MCP_CLIENTE_LATEX_V3 / fetch_papers.mjs
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import fs from 'fs/promises';
import path from 'path';
const targetDir = 'E:\\Archivos (meanwhile)';
const referencesText = `Ahmad, N., Khan, P., Khan, A., Usman, M., Ali, M., Fazal, H., Durrishahwar, Uddin, M. N.,
Hano, C., & Abbasi, B. H. (2021). Elicitation of submerged adventitious root cultures
of Stevia rebaudiana with Cuscuta reflexa for production of biomass and secondary
metabolites. Molecules, 27(1), 14. https://doi.org/10.3390/molecules27010014
Ahmad, N., Rab, A., Ahmad, N., & Fazal, H. (2018). Differential pH-induced biosynthesis
of steviol glycosides in submerged root cultures of Stevia rebaudiana. Sugar Tech, 21,
465-472. https://doi.org/10.1007/s12355-018-0589-z
Ali, M. B., Hahn, E.-J., & Paek, K.-Y. (2007). Methyl jasmonate and salicylic acid induced oxidative stress and accumulation of phenolics in Panax ginseng bioreactor root
suspension cultures. Molecules, 12(3), 607-621. https://doi.org/10.3390/12030607
Ali, S., et al. (2024). Influence of abiotic and biotic elicitors on organogenesis, biomass
accumulation, and production of key secondary metabolites in Asteraceae plants.
International Journal of Molecular Sciences, 25, 4197. https://doi.org/10.3390/ijms25084197
Álvarez-Robles, M. J., López-Orenes, A., Ferrer, M. A., & Calderón, A. A. (2016). Methanol elicits the accumulation of bioactive steviol glycosides and phenolics in Stevia
rebaudiana shoot cultures. Industrial Crops and Products, 87, 273-279. https://doi.org/10.1016/j.indcrop.2016.04.054
Aponte, H., Melendez, Y., & Otiniano, R. (2022). Potencial de la biotecnologia vegetal en la
produccion de metabolitos de alto valor en el Peru. Ecologia Aplicada, 21(1), 45-56.
https://doi.org/10.21704/rea.v21i1.1845
Aydin, M., et al. (2025). Effect of jasmonic acid on the elicitation of phenolic compounds
and naphthodianthrones in extitHypericum perforatum L. Horticulturae, 11, 1210.
https://doi.org/10.3390/horticulturae11101210
Bai, X., Lee, H.-S., Han, J.-E., Murthy, H. N., & Park, S.-Y. (2025). Enhancement of phenolic and polyacetylene accumulation in Lobelia chinensis (Chinese lobelia) plantlet
cultures through yeast extract and salicylic acid elicitation. Horticulturae, 11(6), 612.
https://doi.org/10.3390/horticulturae11060612
Bayraktar, M., Naziri, E., Akgun, I. H., Karabey, F., Ilhan, E., Akyol, B., Bedir, E., & Gurel,
A. (2016). Elicitor induced stevioside production, in vitro shoot growth, and biomass
99100
accumulation in micropropagated Stevia rebaudiana. Plant Cell Tissue and Organ
Culture, 127, 289-300. https://doi.org/10.1007/s11240-016-1049-7
Bayraktar, M., Naziri, E., Karabey, F., Akgun, I. H., Bedir, E., & Gurel, A. (2018). Enhancement of stevioside production by using biotechnological approach in in vitro culture
of Stevia rebaudiana. International Journal of Secondary Metabolite, 5(3), 244-253.
https://doi.org/10.21448/ijsm.496724
Bernabé-Antonio, A., Castro-Rubio, C., Rodríguez-Anda, R., Silva-Guzmán, J. A., ManríquezGonzález, R., Hurtado-Díaz, I., Sánchez-Ramos, M., Hinojosa-Ventura, G., & RomeroEstrada, A. (2023). Jasmonic and salicylic acids enhance biomass, total phenolic content, and antioxidant activity of adventitious roots of Acmella radicans (Jacq.) R.K.
Jansen cultured in shake flasks. Biomolecules, 13(5), 746. https://doi.org/10.3390/biom13050746
Blinstrubiene, A., Burbulis, N., Juskeviciute, N., Vaitkeviciene, N., & Zukiene, R. (2020).
Effect of growth regulators on Stevia rebaudiana Bertoni callus genesis and influence
of auxin and proline to steviol glycosides, phenols, flavonoids and antioxidant activity
in vitro. Molecules, 25(12), 2759. https://doi.org/10.3390/molecules25122759
Bogado-Villalba, L., Nakayama Nakashima, H. D., Britos, R., Iehisa, J. M., & Flores Giubi,
M. E. (2020). Genotypic characterization and steviol glycoside quantification in a
population of Stevia rebaudiana Bertoni from Paraguay. Journal of Crop Science
and Biotechnology. https://doi.org/10.1007/s12892-020-00066-1
Bovy, A., de Vos, R., Kemper, M., Schijlen, E., Pertejo, M. A., Muir, S. R., Collins, G.,
Robinson, S., Verhoeyen, M., & Hughes, S. (2002). High flavonol tomatoes resulting
from the heterologous expression of the maize transcription factor genes Lc and C1.
Plant Cell, 14, 2509-2526. https://doi.org/10.1105/tpc.004218
Boydak, E., & Omay, I. (2024). Plant density effect on agronomic parameters of Stevia
rebaudiana. Research Square. https://doi.org/10.21203/rs.3.rs-4835008/v1
Butelli, E., Titta, L., Giorgio, M., Mock, H.-P., Matros, A., Peterek, S., Schijlen, E. G. W. M.,
Hall, R. D., Bovy, A. G., Luo, J., & Martin, C. (2008). Enrichment of tomato fruit
with health-promoting anthocyanins by expression of select transcription factors. Nature Biotechnology, 26, 1301-1308. https://doi.org/10.1038/nbt.1524
Celaya, L. S., Taiariol, D. R., Valle, S., & Kolb Koslobsky, N. (2020). Glicósidos de esteviol y
compuestos fenólicos en infusiones de Stevia rebaudiana dependiendo de la variedad.
Revista de Ciencia y Tecnología, 33. https://doi.org/10.36995/j.recyt.2020.33.010
Ceunen, S., & Geuns, J. M. C. (2013). Glucose, sucrose, and steviol glycoside accumulation
in Stevia rebaudiana grown under different photoperiods. Biologia Plantarum, 57(2),
390-394. https://doi.org/10.1007/s10535-012-0289-6101
Chaplin, M. F. (2012). Adapting the reducing sugars method with dinitrosalicylic acid to
microtiter plates and microwave heating. Journal of the Brazilian Chemical Society,
24, 1-6. https://doi.org/10.1590/s0103-50532013005000003
Cohen, J. (1988). Statistical Power Analysis for the Behavioral Sciences (2.a ed.). Lawrence
Erlbaum Associates.
Everette, J. D., Bryant, Q. M., Green, A. M., Abbey, Y. A., Wangila, G. W., & Walker, R. B.
(2010). Thorough study of reactivity of various compound classes toward the FolinCiocalteu reagent. Journal of Agricultural and Food Chemistry, 58(14), 8139-8144.
https://doi.org/10.1021/jf1005935
Falcone Ferreyra, M. L., Rius, S. P., & Casati, P. (2012). Flavonoids: biosynthesis, biological
functions, and biotechnological applications. Frontiers in Plant Science, 3, 222. https://doi.org/10.3389/fpls.2012.00222
Ferreira, K., de Oliveira, M. T., & Gurgel, E. P. (2024). The potential of plant tissue cultures to improve the steviol glycoside profile of Stevia rebaudiana Bertoni. International Journal of Molecular Sciences, 25(24), 13584. https://doi.org/10.3390/ijms252413584
Gantait, S., Mitra, M., & Mandal, N. (2020). Micropropagation of Stevia rebaudiana plants.
Ciencia Rural, 50, e20181029. https://doi.org/10.1590/0103-8478cr20181029
Garcia-Ochoa, F., & Gomez, E. (2025). Integral forms of the Pirt and Luedeking-Piret models: Simple and accurate tools for bioprocess simulation. Authorea Preprints. https://doi.org/10.22541/au.174394998.87153798/v1
Garcia-Perez, P., & Lozano-Milo, E. (2021). Synthesis and production of steviol glycosides:
recent research trends and perspectives. Applied Microbiology and Biotechnology,
105, 35-50. https://doi.org/10.1007/s00253-021-11306-x
García-Pérez, P., & Lozano-Milo, E. (2021). Synthesis and production of steviol glycosides:
recent research trends and perspectives. Applied Microbiology and Biotechnology,
105, 35-50. https://doi.org/10.1007/s00253-021-11306-x
García-Pérez, P., Lozano-Milo, E., et al. (2023). Modeling the growth kinetics of cell suspensions of Randia echinocarpa and characterization of their bioactive compounds.
Plant Cell, Tissue and Organ Culture, 155, 1-15. https://doi.org/10.1007/s11240-023-02599-z
Georgiev, M. I., Weber, J., & MacIuk, A. (2014). Modeling of plant in vitro cultures: Overview and estimation of biotechnological processes. Biotechnology and Bioengineering, 111, 23-32. https://doi.org/10.1002/bit.25346
Ghazal, B., Fareed, A., Ahmad, N., et al. (2024). Elicitors directed in vitro growth and production of stevioside and other secondary metabolites in Stevia rebaudiana. Scientific
Reports, 14, 65483. https://doi.org/10.1038/s41598-024-65483-6102
Giménez, B., Sanabria, M. E., & Salas, J. E. (2020). Efecto del cultivo en dos pisos altitudinales sobre la síntesis de metabolitos secundarios en hojas de Stevia rebaudiana
Bertoni. Ciencia y Desarrollo, 23(2). https://doi.org/10.21503/cyd.v23i2.2092
Gjureci, B., Todorovska, M., Petreska Stanoeva, J., Tusevski, O., & Gadzovska Simic, S.
(2025). Elicitation of Hypericum perforatum L. hairy root cultures with salicylic acid
and jasmonic acid enhances the production of phenolic compounds and naphthodianthrones with biological activities. Plant Cell, Tissue and Organ Culture. https://doi.org/10.1007/s11240-025-03005-6
Golkar, P., Moradi, M., & Garousi, G. A. (2018). Elicitation of stevia glycosides using salicylic acid and silver nanoparticles under callus culture. Sugar Tech, 21, 569-577.
https://doi.org/10.1007/s12355-018-0655-6
Gómez-Velázquez, H. D. J., Aparicio-Fernández, X., & Reynoso-Camacho, R. (2021). Chia
sprouts elicitation with salicylic acid and hydrogen peroxide to improve their phenolic content, antioxidant capacities in vitro and the antioxidant status in obese rats.
Plant Foods for Human Nutrition, 76, 350-356. https://doi.org/10.1007/s11130-021-00912-9
Hassan, D., et al. (2025). Effect of biofabricated zinc oxide nanoparticles on callus and in
vitro regenerated shoots of extitReseda lutea. Biotechnology. https://doi.org/10.1080/15592324.2025.2558871
Hidalgo, D., et al. (2021). Engineering considerations to produce bioactive compounds from
plant cell suspension culture in bioreactors. Plants, 10, 2762. https://doi.org/10.3390/plants10122762
Hussain, A., Qarshi, I. A., Nazir, H., & Ullah, I. (2012). Plant tissue culture: current status
and opportunities. IntechOpen. https://doi.org/10.5772/50568
Javed, R., Yucesan, B., Zia, M., & Gurel, E. (2017a). CuO nanoparticles significantly influence in vitro culture of Stevia rebaudiana. Plant Cell Tissue and Organ Culture, 133,
1-8. https://doi.org/10.1007/s11240-017-1312-6
Javed, R., Yucesan, B., Zia, M., & Gurel, E. (2017b). Differential effects of plant growth
regulators on physiology and antioxidant capacity in Stevia rebaudiana. Biologia, 72,
1167-1174. https://doi.org/10.1515/biolog-2017-0133
Jiménez Sánchez, K. R., Mercado Luna, A., Feregrino-Pérez, A. A., García Trejo, J. F., Chá-
vez Servín, J. L., & Hernández Maldonado, R. (2021). Effect of nutrient solution
concentration on phenology, stevioside content, total phenolic compounds and total
flavonoids in leaves of Stevia rebaudiana Bertoni. Emirates Journal of Food and
Agriculture, 33(3). https://doi.org/10.9755/ejfa.2021.v33.i3.2666
Kang, K., Park, S., Natsagdorj, U., Kim, Y.-S., & Back, K. (2011). Methanol is an endogenous elicitor molecule for the synthesis of tryptophan and tryptophan-derived secon103
dary metabolites upon senescence of detached rice leaves. The Plant Journal, 66(3),
247-257. https://doi.org/10.1111/j.1365-313X.2011.04486.x
Karaköse, H., Jaiswal, R., & Kuhnert, N. (2011). Characterization and quantification of
hydroxycinnamate derivatives in Stevia rebaudiana leaves by LC-MSn. Journal of
Agricultural and Food Chemistry, 59(19), 10143-10150. https://doi.org/10.1021/jf202185m
Katsumoto, Y., Fukuchi-Mizutani, M., Fukui, Y., Brugliera, F., Holton, T. A., Karan, M.,
Nakamura, N., Yonekura-Sakakibara, K., Togami, J., Pigeaire, A., Tao, G.-Q., Nehra,
N. S., Lu, C.-Y., Dyson, B. K., Tsuda, S., Ashikari, T., Kusumi, T., Mason, J. G., & Tanaka, Y. (2007). Engineering of the rose flavonoid biosynthetic pathway successfully
generated blue-hued flowers accumulating delphinidin. Plant and Cell Physiology,
48, 1589-1600. https://doi.org/10.1093/pcp/pcm131
Kazmi, A., Khan, M., & Mohammad, S. (2019). Elicitation directed growth and production
of steviol glycosides in adventitious roots of Stevia rebaudiana. Industrial Crops and
Products, 139, 111530. https://doi.org/10.1016/J.INDCROP.2019.111530
Khan, M., Ali, A., & Mohammad, S. (2020). Iron nano modulated growth and biosynthesis
of steviol glycosides in Stevia rebaudiana. Plant Cell Tissue and Organ Culture, 144,
1-8. https://doi.org/10.1007/s11240-020-01902-6
Kim, S.-H., et al. (2024). Methyl jasmonate and salicylic acid enhance the total flavonoid,
phenolics, and cannabidiol contents of extitCannabis sativa. Plant Cell Tissue and
Organ Culture, 158, 1-12. https://doi.org/10.1007/s11240-024-02909-z
Kim, Y.-J., et al. (2024). Influence of culture conditions on growth and daidzein and genistein
production in hairy root cultures of Pueraria candollei. Horticulturae, 10, 788. https://doi.org/10.3390/horticulturae10080788
Kwon, I.-B., Park, J.-M., & Choi, Y.-C. (1999). Kinetic model of cell growth and secondary
metabolite synthesis in plant cell culture of Thalictrum rugosum. Biotechnology and
Bioprocess Engineering, 4, 103-108. https://doi.org/10.1007/bf02932383
Liopa-Tsakalidi, A. (2012). Effect of salicylic acid and gibberellic acid pre-soaking on seed
germination of stevia under salt stress. Journal of Medicinal Plants Research, 5, 11.
https://doi.org/10.5897/jmpr11.1106
Luedeking, R., & Piret, E. L. (1959). A kinetic study of the lactic acid fermentation. Batch
process at controlled pH. Journal of Biochemical and Microbiological Technology
and Engineering, 1, 393-412. https://doi.org/10.1002/jbm.540010406
Mala, M., Norrizah, J. S., & Azani, S. (2021). In vitro seed germination and elicitation of
phenolics and flavonoids in in vitro germinated Trigonella foenum graecum plantlets.
Biocatalysis and Agricultural Biotechnology, 35, 101907. https://doi.org/10.1016/j.bcab.2021.101907104
Martínez, M. E., Poirrier, P., Prüfer, D., Schulze Gronover, C., Jorquera, L., Ferrer, P., Díaz,
K., & Chamy, R. (2018). Kinetics and modeling of cell growth for potential anthocyanin induction in cultures of Taraxacum officinale G.H. Weber ex Wiggers (Dandelion)
in vitro. Electronic Journal of Biotechnology, 36, 15-23. https://doi.org/10.1016/j.ejbt.2018.08.006
Mathur, S., & Shekhawat, G. S. (2012). Establishment and characterization of Stevia rebaudiana cell suspension culture: an in vitro approach for production of stevioside. Acta
Physiologiae Plantarum, 35, 1-8. https://doi.org/10.1007/s11738-012-1136-2
Meyer, P., Heidemann, I., Forkmann, G., & Saedler, H. (1987). A new petunia flower colour
generated by transformation of a mutant with a maize gene. Nature, 330, 677-678.
https://doi.org/10.1038/330677a0
Meza Monteverde, N., & Meza Palomino, E. (2019). Estadística aplicada a la investigación
científica. Editorial San Marcos.
Mo, Y., Nagel, C., & Taylor, L. P. (1992). Biochemical complementation of chalcone synthase mutants defines a role for flavonols in functional pollen. Proceedings of the National Academy of Sciences, 89, 7213-7217. https://doi.org/10.1073/pnas.89.15.7213
Moharramnejad, S., Taheri Azam, A., Panahandeh, J., Dehghanian, Z., & Ashraf, M. (2019).
Effect of methyl jasmonate and salicylic acid on in vitro growth, stevioside production, and oxidative defense system in Stevia rebaudiana. Sugar Tech, 22(4), 614-620.
https://doi.org/10.1007/s12355-019-00727-8
Monteiro, W. R., Castro, M. d. M., Mazzoni-Viveiros, S. C., & Mahlberg, P. G. (2001). Development and some histochemical aspects of foliar glandular trichomes of Stevia
rebaudiana (Bert.) Bert. Asteraceae. Revista Brasileira de Botânica, 24(3), 323-332.
https://doi.org/10.1590/s0100-84042001000300013
Montgomery, D. C. (2017). Design and Analysis of Experiments (9.a ed.). John Wiley &
Sons.
Murashige, T., & Skoog, F. (1962). A revised medium for rapid growth and bioassays with
tobacco tissue cultures. Physiologia Plantarum, 15(3), 473-497. https://doi.org/10.1111/j.1399-3054.1962.tb08052.x
Naeem, M., Haider, M. Z., Iftikhar, A., et al. (2022). Root cultures, a boon for the production
of valuable compounds: a comparative review. Plants, 11, 439. https://doi.org/10.3390/plants11030439
Nartop, P. (2018). Engineering of Biomass Accumulation and Secondary Metabolite Production in Plant Cell and Tissue Cultures. En Biotechnology in Agriculture and Food
Processing. Elsevier. https://doi.org/10.1016/b978-0-12-812689-9.00009-1105
Naz, B., Afzal, A., Ali, H., & Ahmad, N. (2024). Melatonin-induced stress enhanced biomass
and secondary metabolites in Stevia rebaudiana. ACS Omega, 9, 1-10. https://doi.org/10.1021/acsomega.3c07404
Ochoa-Villarreal, M., et al. (2025). Comprehensive study of a novel Catharanthus roseus
cell line for medicinal alkaloids production. Bioprocess and Biosystems Engineering.
https://doi.org/10.1007/s00449-025-03270-x
Othman, H. S., & Zainuddin, Z. (2022). Development of Stevia rebaudiana hybrids through
Trigona-assisted pollination. Sains Malaysiana, 51(7). https://doi.org/10.17576/jsm-2022-5107-06
Ozturk, M., et al. (2024). In vitro shoot multiplication of extitHaplophyllum virgatum and
flavonoid elicitation in proliferated shoots by methyl jasmonate. Plant Cell Tissue
and Organ Culture, 156, 1-10. https://doi.org/10.1007/s11240-024-02804-7
Pairazamán-García, J., & Ríos-Caro, T. (2020). In vitro inhibitory effect of Stevia rebaudiana
ethanolic extract on the cariogenic virulence factors of Streptococcus mutans ATCC
25175. Agro Industrial Science, 10(1). https://doi.org/10.17268/agroind.sci.2020.01.13
Palazon, J., et al. (2023). The advent of plant cells in bioreactors. Frontiers in Plant Science,
14, 1310405. https://doi.org/10.3389/fpls.2023.1310405
Pan, Y., Xu, D., Xiao, S., & Chen, Z. (2025). Cell growth kinetics and accumulation of secondary metabolite of Bletilla striata using cell suspension culture. Industrial Crops
and Products, 225, 120997. https://doi.org/10.1016/j.indcrop.2025.120997
Pande, S., & Khetmalas, M. (2011). Biological effect of gamma irradiations on Stevia rebaudiana. World Wide Journals. https://doi.org/10.15373/2249555x/nov2011/3
Pandey, P., & Srivastava, P. (2023). Bioreactor systems for micropropagation of plants: present scenario and future prospects. Frontiers in Plant Science, 14, 1159588. https://doi.org/10.3389/fpls.2023.1159588
Papaefthimiou, M., Kontou, P. I., Bagos, P. G., & Braliou, G. G. (2024). Integration of Antioxidant Activity Assays Data of Stevia Leaf Extracts: A Systematic Review and
Meta-Analysis. Antioxidants, 13(6), 692. https://doi.org/10.3390/antiox13060692
Paucar, K., Tufinio Miranda, K., Ames Canchaya, H., Vergara Sotomayor, A., & Fukusaki
Yoshizawa, A. (2021). Determinación de la actividad antioxidante de extractos de
hojas de Buddleja inkana, Oreocallis grandiflora y Chuquiraga spinosa. Revista de
la Sociedad Química del Perú, 87(2). https://doi.org/10.37761/rsqp.v87i2.343
Perez-Alonso, N., Wilken, D., & Gerber, A. (2021). Temporary immersion system for production of biomass and bioactive compounds from medicinal plants. Agronomy, 11,
2414. https://doi.org/10.3390/agronomy11122414106
Pérez-Alonso, N., Wilken, D., & Gerber, A. (2021). Temporary immersion system for production of biomass and bioactive compounds from medicinal plants. Agronomy, 11,
2414. https://doi.org/10.3390/agronomy11122414
Quispe, J., Castillo, R., & Paredes, D. (2023). Produccion de metabolitos secundarios en cultivos in vitro de plantas medicinales peruanas: revision. Revista Peruana de Biologia,
30(2), e24582. https://doi.org/10.15381/rpb.v30i2.24582
Radi’c, S., Vuj ci’c, V., & Glogo ski, M. (2016). Influence of pH and plant growth regulators
on secondary metabolite production of Stevia rebaudiana. Periodicum Biologorum,
118, 345-350. https://doi.org/10.18054/PB.2016.118.1.3420
Rakhmetov, D., et al. (2016). Introduction of Stevia rebaudiana plants in Ukraine. Zenodo.
https://doi.org/10.5281/zenodo.2333352
Ramirez-Estrada, K., Vidal-Limon, H., Hidalgo, D., Moyano, E., Golenioski, J., & Palazon,
J. (2016). Elicitation, an effective strategy for the biotechnological production of bioactive high-added value compounds in plant cell factories. Molecules, 21, 182. https://doi.org/10.3390/molecules21020182
Rasoli, F., & Gholipoor, M. (2023). Interactive effects of salicylic acid and jasmonic acid
on secondary metabolite production in Echinacea purpurea. International Journal of
Secondary Metabolite, 10(3). https://doi.org/10.21448/ijsm.1079812
Reis, R. V., Guidolin, A. F., & Rodrigues, M. (2020). Stevia rebaudiana Bertoni, a source of
high-potency natural sweetener: biochemical and genetic characterization. Molecules,
25(4), 767. https://doi.org/10.3390/molecules25040767
Rosli, N. A., et al. (2025). Steviol glycoside production and growth in extitStevia rebaudiana
shoot culture after methyl jasmonate elicitation. Journal of Science and Mathematics,
54(4). https://doi.org/10.17576/jsm-2025-5404-03
Roy, A., Khan, A., Ahmad, I., Alghamdi, S., Rajab, B. S., Babalghith, A. O., Alshahrani,
M. Y., Islam, S., & Islam, M. R. (2022). Flavonoids a bioactive compound from medicinal plants and its therapeutic applications. BioMed Research International, 2022,
5445291. https://doi.org/10.1155/2022/5445291
Roy Chowdhury, M., Mehmet, M., Mukherjee, J., Debnath, A. J., & Raná, K. (2025). Chitosan as an elicitor in plant tissue cultures: methodological challenges. Molecules, 30,
173476. https://doi.org/10.3390/molecules30173476
Schlatmann, J. E., ten Hoopen, H. J. G., & Heijnen, J. J. (2000). Large-Scale Production
of Secondary Metabolites by Plant Cell Cultures. En Plant Cell Culture Secondary
Metabolites. CRC Press. https://doi.org/10.1201/9780138743208-2
Silva, L. P., et al. (2013). Optimizing a culture medium for biomass and phenolic compounds production using Ganoderma lucidum. Brazilian Journal of Microbiology,
44, 897-903. https://doi.org/10.1590/s1517-83822013005000032107
Simoni, S., Vangelisti, A., Clemente, C., Usai, G., Santin, M., Ventimiglia, M., Mascagni, F., Natali, L., Angelini, L. G., Cavallini, A., Tavarini, S., & Giordani, T. (2024).
Transcriptomic analyses reveal insights into the shared regulatory network of phenolic compounds and steviol glycosides in Stevia rebaudiana. International Journal of
Molecular Sciences, 25(4), 2136. https://doi.org/10.3390/ijms25042136
Singh, G., et al. (2024). Indirect organogenesis of extitCalendula officinalis L. and comparative phytochemical studies. Agronomy, 14, 1743. https://doi.org/10.3390/agronomy14081743
Sood, H., et al. (2021). Initiation, growth, and development of embryogenic calli of stevia.
Biotecnologia Vegetal, 89, 1-8. https://doi.org/10.22302/iribb.jur.mp.v89i2.458
Soto-Vásquez, M. R. (2015). Metabolitos secundarios, cuantificación de fenoles y flavonoides totales de extractos etanólicos de propóleos de tres localidades del Perú. In Crescendo, 6(2). https://doi.org/10.21895/incres.2015.v6n2.03
Stracke, R., Ishihara, H., Huep, G., Barsch, A., Mehrtens, F., Niehaus, K., & Weisshaar, B.
(2007). Differential regulation of closely related R2R3-MYB transcription factors
controls flavonol accumulation in different parts of the Arabidopsis thaliana seedling.
Plant Journal, 50, 660-677. https://doi.org/10.1111/j.1365-313X.2007.03082.x
Suárez-Rebaza, L. A., Ganoza-Yupanqui, M. L., Zavala, E., & Alva-Plasencia, P. M. (2019).
Phenolic compounds and antioxidant activity of hydroalcoholic and aqueous extracts
of Prosopis pallida “algarrobo”. Agro Industrial Science, 9(1). https://doi.org/10.17268/agroind.sci.2019.01.11
Subrahmanyeswari, T., & Gantait, S. (2024). Identification of stevia lines with enhanced steviol glycosides from gamma ray mutagenesis. Plant Cell Tissue and Organ Culture,
156, 1-10. https://doi.org/10.1007/s11240-024-02892-5
Verduzco, A., Groff, C., Kuchen, B., Gil, R., Fernández, C., & Scaglia, G. (2023). Application of the Luedeking and Piret with delay time model in bioproductions with nonzero kinetic parameters. IEEE Latin America Transactions, 21, 1089-1096. https://doi.org/10.1109/tla.2023.10246344
Weathers, P. J., Towler, M. J., & Jijakli, H. (2021). Plant cell culture as a source of bioactive
small molecules. Biotechnology Advances. https://doi.org/10.1016/j.biotechadv.2021.107774
Wenda, Y., Wowor, P. M., & Leman, M. A. (2017). Uji daya hambat ekstrak daun stevia
(Stevia rebaudiana Bertoni M.) terhadap pertumbuhan Staphylococcus aureus secara
in vitro. e-GiGi, 5(1). https://doi.org/10.35790/eg.5.1.2017.15416
Wijayanti, E. T., Kusuma, D. Y., Kristanti, A. N., Wibowo, A. T., Sugiharto, Sugiarso, D., &
Manuhara, Y. S. W. (2024). Methyl jasmonate elicitation enhanced biomass, phenolic,
and flavonoid production of adventitious root culture of extitGynura procumbens in108
balloon type bubble bioreactor. Majalah Obat Tradisional, 29(2), 162-172. https://doi.org/10.22146/mot.87736
Zhao, J., Davis, L. C., & Verpoorte, R. (2005). Elicitor signal transduction leading to production of plant secondary metabolites. Biotechnology Advances, 23(4), 283-333. https://doi.org/10.1016/j.biotechadv.2005.01.003`;
// Extract proper DOIs
const doiRegex = /10\.\d{4,9}\/[-._;()/:a-zA-Z0-9]+/g;
const doisToFetch = new Set();
let doisMatch;
while ((doisMatch = doiRegex.exec(referencesText)) !== null) {
let doi = doisMatch[0].replace(/\.$/, '');
doisToFetch.add(doi);
}
const dois = Array.from(doisToFetch);
const downloaded = [];
const notDownloaded = [];
const mirrors = ['https://sci-hub.st', 'https://sci-hub.ru', 'https://sci-hub.se', 'https://sci-hub.ee'];
async function downloadPDF(doi) {
for (const mirror of mirrors) {
try {
const url = `${mirror}/${doi}`;
const resHtml = await fetch(url, {
headers: {
'User-Agent': 'Mozilla/5.0 (Windows NT 10.0; Win64; x64) AppleWebKit/537.36 (KHTML, like Gecko) Chrome/114.0.0.0 Safari/537.36'
},
signal: AbortSignal.timeout(10000)
}).then(r => r.text());
const srcRegex = /<iframe[^>]+src=(["'])(.*?)\1|<embed[^>]+src=(["'])(.*?)\3/i;
const match = resHtml.match(srcRegex);
let pdfUrl = null;
if (match) {
pdfUrl = match[2] || match[4];
} else {
const btnRegex = /onclick="location\.href='(.*?)'"/i;
const btnMatch = resHtml.match(btnRegex);
if (btnMatch) pdfUrl = btnMatch[1];
}
if (!pdfUrl) continue;
if (pdfUrl.startsWith('//')) {
pdfUrl = 'https:' + pdfUrl;
} else if (pdfUrl.startsWith('/')) {
pdfUrl = mirror + pdfUrl;
}
const pdfRes = await fetch(pdfUrl, {
headers: {
'User-Agent': 'Mozilla/5.0'
},
signal: AbortSignal.timeout(20000)
});
if (!pdfRes.ok) continue;
const buffer = await pdfRes.arrayBuffer();
if (buffer.byteLength < 5000) continue;
const safeFilename = doi.replace(/[^a-z0-9]/gi, '_').substring(0, 100) + '.pdf';
const dest = path.join(targetDir, safeFilename);
await fs.writeFile(dest, Buffer.from(buffer));
return true;
} catch (err) {
console.error(`Mirror ${mirror} failed for DOI ${doi}:`, err.message);
}
}
return false;
}
async function run() {
for (const doi of dois) {
process.stdout.write(`Downloading ${doi}... `);
const success = await downloadPDF(doi);
if (success) {
downloaded.push(doi);
console.log('OK');
} else {
notDownloaded.push(doi);
console.log('FAILED');
}
// Delay to prevent rate limiting
await new Promise(r => setTimeout(r, 1000));
}
let report = '# Informe de Descarga de Artículos\n\n';
report += '## DOIs Descargados\n\n';
downloaded.forEach(d => report += `- ${d}\n`);
report += '\n## DOIs No Descargados\n\n';
notDownloaded.forEach(d => report += `- ${d}\n`);
report += '\n## Referencias (APA 7)\n\n';
report += referencesText.replace(/\n(?!\n)/g, ' \n');
await fs.writeFile(path.join(targetDir, 'informe.md'), report);
console.log('Report generated at ' + path.join(targetDir, 'informe.md'));
}
run();