File size: 10,779 Bytes
7c07ade
 
62d32ab
7c07ade
e35d6b1
62d32ab
7c07ade
 
 
 
 
 
62d32ab
e35d6b1
62d32ab
 
 
 
7c07ade
62d32ab
5c8b030
62d32ab
 
7c07ade
 
 
62d32ab
7c07ade
5c8b030
7c07ade
 
e35d6b1
5c8b030
 
 
 
 
b1310d3
5c8b030
 
b1310d3
 
7c07ade
5c8b030
b1310d3
5c8b030
 
b1310d3
 
5c8b030
 
b1310d3
 
5c8b030
 
 
b1310d3
 
5c8b030
 
 
 
b1310d3
 
5c8b030
 
 
 
b1310d3
 
 
5c8b030
b1310d3
 
 
5c8b030
 
b1310d3
 
 
5c8b030
b1310d3
 
 
 
 
5c8b030
7c07ade
 
5c8b030
e35d6b1
62d32ab
e35d6b1
5c8b030
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
b1310d3
5c8b030
 
 
b1310d3
5c8b030
e35d6b1
 
5c8b030
 
b1310d3
 
 
 
5c8b030
b1310d3
 
 
5c8b030
 
7c07ade
 
 
 
5c8b030
e35d6b1
 
5c8b030
e35d6b1
b1310d3
e35d6b1
5c8b030
 
 
e35d6b1
7ecca95
62d32ab
 
 
e35d6b1
 
 
5c8b030
 
 
 
 
 
 
 
 
 
 
 
 
 
b1310d3
5c8b030
e35d6b1
5c8b030
62d32ab
e35d6b1
 
 
 
b1310d3
e35d6b1
b1310d3
5c8b030
 
b1310d3
 
5c8b030
b1310d3
e35d6b1
5c8b030
7c07ade
b1310d3
 
 
5c8b030
 
b1310d3
5c8b030
 
 
 
 
 
 
b1310d3
 
5c8b030
 
b1310d3
 
5c8b030
b1310d3
 
5c8b030
b1310d3
 
5c8b030
b1310d3
5c8b030
b1310d3
 
5c8b030
 
 
 
b1310d3
e35d6b1
5c8b030
 
b1310d3
5c8b030
 
b1310d3
 
5c8b030
 
 
 
 
b1310d3
 
5c8b030
b1310d3
e35d6b1
5c8b030
 
 
b1310d3
5c8b030
 
 
b1310d3
5c8b030
b1310d3
5c8b030
 
 
 
 
 
e35d6b1
 
 
 
5c8b030
e35d6b1
62d32ab
7c07ade
 
62d32ab
e35d6b1
62d32ab
e35d6b1
 
 
 
62d32ab
 
e35d6b1
62d32ab
e35d6b1
5c8b030
e35d6b1
 
5c8b030
e35d6b1
5c8b030
e35d6b1
5c8b030
 
e35d6b1
 
 
5c8b030
 
 
 
b1310d3
5c8b030
b1310d3
 
5c8b030
 
 
 
 
b1310d3
 
5c8b030
 
 
b1310d3
5c8b030
 
 
 
b1310d3
 
5c8b030
b1310d3
5c8b030
b1310d3
5c8b030
e35d6b1
7c07ade
 
 
5c8b030
7c07ade
5c8b030
 
 
62d32ab
5c8b030
7ecca95
5c8b030
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
200
201
202
203
204
205
206
207
208
209
210
211
212
213
214
215
216
217
218
219
220
221
222
223
224
225
226
227
228
229
230
231
232
233
234
235
236
237
238
239
240
241
242
243
244
245
246
247
248
249
250
251
252
253
254
255
256
257
258
259
260
261
262
263
264
265
266
267
268
269
270
271
272
273
274
275
276
277
278
279
280
281
282
283
284
285
286
287
288
289
290
291
292
293
294
295
296
297
298
299
300
301
302
303
304
305
306
307
308
309
310
311
312
313
314
315
316
317
318
319
320
321
322
323
324
325
326
327
328
329
330
331
332
333
334
335
336
337
338
339
340
341
342
343
344
345
346
347
348
349
350
351
352
353
354
355
356
357
358
359
# Phase 3 Implementation Spec: Judge Vertical Slice

**Goal**: Implement the "Brain" of the agent — evaluating evidence quality.
**Philosophy**: "Structured Output or Bust."
**Estimated Effort**: 3-4 hours
**Prerequisite**: Phase 2 complete

---

## 1. The Slice Definition

This slice covers:
1. **Input**: Question + List of `Evidence`.
2. **Process**:
   - Construct prompt with evidence.
   - Call LLM (PydanticAI).
   - Parse into `JudgeAssessment`.
3. **Output**: `JudgeAssessment` object.

**Files**:
- `src/utils/models.py`: Add Judge models
- `src/prompts/judge.py`: Prompt templates
- `src/agent_factory/judges.py`: Handler logic

---

## 2. Models (`src/utils/models.py`)

Add these to the existing models file:

```python
class DrugCandidate(BaseModel):
    """A potential drug repurposing candidate."""
    drug_name: str = Field(..., description="Name of the drug")
    original_indication: str = Field(..., description="What the drug was originally approved for")
    proposed_indication: str = Field(..., description="The new proposed use")
    mechanism: str = Field(..., description="Proposed mechanism of action")
    evidence_strength: Literal["weak", "moderate", "strong"] = Field(
        ...,
        description="Strength of supporting evidence"
    )

class JudgeAssessment(BaseModel):
    """The judge's assessment of the collected evidence."""
    sufficient: bool = Field(
        ...,
        description="Is there enough evidence to write a report?"
    )
    recommendation: Literal["continue", "synthesize"] = Field(
        ...,
        description="Should we search more or synthesize a report?"
    )
    reasoning: str = Field(
        ...,
        max_length=500,
        description="Explanation of the assessment"
    )
    overall_quality_score: int = Field(
        ...,
        ge=0,
        le=10,
        description="Overall quality of evidence (0-10)"
    )
    coverage_score: int = Field(
        ...,
        ge=0,
        le=10,
        description="How well does evidence cover the query (0-10)"
    )
    candidates: list[DrugCandidate] = Field(
        default_factory=list,
        description="Drug candidates identified in the evidence"
    )
    next_search_queries: list[str] = Field(
        default_factory=list,
        max_length=5,
        description="Suggested follow-up queries if more evidence needed"
    )
    gaps: list[str] = Field(
        default_factory=list,
        description="Information gaps identified in current evidence"
    )
```

---

## 3. Prompts (`src/prompts/judge.py`)

```python
"""Prompt templates for the Judge."""
from typing import List
from src.utils.models import Evidence

JUDGE_SYSTEM_PROMPT = """You are a biomedical research quality assessor specializing in drug repurposing.

Your job is to evaluate evidence retrieved from PubMed and web searches, and decide if:
1. There is SUFFICIENT evidence to write a research report
2. More searching is needed to fill gaps

## Evaluation Criteria

### For "sufficient" = True (ready to synthesize):
- At least 3 relevant pieces of evidence
- At least one peer-reviewed source (PubMed)
- Clear mechanism of action identified
- Drug candidates with at least "moderate" evidence strength

### For "sufficient" = False (continue searching):
- Fewer than 3 relevant pieces
- No clear drug candidates identified
- Major gaps in mechanism understanding
- All evidence is low quality

## Output Requirements
- Be STRICT. Only mark sufficient=True if evidence is genuinely adequate
- Always provide reasoning for your decision
- If continuing, suggest SPECIFIC, ACTIONABLE search queries
- Identify concrete gaps, not vague statements

## Important
- You are assessing DRUG REPURPOSING potential
- Focus on: mechanism of action, existing clinical data, safety profile
- Ignore marketing content or non-scientific sources"""

def format_evidence_for_prompt(evidence_list: List[Evidence]) -> str:
    """Format evidence list into a string for the prompt."""
    if not evidence_list:
        return "NO EVIDENCE COLLECTED YET"

    formatted = []
    for i, ev in enumerate(evidence_list, 1):
        formatted.append(f"""
---
Source: {ev.citation.source.upper()}
Title: {ev.citation.title}
Date: {ev.citation.date}
URL: {ev.citation.url}

Content:
{ev.content[:1500]}
---")

    return "\n".join(formatted)

def build_judge_user_prompt(question: str, evidence: List[Evidence]) -> str:
    """Build the user prompt for the judge."""
    evidence_text = format_evidence_for_prompt(evidence)

    return f"""## Research Question
{question}

## Collected Evidence ({len(evidence)} pieces)
{evidence_text}

## Your Task
Assess the evidence above and provide your structured assessment.
If evidence is insufficient, suggest 2-3 specific follow-up search queries."""
```

---

## 4. Handler (`src/agent_factory/judges.py`)

```python
"""Judge handler - evaluates evidence quality."""
import structlog
from typing import List
from pydantic_ai import Agent
from pydantic_ai.models.openai import OpenAIModel
from pydantic_ai.models.anthropic import AnthropicModel
from tenacity import retry, stop_after_attempt, wait_exponential, retry_if_exception_type

from src.utils.config import settings
from src.utils.exceptions import JudgeError
from src.utils.models import JudgeAssessment, Evidence
from src.prompts.judge import JUDGE_SYSTEM_PROMPT, build_judge_user_prompt

logger = structlog.get_logger()

def get_llm_model():
    """Get the configured LLM model for PydanticAI."""
    if settings.llm_provider == "openai":
        return OpenAIModel(
            settings.llm_model,
            api_key=settings.get_api_key(),
        )
    elif settings.llm_provider == "anthropic":
        return AnthropicModel(
            settings.llm_model,
            api_key=settings.get_api_key(),
        )
    else:
        raise JudgeError(f"Unknown LLM provider: {settings.llm_provider}")

# Initialize Agent
judge_agent = Agent(
    model=get_llm_model(),
    result_type=JudgeAssessment,
    system_prompt=JUDGE_SYSTEM_PROMPT,
)

class JudgeHandler:
    """Handles evidence assessment using LLM."""

    def __init__(self, agent: Agent | None = None):
        """
        Initialize the judge handler.

        Args:
            agent: Optional PydanticAI agent (for testing injection)
        """
        self.agent = agent or judge_agent
        self._call_count = 0

    @retry(
        stop=stop_after_attempt(3),
        wait=wait_exponential(multiplier=1, min=2, max=10),
        retry=retry_if_exception_type((TimeoutError, ConnectionError)),
        reraise=True,
    )
    async def assess(
        self,
        question: str,
        evidence: List[Evidence],
    ) -> JudgeAssessment:
        """
        Assess the quality and sufficiency of evidence.

        Args:
            question: The original research question
            evidence: List of Evidence objects to assess

        Returns:
            JudgeAssessment with decision and recommendations

        Raises:
            JudgeError: If assessment fails after retries
        """
        logger.info(
            "Starting evidence assessment",
            question=question[:100],
            evidence_count=len(evidence),
        )

        self._call_count += 1

        # Build the prompt
        user_prompt = build_judge_user_prompt(question, evidence)

        try:
            # Run the agent - PydanticAI handles structured output
            result = await self.agent.run(user_prompt)

            # result.data is already a JudgeAssessment (typed!)
            assessment = result.data

            logger.info(
                "Assessment complete",
                sufficient=assessment.sufficient,
                recommendation=assessment.recommendation,
                quality_score=assessment.overall_quality_score,
                candidates_found=len(assessment.candidates),
            )

            return assessment

        except Exception as e:
            logger.error("Judge assessment failed", error=str(e))
            raise JudgeError(f"Failed to assess evidence: {e}") from e
            
    async def should_continue(self, assessment: JudgeAssessment) -> bool:
        """
        Decide if the search loop should continue based on the assessment.
        
        Returns:
            True if we should search more, False if we should stop (synthesize or give up).
        """
        return not assessment.sufficient and assessment.recommendation == "continue"

    @property
    def call_count(self) -> int:
        """Number of LLM calls made (for budget tracking)."""
        return self._call_count
```

---

## 5. TDD Workflow

### Test File: `tests/unit/agent_factory/test_judges.py`

```python
"""Unit tests for JudgeHandler."""
import pytest
from unittest.mock import AsyncMock, MagicMock

class TestJudgeHandler:
    @pytest.mark.asyncio
    async def test_assess_returns_assessment(self, mocker):
        from src.agent_factory.judges import JudgeHandler
        from src.utils.models import JudgeAssessment, Evidence, Citation

        # Mock PydanticAI agent result
        mock_result = MagicMock()
        mock_result.data = JudgeAssessment(
            sufficient=True,
            recommendation="synthesize",
            reasoning="Good",
            overall_quality_score=8,
            coverage_score=8
        )
        
        mock_agent = AsyncMock()
        mock_agent.run = AsyncMock(return_value=mock_result)

        handler = JudgeHandler(agent=mock_agent)
        result = await handler.assess("q", [])
        
        assert result.sufficient is True
        
    @pytest.mark.asyncio
    async def test_should_continue(self, mocker):
        from src.agent_factory.judges import JudgeHandler
        from src.utils.models import JudgeAssessment
        
        handler = JudgeHandler(agent=AsyncMock())
        
        # Continue case
        assess1 = JudgeAssessment(
            sufficient=False,
            recommendation="continue",
            reasoning="Need more",
            overall_quality_score=5,
            coverage_score=5
        )
        assert await handler.should_continue(assess1) is True
        
        # Stop case
        assess2 = JudgeAssessment(
            sufficient=True,
            recommendation="synthesize",
            reasoning="Done",
            overall_quality_score=8,
            coverage_score=8
        )
        assert await handler.should_continue(assess2) is False
```

---

## 6. Implementation Checklist

- [ ] Update `src/utils/models.py` with Judge models
- [ ] Create `src/prompts/judge.py`
- [ ] Implement `src/agent_factory/judges.py`
- [ ] Write tests in `tests/unit/agent_factory/test_judges.py`
- [ ] Run `uv run pytest tests/unit/agent_factory/`

```