| <!DOCTYPE html> |
| <html lang="en"> |
| <head> |
| <meta charset="utf-8"> |
| <meta name="viewport" content="width=device-width, initial-scale=1.0"> |
| <title>Perturbation Impact on HBB Gene Scores</title> |
| <meta name="color-scheme" content="light"> |
| <link rel="preconnect" href="https://fonts.googleapis.com"> |
| <link rel="preconnect" href="https://fonts.gstatic.com" crossorigin> |
| <link rel="stylesheet" href="https://fonts.googleapis.com/css2?family=JetBrains+Mono:wght@300;400;500;600;700&family=Inter:wght@300;400;500;600&display=swap"> |
| <style> |
| |
| :root { |
| --bg: #f7f5ee; |
| --ink: #1f1f1d; |
| --ink-soft: #5b5b56; |
| --ink-faint: #8a8a83; |
| --rule: #e3e1d6; |
| --hair: #eee; |
| --green: #317f3f; |
| --green-dark: #1f5024; |
| --green-tint: #f4f8f4; |
| --amber: #b8862c; |
| --amber-dark: #6b4d18; |
| --red: #b00020; |
| --blue: #2c5aa0; |
| --card: #fff; |
| --soft-cream: #fafaf6; |
| --base-a: #1A7A40; |
| --base-t: #b00020; |
| --base-c: #2c5aa0; |
| --base-g: #b8862c; |
| } |
| * { margin: 0; padding: 0; box-sizing: border-box; } |
| html { scroll-behavior: smooth; } |
| body { |
| font-family: "Inter", "Helvetica Neue", sans-serif; |
| font-size: 14px; font-weight: 300; line-height: 1.7; |
| color: var(--ink); |
| background: var(--bg); |
| } |
| ::-webkit-scrollbar { width: 8px; height: 8px; } |
| ::-webkit-scrollbar-thumb { background: #ccc; border-radius: 4px; } |
| ::-webkit-scrollbar-track { background: transparent; } |
| |
| |
| .page-header { |
| border-bottom: 1px solid var(--rule); |
| background: var(--bg); |
| position: sticky; top: 0; z-index: 50; |
| backdrop-filter: saturate(180%) blur(6px); |
| } |
| .page-header__inner { |
| max-width: 1200px; |
| margin: 0 auto; |
| padding: 14px 32px; |
| display: flex; align-items: baseline; gap: 16px; |
| } |
| .wordmark { |
| font-family: "JetBrains Mono", monospace; |
| font-weight: 700; |
| font-size: 16px; |
| letter-spacing: 1px; |
| } |
| .wordmark .caret { color: var(--green); margin-right: 4px; } |
| .wordmark__sub { |
| font-family: "JetBrains Mono", monospace; |
| font-size: 11px; font-weight: 500; |
| text-transform: uppercase; letter-spacing: 2px; |
| color: var(--ink-soft); |
| margin-left: 4px; |
| } |
| .page-header__spacer { flex: 1; } |
| .page-header__crumbs { |
| font-family: "JetBrains Mono", monospace; |
| font-size: 10px; letter-spacing: 1.4px; |
| text-transform: uppercase; color: var(--ink-faint); |
| } |
| .page-header__crumbs a { color: var(--ink-soft); text-decoration: none; } |
| .page-header__crumbs a:hover { color: var(--green); } |
| |
| |
| .tab-lede { |
| max-width: 1200px; margin: 56px auto 0; |
| padding: 0 32px; |
| } |
| .tab-lede__rail { |
| border-left: 3px solid var(--green); |
| padding: 4px 0 4px 22px; |
| max-width: 820px; |
| } |
| .tab-lede__eyebrow { |
| display: block; |
| font-family: "JetBrains Mono", monospace; |
| font-size: 11px; font-weight: 500; |
| letter-spacing: 0.22em; text-transform: uppercase; |
| color: var(--green); margin-bottom: 12px; |
| } |
| .tab-lede__title { |
| margin: 0 0 22px; |
| font-family: "JetBrains Mono", monospace; |
| font-size: 34px; font-weight: 500; |
| letter-spacing: -0.01em; line-height: 1.12; |
| color: var(--ink); |
| } |
| .tab-lede__lead { |
| margin: 0; max-width: 760px; |
| font-family: "Inter", sans-serif; |
| font-size: 19px; font-weight: 300; line-height: 1.5; |
| letter-spacing: -0.005em; color: #2d2d2a; |
| } |
| |
| |
| .post { |
| max-width: 760px; |
| margin: 32px auto 0; |
| padding: 0 32px 96px; |
| } |
| .post h2 { |
| margin: 64px 0 18px; |
| font-family: "JetBrains Mono", monospace; |
| font-size: 22px; font-weight: 500; |
| letter-spacing: -0.005em; line-height: 1.3; |
| color: var(--ink); |
| padding-top: 12px; |
| border-top: 1px solid var(--rule); |
| } |
| .post h2:first-child { border-top: none; padding-top: 0; } |
| .post h3 { |
| margin: 40px 0 12px; |
| font-family: "JetBrains Mono", monospace; |
| font-size: 15px; font-weight: 500; |
| letter-spacing: 0; |
| color: var(--ink); |
| text-transform: uppercase; |
| letter-spacing: 0.5px; |
| } |
| .post p { margin: 0 0 14px; } |
| .post p > code, .post li > code { |
| font-family: "JetBrains Mono", monospace; |
| font-size: 0.86em; |
| background: var(--soft-cream); |
| border: 1px solid var(--rule); |
| padding: 1px 5px; |
| border-radius: 2px; |
| color: var(--green-dark); |
| } |
| .post pre { |
| margin: 14px 0 18px; |
| padding: 14px 16px; |
| background: var(--card); |
| border: 1px solid #ddd; |
| overflow-x: auto; |
| } |
| .post pre code { |
| font-family: "JetBrains Mono", monospace; |
| font-size: 12px; line-height: 1.6; |
| color: var(--ink); |
| background: transparent; border: none; padding: 0; |
| } |
| .post a { |
| color: var(--green-dark); |
| text-decoration: underline; |
| text-decoration-thickness: 1px; |
| text-underline-offset: 2px; |
| } |
| .post a:hover { color: var(--green); } |
| .post strong { font-weight: 600; color: var(--ink); } |
| .post-image { |
| margin: 24px 0; |
| } |
| .post-image img { |
| display: block; |
| width: 100%; height: auto; |
| border: 1px solid var(--rule); |
| } |
| |
| |
| .widget { |
| max-width: 920px; |
| margin: 40px auto 8px; |
| } |
| .widget__head { |
| display: flex; align-items: baseline; gap: 14px; |
| margin-bottom: 6px; |
| } |
| .widget__eyebrow { |
| font-family: "JetBrains Mono", monospace; |
| font-size: 10px; font-weight: 500; |
| letter-spacing: 0.22em; text-transform: uppercase; |
| color: var(--green); |
| } |
| .widget__title { |
| font-family: "JetBrains Mono", monospace; |
| font-size: 14px; font-weight: 500; |
| color: var(--ink); letter-spacing: 0; |
| } |
| .widget__caption { |
| font-family: "Inter", sans-serif; |
| font-size: 12px; color: var(--ink-soft); |
| margin: 8px 4px 14px; |
| line-height: 1.5; |
| } |
| .demo { |
| background: var(--card); border: 1px solid #ddd; |
| padding: 22px; margin: 8px 0; |
| } |
| .demo-toolbar { |
| display: flex; gap: 8px; align-items: center; flex-wrap: wrap; |
| margin-bottom: 14px; |
| font-family: "JetBrains Mono", monospace; font-size: 10px; |
| color: #666; text-transform: uppercase; letter-spacing: 1.4px; |
| } |
| .demo-toolbar .spacer { flex: 1; } |
| .demo-label { |
| font-family: "JetBrains Mono", monospace; |
| font-size: 9.5px; color: #6b7a6e; |
| text-transform: uppercase; letter-spacing: 1.6px; |
| margin: 6px 0 6px; |
| } |
| |
| .pill, button.action { |
| font-family: "JetBrains Mono", monospace; |
| font-size: 11px; font-weight: 400; |
| padding: 5px 11px; border: 1px solid #ccc; border-radius: 3px; |
| background: #fff; color: #555; cursor: pointer; |
| text-transform: uppercase; letter-spacing: 1.5px; |
| transition: all 0.12s; |
| } |
| .pill:hover, button.action:hover { border-color: #888; color: var(--ink); } |
| .pill.active, button.action.primary { background: var(--ink); color: #fff; border-color: var(--ink); } |
| .pill.active:hover, button.action.primary:hover { background: #000; } |
| .pill.gh { background: var(--green); color: #fff; border-color: var(--green); } |
| .pill.gh:hover { background: var(--green-dark); border-color: var(--green-dark); } |
| .pills { display: inline-flex; flex-wrap: wrap; gap: 6px; } |
| .status { |
| font-family: "JetBrains Mono", monospace; |
| font-size: 10px; color: #666; |
| text-transform: uppercase; letter-spacing: 1.5px; |
| display: inline-flex; align-items: center; gap: 6px; |
| margin-left: 8px; |
| } |
| .status .dot { |
| display: inline-block; width: 6px; height: 6px; border-radius: 50%; |
| background: var(--green); |
| } |
| |
| input.seq-input, textarea.seq-input { |
| width: 100%; |
| font-family: "JetBrains Mono", monospace; |
| font-size: 13px; |
| padding: 9px 12px; |
| border: 1px solid #ccc; |
| border-radius: 3px; |
| letter-spacing: 1px; |
| text-transform: uppercase; |
| color: var(--ink); |
| background: var(--soft-cream); |
| resize: vertical; |
| } |
| textarea.seq-input { letter-spacing: 0.5px; } |
| input.seq-input:focus, textarea.seq-input:focus { |
| outline: none; |
| border-color: var(--green); |
| background: #fff; |
| } |
| |
| |
| .base, .tok { |
| font-family: "JetBrains Mono", monospace; |
| font-size: 11px; |
| letter-spacing: 0.5px; |
| } |
| .base { |
| display: inline-block; |
| padding: 2px 5px; |
| font-weight: 500; |
| margin: 1px; |
| color: #fff; |
| border-radius: 2px; |
| min-width: 16px; |
| text-align: center; |
| } |
| .base.A { background: var(--base-a); } |
| .base.T { background: var(--base-t); } |
| .base.C { background: var(--base-c); } |
| .base.G { background: var(--base-g); } |
| .base.dim { opacity: 0.4; } |
| .base.outline { |
| background: transparent; |
| border: 1px solid currentColor; |
| } |
| .base.outline.A { color: var(--base-a); } |
| .base.outline.T { color: var(--base-t); } |
| .base.outline.C { color: var(--base-c); } |
| .base.outline.G { color: var(--base-g); } |
| |
| .tok { |
| display: inline-flex; |
| align-items: center; |
| padding: 4px 8px; |
| margin: 2px; |
| border: 1px solid #ccc; |
| border-radius: 3px; |
| background: #fff; |
| color: var(--ink); |
| } |
| .tok.kmer { |
| background: rgba(49,127,63,0.10); |
| border-color: rgba(49,127,63,0.5); |
| color: var(--green-dark); |
| font-weight: 500; |
| } |
| .tok.bpe { |
| background: rgba(184,134,44,0.10); |
| border-color: rgba(184,134,44,0.5); |
| color: var(--amber-dark); |
| } |
| .tok.text { |
| background: #fff; |
| border-color: #ccc; |
| color: var(--ink); |
| } |
| .tok.boundary { |
| background: var(--ink); |
| color: #fff; |
| border-color: var(--ink); |
| text-transform: uppercase; |
| letter-spacing: 1px; |
| font-size: 10px; |
| } |
| .tok.dim { color: #888; background: var(--soft-cream); } |
| .tok.ok { background: var(--green); color: #fff; border-color: var(--green); } |
| .tok.bad { color: var(--red); border-color: rgba(176,0,32,0.4); background: rgba(176,0,32,0.05); } |
| .tok.selected { |
| outline: 2px solid var(--green); |
| outline-offset: 1px; |
| } |
| .token-row { display: flex; flex-wrap: wrap; align-items: center; gap: 0; } |
| |
| |
| .count-badge { |
| display: inline-block; |
| font-family: "JetBrains Mono", monospace; |
| font-size: 10px; font-weight: 600; |
| background: var(--ink); color: var(--bg); |
| padding: 2px 7px; border-radius: 2px; |
| letter-spacing: 1px; |
| } |
| .count-badge.green { background: var(--green); color: #fff; } |
| .count-badge.amber { background: var(--amber); color: #fff; } |
| |
| |
| .tk-anim { margin-top: 18px; } |
| .tk-source, .tk-scheme { |
| display: grid; |
| grid-template-columns: 124px 1fr; |
| gap: 18px; |
| align-items: start; |
| padding: 8px 0; |
| } |
| .tk-scheme { padding: 10px 0; min-height: 32px; } |
| .tk-source { padding-bottom: 14px; border-bottom: 1px solid var(--rule); margin-bottom: 6px; } |
| .tk-meta { |
| display: flex; |
| flex-direction: column; |
| gap: 3px; |
| padding-top: 2px; |
| } |
| .tk-label { |
| font-family: "JetBrains Mono", monospace; |
| font-size: 9.5px; |
| font-weight: 500; |
| color: var(--ink-soft); |
| text-transform: uppercase; |
| letter-spacing: 1.6px; |
| } |
| .tk-stat { |
| font-family: "JetBrains Mono", monospace; |
| font-size: 10px; |
| color: var(--ink-faint); |
| letter-spacing: 0.5px; |
| font-variant-numeric: tabular-nums; |
| } |
| .tk-stat .n { |
| font-weight: 600; |
| color: var(--ink); |
| } |
| .tk-scheme[data-scheme="bpe"] .tk-stat .n { color: var(--amber-dark); } |
| .tk-scheme[data-scheme="kmer"] .tk-stat .n { color: var(--green-dark); } |
| |
| |
| .tk-source-strip { |
| display: flex; |
| flex-wrap: wrap; |
| row-gap: 2px; |
| } |
| .tk-source-strip .tk-base { |
| display: inline-flex; |
| align-items: center; |
| justify-content: center; |
| width: 13px; |
| height: 17px; |
| color: #fff; |
| font-family: "JetBrains Mono", monospace; |
| font-size: 10px; |
| font-weight: 500; |
| border-radius: 1px; |
| flex: 0 0 13px; |
| transition: opacity 0.35s ease, filter 0.35s ease; |
| } |
| .tk-source-strip .tk-base + .tk-base { margin-left: 1px; } |
| .tk-source-strip .tk-base.consumed { opacity: 0.18; filter: grayscale(0.6); } |
| .tk-base.A { background: var(--base-a); } |
| .tk-base.T { background: var(--base-t); } |
| .tk-base.C { background: var(--base-c); } |
| .tk-base.G { background: var(--base-g); } |
| |
| |
| .tk-scheme-strip { |
| display: flex; |
| flex-wrap: wrap; |
| gap: 1px 8px; |
| min-height: 20px; |
| } |
| .tk-token { |
| font-family: "JetBrains Mono", monospace; |
| font-size: 12px; |
| font-weight: 500; |
| letter-spacing: 0.5px; |
| display: inline-flex; |
| align-items: center; |
| opacity: 0; |
| will-change: transform, opacity; |
| } |
| .tk-token.dropped { |
| opacity: 1; |
| transition: |
| transform 0.48s cubic-bezier(0.22, 1, 0.36, 1), |
| opacity 0.32s ease; |
| } |
| .tk-token .br { color: var(--ink-faint); font-weight: 400; } |
| .tk-token.tail .br { color: var(--ink-faint); } |
| .tk-token.tail { opacity: 0.55; } |
| .tk-token.tail.dropped { opacity: 0.55; } |
| |
| |
| |
| .grid-3 { |
| display: grid; |
| grid-template-columns: 1fr 1fr 1fr; |
| gap: 14px; |
| margin-top: 14px; |
| } |
| .grid-2 { |
| display: grid; |
| grid-template-columns: 1fr 1fr; |
| gap: 14px; |
| margin-top: 14px; |
| } |
| @media (max-width: 720px) { |
| .grid-3, .grid-2 { grid-template-columns: 1fr; } |
| } |
| .col-card { |
| background: var(--soft-cream); |
| border: 1px solid var(--rule); |
| padding: 14px; |
| } |
| .col-card .col-title { |
| font-family: "JetBrains Mono", monospace; |
| font-size: 10px; font-weight: 500; |
| letter-spacing: 1.6px; text-transform: uppercase; |
| color: var(--ink-soft); |
| margin-bottom: 8px; |
| } |
| .col-card .col-foot { |
| margin-top: 10px; |
| display: flex; align-items: center; gap: 8px; |
| font-family: "JetBrains Mono", monospace; |
| font-size: 10px; color: var(--ink-soft); |
| text-transform: uppercase; letter-spacing: 1.4px; |
| } |
| |
| |
| .bar-row { |
| display: grid; |
| grid-template-columns: 18px 1fr 64px; |
| align-items: center; |
| gap: 8px; |
| margin: 3px 0; |
| font-family: "JetBrains Mono", monospace; |
| font-size: 11px; |
| } |
| .bar-row .bar-label { color: var(--ink-soft); font-weight: 500; text-align: center; } |
| .bar-row .bar-track { |
| position: relative; |
| height: 14px; |
| background: var(--soft-cream); |
| border: 1px solid var(--rule); |
| } |
| .bar-row .bar-fill { |
| height: 100%; |
| transition: width 220ms ease, background-color 220ms ease; |
| } |
| .bar-row .bar-val { text-align: right; color: var(--ink); font-variant-numeric: tabular-nums; } |
| .bar-row.highlight .bar-track { box-shadow: 0 0 0 2px var(--green-tint); } |
| |
| |
| .posgrid { |
| display: grid; |
| grid-template-columns: repeat(6, 1fr); |
| gap: 8px; |
| } |
| .posgrid__col { |
| background: var(--soft-cream); |
| border: 1px solid var(--rule); |
| border-radius: 2px; |
| padding: 8px 6px 6px; |
| } |
| .posgrid__pos { |
| font-family: "JetBrains Mono", monospace; |
| font-size: 9px; color: var(--ink-faint); |
| text-transform: uppercase; letter-spacing: 1.4px; |
| text-align: center; margin-bottom: 6px; |
| } |
| .posgrid__bars { |
| display: flex; flex-direction: column; gap: 3px; |
| } |
| .posgrid .mini-row { |
| display: grid; grid-template-columns: 12px 1fr 32px; |
| align-items: center; gap: 4px; |
| font-family: "JetBrains Mono", monospace; font-size: 10px; |
| } |
| .posgrid .mini-row .ml { color: var(--ink-soft); text-align: center; font-weight: 500; } |
| .posgrid .mini-row .mt { position: relative; height: 10px; background: #fff; border: 1px solid var(--rule); } |
| .posgrid .mini-row .mf { display: block; height: 100%; transition: width 200ms ease; } |
| .posgrid .mini-row .mv { text-align: right; color: var(--ink); font-variant-numeric: tabular-nums; font-size: 9.5px; } |
| .posgrid__col.argmax-A { box-shadow: inset 0 0 0 1px var(--base-a); } |
| .posgrid__col.argmax-T { box-shadow: inset 0 0 0 1px var(--base-t); } |
| .posgrid__col.argmax-C { box-shadow: inset 0 0 0 1px var(--base-c); } |
| .posgrid__col.argmax-G { box-shadow: inset 0 0 0 1px var(--base-g); } |
| .posgrid__col.locked { background: #fff; } |
| .posgrid__col.frozen .posgrid__bars { opacity: 0.4; } |
| .posgrid__sel { display: flex; gap: 3px; margin-top: 8px; } |
| .cond-pick { |
| flex: 1 1 0; min-width: 0; |
| font-family: "JetBrains Mono", monospace; font-size: 10px; font-weight: 600; |
| padding: 3px 0; border: 1px solid var(--rule); border-radius: 2px; |
| background: #fff; cursor: pointer; |
| transition: background 0.12s, border-color 0.12s, color 0.12s; |
| } |
| .cond-pick:hover { border-color: #888; } |
| .cond-pick.active { color: #fff; } |
| .cond-pick.active.b-A { background: var(--base-a); border-color: var(--base-a); } |
| .cond-pick.active.b-T { background: var(--base-t); border-color: var(--base-t); } |
| .cond-pick.active.b-C { background: var(--base-c); border-color: var(--base-c); } |
| .cond-pick.active.b-G { background: var(--base-g); border-color: var(--base-g); } |
| |
| |
| .w3-itok { cursor: pointer; transition: outline-color 0.12s; } |
| .w3-itok:hover { border-color: #888; } |
| .w3-sub { |
| font-family: "JetBrains Mono", monospace; |
| font-size: 11px; color: var(--ink-soft); |
| margin: 2px 0 10px; line-height: 1.7; |
| } |
| .w3-sub b { color: var(--ink); font-weight: 600; } |
| .w3-sub .tok { margin: 0 2px; } |
| .w3-toprow { |
| display: grid; |
| grid-template-columns: 92px 1fr 52px; |
| gap: 12px; align-items: center; |
| margin: 4px 0; |
| font-family: "JetBrains Mono", monospace; font-size: 11px; |
| } |
| .w3-toprow .km { font-weight: 500; letter-spacing: 0.5px; } |
| .w3-toprow .bar { height: 13px; background: var(--soft-cream); border: 1px solid var(--rule); } |
| .w3-toprow .fill { height: 100%; background: var(--green); transition: width 0.35s ease; } |
| .w3-toprow .pct { text-align: right; font-variant-numeric: tabular-nums; color: var(--ink); } |
| .w3-toprow.observed .km { color: var(--ink); } |
| .w3-toprow.observed .fill { background: var(--amber); } |
| .w3-io { display: flex; align-items: flex-end; gap: 18px; flex-wrap: wrap; margin-top: 6px; } |
| .w3-io__group { display: flex; flex-direction: column; gap: 6px; } |
| .w3-io__lab { |
| font-family: "JetBrains Mono", monospace; |
| font-size: 9.5px; letter-spacing: 1.6px; text-transform: uppercase; color: var(--ink-faint); |
| } |
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| |
| |
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| |
| |
| .fns-seq-input { |
| width: 120px; |
| text-align: center; |
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| } |
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| font-family: "JetBrains Mono", monospace; |
| padding: 10px 0 6px; |
| } |
| .fns-truth, .fns-row { |
| display: grid; |
| grid-template-columns: 222px repeat(6, 34px) 28px; |
| align-items: center; |
| column-gap: 7px; |
| min-width: 480px; |
| } |
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| .fns-row { margin: 12px 0; } |
| .fns-gtlabel { |
| font-family: "JetBrains Mono", monospace; |
| font-size: 10px; |
| font-weight: 400; |
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| } |
| .fns-eq { |
| font-size: 16px; |
| color: var(--ink); |
| text-align: right; |
| white-space: nowrap; |
| } |
| .fns-eq sub, .fns-eq sup { font-size: 11px; } |
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| .fns-bracket { |
| font-family: "Inter", sans-serif; |
| font-size: 34px; |
| font-weight: 200; |
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| color: var(--ink-soft); |
| vertical-align: middle; |
| transform: scaleX(0.7); |
| display: inline-block; |
| } |
| .fns-box { |
| width: 30px; height: 30px; |
| display: inline-flex; align-items: center; justify-content: center; |
| font-family: "JetBrains Mono", monospace; |
| font-size: 14px; font-weight: 600; |
| border-radius: 3px; border: 1px solid; |
| transition: background 0.15s, border-color 0.15s, color 0.15s; |
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| .fns-box.wild { opacity: 0.38; } |
| .fns-loss { |
| margin-top: 20px; |
| padding-top: 16px; |
| border-top: 1px solid var(--rule); |
| font-family: "JetBrains Mono", monospace; |
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| .fns-loss .fns-term { margin: 0 3px; white-space: nowrap; } |
| .fns-explain { |
| margin-top: 18px; |
| padding-top: 16px; |
| border-top: 1px solid var(--rule); |
| font-family: "Inter", sans-serif; |
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| font-family: "JetBrains Mono", monospace; |
| font-size: 12px; |
| color: var(--ink); |
| } |
| .fns-explain .mono sup, .fns-explain .mono sub { font-size: 9px; } |
| |
| |
| .stat-tile { |
| background: var(--soft-cream); |
| border: 1px solid var(--rule); |
| padding: 14px 16px; |
| text-align: left; |
| } |
| .stat-tile__label { |
| font-family: "JetBrains Mono", monospace; |
| font-size: 10px; color: var(--ink-soft); |
| text-transform: uppercase; letter-spacing: 1.6px; |
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| .stat-tile__value { |
| font-family: "JetBrains Mono", monospace; |
| font-size: 26px; font-weight: 500; |
| color: var(--ink); |
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| font-family: "JetBrains Mono", monospace; |
| font-size: 10px; color: var(--ink-soft); |
| margin-top: 4px; letter-spacing: 0.5px; |
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| |
| |
| .post-foot { |
| max-width: 760px; |
| margin: 64px auto 0; |
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| font-family: "JetBrains Mono", monospace; |
| font-size: 11px; color: var(--ink-soft); |
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| } |
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| .post-foot a:hover { color: var(--green); } |
| |
| |
| .seq-track { |
| font-family: "JetBrains Mono", monospace; |
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| background: var(--soft-cream); |
| border: 1px solid var(--rule); |
| padding: 10px 12px; |
| display: flex; flex-wrap: wrap; gap: 1px; |
| user-select: none; |
| } |
| .seq-track__b { |
| display: inline-flex; align-items: center; justify-content: center; |
| width: 22px; height: 26px; |
| cursor: pointer; |
| border-radius: 2px; |
| color: #fff; |
| font-weight: 500; |
| transition: transform 0.1s ease, box-shadow 0.1s ease; |
| } |
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| .seq-track__b.T { background: var(--base-t); } |
| .seq-track__b.C { background: var(--base-c); } |
| .seq-track__b.G { background: var(--base-g); } |
| .seq-track__b.selected { |
| box-shadow: 0 0 0 2px var(--ink), 0 0 0 4px var(--bg); |
| } |
| |
| |
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| .b-T { color: var(--base-t); } |
| .b-C { color: var(--base-c); } |
| .b-G { color: var(--base-g); } |
| |
| |
| .kmer-token, .raw-seq { |
| font-family: "JetBrains Mono", monospace; |
| font-size: 12px; |
| font-weight: 500; |
| letter-spacing: 0.5px; |
| } |
| .kmer-token { |
| display: inline-flex; |
| align-items: center; |
| padding: 2px 0; |
| white-space: nowrap; |
| } |
| .kmer-token .br { color: var(--ink-faint); font-weight: 400; } |
| .kmer-token.muted { opacity: 0.45; } |
| .raw-seq { display: inline-flex; padding: 2px 0; } |
| |
| .bpe-flow { |
| display: flex; align-items: center; flex-wrap: wrap; |
| gap: 18px; |
| margin: 10px 0 8px; |
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| |
| |
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| grid-template-rows: auto 150px; |
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| display: grid; |
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| |
| |
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| } |
| .formula { |
| font-family: "JetBrains Mono", monospace; |
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| |
| |
| |
| |
| |
| body { padding: 20px 24px; background: #fff; } |
| .widget { max-width: 880px; margin: 0 auto; padding: 0; border: 0; } |
| .widget__head, .widget__caption { display: none; } |
| </style> |
| </head> |
| <body> |
| <aside class="widget" id="widget-06"> |
| <div class="widget__head"> |
| <span class="widget__eyebrow">§ Widget · 06</span> |
| <span class="widget__title">Perturbation Impact on HBB Gene Scores</span> |
| </div> |
| <p class="widget__caption"> |
| Comparing per-position scores before and after introducing a 30bp perturbation (positions 750–780) in the human hemoglobin beta (HBB) gene sequence. |
| The original sequence shows baseline model predictions, while the perturbed version reveals how local sequence changes propagate through the model's scoring. |
| Blue-highlighted regions mark the three coding sequence (CDS) exons. The visualization demonstrates both local effects within the perturbed region |
| and potential downstream impacts on score distributions across the gene. |
| </p> |
| <div class="demo"> |
| |
| <div style="position: relative;"> |
| <canvas id="hbb-canvas" width="1200" height="400" style="width: 100%; height: auto; display: block; cursor: crosshair;"></canvas> |
| <div id="hbb-tooltip" style="position: absolute; background: rgba(0,0,0,0.8); color: white; padding: 0.5rem; border-radius: 4px; font-size: 0.875rem; pointer-events: none; display: none; white-space: nowrap;"></div> |
| </div> |
|
|
| |
| <div style="margin-top: 2rem; padding-top: 1rem; border-top: 1px solid var(--rule);"> |
| <div style="font-family: 'JetBrains Mono', monospace; font-size: 11px; font-weight: 500; letter-spacing: 1.6px; text-transform: uppercase; color: var(--ink-soft); margin-bottom: 0.5rem;"> |
| Score Difference (Original - Perturbed) |
| </div> |
| <div style="position: relative;"> |
| <canvas id="hbb-diff-canvas" width="1200" height="400" style="width: 100%; height: auto; display: block; cursor: crosshair;"></canvas> |
| <div id="hbb-diff-tooltip" style="position: absolute; background: rgba(0,0,0,0.8); color: white; padding: 0.5rem; border-radius: 4px; font-size: 0.875rem; pointer-events: none; display: none; white-space: nowrap;"></div> |
| </div> |
| </div> |
|
|
| |
| <div style="margin-top: 2rem; padding-top: 1rem; border-top: 1px solid var(--rule); font-size: 0.875rem; color: var(--fg-dim);"> |
| <div style="display: flex; gap: 1.5rem; align-items: center; flex-wrap: wrap;"> |
| <div style="display: flex; align-items: center; gap: 0.5rem;"> |
| <div style="width: 20px; height: 3px; background: #317f3f;"></div> |
| <span>Original Scores</span> |
| </div> |
| <div style="display: flex; align-items: center; gap: 0.5rem;"> |
| <div style="width: 20px; height: 3px; background: #b8862c;"></div> |
| <span>Perturbed Scores</span> |
| </div> |
| <div style="display: flex; align-items: center; gap: 0.5rem;"> |
| <div style="width: 20px; height: 3px; background: #4a4a4a;"></div> |
| <span>Score Difference</span> |
| </div> |
| <div style="display: flex; align-items: center; gap: 0.5rem;"> |
| <div style="width: 20px; height: 12px; background: rgba(59, 130, 246, 0.2);"></div> |
| <span>CDS regions</span> |
| </div> |
| <div style="display: flex; align-items: center; gap: 0.5rem;"> |
| <div style="width: 20px; height: 12px; background: rgba(184, 134, 44, 0.15); border: 2px solid rgba(184, 134, 44, 0.6);"></div> |
| <span>Perturbed region (750-780)</span> |
| </div> |
| </div> |
| <div style="margin-top: 0.5rem;"> |
| <span id="hbb-stats">Loading...</span> |
| </div> |
| <div style="margin-top: 0.5rem;"> |
| <span id="hbb-loglik">Loading...</span> |
| </div> |
| </div> |
| </div> |
| </aside> |
| <script> |
| |
| |
| |
| (async function() { |
| const canvas = document.getElementById('hbb-canvas'); |
| const tooltip = document.getElementById('hbb-tooltip'); |
| const statsEl = document.getElementById('hbb-stats'); |
| const loglikEl = document.getElementById('hbb-loglik'); |
| |
| if (!canvas) return; |
| |
| const ctx = canvas.getContext('2d'); |
| const dpr = window.devicePixelRatio || 1; |
| |
| |
| const cdsRegions = [ |
| { start: 551, end: 642 }, |
| { start: 773, end: 995 }, |
| { start: 1846, end: 1974 } |
| ]; |
| |
| |
| const perturbedRegion = { start: 750, end: 780 }; |
| |
| |
| |
| const numPositions = 2500; |
| const original_scores = [0.251, 0.288, 0.367, 0.159, 0.167, 0.286, 0.278, 0.33, 0.329, 0.31, 0.309, 0.184, 0.197, 0.389, 0.176, 0.341, 0.328, 0.181, 0.383, 0.258, 0.396, 0.278, 0.197, 0.155, 0.4, 0.352, 0.319, 0.185, 0.321, 0.317, 0.12, 0.145, 0.187, 0.355, 0.189, 0.193, 0.237, 0.375, 0.222, 0.326, 0.209, 0.287, 0.361, 0.326, 0.29, 0.16, 0.317, 0.304, 0.17, 0.175, 0.285, 0.336, 0.332, 0.178, 0.375, 0.199, 0.363, 0.21, 0.19, 0.333, 0.235, 0.366, 0.268, 0.267, 0.193, 0.322, 0.256, 0.313, 0.312, 0.318, 0.31, 0.195, 0.185, 0.326, 0.347, 0.298, 0.363, 0.362, 0.162, 0.384, 0.157, 0.161, 0.314, 0.169, 0.335, 0.19, 0.192, 0.159, 0.303, 0.202, 0.224, 0.313, 0.304, 0.202, 0.3, 0.207, 0.376, 0.253, 0.148, 0.157, 0.315, 0.275, 0.185, 0.369, 0.295, 0.201, 0.306, 0.325, 0.221, 0.378, 0.188, 0.205, 0.185, 0.297, 0.239, 0.311, 0.221, 0.222, 0.307, 0.194, 0.278, 0.314, 0.303, 0.316, 0.288, 0.307, 0.196, 0.144, 0.327, 0.285, 0.183, 0.299, 0.134, 0.375, 0.315, 0.313, 0.329, 0.171, 0.312, 0.183, 0.294, 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| |
| |
| const minScore = Math.min(...original_scores, ...perturbed_scores); |
| const maxScore = Math.max(...original_scores, ...perturbed_scores); |
| |
| const avgOriginal = original_scores.reduce((a, b) => a + b, 0) / original_scores.length; |
| const avgPerturbed = perturbed_scores.reduce((a, b) => a + b, 0) / perturbed_scores.length; |
| |
| |
| const logLikOriginal = original_scores.reduce((sum, score) => sum + Math.log(score), 0); |
| const logLikPerturbed = perturbed_scores.reduce((sum, score) => sum + Math.log(score), 0); |
| |
| statsEl.innerHTML = `<b>${numPositions.toLocaleString()}</b> positions · ` + |
| `Original avg: <b>${avgOriginal.toFixed(3)}</b> · ` + |
| `Perturbed avg: <b>${avgPerturbed.toFixed(3)}</b>`; |
| |
| loglikEl.innerHTML = `Log Likelihood · Original: <b>${logLikOriginal.toFixed(2)}</b> · ` + |
| `Perturbed: <b>${logLikPerturbed.toFixed(2)}</b> · ` + |
| `Difference: <b>${(logLikOriginal - logLikPerturbed).toFixed(2)}</b>`; |
| |
| |
| function movingAverage(data, windowSize) { |
| const result = []; |
| for (let i = 0; i < data.length; i++) { |
| let sum = 0; |
| let count = 0; |
| const halfWindow = Math.floor(windowSize / 2); |
| |
| for (let j = Math.max(0, i - halfWindow); j <= Math.min(data.length - 1, i + halfWindow); j++) { |
| sum += data[j]; |
| count++; |
| } |
| result.push(sum / count); |
| } |
| return result; |
| } |
| |
| const smoothedOriginal = movingAverage(original_scores, 10); |
| const smoothedPerturbed = movingAverage(perturbed_scores, 10); |
| |
| |
| function draw() { |
| const w = canvas.width; |
| const h = canvas.height; |
| |
| |
| ctx.clearRect(0, 0, w, h); |
| |
| |
| const marginLeft = 60; |
| const marginRight = 20; |
| const marginTop = 20; |
| const marginBottom = 40; |
| const plotWidth = w - marginLeft - marginRight; |
| const plotHeight = h - marginTop - marginBottom; |
| |
| |
| ctx.fillStyle = 'rgba(59, 130, 246, 0.1)'; |
| for (const region of cdsRegions) { |
| const x1 = marginLeft + (region.start / numPositions) * plotWidth; |
| const x2 = marginLeft + ((region.end + 1) / numPositions) * plotWidth; |
| ctx.fillRect(x1, marginTop, x2 - x1, plotHeight); |
| } |
| |
| |
| ctx.fillStyle = 'rgba(184, 134, 44, 0.15)'; |
| const pertX1 = marginLeft + (perturbedRegion.start / numPositions) * plotWidth; |
| const pertX2 = marginLeft + ((perturbedRegion.end + 1) / numPositions) * plotWidth; |
| ctx.fillRect(pertX1, marginTop, pertX2 - pertX1, plotHeight); |
| |
| |
| ctx.strokeStyle = 'rgba(184, 134, 44, 0.6)'; |
| ctx.lineWidth = 2; |
| ctx.strokeRect(pertX1, marginTop, pertX2 - pertX1, plotHeight); |
| |
| |
| ctx.strokeStyle = '#666'; |
| ctx.lineWidth = 1; |
| ctx.beginPath(); |
| ctx.moveTo(marginLeft, marginTop); |
| ctx.lineTo(marginLeft, marginTop + plotHeight); |
| ctx.lineTo(marginLeft + plotWidth, marginTop + plotHeight); |
| ctx.stroke(); |
| |
| |
| ctx.fillStyle = '#666'; |
| ctx.font = '12px monospace'; |
| ctx.textAlign = 'right'; |
| ctx.textBaseline = 'middle'; |
| const yTicks = 5; |
| for (let i = 0; i <= yTicks; i++) { |
| const score = minScore + (maxScore - minScore) * (i / yTicks); |
| const y = marginTop + plotHeight - (i / yTicks) * plotHeight; |
| ctx.fillText(score.toFixed(1), marginLeft - 10, y); |
| |
| |
| ctx.strokeStyle = 'rgba(128, 128, 128, 0.1)'; |
| ctx.beginPath(); |
| ctx.moveTo(marginLeft, y); |
| ctx.lineTo(marginLeft + plotWidth, y); |
| ctx.stroke(); |
| } |
| |
| |
| ctx.textAlign = 'center'; |
| ctx.textBaseline = 'top'; |
| ctx.fillStyle = '#666'; |
| const xTicks = 5; |
| for (let i = 0; i <= xTicks; i++) { |
| const pos = Math.floor((i / xTicks) * numPositions); |
| const x = marginLeft + (i / xTicks) * plotWidth; |
| ctx.fillText(pos.toLocaleString(), x, marginTop + plotHeight + 10); |
| } |
| |
| |
| ctx.save(); |
| ctx.translate(0, marginTop + plotHeight / 2); |
| ctx.rotate(-Math.PI / 2); |
| ctx.textAlign = 'center'; |
| ctx.textBaseline = 'top'; |
| ctx.fillStyle = '#666'; |
| ctx.font = '14px sans-serif'; |
| ctx.fillText('Score', 0, 0); |
| ctx.restore(); |
| |
| ctx.textAlign = 'center'; |
| ctx.textBaseline = 'top'; |
| ctx.fillText('Position', marginLeft + plotWidth / 2, marginTop + plotHeight + 25); |
| |
| |
| ctx.strokeStyle = '#317f3f'; |
| ctx.lineWidth = 2; |
| ctx.beginPath(); |
| for (let i = 0; i < numPositions; i++) { |
| const x = marginLeft + (i / numPositions) * plotWidth; |
| const y = marginTop + plotHeight - ((smoothedOriginal[i] - minScore) / (maxScore - minScore)) * plotHeight; |
| if (i === 0) ctx.moveTo(x, y); |
| else ctx.lineTo(x, y); |
| } |
| ctx.stroke(); |
| |
| |
| ctx.strokeStyle = '#b8862c'; |
| ctx.lineWidth = 2; |
| ctx.beginPath(); |
| for (let i = 0; i < numPositions; i++) { |
| const x = marginLeft + (i / numPositions) * plotWidth; |
| const y = marginTop + plotHeight - ((smoothedPerturbed[i] - minScore) / (maxScore - minScore)) * plotHeight; |
| if (i === 0) ctx.moveTo(x, y); |
| else ctx.lineTo(x, y); |
| } |
| ctx.stroke(); |
| |
| |
| ctx.fillStyle = 'rgba(49, 127, 63, 0.3)'; |
| for (let i = 0; i < numPositions; i++) { |
| const x = marginLeft + (i / numPositions) * plotWidth; |
| const y = marginTop + plotHeight - ((original_scores[i] - minScore) / (maxScore - minScore)) * plotHeight; |
| ctx.beginPath(); |
| ctx.arc(x, y, 1.5, 0, 2 * Math.PI); |
| ctx.fill(); |
| } |
| |
| |
| ctx.fillStyle = 'rgba(184, 134, 44, 0.3)'; |
| for (let i = 0; i < numPositions; i++) { |
| const x = marginLeft + (i / numPositions) * plotWidth; |
| const y = marginTop + plotHeight - ((perturbed_scores[i] - minScore) / (maxScore - minScore)) * plotHeight; |
| ctx.beginPath(); |
| ctx.arc(x, y, 1.5, 0, 2 * Math.PI); |
| ctx.fill(); |
| } |
| } |
| |
| |
| draw(); |
| |
| |
| let mousePos = null; |
| |
| canvas.addEventListener('mousemove', (e) => { |
| const rect = canvas.getBoundingClientRect(); |
| const scaleX = canvas.width / rect.width; |
| const scaleY = canvas.height / rect.height; |
| const x = (e.clientX - rect.left) * scaleX; |
| const y = (e.clientY - rect.top) * scaleY; |
| |
| const marginLeft = 60; |
| const marginRight = 20; |
| const marginTop = 20; |
| const marginBottom = 40; |
| const plotWidth = canvas.width - marginLeft - marginRight; |
| const plotHeight = canvas.height - marginTop - marginBottom; |
| |
| |
| if (x >= marginLeft && x <= marginLeft + plotWidth && |
| y >= marginTop && y <= marginTop + plotHeight) { |
| const pos = Math.floor(((x - marginLeft) / plotWidth) * numPositions); |
| if (pos >= 0 && pos < numPositions) { |
| mousePos = pos; |
| |
| |
| let inCds = false; |
| for (const region of cdsRegions) { |
| if (pos >= region.start && pos <= region.end) { |
| inCds = true; |
| break; |
| } |
| } |
| |
| |
| const inPerturbed = pos >= perturbedRegion.start && pos <= perturbedRegion.end; |
| |
| |
| let tooltipHTML = `Position: <b>${pos}</b><br>Original: <b>${original_scores[pos].toFixed(4)}</b><br>Perturbed: <b>${perturbed_scores[pos].toFixed(4)}</b>`; |
| if (inCds) tooltipHTML += '<br><span style="color: #3b82f6;">CDS</span>'; |
| if (inPerturbed) tooltipHTML += '<br><span style="color: #b8862c;">Perturbed Region</span>'; |
| |
| tooltip.style.display = 'block'; |
| tooltip.style.left = e.clientX + 10 + 'px'; |
| tooltip.style.top = e.clientY + 10 + 'px'; |
| tooltip.innerHTML = tooltipHTML; |
| } |
| } else { |
| mousePos = null; |
| tooltip.style.display = 'none'; |
| } |
| }); |
| |
| canvas.addEventListener('mouseleave', () => { |
| mousePos = null; |
| tooltip.style.display = 'none'; |
| }); |
| |
| |
| window.addEventListener('resize', draw); |
| })(); |
| |
| |
| |
| |
| (async function() { |
| const canvas = document.getElementById('hbb-diff-canvas'); |
| const tooltip = document.getElementById('hbb-diff-tooltip'); |
| |
| if (!canvas) return; |
| |
| const ctx = canvas.getContext('2d'); |
| |
| |
| const numPositions = 2500; |
| |
| const scriptContent = document.scripts[document.scripts.length - 1].textContent; |
| |
| |
| const original_scores = [0.251, 0.288, 0.367, 0.159, 0.167, 0.286, 0.278, 0.33, 0.329, 0.31, 0.309, 0.184, 0.197, 0.389, 0.176, 0.341, 0.328, 0.181, 0.383, 0.258, 0.396, 0.278, 0.197, 0.155, 0.4, 0.352, 0.319, 0.185, 0.321, 0.317, 0.12, 0.145, 0.187, 0.355, 0.189, 0.193, 0.237, 0.375, 0.222, 0.326, 0.209, 0.287, 0.361, 0.326, 0.29, 0.16, 0.317, 0.304, 0.17, 0.175, 0.285, 0.336, 0.332, 0.178, 0.375, 0.199, 0.363, 0.21, 0.19, 0.333, 0.235, 0.366, 0.268, 0.267, 0.193, 0.322, 0.256, 0.313, 0.312, 0.318, 0.31, 0.195, 0.185, 0.326, 0.347, 0.298, 0.363, 0.362, 0.162, 0.384, 0.157, 0.161, 0.314, 0.169, 0.335, 0.19, 0.192, 0.159, 0.303, 0.202, 0.224, 0.313, 0.304, 0.202, 0.3, 0.207, 0.376, 0.253, 0.148, 0.157, 0.315, 0.275, 0.185, 0.369, 0.295, 0.201, 0.306, 0.325, 0.221, 0.378, 0.188, 0.205, 0.185, 0.297, 0.239, 0.311, 0.221, 0.222, 0.307, 0.194, 0.278, 0.314, 0.303, 0.316, 0.288, 0.307, 0.196, 0.144, 0.327, 0.285, 0.183, 0.299, 0.134, 0.375, 0.315, 0.313, 0.329, 0.171, 0.312, 0.183, 0.294, 0.286, 0.185, 0.187, 0.328, 0.2, 0.313, 0.325, 0.317, 0.326, 0.21, 0.134, 0.37, 0.157, 0.184, 0.279, 0.271, 0.174, 0.283, 0.302, 0.187, 0.317, 0.351, 0.226, 0.312, 0.322, 0.308, 0.326, 0.414, 0.389, 0.163, 0.345, 0.171, 0.331, 0.222, 0.253, 0.345, 0.264, 0.286, 0.173, 0.373, 0.428, 0.333, 0.388, 0.336, 0.366, 0.303, 0.243, 0.165, 0.287, 0.273, 0.371, 0.391, 0.099, 0.152, 0.351, 0.284, 0.17, 0.602, 0.32, 0.17, 0.476, 0.49, 0.247, 0.274, 0.614, 0.074, 0.367, 0.424, 0.613, 0.059, 0.443, 0.358, 0.541, 0.29, 0.096, 0.16, 0.34, 0.083, 0.264, 0.121, 0.479, 0.304, 0.264, 0.177, 0.148, 0.198, 0.208, 0.353, 0.317, 0.249, 0.456, 0.335, 0.281, 0.151, 0.165, 0.371, 0.317, 0.32, 0.32, 0.344, 0.325, 0.167, 0.344, 0.155, 0.329, 0.378, 0.154, 0.171, 0.336, 0.328, 0.324, 0.186, 0.18, 0.337, 0.161, 0.153, 0.344, 0.202, 0.232, 0.297, 0.29, 0.289, 0.307, 0.319, 0.322, 0.166, 0.368, 0.306, 0.179, 0.192, 0.348, 0.345, 0.329, 0.331, 0.321, 0.18, 0.345, 0.342, 0.149, 0.356, 0.169, 0.305, 0.321, 0.175, 0.171, 0.351, 0.321, 0.308, 0.151, 0.179, 0.185, 0.177, 0.151, 0.168, 0.298, 0.32, 0.236, 0.317, 0.217, 0.379, 0.254, 0.367, 0.276, 0.336, 0.291, 0.131, 0.434, 0.326, 0.305, 0.18, 0.311, 0.233, 0.184, 0.161, 0.334, 0.182, 0.184, 0.245, 0.118, 0.25, 0.241, 0.348, 0.235, 0.294, 0.245, 0.272, 0.271, 0.275, 0.253, 0.284, 0.306, 0.269, 0.303, 0.165, 0.152, 0.375, 0.274, 0.168, 0.295, 0.172, 0.19, 0.34, 0.254, 0.26, 0.21, 0.25, 0.222, 0.382, 0.218, 0.304, 0.219, 0.194, 0.214, 0.336, 0.228, 0.244, 0.251, 0.199, 0.251, 0.286, 0.169, 0.193, 0.324, 0.319, 0.236, 0.273, 0.33, 0.195, 0.322, 0.234, 0.242, 0.197, 0.346, 0.189, 0.262, 0.26, 0.188, 0.366, 0.303, 0.266, 0.21, 0.268, 0.261, 0.237, 0.248, 0.243, 0.288, 0.261, 0.27, 0.291, 0.277, 0.222, 0.233, 0.292, 0.225, 0.36, 0.225, 0.241, 0.232, 0.291, 0.212, 0.237, 0.238, 0.224, 0.242, 0.209, 0.251, 0.278, 0.21, 0.247, 0.245, 0.226, 0.24, 0.262, 0.266, 0.223, 0.241, 0.219, 0.227, 0.213, 0.252, 0.261, 0.251, 0.231, 0.239, 0.334, 0.207, 0.266, 0.238, 0.273, 0.237, 0.212, 0.276, 0.23, 0.227, 0.236, 0.276, 0.329, 0.222, 0.245, 0.201, 0.27, 0.263, 0.372, 0.232, 0.264, 0.273, 0.244, 0.239, 0.286, 0.197, 0.303, 0.285, 0.288, 0.274, 0.375, 0.189, 0.212, 0.297, 0.31, 0.293, 0.305, 0.226, 0.228, 0.306, 0.299, 0.305, 0.23, 0.289, 0.239, 0.24, 0.241, 0.251, 0.244, 0.265, 0.217, 0.221, 0.291, 0.262, 0.324, 0.301, 0.241, 0.239, 0.284, 0.272, 0.471, 0.229, 0.247, 0.283, 0.187, 0.226, 0.319, 0.191, 0.235, 0.208, 0.278, 0.272, 0.364, 0.25, 0.253, 0.274, 0.262, 0.25, 0.365, 0.341, 0.204, 0.253, 0.292, 0.3, 0.302, 0.324, 0.251, 0.238, 0.228, 0.249, 0.226, 0.252, 0.241, 0.217, 0.253, 0.254, 0.232, 0.233, 0.275, 0.266, 0.259, 0.271, 0.237, 0.26, 0.299, 0.205, 0.241, 0.263, 0.252, 0.275, 0.221, 0.28, 0.244, 0.241, 0.226, 0.293, 0.216, 0.283, 0.209, 0.299, 0.166, 0.369, 0.27, 0.243, 0.317, 0.275, 0.898, 0.231, 0.273, 0.327, 0.393, 0.229, 0.347, 0.67, 0.971, 0.935, 0.995, 0.987, 0.917, 0.458, 0.813, 0.763, 0.923, 0.795, 0.388, 0.94, 0.996, 0.842, 0.993, 0.988, 0.94, 0.137, 0.7, 0.809, 0.832, 0.883, 0.189, 0.746, 0.994, 0.05, 0.914, 0.819, 0.339, 0.739, 0.797, 0.906, 0.937, 0.999, 0.872, 0.999, 0.996, 0.997, 0.947, 0.865, 0.808, 0.994, 0.989, 0.809, 0.857, 0.997, 0.957, 0.992, 0.994, 0.126, 0.963, 0.989, 0.95, 0.973, 0.953, 0.819, 0.955, 0.983, 0.958, 0.956, 0.933, 0.941, 0.999, 0.999, 0.856, 0.993, 0.951, 0.81, 0.993, 0.996, 0.911, 0.962, 0.983, 0.853, 0.909, 1.0, 0.952, 0.987, 0.99, 0.914, 0.998, 0.999, 1.0, 0.999, 0.963, 0.975, 0.997, 0.975, 0.992, 0.981, 0.967, 0.101, 0.927, 0.932, 0.341, 0.43, 0.274, 0.304, 0.325, 0.571, 0.818, 0.876, 0.219, 0.855, 0.962, 0.892, 0.649, 0.195, 0.778, 0.635, 0.165, 0.689, 0.535, 0.493, 0.579, 0.333, 0.468, 0.036, 0.076, 0.304, 0.382, 0.206, 0.457, 0.222, 0.576, 0.48, 0.278, 0.085, 0.557, 0.482, 0.787, 0.861, 0.654, 0.715, 0.837, 0.675, 0.672, 0.714, 0.42, 0.509, 0.147, 0.467, 0.185, 0.173, 0.44, 0.381, 0.334, 0.258, 0.232, 0.55, 0.172, 0.088, 0.342, 0.162, 0.562, 0.487, 0.341, 0.349, 0.248, 0.277, 0.206, 0.772, 0.73, 0.808, 0.232, 0.28, 0.136, 0.946, 0.896, 0.802, 0.415, 0.478, 0.808, 0.975, 0.829, 0.953, 0.605, 0.537, 0.791, 0.547, 0.778, 0.693, 0.392, 0.846, 0.689, 0.193, 0.457, 0.755, 0.023, 0.509, 0.886, 0.647, 0.424, 0.091, 0.412, 0.589, 0.084, 0.398, 0.454, 0.193, 0.345, 0.548, 0.318, 0.421, 0.12, 0.35, 0.24, 0.349, 0.391, 0.281, 0.415, 0.496, 0.438, 0.406, 0.999, 0.812, 0.93, 0.999, 0.952, 0.987, 0.997, 0.1, 0.994, 0.994, 0.919, 0.999, 0.999, 0.927, 0.99, 0.999, 0.089, 0.999, 1.0, 1.0, 0.998, 0.998, 0.552, 0.994, 0.998, 0.969, 0.997, 0.995, 0.961, 0.999, 0.999, 0.96, 1.0, 0.999, 0.968, 0.995, 0.995, 0.066, 0.2, 0.419, 0.886, 0.998, 0.998, 0.944, 0.999, 0.999, 0.927, 0.977, 0.998, 0.053, 0.83, 0.999, 0.941, 0.986, 0.995, 0.853, 0.142, 0.981, 0.978, 0.071, 0.991, 0.877, 0.881, 0.82, 0.96, 0.993, 0.988, 0.931, 0.757, 0.999, 0.922, 0.98, 0.993, 0.86, 0.942, 0.944, 0.883, 0.997, 0.998, 0.615, 0.685, 0.987, 0.959, 0.978, 0.972, 0.841, 0.995, 0.999, 0.942, 0.999, 0.997, 0.97, 0.975, 0.978, 0.061, 0.998, 1.0, 0.854, 0.999, 0.993, 0.943, 0.994, 0.985, 0.974, 1.0, 0.999, 0.096, 0.998, 1.0, 0.954, 0.932, 0.998, 0.012, 0.76, 0.84, 0.752, 0.519, 0.997, 0.919, 0.982, 0.998, 0.848, 0.923, 0.918, 0.855, 0.938, 0.993, 0.91, 0.997, 0.99, 0.84, 0.934, 0.999, 0.612, 0.251, 0.359, 0.472, 0.983, 0.999, 0.441, 0.865, 0.999, 0.916, 0.967, 0.961, 0.814, 0.746, 0.979, 0.921, 0.992, 1.0, 0.965, 0.999, 0.997, 0.961, 0.978, 0.997, 0.855, 0.989, 0.995, 0.839, 0.997, 0.986, 0.97, 0.993, 0.997, 0.8, 0.094, 0.047, 0.083, 0.97, 1.0, 0.944, 1.0, 0.999, 0.923, 0.993, 0.998, 0.871, 0.988, 0.988, 0.926, 1.0, 1.0, 0.939, 0.998, 0.958, 0.912, 0.998, 0.998, 0.957, 0.995, 0.998, 0.922, 0.981, 1.0, 0.976, 0.999, 0.997, 0.373, 0.999, 1.0, 0.976, 1.0, 1.0, 0.975, 0.999, 1.0, 0.882, 0.998, 0.995, 0.964, 1.0, 0.999, 0.981, 1.0, 0.999, 0.945, 0.924, 0.579, 0.989, 0.997, 0.997, 0.895, 0.997, 0.998, 0.988, 0.568, 0.666, 0.265, 0.537, 0.893, 0.731, 0.382, 0.73, 0.462, 0.32, 0.687, 0.784, 0.235, 0.299, 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| const perturbed_scores = [0.251, 0.288, 0.367, 0.159, 0.167, 0.286, 0.278, 0.33, 0.329, 0.31, 0.309, 0.184, 0.197, 0.389, 0.176, 0.341, 0.328, 0.181, 0.383, 0.258, 0.396, 0.278, 0.197, 0.155, 0.4, 0.352, 0.319, 0.185, 0.321, 0.317, 0.12, 0.145, 0.187, 0.355, 0.189, 0.193, 0.237, 0.375, 0.222, 0.326, 0.209, 0.287, 0.361, 0.326, 0.29, 0.16, 0.317, 0.304, 0.17, 0.175, 0.285, 0.336, 0.332, 0.178, 0.375, 0.199, 0.363, 0.21, 0.19, 0.333, 0.235, 0.366, 0.268, 0.267, 0.193, 0.322, 0.256, 0.313, 0.312, 0.318, 0.31, 0.195, 0.185, 0.326, 0.347, 0.298, 0.363, 0.362, 0.162, 0.384, 0.157, 0.161, 0.314, 0.169, 0.335, 0.19, 0.192, 0.159, 0.303, 0.202, 0.224, 0.313, 0.304, 0.202, 0.3, 0.207, 0.376, 0.253, 0.148, 0.157, 0.315, 0.275, 0.185, 0.369, 0.295, 0.201, 0.306, 0.325, 0.221, 0.378, 0.188, 0.205, 0.185, 0.297, 0.239, 0.311, 0.221, 0.222, 0.307, 0.194, 0.278, 0.314, 0.303, 0.316, 0.288, 0.307, 0.196, 0.144, 0.327, 0.285, 0.183, 0.299, 0.134, 0.375, 0.315, 0.313, 0.329, 0.171, 0.312, 0.183, 0.294, 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0.309, 0.252, 0.33, 0.25, 0.333, 0.31, 0.172, 0.232, 0.332, 0.361, 0.239, 0.166, 0.259, 0.166, 0.256, 0.289, 0.322, 0.204, 0.208, 0.294, 0.196, 0.225, 0.32, 0.313, 0.305, 0.213, 0.218, 0.281, 0.235, 0.314, 0.187, 0.273, 0.265, 0.251, 0.298, 0.165, 0.308, 0.301, 0.225, 0.275, 0.348, 0.339, 0.216]; |
| |
| |
| const differences = []; |
| for (let i = 0; i < numPositions; i++) { |
| differences.push(original_scores[i] - perturbed_scores[i]); |
| } |
| |
| const minDiff = Math.min(...differences); |
| const maxDiff = Math.max(...differences); |
| |
| |
| const cdsRegions = [ |
| { start: 551, end: 642 }, |
| { start: 773, end: 995 }, |
| { start: 1846, end: 1974 } |
| ]; |
| const perturbedRegion = { start: 750, end: 780 }; |
| |
| |
| function movingAverage(data, windowSize) { |
| const result = []; |
| for (let i = 0; i < data.length; i++) { |
| let sum = 0; |
| let count = 0; |
| const halfWindow = Math.floor(windowSize / 2); |
| for (let j = Math.max(0, i - halfWindow); j <= Math.min(data.length - 1, i + halfWindow); j++) { |
| sum += data[j]; |
| count++; |
| } |
| result.push(sum / count); |
| } |
| return result; |
| } |
| |
| const smoothedDiff = movingAverage(differences, 10); |
| |
| |
| function draw() { |
| const w = canvas.width; |
| const h = canvas.height; |
| |
| ctx.clearRect(0, 0, w, h); |
| |
| const marginLeft = 60; |
| const marginRight = 20; |
| const marginTop = 20; |
| const marginBottom = 40; |
| const plotWidth = w - marginLeft - marginRight; |
| const plotHeight = h - marginTop - marginBottom; |
| |
| |
| ctx.fillStyle = 'rgba(59, 130, 246, 0.1)'; |
| for (const region of cdsRegions) { |
| const x1 = marginLeft + (region.start / numPositions) * plotWidth; |
| const x2 = marginLeft + ((region.end + 1) / numPositions) * plotWidth; |
| ctx.fillRect(x1, marginTop, x2 - x1, plotHeight); |
| } |
| |
| |
| ctx.fillStyle = 'rgba(184, 134, 44, 0.15)'; |
| const pertX1 = marginLeft + (perturbedRegion.start / numPositions) * plotWidth; |
| const pertX2 = marginLeft + ((perturbedRegion.end + 1) / numPositions) * plotWidth; |
| ctx.fillRect(pertX1, marginTop, pertX2 - pertX1, plotHeight); |
| ctx.strokeStyle = 'rgba(184, 134, 44, 0.6)'; |
| ctx.lineWidth = 2; |
| ctx.strokeRect(pertX1, marginTop, pertX2 - pertX1, plotHeight); |
| |
| |
| const yMin = -0.2; |
| const yMax = 0.8; |
| |
| |
| const zeroY = marginTop + plotHeight - ((0 - yMin) / (yMax - yMin)) * plotHeight; |
| ctx.strokeStyle = '#666'; |
| ctx.lineWidth = 1.5; |
| ctx.setLineDash([]); |
| ctx.beginPath(); |
| ctx.moveTo(marginLeft, zeroY); |
| ctx.lineTo(marginLeft + plotWidth, zeroY); |
| ctx.stroke(); |
| |
| |
| ctx.strokeStyle = '#666'; |
| ctx.lineWidth = 1; |
| ctx.beginPath(); |
| ctx.moveTo(marginLeft, marginTop); |
| ctx.lineTo(marginLeft, marginTop + plotHeight); |
| ctx.lineTo(marginLeft + plotWidth, marginTop + plotHeight); |
| ctx.stroke(); |
| |
| |
| ctx.fillStyle = '#666'; |
| ctx.font = '12px monospace'; |
| ctx.textAlign = 'right'; |
| ctx.textBaseline = 'middle'; |
| const yTickValues = [-0.2, 0, 0.2, 0.4, 0.6, 0.8]; |
| for (const tickValue of yTickValues) { |
| const y = marginTop + plotHeight - ((tickValue - yMin) / (yMax - yMin)) * plotHeight; |
| |
| |
| if (tickValue === 0) { |
| ctx.font = 'bold 12px monospace'; |
| ctx.fillText(tickValue.toFixed(1), marginLeft - 10, y); |
| ctx.font = '12px monospace'; |
| } else { |
| ctx.fillText(tickValue.toFixed(1), marginLeft - 10, y); |
| } |
| |
| |
| ctx.strokeStyle = 'rgba(128, 128, 128, 0.1)'; |
| ctx.beginPath(); |
| ctx.moveTo(marginLeft, y); |
| ctx.lineTo(marginLeft + plotWidth, y); |
| ctx.stroke(); |
| } |
| |
| |
| ctx.textAlign = 'center'; |
| ctx.textBaseline = 'top'; |
| ctx.fillStyle = '#666'; |
| const xTicks = 5; |
| for (let i = 0; i <= xTicks; i++) { |
| const pos = Math.floor((i / xTicks) * numPositions); |
| const x = marginLeft + (i / xTicks) * plotWidth; |
| ctx.fillText(pos.toLocaleString(), x, marginTop + plotHeight + 10); |
| } |
| |
| |
| ctx.save(); |
| ctx.translate(0, marginTop + plotHeight / 2); |
| ctx.rotate(-Math.PI / 2); |
| ctx.textAlign = 'center'; |
| ctx.textBaseline = 'top'; |
| ctx.fillStyle = '#666'; |
| ctx.font = '14px sans-serif'; |
| ctx.fillText('Score Difference', 0, 0); |
| ctx.restore(); |
| |
| ctx.textAlign = 'center'; |
| ctx.textBaseline = 'top'; |
| ctx.fillText('Position', marginLeft + plotWidth / 2, marginTop + plotHeight + 25); |
| |
| |
| ctx.strokeStyle = '#4a4a4a'; |
| ctx.lineWidth = 2; |
| ctx.beginPath(); |
| for (let i = 0; i < numPositions; i++) { |
| const x = marginLeft + (i / numPositions) * plotWidth; |
| const y = marginTop + plotHeight - ((smoothedDiff[i] - yMin) / (yMax - yMin)) * plotHeight; |
| if (i === 0) ctx.moveTo(x, y); |
| else ctx.lineTo(x, y); |
| } |
| ctx.stroke(); |
| |
| |
| ctx.fillStyle = 'rgba(74, 74, 74, 0.3)'; |
| for (let i = 0; i < numPositions; i++) { |
| const x = marginLeft + (i / numPositions) * plotWidth; |
| const y = marginTop + plotHeight - ((differences[i] - yMin) / (yMax - yMin)) * plotHeight; |
| ctx.beginPath(); |
| ctx.arc(x, y, 1.5, 0, 2 * Math.PI); |
| ctx.fill(); |
| } |
| } |
| |
| draw(); |
| |
| |
| let mousePos = null; |
| |
| canvas.addEventListener('mousemove', (e) => { |
| const rect = canvas.getBoundingClientRect(); |
| const scaleX = canvas.width / rect.width; |
| const scaleY = canvas.height / rect.height; |
| const x = (e.clientX - rect.left) * scaleX; |
| const y = (e.clientY - rect.top) * scaleY; |
| |
| const marginLeft = 60; |
| const marginRight = 20; |
| const marginTop = 20; |
| const marginBottom = 40; |
| const plotWidth = canvas.width - marginLeft - marginRight; |
| const plotHeight = canvas.height - marginTop - marginBottom; |
| |
| if (x >= marginLeft && x <= marginLeft + plotWidth && |
| y >= marginTop && y <= marginTop + plotHeight) { |
| const pos = Math.floor(((x - marginLeft) / plotWidth) * numPositions); |
| if (pos >= 0 && pos < numPositions) { |
| mousePos = pos; |
| |
| const inCds = cdsRegions.some(r => pos >= r.start && pos <= r.end); |
| const inPerturbed = pos >= perturbedRegion.start && pos <= perturbedRegion.end; |
| |
| let tooltipHTML = `Position: <b>${pos}</b><br>Difference: <b>${differences[pos].toFixed(4)}</b>`; |
| if (inCds) tooltipHTML += '<br><span style="color: #3b82f6;">CDS</span>'; |
| if (inPerturbed) tooltipHTML += '<br><span style="color: #b8862c;">Perturbed Region</span>'; |
| |
| tooltip.style.display = 'block'; |
| tooltip.style.left = e.clientX + 10 + 'px'; |
| tooltip.style.top = e.clientY + 10 + 'px'; |
| tooltip.innerHTML = tooltipHTML; |
| } |
| } else { |
| mousePos = null; |
| tooltip.style.display = 'none'; |
| } |
| }); |
| |
| canvas.addEventListener('mouseleave', () => { |
| mousePos = null; |
| tooltip.style.display = 'none'; |
| }); |
| |
| window.addEventListener('resize', draw); |
| })(); |
| </script> |
| </body> |
| </html> |
