,fname,start,end,text,n_tokens,embeddings
1,Essential Oils and The Brain Module 5,0.0,171.8,"You don't hand out the materials in any way. Direct them to starfishsense.com to get the class materials if they'd like to have the permanent materials. But you're welcome to teach a class with it if you'd like to. Hello. So if you're jumping on, say hi. Good to see everybody. So we're going to go ahead and get started. Just a couple announcements first. So I am running another course right now, a series on CBD, cannabidiol, oil, which everyone is excited about and wants to know more information about. So I put together a very scientifically oriented class series on the science of CBD. How does it work? What does it do? All the considerations about CBD that you need to know. We just finished up the third module. So the series is complete. There's three modules, each about an hour long. You get all the slides and all the video. I will post in this group instructions on how to order.",201,"[-0.005926778074353933, 0.007059541065245867, -0.006054888013750315, -0.030099133029580116, -0.02880454622209072, -0.003071271348744631, -0.013599899597465992, -0.011266946792602539, -0.02430046536028385, 0.01316162757575512, 0.009203699417412281, 0.016209300607442856, -0.009722882881760597, 0.017234180122613907, 0.007511297706514597, 0.0017547713359817863, 0.04056370630860329, -0.005640216171741486, 0.0046052210964262486, 0.0017092585330829024, -0.007518040481954813, 0.010471316054463387, -0.0101004708558321, -0.0020581900607794523, -0.01055222749710083, 0.0002237712760688737, 0.014928198419511318, -0.0059402636252343655, -0.009250897914171219, -0.030584601685404778, 0.005292970221489668, 0.034063804894685745, -0.008212531916797161, -0.008010253310203552, -0.0023413808085024357, -0.0037185645196586847, 0.007875400595366955, 0.013943773694336414, 0.011287175118923187, -0.013694296590983868, 0.024637596681714058, 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2,Essential Oils and The Brain Module 5,178.28,269.24,"Again, it's through a Facebook group. You get all the videos and you get links to the slides and the videos that you can use. And you can teach your own class with the material as well. I'm also putting all of this essential oils in the brain as a DVD set. So if you want to get the DVD set, link is at the top of this post in the video header where the video is being posted in the group. There's a link to buy the DVDs for the entire series so you can have permanent record at home to show this to someone else. So let's go ahead and get started. We're going to talk about neurodegenerative disorders in this module. Dementia, Alzheimer's, those types of things where the brain is degenerating over time and there's different causes for that but the outcome is normally the same. 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3,Essential Oils and The Brain Module 5,274.08,390.0,"neural tissue. The prime suspect is a protein called beta amyloid which is derived from a precursor protein called amyloid precursor protein, APP, which is in the brain. It's a normal protein that our brain cells need and they use for normal function and this big long protein APP is a precursor meaning that it gets chopped up into smaller pieces and then those smaller pieces each have a different function. Well one of those smaller pieces that get chopped up from APP is called beta amyloid. It's a smaller fragment of the bigger APP protein molecule and that beta amyloid, that smaller peptide or that smaller sequence from the larger protein basically gets, it's very sticky and it wants to bind to itself and form structures where they become insoluble and they precipitate out and then create these larger structures called fibrils.",163,"[-0.012119881808757782, 0.004046550951898098, 0.00831717811524868, -0.010538168251514435, -0.008995996788144112, 0.013266623951494694, 0.0034632941242307425, 0.000526414078194648, -0.024938352406024933, -0.005565655417740345, -0.002660903846845031, -0.0001995677885133773, 0.0064817313104867935, 0.029472598806023598, -0.007585635408759117, 0.0021781516261398792, 0.01975824125111103, 0.041440900415182114, -0.009246435016393661, 0.023607077077031136, -0.028787190094590187, 0.016924336552619934, -0.0012085281778126955, -0.015184451825916767, 0.0021254278253763914, -0.0034599988721311092, 0.013550014235079288, -0.03804021701216698, 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4,Essential Oils and The Brain Module 5,397.8,548.44,"So basically the way it progresses is the amyloid peptide basically forms first oligomers when they bind together and then the oligomers get together for clusters called fibrils and then the fibrils form mats that form beta sheets and then basically that forms a plaque. So these plaques form in the brain, they precipitate out, you can actually see them under a microscope and then these plaques basically recruit immune cells to the site. So immune cells of our body start to go to the site. The immune cells generate oxidative stress as well in the brain and basically the immune system starts to attack that area of brain tissue, triggers inflammation in the brain. Basically the brain cells end up dying from this whole process. There's a lot of oxidative stress meaning that there's reactive oxidative species that are generated here that generate more neurotoxicity and cell death.",171,"[-0.021319927647709846, -0.0001726973569020629, -0.008928363211452961, -0.024615760892629623, -0.022954968735575676, 0.01358244102448225, -0.0007861400954425335, -0.006134628783911467, -0.024216655641794205, -0.011322992853820324, 0.019968120381236076, -0.0027020045090466738, 0.006141066085547209, 0.025104986503720284, -0.009308156557381153, -0.008168776519596577, 0.023070838302373886, 0.025220856070518494, -0.010782269760966301, 0.007518621627241373, -0.03540446609258652, 0.008200962096452713, 0.018178584054112434, -0.010762957856059074, 0.025117861106991768, -0.0014934248756617308, -0.009391839616000652, -0.035224225372076035, -0.013505195267498493, -0.0013888207031413913, 0.003765747882425785, -0.0025716517120599747, -0.016195934265851974, -0.0010830548126250505, 0.0016084893140941858, 0.0033956102561205626, 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5,Essential Oils and The Brain Module 5,561.24,664.28,"rest of the tissue of the brain and cause cellular damage to the neural tissue. So there's a combination of things happening here. There's precipitation of this protein called amyloid beta which forms these fibrils and sheets and then these plaques in the brain, insoluble plaques that can't be gotten rid of and you have the immune system attacking and causing inflammation in the brain and then you also have oxidative stress, reactive oxygen species destroying the tissue of the brain. So these factors tend to degenerate the neural tissue. So now we're going to actually go into some different essential oils and different mechanisms that may be able to help. And I'll give you a list of references at the end just like I did in module four when we talked about anxiety and depression. We had a list of references that you can go click on and go see the research literature. I did the same thing for you for this module where you can click on the references and actually go see the studies.",198,"[-0.02710242010653019, -0.0036191646941006184, 0.0009733735350891948, -0.029402820393443108, -0.024987109005451202, 0.005377517081797123, -0.018429646268486977, -0.0036059441044926643, -0.018694059923291206, -0.012665423564612865, 0.0037745079025626183, 0.006497970782220364, 0.012486944906413555, 0.03627758100628853, -0.013062044978141785, -0.0048420787788927555, 0.041512977331876755, 0.025648145005106926, -0.01747775636613369, 0.0024987109936773777, -0.02239585481584072, 0.007172225974500179, 0.011944896541535854, -0.003024233505129814, 0.0128835653886199, 0.016525866463780403, 0.012665423564612865, -0.039476990699768066, -0.02533084712922573, -0.004217401146888733, 0.01203744113445282, 0.005946006625890732, -0.016182128340005875, -0.00502055836841464, 0.008527346886694431, -0.01891881227493286, 0.006821877788752317, 0.0025796876288950443, -0.008474464528262615, 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6,Essential Oils and The Brain Module 5,675.48,776.0,And this specific bacteria or bacterial infection in the mouth can then travel somehow to the brain and cause the same types of problems as Alzheimer's. So they think there's a pretty strong correlation between this bacterial problem in the mouth and the degeneration of the brain. And there's some folks saying that this amyloid beta peptide theory is completely wrong. It's not the reason why people get these plaques. They think this is just a byproduct. The plaques are just a byproduct in the brain. It's really not the cause. And they think the cause is this bacteria that forms in the mouth from gingivitis. So that's an ongoing debate and I won't weigh in one way or the other because I don't know. I mean I don't know if it's this amyloid beta peptide problem or if it's the bacteria. Maybe it's a combination of both. We just don't know yet. But it's very interesting research.,194,"[0.001541531179100275, -0.015421749092638493, 0.04943198338150978, -0.01902616396546364, -0.03485984727740288, 0.024304058402776718, -0.003245583036914468, -0.0019373733084648848, -0.03004537709057331, -0.002466771751642227, -0.0010370740201324224, 0.009120458737015724, -0.009146204218268394, 0.012119846418499947, 0.005921539384871721, -0.01324622705578804, 0.03928812965750694, 0.017906220629811287, 0.0025279182009398937, 0.012197084724903107, -0.020570913329720497, 0.0065973675809800625, 0.025913171470165253, -0.006381746381521225, 0.015692079439759254, 0.009905706159770489, 0.014160203747451305, -0.0355292372405529, -0.027728252112865448, 0.00742123369127512, 0.02557847648859024, 0.009860650636255741, -0.022540468722581863, 0.011501947417855263, 0.015486113727092743, -0.0037009622901678085, 0.012654072605073452, 0.004898143000900745, -0.00037391786463558674, -0.0017668071668595076, -0.01197824440896511, 0.012003990821540356, 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7,Essential Oils and The Brain Module 5,784.28,888.08,"So and then they can't necessarily control the composition of the essential oil because it varies from species to species and source to source. So it's hard to control for the composition of the essential oil in a clinical trial. And the FDA likes to see clinical trials where the chemical composition is exactly controlled and it's the same. And that's why monomolecular therapy is much easier to get through through the FDA because it's one molecule, a drug that's purified and it's one species. And so the FDA knows exactly what it is. Now if you have an essential oil, well you know that all the components of that essential oil, the constituents can change over time. They can be different from species or chemotypal plant, the type of soil, how much air, water, rain it got, you know, how was it harvested, when was it harvested, how was it distilled. All those parameters can change the compositional profile and FDA doesn't like that.",197,"[0.017609063535928726, 0.018316145986318588, -0.016779601573944092, -0.05700169503688812, -0.018207363784313202, 0.03451104462146759, -0.011000566184520721, 0.007193200755864382, -0.04133710637688637, 0.004290084820240736, 0.0019393765833228827, 0.016140509396791458, 0.0003775495570152998, 0.013203398324549198, -0.020818129181861877, 0.03388554975390434, 0.049876485019922256, -0.005350708030164242, 0.000602974439971149, 0.007499149534851313, -0.0093688378110528, 0.028011329472064972, -0.033559203147888184, -0.0028028327506035566, -0.0308124627918005, 0.029697448015213013, 0.031084416434168816, -0.030785266309976578, -0.03951501101255417, -0.005041359458118677, 0.0053439089097082615, 0.007240792736411095, -0.01925439015030861, -0.011959206312894821, -0.004514447413384914, -0.004884985275566578, 0.014345607720315456, -0.019852690398693085, 0.020736541599035263, -0.03649631515145302, 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8,Essential Oils and The Brain Module 5,895.2,969.76,"The antidepressant-like effects of inhaled coriander, volatile oil were studied by means of in vivo, elevated plus maze, and four swimming test approaches. This is in the rat. Also the antioxidant activity in the hippocampus was assessed using catalase-specific activity in the total content of the reduced glutathione. We'll talk about what that means. This is basically looking at oxidative stress. Remember, oxidation is a component of Alzheimer's. We're looking at oxidation in the brain. The beta amyloid, that's that protein that precipitates out and forms the plaques. Retreated rats exhibit the following. Decrease of locomotor activity. The percentage of the time spent and the number of entries in the open arm within elevated plus maze tests. So they're in the maze. They're basically spending their time just kind of meandering around. They're not actually trying to go through the maze. 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9,Essential Oils and The Brain Module 5,977.72,1087.4,"and antidepressant-like effects. Moreover, coriander volatile oil decreased catalase activity, increased glulathione level in the hippocampus. That's the oxidative marker. So basically improving oxidation in the brain. Our results suggest that multiple exposures to coriander volatile oil can be used as a mean to counteract anxiety, depression, and oxidative stress in Alzheimer's disease conditions. So here are some of the results. So here's the result of the locomotor activity in the maze. You can see here's the control mice that don't have Alzheimer's. This is the mice with Alzheimer's plus a drug, which is basically Diazepam, which is an Alzheimer's drug. And then here is the mice with the Alzheimer's that are not being treated with anything. So you can see here these mice have the lowest amount of locomotor activity. 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10,Essential Oils and The Brain Module 5,1093.76,1188.68,"And you can see that the inhalation of the coriander reduced catalase at 1 and 3% and increased glutathione. So these are improved oxidative markers inside the brain. Now this one I thought was quite striking. This is the amyloid plaques. They're stained tissue to show the amyloid beta precipitates, the plaques. And you can see them as these yellow things. So this is the hippocampus of the rat brain and this is the control mouse without Alzheimer's. You can see there is no amyloid plaques precipitating out. These are the mice that have the Alzheimer's. They're the Alzheimer's model of mice, the alpha beta 142. That's basically mice that have Alzheimer's disease. And then here is the same Alzheimer's disease mice that have been treated with 1% coriander and then 3% coriander inhalation.",184,"[-0.013204183429479599, 0.011312078684568405, 0.01998872682452202, -0.02213761769235134, -0.010548479855060577, 0.014731381088495255, -0.015177377499639988, -0.01662348583340645, -0.0384637713432312, -0.013738026842474937, 0.01596124842762947, 0.016880270093679428, -0.0010626191506162286, 0.024935228750109673, -0.00644666887819767, 0.019975213333964348, 0.04146410897374153, 0.001626026933081448, -0.008318500593304634, 0.010582267306745052, -0.018272319808602333, 0.01973194256424904, 0.008609073236584663, -0.0003674398467410356, 0.011555349454283714, 0.01471786666661501, 0.0194346122443676, -0.031165655702352524, -0.00401058467105031, -0.007345417980104685, 0.009291582740843296, 0.010514692403376102, -0.01579906791448593, -0.015474707819521427, 0.001136107137426734, 0.0010516381589695811, 0.006227049510926008, 0.00477756280452013, 0.007183237932622433, 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11,Essential Oils and The Brain Module 5,1190.68,1293.44,"They looked at basal. Here's the study here if you want to go look it up. It's also at the end in the links with the big spreadsheet that I give you with all the links. These studies are in there as well. So the present study analyzed the possible anxiolytic and antidepressant properties of inhaled basal essential oils from these two species. Ok basically basal, different species of basal. I think this one here is called holy basal and then this one is just normal basal. In beta amyloid rat model of Alzheimer's disease, same type of mice that get Alzheimer's disease. The anxiolytic and antidepressant like effects of inhaled basal essential oils were studied by means of in vivo, the same test it did before. The beta amyloid treated rats exhibited the following decrease of exploratory activity, number of crossings. 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12,Essential Oils and The Brain Module 5,1301.4,1411.96,"Our results suggest that multiple exposures to basal essential oils can be useful as a means to counteract anxiety and depression in Alzheimer's disease conditions. Now that's a big component with Alzheimer's, patients get more depressed and they have a lot of anxiety. So if you go back to my module four, where we look at the anxiolytic effects of essential oils, that can be a big help with Alzheimer's patients because they're dealing with anxiety and stress, and if you can improve that, you can improve their quality of life. So that's important to look at. So acetylcholinesterase inhibitors, let's talk about acetylcholine. This is a big target of Alzheimer's drugs that are being studied and put on the market. So here's how it works. Here's a neuron, okay, this is a zoomed in area of a neuron. 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13,Essential Oils and The Brain Module 5,1422.3,1538.6,"So that's increasing neural activity in the brain, and then of course neuromuscular junctions of course too, this works across synapses that go from the nerves to our muscles that cause muscles to contract and things like that, not just in the central nervous system. This acetylcholine, this neurotransmitter, basically builds up. As it's being released, it's just floating around in this synaptic cleft. As more is released, it just kind of builds up. So the body has a way to get rid of the acetylcholine so it doesn't build up to such large concentration that causes problems. So there's a balancing act there. So there's an enzyme, which you see here is this light blue half a circle. They call it acetylcholine esterase. 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14,Essential Oils and The Brain Module 5,1544.84,1691.44,"break down acetylcholine and acetylcholine levels will build up because you don't have this enzyme removing acetylcholine. So the concentration of acetylcholine will increase in the synaptic gap here and now that will increase neural activity. So they use this as a treatment in Alzheimer's patients to try to get their acetylcholine levels back up by making them take drugs that are blockers of acetylcholine esterase inhibitors. So acetylcholine esterase inhibitors, tacrin, domino-pazil, rivastigamine, and galantamine are examples of molecules that can block acetylcholine and acetylcholine esterase inhibitors. So that raises acetylcholine and that gets the neural communication going back. So sorry, essential oils have been shown to be notoriously good at blocking acetylcholine esterase, acetylcholine and esterase. 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15,Essential Oils and The Brain Module 5,1702.16,1806.12,"Here you can see they looked in the actual brain tissue of the mice and three different areas of the rat brain. They looked at the striatum, the hippocampus, and the cortex. And you can see here's the control. These two are the control. And then here is blocking it with the oil, Spanish sage oil. You can see it blocks the activity here of acetylcholine and esterase. In the striatum, a little bit in the hippocampus, not so much in the cortex. Okay, so it depends on the part of the brain. Now one thing I didn't point out here is there's actually two enzymes. There's acetylcholinesterase and there's butyrocholinesterase. Butyrocholinesterase can also break down acetylcholine. Two different enzymes expressed differently in the body, but they both have the capability to break down acetylcholine.",188,"[-0.023666979745030403, 0.007357575464993715, 0.034499891102313995, -0.03748828172683716, -0.03207182511687279, 0.008878452703356743, 0.01374125573784113, -0.014394965954124928, -0.018117113038897514, -0.010706172324717045, -0.00930536538362503, 0.009745619259774685, 0.016796350479125977, 0.02378704771399498, 0.0025648120790719986, 0.025468017905950546, 0.0397028923034668, 0.013914689421653748, 0.0019277781248092651, -0.0033135770354419947, -0.024240642786026, 0.03201846033334732, 0.016689622774720192, -0.02809619903564453, 0.0033552679233253, 0.012687315233051777, 0.019904809072613716, -0.02015828900039196, -0.020958751440048218, -0.009218648076057434, 0.003188505070284009, 0.0022112750448286533, -0.008091331459581852, -0.019091006368398666, -0.025988318026065826, -0.008718360215425491, 0.023827070370316505, -0.024120572954416275, -0.00403899559751153, 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16,Essential Oils and The Brain Module 5,1815.4,1927.6,"fertilizer. Mentha, organic, Lavendula was lavender, organic versus chemical, basil. They had two different varieties of basil. Salvia here, organic versus chemical. So what they showed was all of these essential oils basically have the ability to one extent or another to block acetylcholinesterase. Some of them were better than others. For example, Melissa had no activity on acetylcholinesterase at all. But it had okay activity on butylcholinesterase. This here, the salvia, scleria, had no activity on acetylcholinesterase but good activity on butyrocholinesterase. This is a drug, galantamine. Remember I showed you the different drugs they're developing, acetylcholinesterase inhibitors. This is this drug that they compare these against. So you can get that paper. 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17,Essential Oils and The Brain Module 5,1934.6,2048.64,"So these different constituents, they tested them and you can see that none of the constituents really had the ability by themselves to block acetylcholinesterase like the full oil did. You can see these percentages are much lower. There's a lot more of them that have no ability whatsoever. More of them had the ability to inhibit butyrocholinesterase but still it was not at the same level as the full oil. So there's obviously some kind of synergy that's occurring between all of the constituents working together, blended together inside the oil. And that individual constituents have very little or no activity in certain cases to block these enzymes. So it's definitely synergistic in how it's functioning. So these essential oils have some ability to block the acetylcholinesterase butyrocholinesterase enzymes. Remember, essential oils are great at going across the blood-brain barrier.",181,"[-0.01197142619639635, 0.0003225275140721351, 0.0008683592895977199, -0.03948051854968071, -0.03049200400710106, 0.02601100504398346, 0.013436367735266685, -0.019567912444472313, -0.03929491341114044, -0.008623934350907803, 0.003980532288551331, 0.02578563056886196, -0.01535206101834774, 0.0006935273995622993, -0.021861441433429718, 0.025520483031868935, 0.050881873816251755, 0.008199697360396385, 0.0052863857708871365, 0.002837082138285041, 0.003781671402975917, 0.009817100130021572, -0.009598352946341038, -0.0018941500457003713, 0.007636258378624916, 0.03012079745531082, 0.018255431205034256, -0.03908279538154602, -0.022802716121077538, 0.0029282267205417156, 0.02000540681183338, 0.022511053830385208, -0.010214821435511112, -0.011354957707226276, -0.01777816377580166, -0.01675734482705593, 0.0005820824299007654, -0.02102622576057911, 0.006960131693631411, 0.007019789889454842, 0.00814666785299778, 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18,Essential Oils and The Brain Module 5,2054.0,2160.3,"This is linked for you in the spreadsheet at the end as well. This was basically on people and I thought this was pretty interesting. Recently, the importance of non-pharmacological therapies for dementia has come to the fore. In the present study, we examined the curative effects of aromatherapy in dementia in 28 elderly people, 17 of whom had Alzheimer's disease. After a controlled period of 28 days, aromatherapy was performed over the following 28 days with a washout period of another 28 days. Aromatherapy consisted of the use of rosemary and lemon in the morning and lavender and orange in the evening. To determine the effects of aromatherapy, patients were evaluated using the Japanese version of the Gottfried's brain Steen scale, the functional assessment staging of Alzheimer's disease, FAST, a revised version of Hasegawa's dementia scale, and touch panel type dementia assessment scale. 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19,Essential Oils and The Brain Module 5,2168.4,2262.68,"effects. Conclusion. In conclusion, we found aromatherapy and efficacious non-pharmacological therapy for dementia. Aromatherapy may have some potential for improving cognitive function, especially in Alzheimer's disease patients. Okay, and there's the paper that was published in 2009. Memory. So this is a big thing. Rosemary is known to have great, has a great reputation for improving short and long term memory. Now I link seven papers in the reference section. You can go look up the studies that were done on rosemary. I'll show you one here. Rosemary has traditional reputations that justify investigation for a potential role in reducing widespread cognitive decline in elderly. A randomized placebo-controlled double-blinded repeated measure crossover study was conducted to investigate possible acute effects of dried rosemary leaf powder on cognitive performance. Twenty-eight older adults, 75 years of age and mean, were tested using the cognitive drug research computerized assessment system. 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20,Essential Oils and The Brain Module 5,2271.32,2380.88,"Whereas the highest dose, 6,000, that's pretty high, had a significant impairing effect. So the result, it actually went in the opposite direction when they had too high a dose. There were significant deleterious effects on other measures of cognitive performance, although these were less consistent. Speed of memory is a potentially useful predictor of cognitive function during aging. The positive effect of the dose nearest normal to culinary consumption points, meaning how much you would normally eat rosemary in a diet, to the value of further work on effects of low doses over the long term, points to the value of. So basically they're saying the higher doses of rosemary have the opposite effect that basically less is better. And this is something that I teach in my other courses that I do in the essential oils, that many times we find that less is better and that if you use too much, it can reverse the effects.",187,"[-0.021633051335811615, -5.580749348155223e-05, 0.019747361540794373, -0.03184720501303673, -0.019000941887497902, 0.02368897572159767, 0.0009338419768027961, -0.01321292296051979, -0.025535380467772484, -0.023361599072813988, -0.004521071910858154, 0.02454015612602234, -0.005450821947306395, -0.006662115454673767, -0.01484980620443821, 0.018123572692275047, 0.048058897256851196, 0.0011441814713180065, 0.01774381659924984, 0.0006428859778679907, -0.006138312630355358, 0.024880627170205116, -0.0233354102820158, 0.0119623439386487, -0.0005364885437302291, 0.010259984992444515, 0.020218783989548683, -0.02700202912092209, -0.001185103552415967, -0.021934237331151962, 0.024762772023677826, 0.005365703720599413, -0.005673437844961882, -0.02364969067275524, -0.017206918448209763, 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21,Essential Oils and The Brain Module 5,2392.68,2495.84,"So it's not really high, but it's not really low either. So this is why I think when people apply essential oils to the feet, they get great results. Not because the feet is a faster route into the bloodstream, because on the bottom of the feet you have the largest thickness of padding on the bottom of the feet in terms of adipose or fat tissues. You have that padding there and the essential oils are lipophilic. They love fat. So they're basically going to go into the padding of the foot and they're going to reside there and be released into the bloodstream slowly over time. So it's like a time release system where very small quantities are being released over a longer period of time, as opposed to taking a large dose all at one time. Like ingesting a pill or slathering your entire body with an essential oil and then you get this rapid spike and then it goes away.",186,"[2.3308002710109577e-05, 0.007997834123671055, -0.0015265574911609292, -0.035867463797330856, -0.005021046847105026, 0.0037732517812401056, -0.028699280694127083, -0.04056660458445549, -0.025221385061740875, -0.01105094887316227, 0.02151782251894474, 0.02418597973883152, -0.014641677029430866, 0.006856234278529882, -0.03374355658888817, -0.008143852464854717, 0.046725932508707047, 0.014787696301937103, 0.011953609064221382, 0.009252266027033329, -0.015292123891413212, 0.012146087363362312, -0.007340750191360712, 0.0082699591293931, -0.00665711797773838, 0.011880599893629551, 0.019672680646181107, -0.017601871863007545, -0.0345931202173233, -0.02053551748394966, -0.0019330864306539297, 0.011873962357640266, -0.015557612292468548, 0.009955809451639652, -0.01638062484562397, 0.008415977470576763, -0.009969084523618221, -0.028141755610704422, 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22,Essential Oils and The Brain Module 5,2501.96,2612.08,"term memory. So those are in the reference section if you want to go look at them. So I think memory is definitely an issue with Alzheimer's. So this could help. So now the other factor is obviously oxidation. Remember I said one of the factors contributing to the degeneration of neural tissue in the brain is this oxidative stress, reactive oxygen species being higher because the mitochondria in the cells are dysfunctioning and then you also have the immune system attacking and the immune system naturally generates reactive oxygen species when it's in a state of inflammation and attacking the tissue. So here are some studies that show lavender has this amazing ability to be a norprotective to protect against oxidative damage in neural tissue in the brain. So here's a study. Lavender is reported to be effective medicinal plant treating inflammation, depression, stress and headache.",168,"[-0.00749944057315588, -0.0006925604538992047, 0.023955995216965675, -0.038123805075883865, -0.009669463150203228, 0.021581502631306648, -0.01495930552482605, -0.0249981340020895, -0.025618141517043114, -0.016489535570144653, -0.0074334824457764626, 0.02904796414077282, -0.0009497972205281258, 0.010124574415385723, -0.02712198719382286, 0.005194203462451696, 0.03904721885919571, 0.004617069847881794, 0.01791423000395298, 0.0076643358916044235, -0.023058965802192688, 0.00776327308267355, -0.0014700420433655381, 0.005923040676862001, 0.006463897414505482, 0.02344152331352234, 0.004890795797109604, -0.036646343767642975, -0.01973467506468296, -0.009326481260359287, 0.007914976216852665, 0.007031137589365244, -0.007783060427755117, -0.03113224171102047, -0.008798815310001373, -0.016120169311761856, 0.00594612630084157, -0.012690345756709576, 0.009735421277582645, 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23,Essential Oils and The Brain Module 5,2625.68,2715.52,"So that's why it says lipid peroxidation there. And DNA fragmentation assay. So when DNA in the cell gets cut up or fragmented, it's an indicator that the cells are going through a state of apoptosis, meaning that they're committing suicide. So when a cell commits suicide, it's committing apoptosis. It's executing a program to destroy itself. And in the process of destroying itself, it's chopping up the DNA into smaller pieces so that everything can be recycled. So they look at the DNA fragmentation, they can tell if these cells are committing apoptosis or not, committing suicide. So in scopalamine, treated rats. So this is basically scopalamine. They give the rats scopalamine. It basically induces dementia in these rats. So that's how they get the rats to have dementia. 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24,Essential Oils and The Brain Module 5,2722.68,2835.0,"Also DNA cleavage patterns, the fragmentation of DNA, were absent in the lavender group suggesting anti-apoptotic activity, meaning that the cells were not committing suicide, the DNA was not fragmented. Taken together our results suggest that antioxidant and anti-apoptotic activities of the lavender essential oils are a major mechanism for their potent neuroprotective effects against scopalamine induced oxidative stress in the rat brain. So these rats were being basically driven towards dementia through oxidative stress in the brain, they did that through this molecule, it's scopalamine, they gave them lavender and the lavender basically reduced all the oxidative stress and it stopped the cells from committing suicide. 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25,Essential Oils and The Brain Module 5,2848.2,2965.68,"which is the control was given to the rats. The infarct size, the cerebral edema, the amount of swelling, the functional outcome and the oxidative stress biomarkers were evaluated using standard methods. We'll read through this. Treatment with lavender oil at doses of 200 or 400 milligrams significantly diminished infarct size, brain edema and improved functional outcome after cerebral ischemia. Lavender oil at 200 milligrams also reduced the content of malondyldehyde, that's the MDA, that's the lipid peroxidation, measure of oxidation in the brain and increased the activities of superoxide dismutase, glutathione peroxidase and total antioxidant capacity. 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26,Essential Oils and The Brain Module 5,2981.88,3109.36,"that can help reduce oxidation in the brain can be something that's significant in terms of helping to stave off the progression of the disease. That's basically the conclusion of that. So here's the references, you can go through these and there's a link on each of these and you can click on it and a lot of times you get the paper, sometimes you just get the abstract. If you get, some of them want you to pay, read the whole paper, you can at least read the abstract. If you want to read the whole paper just email me, say I want to look at this paper, I can get it for you for free, don't worry about paying for it. So here's the coriander study, this is the basil study we showed at the beginning. These are papers on acetylcholinesterase inhibitors and essential oils. There's a number of those. 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27,Essential Oils and The Brain Module 5,3117.2,3215.6,"You can get the DVD of this whole series for your permanent records. I have the link at the top of the video. It's $15 for the DVD set, so order it now so I know how many to make so I can get it manufactured, produced, and then send it to you for your permanent records. So thank you so much. This series has been great. I really enjoyed being with all of you, enjoyed interacting with you. Hope this information was useful to you and your family. I know everyone has different issues they're dealing with with family and family members. Hopefully this gave you a good footing to be able to discuss things with them, to show them certain things, to help them, and use this information in your own life, in your own family, in your own health. So there's lots of good things that are going to be happening. I'm coming out with a new book called How Essential Oils Work.",192,"[-0.01160383690148592, 0.0002744989178609103, -0.0016722300788387656, -0.05645038187503815, -0.005662910640239716, 0.01258351095020771, 0.0006313268677331507, -0.030184539034962654, -0.028198713436722755, 0.0008067413582466543, -0.001946108415722847, 0.017514975741505623, 0.00014324831136036664, 0.028993044048547745, -0.006086553446948528, 0.014496522024273872, 0.03484460711479187, -0.009710683487355709, 0.011729605495929718, -0.0007120009977370501, -0.021566059440374374, 3.707907671923749e-05, -0.001184875494800508, 0.004262904170900583, 0.009809975512325764, 0.017925379797816277, 0.0068378569558262825, -0.025908395648002625, -0.009618012234568596, -0.006596248596906662, 0.005891280714422464, 0.00984969176352024, 0.0068113794550299644, -0.029231343418359756, -0.008942831307649612, -0.009240705519914627, -0.016985422000288963, 0.004236426670104265, 0.014642149209976196, -0.017488498240709305, 0.006791521329432726, 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28,Essential Oils and The Brain Module 5'Essential Oils and the Brain Module 4,0.0,3296.34,"So you can give them out to people that may be thinking about essential oils and just don't know or skeptical. And they just want a quick read and you want to hand it to them and say, here, check this out. That's something they might be able to read. And also give you a better understanding of how they work so you can communicate with others how essential oils actually work inside the body and what they actually do. So that'll be coming out in say a month, that book. So I'm going to be putting a link up pretty soon for people to pre-order if they like the book. And then I'm starting another group, a new group for essential oil education that will be more generic, but it'll be an ongoing type of thing where every month I'm putting in information that you can use just sort of like on a yearly basis. So that new group is going to be coming out soon as well. 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29,Essential Oils and the Brain Module 4,109.0,260.0,"Good evening everybody, this is Doug bringing you Module 4 of the Essential Whales in the Brain series that I've been working on the last couple of months. Thank you for being patient with me as I bring this series to you and deliver this information. I hope it's been useful to you. Sorry for the delay and getting started, I had a little technical glitch tonight so hopefully everyone is still jumping on. This is Module 4, so tonight it's not going to be that long, it should be done in less than 30 minutes. There's a lot of information in this module and I'll show you what I mean by that. But there's homework for you to do after this module is done. So lots of great information for you. We're going to talk about anxiety and stress tonight and essential oils that help with anxiety and stress. Next week we're going to touch on memory, dementia, neurodegenerative disorders like Alzheimer's and things like that.",199,"[-0.017830491065979004, 0.011200523935258389, 0.0018401809502393007, -0.04270282760262489, -0.03252536430954933, 0.009925019927322865, -0.01667456328868866, -0.022387761622667313, -0.012535817921161652, -0.007407226599752903, -0.011526043526828289, 0.023915709927678108, -0.009931663051247597, 0.013685100711882114, -0.0014905798016116023, -0.011824989691376686, 0.033056825399398804, 0.002433091402053833, 0.01174527034163475, -0.008888672105967999, -0.009739008732140064, 0.0018883445300161839, 0.009087969549000263, -0.0017056551296263933, 0.029947783797979355, 0.01704658567905426, 0.013479159213602543, -0.00853658001869917, -0.015239621512591839, -0.031090421602129936, 0.008769093081355095, 0.020554224029183388, -0.001581094111315906, -0.01512004341930151, -0.011798416264355183, -0.02909744717180729, 0.012941055931150913, -0.008118054829537868, 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30,Essential Oils and the Brain Module 4,269.0,406.0,"And then that will pretty much finish up the entire series so there's going to be five complete modules. And if you haven't already, you can jump on my series that I'm working through now. We're already through Module 2, going to Module 3. For the Science of CBD, there's instructions in the feed on how to sign up for that. You can't go to Starfish Sense to sign up for this class because Etsy does not allow the word CBD to appear on their website anywhere. So that's just part of their policy and I can't get past it. So there's special instructions to sign up for the CBD course in the feed if you'd like to do that. And you get the videos, you get the slides just like you do for this class. It's the same setup. You go into a special Facebook group. You get all the videos that are given as well as all of the slides. So we're going to talk about anxiety tonight.",201,"[-0.006885793525725603, 0.001844653394073248, 0.0022502033971250057, -0.02809075079858303, -0.03608538955450058, -0.0016187775181606412, -0.0426015704870224, -0.029103770852088928, -0.006345060188323259, -0.0006904616602696478, -0.01108845416456461, 0.008179446682333946, -0.021314473822712898, 0.015688110142946243, 0.012149387039244175, 0.006091805174946785, 0.03693413734436035, 0.0010643547866493464, -0.0034155177418142557, -0.007645558100193739, -0.00545866833999753, 0.01520897913724184, 0.01441499125212431, -0.0163041353225708, 0.0019165229750797153, 0.0049761151894927025, 0.005379953887313604, -0.010492963716387749, -0.03696151450276375, -0.010602478869259357, 0.011458070017397404, 0.010889957658946514, -0.005691389087587595, -0.024928487837314606, -0.004257419146597385, -0.014989947900176048, 0.001954169012606144, 0.010629857890307903, 0.016687439754605293, -0.019014645367860794, 0.02935018017888069, -0.0008123833104036748, 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31,Essential Oils and the Brain Module 4,420.0,580.0,"They can manifest in a lot of different ways. Obsessive-compulsive disorder, post-traumatic stress disorder, social anxiety disorder, certain kind of phobias that people can have, just general anxiety disorder. I'd say we're probably all walking around with some type of general anxiety just as a normal state of being, as being human, and especially in the United States. There's just a lot of anxiety that comes along with living in a Western fast-paced society. But then there's also chemical imbalances, genetic disorders that can lead to really serious problems with anxiety. Doctors tend to prescribe different types of medications to deal with anxiety. People have really serious anxiety disorders. I think that it's over-prescribed. A lot of these psychological things are pretty much over-prescribed by doctors. That's not to say that people don't have real problems. But it is a chronic problem in the United States where doctors just give away anxiety meds or antidepressants like candy.",197,"[-0.00047177664237096906, 0.028484627604484558, 0.035139672458171844, -0.02843283675611019, -0.0214541032910347, 0.012928136624395847, -0.032368894666433334, -0.016326870769262314, 0.005324683152139187, 0.007917432114481926, -0.014294104650616646, 0.0003087183285970241, 0.0027804882265627384, 0.027811354026198387, -0.004596383310854435, 0.023020759224891663, 0.04609330743551254, 0.005593345034867525, -0.008817287161946297, -0.024522675201296806, -0.0067650992423295975, 0.018307847902178764, -0.015524121932685375, -0.010364520363509655, -0.01689656265079975, 0.021894320845603943, 0.018553851172327995, -0.015187486074864864, -0.003978137392550707, -0.01655992679297924, 0.0007303231977857649, -0.02794083021581173, -0.02066430263221264, -0.017272042110562325, -0.012824556790292263, -0.017518045380711555, -0.009607087820768356, 0.0007080695941112936, 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32,Essential Oils and the Brain Module 4,584.0,708.0,"They fall into different classes of different types of medications, and they have different mechanisms of action. A doctor may try several different types with a particular patient as the patient responds to it, and then may have certain types of side effects that go along with that. They might have to adjust dosage or completely switch. They might put you on a mix of different types of drugs to get it right. It's really tricky for doctors to get this right, and it can cause a lot of problems, a lot of side effects. Serotonin reuptake inhibitors are one class called SSRIs. Tri-cyclics, the monoamine oxidase inhibitors are another. The benzodiazepines are another class of medications or anti-anxiety drugs. You recognize some of these names here. 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33,Essential Oils and the Brain Module 4,727.0,885.0,"Sexual dysfunction, clinical effect delay, what that means is it can take several weeks for some of these drugs to actually start working. You might not know if it's working for two weeks up to a month. Sedation, where you just basically can't function because you're sleepy all the time. Dizziness, and then of course suicide or big side effects or drawbacks to these medications. But there's a lot of folks on these types of drugs. Now, essential oils have been studied quite extensively for their ability to affect anxiety. They're called anxiolytic. If you want to know the real term, it's anxiolytic. If you're doing a search in PubMed or for clinical trials, you can type in anxiolytic and essential oil. Now, at the end of this module, I'm going to give you lots of references that you can click on, bring you right to the article, and it'll show you the research that was done.",199,"[-0.01596093736588955, 0.004689519759267569, 0.02472354657948017, -0.03961069881916046, -0.03627003729343414, 0.01619955711066723, -0.026937397196888924, -0.02246992476284504, -0.007397179026156664, -0.0173793938010931, -0.004878425970673561, 0.03862971067428589, -0.019314855337142944, 0.033486153930425644, -0.013601263985037804, 0.012885408475995064, 0.052416566759347916, 0.01409175805747509, 0.0002941306447610259, -0.01197070349007845, -0.013667547143995762, 0.010214204899966717, -0.019354624673724174, 0.006250483449548483, -0.013998962007462978, 0.007132046855986118, 0.0016098475316539407, -0.012361773289740086, -0.03178931027650833, -0.002739143557846546, -0.016690051183104515, 0.02366301789879799, -0.021581733599305153, -0.014675048179924488, -0.011765225790441036, -0.03194838762283325, 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34,Essential Oils and the Brain Module 4,900.0,1060.0,"So these are doing a review of the literature out there. These are the species of plants or essential oils that have been studied for their anxiolytic effects activity. And it could have been done in humans or mice. Some studies have been done in humans and some have been, a lot of them have been done in mice. But it's not surprising that you find that a lot of different essential oils have these types of effects when they're basically the terpenes and the terpenoids which make up essential oils are common among a lot of essential oils. So it's not surprising that you're going to see this type of effect or bioactivity in essential oils occurring across a variety of different species. So we're going to go over some of these and not all of them, of course, in one module. We're going to go over several of these and then I'll give you a list of references that you can go look these up for yourself.",195,"[-0.01181709859520197, 0.004582073539495468, 0.0019864386413246393, -0.04815926402807236, -0.006298304069787264, 0.01667756959795952, -0.02960825338959694, -0.008044011890888214, -0.0074610174633562565, -0.008895576931536198, -0.021105704829096794, 0.009681636467576027, -0.026634326204657555, 0.01887853629887104, -0.02295294590294361, 0.02934623323380947, 0.045958295464515686, 0.015380569733679295, -0.0012118421727791429, 0.006042834836989641, -0.02584826573729515, 0.021105704829096794, -0.022573016583919525, -0.013808450661599636, -0.0015762136317789555, 0.010618357919156551, 0.02625439688563347, -0.03980082646012306, -0.03120657429099083, -0.008482895791530609, -0.006393286399543285, 0.012825875543057919, -0.0265688207000494, -0.016179731115698814, -0.009098642505705357, -0.028874596580863, 0.01756843738257885, 0.0014361967332661152, 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35,Essential Oils and the Brain Module 4,1075.0,1224.0,"So what they did is they took 25 patients. They administered to them aromatherapy in the form of massage. They used Jojoba oil that was the carrier oil that was mixed with lavender basically. Two percent was lavender and the other two percent was geranium. So they did massage. They did it for four weeks, two times a week. So for a total of eight different treatments. And then they followed the electroencephalogram, which is the EEG with the brain patterns. Remember in one of the previous modules, we went over alpha waves, beta waves, gamma, delta waves. Those are basically the electrical wave patterns that the brain makes. They follow the EEG pattern on the brain to look at if alpha, beta, gamma or delta wave power intensity increased or decreased. And from that they can tell if there's an effect on the brain. They looked at salivary cortisol, which cortisol is a stress hormone. 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36,Essential Oils and the Brain Module 4,1234.0,1353.0,"It comes through the HPA axis, so the hypothalamus pituitary adrenal axis. So if stress, fight or flight response, you'll have a signal coming from your hypothalamus to your pituitary to your adrenal. And your adrenals will secrete cortisol into your bloodstream, which is a stress hormone. So you can measure stress, which is a marker of anxiety and stress by measuring cortisol. And then another factor we looked at was brain-derived neurotrophic factor, BDNF. And I'll talk about what that is and what that means here in a second. So here's the results of the EEG studies that they did. Now remember they're using lavender and geranium. Now I will say that if you look at anxiety, anxiolytics, lavender is the number one, you know, the highest frequency of papers and research studies have been done around lavender.",183,"[-0.03302806243300438, 0.003467555856332183, 0.02048625610768795, -0.03860219940543175, -0.0029677720740437508, 0.003995015285909176, -0.02486221306025982, -0.022739352658391, -0.006570448633283377, -0.00601043039932847, -5.9115318435942754e-05, 0.029694000259041786, -0.015302829444408417, 0.017790352925658226, -0.014599550515413284, -0.009494265541434288, 0.034486714750528336, 0.01600610837340355, -0.016032155603170395, 0.0004753644752781838, -0.01280228141695261, 0.0047796922735869884, 0.022127239033579826, 0.007605831604450941, -0.0064564915373921394, 0.002839163178578019, -0.003920129034668207, -0.01850665546953678, -0.020329970866441727, -0.00680487509816885, -0.007729556877166033, 0.013922318816184998, -0.030110757797956467, -0.0008571212529204786, -0.00022689699835609645, -0.009038437157869339, 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37,Essential Oils and the Brain Module 4,1358.0,1473.0,"So you have to piece together different research studies and none of them are really comparative. So it's like comparing apples to oranges. It's just because lavender appears more frequently in research literature doesn't mean it's better. It just means that researchers have studied that one more often than not. Could be that, you know, that's a common knowledge factor that people know that lavender helps with anxiety. And so researchers tend to use that one to study. And so just because it appears the most in the literature doesn't mean it's necessarily the best, although it could be, right? So we just don't know which one is the best. So they looked at these factors. So here's the EEG pattern. Okay, so the EEG pattern, remember, is electrical brain activity. Look at alpha waves, beta waves, gamma, delta. And those are just electrical waves that occur in the brain at different frequencies. 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38,Essential Oils and the Brain Module 4,1482.0,1630.0,"So you can see those here. So this was the power of those waves, how intense they were before, which is the black and then after treatment, the white. And you can see that the beta, theta and delta, this is one time, you know, after aromatherapy one time. And then this is this is after four weeks, you know, after the eighth trial, just looking at the alpha wave. So here they're looking at all the waves, alpha, beta, theta, delta after one time. And you can see the alpha power goes up. The rest basically stay the same. Then they concentrated on the alpha waves and looked at what happened after the four week period, the eight treatments with the patients. And they saw a market increase in the alpha waves during the first treatment as well as in the last treatment, the eighth treatment. So the alpha waves are going up in the brain as they're going through this aromatherapy.",195,"[0.007985280826687813, -0.020308244973421097, 0.005839441902935505, -0.02734054997563362, -0.02108377031981945, -0.01367027498781681, -0.008412476629018784, -0.033202994614839554, -0.013985742814838886, -0.01250698696821928, -0.018652038648724556, 0.0284446869045496, -0.0031793247908353806, 0.0069140042178332806, 0.01456410065293312, 0.01306562777608633, 0.03612107038497925, 0.017942234873771667, 0.0060004619881510735, 0.010173838585615158, -0.006841709371656179, 0.025303153321146965, -0.0146955456584692, 0.011981206946074963, -0.018191980198025703, 0.018283993005752563, 0.016470052301883698, -0.017482178285717964, -0.019795609638094902, -0.0011427495628595352, 0.006348791066557169, -0.0014105685986578465, -0.023423489183187485, 0.001354704494588077, -0.008458482101559639, -0.01273044291883707, 0.016640931367874146, 0.0075186509639024734, 0.02018994465470314, 0.004170090891420841, 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39,Essential Oils and the Brain Module 4,1647.0,1830.0,"which is associated with relaxation and focus. They also looked at cortisol, like I said, which is the level of that hormone in the bloodstream after treatment. And there was a decrease in cortisol that was statistically significant after just one time massage. Now, when they looked at this over the four weeks or the eight treatments, they did not see a long term decrease in cortisol levels. They only saw the decrease, you know, as a temporary decrease right after aromatherapy. So you have the aromatherapy recession, it decreases, but then it pops back up and it doesn't go down over time as you're going through the sessions. So it's a short term effect, not a long term effect. And then they looked at BDNF. Now, what is BDNF? It's Plasma Brain Derived Neurotrophic Factor. It's a member of the neurotrophin family. 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40,Essential Oils and the Brain Module 4,1849.0,2003.0,"What it does in the brain is it helps synapses form, which they call synaptic plasticity. So new neurons and new nerve circuitry can form in the brain. This is how you learn. This is how you memorize things. This is how your brain, you know, grows. So that's called plasticity. So that means that the neurons can basically, new neural connections can form. So the BDNF helps promote new neurons from forming, new synapses forming in the brain. So this is good, right? So if you have high levels of BDNF, that means that your brain is learning. It can develop new neural connections and all of that. So it's also a biomarker they're using for depression. 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41,Essential Oils and the Brain Module 4,2014.0,2133.0,"So this higher level of BDNF is also a very positive thing with this aromatherapy. Then they looked at different psychological tests that they do on the patients to try to assess what their level of stress, anxiety, and depression is. So they used three different tests. They used the State Trade Anxiety Inventory, the STAI, which was a degree of measures of anxiety in the patients. The Back Depression Inventory, the BDI, is used to look at depression. And then the Psychosocial Well-being Index, PSI, is measures stress, so you have anxiety, depression, and stress. Three different tests. So here, anxiety, depression, stress. This is the control group, the placebo, and you can see before the treatment and four weeks after, this is the change, okay? And that study, and that level of that test. So you can see pretty much those in the control, there was really no significant change in either anxiety, depression, or stress tests.",201,"[-0.02476433664560318, 0.007511804345995188, 0.04218320548534393, -0.04114525765180588, -0.039229050278663635, 0.017671702429652214, -0.034358687698841095, -0.014132039621472359, -0.015369590371847153, -0.025416379794478416, -0.03206988051533699, 0.01893586851656437, 0.00908203050494194, 0.027864867821335793, 0.008010816760361195, 0.005625536199659109, 0.03930889070034027, 0.01857657916843891, 0.006696750409901142, -0.020253261551260948, -0.021956557407975197, 0.023340485990047455, -0.021424278616905212, 0.012581773102283478, -0.015569196082651615, 0.012921101413667202, 0.010998239740729332, -0.028024552389979362, 0.006257619243115187, -0.007338813040405512, 0.0033616821747273207, 0.000964757869951427, -0.023114267736673355, -0.027439044788479805, -0.009946986101567745, -0.025682520121335983, -0.008736048825085163, -0.0005181414890103042, 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42,Essential Oils and the Brain Module 4,2140.0,2223.0,"But the folks that went under gone therapy, their levels decreased for stress, anxiety, you can see from 10.8 to 6.5, and the stress index here. So you can see that went down. So they all three went down, but in the control they didn't. So this is after four weeks, okay? So this is corroborating what they're finding in these measurements that are objective measurements. These are more subjective because they're based on tests, you know, asking the patient questions. So now what I've done is I've went through, done literature research for you in the research literature, and I looked at a large array of different studies that were done on anxiety and essential oils. And what I've done is I've collected that information into this table, okay? And in this table you have the title of the study, okay, here, the title with the actual reference. 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43,Essential Oils and the Brain Module 4'Essential Oils and the Brain Module 3,0.0,2346.0,"When you go to that PDF file, that blue link, you can click on it, you see how that's coming up right there? That hyperlink, if you click on that, your web browser will actually go to the research study, and you'll be able to see the abstract. Now in some of these you'll be able to just see the abstract, and it wants you to pay $20 or something to actually see the entire study. In some of these the PDF is there because it's free. Now if you go to one and it says that it wants you to pay, what you can do is click, cut and paste the title, you know, just title of the study, put it into Google, paste it into Google, and you might be able to find the PDF somewhere else, okay, because other, like ResearchGate and some of these other places, repositories, will actually publish the PDF that the actual journal did not publish they want you to pay for.",199,"[-0.019336646422743797, 0.0013581998646259308, 0.021435096859931946, -0.03612425550818443, -0.010118911042809486, 0.0009108307422138751, -0.026777779683470726, -0.018113622441887856, -0.006816747132688761, -0.008870139718055725, 0.00545854726806283, 0.03169562295079231, -0.009539583697915077, 0.03185010701417923, 4.7874935262370855e-05, -0.004309548996388912, 0.031154915690422058, -0.0032426216639578342, -0.014689156785607338, -0.0009631310822442174, -0.03638173267245293, 0.011284002102911472, -0.010324893519282341, -0.0010009482502937317, -0.015680449083447456, 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44,Essential Oils and the Brain Module 3,102.28,201.6,"Selexan, S-I-L-E-X-A-N. Selexan was actually, went through a full scale FDA phase one, phase two, phase three, clinical trial like a drug would go through, and it gave it a name called Selexan, but it's basically lavender oil, okay. So lavender oil has been approved by the FDA for anxiety. And it's actually an over the counter now. So if you go to Amazon or CVS and you type in Selexan, it may not come up under that name, but they'll have lavender capsules that you can take. And they can claim on the box that this is for anxiety, okay, because it's went through this clinical trial. So if somebody ever asks you why, you know, essential oils have never been through clinical trials and all that, that's false, okay. There have been clinical trials with essential oils, and there are some of them that can either be prescribed or over the counter.",198,"[0.016757672652602196, 0.02153228037059307, 0.0050938003696501255, -0.029871216043829918, -0.027690060436725616, 0.029419025406241417, -0.04157498851418495, -0.039846021682024, 0.003428008174523711, -0.007115361280739307, 0.001009949017316103, 0.007820247672498226, -0.030855398625135422, 0.011876667849719524, -0.017994549125432968, 0.01625228300690651, 0.0368402823805809, -0.0008108685724437237, -0.0024903763551265, -0.013399488292634487, -0.007866796106100082, 0.001983323832973838, 0.006500248331576586, -0.003790426068007946, -0.031147992238402367, 0.008252489380538464, 0.005961608607321978, -0.0214258823543787, -0.016332080587744713, 0.008944075554609299, -0.0024671019054949284, 0.019962910562753677, -0.01912502758204937, -0.0034479578025639057, -0.011590723879635334, -0.008884226903319359, 0.009449465200304985, -0.012834249064326286, 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45,Essential Oils and the Brain Module 3,210.28,286.02,"I give a good snapshot. There's hundreds and hundreds of articles. I only give you probably 30 or 40 here, but it's a good snapshot, a good cross section. If you really want to do a more exhaustive scan of the literature out there, just type in anxiolytic, A-N-X-I-O-L-I-T-I-C, and essential oil. And you'll see, just go to Google Scholar. Okay, don't go to Google, but go to Google Scholar. First go to Google Scholar and then type in anxiolytic essential oil or anxiety in essential oil. And you'll see all the studies, they'll come up. Okay, so I give you a good cross section here of different essential oils. So lavender, this study here, they used rose, lavender, lime, and a blend of lavender, langlang, bergamot, and patchouli.",185,"[-0.014602825976908207, 0.03335164859890938, 0.018866904079914093, -0.04875480756163597, -0.030596395954489708, 0.008265750482678413, -0.02515149861574173, -0.0324857123196125, 0.005674503277987242, -0.021897679194808006, -0.009840179234743118, 0.021543432027101517, -0.016623342409729958, 0.03476863354444504, -0.005490819923579693, 0.011047241277992725, 0.05140509456396103, 0.011047241277992725, -0.011211244389414787, -0.0006396116223186255, -0.008370712399482727, 0.01596732996404171, -0.005920507945120335, 0.0005272696143947542, -0.0034834234975278378, 0.019194908440113068, 0.019549155607819557, -0.009971381165087223, -0.01248390693217516, -0.0134154437109828, 0.005608902312815189, 0.006638840772211552, -0.030806319788098335, -0.024062518030405045, -0.005720424000173807, -0.007865583524107933, 0.0033522211015224457, -0.005064412020146847, 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46,Essential Oils and the Brain Module 3,295.92,404.0,"So this was massage, and they could choose from one of these different oils in this study. Now a lot of these studies here at the beginning that I showed you are actually studies that were done in hospitals that they were looking at patients that were about to undergo some type of surgery, cardiac surgery or cancer patients, okay, and they're looking at can they use aromatherapy as a way to reduce stress and anxiety while they're in the hospital, okay. And a lot of those types of studies have been done and they all have shown very good results. And so I list a lot of these here in the beginning section of this reference system for you. Some of these are actually studies that were done on nurses that exist in these hospital environments and are stressed out themselves, and they're using aromatherapy to try to help reduce their stress levels by having to deal with patients. 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47,Essential Oils and the Brain Module 3,413.16,521.2,"And then you have other oils as well. So here's bergamot, that's a citrus oil. Lavender, Roman chamomile, and neroli, and they put it in this ratio here. So here's a blend, if you want to try that. It actually shows you the ratio, 6 to 2 to 1.5. This is the study here. Here was lavender and bergamot together as a blend. Here is a blend of four essential oils. They chose essential oils from a list of 20, and then took up to four and blended them together. They had a certified aromatherapist that looked at the patient's symptoms, and they made a blend that was specific to them based on their symptoms. But the median, or the most frequently used essential oils in the blends were lavender, chamomile, geranium, juniper, bergamot, jasmine, and rose were the most frequent that were used in these blends.",199,"[0.010592402890324593, 0.014953229576349258, 0.0025539246853441, -0.049954768270254135, 0.004731145687401295, 0.01646004430949688, -0.005072732921689749, -0.011786362156271935, -0.02837410382926464, -0.02944675274193287, -0.02132527157664299, 0.02473476156592369, -0.019997229799628258, 0.013535801321268082, -0.013114403001964092, 0.03866641968488693, 0.04627711698412895, 0.015872642397880554, 0.019409827888011932, 0.016204651445150375, -0.0019505600212141871, 0.01086056511849165, -0.010317855514585972, 0.0034031046088784933, -0.010439167730510235, 0.022793777287006378, 0.03761931136250496, -0.024275055155158043, -0.018962891772389412, -0.005235545802861452, 0.014123204164206982, 0.01334425713866949, -0.009174974635243416, -0.008491800166666508, -0.007904397323727608, 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48,Essential Oils and the Brain Module 3,532.14,645.72,"Here's lavender, langlang, and bergamot in this study. Bergamot, lavender, lavender in these studies. Lavender. So this was a blend of basil, juniper, lavender, and sweet marjoram. That was this study. Lavender. This was that study I just showed you, the results of the 2% lavender, 2% geranium, and jojoba oil. Lavender. Here is bitter orange. This is lemongrass, lavender, angelica, lemongrass, fennel, bitter orange, sandalwood is used, rose, few studies on rose, lemon, coriander, clove, basil, and that's not the same as clove or the same as basil. It's called clove basil. And that's the species there. Copaiba was also studied. And then here's actual basil here. 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49,Essential Oils and the Brain Module 3,656.2,765.76,"from people that are naysayers is show me the evidence, show me where this is being used. This is a snake oil. There hasn't been any good science around this at all. And that's just not true. You just have to know how to find it, what to look for, what to search for. And again, this is just a snapshot. So you're going to find hundreds of studies like this around anxiety. Now next week in the last module, I'm going to do a similar thing for you with dementia, Alzheimer's, neurodegenerative things that you're looking at, and aging disorders of the brain and how these studies, even some of these studies actually touch on that. If you look through the titles, you'll actually see some of these studies have to deal with that. 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50,Essential Oils and the Brain Module 3,774.2,864.06,"So they were looking at anxiety, but they were also looking at say Alzheimer's, right? So you'll see that in a few of these. But next week on the next module, I'll focus on that. So you'll have those references. Okay? So that, like I said, it's short because there's a lot of work here for you to do. You go click on these links, go look at some of these studies. This gives you some ideas of essential oils and blends you can try. Again, everybody's source of anxiety is probably going to be different. Everyone's brain chemistry is different. There's different pathways, neurological pathways that can be depressed or activated that can cause anxiety from serotoninergic receptors to GABA receptors, acetylcholine. There's different neurotransmitters. There's different neural pathways in the brain. 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51,Essential Oils and the Brain Module 3,866.68,982.6,"They're not having to do this for weeks before they start to see a result. Remember what I said with some of these medications that people are taking for anxiety, they can take up to a month before they actually start seeing results. Okay. And in terms of safety, if you go look at this first reference on Celexan, this is a clinical trial that was done. They looked at adverse reactions, which is something they have to measure for a clinical trial. They look at side effects, adverse reaction. They have to look at adverse reaction levels, percentage. You know, how percentage of the folks that were in the clinical trial, how many reported something negative happening to them, an adverse reaction. And they did it alongside, I think the Azepam was the drug that was used as the control, basically a prescribed drug.",169,"[0.005608572158962488, 0.006307217758148909, 0.027531815692782402, -0.039538171142339706, -0.014878565445542336, 0.02202027663588524, -0.02704017609357834, -0.013571838848292828, -0.0019261273555457592, 0.0027460656128823757, 0.01203223131597042, 0.034958161413669586, 0.0003262772224843502, 0.029420746490359306, 0.0011385336983948946, -0.0003153608995489776, 0.040081560611724854, 0.013998789712786674, -0.016961565241217613, -0.008422561921179295, -0.003800503211095929, -0.015111447311937809, -0.01750495471060276, 0.008441968820989132, -0.020868804305791855, 0.0017805761890485883, 0.005281890742480755, -0.010427933186292648, -0.004457100760191679, -0.012446243315935135, -0.00318595371209085, -0.013455398380756378, -0.017763713374733925, -0.007232276722788811, -0.012439774349331856, -0.016948627308011055, 0.011236551217734814, -0.019665582105517387, 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52,Essential Oils and the Brain Module 3,992.56,1102.48,"So this is a good study to show people if they ask about, is it safe to ingest essential oils? Well, here is a clinical study that they actually looked at adverse reactions. And you can show them that. And there's other studies too. But that's it. I think I'll finish up there. Next week we'll do the same thing for Alzheimer's, neurodegenerative disorders of the brain, aging disorders. And then we'll finish up the entire series. Again, if you want to jump in on the CBD, we have a couple more modules to do there. We've already done two. And it'll probably have four total when it's finished. You get all the slides, you get all the videos, everything like that. But the instructions are in the feed of this group to get that class. Also, if you want this series on DVD, you can get it on DVD.",186,"[-0.004877182655036449, -0.007876983843743801, 0.0154600003734231, -0.04454938694834709, -0.023904874920845032, 0.02467988058924675, -0.00837138295173645, -0.01705009490251541, -0.022408315911889076, 0.014618185348808765, 0.004048729781061411, 0.016863025724887848, 0.006737861316651106, 0.02415875717997551, -0.0017086841398850083, 0.003941832575947046, 0.051631323993206024, 0.001636027474887669, 0.0037480813916772604, -0.005227938760071993, -0.018546655774116516, 0.016863025724887848, 0.00043928049854002893, -0.015379827469587326, 0.00685478001832962, 0.020938480272889137, 0.011217519640922546, -0.03794848918914795, -0.032630354166030884, -0.012079378589987755, 0.004195713438093662, 0.01570051908493042, -0.011344460770487785, -0.03460795432329178, 0.015941038727760315, -0.026577305048704147, -0.001697827479802072, -0.00601964583620429, -0.0028110609855502844, -0.0032887577544897795, -0.00010058144835056737, 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53,Essential Oils and the Brain Module 3,1108.44,1203.98,"So if you order it now, I know I need to make 30 or 40 or 50 of them or whatever it is to get them out to you. So go ahead and order those now if you'd like to have a DVD mailed to you in the next few weeks for this series. All right, so we'll see you next week on Sunday evening at 8 p.m. to do the last module of the series. Thank you. These slides are already in the Dropbox folder, so you can go download this and start looking at all these research studies I've given you. So you guys have a good evening, and we'll see you next time. [♪ music playing [♪ music playing [♪ music playing [♪ music playing [♪ music playing [♪ music playing [♪ music playing [♪ music playing [♪ music playing [♪ music playing [♪ music playing [♪ music playing aparece Good evening everybody.",190,"[-0.022897791117429733, -0.01956106163561344, -0.00958465039730072, -0.017818398773670197, -0.015251684933900833, 0.01906122826039791, -0.023965002968907356, -0.036042068153619766, -0.018304724246263504, 0.00515369139611721, 0.008767354302108288, 0.02204672247171402, 0.0005492261261679232, 0.024775544181466103, 0.0012462071608752012, -0.007693387567996979, 0.01310375053435564, -0.007956813089549541, 0.007781195919960737, -0.008517437614500523, -0.006963900290429592, 0.002044928027316928, 0.004701139405369759, -0.02381640486419201, 0.008659282699227333, -0.0009279008954763412, -0.003833184717223048, -0.014576233923435211, -0.017750853672623634, 0.002588666044175625, 0.010739671997725964, -0.00908481702208519, -0.005508303176611662, 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54,Essential Oils and the Brain Module 3,1209.0,1327.4,"been going on. We've been through Module 1, we've been through Module 2. Module 1 we covered a lot of the basics in terms of the differences between application methods. And in Module 2 we went into the blood brain barrier, the structures of the blood brain barrier, and then the evidence that we have that essential oil molecules can make it through the blood brain barrier. We also went over the difference between olfactory limbic response and systemic response. So if you haven't seen any of those classes go back and review them, the videos are posted in the group and they are in your folder now. Module 1 and Module 2, the slides and JPEG and PDF format as well as the MP4 videos are uploaded into that folder. You can go download it. If you don't have access to that folder, please Facebook message, private message me and let me know and I'll shoot you the link. Thank you for coming everyone tonight.",197,"[0.005757234524935484, -0.00027013293583877385, -0.006678123027086258, -0.04111061990261078, -0.022558411583304405, 0.012751283124089241, 0.00513210566714406, -0.011023776605725288, -0.021456032991409302, -0.00979368481785059, -0.013618397526443005, 0.007535154465585947, -0.013309193775057793, 0.009074450470507145, 0.010317985899746418, -0.005431226454675198, 0.037615276873111725, 0.01836399920284748, -0.009148390032351017, 0.02124093472957611, -0.012643733993172646, 0.009255939163267612, 0.0009687815909273922, -0.018001019954681396, 0.01621301844716072, 0.01886141300201416, 0.016858311370015144, -0.020353656262159348, -0.03011373057961464, -0.011386754922568798, -0.012751283124089241, 0.020380543544888496, -0.03411993384361267, -0.0013905754312872887, -0.014720775187015533, -0.020488092675805092, -0.005478279199451208, -0.011373311281204224, 0.005387534853070974, -0.003673471976071596, 0.013436907902359962, 0.01840432919561863, 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55,Essential Oils and the Brain Module 3,1339.32,1463.88,"You get 30% off any of my other classes that are at StarfishSense.com. It's coupon codes on the last screen. Just type in 30OFFCLASS. You'll get 30% off. I have other classes if you want to take them. Other series, books, things like that. So here we go. First, we've got to understand the autonomic nervous system. To understand some of this data, I'm going to show you so you understand the differences. You may have learned this a long time ago or recently. This may be knowledge you never heard before, but in any event, we're all going to get on the same page. The autonomic nervous system is the automatic, synch of auto, automatic. So it's involuntary. It's not something you consciously control. It's unconscious. Basically, the functions going on inside your body that your brain takes care of behind the scenes without you knowing about it.",195,"[-0.01763777621090412, 0.0009224847890436649, 0.021334316581487656, -0.018561912700533867, -0.024212338030338287, -0.0036932395305484533, -0.012211783789098263, -0.0359884575009346, -0.013492370955646038, -0.0015825812006369233, -0.0038615642115473747, 0.021809585392475128, -0.005204860586673021, 0.008317215368151665, 0.016924872994422913, -0.008620859123766422, 0.04303828626871109, 0.01700408384203911, -0.010746370069682598, -0.0036899391561746597, 0.005729637108743191, 0.0274336077272892, -0.0012228286359459162, -0.018825950101017952, -0.0013787763891741633, 0.008218200877308846, -0.0024572089314460754, -0.009571398608386517, -0.0009785930160433054, -0.02179638482630253, 0.018601518124341965, -0.015829112380743027, 0.005297273863106966, -0.024093519896268845, 0.007076233625411987, -0.010462528094649315, 0.019486047327518463, -0.006062985863536596, 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56,Essential Oils and the Brain Module 3,1475.44,1579.36,"What we're going to be talking about tonight is a lot of the involuntary, the autonomic nervous system tonight. So it is a division of the peripheral nervous system. Peripheral meaning everything that comes out to the periphery of our body as opposed to our central nervous system. If you look at this picture here, there's different nerves that come in and innervate different organs. The heart, the stomach, the intestines, the bladder, the eye, etc. Smooth muscle cells that go around our arteries and veins, the control blood pressure. So there's a nervous system that innervates or connects to these organs and tissues of our body to control the various aspects of our bodily functions. Now this is all being controlled by the brain through the central nervous system and then through the autonomic.",162,"[-0.018871134147047997, 0.012339310720562935, 0.011422676034271717, -0.0011209542863070965, -0.03669102117419243, 0.006660022772848606, 0.008038179948925972, -0.014896913431584835, -0.0028957317117601633, -0.005089565180242062, -0.02112746424973011, 0.018050650134682655, -0.020230060443282127, 0.011397036723792553, -0.0041184453293681145, -0.0111598651856184, 0.04110112413764, 0.01408925000578165, -0.002394146751612425, -0.0038203787989914417, -0.006070300005376339, 0.0008136734250001609, -0.005493397358804941, 0.008018950000405312, -0.0025511926505714655, 0.013320045545697212, -0.0004943736712448299, -0.027511855587363243, 0.017845528200268745, -0.01744810678064823, -0.006227345671504736, -0.005339556373655796, 0.007980489172041416, -0.022973554208874702, 0.010794493369758129, 0.0039261444471776485, 0.013602087274193764, -0.014896913431584835, -0.01835833117365837, 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57,Essential Oils and the Brain Module 3,1586.88,1706.54,"So it can actually affect these other areas. Digestion, respiration, urination, sexual arousal, all these other effects are all connected to the autonomic nervous system. The hypothalamus is sort of the master control system in the base of the brain, which integrates all the signals from the limbic system and then sends that out through the autonomic system. So the hypothalamus is sort of the central integrator of all these signals. Now remember from our previous modules, the hypothalamus can affect three different axes in terms of hormonal regulation. The HPT, which is the hypothalamus pituitary thyroid, the hypothalamus pituitary gonad HPG, and then HPA, which is the hypothalamus pituitary adrenal. So those three axes are basically hormonal regulation systems that basically originated the hypothalamus in our brain and then control other hormonal systems in our body through those three major systems. 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58,Essential Oils and the Brain Module 3,1718.56,1821.92,"If we're playing a sport, our sympathetic nervous system goes to work. So this is completely different nerves, axons that travel throughout the nervous system and they innervate these organs as well, but it's a different set of fibers that innervate. Now the parasympathetic is the rest and digest or the breed and feed, some people call it, breed and feed or rest and digest. This is where we're slow or as a dampening system, it's slow acting. So the sympathetic is rapid response. So you have to respond to something quickly like you're being attacked or you're playing a sport. Parasympathetic is more slow response and it's really bringing down the levels in our body and causing us to rest, focus our mind, focus our attention, rest our body. 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59,Essential Oils and the Brain Module 3,1831.5,1943.24,"So if the parasympathetic is ramped up and the sympathetic is ramped down, we're in a very restful state. And if the sympathetic nervous system is ramped up and the parasympathetic is ramped down, then we're in a very agitated anxiety fear based state. So it's important to understand the difference between these two different systems. So you can see here, here is a lot of the structures in the limbic system, the amygdala which controls fear, the hypothalamus, remember I told you the central command and control controls three hormonal axis from that, the prefrontal cortex is all connected in the brain and then the brain stem which is at the base of the brain. And then you basically have the parasympathetic which is the rest, restful state and then the sympathetic which is the fight or flight agitated state. 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60,Essential Oils and the Brain Module 3,1955.56,2086.68,"signals to the heart and they can change our heart rate. So one way that scientists use, physiologists use to measure what system is being activated in our body, the parasympathetic or the sympathetic, is by measuring different aspects that they can key in on our heart rate. One of those aspects is heart rate variability which we'll talk about. So if we can measure this principle called heart rate variability or HRV, we can get a good idea as a surrogate measure, an indicator of what's happening with our parasympathetic or sympathetic nervous system. So we'll get into that. So the limbic system is at the central portion of all this, it's being affected by the olfactory receptors in the olfactory bulb and then that sends the olfactory cortex in our brain and then that connects to all these other structures in the limbic system which are here. So here's the limbic system. 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61,Essential Oils and the Brain Module 3,2099.2,2207.84,"brain. Now, the essential oils can modulate these structures in the brain through the limbic system which I just showed you, the olfactory system. Now that's different than the systemic response which is when the essential oil molecules go into our bloodstream, then either through inhalation or topical application or ingestion, they get into our bloodstream and then travel through our bloodstream into our brain, cross the blood-brain barrier, get into the brain tissue. That is different than activating the limbic system and then sending electrical signals to these parts of the brain which then change these parts of the brain, the sympathetic and parasympathetic response. Not that the systemic response can't also do these things. It can. It's just that it's a different mechanism and just because something, a molecule particularly interacts with the olfactory receptor and activates a parasympathetic behavior doesn't mean it's going to do that in a systemic way when it gets into your bloodstream and goes to your brain.",201,"[-0.012909621931612492, 0.012455742806196213, -0.004908379632979631, -0.03389829397201538, -0.029981965199112892, 0.015691254287958145, -0.005404404830187559, -0.023977791890501976, -0.006840608548372984, 0.009628723375499249, -0.01632668450474739, 0.022810673341155052, -0.019905846565961838, 0.00824115052819252, -0.011249721050262451, 0.007190743926912546, 0.054776739329099655, 0.0246780626475811, -0.009486076422035694, 0.017091795802116394, -0.017701290547847748, -0.011009813286364079, 0.014161031693220139, -0.005751298274844885, 0.009687080048024654, 0.01130159292370081, 0.018414529040455818, -0.026376867666840553, -0.035065412521362305, -0.0031431138049811125, -0.004905137699097395, 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62,Essential Oils and the Brain Module 3,2214.48,2319.04,"It might be 66 or 67 beats per minute and then change back to 65 and then 62 and then up to 68. So there's a variation in the heart rate which we call heart rate variability. So we can measure that heart rate variability, how much the heart rate is changing over time in any individual, and then by measuring the frequency at which the heart rate is actually changing, the high frequency components and the low frequency components, what do we mean by that? So if your heart rate is changing slowly over time, let's say it's 65 beats per minute now and in 20 seconds from now it's at 75 beats per minute. Well that's 10 seconds and it has changed its heart rate from 65 to 75. That's a low frequency, but let's say in one second your heart goes from 65 to 75. That's a high frequency response in your variability.",190,"[-0.02091287635266781, 0.0015596788143739104, -0.0072366585955023766, -0.024691253900527954, -0.005990798585116863, 0.010186554864048958, -0.011278643272817135, -0.011222155764698982, -0.040545374155044556, -0.007506542839109898, -0.007374738808721304, 0.04870465770363808, -0.006577639374881983, -0.02154051512479782, 0.011353960260748863, -0.010268147103488445, 0.037758663296699524, 0.04089685156941414, 0.01759895123541355, -0.017887664958834648, -0.012916777282953262, 0.04112280160188675, -0.020059289410710335, 0.0026125404983758926, -0.02929811179637909, 0.011033864691853523, 0.002319120103493333, 0.007845466956496239, 0.01326825376600027, 0.0008371113217435777, 0.020712032914161682, 0.011981597170233727, -0.019783129915595055, -0.011774476617574692, -0.010789086110889912, -0.02228112705051899, -0.0014694560086354613, -0.0032323324121534824, 0.007870572619140148, -0.013406334444880486, 0.016582179814577103, 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63,Essential Oils and the Brain Module 3,2329.44,2451.2,"So you can actually pull out the high frequency components and the low frequency components of heart rate variability and from that we can actually ascertain if the parasympathetic or the sympathetic part of our nervous system is being activated and I'll show you what I mean by that. The high frequency components, meaning when our heart rate changes very fast, is associated with the parasympathetic or the rest and digest, so the peaceful state, which sounds kind of counterintuitive, right? So if your heart rate is changing, fluctuating quickly, not that your heart is beating fast, it's beating at a normal speed, it's just that the speed is changing at a high rate, meaning that it could go from 65 to 66 to 63 to 66 to 63 to 66 beats per minute and it's doing that fluctuation very fast.",176,"[-0.017011815682053566, 0.016537126153707504, 0.008056877180933952, -0.015946973115205765, -0.009352649562060833, 0.01444593071937561, -0.019218476489186287, -0.033690065145492554, -0.028147753328084946, -0.008416101336479187, -0.009134548716247082, 0.04790506511926651, -0.01150157768279314, -0.02007804624736309, 0.007595018483698368, -0.008281392976641655, 0.0389757864177227, 0.012778105214238167, 0.009096060879528522, -0.007813118398189545, 0.0045031276531517506, 0.02499171532690525, -0.01846154034137726, -0.008711177855730057, -0.020655371248722076, 0.01643449068069458, -0.001791308168321848, 0.003131982870399952, 0.0016317422268912196, -0.0018330038292333484, 0.012502272613346577, 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64,Essential Oils and the Brain Module 3,2457.48,2588.36,"I know that sounds counterintuitive, but get that into your head, okay? So the actual high frequency component decreases in anxiety and stress. When it increases, that means you're in a restful state. People that have post-traumatic stress disorder, PTSD, actually have a very reduced level of the high frequency component of the heart rate variability. Now the other aspect is the low frequency, so when the heart rate is changing slowly, so if you're doing 65 beats per minute and then 10 seconds later it's 75 and then it comes back down to 65. If there's that long range change in your heart rate, that's a low frequency change, that's actually associated with sympathetic or flight or flight. I know that sounds counterintuitive. Again, but if you're in a fight or flight, anxious, anxiety, fear state, then your heart rate variability will have a low frequency change to it over time.",192,"[-0.021645134314894676, 0.0074235848151147366, 0.006372286472469568, -0.030287709087133408, -0.01727225072681904, 0.005511253606528044, -0.017594734206795692, -0.03743395581841469, -0.024276604875922203, -0.004466405138373375, -0.006810864899307489, 0.042619504034519196, -0.011796469800174236, -0.007978257723152637, 0.008468433283269405, -0.004060075152665377, 0.0410199798643589, 0.018497688695788383, 0.009655174799263477, -0.018691180273890495, 0.003908507525920868, 0.03743395581841469, -0.00862322561442852, 0.0007288141059689224, -0.008797367103397846, 0.00650128023698926, -0.003818212077021599, 0.0018268725834786892, 0.004285814240574837, -0.0074235848151147366, 0.02377353049814701, 0.004740516655147076, -0.024973170831799507, -0.007068851962685585, -0.012622028589248657, -0.030932677909731865, 0.004775989800691605, 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65,Essential Oils and the Brain Module 3,2598.76,2706.88,"This is the heart rate over time and beats per minute on this axis and you can see here's time in seconds. So 250 seconds is like 4 minutes. So here's 4 minutes of time being expired. This person you're measuring their heart rate over time. So this is how many beats per minute. You can see it's fluctuating between 65 up to 80, you know there's spikes. So their heart rate is going up, their heart rate is coming down and it's fluctuating like this. Alright, now, so this is like the average right here, somewhere around 70 beats per minute. Okay, over time.",134,"[-0.02145295776426792, -0.0034163740929216146, -0.008654814213514328, -0.037090279161930084, -0.011868390254676342, 0.003177695907652378, -0.011768550612032413, -0.025221887975931168, -0.02932777814567089, -0.01188086997717619, -0.014277012087404728, 0.038537949323654175, -0.03838818892836571, -0.017259709537029266, 0.013390938751399517, -0.006926347501575947, 0.02605804242193699, 0.008810813538730145, 0.019094254821538925, -0.018520180135965347, -0.003903090488165617, 0.008511295542120934, -0.02610796131193638, 0.01959345117211342, -0.027006514370441437, 0.0028251386247575283, 0.003500613383948803, 0.003569253021851182, 0.015500042587518692, -0.03167400136590004, 0.02568364515900612, 0.009097850881516933, -0.030675606802105904, -0.005553558003157377, -0.002628579968586564, 0.000296202750178054, -0.0120618287473917, 0.0024788212031126022, -0.00871721375733614, -3.066351928282529e-05, 0.01030840165913105, -0.010158643126487732, -0.008592414669692516, 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66,Essential Oils and the Brain Module 3,2713.08,2842.8,"the HRV, and if you see more peaks here, that's more lower frequency components to the HRV. Remember, higher frequency components are associated with rest and relaxation, lower frequency components are associated with agitation and stress. Is this all making sense? Can everybody still hear me? Everyone's still with me? So here's somebody who's not taking in essential oils, is not taking in lavender, and then they take in lavender through aromatherapy, and you can see that the high frequency component spikes of the heart rate variability, and you can see the low frequency component drops here. So this is looking at the frequency, that's looking at how fast are the heart rate fluctuating. So if it's fluctuating really, really fast, then that ups this peak here. If it's fluctuating really slow, like say a big long wave like this, that would up these lower frequency components here. 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67,Essential Oils and the Brain Module 3,2853.28,2977.12,"system. Now if you look at the high frequency component, this part here, and you graph that over time, you see that the lavender exposed person has a higher, and this was done I believe in 10 individuals, so this is an average of 10 different people, not just one person. So you can see the higher frequency component goes up for the lavender, meaning the high frequency component, remember when it goes up, that means we're in a more parasympathetic activity or more rest and relaxation than the person with the control. They have a lower high frequency component. Now if you take the ratio of the low frequency to the high frequency, that's what we really care about, you can see that the lavender, people that take lavender have a lower ratio of LF to HF, meaning that they have higher parasympathetic activity compared to sympathetic. 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68,Essential Oils and the Brain Module 3,2987.12,3114.46,"to lower stress levels. So everything is correlating the way you would expect it to. Now if you look at what's happening inside the brain of these folks taking lavender and you do a PET scan, it's called positron emission tomography, PET, you can actually look at what regions of the brain are metabolic active or more active or less active based on how much glucose is being uptaken by the tissues of the brain. So measuring how much glucose is being used in the different cell volumes of the brain tells you what the level of metabolic activity in that portion of the brain. Is that part of the brain being activated or deactivated? You can do that through a PET scan. There are other ways you can do this like through an FMRI. You can use other methods too. But this is one way you can look at it. So PET scans monitor glucose metabolism like I said earlier, which relates to relative level of activity.",189,"[-0.004852639976888895, 0.0005328608676791191, 0.039180099964141846, -0.030154317617416382, -0.020372113212943077, 0.011961725540459156, -0.010109132155776024, -0.027282478287816048, -0.027820946648716927, -0.017000265419483185, -0.011243765242397785, 0.03505183011293411, -0.01031426340341568, 0.015282290056347847, -0.0035769790410995483, -0.01542331837117672, 0.05130849406123161, 0.006577025633305311, -0.014679716899991035, -0.02142341248691082, -0.012051470577716827, 0.012788661755621433, 0.0011899224482476711, 0.006144326645880938, -0.0052308510057628155, 0.022692661732435226, 0.014448943547904491, -0.02256445586681366, -0.011782235465943813, -0.011410434730350971, 0.002950366586446762, 0.010634781792759895, -0.022320860996842384, -0.02279522828757763, -0.00019501506176311523, -0.027359401807188988, 0.0065642050467431545, 0.0032740896567702293, -0.0018702215747907758, 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69,Essential Oils and the Brain Module 3,3122.44,3263.62,"The posterior cingulate, this part of the brain that was activated deals with cognition and awareness, mental activity. The thalamus is basically a relay station or a hub that relays all the sensory information coming into the body between the different, so it basically takes in all the sensory information coming in from our eyes and from our skin and all this sensory information and then parses it and directs it where it needs to go. The cerebellum has a lot to do with fine motor control, very specific responses in fine motor control and in orbital front and coordination and that type of thing. The orbital frontal cortex is basically decision making and cognitive processes. So these are all activated. So this, but with the overall conclusion is this person has overall more improved mental awareness and mental function, which makes sense, right? Because if you're in a relaxed and relaxed state, that means you're sleeping. 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70,Essential Oils and the Brain Module 3,3272.08,3377.16,"And then the frontal eye field, which deals with eye movement. So if you're in a fight or flight response, you have increased eye movement, right? So you can see what's happening around you. And so that's when people get nervous or anxious or whatever, you see their eyes moving around a lot is because of that frontal eye field. So you see people with exposed lavender decrease in the frontal eye field of the brain and also decrease in the central gyrus, which is the sensory motor area. That means that the body has decreased sensory inputs from the rest of the body and decreased motor activity to the muscles. So less sensing of what's going on around you in terms of where are my legs and what am I touching right now? All that kind of physical information, sensory information is being decreased. And then there's less response in terms of going the other way, controlling those muscles. And then decreased eye movement. 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71,Essential Oils and the Brain Module 3,3387.92,3482.88,"A lot of research has been done on lavender by the way, just because it's a very common essential oil that a lot of people use and so it's been studied a lot. So there's more data about lavenders than say other essential oils, but there's plenty of data out there about other essential oils too, citrus oils, rosemary, etc. So don't have tunnel vision here and say, well lavender is the one oil I should be using because he's showing me this data about lavender. So I don't want you to get that narrow of a field of focus. I just want you to see how these things work. A lot of the constituents that are in lavender like linalyl acetate and linalool appear in other essential oils too. So these terpenoids and terpene molecules that are in these essential oils tend to have the same types of effects in different bodily systems.",185,"[0.008872048929333687, 0.013730705715715885, 0.016118094325065613, -0.04668956249952316, 0.0010944881942123175, 0.013795229606330395, -0.006565316114574671, -0.019512055441737175, -0.01576966419816017, -0.021344536915421486, -0.02217044308781624, 0.023112494498491287, -0.02826150879263878, 0.014040420763194561, -0.007039567455649376, 0.006191077176481485, 0.05543901398777962, 0.003977904096245766, 0.015640616416931152, 0.01406623050570488, -0.012053081765770912, -0.009020454250276089, -0.024777213111519814, -0.006884709931910038, -0.014143658801913261, 0.02833893708884716, 0.030326277017593384, -0.03538495674729347, -0.027435602620244026, 0.0031987768597900867, 0.003842403879389167, 0.028029222041368484, -0.008213904686272144, -0.019357196986675262, -0.0037520702462643385, -0.01926686428487301, 0.012808012776076794, -0.020467011258006096, 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72,Essential Oils and the Brain Module 3,3490.92,3583.42,"So don't get so hung up on the fact that I'm just showing you data about lavender. So what are some of the mechanisms of actions of how lavender is affecting the nervous system? So there's a couple of things that they've looked at molecularly, what's happening at a molecular level. Linalool is a constituent found in lavender and it can inhibit acetylcholine, which is a neurotransmitter release and alters ion channel function at the neuromuscular junction. Meaning that when axons or nerves enter into your muscular tissue, they have to do the synapse there at the neuromuscular junction, the electrical activity and that's done through acetylcholine. So linalool can actually inhibit acetylcholine release there. 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73,Essential Oils and the Brain Module 3,3591.8,3706.56,"that go to the parasympathetic system. So also the cholinergic system is play a role. Lavender has analgesic, which is pain relief, anti-anxiety, reduced anxiety, reduced depression and anti-convulsant activity. So spasmodic response or convulsions can be driven down by reducing the cholinergic system here, acetylcholine, and lavender can do that. Lavender has the ability to block the cholinergic system. Also lavender and linalool, which is a constituent in lavender, they have strong antioxidant capabilities in neural tissue and so a lot of the neurodegenerative disorders like Alzheimer's and dementia are caused by oxidants and oxidation in the brain and lavender can be a neuroprotective to the brain by blocking oxidation events and so it can help with neurodegeneration disorders like Alzheimer's. And it's been shown to have a protective effect against ischemia, reperfusion, injury.",195,"[-0.00993429683148861, 0.023800095543265343, 0.016200952231884003, -0.021148310974240303, -0.033430952578783035, 0.007948757149279118, -0.02117469720542431, -0.04694054275751114, -0.009769384749233723, -0.011748328804969788, -0.00788938906043768, 0.02266550064086914, -0.007427635136991739, 0.013575552962720394, -0.018733998760581017, 0.03277130797505379, 0.04794320836663246, 0.014736533164978027, 0.014894848689436913, 0.013813026249408722, -0.00028158718487247825, 0.015897514298558235, 0.011029312387108803, -0.007757458835840225, -0.008192826993763447, 0.019235331565141678, -0.005818094126880169, -0.027309421449899673, -0.02572626806795597, 0.008892053738236427, -0.010310295969247818, -0.008786509744822979, 0.004469114355742931, -0.01605582982301712, -0.013549167662858963, -0.026478266343474388, 0.016398847103118896, -0.013628325425088406, -0.008087283000349998, 0.008179633878171444, 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74,Essential Oils and the Brain Module 3'Essential Oils and the Brain Module 2,0.0,3727.6,"It would be something systemic. So it gets through the blood-brain barrier, then gets into the limbic system of the brain and then the molecules actually interact with the dopamine receptor themselves directly, rather than electrical stimulation through the olfactory system. See the difference? So then also lavender can modulate GABA receptors, GABA-based neurotransmission. There's GABA-A and there's GABA-B receptors. But the basic GABA is a receptor that turns down the nervous system. So it reduces activity in the nervous system. So GABA is a neurotransmitter that turns down the volume of our nervous system. So lavender can actually modulate that and help tune things down in the GABA response. So those are some examples of different mechanisms of action of how linalool or lavender itself can affect the central nervous system and other nerves in our body. And I would venture to guess that these are just some of the mechanisms of action. They don't know all of them right now.",200,"[-0.0012445248430594802, 0.016950659453868866, 0.01886785589158535, -0.026073869317770004, -0.018325751647353172, 3.5043580282945186e-05, -0.02144615538418293, -0.018087755888700485, -0.02089082822203636, -0.0044822730123996735, -0.008501773700118065, 0.008191055618226528, -0.017955536022782326, 0.014240141026675701, -0.015046685934066772, 0.017096102237701416, 0.044240958988666534, -0.009182709269225597, 0.0010371040552854538, 0.0046376315876841545, 0.0005144201568327844, -0.009367818012833595, -0.001550284563563764, -0.007814227603375912, -0.010452025569975376, 0.029485156759619713, 0.008554662577807903, -0.03289644420146942, -0.025941649451851845, 0.029802486300468445, -0.007106848526746035, 0.014967353083193302, -0.0023948426824063063, 0.009420705959200859, 0.00823072250932455, -0.03173290565609932, 0.002523757517337799, -0.010392526164650917, -0.012243612669408321, -0.006042473949491978, 0.012593996711075306, -0.0007305179024115205, 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75,Essential Oils and the Brain Module 2,134.5,226.78,"So people that say, hey, no studies have ever been done on the central wells. That's a bunch of hoo-ha, right? So there's plenty that just haven't looked. So we're going to share some of those with you tonight. So here's a clinical study that was done once per day, 80 milligram ingestion of lavender. They looked at the anxiolytic effect. So when you see that word, what that means is anxiolytic is something that reduces anxiety. That's all that means. So it was superior. They did 221 patients that were suffering from anxiety. They had a greater reduction in anxiety compared to the placebo. So again, it's not a placebo effect. And in addition, other things like restlessness, their sleep patterns, we'll talk about sleep here in a second, of how lavender can help with sleep, and quality of life factors all improved in this consortium of 221 patients.",196,"[0.0059026083908975124, 0.043851736932992935, 0.044010911136865616, -0.034832023084163666, -0.01022676657885313, 0.009941584430634975, -0.04276406764984131, -0.04740656912326813, -0.018994461745023727, -0.012945945374667645, -0.0183577761054039, 0.018596531823277473, -0.0007875671144574881, 0.016328338533639908, -0.014418281614780426, 0.022363590076565742, 0.03775016590952873, 0.0007200021645985544, 0.015081495977938175, 0.0017177254194393754, -0.004214727785438299, -0.0033044659066945314, -0.014325431548058987, 0.004698874428868294, -0.023212505504488945, 0.012594441883265972, 0.021395297721028328, -0.026687748730182648, -0.00791878066956997, -0.008383030071854591, 0.002936381846666336, -0.005318979732692242, -0.030189521610736847, -0.008270284160971642, 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76,Essential Oils and the Brain Module 2,234.38,344.18,"of reduction of anxiety and improved sleep and quality of life. Now here's a six week intake of oral lavender oil preparation. And actually gave this a drug name called Slaxan, the 80 milligrams a day, and they compared it to lorazepam, which is for anxiety. This was compared to an actual drug. These adults had anxiety disorder and they found out that the lavender actually acted about the same as a half a milligram today of lorazepam in terms of reducing anxiety. So here's an actual trial where they compare it to an actual drug, which I thought was interesting. And again, the references are at the end of this presentation, so you can go look these up. Here's 36 patients that were in an intensive care unit. They had lavender oil diluted 1% as aromatherapy and they had alleviation of anxiety and mood improvement in these 36 patients that were in the ICU.",189,"[0.01962920092046261, 0.027336861938238144, 0.028376996517181396, -0.036031316965818405, -0.012574956752359867, 0.014468533918261528, -0.03936507925391197, -0.03339097648859024, -0.014695229940116405, 0.00011418140638852492, -0.020389297977089882, 0.0198825653642416, -0.011308126151561737, 0.011401471681892872, -0.025843335315585136, 0.03299092501401901, 0.03157740831375122, 0.0028970404528081417, 0.007794339209794998, -0.01258162409067154, -0.01280165184289217, 0.006894222926348448, -0.006297479383647442, -0.003130404045805335, -0.01932249404489994, 0.009454553946852684, 0.02285628393292427, -0.021816149353981018, -0.020029252395033836, 0.00394050870090723, -0.0010751388035714626, -0.009087839163839817, -0.01904245838522911, 6.23517989879474e-05, -0.01713554561138153, -0.010954746976494789, 0.008007700555026531, 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77,Essential Oils and the Brain Module 2,353.9,467.66,"So here they were using tea tree, rosemary, and lavender as a blend. And so they had better mood scores and reduced psychological stress in this long stay environment in the hospital. Here's another study that they looked at lavender aromatherapy at 2% diluted concentration on anxiety and depression in the high-risk postpartum woman showed a significant improvement of Edenberg postnatal depression scale and generalized anxiety disorder scale after four consecutive weeks of administration of lavender. So postpartum depression is a big thing and this actually showed a better improvement in women that would normally suffer from postpartum depression. Another study looked at dental patients and anxiety and people have high anxiety when they go to the dentist and lavender was able to help with that anxiety. So preoperative anxiety also if you're going to a situation where you're going to have an operation you have a lot of anxiety they showed that exposure to lavender can reduce that anxiety in that study. Here's a good one.",195,"[0.0020581844728440046, 0.020889827981591225, 0.014014862477779388, -0.03963371366262436, -0.02494327537715435, 0.00941168237477541, -0.020532170310616493, -0.020055294036865234, -0.01683637872338295, -0.012690206058323383, -0.025989754125475883, 0.018108049407601357, -0.017233775928616524, 0.005275443196296692, -0.021048786118626595, 0.014134081080555916, 0.04723723977804184, 0.005209210328757763, 0.0006118255550973117, -0.004487272817641497, -0.022095264866948128, 0.017088064923882484, -0.017048325389623642, 0.006749122869223356, -0.016293270513415337, 0.02475782297551632, 0.024333933368325233, -0.026002999395132065, -0.009868687950074673, 0.005179405678063631, -0.004096499178558588, 0.003642804455012083, -0.019710883498191833, -0.03497092053294182, -0.022240975871682167, -0.025897027924656868, -0.0001536808122182265, 0.005563555750995874, 0.02940736711025238, 0.0022436364088207483, -0.005139665678143501, -0.015458737500011921, 0.0019985749386250973, 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78,Essential Oils and the Brain Module 2,477.58,606.7,folks with low anxiety but the folks that had extreme anxiety it didn't work as well. Okay. So let's talk about electroencephalography EEG in lavender. That's when they put that cap on your brain and it has all the electrodes that go around and they measure the electrical response of your brain. So when your brain is working there's electrical activity going on there's electromagnetic waves being given off from your brain electrical activity you can measure and you put an EEG cap on with little electrodes that go around your skin. 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79,Essential Oils and the Brain Module 2,614.78,711.54,They're very small in terms of voltage you're talking about millivolts of electrical activity but you can actually measure the EEG pattern and you can get idea of the alpha wave the beta wave the gamma and the delta theta waves which are different frequency waves in the brain and each one of those frequencies and waves alpha beta gamma delta can tell you something about what's happening with the person as well as what area of the brain is being activated at any given time. So a lot of studies you'll see in the literature they'll do an EEG study and measure the alpha response to beta the gamma the delta. Okay. So in these types of studies let's look at what they've looked at in lavender. So lavender affects human EEG pattern accompanied with its anxiolytic effect. 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80,Essential Oils and the Brain Module 2,720.02,832.36,Both the alpha and the theta response are increased in folks that use lavender. Inhalation of lavender in 40 healthy adults diluted to 10% concentration for three minutes increases alpha power of EEG decreases anxiety and improves mood that was one study. In 20 participants inhalation of lavender diluted to 10% increases the power of the theta and alpha wave activities in all brain regions. Now this one was interesting this study here in certain people they you can look at asymmetry in EEG activity meaning one side of the brain might be more active than the other. This asymmetry in the EEG pattern can be indicative of other mental disorders. So somebody might have some kind of anxiety disorder that they're plagued with. It could be that at an early age if you do an EEG on them you'll see an asymmetry where the right side of the brain shows a higher EEG signal than the left.,178,"[0.008105892688035965, 0.020815616473555565, 0.017287323251366615, -0.0459071584045887, -0.019241657108068466, 0.0020035195630043745, -0.0303511880338192, -0.04073932394385338, -0.0077779837884008884, -0.020094217732548714, -0.02783285267651081, 0.024894794449210167, 0.005482626147568226, 0.012027675285935402, -0.003151198383420706, 0.00813212525099516, 0.03759140148758888, -0.005030112806707621, 0.00954213086515665, 0.0050366707146167755, -0.018179234117269516, 0.012972051277756691, 0.0039808060973882675, 8.018381777219474e-05, -0.03942769020795822, 0.009201105684041977, 0.010106132365763187, -0.02848866954445839, -0.01821858249604702, -0.00024552131071686745, 0.01471652276813984, -0.007922263815999031, -0.019635146483778954, -0.014152520336210728, -0.015490386635065079, -0.018598956987261772, 0.013824611902236938, 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81,Essential Oils and the Brain Module 2,838.54,940.58,So this asymmetry they showed that once people take lavender that the left side which may be lower in these individuals can be increased with respect to the right and that can restore the equilibrium between the left and the right sides of the brain. So this asymmetry can actually you know reverse the symptoms of these folks with the asymmetry to begin with. So that's another study you can go look at. Lavender and sleep now it brings sleep into this because that's all being controlled by the brain and this class is about essential oils in the brain so lavender and sleep any kind of sleep is going to be affected by the brain. So lavender can help with sleep and that's why you'll see a lot of folks diffusing lavender at night when they go to bed. So there's studies that showed that sleep quality was improved in 15 healthy students and 64 ischemic heart disease patients as well as 34 midlife women with insomnia.,189,"[0.009235263802111149, 0.029957175254821777, 0.02780424989759922, -0.03925151377916336, -0.020387157797813416, 0.020807240158319473, -0.030009685084223747, -0.023367121815681458, -0.02273699641227722, -0.008926765993237495, -0.021778682246804237, 0.02138485386967659, 0.00896614883095026, 0.013692082837224007, -0.011795145459473133, 0.01656702719628811, 0.046996794641017914, 0.0030406794976443052, 0.019258184358477592, -0.007824047468602657, -0.016895215958356857, 0.006347192917019129, -0.004128629341721535, 0.0004414154391270131, -0.02299954928457737, 0.02769922837615013, 0.01941571570932865, -0.014860439114272594, -0.01146695576608181, -0.00040839132270775735, 0.0061699701473116875, -0.003833258291706443, -0.008395098149776459, -0.0166064091026783, -0.015149245969951153, -0.007929068058729172, 0.015805626288056374, 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82,Essential Oils and the Brain Module 2,949.54,1048.26,Here's another study with 10 individuals with insomnia couldn't sleep and verified by a score of 5 or more on the Pittsburgh Sleep Quality Index were treated with lavender odor. 6 to 8 drops of lavender oil added each night to the cartridge improved the PSQI score by negative 2.5 points. More notable improvements were seen in females and younger participants. Milder insomnia also improved more than severe ones. Okay that's another study for you. Oral lavender so this is ingestion oil preparation 80 milligrams a day showed a significant beneficial influence on quality and duration of sleep and improved general mental and physical health without causing any unwanted sedative or other drug specific effects in 221 patients suffering from subsyndromal mixed anxiety disorder. 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83,Essential Oils and the Brain Module 2,1054.78,1130.14,going to look at lavender and pain again pain is controlled by the brain a lot and in the nervous system so that's why we're including it in this study. Okay so let's look at lavender and pain. It has been shown in a foot massage using lavender essential oil in a hundred ICU patients of whom 50 percent were receiving artificial ventilation was effective in lowering blood pressure heart rate respiratory rate wakefulness and pain. So lower their blood pressure lower their heart rate their respiration rate wakefulness during the day and then also pain reduction in these hundred ICU just by rubbing lavender oil on their feet. So this is proof that you know going through the foot works. 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84,Essential Oils and the Brain Module 2,1139.46,1228.98,"So if you're under pain right if you have pain and you're looking for long-term pain relief you don't want something that's going to clear out of your system in 20 minutes you want something that's going to last a long time if we're the bottom of the foot. Here's a study they looked at ulcerations with patients had ulcers on their skin and the lavender oil and 115 patients they got pain relief from the lavender as well as the ulcer size was reduced and healed faster than the placebo groups. So here's a blend you're going to take a note of this. This is a massage that was done with lavender, claryseeds and marjoram a 2-1-1 ratio 48 patients outpatients with menstrual cramps, alleviated their pain and reduced the duration of menstrual cramps.",170,"[0.011027253232896328, 0.02243887074291706, 0.03175637125968933, -0.0284959077835083, -0.015374536626040936, 0.005026545841246843, -0.03663380816578865, -0.03578555956482887, -0.022531647235155106, -0.009794640354812145, -0.011265823617577553, 0.025208938866853714, -0.009721743874251842, 0.012001415714621544, -0.016315564513206482, 0.03098764270544052, 0.04564647004008293, 0.009701862931251526, 0.029317650943994522, -0.011511021293699741, -0.0018190991831943393, 0.015639614313840866, -0.005659420043230057, -0.011882130987942219, -0.02322085201740265, 0.029291141778230667, 0.01119292713701725, -0.03178287670016289, -0.014711841009557247, -0.0019897434394806623, -0.003222357016056776, 0.011020626872777939, -0.0033101642038673162, -0.011597171425819397, -0.05237945541739464, 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85,Essential Oils and the Brain Module 2,1237.82,1333.54,"So ladies this is a big one take note lavender, claryseeds and marjoram 2-1-1 ratio if you have trouble with menstrual cramps menstruation try this blend here it may help. So this study here aromatherapy with lavender was also reported as successful in safe clopamentary therapy and reduction of pain after the cesarean section 200 term pregnant women after episiotomies in 60 women as well as in perineal discomfort following normal and childbirth 635 women. So these are three different studies pain in pregnant women or they had episiotomies or they had discovered following childbirth the lavender oil was used and showed a decrease in pain. Continuing on pain lavender aromatherapy through an oxygen face mask with two drops of 2% lavender oil was shown to reduce demand for opioids in 25 patients after immediate post-opteroperative breast biopsy surgery and for other analgesics in 54 patients undergoing laparoscopic adjustable gastric banding.",200,"[-0.015296799130737782, 0.00829747598618269, -0.0010045634116977453, -0.03543825447559357, -0.002303553279489279, 0.010438760742545128, -0.026163816452026367, -0.02139945887029171, -0.01659495197236538, -0.02338014729321003, -0.002159685827791691, 0.013182280585169792, -0.021386075764894485, 0.008839488960802555, -0.018080469220876694, 0.03768660128116608, 0.03878400847315788, 0.0016645138384774327, 0.009475182741880417, 0.0005298841861076653, -0.008404540829360485, 0.0059922500513494015, -0.016367441043257713, 0.005928680766373873, -0.023728106170892715, 0.012834321707487106, 0.014025411568582058, -0.03356463089585304, -0.004566957708448172, -0.0035833052825182676, 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86,Essential Oils and the Brain Module 2,1343.98,1457.22,know people are addicted to opioids lavender can be a way to help people to maybe get off of opioids. Some of you know everyone in our family can probably think of someone in our family who's been affected by that so just good news. 47 patients suffering from migraine attacks reported significant reduction of pain severity and associated symptoms. So this is migraine and how many of you have migraines after 15 minutes inhalation of lavender two to three drops of lavender essential oil rubbed onto the upper lip and early stage of the attack. So the key here this study was you had to get it at the very early stage like as soon as you start to feel that migraine coming on you do this with the lavender can help it. After the migraine starts if you wait too long then it wouldn't have that effect. 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87,Essential Oils and the Brain Module 2,1460.3,1547.98,So that basically gives you a pretty good overview of lavender and how it interacts with the nervous system and what we know about it in terms of clinical studies. There's a lot more data out there that's not all of it okay this is just some of it. So I can't show you everything it would be you know hundreds of pages and we would never get through the class but I'm helping you understand how these things work and you can go to PubMed you can go to Google and you can type in these things and you can start to read these studies for yourself. So here's the references there's okay three slides yeah three slides with references to the studies that were used in this presentation. All you have to do is cut and paste. When you get the PDF of this which will be in the folder all you have to do is cut and paste the title of this study and put it into Google and it'll pull up the paper you can read the abstract.,195,"[-0.005372466053813696, 0.0257223192602396, 0.0389438271522522, -0.0290113165974617, -0.02257746085524559, 0.009362504817545414, -0.004376594442874193, -0.022249871864914894, -0.01935398206114769, -0.006695927120745182, -0.00931664276868105, 0.014112550765275955, -0.02666577696800232, 0.02105744555592537, -0.010561482049524784, -0.006505925208330154, 0.035930003970861435, -0.012972540222108364, -0.011478732340037823, -0.004121074452996254, -0.014112550765275955, -0.006761445198208094, -0.007521452382206917, -0.015514633618295193, -0.013431165367364883, 0.028854073956608772, 0.013522890396416187, -0.023612642660737038, -0.024634722620248795, -0.00925112422555685, 0.007534556090831757, 0.006722134537994862, -0.012179773300886154, -0.015658773481845856, 0.013221507892012596, 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88,Essential Oils and the Brain Module 2,1559.38,1661.98,So I'm starting to teach you and train you on what these different terminologies mean. So if you see a study and you're talking about HRV heart rate variable what does that mean? So you'll start to see that in a lot of these studies. Now you know how to interpret that data. You're talking about the high frequency you're talking about the low frequency component. You're talking about alpha waves or beta waves. You're talking about the cingulate gyrus what does that mean? So go back to these notes here and you can actually this will help you interpret other research studies that you may want to look into. You might be some of your family with a very specific brain condition and you want to figure out is there something I can find out in the literature about it and you do a search you start to read the paper and you go I don't understand any of this stuff.,184,"[-0.011295665986835957, 0.02122962847352028, 0.025094276294112206, -0.019660424441099167, -0.0062379054725170135, 0.011016841046512127, -0.001313072512857616, -0.005602443125098944, -0.029075641185045242, -0.019401052966713905, -0.009830212220549583, 0.03130624443292618, -0.021281501278281212, 0.009778337553143501, 0.004720577038824558, -0.032188110053539276, 0.03317372500896454, 0.012793541885912418, 0.019608549773693085, -0.010433252900838852, -0.012391514144837856, 0.0032356702722609043, -0.02251351997256279, -0.007943278178572655, -0.028219712898135185, 0.03553401306271553, 0.01792263053357601, -0.01274815108627081, -0.011781989596784115, 0.002225738950073719, 0.01810419000685215, 0.023019297048449516, -0.004312065429985523, 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89,Essential Oils and the Brain Module 2,1674.3,1770.7,"go to starfishcents.com and get 30 off class. Another exciting thing, I'm starting a CBD class. CBD oil and we're going to learn all about CBD and what it means, what it can do, what it can't do, some of the misconceptions, all about CBD. So it's going to be multiple modules, probably four modules on CBD. It's going to start next week on Saturday. We're going to talk about endocannabinoids, phyto-cannabinoids, cannabinoid receptors. We're going to talk about the on-flourage effect. We're going to talk about it all, different extraction methods, the different types of CBD, drug testing, THC, all of that stuff. So but I can't sell that class on Etsy through starfishcents.com because Etsy looks at the word CBD and it says eh and it just takes the listing down and won't let me even put it up there.",192,"[-0.021047135815024376, 0.00233949045650661, -0.008417529053986073, -0.020159685984253883, -0.02042459510266781, 0.0007040823111310601, -0.03454432263970375, 0.004715405870229006, -0.0034305902663618326, 0.007589684333652258, -0.003781596664339304, 0.02333861030638218, -0.016278747469186783, 0.012013688683509827, 0.0024073736276477575, 0.02345781959593296, 0.04945877939462662, -0.0014512125635519624, -0.012364694848656654, -0.01862320490181446, -0.0025365175679326057, 0.012444168329238892, 0.0020017295610159636, 0.0005832168972119689, -0.018331803381443024, 0.018874868750572205, 0.01808013767004013, 0.002683873986825347, -0.028239453211426735, -0.016093309968709946, 0.0002636686840560287, 0.032133638858795166, -0.013762097805738449, -0.028583837673068047, -0.007218809798359871, 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90,Essential Oils and the Brain Module 2,1773.46,1865.54,"So I had to create a separate link for people to sign up for the CBD class. So if you go to the Facebook group, Shedding Light on Essential Oils, the big group that we have, okay, let me show you here. This group, Shedding Light on Essential Oils, the big group, public group, there's a post on the top that shows you how to sign up for the CBD class. There'll be a Facebook group just like this one for the CBD class and you'll be able to join the class but you won't be able to order this class on starfishcents.com. You'll have to do it through the link that's, the special link, custom link I made that's posted on the top of this group if you want to join. So if you want to join the class, if you have friends, family, other team members that want to learn about CBD, that's where you go and it will start next week.",199,"[-0.0018212890718132257, 0.005509975831955671, -0.004090490285307169, -0.0436318963766098, -0.016783524304628372, -0.004610858391970396, -0.01438587810844183, -0.012060688808560371, 0.0009822775609791279, 0.0036590455565601587, -0.006738440133631229, 0.0165727436542511, -0.014333182945847511, 0.02019556052982807, 0.0021901577711105347, 0.027032803744077682, 0.03641260787844658, -0.025741763412952423, 0.006320169661194086, 0.008727696724236012, -0.013714010827243328, 0.004726130049675703, 0.003675512969493866, 0.00949836801737547, 0.006738440133631229, 0.0008859435329213738, 0.02521480806171894, -0.009491781704127789, -0.016164353117346764, -0.0034746110904961824, 0.005921659525483847, 0.027032803744077682, -0.0047656516544520855, -0.019088953733444214, -0.007337851915508509, -0.0021456959657371044, 0.0009238184429705143, 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91,Essential Oils and the Brain Module 2,1873.1,1991.94,"So you guys have a good night. Again, use the code 30OFFCLASS at Starfish Sense if you're going to get any classes tonight. So we'll see you next time, next week. You guys have a great week. Thank you for coming each week and I'll see you soon. Good night. Say, Good night. That's it for this video and thanks for watching. rage rage Lego bluetooth Rosa Hey everybody, we're going to start in one minute. Sorry for the delay. Something went wrong with the software I was using and I finally figured out what was wrong. But anyway, we're going to get started here in about 60 seconds. So jump on, grab something to drink, and we'll get started here in a minute. All right? Thanks for watching. Good evening. Happy New Year everybody. Getting back into the swing of things here. We're going to get into module two of my new series, essential oils and the brain.",199,"[0.004711021203547716, 0.008752902038395405, -0.019371286034584045, -0.0503680482506752, -0.015829572454094887, -0.006471740081906319, -0.0007308165659196675, -0.0037748999893665314, -0.008414952084422112, -0.01386946253478527, -0.0021442919969558716, 0.026657486334443092, 0.014694060198962688, 3.47982750099618e-05, 0.011706583201885223, -0.01126048993319273, 0.029009616002440453, -0.0026867014821618795, 0.016505472362041473, 0.009956003166735172, 0.009428801015019417, 0.037417810410261154, 0.005714732222259045, -0.0011388910934329033, 0.014085750095546246, -0.00891511794179678, 0.001971937483176589, 0.001730303280055523, -0.010145255364477634, -0.018600760027766228, 0.02146657556295395, -9.858631528913975e-05, 0.008921876549720764, 0.0008279772009700537, -0.015410513617098331, -0.023548346012830734, -0.008354120887815952, 0.011997220106422901, 0.01762746460735798, -0.013038106262683868, 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92,Essential Oils and the Brain Module 2,1999.46,2151.3,"Tonight, we're going to discuss in module two, the blood brain barrier and how that works and how we know or what evidence do we have that essential oil molecules actually go across the blood brain barrier. Okay? So let's go ahead and get started. This is our essential oil group, Shedding Light on Essential Oils. Come join us, invite others. It's a public group, got about 30,000 members, wanted to keep growing and putting out more education about the science of essential oils. So invite others. If you haven't already, look at my frequently asked question database, which has over 70 articles and 300 pages of information in it now. And it just keeps growing. For one fee, you get access to the entire database plus all the updates as I make them. Seven module series, this is a good one to go through.",177,"[0.008183429017663002, 0.0018505407497286797, -0.01395685039460659, -0.04006966948509216, -0.02489457279443741, 0.019333019852638245, 0.007534580770879984, -0.01517509575933218, -0.03556745871901512, -0.005952186416834593, -0.009745960123836994, 0.017227573320269585, -0.010269011370837688, 0.00776631198823452, 0.0004266340401954949, 0.007090980652719736, 0.04187055304646492, -0.0026649110950529575, 0.005710523575544357, 0.017028946429491043, -0.009792306460440159, -0.010580193251371384, 0.004141371231526136, 0.008348951116204262, 0.015042677521705627, 0.00969961378723383, 0.03140953555703163, -0.0199818667024374, -0.019213842228055, -0.013109375722706318, -0.008130461908876896, 0.028019635006785393, -0.01634037308394909, 0.004707457963377237, 0.0014011473394930363, -0.007792795542627573, 0.0009426501928828657, -0.01840609312057495, 0.0010105144465342164, -0.009898240678012371, 0.014897017739713192, 0.024073582142591476, 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93,Essential Oils and the Brain Module 2,2164.02,2269.82,"So last time in module one, we looked at the different application methods and how that will change the emphasis of how the molecules work in your body, how they get to different parts of your organs and your tissues. And then of course, we're talking about the brain, so what are the factors that control how those molecules actually go through your bloodstream and then get into your brain? And you can go through three different routes, really. The topical application on your skin, you can breathe it in through your lungs and get into your bloodstream that way, or then ingest it and get to your bloodstream. And there was differences between each of those methods. And then we also discussed the fact that inhalation also involves another bio activity, which is the olfactory response, which basically modulates the activity of the limbic system, the olfactory system in the base of the brain. We'll talk more about that as we go through the series, but inhalation has an added benefit. Okay.",200,"[-0.004069993272423744, 0.02863484062254429, 0.003279703436419368, -0.017241492867469788, -0.028160665184259415, 0.00925297848880291, -0.012736840173602104, -0.03208577260375023, -0.03068959340453148, 0.0011648545041680336, -0.0038098562508821487, 0.002030057366937399, -0.015292110852897167, 0.02261546440422535, -0.00099115539342165, -0.006177433300763369, 0.0461265929043293, 0.0037604630924761295, -0.021495888009667397, -0.0017254664562642574, -0.002250680001452565, -0.010286941193044186, 0.01101137325167656, -0.006424399092793465, -0.0170307494699955, 0.01844009943306446, 0.02887192741036415, -0.027344033122062683, -0.011795077472925186, -0.020244594663381577, 0.005015048664063215, 0.015818970277905464, -0.01660926081240177, -4.1932704334612936e-05, -0.006213654763996601, 0.005792167037725449, -0.005015048664063215, -0.02232569083571434, -0.017715666443109512, -0.019111845642328262, 0.030083704739809036, 0.009602023288607597, 0.006842594128102064, -0.004995291121304035, 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94,Essential Oils and the Brain Module 2,2279.82,2413.9,"molecules and those receptors are activated and then send response to your limbic system in your brain. Very sensitive, very accurate. Our system is not as accurate or sensitive as a dog's or a rabbit's, but it is very accurate. Here's the olfactory bulb, the olfactory receptors, it's the base of the brain here. This is going to go to your cerebral cortex into your olfactory center in your brain, the limbic system. So this is pretty unique. We think that humans can distinguish about one trillion different odors based on all of the different combinations of those 350 different receptors that can be activated. So any one of those receptors can be activated or any combination of those 350 can be activated at one time and that pattern of activation, say that's number 17, number 23 and number 342, those three receptors let's say get activated by one molecule, that's going to send a very specific response to your brain as you perceive that odor.",202,"[-0.013020380400121212, 0.011041231453418732, -0.013796767219901085, -0.014331327751278877, -0.019066011533141136, 0.02139517106115818, -0.006341549102216959, -0.02358432486653328, -0.02998633123934269, 0.0010723040904849768, -0.01718232035636902, 0.01897691749036312, -0.04032117873430252, -0.006694741081446409, -0.016800491139292717, 0.01010574959218502, 0.041517578065395355, 0.011849436908960342, -0.016711397096514702, 0.01653321087360382, -0.01972784847021103, -0.012358542531728745, -0.0042446693405508995, -0.012237629853188992, 0.008362062275409698, 0.000322566251270473, 0.026448044925928116, -0.03563740476965904, -0.02240065485239029, 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95,Essential Oils and the Brain Module 2,2417.06,2515.94,"bloodstream. So they're complementary to each other, those two different responses. And here's the limbic system in your brain, basically here's the olfactory bulb and it's going to stimulate things like the hippocampus, the amygdala, the piriform complex, the hippocampus, all of those structures are in this area and they're all interconnected. These are involved with low level processes in the body, autonomic processes, things that control homeostasis in the body that maintain blood pressure, your emotions are connected here, your fear centers, your amygdala is involved with your fear centers, emotional memory, cognitive types of things. Also very important is the hypothalamus is part of this structure and that as you know is involved in the HPA axis, the HPG and the HPT axis, those three axis which we'll talk about more in this series.",180,"[-0.03477012738585472, 0.015100895427167416, 0.019783442839980125, -0.026267943903803825, -0.04091200605034828, 0.011243187822401524, 0.00725223682820797, -0.010526212863624096, -0.0010897390311583877, -0.011408155784010887, -0.014301436021924019, 0.00496806763112545, -0.011845954693853855, -0.0054883505217731, -0.0029392815195024014, -0.015113585628569126, 0.04522654786705971, -0.006738298572599888, -0.019199710339307785, 0.008749636821448803, 0.0037117747124284506, -0.019808821380138397, 0.0044319224543869495, -0.01364156510680914, 0.01107821986079216, 0.015913045033812523, 0.007404514588415623, -0.024910133332014084, -0.017829207703471184, -0.02082400768995285, -0.004485854413360357, -0.0028187280986458063, -0.01157312374562025, 0.0007026992389000952, 0.007537757977843285, 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96,Essential Oils and the Brain Module 2,2524.9,2639.46,"But the hypothalamus actually is like a master control, controls the pituitary and then that goes either to your adrenal axis or to your gonad axis or through your thyroid. So the HPT, the HPA, the APG axis is those three, we're all basically originating at the hypothalamus which is part of this limbic system and that's all hormonal type of response, your metabolism, when different sex hormones are released, etc., etc., growth hormones, stress hormones, all of that are basically being regulated by the hippocampus and that's connected to limbic system through the olfactory bulb. So unique odors can actually modulate how the hippocampus is functioning as well as the mygdala, the hypothalamus, etc., etc., these are involved in memories and all of that. Anemotions, heating, hunger, appetite, when you're full, when you're hungry, thirst, that's all being controlled through these centers as well.",200,"[-0.016552818939089775, 0.006386038847267628, 0.00846963282674551, -0.0355788990855217, -0.03199782222509384, 0.012450038455426693, 0.009184560738503933, -0.008102508261799812, 0.0031141198705881834, -0.01581856980919838, 0.004376513883471489, 0.013229373842477798, -0.01933523826301098, -0.005977049004286528, -0.008018777705729008, 0.0026407220866531134, 0.05363886430859566, 0.0003276749630458653, -0.011232730001211166, 0.01769927889108658, -0.004875674843788147, -0.021048488095402718, 0.009178119711577892, -0.007097745779901743, 0.01306835375726223, 0.008765908889472485, 0.003812944982200861, -0.0339042954146862, -0.007426226045936346, -0.012926656752824783, -0.002280038082972169, 0.0016681634588167071, -0.009835079312324524, 0.0019950333517044783, -0.004788724239915609, 0.003403955139219761, 0.007928607054054737, -0.012765636667609215, 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97,Essential Oils and the Brain Module 2,2644.78,2760.9,"to control your appetite. Responding to pain and pleasure, pleasure centers are here as well. Breathing, pulse, blood pressure so you can relieve stress and reduce the effects of stress by lowering blood pressure, things like that. So all of these really unique aspects of aromatherapy are all being driven through the olfactory system. Now, when you ingest oils, it's a little bit different story, right? So if you put it on your skin or you ingest the oil, when you ingest the oil, it's going to go through your liver, through the paddock cordal vein which we discussed last time, and then there's going to be metabolism in the liver that's going to chemically modify the essential oil molecules by derivatizing them with other functional groups and basically change the chemical structure of the essential oil molecule to make it more readily excretable in your urine and it's helping your body flush that out of your system, these molecules.",195,"[-0.009834649041295052, 0.015087694860994816, 0.008570758625864983, -0.03212388604879379, -0.017786627635359764, 0.017023026943206787, -0.01999843679368496, -0.037047795951366425, -0.023316148668527603, -0.0011626806808635592, 0.00038776593282818794, 0.015364171005785465, -0.022460389882326126, 0.010282277129590511, -0.02568594366312027, 0.0052168401889503, 0.059982143342494965, 0.013093117624521255, 0.006905319169163704, 0.0014432709431275725, 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98,Essential Oils and the Brain Module 2,2766.0,2875.4,"So there's a lot of factors there. What I'm saying is you can't assume that if you ingest an oil, you're going to get the same exact response as if you topically apply it or inhale it. And that's all summarized for you in this nice table, the different types of application, topical inhalation or ingestion, what organs you reach, the amount of dose that is delivered to your body, how much time it takes to be absorbed into your system through that different application method, if there's any chemical modification due to metabolism in the liver, as well as what are the advantages or unique aspects of that application method. So with inhalation, the unique aspect is twofold. One is you get absorption through the lungs into your bloodstream of those molecules and that gets into your systemic circulation. 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99,Essential Oils and the Brain Module 2,2886.74,3022.7,"So if you breathe in an oil, you're going to have molecules stimulating the olfactory response while those are molecules that are going through your bloodstream and also affecting receptors and other biochemical pathways and protein networks as those molecules travel through your bloodstream and then interact with the different molecules. So you're getting two different effects with inhalation. The downsides with inhalation is the dose that you receive is very low in your bloodstream. Now you don't need a high dose to stimulate olfactory response. Like I said, that's down in the parts per trillion levels. So as long as you have one molecule floating around in the air and it activates that receptor, which is very sensitive to that, it's going to give you that olfactory response. You don't need a lot high dose to stimulate the olfactory response.",165,"[-0.02150065079331398, 0.019883574917912483, 0.006051100790500641, -0.0035155245568603277, -0.024734804406762123, 0.016623547300696373, -0.0289780143648386, -0.03467012196779251, -0.04403623193502426, 0.003476714715361595, -0.0059799496084451675, 0.025368697941303253, -0.014010352082550526, 0.012380339205265045, -0.005313714034855366, 0.00041963139665313065, 0.04918500408530235, 0.0021280727814882994, 0.010342822410166264, -0.0009977363515645266, -0.0060381642542779446, -0.0035155245568603277, 0.00047461199574172497, 0.0017205695621669292, -0.0025420445017516613, 0.009366108104586601, 0.027141014114022255, -0.03761967271566391, -0.016364816576242447, -0.01285252533853054, 0.006940492894500494, 0.03720569983124733, -0.018783962354063988, 0.0011279109166935086, 0.002918823389336467, 0.011662356555461884, 0.0014658799627795815, -0.02593790926039219, -0.0018984479829668999, -0.016300132498145103, 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100,Essential Oils and the Brain Module 2,3036.14,3140.86,"So we discussed this just a few minutes ago. The olfactory versus systemic response. Systemic is what I'm referring to. When I say that, what I mean is gets into your bloodstream, the molecules get into your bloodstream, travel through your bloodstream into the tissues and cells of your body that way. The olfactory is interacting with the olfactory receptors in your nose. Completely different activity profiles. So now we're going to add some new material now. This is the blood brain barrier. So once you get molecules into your systemic circulation through topical or ingestion or inhalation it gets into your lungs and then into the capillaries of your lungs and into your bloodstream that way. The molecules are now in your bloodstream. Where do they go? They go to all tissues of the body.",160,"[-0.016205618157982826, 0.014712659642100334, -0.0014028387377038598, 0.0033113055396825075, -0.019510542973876, 0.006188759580254555, -0.0013111238367855549, -0.029501881450414658, -0.043589286506175995, 0.011988329701125622, 0.0015782932750880718, 0.008600462228059769, -0.00800072681158781, 0.0064822472631931305, -0.004775553476065397, -0.01607801578938961, 0.05298088863492012, 0.00988287478685379, -0.02435946837067604, -0.0031597765628248453, -0.01389599870890379, -0.017736857756972313, 0.0006475867121480405, -0.009359701536595821, 0.0030991649255156517, 0.021781882271170616, 0.02280270867049694, -0.03720911964774132, -0.01958710514008999, -0.007732759695500135, -0.02271338552236557, 0.023734211921691895, -0.024882642552256584, -0.008058148436248302, 0.010986643843352795, -0.006999040488153696, -3.7321472063922556e-06, -0.021590476855635643, -0.02262406423687935, -0.0044661154970526695, 0.008236792869865894, 0.013130378909409046, 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101,Essential Oils and the Brain Module 2,3147.7,3283.98,"So it's very selective. So there's a big debate in the essential oil community. Do essential oil molecules get into the brain? We know they stimulate the olfactory response. That's not the same thing as saying that the molecules get into your bloodstream, travel directly into your brain tissue and interact in the cells of your brain. You see the difference of what those two things are. So what we're going to talk about tonight in module two is what evidence do we have to assume that these molecules are getting into the brain? Okay? Because that's very important to know. We don't want to assume that they are and if they're not and we don't want to assume that they're not if they are, right? So we want to know. So what do we have? There's a big debate and you'll find different opinions of this as you search on the internet. Some people say no, they don't get in the brain. 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102,Essential Oils and the Brain Module 2,3295.5,3411.14,"So metabolically speaking, those molecules are leaving the body pretty fast. So any molecules that get into the brain after you stop taking the essential oil, they're going to leave. So you're not going to be able to do an autopsy on somebody that's randomly died to see if they have essential oil molecules in their brain. The chances of that happening are very slim. And so we just don't have clinical data to be able to take tissue samples of somebody's brain and figure out if there's essential oil molecules in there, right, after you take them. So we have to use indirect evidence, which we'll talk about. We can do it in animals, of course, and we'll show you some of that data. So what is the blood brain barrier? So it's semi-permeable, meaning let certain things through and other things not. 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103,Essential Oils and the Brain Module 2,3418.88,3533.34,"of randomly diffuse through on their own accord through the membrane. Then there's other type of transport where it's very active and proactive, meaning the molecule binds to a receptor, the receptor grabs the molecule, pulls it in, and then pushes it through the barrier. That's a receptor-mediated process where the molecule moves through that way. There are certain molecules that go through like glucose. Glucose when you take sugar gets through your bloodstream to get into your brain and actually specific receptor called the GLUT1 receptor that grabs glucose and lets it into the cell. Other things just kind of diffuse through if they can make it through the barrier. There are parts of the brain that are not protected by the blood-brain barrier. Those tend to be the sensory organs of the brain, which these are all part of what they call the circumventricular organs of the brain.",173,"[-0.010851482860744, 0.0056196353398263454, -0.002895262325182557, -0.006654831115156412, -0.00471917912364006, 0.022425958886742592, 0.003391499165445566, -0.009517230093479156, -0.04900584742426872, -0.008445884101092815, 0.009773564524948597, 0.012001700699329376, -0.014433588832616806, 0.0074534108862280846, -0.016050467267632484, -0.006720557808876038, 0.038121502846479416, 0.0189687330275774, -0.034966617822647095, -0.012435496784746647, -0.00935291312634945, -0.005314006004482508, 0.003660978749394417, -0.008255276829004288, -0.014512461610138416, 0.028236201032996178, 0.03402015194296837, -0.03139108419418335, -0.01602417603135109, -0.016103047877550125, 0.0019849471282213926, 0.025488823652267456, -0.03052349202334881, 0.01367115881294012, 0.013855193741619587, 0.010108770802617073, 0.0005118468543514609, -0.002418743446469307, 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104,Essential Oils and the Brain Module 2'Essential Oils and the Brain Module 1,0.0,3600.46,"to be able to detect and measure what's in the blood. You don't want the blood totally separated from those unique detection systems that are in the brain. Those sensory organs are not really part of the blood-brain barrier system. They have direct access. The other type of structures in the brain that are not connected through the blood-brain barrier, not protected, are secretory organs. They secrete something, usually a hormone, like the pituitary gland. The pituitary gland at the base of the brain is going to be able to secrete a hormone into your bloodstream because of the HPA axis or the HPT or the HPG axis. That's a neuroendocrine or hormone response where those hormones have to be secreted by the cells in the pituitary gland go directly into the bloodstream. 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105,Essential Oils and the Brain Module 1,128.36,233.94,"Let's just call them protective areas of the brain, and then we'll talk about what they are. You have four different ones, which we'll look at. Here you see it zooming into this area of the brain. This is just basically brain tissue somewhere in the middle of your brain. You have capillaries, which is shown here. These little micro blood vessels that are flowing through the blood is flowing here. Then this yellow area is the brain tissue itself. You see the endothelial cells, which are these white rectangles that line the capillary. These cells are basically connected together to protect the passage of molecules and block molecules from getting into the brain. That's part of the blood-brain barrier of these endothelial white cells here. Then there's other cells like these purple ones, which are called parasites. Then you have these blue ones, which are called astrocytes. 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106,Essential Oils and the Brain Module 1,244.8,343.92,"CPEC. These cells here block the passage of molecules between the cerebral spinal fluid and the blood vessel. There's another barrier. Then down here, you have a region right here on the outside portion of the brain where the PIA layer, the Pyridora layer on the outside. You have the arachnoid space there as well. You have cerebral spinal fluid there, and you have the brain, and you have blood vessels all together in one area in this section here. The blood-brain barrier here is actually keeping molecules from flowing from the brain to the blood vessel, and the blood vessel to the cerebral spinal fluid, and from the cerebral spinal fluid this way. It's protecting these three different fluids, basically, or tissues from molecules flowing back and forth. If you have essential oil molecules flowing through your bloodstream here, they're not going to get into the CSF of the brain unless they have a way to get through there, which we're going to talk about.",199,"[0.006709304638206959, 0.019643062725663185, 0.018883023411035538, -0.024347437545657158, -0.014846958220005035, 0.005097499117255211, 0.010476736351847649, -0.027466217055916786, -0.014217960648238659, -0.01909269019961357, 0.006568435579538345, 0.010168789885938168, 0.005746152717620134, 0.005235092248767614, -0.005778912920504808, 0.0022080426570028067, 0.033022359013557434, 0.005068014841526747, -0.022342508658766747, 0.013720003888010979, -0.01061432994902134, 0.018725775182247162, -0.002186748431995511, 0.00468799564987421, -0.003963993396610022, 0.030689828097820282, 0.016484972089529037, -0.02459641732275486, -0.0191844180226326, -0.017952632158994675, -0.0024471927899867296, 0.019249938428401947, -0.008688025176525116, 0.00200656708329916, -0.0017969012260437012, 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107,Essential Oils and the Brain Module 1,346.04,455.76,"You have the endothelial cells, and you have the astrocytes, which I explained earlier as these blue guys. Remember? Astrocytes. These are basically these white ones that are wrapping around. These are the astrocytes that wrap around the blood vessels to form that protective barrier. Here's a schematic of what it looks like. We're going to talk about essential oils and how they get through this barrier now. Essential oils are small. We talked about that in the first module. They're also lipophilic, which we're going to talk about here in a second. Lipophilic means that they like to dissolve and interact with other fatty lipid molecules. Here's the blood-brain barrier. Here's blood on this side flowing through a vessel, and here's the brain tissue itself. These are the endothelial cells, these purple guys, or the individual cells lining the blood vessel.",183,"[0.0005461900145746768, 0.00854669138789177, -0.013169471174478531, -0.026621052995324135, -0.034366291016340256, 0.014977548271417618, 0.0039399415254592896, 0.0013256027596071362, -0.007943999022245407, -0.006995079107582569, 0.00027850482729263604, 0.005494759883731604, -0.00827099196612835, 0.006687321234494448, -0.01985038071870804, 0.005337675102055073, 0.046497080475091934, 0.010495824739336967, -0.03023720718920231, 0.01726008579134941, -0.02483862265944481, 0.012470603920519352, -0.004920919891446829, 0.006834788713604212, 0.005901897791773081, 0.02146610990166664, 0.018503939732909203, -0.02146610990166664, -0.012727068737149239, -0.03682835400104523, -0.005533229559659958, 0.016195757314562798, -0.004606750328093767, -0.007533655501902103, 0.0052575296722352505, -0.00409702630713582, 0.014195330440998077, -0.014451795257627964, 0.025723425671458244, 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108,Essential Oils and the Brain Module 1,460.96,565.2,"I want to make sure my connection is good. Okay. I'd like to hear from you. Okay. Good. Good, good, good. So essential oil molecules are small. Here's the different ways things can get through the blood-brain barrier. Remember, some things have to get through, so we have mechanisms in place for that to happen. Okay. So like water has to get through. Oxygen, O2, carbon dioxide, okay, those are basically going to get small and they get through pretty easily. So you have these small molecules that diffuse through. Now you have other things that are like small steroid or hormone-like molecules that are lipid soluble, that are small, that can go through the membrane of the cell, which is a lipid, a phospholipid, and basically absorb into that and permeate through the membrane of the cell, get into the cell, and then leave out the other membrane of the cell this way.",193,"[-0.003847874701023102, 0.022495267912745476, -0.0017873264150694013, -0.021103138104081154, -0.01915155164897442, 0.02172764390707016, 0.003948706667870283, -0.016536429524421692, -0.020725831389427185, -0.008411331102252007, 0.0076306965202093124, 0.023991482332348824, -0.014832044951617718, 0.024043524637818336, -0.006967158056795597, 0.019229615107178688, 0.04475634545087814, 0.019919175654649734, 0.0023809336125850677, 0.007214358542114496, 0.006323134992271662, -0.0016401443863287568, 0.00779332872480154, -0.0051359208300709724, 0.007715265266597271, 0.014415706507861614, 0.036325499415397644, -0.02734820917248726, 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109,Essential Oils and the Brain Module 1,575.08,665.96,"Then there's proteins in the membrane, receptor proteins, that specifically recognize molecules that should get through and can bind to them and then let them into the cell and then if they need to get through all the way, then actually secrete them on the other side of the cell. So like glucose, which I already described, glucose can bind to the Glut1 receptor, which recognize glucose, lets it transport through, then another Glut1 receptor lets it secrete out on the other side. So it's very specific, it's like a gateway or a door that specifically opens for glucose, but nothing else. Okay. Then there's a third process, which we call transcytosis, which is also like a receptor.",148,"[-0.016285549849271774, -0.002367815701290965, 0.004220098722726107, -0.011454081162810326, 0.0044844746589660645, 0.01713155210018158, -0.010647735558450222, -0.011758113279938698, -0.03933911770582199, 0.009795122779905796, 0.022749537602066994, 0.015320577658712864, -0.022511599585413933, 0.012392614968121052, -0.005489102564752102, -0.005039663519710302, 0.031963035464286804, -0.000406684324843809, -0.02675483003258705, -0.006592871621251106, -0.02249838039278984, -0.008327837102115154, 0.005360219161957502, -0.026199640706181526, -0.009742247872054577, 0.008995386771857738, 0.02860546112060547, -0.035056229680776596, -0.015955079346895218, -0.024150729179382324, -0.005789829883724451, 0.02044946700334549, -0.040819622576236725, 0.014302730560302734, 0.0060839480720460415, 0.015399890020489693, -0.006034377496689558, 0.008030414581298828, 0.007713163737207651, 0.0009269676520489156, 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110,Essential Oils and the Brain Module 1,676.0,780.6,"Let's discuss that. So when drug companies make drugs and they want the drug to get into the brain, they design drugs that have a specific molecular weight size, usually less than 500 atomic mass units. It has to be smaller than 500 atomic mass units, which we call AMUs. And they want to get the polarity, which is a measure of the molecule's lipid-like characteristics or water-loving characteristics. So they're trying to distinguish if the molecule loves to interact with oil and lipids more or interact more with water. So you can mathematically quantify that with a value called log P. So log P is a scale that determines how polar or non-polar a molecule is. If it's polar, it likes to interact with water more. 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111,Essential Oils and the Brain Module 1,787.76,873.2,"So they know that molecules that have a log P value somewhere in the range of 2 up to 6 can go through this diffusion-based pathway where the molecule goes through. If it's less in size than 500 and it has a log P value between 2 and 6, it can get through. Now essential oil molecules have AMUs in the range of 100 up to 500. So essential oil molecules are small and they vary in size anywhere from 100 atomic mass units up to 500, whether it's a monoturpene or a diterpene or a sesquiterpene or a triterpene. Those molecules are just different sizes, but even the largest molecular weight essential oil molecules are basically going to be no more than 500 atomic mass units. So those essential oil molecules are small enough to do this diffusion thing, and their log P values tend to be somewhere in the range of 2 to 6.",195,"[0.012492718175053596, 0.01133634615689516, -0.009023601189255714, -0.042071159929037094, -0.02777891978621483, 0.03432736545801163, -0.009367914870381355, -0.00870527420192957, -0.02542719617486, -0.014240269549190998, 0.0012050957884639502, 0.02757103182375431, -0.0143052339553833, 0.011037508025765419, -0.01731959730386734, 0.044643763452768326, 0.03128701448440552, 0.008581841364502907, 0.003862153273075819, 0.009770696051418781, -0.006632899399846792, -0.012265341356396675, -0.024049943313002586, 0.004758666735142469, 0.013941431418061256, 0.037549614906311035, 0.03230046480894089, -0.01824209652841091, -0.019970158115029335, -0.013928438536822796, 0.01365558709949255, 0.031183071434497833, -0.039576515555381775, 0.005690910387784243, 0.0031475413125008345, 0.01955438405275345, 0.013889459893107414, -0.012232859618961811, 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112,Essential Oils and the Brain Module 1,879.44,986.08,"What does that mean? That means there's going to be some essential oil molecules that are greater than 3 in the log P scale that probably won't go through the blood-brain barrier, but the ones that are 2 to 3 in this range are going to have no problem getting through. Now this is not a rigid black and white rule. These are just general rules of thumb. There's exceptions to this rule. So there's probably molecules that are 4, 5, or 6 that can still get through. It's going to depend on their shape and their concentration and other factors. But this is just a general rule of thumb. So what we can probably conclude from this is that a lot of the essential oil molecules are going to get through or have the capacity to get through, and some of them will not have the capacity. Now the ones that probably won't get through are the ones that are more polar or the ones that like water more.",198,"[0.0222238190472126, 0.012879861518740654, 0.00961897149682045, -0.021503541618585587, -0.009605875238776207, 0.01967010833323002, 0.00032269227085635066, -0.010162453167140484, -0.032975587993860245, -0.00242602382786572, 0.013580494560301304, 0.018792681396007538, -0.02831343188881874, 0.004023728892207146, -0.00900346226990223, 0.030696894973516464, 0.037925854325294495, 0.007634935900568962, 0.0028303610160946846, 0.009075489826500416, 0.0004825037030968815, 0.003565371036529541, -0.005248199682682753, -0.0016893768915906549, -0.00810639001429081, 0.029963521286845207, 0.03533285856246948, -0.010777962394058704, -0.011603007093071938, -0.023585796356201172, 0.030932622030377388, 0.03386611491441727, -0.039864055812358856, 0.005660722032189369, 0.01082379836589098, 0.011072621680796146, 0.014890089631080627, -0.003565371036529541, 0.004419881384819746, 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113,Essential Oils and the Brain Module 1,992.88,1120.56,"OH group or an aldehyde or an ester or a carboxylic acid basically going to be attached. There's different ways you can get oxygen chemically attached to a molecule. Now essential oils, they have these oxygenated terpenes or terpenoids, but they also have the terpene form that doesn't have the oxygen attached. And also when you leave an essential oil out in a bottle and the air interacts with it, oxygen, you shake it, or ultraviolet light interacts with it with oxygen, that photochemical reaction will cause oxygen to oxygenate and oxidize these molecules and they will become more and more polar and less and less lipid-like and their log p-values will go up and then they will have a harder time getting through the blood-brain barrier.",160,"[0.009194979444146156, 0.011433360166847706, -0.0067999777384102345, -0.042209457606077194, -0.01696731522679329, 0.01425254438072443, 0.003540295409038663, 0.0012358404928818345, -0.013521644286811352, -0.005292497109621763, -0.006180018186569214, 0.03610122576355934, -0.03351697325706482, 0.025855576619505882, -0.010637201368808746, 0.01243834663182497, 0.03824171796441078, 0.02753925696015358, 0.02701718546450138, 0.005031461361795664, -0.018716253340244293, 0.0065063126385211945, -0.015335842035710812, 0.005912456661462784, 0.01510091032832861, 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114,Essential Oils and the Brain Module 1,1129.0,1220.16,"So oils that are old have been stored for a long time in high temperature or light conditions, exposed to UV light, or if the essential oil manufacturer itself overexposed the oils to temperature when they were distilling them, or if they're old oils, they just got an old batch from somebody that's really expired because they don't care about quality, then they're going to have a large percentage of the molecules that are oxygenated and those molecules are oxidized. Those molecules are going to be less and less able to cross over to the blood-brain barrier. So some of the molecules in essential oils, native molecules that have not been oxidized, do have oxygen in them. You can see some of those here and that's going to affect the log p-value.",157,"[0.018641361966729164, -0.014494392089545727, -0.003200233681127429, -0.03104226663708687, -0.02702864073216915, 0.01833467185497284, 0.003776942379772663, -0.01828133501112461, -0.024441784247756004, 0.0041102999821305275, 0.002255164785310626, 0.0363759882748127, 0.00036794354673475027, 0.010934132151305676, -0.01926807314157486, 0.022108281031250954, 0.03200233727693558, 0.019201401621103287, 0.014494392089545727, 0.008660632185637951, -0.020454827696084976, 0.008260603062808514, -0.014174368232488632, -0.005313721485435963, 0.011887534521520138, 0.0035902622621506453, 0.018294669687747955, -0.029255470260977745, -0.009160668589174747, -0.01676122471690178, 0.014961092732846737, 0.03125561401247978, -0.043016474694013596, -0.0033635790459811687, -0.01080078911036253, -0.011154147796332836, -0.00937401782721281, -0.012374237179756165, 0.011514173820614815, -0.02302834764122963, 0.012760931625962257, 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115,Essential Oils and the Brain Module 1,1227.92,1303.6,"You're going to have molecules that go through and other ones that don't. So we're still good? So that's one piece of evidence that we have is that they have the right log p-value, the right size. These are the log p-values and size characteristics that drug companies design into molecules to make them drugable to the brain. So the pharmacokinetics work out to get to the brain. So these molecules already have those characteristics to do that. So the second piece of evidence is that we've done experiments with animals, I would say limited experiments with animals, that show, and again you can go to the brain and get slices of the tissue and measure the concentration of the molecule in the brain. So I'll give you an example in this slide here. They did a study on mice and they looked at this molecule here, elamine, which is a sesquiterpene. 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116,Essential Oils and the Brain Module 1,1311.76,1405.4,"After two hours, 120 minutes, it was up to six, it kind of peaked there at two hours and then started coming down. Again, your body is metabolizing and going to secrete it out of the urine. So you can see this molecule made its way into the brain of the rat and the blood-brain barrier of the rat tends to be a good model for modeling, understanding, correlating what's going to happen in the human blood-brain barrier. So elamine is a prototypical molecule meaning that it's suitable to mimic what other terpene molecules may be doing when they enter into the bloodstream. So you can kind of make some indirect correlations between this molecule and other molecules that are found in essential oils.",149,"[-0.0022810494992882013, 0.0003130685072392225, -0.01261828187853098, -0.027679692953824997, -0.005432207603007555, 0.004643991589546204, 0.0049101426266133785, -0.0158325657248497, -0.03750680014491081, -0.015791619196534157, -0.019476784393191338, 0.01723838783800602, -0.0031119179911911488, 0.012277062982320786, -0.01822109892964363, 0.007117830216884613, 0.038325726985931396, 0.0029549573082476854, -0.021537749096751213, 0.023735199123620987, -0.022343026474118233, -0.019736111164093018, 0.00025634083431214094, 0.006933571770787239, -0.006926747504621744, 0.023844389244914055, 0.01345768105238676, -0.026110084727406502, -0.011976789683103561, -0.014126470312476158, -0.0014996578684076667, 0.01222929172217846, -0.0316651314496994, 0.00047258843551389873, 0.00494426442310214, 0.013942211866378784, 0.015600536949932575, 0.017402173951268196, 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117,Essential Oils and the Brain Module 1,1413.76,1499.7,"Now this is looking at intravenously giving the molecule to the mice and you can see that in 20 minutes the concentration went up to 15, three times higher, so that it went in much faster to the brain, which is what you would expect because this was gastric and this was intravenous. And then you can see again it just falls off over time as the body metabolizes it. So in both cases getting into the brain that's being metabolized out of the brain, it's not residing there, staying there, eventually your body is going to rid those molecules out of your body. So you're not going to hang around. And that molecule there is sort of a mid-range size molecule in terms of essential oil molecules we concern. It's probably pretty low on the log P scale because there's no oxygen groups attached to it so it's pretty non-polar, lipophilic, lipid loving.",186,"[-0.004195455927401781, 0.02183227613568306, 0.005878940224647522, -0.023316925391554832, -0.012201949022710323, 0.007602192461490631, -0.00902056135237217, -0.02786365896463394, -0.0402180477976799, 0.0039336541667580605, 0.00754254125058651, 0.022680647671222687, -0.003246010048314929, 0.0136269461363554, -0.008669283241033554, 0.020612744614481926, 0.04358501732349396, 0.0007481233333237469, 0.007005681749433279, -0.003545922227203846, -0.007012309972196817, 0.0017249089432880282, 0.002014879137277603, -0.0006408343324437737, 0.014130665920674801, 0.030938999727368355, 0.011631950736045837, -0.021553905680775642, -0.013772759586572647, -0.014713920652866364, 0.01294427365064621, 0.015628568828105927, -0.013461248949170113, 0.014117410406470299, 0.009080212563276291, 0.007184634916484356, 0.008874747902154922, -0.024881107732653618, 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118,Essential Oils and the Brain Module 1,1508.04,1608.36,"Again you're not going to do that in a human unless you want a really large lawsuit or go to jail. So the third reason we feel like essential oil molecules go through the blood-brain barrier is that when you ingest certain essential oils they have the same effect as they do when you inhale them. So to give you an example, so if you ingest it, it's going through the systemic, when you inhale it's mostly the olfactory response. Again remember I said you don't get a huge concentration of the molecule when you inhale it into your lungs even though it's probably one one hundredth of what you would get in your bloodstream if you were applying it topically or ingesting it. So to give you an example, salvia aficionalis sage, right? So moss, and I gave you the papers down here so you can go look up these papers. Here's the reference right down here. 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119,Essential Oils and the Brain Module 1,1621.56,1736.92,"So again, what I said earlier about ingesting the oils and it goes through your liver and then it gets, some of the molecules get chemically altered. Some of those molecules may not get through the brain at that point and it's going to depend on species and composition and all of that. So what I'm saying is you can't necessarily assume that if you get a certain response topically or through inhalation, you're going to get the same exact response through ingestion. You may, like in this example they did, but in this example they did not. And I will also say there's not a ton of data on every single essential oil showing you the differences between the different application methods and what the direct correlation is with different types of physiological responses. So a lot of the data that we have, you have to piece it together through anecdotal data, through testimonials, through stories, through experimentation on yourself.",186,"[0.0022856486029922962, 0.01707485131919384, 0.007262017577886581, -0.030063191428780556, -0.03615391626954079, -0.0009573695133440197, -0.00490316329523921, -0.016749491915106773, -0.024831416085362434, 0.0038880426436662674, -0.0016056477325037122, 0.019755812361836433, -0.016554277390241623, 0.006510437931865454, -0.008231588639318943, 0.015539156273007393, 0.0526561364531517, 0.004574550781399012, 0.004385842476040125, 0.009578575380146503, -0.01326814852654934, -0.0036570376250892878, -0.0006734936032444239, -0.006676371209323406, -0.008120966143906116, 0.013469872064888477, 0.026158880442380905, -0.0323537215590477, -0.0296207033097744, -0.01195369753986597, 0.004031200893223286, 0.029048070311546326, -0.016424132511019707, -0.007105845492333174, 0.003338185604661703, -0.018142029643058777, 0.004912924021482468, 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120,Essential Oils and the Brain Module 1,1745.92,1856.32,"also correlated with the concentration of 1-8-cineol in the plasma in your blood. So if the concentration of 1-8-cineol went up in the bloodstream itself, which is separate from the olfactory response, then they would see an increase in the locomotor activity which is being controlled through the brain. So they know that since it's correlating with the concentration in the blood itself and the activity has to take place in the brain, that it has to be getting from the blood to the brain. So again, this is indirect evidence. The fourth piece of evidence. The molecules themselves, certain molecules in essential oils have been shown to interact with and bind to enzymes that are present in central nervous system tissue and interact with those enzymes.",154,"[0.006690698210150003, -0.005219204351305962, 0.007120978552848101, -0.04690386354923248, -0.008579334244132042, 0.010412132367491722, -0.004483457654714584, -0.01543754618614912, -0.03552606329321861, -0.007180101238191128, -0.0021990290842950344, 0.029876578599214554, -0.020614050328731537, 0.015030257403850555, -0.032346587628126144, 0.020758572965860367, 0.05192270874977112, 0.01078000571578741, -0.004729801323264837, 0.02738029509782791, -0.025632895529270172, 0.002650659531354904, -0.013079214841127396, -0.018669577315449715, 0.009577848017215729, 0.02025931514799595, 0.019024312496185303, -0.053972288966178894, -0.010077104903757572, -0.02735401876270771, 0.0033437067177146673, 0.021192137151956558, -0.022886984050273895, -0.00018763187108561397, -0.0011931252665817738, 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121,Essential Oils and the Brain Module 1,1869.94,1977.68,"pathway. So with dementia and with Alzheimer's, acetylcholine decreases and is depressed. And so one way to get those levels back up is to inhibit this enzyme which breaks it down. So a lot of the drugs for dementia and Alzheimer's is to block this enzyme here. They found that certain constituents within rosemary, they looked at rosemary, maronic acid, ursolic acid, and 1-ate-cineol, those three, those all can inhibit acetylcholinesterase in the test tube. But these essential oils also have the activity of increasing the locomotor and increasing cognitive capacity, speed, accuracy of doing math equations and all of that. So they think that that correlates with what they see in the test tube, which is it blocks these enzymes. 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122,Essential Oils and the Brain Module 1,1983.44,2098.88,"This one is in vitro inhibition of human erythrocyte acetylcholinesterase by Salvia, Lavendale folia, essential oil and constituent terpenes. Again, these are acetylcholinesterase inhibitors. Salvia for dementia therapy review of pharmacological activity and pilot tolerability clinical trial. Okay, so there's that for dementia. And then the synergistic and antagonistic interactions of acetylcholinesterase and terpenoids and Salvia, Lavendale folia, essential oil. So this is kind of key here, this reference. So if you take my class on synergy, you'll learn that one of the benefits of essential oils is that you have more than one molecule doing things in the body at the same time. 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123,Essential Oils and the Brain Module 1,2109.4,2213.52,"And so looking at what these different molecules can do in an essential oil as a team, what are they doing collectively as a network as they go into the brain and they start to work? So some of this data they're piecing together is through individual constituents. But then what happens when you start looking at combinations of these different constituents and different ratios? And so this paper here starts to look at that question. And there's antagonism that happens, which means they're fighting against each other, but there's also synergy. Now the synergy and the antagonism is going to be governed by the purification, the distillation, the growth of the plant and the species of plant, the type of soil that's grown in, how they harvest it, how they distill it, how time, temperature, pressure of the distillation. Those are going to change the ratio and composition of each of the individual constituents.",184,"[-0.0035074828192591667, 0.0050036124885082245, 0.003408401273190975, -0.05160161107778549, -0.03236659988760948, 0.026963360607624054, 0.011130147613584995, 0.004792238585650921, -0.033872637897729874, -0.03545794263482094, 0.002217772649601102, 0.03405759111046791, -0.008369077928364277, 0.021599752828478813, 0.0004937557969242334, 0.0180856641381979, 0.051892250776290894, 0.005069666542112827, 0.0026950149331241846, 0.009181546047329903, -0.011790690012276173, 0.0041085765697062016, -0.0044388482347130775, -0.003045102581381798, 0.005746723152697086, 0.037360306829214096, 0.025866858661174774, -0.03775663301348686, -0.015271751210093498, -0.007853854447603226, 0.005363608244806528, 0.019750231876969337, -0.01215398870408535, 0.004273712635040283, -0.0105224484577775, -0.019340695813298225, -0.0004508205165620893, -0.0028469397220760584, -0.0013293426018208265, -0.007351842243224382, 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124,Essential Oils and the Brain Module 1,2222.2,2312.68,"profile when you use it. And then you use one from another company and it doesn't give you the same result. And maybe it's a reputable company in terms of having, they're not adulterating it, they're doing something mischievous like that, but they just don't have the same characteristics in terms of the ratio of the different components. And so you notice that there's a completely different activity when you use that one oil. That's why I think it's important once you have an oil you know works for you for a given thing, to stay with that oil, with that company and to use that one because synergies and antagonisms are really sensitive to small changes in composition of the oil. And that can happen when you start jumping around from different companies or whatever. So that was the fourth, the in vitro data on the enzymes. 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125,Essential Oils and the Brain Module 1,2315.72,2402.68,"And then they looked at correlation between concentrations of 1-8-cineol in their blood stream and the factors they were measuring, which was how accurate were they, how fast were they when they did these mathematical operations and visual information processing tests. Now the results were that it says here we show for the first time that performance on cognitive tests is significantly related to the concentration of absorbed 1-8-cineol following exposure to rosemary with improved performance at higher concentrations. Furthermore, these effects were found for speed and accuracy outcomes indicating that the relationship is not describing a speed accuracy tradeoff. There's been other studies show that if you can do something through aroma therapy to increase speed of you know you're faster, then you're going to lose accuracy. 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126,Essential Oils and the Brain Module 1,2416.44,2513.92,"and citrus oils and we're going to discuss what we know about anxiety, depression, and some other mental factors and then we're going to get into specific data on that. So now that you have a good basis of how these things work, the rest of the information is going to make a whole lot more sense to you. So hopefully this information is useful. I'll put the slides and everything in the next couple of days into the link as well as the video for this and this video will be left up in this group here as well. So again, just a couple of things. You can get 30% off tonight of any of my classes or resources at StarfishSense.com, the frequently asked question database if you don't have it or module series or any of the other classes. So I'll take advantage of that if you want tonight. So see you guys next week. Thanks for coming. Hopefully the information was useful to you and I'll see you next weekend.",199,"[0.0064348746091127396, 0.008062239736318588, 0.015799006447196007, -0.046813882887363434, -0.024220623075962067, 0.014320816844701767, -0.00511942058801651, -0.014971762895584106, -0.011194918304681778, -0.02724481001496315, -0.01699240878224373, 0.041063856333494186, 0.005265205632895231, 0.033144012093544006, 0.001901983399875462, -0.00421080831438303, 0.04477967321872711, -0.014551360160112381, 0.013405423611402512, -0.019460579380393028, 0.011086427606642246, 0.008441958576440811, 0.003464932320639491, -0.008001213893294334, 0.004719359800219536, 0.002286787610501051, 0.012937556020915508, -0.009452281519770622, -0.022864485159516335, -0.02625483088195324, 0.0247495174407959, -0.006672198418527842, 0.0034751035273075104, -0.022254223003983498, -0.007852038368582726, -0.003415772458538413, 0.011791619472205639, 0.017778968438506126, 0.004278615117073059, -0.01122882217168808, 0.00027482982841320336, 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127,Essential Oils and the Brain Module 1,2522.04,2605.16,"We're gonna get started with the class. Jump right in. My name is Doug Corrigan. I am going to teach a new series starting tonight called Essential Oils and the Brain. So I've done a lot of different class series on essential oils and the science behind them. This is probably my 12th different class that I've offered, that I've put on. So this is a new series for me. I haven't taught this before, so it should be interesting. And love to hear all your questions and your feedback in terms of what you're learning, what other things you'd like to learn. I think this series will probably take about four different sessions. That's what I'm thinking, most of my series that I do like this usually take four or five different sessions, modules we call them, to get through all the material. So I'm thinking about four here. So this will go once a week on a Sunday night.",195,"[-0.007870247587561607, 0.005070763640105724, -0.01168652530759573, -0.04191302880644798, -0.0026014072354882956, -0.0023108948953449726, 0.0037667586002498865, -0.011429025791585445, -0.0237427931278944, -0.0016316567780449986, -0.015370751731097698, 0.02317497320473194, -5.728878477384569e-06, 0.017747672274708748, -0.014274727553129196, -0.0012305515119805932, 0.03496713936328888, 0.011079089716076851, -0.008081529289484024, -0.006183294113725424, -0.02000574581325054, -0.0008343980880454183, 0.016625236719846725, 0.011435627937316895, 0.009203963913023472, 0.003439931897446513, 0.0055296411737799644, -0.007579735014587641, -0.011488448828458786, -0.016691263765096664, 0.007355248089879751, 0.036630984395742416, 0.014868956990540028, -0.01608382724225521, -0.004994833841919899, -0.022725999355316162, 0.012815562076866627, 0.009626527316868305, 0.005503230728209019, -0.010993256233632565, 0.01614985242486, -0.0004048192349728197, 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128,Essential Oils and the Brain Module 1,2613.54,2710.92,"So if you didn't get that email, check your junk in your spam folder. If you still don't see it, private message me on Facebook and say, hey, I didn't get the email and give me your email address and then I will send it to you. That way you can have the slides and everything else. So just private message me on Facebook and I'll get that fixed for you if you didn't get it. So this is our Facebook group, Shedding Light on Essential Oils. That's my beautiful wife, Amy, and we've been doing this for about 18 months now. We have about 30,000 members in the group now and it's an open public group. The purpose of the group is to teach others about the science of essential oils. I have other resources for you. If you go to StarfishSense.com, some of you may be new and haven't seen my other materials. I have lots of different classes.",198,"[-0.023309675976634026, 0.002297536935657263, -0.011110770516097546, -0.03290623426437378, -0.017265941947698593, 0.0013683618744835258, -0.011936704628169537, -0.014578379690647125, 0.006171558052301407, 0.004726174287497997, -0.003955958876758814, 0.007505505811423063, -0.0038314133416861296, 0.02079254575073719, -9.340913675259799e-05, 0.013595125637948513, 0.03699657320976257, -0.008842731826007366, 0.001796077354811132, 0.00715153431519866, -0.019442209973931313, -0.010684694163501263, -0.0046737343072891235, 0.014853691682219505, -0.0008783736266195774, 0.008069238625466824, 0.02309991605579853, 0.002312285825610161, -0.01733149215579033, -0.0170037392526865, -0.0008361756335943937, 0.028894558548927307, -0.007262969855219126, -0.009557229466736317, -0.028081735596060753, -0.0015453476225957274, 0.0028711019549518824, -0.01177938375622034, 0.025027092546224594, -0.018694937229156494, 0.009557229466736317, 0.026180777698755264, 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129,Essential Oils and the Brain Module 1,2726.28,2828.0,"It's only like 60 pages long, but it really gives you a good understanding of the fundamentals of the chemistry, why that's important. You can give it out to people that you're trying to maybe recruit into young living. You want them to understand why the quality of the oil is important and how the oils work. This is a great oil book to get into their hands. I have a good special going on where you can get 30% off if you order two or more classes. You get 30% off your entire order today at StarfishSense.com, so if you want to do that. All right, so let's get started. This is module one. This is going to be all about the brain. The brain is essential command control center of the entire body. Most people don't recognize or realize that the brain is actually in control of more things than you realize.",182,"[0.005171211902052164, 0.012619100511074066, -0.0030422843992710114, -0.043814267963171005, -0.02719923108816147, 0.002585605951026082, 0.0026477277278900146, -0.01905960962176323, -0.02424425259232521, -0.02155791036784649, -0.01631953939795494, 0.03078550100326538, -0.013089210726320744, 0.02008042111992836, -0.0010199712123721838, 0.012619100511074066, 0.04975108802318573, -0.008320949971675873, -0.014022715389728546, 0.00901939906179905, -0.011692311614751816, 0.0076829432509839535, 0.001560597913339734, 0.003703796537593007, 0.004301507957279682, 0.0064203618094325066, 0.017192600294947624, -0.013142936863005161, -0.011128179728984833, -0.024109935387969017, 0.02307569421827793, 0.01637326553463936, -2.1314983314368874e-05, -0.005016746930778027, -0.009798439219594002, 0.015459909103810787, 0.005731986369937658, -0.007965009659528732, 0.011282644234597683, 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130,Essential Oils and the Brain Module 1,2836.96,2926.24,"page, is the way the essential oils get into your brain. There's multiple pathways for essential oil molecules to get into your brain. We're going to discuss that tonight. That's going to be module one. Module one is going to be how do these molecules actually get into your brain and what are the different pathways to using essential oils and how they affect the brain. Once we understand that, then the rest of it will be kind of easy. Let's go over some basics real quick. Essential oils are complex mixtures of 20 to 300 different molecules, individual isolated molecules that have different chemistry. Here's just an example of different molecules that you may find in essential oil. Depending on the oil, it's going to have a different mix of these different molecules. An essential oil is not just one molecule. It's always a blend of different molecules. There's tens of thousands of different essential oil molecules that can be used to make up a central oil from a specific plant species.",201,"[-0.006308003328740597, 0.015942808240652084, 0.004415279254317284, -0.05036066845059395, -0.023888373747467995, 0.015115952119231224, 0.0039017244707792997, -0.02133028768002987, -0.025787556543946266, 0.0004336146521382034, -0.019844532012939453, 0.020516352728009224, -0.021214012056589127, 0.026872804388403893, -0.013875668868422508, 0.014263257384300232, 0.04072263464331627, 0.004628452938050032, -0.007215606514364481, 0.004334531724452972, -0.012021704576909542, -0.00024951010709628463, 0.014134061522781849, -0.009121250361204147, -0.001451034564524889, 0.02506405860185623, 0.02144656516611576, -0.020245039835572243, -0.028268123045563698, -0.018862642347812653, 0.0023917441722005606, 0.04136861488223076, -0.014831720851361752, 0.0031184726394712925, 0.002475721761584282, 0.012880858965218067, 0.007906805723905563, -0.024159684777259827, 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131,Essential Oils and the Brain Module 1,2934.88,3005.76,"interact with various biomolecules in our cell. The biggest category of molecules that the essential oil molecules will interact with is the proteins. So that's what we call the cellular interaction network. Each one of these dots is representing a specific protein in our cells. These proteins have a specific function. These are proteins that our cells normally make. These are the worker bees, the factories inside our cells that do all the work to make the cell function and run. So each protein has a job to do. What happens is each one of these molecules that's in the essential oil will bind to and specifically target and interact with a specific protein in this network and modulate its function. So it's basically perturbing or changing or affecting the activity of each of the proteins that's in this interaction network. So you can see that here in this diagram, you have these molecules and those get inside the cell and then start to interact with the different proteins.",191,"[-0.030599532648921013, -0.009271396324038506, -0.015195151790976524, -0.04022400081157684, -0.014135937206447124, 0.015940524637699127, -0.00339667871594429, 0.002260638400912285, -0.01498592458665371, -0.007100660819560289, -0.022125815972685814, 0.019157398492097855, -0.015809757634997368, 0.010762142948806286, -0.010925602167844772, 0.018320489674806595, 0.030102616176009178, 0.010775219649076462, -0.010010231286287308, 0.01995508000254631, -0.034862544387578964, 0.01554822362959385, -0.00925831962376833, -0.012605961412191391, 0.003962247166782618, 0.03269180655479431, 0.03096568025648594, -0.04074706882238388, -0.022125815972685814, -0.02391732670366764, -9.8177588370163e-05, 0.03405178710818291, -0.028402643278241158, 0.007937571033835411, -0.002188716549426317, 0.004544161260128021, 0.010415609925985336, 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132,Essential Oils and the Brain Module 1,3010.48,3117.76,"also take them into your GI tract through ingestion. Those are the three main ways you can get essential oils into your body. Okay. Now we're going to talk through each one of those and what the differences are, what the benefits are, what you want to look out for. I'm going to give you a table at the end that summarizes all of this so it makes sense. When you topically apply essential oils, the oils are going to go through the epidermal layer here, the stratum corneum, and then into the lower layers here into the dermal layers. And eventually these molecules will make themselves into the capillaries and then into your veins and then into your bloodstream systemic blood circulation. Okay. 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133,Essential Oils and the Brain Module 1,3123.54,3206.16,"work together to penetrate the epidermal layer. Now the molecules actually travel in between the cells. They don't actually go through the cells. So in between the cells, so in your skin you have these dead protein rich corneocytes. Okay, so these are basically keratinocytes. They're filled with keratin cells, but they're basically dead, right, nonliving cells that have basically died and formed the outer layer of your skin. Okay. So the essential oil molecules are actually not going to travel through the cells. It's going to travel intracellularly in between the cells. Okay. So in between the cells there are lipids here. There's neutral lipids, sterols, and ceramides, which are basically just lipids or fat molecules that surround these cells. Okay. So these are called intracellular lipids. 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134,Essential Oils and the Brain Module 1,3219.06,3329.08,"So when they get together in groups in a collective team, they can actually work together to get through your skin faster than they could if it was just one constituent by itself. Okay. So that's how basically these molecules get through your skin topically. And the timing of that, the kinetics of that is anywhere from five to 20 minutes. There's been studies that have been done to show how fast the rate of permeation absorption into your bloodstream and then the peak concentration of your blood. For example, this study here in 1992 was lavender oil. They applied it to the abdomen in the 2% dilution in peanut oil and they measured two constituents, linalool and linalyl acetate, which are two constituents in lavender. 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135,Essential Oils and the Brain Module 1,3339.96,3434.88,"So the skin is a relatively fast way to deliver essential oil molecules directly into your bloodstream. Once they get into your bloodstream, they're going to travel throughout your entire body basically and then interact with the different cells and tissues and organs that the blood interacts with as it travels through your body. But eventually, like I said, they will be cleared from your body and they will also make their way into your brain through the blood-brain barrier, which we're going to discuss in a separate module, but they will get into the actual brain tissue as well through the blood-brain barrier. So here is a graph. No one's actually done a study of the different locations on your body and how essential oils absorb in through there. So you have to use other data that was provided by other types of molecules that were studied and then indirectly infer how that translates to essential oils.",176,"[-0.017055165022611618, 0.005564663093537092, -0.0023428478743880987, -0.04917103797197342, -0.0032074323389679193, 0.013398660346865654, -0.010585964657366276, -0.02532704919576645, -0.02163218893110752, -0.002370015950873494, 0.00270082731731236, 0.004915825556963682, -0.006497967056930065, 0.00849562045186758, -0.022680556401610374, -0.0001541189558338374, 0.04244614019989967, -0.00021394867508206517, -0.008514797315001488, 0.010752169415354729, -0.009844435378909111, -0.008348592557013035, -0.004222240298986435, 0.007408896926790476, -0.008828029967844486, 0.030402686446905136, 0.025314263999462128, -0.02255270816385746, -0.021414844319224358, -0.008796066977083683, -0.0028254808858036995, 0.024086905643343925, -0.018320878967642784, -0.015508182346820831, -0.0013767826603725553, 0.008016183041036129, 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136,Essential Oils and the Brain Module 1,3446.96,3543.84,"there is so thin. Okay. And you can also see like the scalp behind the ear. It's also a very quick way to get molecules into your body. And then the foot. Now, this is a common misnomer that a lot of people teach that the foot is the fastest way to get essential oils into your body. And that is not true. I actually have a frequently asked question, article about that whole topic about the foot. The foot does not deliver molecules into your bloodstream faster than any other location in your body. In fact, it's slower. Like it's one of the slowest points in your body to apply something to get something into your system. But I believe it acts as a time release mechanism in that the molecules actually absorb into the fat padding tissue there, the thick padding, and then it slowly releases those molecules into your bloodstream over time.",178,"[-0.021213389933109283, 0.01614147238433361, -0.002878214931115508, -0.03882819414138794, -0.004905677866190672, 0.008116370067000389, -0.02372979000210762, -0.023599406704306602, -0.01767999678850174, -0.005195781122893095, 0.013468611985445023, 0.023234331980347633, -0.00020525208674371243, 0.016806427389383316, -0.024811971932649612, -0.008481443859636784, 0.04185309261083603, 0.0037191882729530334, 0.01035244669765234, 0.0050523593090474606, -0.001849815365858376, 0.008983420208096504, -0.005329424049705267, -0.004155972972512245, 0.003207433270290494, 0.027875984087586403, 0.02082223817706108, -0.012014836072921753, -0.04135763272643089, -0.020248550921678543, -0.001095221028663218, 0.013872800394892693, -0.01760176755487919, 0.003354114480316639, 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137,Essential Oils and the Brain Module 1,3549.62,3666.12,"So that's what's going on with the foot. And that's why I think that a lot of people see benefit when they apply essential oils to the bottom of their foot because they're getting a response over a longer period of time. It's not, I mean, most people think, well, the faster I get it into my bloodstream, the better off I'm going to be. And that's not true. Why would that make a difference? Why does it matter how fast it gets into your bloodstream? That's not the question. The question is, what is its concentration and over what period of time is it maintaining that concentration? So quicker is not necessarily better. So don't make that false connection in your mind. So I think there's a lot of benefit to putting essential oils on the bottom of your feet because it acts as a time release system.",176,"[-0.004365736152976751, 0.012364658527076244, 0.025675391778349876, -0.030615998432040215, -0.01679280959069729, 0.001427323091775179, -0.020774204283952713, -0.03731735423207283, -0.016569431871175766, 0.0026920398231595755, -0.002273205202072859, 0.032087668776512146, -0.01750236563384533, 0.004493850748986006, -0.027593819424510002, -0.018842635676264763, 0.054399244487285614, 0.021352360025048256, 0.002274847589433193, 0.012279249727725983, -0.005735572427511215, -0.009230789728462696, -0.017686324194073677, -0.007910228334367275, 0.008797172456979752, 0.0023044124245643616, 0.00996005441993475, -0.022350993007421494, -0.026726584881544113, -0.018711237236857414, -0.0036167611833661795, 0.015518237836658955, -0.010144013911485672, 0.003541206708177924, -0.013560391031205654, -0.003955114167183638, 0.010879849083721638, -0.03019552119076252, 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138,Essential Oils and the Brain Module 1,3676.68,3746.64,"A couple of other notes I'll make is dilution. So diluting in a carrier oil is a good thing for several reasons. One is, of course, if you apply any oil neat to your skin, there's always a greater chance of reaction in terms of sensitivity. You might get a red irritation there, but there's also allergic response you can develop over time if you don't dilute your oils. It's called haptanization. I have a frequently asked question article on being allergic. Most people don't think you can become allergic to essential oils, but you can. It's called haptanization. And what happens is the actual essential oil molecules interact and bind with specific proteins in your skin. And once they chemically modify the protein in your skin, then your immune system can recognize that protein your body normally makes as a foreign invader because it's been chemically modified. 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139,Essential Oils and the Brain Module 1,3753.0,3838.04,"oils. So if you use oils for a long period of time, undiluted, neat on your skin, you might not see any reaction when you first start that, but then a year later all of a sudden now you're getting welts. You've developed some kind of antibody to the haptan, which is the modified protein from the oil. So there's plenty of research articles about this. It doesn't have anything to do with the purity of the oil. I know that's a common thing that people say is, well, if it's a non-pure oil, that's why you're allergic to it. So no, that's not the reason. But again, it's rare. But it's something to be aware of. 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140,Essential Oils and the Brain Module 1,3850.8,3904.6,"evaporating away. But if you put it in a carrier oil, which is a larger molecular weight vegetable oil, those molecules are much larger in a vegetable oil. And so the smaller molecules basically get fixed in there. It's called fixation. And then that will deliver those smaller molecules into your skin. The third thing is with dilution is you put it in a carrier oil and you rub it on your skin is that you're applying the oil now to a larger surface area. So imagine if you just took one drop of a neat oil and you put it on your skin, it's basically only going to cover one very small area of your skin, patch of your skin. But if you put it in a carrier oil, you can rub it on your skin in a larger surface area. 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0,,,,"Text chama ples Hey everybody, welcome to module 5 of essential oils and the brain. I'm excited about tonight. Tonight we're going to discuss neurodegenerative disorders and essential oils and how they may be able to help with those types of situations. So thank you for participating in this entire series. I'm very appreciative and very grateful for every single one of you that have been part of this series. This will be our last module. So five modules basically complete this entire series. And I think this last module here will help round things out. The modules will all remain in this group indefinitely as videos, all the live videos that I produce will be in this group. So you can go back and watch them as many times as you want. You also were provided a link that gave you access to download the slides and the video for this entire course. 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141,,,,"So you can't get a really big dose from breathing in oils. I mean, the amount that you can actually get into your bloodstream through breathing in something is very small compared to what you can deliver into your bloodstream through topical application or even through ingestion. So breathing in is great and we're going to explain here in a second how it affects the olfactory limbic response, which is really why you want to use inhalation. But you're also going to get delivery of molecules into your bloodstream through the lung tissue, but the concentration is going to be really small. So let's talk about that. So in your lung you have these avioli, these little airbags, basically very small. The skin there, the epithelial tissue is very thin. It's really, really thin. It only takes four seconds for blood to move through the lung capillary network. 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142,,,,"love lipids, they're going to move right through the epithelial tissue of the lung. And right into the aviolites, there's a really large surface area inside your lung tissue because of the number of avioli and the small structures that they make. It just really increases the total surface area. And so you have this really efficient delivery mechanism for molecules into your bloodstream. Now this is basically showing you, one of the biggest questions people have is, well if you breathe essential oils in, does it basically leave residue? Does it build up in your lung tissue? So I guess people are thinking you breathe in smoke or you breathe in something else, that can hurt your lungs because you're basically leaving a residue in your lungs. That's not the case with essential oil molecules. Those molecules are not left behind, they do not build up a residue, they do not stay around and build up in concentration in your lung tissue.",189,"[-0.010921275243163109, 0.015922484919428825, -0.001936163636855781, -0.03811945021152496, -0.014373553916811943, 0.007698711473494768, -0.023640885949134827, -0.019190991297364235, -0.028642095625400543, 0.005851151887327433, 0.002994490321725607, 0.01478047575801611, -0.0009295226191170514, 0.03297385200858116, -0.008650384843349457, 0.008663511835038662, 0.037489376962184906, -0.0030387924052774906, -0.013822238892316818, -0.019939202815294266, -0.01258834544569254, 0.0020182044245302677, -0.007370548322796822, -0.007816850207746029, 0.01130850799381733, 0.008834157139062881, 0.035940445959568024, -0.029167156666517258, -0.02490103244781494, -0.025898650288581848, 0.0014660696033388376, 0.0402984581887722, -0.01408477034419775, -0.006963625550270081, -0.010579985566437244, 0.010376524180173874, 0.00538844196125865, 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143,,,,"into your bloodstream, like the padding of your foot or the back part of your ear. And you can see here in the lung tissue, it's only 0.2 micrometers. And if you remember in the foot, the bottom of your foot, it was 600 micrometers or the average part of your skin is about 15 micrometers. So the lung tissue is 0.2 micrometers. So that's why it gets into your bloodstream so much faster. Okay, now, so basically when you breathe in essential oil molecules, they're going to go two different pathways. One is they're going to go into the upper nasal cavity and then interact with olfactory receptors, which we'll talk about here in a minute. 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144,,,,"your brain like it does when it gets in your blood. That's actually a different type of response, an electrical response. So in our upper nasal cavity, we have 10 million cells, olfactory cells, that have 350 different protein molecules that are called olfactory receptors. These protein molecules specifically recognize certain chemical shapes that make up different odors. So it's like a puzzle, like a key fitting into a lock. So think of the olfactory receptor, the protein, being a lock and the odorant molecule, the chemical being the key. And so if the key fits into the lock, it will turn on that protein receptor and then send the electric signal to your brain. So there's 350 different basically locks. Now an individual molecule itself can turn on, can fit into more than one lock. It can turn on this receptor and this receptor and this receptor, let's say. So it could be seven different receptors this one molecule turns on. 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145,,,,"permutations is going to give you a different sense or a different perception of odor. So we are very good at perceiving odor. We can perceive a molecule that's an odorant down to the very low concentration of one part per billion. So if there's a billion air molecules and only one molecule that has an odor, we can sense it. Now, dogs and rabbits, they have much larger number of these cells, olfactory cells. They have 100 million or 220 million for dogs. So they can even get down to parts per trillion or parts per quadrillion and be able to smell a molecule like from miles away. So we're not that sensitive, but our olfactory receptors are very receptive. One molecule entering into our nose can actually set off that electrical response from interacting with one of the receptors. So you can see here an image of that. So here is our nasal cavity here. 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146,,,,"Here's your olfactory bulb. This here being zoomed in. So you have the receptors, this nerve, which gets activated electrically, sends a signal. Those get accumulated and collected in these different, what they call glomuli, which is this. So like all the red ones are being collected and then stimulate this red guy. So you see you have these red, red, red, red. So those are spread out. So there's hundreds of millions of these. Right? So you have a very large concentration of them. And then they are basically, if any one of them gets stimulated from a molecule, they're basically all going to sum up their action potentials and then send a signal to the brain. So this olfactory bulb, what it's doing is accumulating and summing all the different receptors individually and spatially mapping it. And then it's going to collect all those signals, organize them and send it to the brain.",193,"[-0.023152675479650497, 0.012310138903558254, 0.01925594173371792, -0.0043585230596363544, -0.022241750732064247, 0.021432040259242058, -0.005395965185016394, -0.017067192122340202, -0.03534894809126854, -0.02917490154504776, 0.013651222921907902, 0.017231663689017296, -0.009197811596095562, 0.01251889206469059, -0.01654846966266632, -0.005674303509294987, 0.03674063831567764, 0.020736195147037506, -0.016282783821225166, 0.02153325453400612, -0.006436570547521114, 0.008103436790406704, -0.016358694061636925, -0.008906821720302105, 0.011114549823105335, 0.002403829712420702, 0.006471362896263599, -0.03299572691321373, 0.0023279192391783, 0.007527782581746578, -0.020698240026831627, 0.015321251936256886, -0.013929560780525208, -0.005968456156551838, -0.0007792678661644459, 0.02079945243895054, 0.021976064890623093, -0.008704394102096558, -0.013107198290526867, -0.0059874337166547775, 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147,,,,"So what's happening is the molecules bind here to a specific receptor and stay there. Okay? Now that receptor activates and sends an electrical signal, a current basically through a wire, which is the nerve ending. And then that makes its way into your brain to the olfactory center, limbic center of your brain, which we'll talk about in a second. So it's an electrical signal being sent. The molecules aren't getting into your brain interacting. Now, but there are molecules getting into your brain when you breathe through your lung tissue, it gets into your bloodstream. Then the bloodstream, your blood will travel to your brain through, and then go through the blood brain barrier. And then those molecules will make their way into the brain and then interact with different proteins in your brain. That's a different response. 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148,,,,"You're still getting activation, electrical signals sent to your brain. And then that's modulating the limbic center of your brain, but somehow your brain's not interpreting that and perceiving that as an odor. So what you're losing there is the perception of odor, not necessarily the physiological function of the molecule, uh, in terms of that. So, so that's one thing. The other thing is if when you breathe in essential oil molecules, the Ganner topically apply them and they get into your bloodstream, they get to your brain through the blood brain barrier, the olfactory response doesn't matter. Again, that's a different pathway. So if you lost your sense of smell, then it's possible that you may lose the olfactory limbic response of the oil, but not the systemic response due to the molecules presence in your bloodstream, then traveling to your brain, which is different.",184,"[-0.002136506838724017, -0.0027945186011493206, 0.0033063055016100407, -0.015428341925144196, -0.023538945242762566, 0.004513472318649292, -0.0030447253957390785, -0.023694917559623718, -0.026372456923127174, -0.006079702638089657, -0.011275557801127434, 0.036185767501592636, -0.030050823464989662, 0.0016848347149789333, -0.01574028842151165, 0.008455043658614159, 0.05209502577781677, 0.016208207234740257, 0.002524815034121275, 0.03041476011276245, -0.014713465236127377, -0.006791329942643642, -0.005130866076797247, -0.009683331474661827, 0.017858924344182014, 0.013335702940821648, 0.02531963773071766, -0.03070071153342724, -0.033690195530653, 0.006469635292887688, 0.0004015089652966708, 0.030934670940041542, -0.01076214574277401, 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149,,,,"stimuli. So this is published in science. If you want to go read that. Um, and they think that that estimate is actually conservative. So it's just an amazing, diverse, um, capability that humans have. And this is all going to the brain. Okay. So this olfactory bulb is basically sending the signals to the limbic system in your brain, to the cerebral cortex, which we'll talk about here in a second. So, um, here is, um, if you were to look at one of these little receptors, these proteins that reside at the end of the nerve endings here, if you zoomed in here with a really high power microscope to see what those receptors look like, this is what kind of what you would see. This is a artistic representation of it. So this is a, this gray loopy thing. This is a olfactory receptor protein, one of the 350, okay. 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150,,,,"And then the surrounding, um, region is that pocket inside that receptor, this, this bigger receptor here. So there's 350 of these different protein molecules, different, and then, and then there's trillions of them, right? So it's copied trillions of times throughout your nasal cavity. So once one molecule comes along, it recognizes it binds to it, it activates it and sends an electrical stimulation, a stimulation to your, to your brain. So this molecule is now not getting into your bloodstream and then, you know, causing some kind of reaction that way. So once the olfactory bulb is stimulated, um, this, this thing here, once all the signals are accumulated and organized, like I showed you earlier, they send, uh, its signal, um, to your limbic system. So limbic system is basically these structures here in your brain.",179,"[-0.023223767057061195, 0.018494190648198128, -0.0016932658618316054, -0.009696919471025467, -0.017877288162708282, 0.02285105735063553, -0.0038395687006413937, -0.022799648344516754, -0.04508521035313606, -0.00033997854916378856, -0.004993045702576637, 0.00040745214209891856, -0.017054753378033638, 0.0035214789677411318, 0.0012522777542471886, -0.018237147480249405, 0.03506056219339371, -0.010403784923255444, -0.014291549101471901, 0.010924295522272587, -0.010403784923255444, 0.0008136993856169283, -0.007377112749963999, -0.01502411998808384, 0.019753696396946907, 0.010076056234538555, 0.017003344371914864, -0.0328500010073185, -0.005613160319626331, -0.011836796067655087, -0.01597517542541027, 0.013199119828641415, -0.029045775532722473, 0.004601056221872568, -0.008495246060192585, 0.004919146187603474, 0.009028608910739422, -0.011309859342873096, -0.001847491250373423, 0.005372182931751013, 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151,,,,"that are automatic. So they're going on behind the scenes in an automatic way and, uh, you don't even realize these things are happening. So we'll talk about what some of those functions are. So in the hippocampus, okay, what you see here, so the hippocampus is right here. Okay. It's part of the limbic system here. The hippocampus is basically where memories are consolidated and it's also, uh, where a lot of your mental focus, uh, comes from. The amygdala, which I showed you earlier, it's just here. Okay. The amygdala, uh, is, is really an emotional response center and it has a lot to do with anxiety and fear. Okay. The hypothalamus, okay. Um, the hypothalamus is really responsible for regulating a lot of the different neuroendocrine responses, uh, that, that modulate hormones in our body through three different axes.",195,"[-0.038110844790935516, 0.016984455287456512, 0.03283240646123886, -0.02350042574107647, -0.05101650580763817, 0.006260255817323923, 0.004015655722469091, -0.024194957688450813, 0.0069516305811703205, -0.007229443173855543, -0.002080437960103154, 0.0066801318898797035, -0.019838349893689156, 0.006654876284301281, -0.00028491581906564534, -0.012867777608335018, 0.032983940094709396, 0.005641491152346134, -0.013284496031701565, -0.005613078363239765, 0.004328195005655289, -0.022098734974861145, 0.006762212608009577, -0.02009090594947338, 0.006269726902246475, 0.0021830392070114613, 0.00858062319457531, -0.024838978424668312, -0.004283997695893049, -0.0370248518884182, -0.00669907359406352, -0.021328436210751534, -0.009363549761474133, 0.0005201094900257885, -0.01055056694895029, -0.007261012680828571, 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152,,,,"which is basically going to change hormone regulation, which is pretty neat. Um, the septal nuclei nuclei, uh, which is your pleasure, one of your pleasure centers, and then also learning through reward. Also like, um, you know, the, uh, Pavlov response, that type of thing, uh, the cingulate cortex, um, memory and emotion. Okay. So the limbic system is connected to memory processing in your, in your body, emotions, uh, hunger, thirst. So regulation when you, your appetite, you know, how hungry you are, when you want to eat. So a lot of this can be, um, you know, controlled, uh, and is involved with, uh, weight management, right? So, uh, the, the ability to suppress appetite can, can be modulated through this pathway.",176,"[-0.027184806764125824, 0.012471513822674751, 0.029503891244530678, -0.02218589559197426, -0.03628076612949371, 0.009501799009740353, 0.00711185485124588, -0.01010733749717474, -0.016362419351935387, -0.02687559649348259, -0.023641763255000114, 0.011054296046495438, -0.023190831765532494, 0.004882958251982927, 0.006957249250262976, 0.008709445595741272, 0.0449129082262516, -0.009765916503965855, -0.01780540496110916, 0.003887685015797615, -0.000879318977240473, -0.01580841653048992, 0.005965196993201971, -0.03179720416665077, 0.01664586365222931, -0.005511043127626181, 0.003346565645188093, -0.02352580986917019, 0.007337321061640978, -0.011189576238393784, -0.006000627297908068, 0.007717393338680267, -0.00845176912844181, 0.0036300092469900846, -0.007788253948092461, -0.00693792337551713, 0.012851585634052753, -0.014996737241744995, 0.005849242676049471, 0.014674642123281956, 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153,,,,"it's basically modulating pathways electrically. Now there's another pathway, which we already talked about where the molecules actually go in through the blood brain barrier. And then the molecules get into your brain that way and then interact with various receptors and modulate the activity of your brain as well. That's different than this. Okay. That's much, much different. It's not the same at all. You can't compare the two. Um, okay. So that, that goes through an inhalation. Now let's talk about ingestion. So this is a lot, there's a lot of misconceptions with ingestion as well. So with, with ingestion, it's the slowest mechanism to get molecules into your system because it's got to go through your GI tract. So it's going to take a couple of hours to get into your system through this pathway. 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154,,,,"If you go through the pathway of ingestion, which we'll talk about. And those are called phase one and phase two reactions that happen in your liver. So then those metabolites that process through your liver get into your bloodstream. Then they're, they're targeted for excretion through urine. So then they're going to pretty much leave your body quickly. So let's take a look at the diagram here. So you ingest essential oils into your stomach and you can see here, this blue is the hepatic portal vein. It's basically collecting venous blood from your upper and lower intestines, right? Your stomach through the, it's collecting from the pancreas and the spleen as well, and the gallbladder. And it's collecting venous blood and then directing it all to the liver.",164,"[-0.0013631791807711124, 0.0070810262113809586, 0.01818224787712097, -0.03349292650818825, -0.04623224958777428, 0.0328403003513813, -0.02532201074063778, -0.024525804445147514, -0.02490432932972908, -0.0027753054164350033, 0.01655067503452301, 0.00864733662456274, -0.022894231602549553, 0.013300581835210323, -0.01670730672776699, -0.012510901317000389, 0.046910982578992844, -0.0020492556504905224, 0.0015034944517537951, -0.002847094787284732, -0.018051723018288612, 0.0012946530478075147, 0.014932154677808285, -0.0035861972719430923, 0.01568920537829399, 0.036677759140729904, 0.031404513865709305, -0.028611261397600174, -0.017464356496930122, 0.0018844667356461287, -0.01769930310547352, 0.004199668765068054, -0.013783527538180351, -0.0022254653740674257, 0.029524942860007286, 0.006330502685159445, 0.0034067241940647364, -0.007485656533390284, -0.020570870488882065, -0.005948714911937714, 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155,,,,"urinary system and then be excreted. Okay. So the molecules are going to get to the rest of your body, but when they get to the rest of your body, they're going to be altered in some way. Okay. So it's much harder to predict what the molecules are going to do once they become chemically modified through your liver. So what I tell people is if you're ingesting essential oils, you should be really ingesting them because you want to do something to your stomach, to your GI tract, or to your liver. Right? Because the molecules are basically making their way to those organs unaltered in high concentration directly targeted to those organs. But once they leave the liver, basically I would say all bets are off. You don't know what the effect is going to be. Does that mean it's bad? No. It just means it's unpredictable.",183,"[0.011881931684911251, -0.002198288682848215, -6.607804971281439e-05, -0.02464449219405651, -0.0332273468375206, 0.01706056110560894, -0.023658713325858116, -0.03049345314502716, -0.02915279194712639, 0.01899268850684166, 0.020293917506933212, 0.009167751297354698, -0.022081466391682625, 0.02162143588066101, -0.019216133281588554, -0.0026024584658443928, 0.05254863202571869, -0.0037196753546595573, 0.0067953080870211124, 0.010120672173798084, 0.0005581977893598378, 0.0022853659465909004, -0.009680356830358505, -0.012578548863530159, 0.007472210098057985, 0.029941415414214134, 0.03714418038725853, -0.041245024651288986, -0.0217002984136343, -0.013459178619086742, 0.0013833775883540511, 0.030782613903284073, -0.0350937582552433, -0.01790175959467888, 0.006131549831479788, 0.00816882774233818, 0.0065357196144759655, -0.01625879295170307, -0.014129509218037128, -0.022778082638978958, 0.026550333946943283, 0.0025613843463361263, 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156,,,,"So all the information that we have is anecdotal. It's what people say. So as you're in these essential oil communities and you're listening to people tell stories about what has happened, that's where you're going to start to collect some of this data. So what I tell people is if you want a known effect for your GI tract, for your liver, ingestion is the best. If you're wanting to do something with another organ in your body, then topical application and inhalation is going to be your best method there. So here is basically your liver and you can see there's a phase one reactions and there's phase two reactions. So when the molecules come through here in the phase one, this is all being regulated by the cytochrome P450 enzyme system and this is what drugs go through, nutrients go through, everything processes through this pathway.",176,"[-0.002045838162302971, 0.023627523332834244, 0.013134513981640339, -0.029945895075798035, -0.03225555270910263, 0.009643481113016605, -0.018649814650416374, -0.005422384012490511, -0.019393153488636017, -0.012192067690193653, 0.00937136635184288, 0.017999393865466118, -0.021025842055678368, 0.02095947228372097, -0.005943384021520615, 0.015225151553750038, 0.05110447481274605, 0.0032338513992726803, -0.0008416475611738861, 0.0221010260283947, -0.021198401227593422, 0.013765024021267891, -0.00995541736483574, -0.012251799926161766, 0.0022781314328312874, 0.024689435958862305, 0.027238022536039352, -0.04446753114461899, -0.014972947537899017, -0.00606616772711277, -0.004679046105593443, 0.005916836205869913, -0.014468539506196976, -0.010035060346126556, 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157,,,,"So when you ingest an oil, they're not in their original native format once it leaves your liver. So that's what you need to know. Very little of any of the original constituent is unmodified as making it into your bloodstream. There is probably a small percentage of the essential oil that you're taking in that's not being modified and it's getting into your bloodstream. Let's say it's 2%. Okay. Really we don't have good data around that but there's going to be a certain percentage that get through in an unmodified native format but the other 98% or so is going to be chemically metabolized. So therefore, in my opinion, you should relegate ingestion to your GI system. So here's a table that looks at the differences. So the organs reached, the total dose, the time of desorption, if the molecules are chemically modified and what some of the unique advantage of that method is and you have topical inhalation and ingestion.",200,"[0.01841619424521923, 0.030698101967573166, -0.0005588367930613458, -0.02615072764456272, -0.036032263189554214, 0.0031971631105989218, -0.0199631005525589, -0.021149951964616776, -0.02644410729408264, 0.006961081176996231, 0.016295865178108215, 0.01448224950581789, -0.021043268963694572, 0.001736936392262578, -0.0023970389738678932, 0.011101724579930305, 0.04651389271020889, 0.010334938764572144, 0.0027287572156637907, 0.007354475557804108, -0.01130842324346304, 0.016882622614502907, -0.003933944273740053, 0.0072344569489359856, -4.909616836812347e-05, 0.022830212488770485, 0.034832075238227844, -0.024683833122253418, -0.014735622331500053, -0.004197318572551012, 0.00047549052396789193, 0.026977524161338806, -0.030858125537633896, 0.0026204069145023823, -0.013695460744202137, 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158,,,,"But what's going to happen first, they're going to go through your bloodstream first to the cells of your body and then as they circulate around and come back through to your liver, your liver will then modify them. So what's happening in topical or inhalation is that those molecules get to your cells first in their native format. But then they are metabolized and excreted. But in ingestion, they're actually being modified first before they reach your cells. See the difference? So the advantage to topical is you can have local treatment, right? And you can apply it to different parts of your body at different rates of absorption. Like I said, with your feet, you can do something over a long extended period of time. And you can actually have a pretty wide dosing range from very low to very high depending on how much you apply. So those are all advantages of topical. Inhalation, there's a couple of advantages.",192,"[0.004123101942241192, 0.027425872161984444, 0.006197825539857149, -0.00681694969534874, -0.03248424828052521, 0.01054486632347107, -0.030613701790571213, -0.034802667796611786, -0.02940179966390133, 0.004785037599503994, 0.015557135455310345, 0.020193979144096375, -0.020852621644735336, 0.01875813864171505, 0.0016680121188983321, -0.002290429314598441, 0.049608953297138214, -0.007027715444564819, -0.0006096559227444232, -0.0039222161285579205, -0.005670911632478237, 0.016439715400338173, -0.01363389939069748, -0.0031647770665585995, -0.00639212504029274, 0.023895548656582832, 0.030218517407774925, -0.025133797898888588, -0.010268236510455608, -0.007310931570827961, -0.00708699319511652, 0.023948241025209427, -0.02523917891085148, -0.012501033954322338, -0.007627079728990793, 0.017967766150832176, 0.0020796635653823614, -0.03759531304240227, -0.0138051463291049, -0.0222752895206213, 0.018481507897377014, -0.007844432257115841, 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159,,,,"Well, it's the only way, but it's very fast when it does happen. And then the delivery into your bloodstream is very fast as well. Like I said, four seconds. The total dose is very low that you're going to get into your bloodstream through inhalation. Just think about it. If you take an oil and you put it in your diffuser, let's say, your diffuser is already diluting your oil 10,000 to one in your diffuser. And then that water is basically very slowly diffused into a larger room that's maybe 60,000 times the volume of the diffuser when you look at the volume of it. So the concentration of the molecules in each one of those steps from putting it in your diffuser to then diffusing in your room, it's very, very low. 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160,,,,"Other people might tell you there are other opinions about that. That's just my opinion. Okay. But I gave you a scientific rationale behind my opinion. All right. So olfactory vascular systemic, this is what we've been talking about this whole time. This is what I want you to really take home tonight and understand. Most people do not understand this. They confuse the two, they don't even know there's a difference. So the olfactory limbic response can only be stimulated via inhalation through the binding of the molecules to the olfactory receptors. It only takes one. It's not the same thing as getting into your bloodstream and then traveling and permeating to the cells of your body. Okay. The systemic response, that's what that is. That's when the molecules actually get into your bloodstream, travel around, then permeate and get inside one of your cells of your body. That's the systemic response. 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161,,,,"They're not the same and they elicit different types of effects. Okay. So that makes up module one of tonight. Hopefully that was useful to you. That sets the stage for how you get the molecules to your brain and what the two different modes are, systemic versus olfactory limbic. Now, so in the remaining modules, we're going to actually start going over specific data. We're going to go over some different studies and what we know about how the molecule is going to affect different functions of the brain, whether it be memory or emotion or hormonal and those types of things. We're going to show how those effects take place. So that's what's going to happen in the remaining modules. So again, I've got the frequently asked question database, seven module series, other classes and books for you tonight, 30% off if you get two or more. So make sure you do that tonight. 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162,,,,"I'll try to get to those. And again, in maybe two days, look in the folder you were given. If you want to get this download to slides because it will be uploaded along with this video will also be uploaded, but this video will also be in the Facebook group so you can watch it. If you didn't get the initial email to know where to get the Dropbox folder, please private message me in Facebook and say, Hey, I didn't get the email. But first, please, before you do that, check your junk and your spam. So when you ordered the course, if you didn't have your email address and Etsy, you know, correct, it may not sent you the email or it may went to your junk file spam. So check that first. If you don't have it, private message me, say, Hey, I need the email. And then I'll manually email you the links to the Dropbox.",193,"[-0.053652554750442505, -0.02331284061074257, -0.005280061159282923, -0.022533543407917023, -0.021899539977312088, 0.012277214787900448, -0.025373350828886032, -0.039625223726034164, 0.005247040186077356, -0.0007454495062120259, 0.019112566486001015, -0.0087241530418396, 0.005283363163471222, 0.012831968255341053, 0.020235281437635422, -0.003959220368415117, 0.01541421189904213, 0.005395634565502405, 0.014872667379677296, -0.008294880390167236, -0.014040537178516388, 0.014555665664374828, 0.0044644419103860855, -0.01805589348077774, -0.019535236060619354, -0.004596525803208351, 0.01863706298172474, 0.008024107664823532, -0.01829364523291588, -0.0011499570682644844, -0.00764766801148653, 0.0007772322278469801, -0.014132996089756489, -0.01886160671710968, -0.023946844041347504, -0.011854546144604683, -0.0015569410752505064, -0.002466670237481594, 0.008096753619611263, -0.003886573947966099, 0.019984321668744087, 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