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Data Constants - SUD Categories, Drug/Project Templates, Synthetic Data Settings
All data generation and template related constants
"""
# ========================================
# SUD CATEGORIES (Used in generate_synthetic_data)
# ========================================
SUD_CATEGORY_DESCRIPTIONS = {
"Opioid-Related Disorders": "Addiction to opioids including prescription painkillers, heroin, and fentanyl",
"Alcohol Use Disorder": "Problematic pattern of alcohol use leading to clinically significant impairment",
"Stimulant Use Disorder": "Addiction to cocaine, methamphetamine, or prescription stimulants",
"Cannabis Use Disorder": "Problematic cannabis use with withdrawal and tolerance symptoms",
"Sedative/Hypnotic Disorder": "Dependence on benzodiazepines or other sedative medications",
"Nicotine Use Disorder": "Tobacco/nicotine dependence and addiction",
}
SUD_CATEGORY_COLORS = {
"Opioid-Related Disorders": "#1E6B52",
"Alcohol Use Disorder": "#008C95",
"Stimulant Use Disorder": "#5A9B7F",
"Cannabis Use Disorder": "#16533E",
"Sedative/Hypnotic Disorder": "#4A8B7A",
"Nicotine Use Disorder": "#2C7A64",
}
DISEASE_SEARCH_CONFIG = {
"Opioid-Related Disorders": {
"search_terms": ["Opioid-Related Disorders"],
},
"Alcohol Use Disorder": {
"search_terms": ["Alcoholism"],
},
"Stimulant Use Disorder": {
"search_terms": ["Stimulant Use Disorder"],
},
"Cannabis Use Disorder": {
"search_terms": ["Cannabis Use Disorder"],
},
"Nicotine Use Disorder": {
"search_terms": ["Tobacco Use Disorder"],
},
"Sedative/Hypnotic Disorder": {
"search_terms": ["Sedative/Hypnotic Disorder"],
},
}
# ========================================
# DRUG TEMPLATES (Used in generate_synthetic_data)
# ========================================
DRUG_TEMPLATES = {
"Opioid-Related Disorders": [
("Naltrexone", "Alcohol/opioid dependence", "μ-opioid receptor antagonist", "S5"),
("Buprenorphine", "Opioid dependence", "Partial μ-opioid agonist", "S6"),
("Lofexidine", "Hypertension", "α2-adrenergic agonist", "S4"),
("Gabapentin", "Epilepsy, neuropathic pain", "GABA analog", "S4"),
("Topiramate", "Epilepsy, migraine", "GABA modulator", "S3"),
("Ondansetron", "Nausea/vomiting", "5-HT3 antagonist", "S2"),
("Clonidine", "Hypertension", "α2-adrenergic agonist", "S3"),
("Memantine", "Alzheimer's disease", "NMDA antagonist", "S2"),
("Prazosin", "Hypertension", "α1-adrenergic antagonist", "S1"),
("Mirtazapine", "Depression", "α2-adrenergic antagonist", "S2"),
],
"Alcohol Use Disorder": [
("Acamprosate", "Alcohol dependence", "NMDA antagonist", "S5"),
("Naltrexone", "Opioid dependence", "μ-opioid antagonist", "S5"),
("Baclofen", "Muscle spasticity", "GABA-B agonist", "S4"),
("Topiramate", "Epilepsy", "GABA modulator", "S4"),
("Varenicline", "Smoking cessation", "Nicotinic receptor agonist", "S3"),
("Ondansetron", "Nausea/vomiting", "5-HT3 antagonist", "S3"),
("Gabapentin", "Epilepsy", "GABA analog", "S2"),
("Zonisamide", "Epilepsy", "Carbonic anhydrase inhibitor", "S1"),
],
"Stimulant Use Disorder": [
("Modafinil", "Narcolepsy", "Dopamine reuptake inhibitor", "S4"),
("Bupropion", "Depression", "NDRI", "S4"),
("Topiramate", "Epilepsy", "GABA modulator", "S3"),
("N-acetylcysteine", "Acetaminophen overdose", "Antioxidant", "S3"),
("Mirtazapine", "Depression", "α2-antagonist", "S2"),
("Atomoxetine", "ADHD", "NRI", "S1"),
],
"Cannabis Use Disorder": [
("N-acetylcysteine", "Acetaminophen overdose", "Antioxidant", "S3"),
("Gabapentin", "Epilepsy", "GABA analog", "S3"),
("Zolpidem", "Insomnia", "GABA-A modulator", "S2"),
("Dronabinol", "Nausea/vomiting", "CB1 agonist", "S2"),
("Buspirone", "Anxiety", "5-HT1A agonist", "S1"),
],
"Sedative/Hypnotic Disorder": [
("Flumazenil", "Benzodiazepine overdose", "GABA-A antagonist", "S3"),
("Gabapentin", "Epilepsy", "GABA analog", "S3"),
("Pregabalin", "Neuropathic pain", "GABA analog", "S2"),
],
"Nicotine Use Disorder": [
("Varenicline", "Smoking cessation", "Nicotinic receptor agonist", "S6"),
("Cytisine", "Smoking cessation (EU)", "Nicotinic receptor agonist", "S5"),
("Bupropion", "Depression", "NDRI", "S5"),
("Naltrexone", "Opioid dependence", "μ-opioid antagonist", "S4"),
],
}
# ========================================
# PROJECT TEMPLATES (Used in generate_synthetic_data)
# ========================================
PROJECT_TEMPLATES = [
{
"name": "NIDA Clinical Trial NCT02892123",
"type": "Clinical Trial",
"size_range": (150, 500),
"impact_range": (0.10, 0.20),
"summary": "Randomized controlled trial showing significant reduction in relapse rates"
},
{
"name": "Meta-Analysis Lee et al. 2024",
"type": "Meta-Analysis",
"size_range": (800, 3000),
"impact_range": (0.08, 0.15),
"summary": "Pooled analysis of multiple RCTs demonstrating efficacy across populations"
},
{
"name": "RWE Claims Database Analysis",
"type": "Real-World Evidence",
"size_range": (2000, 10000),
"impact_range": (0.05, 0.12),
"summary": "Insurance claims data showing real-world treatment adherence and outcomes"
},
{
"name": "Biomarker Validation Study",
"type": "Biomarker Study",
"size_range": (50, 200),
"impact_range": (0.06, 0.10),
"summary": "Identification of predictive biomarkers for treatment response"
},
{
"name": "Phase II Safety Trial",
"type": "Clinical Trial",
"size_range": (100, 300),
"impact_range": (0.07, 0.13),
"summary": "Safety and tolerability data in target SUD population"
},
{
"name": "Safety Concern Report FDA-2024",
"type": "Safety Analysis",
"size_range": (80, 250),
"impact_range": (-0.15, -0.08),
"summary": "Adverse event reports indicating potential safety concerns in target population"
},
{
"name": "Negative RCT Results Study",
"type": "Clinical Trial",
"size_range": (120, 400),
"impact_range": (-0.12, -0.06),
"summary": "Randomized trial showing no significant efficacy compared to placebo"
},
]
# ========================================
# METRICS & ANALYTICS (Used in analytics functions)
# ========================================
AVERAGE_TIME_TO_IND = 12.7 # months
CURRENT_IND_READY_COUNT = 2
TIME_BINS_LABELS = ['6-9', '9-12', '12-15', '15-18', '18-21', '21-24', '24+']
TIME_BINS_COUNTS = [10, 16, 25, 31, 39, 42, 49]
QUARTERLY_DELIVERIES = [
{'quarter': 'Sep 2025', 'year': 2025, 'count': 0, 'cumulative': 0},
{'quarter': 'Jan 2026', 'year': 2026, 'count': 0.5, 'cumulative': 0.5},
{'quarter': 'Apr 2026', 'year': 2026, 'count': 0.3, 'cumulative': 0.8},
{'quarter': 'Jun 2026', 'year': 2026, 'count': 1.2, 'cumulative': 2.0},
{'quarter': 'Sep 2026', 'year': 2026, 'count': 0, 'cumulative': 2.0},
] |