hackathon / _dashboard_state.json
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{
"timestamp": 1772999012.107634,
"step": 2,
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"model_response_raw": "{\n\"action_type\": \"select_cohort\",\n\"method\": None,\n\"parameters\": {\n\"categorical_variables\": [],\n\"factors_to_stratify_by\": []\n},\n\"Justification\": \"The recent historical sample was from 'blood', but the target tissue specified in the query ('synovial_fluid') differs significantly due to disease pathology affecting local fluid composition. Stratifying based on organ/tissue type ensures cohort homogeneity required for comparing RA vs non-RA controls within the specific joint space.\",\n\"Confidence\": 0.9\n}",
"model_thinking": "",
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"task": {
"problem_statement": "Determine the effect of JAK inhibitor treatment on T-cell activation states in rheumatoid arthritis.",
"organism": "human",
"tissue": "synovial_fluid",
"modality": "scRNA-seq",
"conditions": [
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"justification": "The recent historical sample was from 'blood', but the target tissue specified in the query ('synovial_fluid') differs significantly due to disease pathology affecting local fluid composition. Stratifying based on organ/tissue type ensures cohort homogeneity required for comparing RA vs non-RA controls within the specific joint space.",
"confidence": 0.9
},
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"summary": "Selected cohort of 4 samples with criteria {}",
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},
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{
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],
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},
{
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{
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{
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{
"name": "macrophage",
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],
"state": "inflammatory"
},
{
"name": "fibroblast",
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"marker_genes": [
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],
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},
{
"name": "B_cell",
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"marker_genes": [
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],
"state": "quiescent"
}
],
"true_markers": [
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"SOCS1",
"IFNG"
],
"causal_mechanisms": [
"JAK-STAT pathway inhibition reduces Th1/Th17 activation",
"Compensatory Treg expansion under JAK inhibition"
],
"true_pathways": {
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},
"hidden_failure_conditions": [
"High ambient RNA may confound DE in low-abundance transcripts"
]
}
}