Mahmoud Amiri
commited on
Commit
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ee52ba9
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Parent(s):
ae7273f
update example
Browse files
README.md
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---
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title: Lit2Vec
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emoji: 🧪
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colorFrom: blue
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colorTo: green
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hf_oauth: true
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hf_oauth_scopes:
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- inference-api
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short_description:
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---
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🔬 Model: [`Bocklitz-Lab/lit2vec-
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title: Lit2Vec Subfield Classifier
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emoji: 🧪
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colorFrom: blue
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colorTo: green
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hf_oauth: true
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hf_oauth_scopes:
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- inference-api
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short_description: Lit2Vec Subfield Classifier
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---
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This Space takes a chemistry abstract or summary, encodes it with intfloat/e5-large-v2, and predicts one or more chemistry subfields using a multilabel MLP classifier.
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🔬 Model: [`Bocklitz-Lab/lit2vec-subfield-classifier-model`](https://huggingface.co/Bocklitz-Lab/lit2vec-subfield-classifier-model)
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app.py
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label="Paste abstract / summary",
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placeholder="Paste your chemistry abstract here…",
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lines=12,
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value="
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"demonstrating improved activity via ligand tuning and support engineering."
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)
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run_btn = gr.Button("Predict subfield(s)")
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label="Paste abstract / summary",
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placeholder="Paste your chemistry abstract here…",
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lines=12,
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value="Ultraviolet B (UVB; 290~320nm) irradiation-induced lipid peroxidation induces inflammatory responses that lead to skin wrinkle formation and epidermal thickening. Peroxisome proliferator-activated receptor (PPAR) α/γ dual agonists have the potential to be used as anti-wrinkle agents because they inhibit inflammatory response and lipid peroxidation. In this study, we evaluated the function of 2-bromo-4-(5-chloro-benzo[d]thiazol-2-yl) phenol (MHY 966), a novel synthetic PPAR α/γ dual agonist, and investigated its anti-inflammatory and anti-lipid peroxidation effects. The action of MHY 966 as a PPAR α/γ dual agonist was also determined in vitro by reporter gene assay. Additionally, 8-week-old melanin-possessing hairless mice 2 (HRM2) were exposed to 150 mJ/cm2 UVB every other day for 17 days and MHY 966 was simultaneously pre-treated every day for 17 days to investigate the molecular mechanisms involved. MHY 966 was found to stimulate the transcriptional activities of both PPAR α and γ. In HRM2 mice, we found that the skins of mice exposed to UVB showed significantly increased pro-inflammatory mediator levels (NF-κB, iNOS, and COX-2) and increased lipid peroxidation, whereas MHY 966 co-treatment down-regulated these effects of UVB by activating PPAR α and γ. Thus, the present study shows that MHY 966 exhibits beneficial effects on inflammatory responses and lipid peroxidation by simultaneously activating PPAR α and γ. The major finding of this study is that MHY 966 demonstrates potential as an agent against wrinkle formation associated with chronic UVB exposure."
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)
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run_btn = gr.Button("Predict subfield(s)")
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