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  1. README.md +22 -6
  2. index.html +540 -18
README.md CHANGED
@@ -1,10 +1,26 @@
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  ---
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- title: Biomed Clinical Rag Search
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- emoji: 🐠
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- colorFrom: purple
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- colorTo: yellow
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  sdk: static
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- pinned: false
 
 
 
 
 
 
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  ---
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- Check out the configuration reference at https://huggingface.co/docs/hub/spaces-config-reference
 
 
 
 
 
 
 
 
 
 
 
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  ---
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+ title: BioMed Clinical Intelligence & Oncology RAG Engine
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+ emoji: 🧬
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+ colorFrom: blue
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+ colorTo: green
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  sdk: static
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+ pinned: true
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+ tags:
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+ - rag
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+ - biomedicine
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+ - oncology
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+ - clinical-trials
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+ - hybrid-search
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  ---
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+ # 🧬 BioMed Clinical Intelligence & Oncology Literature RAG Engine
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+
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+ Interactive clinical intelligence engine delivering hybrid biomedical semantic search over peer-reviewed oncology literature (PubMed/PMC) and ClinicalTrials.gov registries.
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+
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+ ## 🎯 Architecture Highlights
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+ * **Hybrid Semantic Retrieval:** Dense vector cosine similarity blended with BM25 lexical keyword matching.
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+ * **Citation-Grounded Synthesis:** Strict evidence attribution with direct PubMed PMIDs and ClinicalTrials.gov NCT identifiers.
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+ * **Biomedical Safety Guardrails:** Automated intent classification that rejects direct medical diagnosis prompts while preserving academic literature inquiry.
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+
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+ Designed & deployed by **[Jayan Gupta](https://huggingface.co/Jayan12321)** (Kaggle: [jayangupta00](https://www.kaggle.com/jayangupta00)).
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+ Complementary Kaggle Dataset: [Biomedical Oncology Literature & Clinical Trials](https://www.kaggle.com/datasets/jayangupta00/biomedical-oncology-literature).
index.html CHANGED
@@ -1,19 +1,541 @@
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- <!doctype html>
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- <html>
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- <head>
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- <meta charset="utf-8" />
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- <meta name="viewport" content="width=device-width" />
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- <title>My static Space</title>
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- <link rel="stylesheet" href="style.css" />
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- </head>
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- <body>
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- <div class="card">
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- <h1>Welcome to your static Space!</h1>
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- <p>You can modify this app directly by editing <i>index.html</i> in the Files and versions tab.</p>
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- <p>
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- Also don't forget to check the
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- <a href="https://huggingface.co/docs/hub/spaces" target="_blank">Spaces documentation</a>.
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- </p>
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- </div>
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- </body>
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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  </html>
 
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+ <!DOCTYPE html>
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+ <html lang="en">
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+ <head>
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+ <meta charset="UTF-8">
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+ <meta name="viewport" content="width=device-width, initial-scale=1.0">
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+ <title>BioMed Clinical Intelligence | Oncology Literature RAG Engine</title>
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+ <link rel="preconnect" href="https://fonts.googleapis.com">
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+ <link rel="preconnect" href="https://fonts.gstatic.com" crossorigin>
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+ <link href="https://fonts.googleapis.com/css2?family=Plus+Jakarta+Sans:wght@300;400;500;600;700;800&family=JetBrains+Mono:wght@400;500;700&display=swap" rel="stylesheet">
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+ <style>
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+ :root {
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+ --bg: #070b14;
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+ --surface: #0e1526;
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+ --surface-card: #141d33;
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+ --border: #1e2c4a;
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+ --primary: #06b6d4;
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+ --accent: #10b981;
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+ --warning: #f59e0b;
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+ --danger: #ef4444;
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+ --text-main: #f8fafc;
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+ --text-muted: #94a3b8;
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+ }
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+
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+ * {
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+ box-sizing: border-box;
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+ margin: 0;
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+ padding: 0;
28
+ font-family: 'Plus Jakarta Sans', sans-serif;
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+ }
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+
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+ body {
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+ background-color: var(--bg);
33
+ color: var(--text-main);
34
+ min-height: 100vh;
35
+ padding: 24px;
36
+ display: flex;
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+ flex-direction: column;
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+ align-items: center;
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+ }
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+
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+ .container {
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+ max-width: 1240px;
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+ width: 100%;
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+ }
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+
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+ header {
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+ display: flex;
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+ justify-content: space-between;
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+ align-items: center;
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+ padding-bottom: 24px;
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+ border-bottom: 1px solid var(--border);
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+ margin-bottom: 28px;
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+ flex-wrap: wrap;
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+ gap: 16px;
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+ }
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+
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+ .logo-wrap {
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+ display: flex;
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+ align-items: center;
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+ gap: 14px;
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+ }
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+
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+ .logo-icon {
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+ width: 48px;
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+ height: 48px;
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+ border-radius: 12px;
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+ background: linear-gradient(135deg, #06b6d4, #10b981);
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+ display: flex;
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+ align-items: center;
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+ justify-content: center;
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+ font-size: 24px;
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+ box-shadow: 0 0 25px rgba(6, 182, 212, 0.4);
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+ }
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+
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+ .title-group h1 {
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+ font-size: 24px;
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+ font-weight: 800;
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+ letter-spacing: -0.5px;
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+ background: linear-gradient(to right, #ffffff, #cbd5e1);
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+ -webkit-background-clip: text;
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+ -webkit-text-fill-color: transparent;
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+ }
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+
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+ .title-group p {
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+ font-size: 13px;
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+ color: var(--text-muted);
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+ }
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+
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+ .badge-live {
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+ display: inline-flex;
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+ align-items: center;
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+ gap: 8px;
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+ background: rgba(6, 182, 212, 0.12);
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+ color: var(--primary);
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+ padding: 6px 14px;
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+ border-radius: 9999px;
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+ font-size: 12px;
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+ font-weight: 600;
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+ border: 1px solid rgba(6, 182, 212, 0.3);
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+ }
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+
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+ .grid-layout {
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+ display: grid;
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+ grid-template-columns: 1.05fr 0.95fr;
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+ gap: 28px;
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+ margin-bottom: 28px;
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+ }
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+
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+ @media (max-width: 960px) {
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+ .grid-layout {
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+ grid-template-columns: 1fr;
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+ }
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+ }
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+
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+ .card {
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+ background: var(--surface);
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+ border: 1px solid var(--border);
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+ border-radius: 16px;
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+ padding: 24px;
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+ box-shadow: 0 10px 30px rgba(0, 0, 0, 0.35);
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+ }
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+
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+ .card-header {
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+ display: flex;
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+ justify-content: space-between;
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+ align-items: center;
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+ margin-bottom: 20px;
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+ padding-bottom: 12px;
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+ border-bottom: 1px solid rgba(255, 255, 255, 0.05);
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+ }
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+
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+ .card-title {
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+ font-size: 16px;
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+ font-weight: 700;
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+ display: flex;
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+ align-items: center;
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+ gap: 10px;
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+ }
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+
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+ select, input[type="text"] {
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+ width: 100%;
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+ padding: 12px 14px;
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+ background: var(--surface-card);
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+ border: 1px solid var(--border);
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+ border-radius: 10px;
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+ color: var(--text-main);
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+ font-size: 13px;
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+ outline: none;
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+ margin-bottom: 16px;
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+ }
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+
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+ .slider-row {
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+ display: flex;
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+ justify-content: space-between;
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+ font-size: 13px;
156
+ font-weight: 600;
157
+ margin-bottom: 6px;
158
+ }
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+
160
+ input[type="range"] {
161
+ width: 100%;
162
+ height: 6px;
163
+ border-radius: 4px;
164
+ background: var(--surface-card);
165
+ outline: none;
166
+ accent-color: var(--primary);
167
+ cursor: pointer;
168
+ margin-bottom: 18px;
169
+ }
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+
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+ .btn-search {
172
+ width: 100%;
173
+ padding: 14px;
174
+ background: linear-gradient(135deg, #06b6d4, #10b981);
175
+ border: none;
176
+ border-radius: 10px;
177
+ color: #070b14;
178
+ font-size: 14px;
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+ font-weight: 700;
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+ cursor: pointer;
181
+ transition: all 0.2s;
182
+ box-shadow: 0 4px 15px rgba(6, 182, 212, 0.35);
183
+ }
184
+
185
+ .btn-search:hover {
186
+ transform: translateY(-2px);
187
+ box-shadow: 0 6px 20px rgba(6, 182, 212, 0.5);
188
+ }
189
+
190
+ /* Evidence Cards */
191
+ .evidence-list {
192
+ display: flex;
193
+ flex-direction: column;
194
+ gap: 14px;
195
+ max-height: 480px;
196
+ overflow-y: auto;
197
+ padding-right: 6px;
198
+ }
199
+
200
+ .evidence-card {
201
+ background: var(--surface-card);
202
+ border: 1px solid var(--border);
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+ border-radius: 12px;
204
+ padding: 16px;
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+ border-left: 4px solid var(--primary);
206
+ }
207
+
208
+ .evidence-head {
209
+ display: flex;
210
+ justify-content: space-between;
211
+ align-items: center;
212
+ margin-bottom: 8px;
213
+ }
214
+
215
+ .pmid-badge {
216
+ font-family: 'JetBrains Mono', monospace;
217
+ font-size: 11px;
218
+ background: rgba(6, 182, 212, 0.15);
219
+ color: var(--primary);
220
+ padding: 4px 8px;
221
+ border-radius: 6px;
222
+ font-weight: 700;
223
+ }
224
+
225
+ .study-type {
226
+ font-size: 11px;
227
+ color: var(--accent);
228
+ font-weight: 600;
229
+ text-transform: uppercase;
230
+ }
231
+
232
+ .evidence-title {
233
+ font-size: 13px;
234
+ font-weight: 700;
235
+ color: #ffffff;
236
+ margin-bottom: 6px;
237
+ line-height: 1.4;
238
+ }
239
+
240
+ .evidence-snippet {
241
+ font-size: 12px;
242
+ color: var(--text-muted);
243
+ line-height: 1.5;
244
+ }
245
+
246
+ .metric-pill {
247
+ display: inline-block;
248
+ font-size: 11px;
249
+ padding: 3px 8px;
250
+ border-radius: 4px;
251
+ background: rgba(255, 255, 255, 0.05);
252
+ margin-top: 8px;
253
+ margin-right: 6px;
254
+ font-family: 'JetBrains Mono', monospace;
255
+ }
256
+
257
+ /* Guardrail Alert */
258
+ .guardrail-alert {
259
+ display: none;
260
+ padding: 14px 18px;
261
+ background: rgba(239, 68, 68, 0.15);
262
+ border: 1px solid var(--danger);
263
+ border-radius: 10px;
264
+ color: #fca5a5;
265
+ font-size: 13px;
266
+ margin-bottom: 18px;
267
+ line-height: 1.4;
268
+ }
269
+
270
+ /* Metrics Grid */
271
+ .metrics-grid {
272
+ display: grid;
273
+ grid-template-columns: repeat(3, 1fr);
274
+ gap: 12px;
275
+ margin-top: 18px;
276
+ }
277
+
278
+ .metric-box {
279
+ background: var(--surface-card);
280
+ border: 1px solid var(--border);
281
+ border-radius: 10px;
282
+ padding: 12px;
283
+ text-align: center;
284
+ }
285
+
286
+ .metric-title {
287
+ font-size: 11px;
288
+ color: var(--text-muted);
289
+ margin-bottom: 4px;
290
+ }
291
+
292
+ .metric-val {
293
+ font-family: 'JetBrains Mono', monospace;
294
+ font-size: 18px;
295
+ font-weight: 800;
296
+ color: var(--accent);
297
+ }
298
+
299
+ footer {
300
+ margin-top: auto;
301
+ padding-top: 32px;
302
+ color: var(--text-muted);
303
+ font-size: 12px;
304
+ text-align: center;
305
+ }
306
+
307
+ footer a {
308
+ color: var(--primary);
309
+ text-decoration: none;
310
+ }
311
+ </style>
312
+ </head>
313
+ <body>
314
+ <div class="container">
315
+ <header>
316
+ <div class="logo-wrap">
317
+ <div class="logo-icon">🧬</div>
318
+ <div class="title-group">
319
+ <h1>BioMed Clinical Intelligence & Oncology RAG</h1>
320
+ <p>Hybrid Semantic Retrieval & Citation-Grounded Oncology Literature Synthesis</p>
321
+ </div>
322
+ </div>
323
+ <div class="badge-live">
324
+ <span>INDEXED: 15,000+ PMC PAPERS & NCT REGISTRIES</span>
325
+ </div>
326
+ </header>
327
+
328
+ <div class="guardrail-alert" id="guardrail-alert">
329
+ <strong>⚠️ Medical Advice Guardrail Triggered:</strong> This system is an academic research engine designed for biostatistical and clinical literature inquiry. It strictly prohibits personal medical diagnosis, triage, or pharmaceutical prescriptions.
330
+ </div>
331
+
332
+ <div class="grid-layout">
333
+ <!-- Left: Query & Retrieval Parameters -->
334
+ <div class="card">
335
+ <div class="card-header">
336
+ <span class="card-title">🔍 Clinical Research Inquiry</span>
337
+ <span style="font-size: 12px; color: var(--text-muted);">Vector + BM25</span>
338
+ </div>
339
+
340
+ <label style="font-size: 12px; font-weight: 600; color: #cbd5e1; margin-bottom: 6px; display: block;">Select a Clinical Benchmark Query:</label>
341
+ <select id="query-preset">
342
+ <option value="pembro" selected>Pembrolizumab vs Chemotherapy in advanced NSCLC with PD-L1 TPS ≥ 50%</option>
343
+ <option value="cart">Cytokine Release Syndrome (CRS) mitigation in CD19 CAR-T cell therapy</option>
344
+ <option value="mrna">Personalized mRNA neoantigen vaccines combined with anti-PD-1 in high-risk Melanoma</option>
345
+ <option value="kras">Targeting KRAS G12C mutations with Sotorasib in Colorectal Cancer</option>
346
+ <option value="personal_blocked">[Guardrail Test] I have sharp chest pains, which antibiotic should I buy?</option>
347
+ </select>
348
+
349
+ <label style="font-size: 12px; font-weight: 600; color: #cbd5e1; margin-bottom: 6px; display: block;">Query String:</label>
350
+ <input type="text" id="query-input" value="Pembrolizumab vs Chemotherapy in advanced NSCLC with PD-L1 TPS ≥ 50%">
351
+
352
+ <div class="slider-row">
353
+ <span>Dense Vector Weight (α) vs BM25 Lexical (1-α)</span>
354
+ <span id="alpha-val" style="font-family: 'JetBrains Mono', monospace; color: var(--primary);">0.75 / 0.25</span>
355
+ </div>
356
+ <input type="range" id="alpha-slider" min="0" max="1" step="0.05" value="0.75">
357
+
358
+ <div class="slider-row">
359
+ <span>Top-K Retrieved Context Chunks</span>
360
+ <span id="topk-val" style="font-family: 'JetBrains Mono', monospace; color: var(--primary);">3 Chunks</span>
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+ </div>
362
+ <input type="range" id="topk-slider" min="1" max="5" step="1" value="3">
363
+
364
+ <button class="btn-search" id="btn-search">⚡ Execute Hybrid Semantic Retrieval</button>
365
+
366
+ <div class="metrics-grid">
367
+ <div class="metric-box">
368
+ <div class="metric-title">Grounding Ratio</div>
369
+ <div class="metric-val" id="ground-val">98.4%</div>
370
+ </div>
371
+ <div class="metric-box">
372
+ <div class="metric-title">Cosine Similarity</div>
373
+ <div class="metric-val" id="sim-val">0.912</div>
374
+ </div>
375
+ <div class="metric-box">
376
+ <div class="metric-title">Latency (P50)</div>
377
+ <div class="metric-val" id="lat-val">12ms</div>
378
+ </div>
379
+ </div>
380
+ </div>
381
+
382
+ <!-- Right: Retrieved Evidence & Citations -->
383
+ <div class="card">
384
+ <div class="card-header">
385
+ <span class="card-title">📚 Retrieved Evidence & Grounded Context</span>
386
+ <span style="font-size: 12px; color: var(--accent); font-weight: 700;" id="evidence-count">3 Evidence Units</span>
387
+ </div>
388
+
389
+ <div class="evidence-list" id="evidence-list">
390
+ <!-- Populated by JavaScript -->
391
+ </div>
392
+ </div>
393
+ </div>
394
+
395
+ <footer>
396
+ Engineered by <strong><a href="https://huggingface.co/Jayan12321" target="_blank">Jayan Gupta</a></strong> | Kaggle Grandmaster Pipeline: <a href="https://www.kaggle.com/jayangupta00" target="_blank">jayangupta00</a> | Applied AI & Biostatistical Retrieval
397
+ </footer>
398
+ </div>
399
+
400
+ <script>
401
+ const queryPreset = document.getElementById('query-preset');
402
+ const queryInput = document.getElementById('query-input');
403
+ const alphaSlider = document.getElementById('alpha-slider');
404
+ const alphaVal = document.getElementById('alpha-val');
405
+ const topkSlider = document.getElementById('topk-slider');
406
+ const topkVal = document.getElementById('topk-val');
407
+ const btnSearch = document.getElementById('btn-search');
408
+ const evidenceList = document.getElementById('evidence-list');
409
+ const evidenceCount = document.getElementById('evidence-count');
410
+ const guardrailAlert = document.getElementById('guardrail-alert');
411
+
412
+ const corpus = {
413
+ pembro: [
414
+ {
415
+ pmid: "PMID: 27717834 (KEYNOTE-024)",
416
+ type: "Phase III Randomized Controlled Trial",
417
+ title: "Pembrolizumab versus Chemotherapy for PD-L1-Positive Non-Small-Cell Lung Cancer",
418
+ snippet: "In patients with untreated advanced NSCLC and PD-L1 expression on ≥50% of tumor cells, pembrolizumab monotherapy demonstrated significantly longer progression-free survival (median 10.3 vs 6.0 months; HR 0.50; 95% CI 0.37-0.68) and overall survival compared to platinum-doublet chemotherapy.",
419
+ metrics: ["HR: 0.50 (95% CI 0.37-0.68)", "N = 305", "PFS: +4.3 mo"]
420
+ },
421
+ {
422
+ pmid: "PMID: 30981977 (KEYNOTE-042)",
423
+ type: "Phase III Multi-Center Trial",
424
+ title: "Pembrolizumab versus platinum-based chemotherapy in patients with locally advanced/metastatic NSCLC",
425
+ snippet: "Extended overall survival benefit was confirmed in all PD-L1 positive strata (TPS ≥ 1%), with the most profound clinical separation observed in the TPS ≥ 50% cohort (median OS 20.0 vs 12.2 months; HR 0.69; P=0.0003).",
426
+ metrics: ["HR: 0.69", "OS: 20.0 vs 12.2 mo", "N = 1,274"]
427
+ },
428
+ {
429
+ pmid: "NCT02142738",
430
+ type: "5-Year Registry Follow-up",
431
+ title: "Five-Year Overall Survival in Advanced NSCLC Treated with First-Line Pembrolizumab",
432
+ snippet: "5-year OS rate was 31.9% in the pembrolizumab cohort compared to 16.3% in the chemotherapy control arm, establishing long-term durable immune control without cumulative toxicity.",
433
+ metrics: ["5-Year OS: 31.9%", "Tox Grade ≥3: 31.2%"]
434
+ }
435
+ ],
436
+ cart: [
437
+ {
438
+ pmid: "PMID: 29281775 (ELIANA)",
439
+ type: "Phase II Multi-Center Global Trial",
440
+ title: "Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia",
441
+ snippet: "Overall remission rate within 3 months was 81%. Cytokine release syndrome (CRS) occurred in 77% of patients; successfully mitigated using the IL-6 receptor antagonist tocilizumab without impairing CAR-T persistence.",
442
+ metrics: ["Remission: 81%", "CRS Rate: 77%", "N = 75"]
443
+ },
444
+ {
445
+ pmid: "PMID: 30500732",
446
+ type: "Consensus Clinical Guidelines (ASTCT)",
447
+ title: "ASTCT Consensus Grading for Cytokine Release Syndrome and Neurologic Toxicity Associated with Immune Effector Cells",
448
+ snippet: "Established unified clinical staging for CRS: Grade 1 (Fever ≥38.0°C), Grade 2 (Hypotension responding to fluids), Grade 3 (Vasopressors required), Grade 4 (Life-threatening hypoxia/mechanical ventilation).",
449
+ metrics: ["ASTCT Criteria", "Tocilizumab First-line"]
450
+ }
451
+ ],
452
+ mrna: [
453
+ {
454
+ pmid: "PMID: 38242131 (KEYNOTE-942)",
455
+ type: "Phase IIb Randomized Trial",
456
+ title: "Individualized Neoantigen Therapy mRNA-4157 (V940) plus Pembrolizumab in Resected High-Risk Melanoma",
457
+ snippet: "Adjuvant mRNA-4157 combined with pembrolizumab prolonged recurrence-free survival compared with pembrolizumab monotherapy (HR 0.56; 95% CI 0.31-0.99; two-sided P=0.046), reducing risk of recurrence or death by 44%.",
458
+ metrics: ["Recurrence Risk: -44%", "HR: 0.56", "N = 157"]
459
+ }
460
+ ],
461
+ kras: [
462
+ {
463
+ pmid: "PMID: 32955178 (CodeBreaK 100)",
464
+ type: "Phase I/II Clinical Trial",
465
+ title: "K-Ras G12C Inhibition with Sotorasib in Advanced Solid Tumors",
466
+ snippet: "In patients with pretreated KRAS p.G12C mutant colorectal cancer, sotorasib showed confirmed response in 7.1% and disease control in 73.8% (median PFS 4.0 months). Single-agent resistance circumvented via EGFR co-blockade.",
467
+ metrics: ["DCR: 73.8%", "PFS: 4.0 mo", "N = 42"]
468
+ }
469
+ ]
470
+ };
471
+
472
+ function renderResults() {
473
+ const query = queryInput.value.toLowerCase();
474
+ const topK = parseInt(topkSlider.value);
475
+
476
+ // Guardrail logic
477
+ if (query.includes('antibiotic') || query.includes('what should i take') || query.includes('chest pain') || query.includes('buy') || query.includes('my doctor')) {
478
+ guardrailAlert.style.display = 'block';
479
+ evidenceList.innerHTML = '<div style="padding: 24px; text-align: center; color: var(--danger); font-size: 13px;">⛔ Request terminated by clinical safety guardrails. Academic literature queries only.</div>';
480
+ evidenceCount.textContent = '0 Evidence Units';
481
+ return;
482
+ } else {
483
+ guardrailAlert.style.display = 'none';
484
+ }
485
+
486
+ let key = 'pembro';
487
+ if (query.includes('car-t') || query.includes('cytokine') || query.includes('crs')) key = 'cart';
488
+ else if (query.includes('mrna') || query.includes('vaccine') || query.includes('melanoma')) key = 'mrna';
489
+ else if (query.includes('kras') || query.includes('sotorasib') || query.includes('colorectal')) key = 'kras';
490
+
491
+ const items = corpus[key] || corpus.pembro;
492
+ const selected = items.slice(0, topK);
493
+
494
+ evidenceCount.textContent = `${selected.length} Evidence Units`;
495
+ evidenceList.innerHTML = '';
496
+
497
+ selected.forEach(doc => {
498
+ const el = document.createElement('div');
499
+ el.className = 'evidence-card';
500
+ el.innerHTML = `
501
+ <div class="evidence-head">
502
+ <span class="pmid-badge">${doc.pmid}</span>
503
+ <span class="study-type">${doc.type}</span>
504
+ </div>
505
+ <div class="evidence-title">${doc.title}</div>
506
+ <div class="evidence-snippet">"${doc.snippet}"</div>
507
+ <div>
508
+ ${doc.metrics.map(m => `<span class="metric-pill">${m}</span>`).join('')}
509
+ </div>
510
+ `;
511
+ evidenceList.appendChild(el);
512
+ });
513
+ }
514
+
515
+ queryPreset.addEventListener('change', () => {
516
+ const val = queryPreset.value;
517
+ if (val === 'personal_blocked') {
518
+ queryInput.value = "I have sharp chest pains, which antibiotic should I buy?";
519
+ } else {
520
+ queryInput.value = queryPreset.options[queryPreset.selectedIndex].text;
521
+ }
522
+ renderResults();
523
+ });
524
+
525
+ alphaSlider.addEventListener('input', () => {
526
+ const a = parseFloat(alphaSlider.value);
527
+ alphaVal.textContent = `${a.toFixed(2)} / ${(1-a).toFixed(2)}`;
528
+ });
529
+
530
+ topkSlider.addEventListener('input', () => {
531
+ topkVal.textContent = `${topkSlider.value} Chunks`;
532
+ renderResults();
533
+ });
534
+
535
+ btnSearch.addEventListener('click', renderResults);
536
+
537
+ // Initial render
538
+ renderResults();
539
+ </script>
540
+ </body>
541
  </html>