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| The Applied Proteogenomics Organizational Learning and Outcomes | |
| (APOLLO) network is a collaboration between NCI, the Department of | |
| Defense (DoD), and the Department of Veterans Affairs (VA) to | |
| incorporate proteogenomics into patient care as a way of looking | |
| beyond the genome, to the activity and expression of the proteins that | |
| the genome encodes. The emerging field of proteogenomics aims to | |
| better predict how patients will respond to therapy by screening their | |
| tumors for both genetic abnormalities and protein information, an | |
| approach that has been made possible in recent years due to advances | |
| in proteomic technology. | |
| The APOLLO network collects data that include a full set of medical | |
| images, including CT and MRI scans, obtained before and during | |
| treatment. Each set of images can be connected to the patient’s | |
| genomic, proteomic, and clinical data. The real data will be made | |
| available publicly through the Genomic Data Commons, Proteomics Data | |
| Commons, and Cancer Imaging Archive. By using all available data, | |
| researchers will be able to study the relationships among these data, | |
| validate results, and develop predictive and prognostic models to | |
| improve patient care. Aligning this data with the NCI Cancer Research | |
| Data Commons is currently a time intensive manual effort. | |