Update data/rag/knowledge_base/Comamonas/kerstersii.json

data/rag/knowledge_base/Comamonas/kerstersii.json

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+{
+  "genus": "Comamonas",
+  "species": "kerstersii",
+  "full_name": "Comamonas kerstersii",
+  "clinical_significance": "An emerging human pathogen frequently associated with acute appendicitis and peritonitis. Also reported in bacteremia, pelvic inflammatory disease, and urinary tract infections. Likely underdiagnosed prior to widespread MALDI-TOF use.",
+  "phenotype_profile": {
+    "morphology": "Slender, motile Gram-negative rods with polar flagella.",
+    "culture": "Non-pigmented, smooth colonies on blood agar. NLF on MacConkey. Aerobic growth.",
+    "biochemical": [
+      "Oxidase positive",
+      "Catalase positive",
+      "Non-fermentative",
+      "Nitrate reduction positive",
+      "Indole negative",
+      "Urease negative",
+      "ONPG negative",
+      "Motile"
+    ]
+  },
+  "differentiation": {
+    "from close species": [
+      "More clinically significant than C. testosteronii.",
+      "Often associated with polymicrobial intra-abdominal infections.",
+      "Identified reliably only through MALDI-TOF or sequencing."
+    ],
+    "from other genera": [
+      "No DNase activity (unlike Delftia acidovorans).",
+      "No pigment (unlike some Pseudomonas).",
+      "Non-fermenting profile excludes Enterobacterales."
+    ]
+  },
+  "virulence_factors": [
+    "Adhesion to damaged mucosa",
+    "Biofilm formation (limited evidence)",
+    "Environmental persistence"
+  ],
+  "confirmation_methods": [
+    "MALDI-TOF MS (preferred)",
+    "16S rRNA sequencing",
+    "Biochemical non-fermenter profile"
+  ],
+  "treatment_notes": "Generally susceptible to fluoroquinolones, piperacillin–tazobactam, carbapenems, and TMP-SMX. Resistance remains uncommon but testing required.",
+  "notes": "Most isolates originate from appendiceal abscesses or perforated appendicitis specimens.",
+  "references": [
+    "Comamonas kerstersii infection reports",
+    "Intra-abdominal polymicrobial infection studies"
+  ]
+}