are stirred together in a 1:1 weight ratio and applied to the hair.\\ \\ Example 26 Hair Coloring Cream for a Blonde Shade- \\[0323\\]\\ \\ - | |\\ | :-: |\\ | Part | Material | Manufacturer | INCI Name | wt % |\\ | --- | --- | --- | --- | --- |\\ | |\\ | :-: |\\ | |\\ \\ \\ \\ | | | | | |\\ | --- | --- | --- | --- | --- |\\ | A | Oxowax | LCW, France | Cetyl alcohol, | 21.00 |\\ | | | | Oleyl alcohol, |\\ | | | | Cetearyl alcohol, |\\ | | | | Stearic acid |\\ | | Volpo CS 25 | Croda GmbH, | Ceteareth25 | 4.00 |\\ | | | Germany |\\ | | Berol 175 | Brenntag eurochem | Laureth-8 | 10.00 |\\ | | | GmbH, Germany |\\ | | Lanette \u00ae E | Cognis Germany | Sodium Cetearyl | 1.00 |\\ | | | GmbH | Sulfate |\\ | | Covaquat 16 | LCW, France | Polyquaternium-6 | 4.00 |\\ | | Water | | Water (Aqua) | 49.30 |\\ | B | Ammonia (20% | Merk Eurolab | Ammonia | 10.20 |\\ | | in water) |\\ | C | Perfume oil G2 | Symrise | Perfume | 0.50 |\\ | | from example 15 |\\ | |\\ \\ - \\[0324\\]\\ \\ Method of Production:\\ \\ - \\[0325\\]\\ \\ Mix together Part A, B and C except Covaquat 16 and heat for 20 minutes at 80\u00b0 C. Once the product is homogeneous, leave to cool. Add Covaquat 16 at 50\u00b0 C. When the product begins to thicken, stop stirring. Add NH4OH at room temperature and stir the mixture until homogeneous.\\ \\ Example 27 Air Freshener Aerosol Spray, Water-Based (W/O Alcohol)- \\[0326\\]\\ \\ - | |\\ | :-: |\\ | Material | Manufacturer | INCI Name | wt % |\\ | --- | --- | --- | --- |\\ | |\\ | :-: |\\ | |\\ \\ \\ \\ | | | | |\\ | --- | --- | --- | --- |\\ | Imbentin C/125/030 | Symrise | C12-15 pareth-3 | 0.25 |\\ | Imbentin AG/100/080 | Symrise | deceth-8, Ziegler alcohol | 1.00 |\\ | Perfume oil H2 from | Symrise | Perfume | 1.25 |\\ | example 17 |\\ | Water, demineralized | | Aqua | 22.50 |\\ | Propellant gas 4.2 bar | | | 75.00 |\\ | |\\ \\ - \\[0327\\]\\ \\ Method of production: Mix together all the raw materials in the order given.\\ \\ Example 28 Liquid Air Freshener Pump-Spray- \\[0328\\]\\ \\ - | |\\ | :-: |\\ | Material | Manufacturer | INCI Name | wt % |\\ | --- | --- | --- | --- |\\ | |\\ | :-: |\\ | |\\ \\ \\ \\ | | | | |\\ | --- | --- | --- | --- |\\ | Water, demineralized | | Aqua | 90.70 |\\ | Ethanol 96% | Symrise | Ethanol | 4.00 |\\ | Empilan KCL 11/90 | Stockmeier | Alcohol C12-15 11EO | 3.00 |\\ | | Chemie GmbH |\\ | | &Co. KG |\\ | Isopropanol | Symrise | Propan-2-ol | 1.00 |\\ | Sodium hydrogen | Symrise | Sodium bicarbonate | 0.20 |\\ | carbonate p.a. |\\ | Parmetol A 26 | Hoesch Julius | Mixture of 5-chloro-2- | 0.10 |\\ | | | methyl-2H-isothiazol-3- |\\ | | | one and 2-methyl-2H- |\\ | | | isothiazol-3-one |\\ | Perfume oil F2 from | Symrise | Perfume | 1.00 |\\ | example 14 |\\ | |\\ \\ - \\[0329\\]\\ \\ Method of production: Mix together all the raw materials in the order given. Adjust the pH.\\ \\ Example 29 Deodorizing Air Freshener Pump/Wick 5% Fragrance- \\[0330\\]\\ \\ - | |\\ | :-: |\\ | Part | Material | Manufacturer | INCI Name | wt % |\\ | --- | --- | --- | --- | --- |\\ | |\\ | :-: |\\ | |\\ \\ \\ \\ | | | | | |\\ | --- | --- | --- | --- | --- |\\ | A | Water, demineralized | | Aqua | 67.32 |\\ | | Sequion 40 NA 32 | Polygon | | 1.25 |\\ | | | Chemie |\\ | | Triethanolamine pur C | Symrise | Triethanolamine | 0.30 |\\ | | Rewoderm S 1333 | Goldschmidt | DiNa-ricinoleamide of | 2.33 |\\ | | | AG | MEA-sulfosuccinate |\\ | | Tego Sorb Conc. 50 | Evonik | Alcohol C12-14, ethoxylated | 0.50 |\\ | | | | (2-5 EO) + Zn-ricinoleate |\\ | | Ethanol 96% | Symrise | Ethanol | 20.00 |\\ | B | Perfume oil E2 from example | Symrise | Perfume | 5.00 |\\ | | 13 |\\ | | Solubilizer | Symrise | | 3.00 |\\ | C | Lactic acid | Symrise | Propanoic acid, 2-hydroxy- | 0.30 |\\ | | | | propionic acid, Lactol |\\ | |\\ \\ - \\[0331\\]\\ \\ Method of production: Mix together materials of Part A in the order given. Mix together materials of Part B. When Part A is clear, add Part B. Then add Part C and stir until the mixture is homogeneous.\\ \\ Example 30 Candle- \\[0332\\]\\ \\ - | | |\\ | --- | :-: |\\ | | Material | wt % |\\ | --- | --- | --- |\\ | | |\\ | --- | :-: |\\ | |\\ \\ \\ \\ | | | |\\ | --- | --- | --- |\\ | | Candle wax | 95.00 |\\ | | Perfume oil D2 from example 12 | 5.00 |\\ | | |\\ \\ - \\[0333\\]\\ \\ Method of production: Melt the candle wax and stir. Add the perfume oil, stir well. Cast into the desired shape.\\ \\ Example 31 WC Block- \\[0334\\]\\ \\ - | |\\ | :-: |\\ | Part | Material | Manufacturer | INCI Name | wt % |\\ | --- | --- | --- | --- | --- |\\ | |\\ | :-: |\\ | |\\ \\ \\ \\ | | | | | |\\ | --- | --- | --- | --- | --- |\\ | A | Imbentin C/125/200 | Dr. W. Kolb AG | C12/15 pareth-20 | 4.00 |\\ | | Rewomid C 212 | Goldschmidt AG | Cocamide MEA | 6.00 |\\ | | Marlon ARL | Sasol GmbH | C10-13, ABS-Na, | 42.00 |\\ | | | | powder |\\ | B | Sodium sulfate | Symrise | Sodium sulfate | 42.00 |\\ | | pharm. (E514) |\\ | | Perfume oil F2 from | Symrise | Perfume | 6.00 |\\ | | example 14 |\\ | |\\ \\ - \\[0335\\]\\ \\ Method of production: Melt Part A. Mix in Part B in a mixer-kneader. Form in the extruder at 35-40\u00b0 C. to a WC block.\\ \\ Example 32 Synthesis of 3-\\[(4S)-4-isopropylcyclohexen-1-yl\\]propanal (Ib)- \\[0336\\]\\ \\ \\ \\ \\ \\ - \\[0337\\]\\ \\ The aldehyde 3-\\[(4S)-4-isopropylcyclohexen-1-yl\\]propanal (formula (Ib) as defined above) is produced starting from I-(\u2212)-limonene (79.5% ee, formula (VIb) as defined above) similarly to the synthesis of 3-\\[(4R)-4-isopropylcyclohexen-1-yl\\] propanal (Ia) (examples 4 to 8). The product is obtained with a purity of 97% and with 78% ee.\\ \\ Example 33 Substantivity- \\[0338\\]\\ \\ The substantivity test is a test for determining the sensory adherence of a substance on smelling strips. The fragrances to be investigated (compound of formula (Ia), compound of formula (Ib) and Lilial\u00ae as benchmark) are each applied in the form of a 10% solution in triethyl citrate (TEC) on a coded smelling strip by dipping and are assessed for intensity at specified time intervals by 15 testers. The 15 testers assess the odor intensity on a scale from 1=odorless to 9=very strong. The results (odor intensity I as a function of the time elapsed t in days d since dipping of the smelling strips) are in shown FIG. 1.\\ \\ - \\[0339\\]\\ \\ The odor intensity is assessed at the following time intervals after dipping of the smelling strips: 1 hour or less (shown in FIG. 1 as time point \u201c0 days\u201d); 1 day; 2 days; 3 days; 4 days; 7 days; 8 days; 9 days. To ensure that the testers are not influenced, the coded smelling strips are not arranged in a chronological order on the smelling strip stand.\\ \\ - \\[0340\\]\\ \\ The odor intensity of the compound of formula (Ia) (black filled bar) is assessed in the fresh state and for a period of up to 3 days by the testers in comparison with Lilial\u00ae (black cross-hatched bar) as stronger, and after 4 to 7 days at least comparable to Lilial\u00ae. After 9 days, a higher odor intensity of the compound of formula (Ia) compared to Lilial\u00ae is observed again.\\ \\ - \\[0341\\]\\ \\ The odor intensity of compound (Ib) (black dotted bar) is, in the fresh state, stronger than that of Lilial\u00ae (black cross-hatched bar) and after one day is comparable to Lilial\u00ae. After that, the odor intensity of the compound of formula (Ib) at first decreases more than for Lilial\u00ae and the compound of formula (Ia), but after 7 to 9 days the values are comparable or slightly higher than with Lilial\u00ae.\\ \\ \\ ### Claims (22) Hide Dependent translated from\\ \\ **1**. A compound selected from the group consisting of a compound of formula (Ia)\\ \\ \\ \\ and a compound of formula (Ib)\\ \\ \\ \\ **2**. A mixture, comprising a compound of formula (Ia) and a compound of formula (Ib), as defined in claim 1.\\ \\ **3**. A mixture according to claim 2, wherein\\ \\ the mass ratio of the compound of formula (Ia) to the compound of formula (Ib) is in the range from 0.01 to 99.99 and/or\\ \\ the total proportion of compounds of formulas (Ia) and (Ib) is greater than 0.01 wt.\\ \\ **4**. (canceled)\\ \\ **5**. (canceled)\\ \\ **6**. A fragrance preparation, comprising:\\ \\ a compound of formula (I)\\ \\ \\ \\ and\\ \\ an additional fragrance that is not a compound of formula (I).\\ \\ **7**. A fragrance preparation according to claim 6, wherein the amount of a compound of formula (Ia)\\ \\ \\ \\ and/or a compound of formula (Ib)\\ \\ \\ \\ is in the range from 0.0001 to 40 wt relative to the total weight of the fragrance preparation.\\ \\ **8**. A fragrance preparation according to claim 6 comprising an additional fragrance with an odor note of lily of the valley.\\ \\ **9**. A fragrance preparation according to claim 6, wherein\\ \\ (i) the amount of the compound of formula (Ia) is sufficient to endow the fragrance preparation with an odor note of lily of the valley,\\ \\ and/or\\ \\ (ii) an additional fragrance of the fragrance preparation imparts an odor note of lily of the valley, wherein the amount of the compound of formula (Ia) is sufficient, in comparison with a comparative fragrance preparation of otherwise identical composition without the compound of formula (Ia), to modify and/or to intensify the odor note of lily of the valley,\\ \\ and/or\\ \\ (iii) the amount of the compound of formula (Ia) is sufficient to endow the fragrance preparation with an impression selected from the group consisting of natural, caring, complex and radiant\\ \\ and/or\\ \\ (iv) the amount of the compound of formula (Ia) is sufficient to modify and/or to intensify an impression selected from the group consisting of natural, caring, complex and radiant in comparison with a comparative fragrance preparation of otherwise identical composition without the compound of formula (Ia)\\ \\ and/or\\ \\ (v) the amount of the compound of formula (Ib) is sufficient to endow the fragrance preparation with an odor note of lily of the valley,\\ \\ and/or\\ \\ (vi) an additional fragrance of the fragrance preparation imparts an odor note of lily of the valley, wherein the amount of the compound of formula (Ib) is sufficient, in comparison with a comparative fragrance preparation of otherwise identical composition without the compound of formula (Ib), to modify and/or to intensify the odor note of lily of the valley.\\ \\ **10**. A perfumed product comprising\\ \\ a compound of formula (I) as defined in claim 1 in a sensorially effective amount.\\ \\ **11**. A perfumed product according to claim 10, wherein the amount of a compound of formula (Ia) and/or a compound of formula (Ib) is in the range from 0.0001 to 5 wt %, relative to the total weight of the product.\\ \\ **12**. A perfumed product according to claim 10, selected from the group consisting of washing and cleaning products, hygiene products, and care products.\\ \\ **13**. A method for of providing skin, hair, surfaces, or textile fibers with an odor note of lily of the valley comprising applying a fragrance preparation according to claim 6 to the skin, hair, surfaces, or textile fibers.\\ \\ **14**. A method for producing the compound of formula (I)\\ \\ \\ \\ comprising an acid-catalyzed reaction of an acetal of formula (II),\\ \\ \\ \\ wherein R is a linear or branched, saturated or unsaturated alkyl group with 1 to 10 carbon atoms.\\ \\ **15**. An acetal of formula (II)\\ \\ \\ \\ wherein R is a linear or branched, saturated or unsaturated alkyl group with 1 to 10 carbon atoms.\\ \\ **16**. A method for producing a compound of formula (Ia) or a compound of formula (Ib) as defined in claim 1, or a mixture of compounds of formula (Ia) and (Ib), comprising the use\\ \\ of d-(+) limonene as educt for producing the compound of formula (Ia),\\ \\ of 1-(\u2212) limonene as educt for producing the compound of formula (Ib) as, or\\ \\ of a mixture containing d-(+) limonene and 1-(\u2212) limonene as educt for producing a mixture containing the compound of formula (Ia) and the compound of formula (Ib).\\ \\ **17**. A method for producing a compound of formula (I) as defined in claim 6 comprising pyrolysis of the spirolactone of formula (VIII) to form the compound of formula (I)\\ \\ \\ \\ **18**. A method for mediating, intensifying and/or modifying an odor note of lily of the valley to a substance comprising bringing the substance into contact with a compound according to claim 1.\\ \\ a compound of formula (I),\\ \\ **19**. A method for mediating, intensifying and/or modifying an odor note of lily of the valley to a substance comprising bringing the substance into contact with a mixture according to claim 2.\\ \\ **20**. A method for mediating, intensifying and/or modifying an odor note of lily of the valley to a substance comprising bringing the substance into contact with a fragrance preparation according to claim 6.\\ \\ **21**. A method for mediating, intensifying and/or modifying an odor note of lily of the valley to a substance comprising bringing the substance into contact with a fragrance preparation according to claim 7.\\ \\ **22**. A method for increasing the sub stantivity and/or the retention of a fragrance comprising combining the fragrance with a compound of formula (I) as defined in claim 6."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": null, "compound_ref_verbatim": null, "confidence": 0.45, "construct": {"method_text_verbatim": "\u201cStandard\u201d systems refer to those that are \u201cpre-loaded\u201d with the intent of keeping the pre-loaded perfume associated with the polymer until the moment or moments of perfume release. Such polymers may also suppress the neat product odor and provide a bloom and/or longevity benefit depending on the rate of perfume release. One challenge with such systems is to achieve the ideal balance between 1) in-product stability (keeping perfume inside carrier until you need it) and 2) timely release (during use or from dry situs). Achieving such stability is particularly important during in-product storage and product aging. This challenge is particularly apparent for aqueous-based, surfactant-containing products, such as heavy duty liquid laundry detergents. Many \u201cStandard\u201d matrix systems available effectively become \u201cEquilibrium\u201d systems when formulated into aqueous-based products. One may select an \u201cEquilibrium\u201d system or a Reservoir system, which has acceptable in-product diffusion stability an", "panel_size": null, "property_name": "odor_intensity", "scale": "numeric_unknown", "substrate": null, "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "2005/0003980; 2004/0110648; 2004/0092414; 2004/0091445; 2004/0087476", "patent_id": "US9822327B2", "provenance": {"citation": "US9822327B2", "retrieval_source": "Firecrawl scrape of Google Patents public page", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US9822327B2/en"}, "pub_date": null, "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description_translated_from:305", "units": "ordinal_ratio", "verbatim_quote": "\u201cStandard\u201d systems refer to those that are \u201cpre-loaded\u201d with the intent of keeping the pre-loaded perfume associated with the polymer until the moment or moments of perfume release. Such polymers may also suppress the neat product odor and provide a bloom and/or longevity benefit depending on the rate of perfume release. One challenge with such systems is to achieve the ideal balance between 1) in-product stability (keeping perfume inside carrier until you need it) and 2) timely release (during use or from dry situs). Achieving such stability is particularly important during in-product storage and product aging. This challenge is particularly apparent for aqueous-based, surfactant-containing products, such as heavy duty liquid laundry detergents. Many \u201cStandard\u201d matrix systems available effectively become \u201cEquilibrium\u201d systems when formulated into aqueous-based products. One may select an \u201cEquilibrium\u201d system or a Reservoir system, which has acceptable in-product diffusion stability and available triggers for release (e.g., friction). \u201cEquilibrium\u201d systems are those in which the perfume and polymer may be added separately to the product, and the equilibrium interaction between perfume and polymer leads to a benefit at one or more consumer touch points (versus a free perfume control that has no polymer-assisted delivery technology). The polymer may also be pre-loaded with perfume; however, part or all of the perfume may diffuse during in-product storage reaching an equilibrium that includes having desired perfume raw materials (PRMs) associated with the polymer. The polymer then carries the perfume to the surface, and release is typically via perfume diffusion. The use of such equilibrium system polymers has the potential to decrease the neat product odor intensity of the neat product (usually more so in the case of pre-loaded standard system). Deposition of such polymers may serve to \u201cflatten\u201d the release profile and provide increased longevity. As indicated above, such longevity would be achieved by suppressing the initial intensity and may enable the formulator to use more high impact or low odor detection threshold (ODT) or low Kovats Index (KI) PRMs to achieve FMOT benefits without initial intensity that is too strong or distorted. It is important that perfume release occurs within the time frame of the application to impact the desired consumer touch point or touch points. Suitable micro-particles and micro-latexes as well as methods of making same may be found in USPA 2005/0003980 A1. Matrix systems also include hot melt adhesives and perfume plastics. In addition, hydrophobically modified polysaccharides may be formulated into the perfumed product to increase perfume deposition and/or modify perfume release. All such matrix systems, including for example polysaccarides and nanolatexes may be combined with other PDTs, including other PAD systems such as PAD reservoir systems in the form of a perfume microcapsule (PMC). Polymer Assisted Delivery (PAD) matrix systems may include those described in the following references: US Patent Applications 2004/0110648 A1; 2004/0092414 A1; 2004/0091445 A1 and 2004/0087476 A1; and U.S. Pat. Nos. 6,531,444; 6,024,943; 6,042,792; 6,051,540; 4,540,721 and 4,973,422."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": null, "compound_ref_verbatim": null, "confidence": 0.45, "construct": {"method_text_verbatim": "IV. Amine Assisted Delivery (AAD): The amine-assisted delivery technology approach utilizes materials that contain an amine group to increase perfume deposition or modify perfume release during product use. There is no requirement in this approach to pre-complex or pre-react the perfume raw material(s) and amine prior to addition to the product. In one aspect, amine-containing AAD materials suitable for use herein may be non-aromatic; for example, polyalkylimine, such as polyethyleneimine (PEI), or polyvinylamine (PVAm), or aromatic, for example, anthranilates. Such materials may also be polymeric or non-polymeric. In one aspect, such materials contain at least one primary amine. This technology will allow increased longevity and controlled release also of low ODT perfume notes (e.g., aldehydes, ketones, enones) via amine functionality, and delivery of other PRMs, without being bound by theory, via polymer-assisted delivery for polymeric amines. Without technology, volatile top notes c", "panel_size": null, "property_name": "longevity", "scale": "numeric_unknown", "substrate": null, "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "2005/0003980; 2003/0199422; 2003/0036489; 2004/0220074", "patent_id": "US9822327B2", "provenance": {"citation": "US9822327B2", "retrieval_source": "Firecrawl scrape of Google Patents public page", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US9822327B2/en"}, "pub_date": null, "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description_translated_from:310", "units": "ordinal_ratio", "verbatim_quote": "IV. Amine Assisted Delivery (AAD): The amine-assisted delivery technology approach utilizes materials that contain an amine group to increase perfume deposition or modify perfume release during product use. There is no requirement in this approach to pre-complex or pre-react the perfume raw material(s) and amine prior to addition to the product. In one aspect, amine-containing AAD materials suitable for use herein may be non-aromatic; for example, polyalkylimine, such as polyethyleneimine (PEI), or polyvinylamine (PVAm), or aromatic, for example, anthranilates. Such materials may also be polymeric or non-polymeric. In one aspect, such materials contain at least one primary amine. This technology will allow increased longevity and controlled release also of low ODT perfume notes (e.g., aldehydes, ketones, enones) via amine functionality, and delivery of other PRMs, without being bound by theory, via polymer-assisted delivery for polymeric amines. Without technology, volatile top notes can be lost too quickly, leaving a higher ratio of middle and base notes to top notes. The use of a polymeric amine allows higher levels of top notes and other PRMS to be used to obtain freshness longevity without causing neat product odor to be more intense than desired, or allows top notes and other PRMs to be used more efficiently. In one aspect, AAD systems are effective at delivering PRMs at pH greater than about neutral. Without wishing to be bound by theory, conditions in which more of the amines of the AAD system are deprotonated may result in an increased affinity of the deprotonated amines for PRMs such as aldehydes and ketones, including unsaturated ketones and enones such as damascone. In another aspect, polymeric amines are effective at delivering PRMs at pH less than about neutral. Without wishing to be bound by theory, conditions in which more of the amines of the AAD system are protonated may result in a decreased affinity of the protonated amines for PRMs such as aldehydes and ketones, and a strong affinity of the polymer framework for a broad range of PRMs. In such an aspect, polymer-assisted delivery may be delivering more of the perfume benefit; such systems are a subspecies of AAD and may be referred to as Amine-Polymer-Assisted Delivery or APAD. In some cases when the APAD is employed in a composition that has a pH of less than seven, such APAD systems may also be considered Polymer-Assisted Delivery (PAD). In yet another aspect, AAD and PAD systems may interact with other materials, such as anionic surfactants or polymers to form coacervate and/or coacervates-like systems. In another aspect, a material that contains a heteroatom other than nitrogen, for example sulfur, phosphorus or selenium, may be used as an alternative to amine compounds. In yet another aspect, the aforementioned alternative compounds can be used in combination with amine compounds. In yet another aspect, a single molecule may comprise an amine moiety and one or more of the alternative heteroatom moieties, for example, thiols, phosphines and selenols. Suitable AAD systems as well as methods of making same may be found in US Patent Applications 2005/0003980 A1; 2003/0199422 A1; 2003/0036489 A1; 2004/0220074 A1 and U.S. Pat. No. 6,103,678."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": null, "compound_ref_verbatim": null, "confidence": 0.45, "construct": {"method_text_verbatim": "VI. Starch Encapsulated Accord (SEA): The use of a starch encapsulated accord (SEA) technology allows one to modify the properties of the perfume, for example, by converting a liquid perfume into a solid by adding ingredients such as starch. The benefit includes increased perfume retention during product storage, especially under non-aqueous conditions. Upon exposure to moisture, a perfume bloom may be triggered. Benefits at other moments of truth may also be achieved because the starch allows the product formulator to select PRMs or PRM concentrations that normally cannot be used without the presence of SEA. Another technology example includes the use of other organic and inorganic materials, such as silica to convert perfume from liquid to solid. Suitable SEAs as well as methods of making same may be found in USPA 2005/0003980 A1 and U.S. Pat. No. 6,458,754 B1.", "panel_size": null, "property_name": "retention", "scale": "numeric_unknown", "substrate": null, "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "2005/0003980", "patent_id": "US9822327B2", "provenance": {"citation": "US9822327B2", "retrieval_source": "Firecrawl scrape of Google Patents public page", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US9822327B2/en"}, "pub_date": null, "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description_translated_from:312", "units": "ordinal_ratio", "verbatim_quote": "VI. Starch Encapsulated Accord (SEA): The use of a starch encapsulated accord (SEA) technology allows one to modify the properties of the perfume, for example, by converting a liquid perfume into a solid by adding ingredients such as starch. The benefit includes increased perfume retention during product storage, especially under non-aqueous conditions. Upon exposure to moisture, a perfume bloom may be triggered. Benefits at other moments of truth may also be achieved because the starch allows the product formulator to select PRMs or PRM concentrations that normally cannot be used without the presence of SEA. Another technology example includes the use of other organic and inorganic materials, such as silica to convert perfume from liquid to solid. Suitable SEAs as well as methods of making same may be found in USPA 2005/0003980 A1 and U.S. Pat. No. 6,458,754 B1."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": null, "compound_ref_verbatim": null, "confidence": 0.45, "construct": {"method_text_verbatim": "VIII. Pro-Perfume (PP): This technology refers to perfume technologies that result from the reaction of perfume materials with other substrates or chemicals to form materials that have a covalent bond between one or more PRMs and one or more carriers. The PRM is converted into a new material called a pro-PRM (i.e., pro-perfume), which then may release the original PRM upon exposure to a trigger such as water or light. Pro-perfumes may provide enhanced perfume delivery properties such as increased perfume deposition, longevity, stability, retention, and the like. Pro-perfumes include those that are monomeric (non-polymeric) or polymeric, and may be pre-formed or may be formed in-situ under equilibrium conditions, such as those that may be present during in-product storage or on the wet or dry situs. Nonlimiting examples of pro-perfumes include Michael adducts (e.g., beta-amino ketones), aromatic or non-aromatic imines (Schiff bases), oxazolidines, beta-keto esters, and orthoesters. Anot", "panel_size": null, "property_name": "longevity", "scale": "numeric_unknown", "substrate": null, "time_points": null}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "2006/0020459; 2005/0003980; 2006/0223726", "patent_id": "US9822327B2", "provenance": {"citation": "US9822327B2", "retrieval_source": "Firecrawl scrape of Google Patents public page", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US9822327B2/en"}, "pub_date": null, "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description_translated_from:314", "units": "ordinal_ratio", "verbatim_quote": "VIII. Pro-Perfume (PP): This technology refers to perfume technologies that result from the reaction of perfume materials with other substrates or chemicals to form materials that have a covalent bond between one or more PRMs and one or more carriers. The PRM is converted into a new material called a pro-PRM (i.e., pro-perfume), which then may release the original PRM upon exposure to a trigger such as water or light. Pro-perfumes may provide enhanced perfume delivery properties such as increased perfume deposition, longevity, stability, retention, and the like. Pro-perfumes include those that are monomeric (non-polymeric) or polymeric, and may be pre-formed or may be formed in-situ under equilibrium conditions, such as those that may be present during in-product storage or on the wet or dry situs. Nonlimiting examples of pro-perfumes include Michael adducts (e.g., beta-amino ketones), aromatic or non-aromatic imines (Schiff bases), oxazolidines, beta-keto esters, and orthoesters. Another aspect includes compounds comprising one or more beta-oxy or beta-thio carbonyl moieties capable of releasing a PRM, for example, an alpha, beta-unsaturated ketone, aldehyde or carboxylic ester. The typical trigger for perfume release is exposure to water; although other triggers may include enzymes, heat, light, pH change, autoxidation, a shift of equilibrium, change in concentration or ionic strength and others. For aqueous-based products, light-triggered pro-perfumes are particularly suited. Such photo-pro-perfumes (PPPs) include but are not limited to those that release coumarin derivatives and perfumes and/or pro-perfumes upon being triggered. The released pro-perfume may release one or more PRMs by means of any of the above mentioned triggers. In one aspect, the photo-pro-perfume releases a nitrogen-based pro-perfume when exposed to a light and/or moisture trigger. In another aspect, the nitrogen-based pro-perfume, released from the photo-pro-perfume, releases one or more PRMs selected, for example, from aldehydes, ketones (including enones) and alcohols. In still another aspect, the PPP releases a dihydroxy coumarin derivative. The light-triggered pro-perfume may also be an ester that releases a coumarin derivative and a perfume alcohol. In one aspect the pro-perfume is a dimethoxybenzoin derivative as described in USPA 2006/0020459 A1. In another aspect the pro-perfume is a 3\u2032, 5\u2032-dimethoxybenzoin (DMB) derivative that releases an alcohol upon exposure to electromagnetic radiation. In yet another aspect, the pro-perfume releases one or more low ODT PRMs, including tertiary alcohols such as linalool, tetrahydrolinalool, or dihydromyrcenol. Suitable pro-perfumes and methods of making same can be found in U.S. Pat. Nos. 7,018,978 B2; 6,987,084 B2; 6,956,013 B2; 6,861,402 B1; 6,544,945 B1; 6,093,691; 6,277,796 B1; 6,165,953; 6,316,397 B1; 6,437,150 B1; 6,479,682 B1; 6,096,918; 6,218,355 B1; 6,133,228; 6,147,037; 7,109,153 B2; 7,071,151 B2; 6,987,084 B2; 6,610,646 B2 and 5,958,870, as well as can be found in USPA 2005/0003980 A1 and USPA 2006/0223726 A1."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": null, "compound_ref_verbatim": null, "confidence": 0.75, "construct": {"method_text_verbatim": "Solid-Phase Micro-Extraction (SPME)-Gas Chromatography/Mass Spectrometry is used to measure the level of perfume raw materials in the headspace of products. 1.0 grams of the 1 week at 40 degrees Centigrade aged sample (shampoo or conditioner) are placed into a clean 20 ml headspace vial and allowed to equilibrate for at least 2 hours at room temperature.", "panel_size": null, "property_name": "headspace_concentration_or_intensity", "scale": "hours_or_timepoint", "substrate": ["headspace"], "time_points": ["2 hours"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "2 hours", "patent_id": "US9822327B2", "provenance": {"citation": "US9822327B2", "retrieval_source": "Firecrawl scrape of Google Patents public page", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US9822327B2/en"}, "pub_date": null, "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description_translated_from:352", "units": "hours", "verbatim_quote": "Solid-Phase Micro-Extraction (SPME)-Gas Chromatography/Mass Spectrometry is used to measure the level of perfume raw materials in the headspace of products. 1.0 grams of the 1 week at 40 degrees Centigrade aged sample (shampoo or conditioner) are placed into a clean 20 ml headspace vial and allowed to equilibrate for at least 2 hours at room temperature."}
{"alignment_to_poucher": {"correlation": null, "overlap_n": null}, "assignee": null, "compound_ref_verbatim": null, "confidence": 0.75, "construct": {"method_text_verbatim": "Analysis Procedure: - 1\\. Transfer sample to proper sample tray and proceed with SPME-GC-MS analysis. - 2\\. Start sequence of sample loading and analysis. In this step, the sample is allowed to equilibrate for at least two hours on the auto sampler tray, then sampled directly from the tray. The SPME fiber assembly is DVB/CAR/PDMS (50/30 um, 24 ga, 1 cm length). Sampling time is 5 minutes. - 3\\. Injector temperature is at 260 C. - 4\\. Then GC-MS analysis run is started. Desportion time is 5 minutes. - 5\\. The following temperature program is used: - i) an initial temperature of about 50\u00b0 C. which is held for 3 minutes, - ii) increase the initial temperature at a rate of about 6\u00b0 C./min until a temperature of about 250\u00b0 C. is reached, then 25\u00b0 C./min to 275\u00b0 C., hold at about 275\u00b0 C. for 4.67 minute. - 6\\. Perfume compounds are identified using the MS spectral libraries of John Wiley & Sons and the National Institute of Standards and Technology (NIST), purchased and licensed through Hewl", "panel_size": null, "property_name": "headspace_concentration_or_intensity", "scale": "hours_or_timepoint", "substrate": ["headspace"], "time_points": ["5 minutes", "3 minutes", "4.67 minute"]}, "construct_group_id": null, "dedup_tag": null, "extraction_method": "regex_span_probe", "measured_value_verbatim": "50/30; 5 minutes; 3 minutes; 4.67 minute", "patent_id": "US9822327B2", "provenance": {"citation": "US9822327B2", "retrieval_source": "Firecrawl scrape of Google Patents public page", "tos_note": "Fetched public patent page; stored extracted spans only, not bulk full text.", "url": "https://patents.google.com/patent/US9822327B2/en"}, "pub_date": null, "resolution_confidence": 0.0, "resolution_method": "unresolved", "resolved_cas": null, "resolved_smiles": null, "source_locus": "description_translated_from:355", "units": "ordinal_ratio", "verbatim_quote": "Analysis Procedure: - 1\\. Transfer sample to proper sample tray and proceed with SPME-GC-MS analysis. - 2\\. Start sequence of sample loading and analysis. In this step, the sample is allowed to equilibrate for at least two hours on the auto sampler tray, then sampled directly from the tray. The SPME fiber assembly is DVB/CAR/PDMS (50/30 um, 24 ga, 1 cm length). Sampling time is 5 minutes. - 3\\. Injector temperature is at 260 C. - 4\\. Then GC-MS analysis run is started. Desportion time is 5 minutes. - 5\\. The following temperature program is used: - i) an initial temperature of about 50\u00b0 C. which is held for 3 minutes, - ii) increase the initial temperature at a rate of about 6\u00b0 C./min until a temperature of about 250\u00b0 C. is reached, then 25\u00b0 C./min to 275\u00b0 C., hold at about 275\u00b0 C. for 4.67 minute. - 6\\. Perfume compounds are identified using the MS spectral libraries of John Wiley & Sons and the National Institute of Standards and Technology (NIST), purchased and licensed through Hewlett Packard. - 7\\. Chromatographic peaks for specific ions are integrated using the Chemstation software obtained from Agilent Technologies, Inc., Wilmington, Del., USA. - 8\\. The ratio for each PRM is calculated by dividing the peak area for the perfume raw material in Sample A by the peak area in Sample B. - 9\\. Each ratio is then weighted by that perfume raw material's weight composition in the perfume. - 10\\. The Headspace Ratio is calculated as the sum of the individual perfume raw material ratios obtained in step 9."}