| [ |
| { |
| "id": "hard_0385_superoxide_dismutase", |
| "name": "hard_0385_superoxide_dismutase", |
| "text": "Belongs to the iron/manganese superoxide dismutase family.Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.Homodimer.2 superoxide + 2 H(+) = H2O2 + O2.Binds 1 Mn(2+) ion per subunit.Although found extracellularly, no signal sequence is present. An alternative secretory pathway may be used.", |
| "protein": "MAIILPELPYAYDALEPQFDAETMTLHHDKHHATYVANTDAALEKHPEIGENLEELLADVPKIPEDIRQALINNGGGHLNHALFWELLSPEKQDVTPDVAQAIDDAFGSFDAFKEQFTAAATGRFGSGWAWLVVNKEGQLEITSTANQDTPISEGKKPILALDVWEHAYYLNYRNVRPNYIKAFFEIINWKKVSALYQAAK", |
| "generatedProtein": "MAIILPELPYAYDALEPHIDAETMTLHHDKHHATYVANTNAALEKHPEIGENLEELLADVTKIPEDIRQALINNGGGHLNHALFWELLSPEKQDVTPDVAQAIDDAFGSFDAFKEQFTAAATGRFGSGWAWLVVNKEGQLEITSTANQDTPISEGKKPILALDVWEHAYYLNYRNVRPNYIKAFFEIINWKKVSELYQAAK", |
| "generatedText": "Belongs to the iron/manganese superoxide dismutase family.Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.Homodimer.2 H(+) + 2 superoxide = H2O2 + O2.Binds 1 Mn(2+) ion per subunit.Although found extracellularly, no signal sequence is present. An alternative secretory pathway may be used.", |
| "mode": "Precomputed · large-v5", |
| "note": "Two independent directions: reference text → generated sequence; reference sequence → generated text. These are not round-trip outputs." |
| }, |
| { |
| "id": "hard_0313_capsule_biosynthesis", |
| "name": "hard_0313_capsule_biosynthesis", |
| "text": "Belongs to the CpsC/CapA family.Required for CpsD phosphorylation (By similarity). Involved in the regulation of capsular polysaccharide biosynthesis. May be part of a complex that directs the coordinated polymerization and export to the cell surface of the capsular polysaccharide.Capsule biogenesis; capsule polysaccharide biosynthesis.", |
| "protein": "MNKIANTEVEINIFNLLKKLWKKKFLITFVAIAFATAGLFYSLFIVTPQYTSSTRIYVINPNTPNNSITAQDLQAGSFLANDYKEIITSTDVLEKVISSEKLNYPSSQLLQKITVSILKDTRVISISVEDANPKMSQKLANSVREAAVSKIKAVTQVEDITTLEKGNLPKAPSSPNIKKNVLIGFIVGAGLSTIVLVIMGILDDRVNTEEDIEKALGLTSLGIVPDLNKL", |
| "generatedProtein": "MNKIANTEVEINIFNLLKKLWKKKFLITFVAIAFATAGLFYSLFIVTPQYTSSTRIYVINPNTPNNSITAQDLQAGSFLANDYKEIITSTDVLEKVISSEKLNYPSSQLLQKITVSILKDTRVISISVEDANPKMSQKLANSVREAAVSKIKAVTQVEDITTLEKGNLPKAPSSPNIKKNVLIGFIVGAGLSTIVLVIMGILDDRVNTEEDIEKVLGLTSLGIVPDLNKL", |
| "generatedText": "Belongs to the CpsC/CapA family.Required for CpsD phosphorylation. Involved in the regulation of capsular polysaccharide biosynthesis. May be part of a complex that directs the coordinated polymerization and export to the cell surface of the capsular polysaccharide (By similarity).Capsule biogenesis; capsule polysaccharide biosynthesis.", |
| "mode": "Precomputed · large-v5", |
| "note": "Two independent directions: reference text → generated sequence; reference sequence → generated text. These are not round-trip outputs." |
| }, |
| { |
| "id": "hard_0232_kallikrein_protease", |
| "name": "hard_0232_kallikrein_protease", |
| "text": "Belongs to the peptidase S1 family. Kallikrein subfamily.Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.Prorenin-converting enzyme cleaves mouse REN-2 prorenin at a dibasic site to yield mature renin.Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.", |
| "protein": "MWFLILFPALSLGGIDAAPPLQSRVVGGFNCEKNSQPWQVAVYYQKEHICGGVLLDRNWVLTAAHCYVDQYEVWLGKNKLFQEEPSAQHRLVSKSFPHPGFNMSLLMLQTTPPGADFSNDLMLLRLSKPADITDVVKPIALPTKEPKPGSTCLASGWGSITPTRWQKSDDLQCVFITLLPNENCAKVYLQKVTDVMLCAGEMGGGKDTCAGDSGGPLICDGILQGTTSNGPEPCGKPGVPAIYTNLIKFNSWIKDTMMKNA", |
| "generatedProtein": "MWFLILFLALSLGGIDAAPPVQSRIVGGFNCEKNSQPWHVAVYRYNKYICGGVLLDPSWVITAAHCYSNKYNVWLGKNNLFQREPSAQHRLVSKSFPHPDYNMSLLNDHTPQPEDDYSNDLMLLRLSEPADITDAVKPIALPTEEPKLGSTCLASGWGSITPTKWQKPDDLQCVNIKLLPNENCAKAHIEKVTDVMLCAGEMDGGKDTCKGDSGGPLICDGVLQGITSWGSTPCGKPNKPGIYTKLIKFTSWIKDTMAKNP", |
| "generatedText": "Belongs to the peptidase S1 family. Kallikrein subfamily.Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.", |
| "mode": "Precomputed · large-v5", |
| "note": "Two independent directions: reference text → generated sequence; reference sequence → generated text. These are not round-trip outputs." |
| }, |
| { |
| "id": "hard_0490_fetal_hemoglobin", |
| "name": "hard_0490_fetal_hemoglobin", |
| "text": "Belongs to the globin family.Gamma chains make up the fetal hemoglobin F, in combination with alpha chains.Heterotetramer of two alpha chains and two gamma chains in fetal hemoglobin (Hb F).Red blood cells.", |
| "protein": "MGHFTEEDKATITSLWGKVNVEDVGGETLGRLLVVYPWTQRFFDSFGNLSSASAIMGNPKVKAHGKKVLTSLGGAIKNLDDLKGTFAQLSELHCDKLHVDPENFRLLGNVLVTVLAIHFGKEFTPEVQASWQKMVAGVASALSSRYH", |
| "generatedProtein": "MGHFTEEDKATITSLWGKVNVEDAGGETLGRLLVVYPWTQRFFDSFGNLSSASAIMGNPKVKAHGKKVLTSLGDAIKNLDDLKGTFAQLSELHCDKLHVDPENFRLLGNVLVTVLAIHFGKEFTPEVQASWQKMVTGVASALSSRYH", |
| "generatedText": "Belongs to the globin family.Gamma chains make up the fetal hemoglobin F, in combination with alpha chains.Heterotetramer of two alpha chains and two gamma chains in fetal hemoglobin (Hb F).Red blood cells.", |
| "mode": "Precomputed · large-v5", |
| "note": "Two independent directions: reference text → generated sequence; reference sequence → generated text. These are not round-trip outputs." |
| }, |
| { |
| "id": "hard_0476_ribosomal_protein_us4", |
| "name": "hard_0476_ribosomal_protein_us4", |
| "text": "Belongs to the universal ribosomal protein uS4 family.One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.With S5 and S12 plays an important role in translational accuracy.Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity (By similarity).", |
| "protein": "MSRYRGPRLKKIRRLGALPGLTRKTPKSGSNLKKKFHSGKKEQYRIRLQEKQKLRFHYGLTERQLLRYVHIAGKAKRSTGQVLLQLLEMRLDNILFRLGMASTIPGARQLVNHRHILVNGRIVNIPSFRCKPRDIITTKDNQRSKGLVQTLMASSDPGKLPKHLTIDTLEYKGLVNKILDRKWVGLKINELLVVEYYSRQT", |
| "generatedProtein": "MSRYRGPRLKKIRRLGALPGLTRKTPKSGSNLKKKFHSGKKEQYRIRLQEKQKLRFHYGLTERQLLRYVHIAGKAKRSTGQVLLQLLEMRLDNILFRLGMASTIPGARQLVNHRHILVNGRIVDIPSFRCKPRDIITTKDNQRSKRLVQNSIASSDPGKLPKHLTIDTLQYKGLVKKILDRKWVGLKINELLVVEY", |
| "generatedText": "Belongs to the universal ribosomal protein uS4 family.One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.With S5 and S12 plays an important role in translational accuracy.Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity (By similarity).", |
| "mode": "Precomputed · large-v5", |
| "note": "Two independent directions: reference text → generated sequence; reference sequence → generated text. These are not round-trip outputs." |
| }, |
| { |
| "id": "hard_0479_mitochondrial_complex_i", |
| "name": "hard_0479_mitochondrial_complex_i", |
| "text": "Belongs to the complex I NDUFB8 subunit family.Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.Complex I is composed of 45 different subunits.", |
| "protein": "MAVARAGVLGVQWLQRASWNVMPLGARTASHMTKDMFPGPYPRTPEERAAAAKKYNMRVEDYEPYPDDGMGYGDYPKLPDRSQHERDPWYSWDQPDLRLNWGEPMHWHLDMFNRNRVDTSPILVSWNVMCMQLFGFLAFMIFMCWVGEVYPVYQPVGPKQYPYNNLYLERGGDPSKEPERVVHYEI", |
| "generatedProtein": "MAAARAGVLGVQWLQRASRNVVPLGARTASHMTKDMFPGPYPRTPEERAAAAKKYNMRVEDYEPYPDDGMGYGDYPKLPDRSQHERDPWYSWDQPGLRLNWGEPMHWHLDMYNRNRVDTSPTPVSWHVMCMQLFGFLAFMIFMCWVGDVYPVYQPVGPKQYPYNNLYLERGGDPSKEPERVVHYEI", |
| "generatedText": "Belongs to the complex I NDUFB8 subunit family.Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.Complex I is composed of 45 different subunits.", |
| "mode": "Precomputed · large-v5", |
| "note": "Two independent directions: reference text → generated sequence; reference sequence → generated text. These are not round-trip outputs." |
| }, |
| { |
| "id": "hard_0497_calmodulin", |
| "name": "hard_0497_calmodulin", |
| "text": "Belongs to the calmodulin family.Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.This protein has four functional calcium-binding sites.", |
| "protein": "MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGFISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVKMMTSK", |
| "generatedProtein": "MADQLTDDQISEFKEAFSLFDKDGDGCITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLNLMARKMKDTDSEEELKEAFRVFDKDQNGFISAAELRHVMTNLGEKLTDEEVDEMIREADVDGDGQINYEEFVKVMMAK", |
| "generatedText": "Belongs to the calmodulin family.Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.This protein has four functional calcium-binding sites.", |
| "mode": "Precomputed · large-v5", |
| "note": "Two independent directions: reference text → generated sequence; reference sequence → generated text. These are not round-trip outputs." |
| }, |
| { |
| "id": "hard_0496_neurophysin_oxytocin", |
| "name": "hard_0496_neurophysin_oxytocin", |
| "text": "Belongs to the vasopressin/oxytocin family.Neurophysin 1 specifically binds oxytocin.Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland. Acts by binding to oxytocin receptor (OXTR) (By similarity).Interacts with oxytocin receptor (Ki=1.5 nM) (By similarity). Interacts with vasopressin V1aR/AVPR1A (Ki=37 nM), V1bR/AVPR1B (Ki=222 nM), and V2R/AVPR2 receptors (Ki=823 nM) (By similarity).", |
| "protein": "MAGSSLACCLLGLLALTSACYIQNCPLGGKRAVLDLDVRTCLPCGPGGKGRCFGPSICCGDELGCFVGTAEALRCQEENYLPSPCQSGQKPCGSGGRCAAAGICCSPDGCHEDPACDPEAAFSQH", |
| "generatedProtein": "MAGPSLACCLLGLLALTSACYIQNCPLGGKRAALDLDVRKCLPCGPGGKGRCFGPSICCADELGCFVGTAEALRCQEENYLPSPCQSGQKACGSGGRCAVFGLCCSPDGCRTDPACDPESAFSQR", |
| "generatedText": "Belongs to the vasopressin/oxytocin family.Neurophysin 1 specifically binds oxytocin.Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland. Acts by binding to oxytocin receptor (OXTR) (By similarity).Interacts with oxytocin receptor (Ki=1.5 nM) (By similarity). Interacts with vasopressin V1aR/AVPR1A (Ki=37 nM), V1bR/AVPR1B (Ki=222 nM), and V2R/AVPR2 receptors (Ki=823 nM) (By similarity).", |
| "mode": "Precomputed · large-v5", |
| "note": "Two independent directions: reference text → generated sequence; reference sequence → generated text. These are not round-trip outputs." |
| }, |
| { |
| "id": "hard_0259_is1_transposase", |
| "name": "hard_0259_is1_transposase", |
| "text": "Belongs to the transposase 27 family.Absolutely required for transposition of IS1.Truncated N-terminus.", |
| "protein": "MPGNRPHYGRWPQHDFTSLKKLRPQSVTSRIQPGSDVIVCAEMDEQWGYVGAKSRQRWLFYAYDSLRKTVVAHVFGERTMATLGRLMSLLSPFDVVIWMTDGWPLYESRLKGKLHVISKRYTQRIERHNLNLRQHLARLGRKSLSFSKSVELHDKVIGHYLNIKHYQ", |
| "generatedProtein": "MPGNSPHYGRWPQHDFTSLKKLRPQSVTSRIQPGSDVIVCAEMDEQWGYVGAKSRQRWLFYAYDSLRKTVVAHVFGERTMATLGRLMSLLSPFDVVIWMTDGWPLYESRLKGKLHVISKRYTQRIERHNLNLRQHLARLGRKSLSFSKSVELHDKVIGHYLNIKHYQ", |
| "generatedText": "Belongs to the transposase 27 family.Absolutely required for transposition of IS1.", |
| "mode": "Precomputed · large-v5", |
| "note": "Two independent directions: reference text → generated sequence; reference sequence → generated text. These are not round-trip outputs." |
| }, |
| { |
| "id": "hard_0272_udp_glucose_pyrophosphorylase", |
| "name": "hard_0272_udp_glucose_pyrophosphorylase", |
| "text": "Belongs to the UDPGP type 2 family.alpha-D-glucose 1-phosphate + UTP + H(+) = UDP-alpha-D-glucose + diphosphate.Carbohydrate metabolism; nucleotide-sugar metabolism.", |
| "protein": "MTKVRKAIIPAAGLGTRFLPATKALAKEMLPIVDKPTIQFIVEEALKSGIEEILVVTGKAKRSIEDHFDSNFELEYNLQAKGKNELLKLVDETTAINLHFIRQSHPRGLGDAVLQAKAFVGNEPFVVMLGDDLMDITNASAKPLTKQLMEDYDKTHASTIAVMKVPHEDVSSYGVIAPQGKAVKGLYSVDTFVEKPQPEDAPSDLAIIGRYLLTPEIFGILERQTPGAGNEVQLTDAIDTLNKTQRVFAREFKGNRYDVGDKFGFMKTSIDYALEHPQVKEDLKNYIIKLGKALEKSKVPTHSK", |
| "generatedProtein": "MTKVRKAIIPAAGLGTRFLPATKALAKEMLPIVDKPTIQFIVEEALKSGIEEILVVTGKAKRSIEDHFDSNFELEYNLQAKGKNELLKLVDETTAINLHFIRQSHPRGLGDAVLQAKAFVGNEPFVVMLGDDLMDITNASAKPLTKQLMEDYDKTHASTIAVMKVPHEDVSSYGVIAPQGKAVKGLYSVDTFVEKPQPEDAPSDLAIIGRYLLTPEIFDILERQVPGAGNEVQLTDAIDTLNKTQRVFAREFKGNRYDVGDKFGFMKTSIDYALEHPQVKEDLKNYIIKLGKALEKSKVPTHSK", |
| "generatedText": "Belongs to the UDPGP type 2 family.alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-glucose.Carbohydrate metabolism; nucleotide-sugar metabolism.", |
| "mode": "Precomputed · large-v5", |
| "note": "Two independent directions: reference text → generated sequence; reference sequence → generated text. These are not round-trip outputs." |
| } |
| ] |
|
|
