---
title: Biological Uncertainty Stack
emoji: 🧬
colorFrom: blue
colorTo: indigo
sdk: static
app_file: index.html
pinned: false
license: cc-by-nc-4.0
short_description: Genomic uncertainty provenance map
tags:
  - genomics
  - GRCh38
  - biological-uncertainty
  - provenance
  - uncertainty-governance
  - systems-integrity
  - HIR
  - OAM
---

# Biological Uncertainty Stack

Biological Uncertainty Stack is a public HIR/OAM architecture map for genomic uncertainty, GRCh38 reference limits, provenance gates, measurement failure, and hard blocks against hidden positive evidence.

This Space uses the **Primordial DNA Layer · GRCh38 First-Pass Architecture Plan v0.1** as its source direction. It treats GRCh38 / GRCh38.p14 as Source Layer 1: an initial baseline reference frame for first-pass feature typing and uncertainty mapping, not a complete model of human diversity and not a final biological authority.

## Search target / source file

```text
Primordial_DNA_GRCh38_First_Pass_Architecture_Plan_v0.1.html
```

## Non-negotiable invariant

Unknown biology may preserve possibility space. Untrusted data may invalidate the comparison. Neither may be converted into hidden positive evidence.

Biological unresolvedness does not equal measurement/provenance unresolvedness. These categories must remain separate throughout all schemas, scoring, and downstream layers.

## Boundary

This is a bounded architecture and public review prototype.

It is not clinical advice, diagnosis, treatment guidance, identity proof, family-relation proof, forensic conclusion, ancestry result, genetic counseling, or validated genomic-comparison software.

GRCh38 is used as a reference frame only. All genomic inferences beyond declared evidence limits are explicitly blocked by the HIR rule set.

Structural correspondence, not ontological equivalence.

## Ecosystem position

This Space is part of the broader Primordial Code Ecosystem.

Parent hub:
https://huggingface.co/spaces/HirModel/primordial-code-ecosystem

Collection:
https://huggingface.co/collections/HirModel/primordial-code-ecosystem

This module is the biological-uncertainty and genomic provenance branch of the HIR/OAM life-first systems-integrity architecture.

## Ecosystem position

This Space is part of the broader Primordial Code Ecosystem.

Parent hub:
https://huggingface.co/spaces/HirModel/primordial-code-ecosystem

This module is one bounded branch of the HIR/OAM life-first systems-integrity architecture.