data/rag/knowledge_base/Corynebacterium/striatum.json

{
  "schema_version": "1.0",
  "level": "species",
  "genus": "Corynebacterium",
  "species": "striatum",

  "overview": {
    "short": "Corynebacterium striatum is a Gram-positive, non-motile rod commonly present as skin flora but increasingly recognized as an opportunistic pathogen.",
    "clinical_context": "Associated with bloodstream, respiratory, and prosthetic device infections."
  },

  "expected_fields": {
    "Gram Stain": "Positive",
    "Shape": "Short Rods",
    "Motility": "Negative",
    "Capsule": "Negative",
    "Spore Formation": "Negative",
    "Haemolysis": "Negative",
    "Haemolysis Type": "None",
    "Media Grown On": [
      "Blood Agar"
    ],
    "Colony Morphology": [
      "White",
      "Grey",
      "Dry"
    ],
    "Oxygen Requirement": "Aerobic",
    "Growth Temperature": "20//37",
    "Catalase": "Positive",
    "Oxidase": "Negative",
    "Indole": "Negative",
    "Urease": "Variable",
    "Citrate": "Negative",
    "Methyl Red": "Unknown",
    "VP": "Unknown",
    "H2S": "Negative",
    "DNase": "Negative",
    "ONPG": "Negative",
    "Coagulase": "Negative",
    "Gelatin Hydrolysis": "Variable",
    "Esculin Hydrolysis": "Variable",
    "Nitrate Reduction": "Variable",
    "NaCl Tolerant (>=6%)": "Variable",
    "Lipase Test": "Variable",
    "Lysine Decarboxylase": "Negative",
    "Ornithine Decarboxylase": "Negative",
    "Ornitihine Decarboxylase": "Negative",
    "Arginine dihydrolase": "Negative",
    "Glucose Fermentation": "Variable",
    "Lactose Fermentation": "Negative",
    "Sucrose Fermentation": "Variable",
    "Maltose Fermentation": "Variable",
    "Mannitol Fermentation": "Variable",
    "Sorbitol Fermentation": "Negative",
    "Xylose Fermentation": "Negative",
    "Rhamnose Fermentation": "Negative",
    "Arabinose Fermentation": "Negative",
    "Raffinose Fermentation": "Negative",
    "Trehalose Fermentation": "Variable",
    "Inositol Fermentation": "Negative",
    "Gas Production": "Negative",
    "TSI Pattern": "Unknown",
    "Colony Pattern": "Unknown",
    "Pigment": "None",
    "Motility Type": "Unknown"
  },

  "species_markers": [
    {
      "field": "Urease",
      "value": "Variable",
      "importance": "medium",
      "notes": "Helps separate from biochemically inert species."
    },
    {
      "field": "Glucose Fermentation",
      "value": "Variable",
      "importance": "medium",
      "notes": "More biochemically active than C. jeikeium."
    }
  ],

  "common_confusions": [
    {
      "species": "Corynebacterium jeikeium",
      "reason": "Overlapping hospital-associated ecology."
    }
  ],

  "when_to_question_identification": [
    "Strong NaCl tolerance favors C. jeikeium.",
    "Complete biochemical inactivity argues against C. striatum."
  ],

  "recommended_next_tests": [
    {
      "test": "API Coryne",
      "reason": "Supports biochemical differentiation."
    },
    {
      "test": "MALDI-TOF MS",
      "reason": "Gold standard for species identification."
    }
  ]
}