Spaces:
Running
Running
Update README.md
Browse files
README.md
CHANGED
|
@@ -19,10 +19,10 @@ As genomic datasets grow exponentially, the need for rapid, automated sequence a
|
|
| 19 |
## The 4-Stage Cascading Architecture
|
| 20 |
Our platform utilizes a highly specialized, branching AI architecture hosted on Hugging Face ZeroGPU infrastructure:
|
| 21 |
|
| 22 |
-
1. **Level 1: The Gene Finder (Coding vs. Non-Coding):** A
|
| 23 |
2. **Level 2: The Multi-Feature Classifier (LightGBM):** Sequences flagged as coding are passed through a LightGBM gradient boosting model to classify them into one of 7 highly specific structural features.
|
| 24 |
3. **Level 3: Phenotype Classification (Lean vs. Obese):** A custom ALiBi-configured BERT architecture evaluates specific coding regions to predict downstream phenotypic associations.
|
| 25 |
-
4. **Level 4: The Promoter Network (DNABERT-2):** Sequences flagged as non-coding are routed to a
|
| 26 |
|
| 27 |
**Integration:** The pipeline concludes with an automated API routing to NCBI and Ensembl databases for real-world chromosomal coordinate mapping and validation.
|
| 28 |
|
|
|
|
| 19 |
## The 4-Stage Cascading Architecture
|
| 20 |
Our platform utilizes a highly specialized, branching AI architecture hosted on Hugging Face ZeroGPU infrastructure:
|
| 21 |
|
| 22 |
+
1. **Level 1: The Gene Finder (Coding vs. Non-Coding):** A logistic regression machine learning classifier that rapidly screens raw k-mer vectors to identify protein-coding potential.
|
| 23 |
2. **Level 2: The Multi-Feature Classifier (LightGBM):** Sequences flagged as coding are passed through a LightGBM gradient boosting model to classify them into one of 7 highly specific structural features.
|
| 24 |
3. **Level 3: Phenotype Classification (Lean vs. Obese):** A custom ALiBi-configured BERT architecture evaluates specific coding regions to predict downstream phenotypic associations.
|
| 25 |
+
4. **Level 4: The Promoter Network (DNABERT-2):** Sequences flagged as non-coding are routed to a neural network transformer model that analyzes spatial attention tensors to identify regulatory promoter regions.
|
| 26 |
|
| 27 |
**Integration:** The pipeline concludes with an automated API routing to NCBI and Ensembl databases for real-world chromosomal coordinate mapping and validation.
|
| 28 |
|