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Open the cell-morphology board built from JUMP Cell Painting

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Structure-only prediction of how a compound changes cell shape, summarised to sixteen axes. Scored by per-compound profile correlation, with the metric uncertainty published as the threshold below which differences are not treated as rank.

board_meta.json CHANGED
@@ -1,29 +1,89 @@
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- {
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- "note": "λΆ€λ¬Έ μ΄λ¦„λ§ŒμœΌλ‘œλŠ” 무엇을 μž¬λŠ”μ§€ μ•Œ 수 μ—†λ‹€. ν‘œμ  κΈ°ν˜ΈλŠ” 이 λΆ„μ•Ό μ‚¬λžŒμ—κ²Œλ§Œ μ½νžŒλ‹€.",
3
- "boards": {
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- "hERG": {"ko": "심μž₯독성 β€” μΉΌλ₯¨μ±„널 차단", "en": "Cardiotoxicity β€” hERG channel block"},
5
- "Solubility": {"ko": "μˆ˜μš©ν•΄λ„ β€” 물에 λ…ΉλŠ” 정도", "en": "Aqueous solubility"},
6
- "Withdrawal": {"ko": "μ‹œνŒ ν›„ ν‡΄μΆœ νŒμ •", "en": "Post-marketing withdrawal"},
7
- "Phenotype": {"ko": "세포 ν˜•νƒœ λ³€ν™” 예츑", "en": "Cell morphology response"},
8
-
9
- "CYP3A4": {"ko": "λŒ€μ‚¬ μ €ν•΄ β€” μ•½λ¬Ό μƒν˜Έμž‘μš© μ΅œλŒ€ 원인", "en": "CYP3A4 inhibition β€” main cause of drug interaction"},
10
- "CYP2D6": {"ko": "λŒ€μ‚¬ μ €ν•΄ β€” κ°œμΈμ°¨κ°€ 큰 νš¨μ†Œ", "en": "CYP2D6 inhibition β€” highly polymorphic enzyme"},
11
- "CYP2C9": {"ko": "λŒ€μ‚¬ μ €ν•΄ β€” μ™€νŒŒλ¦° 계열", "en": "CYP2C9 inhibition β€” warfarin class"},
12
-
13
- "EGFR": {"ko": "폐암 ν‘œμ  β€” 상피성μž₯인자 수용체", "en": "Lung cancer target β€” EGF receptor"},
14
- "JAK2": {"ko": "κ³¨μˆ˜μ¦μ‹μ§ˆν™˜ ν‘œμ ", "en": "Myeloproliferative disease target"},
15
- "PI3Ka": {"ko": "μ’…μ–‘ μ‹ ν˜Έμ „λ‹¬ ν‘œμ ", "en": "Tumour signalling target"},
16
- "FLT3": {"ko": "κΈ‰μ„±κ³¨μˆ˜λ°±ν˜ˆλ³‘ ν‘œμ ", "en": "Acute myeloid leukaemia target"},
17
- "VEGFR2": {"ko": "ν˜ˆκ΄€μ‹ μƒ ν‘œμ  β€” μ’…μ–‘ ν˜ˆκ΄€ 차단", "en": "Angiogenesis target"},
18
- "CDK2": {"ko": "세포주기 ν‘œμ ", "en": "Cell cycle target"},
19
- "HER2": {"ko": "μœ λ°©μ•” ν‘œμ ", "en": "Breast cancer target"},
20
- "ABL1": {"ko": "λ§Œμ„±κ³¨μˆ˜λ°±ν˜ˆλ³‘ ν‘œμ ", "en": "Chronic myeloid leukaemia target"},
21
- "BRAF": {"ko": "흑색쒅 ν‘œμ ", "en": "Melanoma target"},
22
- "KIT": {"ko": "μœ„μž₯κ΄€κΈ°μ§ˆμ’…μ–‘ ν‘œμ ", "en": "GIST target"},
23
- "ALK": {"ko": "폐암 μœ΅ν•© ν‘œμ ", "en": "Lung cancer fusion target"},
24
-
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- "AChE": {"ko": "μ•ŒμΈ ν•˜μ΄λ¨Έ ν‘œμ  β€” μ•„μ„Έν‹Έμ½œλ¦° λΆ„ν•΄νš¨μ†Œ", "en": "Alzheimer target β€” acetylcholinesterase"},
26
- "MAOB": {"ko": "νŒŒν‚¨μŠ¨ ν‘œμ  β€” λͺ¨λ…Έμ•„λ―Ό μ‚°ν™”νš¨μ†Œ B", "en": "Parkinson target β€” monoamine oxidase B"},
27
- "COX2": {"ko": "μ†Œμ—Όμ§„ν†΅ ν‘œμ ", "en": "Anti-inflammatory target"}
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- }
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- }
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ {
2
+ "note": "λΆ€λ¬Έ μ΄λ¦„λ§ŒμœΌλ‘œλŠ” 무엇을 μž¬λŠ”μ§€ μ•Œ 수 μ—†λ‹€. ν‘œμ  κΈ°ν˜ΈλŠ” 이 λΆ„μ•Ό μ‚¬λžŒμ—κ²Œλ§Œ μ½νžŒλ‹€.",
3
+ "boards": {
4
+ "hERG": {
5
+ "ko": "심μž₯독성 β€” μΉΌλ₯¨μ±„널 차단",
6
+ "en": "Cardiotoxicity β€” hERG channel block"
7
+ },
8
+ "Solubility": {
9
+ "ko": "μˆ˜μš©ν•΄λ„ β€” 물에 λ…ΉλŠ” 정도",
10
+ "en": "Aqueous solubility"
11
+ },
12
+ "Withdrawal": {
13
+ "ko": "μ‹œνŒ ν›„ ν‡΄μΆœ νŒμ •",
14
+ "en": "Post-marketing withdrawal"
15
+ },
16
+ "Phenotype": {
17
+ "ko": "세포 ν˜•νƒœ λ³€ν™” β€” ꡬ쑰만 보고 예츑",
18
+ "en": "Cell morphology response from structure alone"
19
+ },
20
+ "CYP3A4": {
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+ "ko": "λŒ€μ‚¬ μ €ν•΄ β€” μ•½λ¬Ό μƒν˜Έμž‘μš© μ΅œλŒ€ 원인",
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+ "en": "CYP3A4 inhibition β€” main cause of drug interaction"
23
+ },
24
+ "CYP2D6": {
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+ "ko": "λŒ€μ‚¬ μ €ν•΄ β€” κ°œμΈμ°¨κ°€ 큰 νš¨μ†Œ",
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+ "en": "CYP2D6 inhibition β€” highly polymorphic enzyme"
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+ },
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+ "CYP2C9": {
29
+ "ko": "λŒ€μ‚¬ μ €ν•΄ β€” μ™€νŒŒλ¦° 계열",
30
+ "en": "CYP2C9 inhibition β€” warfarin class"
31
+ },
32
+ "EGFR": {
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+ "ko": "폐암 ν‘œμ  β€” 상피성μž₯인자 수용체",
34
+ "en": "Lung cancer target β€” EGF receptor"
35
+ },
36
+ "JAK2": {
37
+ "ko": "κ³¨μˆ˜μ¦μ‹μ§ˆν™˜ ν‘œμ ",
38
+ "en": "Myeloproliferative disease target"
39
+ },
40
+ "PI3Ka": {
41
+ "ko": "μ’…μ–‘ μ‹ ν˜Έμ „λ‹¬ ν‘œμ ",
42
+ "en": "Tumour signalling target"
43
+ },
44
+ "FLT3": {
45
+ "ko": "κΈ‰μ„±κ³¨μˆ˜λ°±ν˜ˆλ³‘ ν‘œμ ",
46
+ "en": "Acute myeloid leukaemia target"
47
+ },
48
+ "VEGFR2": {
49
+ "ko": "ν˜ˆκ΄€μ‹ μƒ ν‘œμ  β€” μ’…μ–‘ ν˜ˆκ΄€ 차단",
50
+ "en": "Angiogenesis target"
51
+ },
52
+ "CDK2": {
53
+ "ko": "세포주기 ν‘œμ ",
54
+ "en": "Cell cycle target"
55
+ },
56
+ "HER2": {
57
+ "ko": "μœ λ°©μ•” ν‘œμ ",
58
+ "en": "Breast cancer target"
59
+ },
60
+ "ABL1": {
61
+ "ko": "λ§Œμ„±κ³¨μˆ˜λ°±ν˜ˆλ³‘ ν‘œμ ",
62
+ "en": "Chronic myeloid leukaemia target"
63
+ },
64
+ "BRAF": {
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+ "ko": "흑색쒅 ν‘œμ ",
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+ "en": "Melanoma target"
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+ },
68
+ "KIT": {
69
+ "ko": "μœ„μž₯κ΄€κΈ°μ§ˆμ’…μ–‘ ν‘œμ ",
70
+ "en": "GIST target"
71
+ },
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+ "ALK": {
73
+ "ko": "폐암 μœ΅ν•© ν‘œμ ",
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+ "en": "Lung cancer fusion target"
75
+ },
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+ "AChE": {
77
+ "ko": "μ•ŒμΈ ν•˜μ΄λ¨Έ ν‘œμ  β€” μ•„μ„Έν‹Έμ½œλ¦° λΆ„ν•΄νš¨μ†Œ",
78
+ "en": "Alzheimer target β€” acetylcholinesterase"
79
+ },
80
+ "MAOB": {
81
+ "ko": "νŒŒν‚¨μŠ¨ ν‘œμ  β€” λͺ¨λ…Έμ•„λ―Ό μ‚°ν™”νš¨μ†Œ B",
82
+ "en": "Parkinson target β€” monoamine oxidase B"
83
+ },
84
+ "COX2": {
85
+ "ko": "μ†Œμ—Όμ§„ν†΅ ν‘œμ ",
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+ "en": "Anti-inflammatory target"
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+ }
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+ }
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+ }
categories.json CHANGED
@@ -112,7 +112,9 @@
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  "icon": "πŸ”¬",
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  "desc": "약이 μ‹€μ œ 세포에 무슨 짓을 ν•˜λŠ”κ°€",
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  "planned": 5,
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- "boards": [],
 
 
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  "desc_en": "What a compound actually does to a living cell"
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  },
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  {
 
112
  "icon": "πŸ”¬",
113
  "desc": "약이 μ‹€μ œ 세포에 무슨 짓을 ν•˜λŠ”κ°€",
114
  "planned": 5,
115
+ "boards": [
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+ "Phenotype"
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+ ],
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  "desc_en": "What a compound actually does to a living cell"
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  },
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  {
data/phenotype_card.json ADDED
@@ -0,0 +1,49 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ {
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+ "board": "Phenotype",
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+ "target": "β€”",
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+ "type": "ν˜•νƒœ ν”„λ‘œνŒŒμΌ 16μΆ• (Cell Painting)",
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+ "cut": null,
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+ "threshold": null,
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+ "n_train": 113688,
8
+ "n_test": 2001,
9
+ "positive_rate": 0.0,
10
+ "noise_floor": {
11
+ "sd_single": 0.0088231485954581,
12
+ "pairs": 600,
13
+ "compounds": 2001,
14
+ "median": 0.0088231485954581,
15
+ "mean": 0.0088231485954581,
16
+ "p90": 0.014469963696551284,
17
+ "kind": "metric_bootstrap"
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+ },
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+ "baselines": {
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+ "μƒμˆ˜ 예츑": {
21
+ "mae": 3.402697801589966,
22
+ "auroc": null,
23
+ "prauc": null,
24
+ "profile_corr": 0.09155943244695663
25
+ },
26
+ "μ΅œκ·Όμ ‘ 이웃": {
27
+ "mae": 4.604068756103516,
28
+ "auroc": null,
29
+ "prauc": null,
30
+ "profile_corr": 0.07925715297460556
31
+ },
32
+ "Morgan+LightGBM": {
33
+ "mae": 3.3996472241179068,
34
+ "auroc": null,
35
+ "prauc": null,
36
+ "profile_corr": 0.15912491324360925
37
+ }
38
+ },
39
+ "near_threshold": 0,
40
+ "explained_variance": 0.6100924015045166,
41
+ "split_grade": "S",
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+ "split_grade_note": "골격 λΆ„ν•  Β· ν›ˆλ ¨μ— μ—†λŠ” 골격만 평가",
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+ "answer_grade": "P1",
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+ "answer_grade_note": "JUMP λŠ” μ™„μ „ 곡개 μžλ£Œλ‹€. 쑰회 λ°©μ–΄λŠ” 8μ‘°κ°€ λ‹΄λ‹Ήν•œλ‹€",
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+ "source": "JUMP Cell Painting Β· CC0",
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+ "built": "2026-08-22",
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+ "metric": "profile_corr",
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+ "primary": "ν”„λ‘œνŒŒμΌ 상관 (λ†’μ„μˆ˜λ‘ μ’‹μŒ)"
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+ }
data/phenotype_test.json ADDED
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