---
library_name: pyaging
tags:
- pyaging
- aging-clock
- biology
- dna-methylation
---

# yingdamage

Causality-enriched age predictor restricted to damaging age-related CpGs, with feature penalties weighted by EWMR causality scores.

Model weights retain the original authors' terms; the pyaging software license does not relicense them.

| | |
|---|---|
| **Predicts** | damaging epigenetic age |
| **Species** | Homo sapiens |
| **Tissue** | whole blood |
| **Data type** | DNA methylation |
| **Model type** | causality-weighted elastic net regression |
| **Year** | 2024 |

## Use with pyaging

```python
import pyaging as pya

pya.pred.predict_age(adata, ["yingdamage"])
```

Browse every clock in the [pyaging Clock Catalogue](https://pyaging.readthedocs.io).

## Citation

Ying, K., Liu, H., Tarkhov, A.E. et al. Causality-enriched epigenetic age uncouples damage and adaptation. Nature Aging 4, 231–246 (2024).

https://doi.org/10.1038/s43587-023-00557-0