The manuscript in which this dataset is used correlates patient survival with morphologic imaging features and hemodynamic parameters obtained from the non-enhancing region (NER) of glioblastoma (GBM), along with clinical and genomic markers. Forty-five patients with GBM underwent baseline imaging with contrast material-enhanced magnetic resonance (MR) imaging and dynamic susceptibility contrast-enhanced T2*-weighted perfusion MR imaging. Molecular and clinical predictors of survival were obtained. Single and multivariable models of overall survival (OS) and progression-free survival (PFS) were explored with Kaplan-Meier estimates, Cox regression, and random survival forests. This dataset correlates with images on the TCIA web portal and includes supplemental data including clinical, genomic, and radiologist derived information from JainPoisson_2014_Radiology_Dataset.xlsx. The xlsx file contains 2 sheets: the dataset, and a second worksheet of descriptions of the variables.