Update data/rag/knowledge_base/Acinetobacter/baumannii.json

data/rag/knowledge_base/Acinetobacter/baumannii.json

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+{
+  "genus": "Acinetobacter",
+  "species": "baumannii",
+  "full_name": "Acinetobacter baumannii",
+  "clinical_significance": "A major nosocomial pathogen associated with ventilator-associated pneumonia, bloodstream infections, meningitis, burn/wound infections, and device-related infections. Notorious for multidrug resistance including carbapenem resistance due to OXA-type carbapenemases.",
+  "phenotype_profile": {
+    "morphology": "Gram-negative coccobacilli; may appear as pairs or diplococci.",
+    "culture": "Dry, pale, dome-shaped colonies on blood agar; non-lactose fermenting on MacConkey agar. Growth at 44°C is a distinguishing trait.",
+    "biochemical": [
+      "Oxidase negative",
+      "Catalase positive",
+      "Non-fermenter",
+      "ONPG negative",
+      "No growth in 6.5% NaCl",
+      "Non-motile",
+      "Growth at 44°C (important discriminator)",
+      "May oxidize glucose weakly"
+    ]
+  },
+  "differentiation": {
+    "from_close_species": [
+      "A. baumannii grows at 44°C, unlike A. junii or A. lwoffii.",
+      "Shows greater antibiotic resistance compared to other Acinetobacter species.",
+      "Dry, adherent colonies are characteristic of baumannii complex.",
+      "Stronger environmental persistence compared to A. junii and A. lwoffii."
+    ],
+    "from_other_genera": [
+      "Oxidase negativity + non-motility differentiates it from most non-fermenters.",
+      "Neisseria/Moraxella are oxidase positive and coccoid; A. baumannii is oxidase negative.",
+      "Stenotrophomonas is motile; A. baumannii is non-motile."
+    ]
+  },
+  "virulence_factors": [
+    "Biofilm formation",
+    "Surface persistence and desiccation tolerance",
+    "OXA-type carbapenemases",
+    "Efflux pumps",
+    "Outer membrane protein A (OmpA)–mediated adherence"
+  ],
+  "confirmation_methods": [
+    "MALDI-TOF MS (most accurate)",
+    "Growth at 44°C",
+    "PCR assays for OXA-51-like genes (specific for baumannii complex)",
+    "16S rRNA sequencing"
+  ],
+  "treatment_notes": "Often extensively drug-resistant. Active agents may include colistin, minocycline, tigecycline, cefiderocol, or combination therapy. Susceptibility testing essential.",
+  "notes": "Acinetobacter baumannii complex contains multiple closely related species; phenotypic tests cannot reliably distinguish them.",
+  "references": [
+    "CDC & WHO MDR organism guidelines.",
+    "Manual of Clinical Microbiology."
+  ]
+}