Create actinomycetemcomitans.json

data/rag/knowledge_base/Actinobacillus/actinomycetemcomitans.json

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+{
+  "schema_version": "1.0",
+  "level": "species",
+  "genus": "Actinobacillus",
+  "species": "actinomycetemcomitans",
+
+  "overview": {
+    "short": "Actinobacillus actinomycetemcomitans is a Gram-negative coccobacillus associated with periodontal disease.",
+    "clinical_context": "Commonly isolated from oral infections, endocarditis, and periodontal lesions in humans."
+  },
+
+  "expected_fields": {
+    "Gram Stain": "Negative",
+    "Shape": "Short Rods",
+    "Motility": "Negative",
+    "Capsule": "Variable",
+    "Spore Formation": "Negative",
+    "Haemolysis": "Negative",
+    "Haemolysis Type": "None",
+    "Media Grown On": [
+      "Blood Agar",
+      "Chocolate Agar"
+    ],
+    "Colony Morphology": [
+      "Small",
+      "Grey",
+      "Smooth",
+      "Star-shaped internal structure"
+    ],
+    "Oxygen Requirement": "Facultative Anaerobe",
+    "Growth Temperature": "35//37",
+    "Catalase": "Positive",
+    "Oxidase": "Negative",
+    "Indole": "Negative",
+    "Urease": "Negative",
+    "Citrate": "Negative",
+    "Methyl Red": "Negative",
+    "VP": "Negative",
+    "H2S": "Negative",
+    "DNase": "Negative",
+    "ONPG": "Negative",
+    "Coagulase": "Negative",
+    "Gelatin Hydrolysis": "Negative",
+    "Esculin Hydrolysis": "Negative",
+    "Nitrate Reduction": "Variable",
+    "NaCl Tolerant (>=6%)": "Negative",
+    "Lipase Test": "Negative",
+    "Lysine Decarboxylase": "Negative",
+    "Ornithine Decarboxylase": "Negative",
+    "Ornitihine Decarboxylase": "Negative",
+    "Arginine dihydrolase": "Negative",
+    "Glucose Fermentation": "Positive",
+    "Lactose Fermentation": "Negative",
+    "Sucrose Fermentation": "Variable",
+    "Maltose Fermentation": "Variable",
+    "Mannitol Fermentation": "Variable",
+    "Sorbitol Fermentation": "Negative",
+    "Xylose Fermentation": "Variable",
+    "Rhamnose Fermentation": "Negative",
+    "Arabinose Fermentation": "Variable",
+    "Raffinose Fermentation": "Negative",
+    "Trehalose Fermentation": "Variable",
+    "Inositol Fermentation": "Negative",
+    "Gas Production": "Negative",
+    "TSI Pattern": "A/A",
+    "Colony Pattern": "Unknown",
+    "Pigment": "None",
+    "Motility Type": "None"
+  },
+
+  "species_markers": [
+    {
+      "field": "Colony Morphology",
+      "value": "Star-shaped internal structure",
+      "importance": "high",
+      "notes": "Characteristic colony appearance aids identification."
+    },
+    {
+      "field": "Clinical context",
+      "value": "Periodontal disease",
+      "importance": "high",
+      "notes": "Strong association with oral infections."
+    }
+  ],
+
+  "common_confusions": [
+    {
+      "genus": "Haemophilus",
+      "reason": "Similar growth requirements and oral habitat."
+    },
+    {
+      "genus": "Aggregatibacter",
+      "reason": "Taxonomic overlap and similar biochemical profiles."
+    }
+  ],
+
+  "when_to_question_identification": [
+    "Strong haemolysis suggests veterinary Actinobacillus species.",
+    "Lack of star-shaped colony morphology requires confirmation."
+  ],
+
+  "recommended_next_tests": [
+    {
+      "test": "MALDI-TOF MS",
+      "reason": "Reliable species-level identification."
+    },
+    {
+      "test": "16S rRNA sequencing",
+      "reason": "Used when phenotypic identification is inconclusive."
+    }
+  ]
+}