[ { "title": "SPHERE-I-SCIENCE", "sphere": "science", "track": "Root sphere repo", "entryType": "repository", "status": "active", "summary": "Computational science research across oncology, plant science, metabolomics, neuroscience, ecology, and life systems.", "tags": [ "science", "root sphere repo", "s", "repository", "sphere-i-science", "computational", "oncology" ], "links": [ { "label": "Repo", "href": "https://github.com/K-RnD-Lab/SPHERE-I-SCIENCE" }, { "label": "README", "href": "https://github.com/K-RnD-Lab/SPHERE-I-SCIENCE/blob/main/README.md" } ], "primarySphere": "science", "secondarySpheres": [], "combo": "S", "artifactType": "repository", "deliveryLayers": [ "GitHub" ], "validationStage": "taxonomy" }, { "title": "S1 Biomedical And Oncology", "sphere": "science", "track": "S1", "entryType": "lane", "status": "active", "summary": "S1 is the biomedical and translational oncology block inside SPHERE-I-SCIENCE.", "tags": [ "science", "s1", "s", "lane", "biomedical", "oncology", "translational" ], "links": [ { "label": "README", "href": "https://github.com/K-RnD-Lab/SPHERE-I-SCIENCE/blob/main/S1%20%E2%80%94%20%F0%9F%A9%BA%20%20Biomedical%20%26%20Oncology/README.md" }, { "label": "Folder", "href": "https://github.com/K-RnD-Lab/SPHERE-I-SCIENCE/tree/main/S1%20%E2%80%94%20%F0%9F%A9%BA%20%20Biomedical%20%26%20Oncology" } ], "primarySphere": "science", "secondarySpheres": [], "combo": "S", "artifactType": "lane", "deliveryLayers": [ "GitHub" ], "validationStage": "taxonomy" }, { "title": "OpenVariant: An Open-Source Variant Pathogenicity Classifier Benchmarked Against AlphaMissense", "sphere": "science", "track": "S1-A-R1", "entryType": "study", "status": "active", "summary": "Model performance: AUC-ROC = 0.942 (XGBoost, target 0.939) | AUC-ROC = 0.935 (AlphaMissense placeholder, target 0.934) | Dataset: N = 1,804 (⚠ SIMULATED)", "tags": [ "science", "s1-a-r1", "s+t", "research-tool", "openvariant", "open-source", "variant" ], "links": [ { "label": "README", "href": "https://github.com/K-RnD-Lab/SPHERE-I-SCIENCE/blob/main/S1%20%E2%80%94%20%F0%9F%A9%BA%20%20Biomedical%20%26%20Oncology/S1-A%20%C2%B7%20%F0%9F%A7%AC%20PHYLO-GENOMICS/S1-A-R1%20%C2%B7%20Variant%20classification/R1a-openvariant/README.md" }, { "label": "Folder", "href": "https://github.com/K-RnD-Lab/SPHERE-I-SCIENCE/tree/main/S1%20%E2%80%94%20%F0%9F%A9%BA%20%20Biomedical%20%26%20Oncology/S1-A%20%C2%B7%20%F0%9F%A7%AC%20PHYLO-GENOMICS/S1-A-R1%20%C2%B7%20Variant%20classification/R1a-openvariant" } ], "primarySphere": "science", "secondarySpheres": [ "technology" ], "combo": "S+T", "artifactType": "research_tool", "deliveryLayers": [ "GitHub" ], "validationStage": "prototype" }, { "title": "Identification of Tumor Suppressor miRNAs Silenced in BRCA2-Mutant Breast Cancer: A Multi-Dataset Meta-Analysis", "sphere": "science", "track": "S1-B-R1", "entryType": "study", "status": "active", "summary": "Model performance: 25 significant DE miRNAs identified (padj ≤ 0.05, |log2FC| ≥ 0.3) | Dataset: N = 300 (13 BRCA2-mutant, 287 wildtype) — ⚠️ SIMULATED DATA", "tags": [ "science", "s1-b-r1", "s", "hypothesis", "identification", "tumor", "suppressor" ], "links": [ { "label": "README", "href": "https://github.com/K-RnD-Lab/SPHERE-I-SCIENCE/blob/main/S1%20%E2%80%94%20%F0%9F%A9%BA%20%20Biomedical%20%26%20Oncology/S1-B%20%C2%B7%20%F0%9F%94%AC%20PHYLO-RNA/S1-B-R1%20%C2%B7%20miRNA%20silencing/R1a-brca2-mirna/README.md" }, { "label": "Folder", "href": "https://github.com/K-RnD-Lab/SPHERE-I-SCIENCE/tree/main/S1%20%E2%80%94%20%F0%9F%A9%BA%20%20Biomedical%20%26%20Oncology/S1-B%20%C2%B7%20%F0%9F%94%AC%20PHYLO-RNA/S1-B-R1%20%C2%B7%20miRNA%20silencing/R1a-brca2-mirna" } ], "primarySphere": "science", "secondarySpheres": [], "combo": "S", "artifactType": "hypothesis", "deliveryLayers": [ "GitHub" ], "validationStage": "exploratory" }, { "title": "Computational Identification of siRNA Synthetic Lethal Targets in TP53-Mutant Lung Adenocarcinoma", "sphere": "science", "track": "S1-B-R2", "entryType": "study", "status": "active", "summary": "Pipeline validation: PLK1 and CDK1 recovered as positive clinical controls | Dataset: N = 566 (295 TP53-mut + 271 WT) [SIMULATED]", "tags": [ "science", "s1-b-r2", "s+e+t", "research-tool", "computational", "identification", "sirna" ], "links": [ { "label": "README", "href": "https://github.com/K-RnD-Lab/SPHERE-I-SCIENCE/blob/main/S1%20%E2%80%94%20%F0%9F%A9%BA%20%20Biomedical%20%26%20Oncology/S1-B%20%C2%B7%20%F0%9F%94%AC%20PHYLO-RNA/S1-B-R2%20%C2%B7%20siRNA%20SL/R2a-tp53-sirna/README.md" }, { "label": "Folder", "href": "https://github.com/K-RnD-Lab/SPHERE-I-SCIENCE/tree/main/S1%20%E2%80%94%20%F0%9F%A9%BA%20%20Biomedical%20%26%20Oncology/S1-B%20%C2%B7%20%F0%9F%94%AC%20PHYLO-RNA/S1-B-R2%20%C2%B7%20siRNA%20SL/R2a-tp53-sirna" } ], "primarySphere": "science", "secondarySpheres": [ "entrepreneurship", "technology" ], "combo": "S+E+T", "artifactType": "research_tool", "deliveryLayers": [ "GitHub" ], "validationStage": "prototype" }, { "title": "lncRNA Regulatory Networks Controlling TREM2-Dependent Microglial Inflammation: Implications for Alzheimer's Therapy", "sphere": "science", "track": "S1-B-R3", "entryType": "study", "status": "active", "summary": "Data type: Simulated iPSC-derived microglia RNA-seq (TREM2-KO vs WT) | Dataset: 2 independent simulated datasets × 12 samples each (not biological replicates of one another)", "tags": [ "science", "s1-b-r3", "s", "hypothesis", "lncrna", "regulatory", "networks" ], "links": [ { "label": "README", "href": "https://github.com/K-RnD-Lab/SPHERE-I-SCIENCE/blob/main/S1%20%E2%80%94%20%F0%9F%A9%BA%20%20Biomedical%20%26%20Oncology/S1-B%20%C2%B7%20%F0%9F%94%AC%20PHYLO-RNA/S1-B-R3%20%C2%B7%20lncRNA%20%2B%20ASO/R3a-lncrna-trem2/README.md" }, { "label": "Folder", "href": "https://github.com/K-RnD-Lab/SPHERE-I-SCIENCE/tree/main/S1%20%E2%80%94%20%F0%9F%A9%BA%20%20Biomedical%20%26%20Oncology/S1-B%20%C2%B7%20%F0%9F%94%AC%20PHYLO-RNA/S1-B-R3%20%C2%B7%20lncRNA%20%2B%20ASO/R3a-lncrna-trem2" } ], "primarySphere": "science", "secondarySpheres": [], "combo": "S", "artifactType": "hypothesis", "deliveryLayers": [ "GitHub" ], "validationStage": "exploratory" }, { "title": "Computational Discovery of Small Molecules Targeting FGFR3 mRNA for Bladder Cancer", "sphere": "science", "track": "S1-C-R1", "entryType": "study", "status": "active", "summary": "Model performance: Top-2 RNA-binding score = 0.793 / 0.789 (SIMULATED) | Dataset: N = 200 compounds (SIMULATED virtual screen)", "tags": [ "science", "s1-c-r1", "s+t", "research-tool", "computational", "discovery", "small" ], "links": [ { "label": "README", "href": "https://github.com/K-RnD-Lab/SPHERE-I-SCIENCE/blob/main/S1%20%E2%80%94%20%F0%9F%A9%BA%20%20Biomedical%20%26%20Oncology/S1-C%20%C2%B7%20%F0%9F%92%8A%20PHYLO-DRUG/S1-C-R1%20%C2%B7%20RNA-directed%20drug/R1a-fgfr3-rna-drug/README.md" }, { "label": "Folder", "href": "https://github.com/K-RnD-Lab/SPHERE-I-SCIENCE/tree/main/S1%20%E2%80%94%20%F0%9F%A9%BA%20%20Biomedical%20%26%20Oncology/S1-C%20%C2%B7%20%F0%9F%92%8A%20PHYLO-DRUG/S1-C-R1%20%C2%B7%20RNA-directed%20drug/R1a-fgfr3-rna-drug" } ], "primarySphere": "science", "secondarySpheres": [ "technology" ], "combo": "S+T", "artifactType": "research_tool", "deliveryLayers": [ "GitHub" ], "validationStage": "prototype" }, { "title": "Machine Learning Prediction of Protein Corona Composition in Lipid Nanoparticles from Physicochemical Properties", "sphere": "science", "track": "S1-D-R1", "entryType": "study", "status": "active", "summary": "Model performance: Macro-OvR AUC = 0.791 (reported) / 0.836 [SIMULATED-CIRCULAR] | Dataset: N = 19,200 (LNPDB, simulated for this demo)", "tags": [ "science", "s1-d-r1", "s+t", "research-tool", "machine", "learning", "prediction" ], "links": [ { "label": "README", "href": "https://github.com/K-RnD-Lab/SPHERE-I-SCIENCE/blob/main/S1%20%E2%80%94%20%F0%9F%A9%BA%20%20Biomedical%20%26%20Oncology/S1-D%20%C2%B7%20%F0%9F%A7%AA%20PHYLO-LNP/S1-D-R1%20%C2%B7%20Serum%20corona/R1a-lnp-corona-ml/README.md" }, { "label": "Folder", "href": "https://github.com/K-RnD-Lab/SPHERE-I-SCIENCE/tree/main/S1%20%E2%80%94%20%F0%9F%A9%BA%20%20Biomedical%20%26%20Oncology/S1-D%20%C2%B7%20%F0%9F%A7%AA%20PHYLO-LNP/S1-D-R1%20%C2%B7%20Serum%20corona/R1a-lnp-corona-ml" } ], "primarySphere": "science", "secondarySpheres": [ "technology" ], "combo": "S+T", "artifactType": "research_tool", "deliveryLayers": [ "GitHub" ], "validationStage": "prototype" }, { "title": "Machine Learning Prediction of Protein Corona Composition in Lipid Nanoparticles from Physicochemical Properties", "sphere": "science", "track": "S1-D-R2", "entryType": "study", "status": "active", "summary": "Model performance: XGBoost AUC = 0.877 (5-fold CV, simulated; target spec: 0.791) | Corona PoC AUC = 0.834 (LOOCV) | Dataset: N = 19,200 (SIMULATED)", "tags": [ "science", "s1-d-r2", "s", "hypothesis", "machine", "learning", "prediction" ], "links": [ { "label": "README", "href": "https://github.com/K-RnD-Lab/SPHERE-I-SCIENCE/blob/main/S1%20%E2%80%94%20%F0%9F%A9%BA%20%20Biomedical%20%26%20Oncology/S1-D%20%C2%B7%20%F0%9F%A7%AA%20PHYLO-LNP/S1-D-R2%20%C2%B7%20Flow%20corona/R2a-flow-corona/study1/README.md" }, { "label": "Folder", "href": "https://github.com/K-RnD-Lab/SPHERE-I-SCIENCE/tree/main/S1%20%E2%80%94%20%F0%9F%A9%BA%20%20Biomedical%20%26%20Oncology/S1-D%20%C2%B7%20%F0%9F%A7%AA%20PHYLO-LNP/S1-D-R2%20%C2%B7%20Flow%20corona/R2a-flow-corona/study1" } ], "primarySphere": "science", "secondarySpheres": [], "combo": "S", "artifactType": "hypothesis", "deliveryLayers": [ "GitHub" ], "validationStage": "exploratory" }, { "title": "Predicting Protein Corona Remodeling in Lipid Nanoparticles Under Physiological Flow: Closing the Static-Dynamic Gap", "sphere": "science", "track": "S1-D-R2", "entryType": "study", "status": "active", "summary": "Model performance: RF Train R² = 0.781 | LOOCV R² = −0.281 (underpowered, N=32) | Dataset: N = 32 matched pairs (SIMULATED)", "tags": [ "science", "s1-d-r2", "s+t", "research-tool", "predicting", "protein", "corona" ], "links": [ { "label": "README", "href": "https://github.com/K-RnD-Lab/SPHERE-I-SCIENCE/blob/main/S1%20%E2%80%94%20%F0%9F%A9%BA%20%20Biomedical%20%26%20Oncology/S1-D%20%C2%B7%20%F0%9F%A7%AA%20PHYLO-LNP/S1-D-R2%20%C2%B7%20Flow%20corona/R2a-flow-corona/study2/README.md" }, { "label": "Folder", "href": "https://github.com/K-RnD-Lab/SPHERE-I-SCIENCE/tree/main/S1%20%E2%80%94%20%F0%9F%A9%BA%20%20Biomedical%20%26%20Oncology/S1-D%20%C2%B7%20%F0%9F%A7%AA%20PHYLO-LNP/S1-D-R2%20%C2%B7%20Flow%20corona/R2a-flow-corona/study2" } ], "primarySphere": "science", "secondarySpheres": [ "technology" ], "combo": "S+T", "artifactType": "research_tool", "deliveryLayers": [ "GitHub" ], "validationStage": "prototype" }, { "title": "Ionizable Lipid Properties Predicting ApoE Enrichment in LNP Protein Corona for Blood-Brain Barrier Crossing in Glioblastoma", "sphere": "science", "track": "S1-D-R3", "entryType": "study", "status": "active", "summary": "Model performance: LOO-CV R² = 0.542 (overall; dominated by lipid-type confound — within-group ionizable R²=−1.571), Pearson r = 0.780, MAE = 4.9% | Dataset: N = 22 (SIMULATED — literature-grounded ranges)", "tags": [ "science", "s1-d-r3", "s+t", "research-tool", "ionizable", "lipid", "properties" ], "links": [ { "label": "README", "href": "https://github.com/K-RnD-Lab/SPHERE-I-SCIENCE/blob/main/S1%20%E2%80%94%20%F0%9F%A9%BA%20%20Biomedical%20%26%20Oncology/S1-D%20%C2%B7%20%F0%9F%A7%AA%20PHYLO-LNP/S1-D-R3%20%C2%B7%20Brain%20BBB/R3a-lnp-bbb/README.md" }, { "label": "Folder", "href": 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"label": "README", "href": "https://github.com/K-RnD-Lab/SPHERE-I-SCIENCE/blob/main/S1%20%E2%80%94%20%F0%9F%A9%BA%20%20Biomedical%20%26%20Oncology/S1-D%20%C2%B7%20%F0%9F%A7%AA%20PHYLO-LNP/S1-D-R4%20%C2%B7%20NLP/R4a-autocorona-nlp/README.md" }, { "label": "Folder", "href": "https://github.com/K-RnD-Lab/SPHERE-I-SCIENCE/tree/main/S1%20%E2%80%94%20%F0%9F%A9%BA%20%20Biomedical%20%26%20Oncology/S1-D%20%C2%B7%20%F0%9F%A7%AA%20PHYLO-LNP/S1-D-R4%20%C2%B7%20NLP/R4a-autocorona-nlp" } ], "primarySphere": "science", "secondarySpheres": [ "technology" ], "combo": "S+T", "artifactType": "research_tool", "deliveryLayers": [ "GitHub" ], "validationStage": "prototype" }, { "title": "Machine Learning Prediction of Protein Corona Composition in Lipid Nanoparticles from Physicochemical Properties", "sphere": "science", "track": "S1-D-R4", "entryType": "study", "status": "scaffold", "summary": "Model performance: XGBoost AUC = 0.791 (5-fold CV) | Dataset: N = 19,200 transfection records", "tags": [ "science", "s1-d-r4", "s", "hypothesis", "machine", "learning", "prediction" ], "links": [ { "label": "README", "href": "https://github.com/K-RnD-Lab/SPHERE-I-SCIENCE/blob/main/S1%20%E2%80%94%20%F0%9F%A9%BA%20%20Biomedical%20%26%20Oncology/S1-D%20%C2%B7%20%F0%9F%A7%AA%20PHYLO-LNP/S1-D-R4%20%C2%B7%20NLP/R4a-autocorona-nlp/project1_lnp_ml/README.md" }, { "label": "Folder", "href": "https://github.com/K-RnD-Lab/SPHERE-I-SCIENCE/tree/main/S1%20%E2%80%94%20%F0%9F%A9%BA%20%20Biomedical%20%26%20Oncology/S1-D%20%C2%B7%20%F0%9F%A7%AA%20PHYLO-LNP/S1-D-R4%20%C2%B7%20NLP/R4a-autocorona-nlp/project1_lnp_ml" } ], "primarySphere": "science", "secondarySpheres": [], "combo": "S", "artifactType": "hypothesis", "deliveryLayers": [ "GitHub" ], "validationStage": "scaffold" }, { "title": "Machine Learning Prediction of LNP Transfection Efficacy from Physicochemical and Formulation Features", "sphere": "science", "track": "S1-E-R1", "entryType": "study", "status": "active", "summary": "Model performance: XGBoost AUC = 0.782 (5-fold CV) | Dataset: N = 19,200 (SIMULATED — based on LNPDB statistics)", "tags": [ "science", "s1-e-r1", "s+e", "hypothesis", "machine", "learning", "prediction" ], "links": [ { "label": "README", "href": "https://github.com/K-RnD-Lab/SPHERE-I-SCIENCE/blob/main/S1%20%E2%80%94%20%F0%9F%A9%BA%20%20Biomedical%20%26%20Oncology/S1-E%20%C2%B7%20%F0%9F%A9%B8%20PHYLO-BIOMARKERS/S1-E-R1%20%C2%B7%20Liquid%20biopsy/R1a-liquid-biopsy/project1_lnp_transfection/README.md" }, { "label": "Folder", "href": "https://github.com/K-RnD-Lab/SPHERE-I-SCIENCE/tree/main/S1%20%E2%80%94%20%F0%9F%A9%BA%20%20Biomedical%20%26%20Oncology/S1-E%20%C2%B7%20%F0%9F%A9%B8%20PHYLO-BIOMARKERS/S1-E-R1%20%C2%B7%20Liquid%20biopsy/R1a-liquid-biopsy/project1_lnp_transfection" } ], "primarySphere": "science", "secondarySpheres": [ "entrepreneurship" ], "combo": "S+E", "artifactType": "hypothesis", "deliveryLayers": [ "GitHub" ], "validationStage": "exploratory" }, { "title": "Protein Corona Fingerprinting of Lipid Nanoparticles as a Liquid Biopsy Biomarker: Distinguishing Cancer Patients from Healthy Individuals Using Machine Learning", "sphere": "science", "track": "S1-E-R1", "entryType": "study", "status": "active", "summary": "Model performance: RF GroupKFold AUC = 0.993 ± 0.005 (tissue-level only) | Dataset: N = 576 samples × 8,843 proteins (SIMULATED — based on CPTAC statistics)", "tags": [ "science", "s1-e-r1", "s+e", "hypothesis", "protein", "corona", "fingerprinting" ], "links": [ { "label": "README", "href": "https://github.com/K-RnD-Lab/SPHERE-I-SCIENCE/blob/main/S1%20%E2%80%94%20%F0%9F%A9%BA%20%20Biomedical%20%26%20Oncology/S1-E%20%C2%B7%20%F0%9F%A9%B8%20PHYLO-BIOMARKERS/S1-E-R1%20%C2%B7%20Liquid%20biopsy/R1a-liquid-biopsy/project2_corona_biopsy/README.md" }, { "label": "Folder", "href": 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"secondarySpheres": [ "technology" ], "combo": "S+T", "artifactType": "lane", "deliveryLayers": [ "GitHub" ], "validationStage": "taxonomy" }, { "title": "S4 Biochemistry & Metabolomics", "sphere": "science", "track": "S4", "entryType": "lane", "status": "active", "summary": "S4 is the cross-organism chemistry and mechanism lane inside SPHERE-I-SCIENCE.", "tags": [ "science", "s4", "s", "lane", "biochemistry", "metabolomics", "cross-organism" ], "links": [ { "label": "README", "href": "https://github.com/K-RnD-Lab/SPHERE-I-SCIENCE/blob/main/S4%20%E2%80%94%20%E2%9A%97%EF%B8%8F%20Biochemistry%20%26%20Metabolomics/README.md" }, { "label": "Folder", "href": "https://github.com/K-RnD-Lab/SPHERE-I-SCIENCE/tree/main/S4%20%E2%80%94%20%E2%9A%97%EF%B8%8F%20Biochemistry%20%26%20Metabolomics" } ], "primarySphere": "science", "secondarySpheres": [], "combo": "S", "artifactType": "lane", "deliveryLayers": [ "GitHub" ], "validationStage": "taxonomy" }, { "title": "S5 Neuroscience & Aging", "sphere": "science", "track": "S5", "entryType": "lane", "status": "active", "summary": "S5 covers brain, cognition, neuroinflammation, and computational aging questions.", "tags": [ "science", "s5", "s+t", "lane", "neuroscience", "aging", "covers" ], "links": [ { "label": "README", "href": "https://github.com/K-RnD-Lab/SPHERE-I-SCIENCE/blob/main/S5%20%E2%80%94%20%F0%9F%A7%A0%20Neuroscience%20%26%20Aging/README.md" }, { "label": "Folder", "href": "https://github.com/K-RnD-Lab/SPHERE-I-SCIENCE/tree/main/S5%20%E2%80%94%20%F0%9F%A7%A0%20Neuroscience%20%26%20Aging" } ], "primarySphere": "science", "secondarySpheres": [ "technology" ], "combo": "S+T", "artifactType": "lane", "deliveryLayers": [ "GitHub" ], "validationStage": "taxonomy" }, { "title": "S6 Ecology & Environmental Science", "sphere": "science", "track": "S6", "entryType": "lane", "status": "active", "summary": "S6 covers environmental systems rather than organism-intrinsic molecular biology.", "tags": [ "science", "s6", "s", "lane", "ecology", "environmental", "covers" ], "links": [ { "label": "README", "href": "https://github.com/K-RnD-Lab/SPHERE-I-SCIENCE/blob/main/S6%20%E2%80%94%20%F0%9F%8C%8D%20Ecology%20%26%20Environmental%20Science/README.md" }, { "label": "Folder", "href": "https://github.com/K-RnD-Lab/SPHERE-I-SCIENCE/tree/main/S6%20%E2%80%94%20%F0%9F%8C%8D%20Ecology%20%26%20Environmental%20Science" } ], "primarySphere": "science", "secondarySpheres": [], "combo": "S", "artifactType": "lane", "deliveryLayers": [ "GitHub" ], "validationStage": "taxonomy" }, { "title": "📚 S7 - K Life OS", "sphere": "science", "track": "S7", "entryType": "lane", "status": "active", "summary": "Science-facing lane for measurable life systems, cognition, adaptive training, self-tracking, and longitudinal human-pattern research.", "tags": [ "science", "s7", "s+t", "lane", "life", "science-facing", "measurable" ], "links": [ { "label": "README", "href": 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"secondarySpheres": [], "combo": "S", "artifactType": "hypothesis", "deliveryLayers": [ "GitHub" ], "validationStage": "exploratory" }, { "title": "S7-E · 🤝 Parenting or Family", "sphere": "science", "track": "S7-E", "entryType": "study", "status": "active", "summary": "A sub-lane inside 📚 S7 — K Life OS.", "tags": [ "science", "s7-e", "s", "hypothesis", "parenting", "family", "sub-lane" ], "links": [ { "label": "README", "href": "https://github.com/K-RnD-Lab/SPHERE-I-SCIENCE/blob/main/S7%20%E2%80%94%20%F0%9F%93%9A%20K%20Life%20OS/S7-E%20%C2%B7%20%F0%9F%A4%9D%20Parenting%20or%20Family/README.md" }, { "label": "Folder", "href": "https://github.com/K-RnD-Lab/SPHERE-I-SCIENCE/tree/main/S7%20%E2%80%94%20%F0%9F%93%9A%20K%20Life%20OS/S7-E%20%C2%B7%20%F0%9F%A4%9D%20Parenting%20or%20Family" } ], "primarySphere": "science", "secondarySpheres": [], "combo": "S", "artifactType": "hypothesis", "deliveryLayers": [ "GitHub" ], "validationStage": "exploratory" }, { "title": "S7-F · 📚 Recreation and Hobbies", "sphere": "science", "track": "S7-F", "entryType": "study", "status": "active", "summary": "A sub-lane inside 📚 S7 — K Life OS.", "tags": [ "science", "s7-f", "s", "hypothesis", "recreation", "hobbies", "sub-lane" ], "links": [ { "label": "README", "href": "https://github.com/K-RnD-Lab/SPHERE-I-SCIENCE/blob/main/S7%20%E2%80%94%20%F0%9F%93%9A%20K%20Life%20OS/S7-F%20%C2%B7%20%F0%9F%93%9A%20Recreation%20and%20Hobbies/README.md" }, { "label": "Folder", "href": "https://github.com/K-RnD-Lab/SPHERE-I-SCIENCE/tree/main/S7%20%E2%80%94%20%F0%9F%93%9A%20K%20Life%20OS/S7-F%20%C2%B7%20%F0%9F%93%9A%20Recreation%20and%20Hobbies" } ], "primarySphere": "science", "secondarySpheres": [], "combo": "S", "artifactType": "hypothesis", "deliveryLayers": [ "GitHub" ], "validationStage": "exploratory" }, { "title": "S7-G · 👤 Community Involvement", "sphere": "science", "track": "S7-G", "entryType": "study", "status": "active", "summary": "A sub-lane inside 📚 S7 — K Life OS.", "tags": [ "science", "s7-g", "s", "hypothesis", "community", "involvement", "sub-lane" ], "links": [ { "label": "README", "href": "https://github.com/K-RnD-Lab/SPHERE-I-SCIENCE/blob/main/S7%20%E2%80%94%20%F0%9F%93%9A%20K%20Life%20OS/S7-G%20%C2%B7%20%F0%9F%91%A4%20Community%20Involvement/README.md" }, { "label": "Folder", "href": "https://github.com/K-RnD-Lab/SPHERE-I-SCIENCE/tree/main/S7%20%E2%80%94%20%F0%9F%93%9A%20K%20Life%20OS/S7-G%20%C2%B7%20%F0%9F%91%A4%20Community%20Involvement" } ], "primarySphere": "science", "secondarySpheres": [], "combo": "S", "artifactType": "hypothesis", "deliveryLayers": [ "GitHub" ], "validationStage": "exploratory" }, { "title": "S7-H · 🌳 Physical Health", "sphere": "science", "track": "S7-H", "entryType": "study", "status": "active", "summary": "A sub-lane inside 📚 S7 — K Life OS.", "tags": [ "science", "s7-h", "s", "hypothesis", "physical", "health", "sub-lane" ], "links": [ { "label": "README", "href": 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"Folder", "href": "https://github.com/K-RnD-Lab/SPHERE-I-SCIENCE/tree/main/S7%20%E2%80%94%20%F0%9F%93%9A%20K%20Life%20OS/S7-L%20%C2%B7%20%F0%9F%A7%98%20Spirituality" } ], "primarySphere": "science", "secondarySpheres": [], "combo": "S", "artifactType": "hypothesis", "deliveryLayers": [ "GitHub" ], "validationStage": "exploratory" }, { "title": "S7-M · 🧭 Longitudinal Reviews & Life Wheel Synthesis", "sphere": "science", "track": "S7-M", "entryType": "study", "status": "active", "summary": "A meta-lane inside 📚 S7 - K Life OS.", "tags": [ "science", "s7-m", "s", "hypothesis", "longitudinal", "reviews", "life" ], "links": [ { "label": "README", "href": "https://github.com/K-RnD-Lab/SPHERE-I-SCIENCE/blob/main/S7%20%E2%80%94%20%F0%9F%93%9A%20K%20Life%20OS/S7-M%20%C2%B7%20%F0%9F%A7%AD%20Longitudinal%20Reviews%20%26%20Life%20Wheel%20Synthesis/README.md" }, { "label": "Folder", "href": "https://github.com/K-RnD-Lab/SPHERE-I-SCIENCE/tree/main/S7%20%E2%80%94%20%F0%9F%93%9A%20K%20Life%20OS/S7-M%20%C2%B7%20%F0%9F%A7%AD%20Longitudinal%20Reviews%20%26%20Life%20Wheel%20Synthesis" } ], "primarySphere": "science", "secondarySpheres": [], "combo": "S", "artifactType": "hypothesis", "deliveryLayers": [ "GitHub" ], "validationStage": "exploratory" }, { "title": "SPHERE-II-ENTREPRENEURSHIP", "sphere": "entrepreneurship", "track": "Root sphere repo", "entryType": "repository", "status": "active", "summary": "Applied research for venture design, market intelligence, ecosystem mapping, and public cases.", "tags": [ "entrepreneurship", "root sphere repo", "e", "repository", "sphere-ii-entrepreneurship", "applied", "venture" ], "links": [ { "label": "Repo", "href": "https://github.com/K-RnD-Lab/SPHERE-II-ENTREPRENEURSHIP" }, { "label": "README", "href": "https://github.com/K-RnD-Lab/SPHERE-II-ENTREPRENEURSHIP/blob/main/README.md" } ], "primarySphere": "entrepreneurship", "secondarySpheres": [], "combo": "E", "artifactType": "repository", "deliveryLayers": [ "GitHub" ], "validationStage": "taxonomy" }, { "title": "R1a Lab-to-Market Opportunity Map", "sphere": "entrepreneurship", "track": "E1-R1", "entryType": "study", "status": "scaffold", "summary": "Which translational opportunity spaces are the most plausible first commercial or collaboration paths for outputs generated inside K R&D Lab?", "tags": [ "entrepreneurship", "e1-r1", "s+e", "venture-case", "r1a", "lab-to-market", "opportunity" ], "links": [ { "label": "README", "href": "https://github.com/K-RnD-Lab/SPHERE-II-ENTREPRENEURSHIP/blob/main/E1%20-%20Venture%2C%20Product%20%26%20Opportunity%20Systems/E1-R1%20-%20Opportunity%20Mapping%20%26%20Problem%20Framing/R1a-lab-to-market-opportunity-map/README.md" }, { "label": "Folder", "href": "https://github.com/K-RnD-Lab/SPHERE-II-ENTREPRENEURSHIP/tree/main/E1%20-%20Venture%2C%20Product%20%26%20Opportunity%20Systems/E1-R1%20-%20Opportunity%20Mapping%20%26%20Problem%20Framing/R1a-lab-to-market-opportunity-map" } ], "primarySphere": "entrepreneurship", "secondarySpheres": [ "science" ], "combo": "S+E", "artifactType": "venture_case", "deliveryLayers": [ "GitHub" ], "validationStage": "exploratory" }, { "title": "R1a Translational Audience Segments", "sphere": "entrepreneurship", "track": "E2-R1", "entryType": "study", "status": "scaffold", "summary": "Which audience groups are most distinct and strategically relevant for K R&D Lab outputs across science, tooling, and public-facing research artifacts?", "tags": [ "entrepreneurship", "e2-r1", "s+e+t", "venture-case", "r1a", "translational", "audience" ], "links": [ { "label": "README", "href": "https://github.com/K-RnD-Lab/SPHERE-II-ENTREPRENEURSHIP/blob/main/E2%20-%20Market%2C%20Audience%20%26%20Behavioral%20Intelligence/E2-R1%20-%20Audience%20Segmentation/R1a-translational-audience-segments/README.md" }, { "label": "Folder", "href": "https://github.com/K-RnD-Lab/SPHERE-II-ENTREPRENEURSHIP/tree/main/E2%20-%20Market%2C%20Audience%20%26%20Behavioral%20Intelligence/E2-R1%20-%20Audience%20Segmentation/R1a-translational-audience-segments" } ], "primarySphere": "entrepreneurship", "secondarySpheres": [ "science", "technology" ], "combo": "S+E+T", "artifactType": "venture_case", "deliveryLayers": [ "GitHub" ], "validationStage": "scaffold" }, { "title": "R1a Bio-AI Translation Landscape", "sphere": "entrepreneurship", "track": "E3-R1", "entryType": "public case", "status": "active", "summary": "Which ecosystems, conferences, partners, and open communities matter most for translating K R&D Lab work across science, tooling, and applied public cases?", "tags": [ "entrepreneurship", "e3-r1", "s+e+t", "public-case", "r1a", "bio-ai", "translation" ], "links": [ { "label": "README", "href": "https://github.com/K-RnD-Lab/SPHERE-II-ENTREPRENEURSHIP/blob/main/E3%20-%20Ecosystem%2C%20Partnerships%20%26%20External%20Signals/E3-R1%20-%20Ecosystem%20Mapping/R1a-bio-ai-translation-landscape/README.md" }, { "label": "Folder", "href": "https://github.com/K-RnD-Lab/SPHERE-II-ENTREPRENEURSHIP/tree/main/E3%20-%20Ecosystem%2C%20Partnerships%20%26%20External%20Signals/E3-R1%20-%20Ecosystem%20Mapping/R1a-bio-ai-translation-landscape" } ], "primarySphere": "entrepreneurship", "secondarySpheres": [ "science", "technology" ], "combo": "S+E+T", "artifactType": "public_case", "deliveryLayers": [ "GitHub" ], "validationStage": "active_case" }, { "title": "R1a Three-Sphere Research Ops Case", "sphere": "entrepreneurship", "track": "E4-A", "entryType": "public case", "status": "active", "summary": "How should K R&D Lab structure research, tooling, and public-facing artifacts across GitHub and Hugging Face so the whole ecosystem stays navigable, testable, and reusable?", "tags": [ "entrepreneurship", "e4-a", "s+e+t", "public-case", "r1a", "three-sphere", "ops" ], "links": [ { "label": "README", "href": "https://github.com/K-RnD-Lab/SPHERE-II-ENTREPRENEURSHIP/blob/main/E4%20-%20Applied%20Investigations%20%26%20Public%20Cases/E4-A%20-%20Systems%20%26%20Workflow%20Cases/R1a-three-sphere-research-ops-case/README.md" }, { "label": "Folder", "href": "https://github.com/K-RnD-Lab/SPHERE-II-ENTREPRENEURSHIP/tree/main/E4%20-%20Applied%20Investigations%20%26%20Public%20Cases/E4-A%20-%20Systems%20%26%20Workflow%20Cases/R1a-three-sphere-research-ops-case" } ], "primarySphere": "entrepreneurship", "secondarySpheres": [ "science", "technology" ], "combo": "S+E+T", "artifactType": "public_case", "deliveryLayers": [ "GitHub" ], "validationStage": "active_case" }, { "title": "SPHERE-III-TECHNOLOGY", "sphere": "technology", "track": "Root sphere repo", "entryType": "repository", "status": "active", "summary": "Reusable research tools, scoring systems, dashboards, and open infrastructure for K R&D Lab.", "tags": [ "technology", "root sphere repo", "t", "repository", "sphere-iii-technology", "reusable", "tools" ], "links": [ { "label": "Repo", "href": "https://github.com/K-RnD-Lab/SPHERE-III-TECHNOLOGY" }, { "label": "README", "href": "https://github.com/K-RnD-Lab/SPHERE-III-TECHNOLOGY/blob/main/README.md" } ], "primarySphere": "technology", "secondarySpheres": [], "combo": "T", "artifactType": "repository", "deliveryLayers": [ "GitHub" ], "validationStage": "taxonomy" }, { "title": "R1a Bioinformatics Pipeline Template", "sphere": "technology", "track": "T1-R1", "entryType": "study", "status": "scaffold", "summary": "How should K R&D Lab package reusable analytical engines so the same method can support multiple science studies without rewriting the workflow each time?", "tags": [ "technology", "t1-r1", "s+t", "tool", "r1a", "bioinformatics", "pipeline" ], "links": [ { "label": "README", "href": "https://github.com/K-RnD-Lab/SPHERE-III-TECHNOLOGY/blob/main/T1%20-%20Research%20Tools%2C%20ML%20%26%20Analytical%20Engines/T1-R1%20-%20Reusable%20Analytical%20Engines/R1a-bioinformatics-pipeline-template/README.md" }, { "label": "Folder", "href": "https://github.com/K-RnD-Lab/SPHERE-III-TECHNOLOGY/tree/main/T1%20-%20Research%20Tools%2C%20ML%20%26%20Analytical%20Engines/T1-R1%20-%20Reusable%20Analytical%20Engines/R1a-bioinformatics-pipeline-template" } ], "primarySphere": "technology", "secondarySpheres": [ "science" ], "combo": "S+T", "artifactType": "tool", "deliveryLayers": [ "GitHub" ], "validationStage": "prototype" }, { "title": "R1a Study Readiness Scoring", "sphere": "technology", "track": "T2-R1", "entryType": "study", "status": "scaffold", "summary": "How can K R&D Lab score whether a study is ready to move from exploratory computational work into a more reproducible or experimentally actionable stage?", "tags": [ "technology", "t2-r1", "s+t", "scoring-system", "r1a", "readiness", "scoring" ], "links": [ { "label": "README", "href": "https://github.com/K-RnD-Lab/SPHERE-III-TECHNOLOGY/blob/main/T2%20-%20Reproducibility%2C%20Scoring%20%26%20Method%20Systems/T2-R1%20-%20Research%20Gap%20Scoring/R1a-study-readiness-scoring/README.md" }, { "label": "Folder", "href": "https://github.com/K-RnD-Lab/SPHERE-III-TECHNOLOGY/tree/main/T2%20-%20Reproducibility%2C%20Scoring%20%26%20Method%20Systems/T2-R1%20-%20Research%20Gap%20Scoring/R1a-study-readiness-scoring" } ], "primarySphere": "technology", "secondarySpheres": [ "science" ], "combo": "S+T", "artifactType": "scoring_system", "deliveryLayers": [ "GitHub" ], "validationStage": "prototype" }, { "title": "R1a Study Registry Dashboard Template", "sphere": "technology", "track": "T3-R1", "entryType": "study", "status": "scaffold", "summary": "What is the minimal reusable dashboard or registry pattern that can make K R&D Lab studies easier to browse, compare, and audit across spheres?", "tags": [ "technology", "t3-r1", "s+e+t", "dashboard", "r1a", "registry", "minimal" ], "links": [ { "label": "README", "href": "https://github.com/K-RnD-Lab/SPHERE-III-TECHNOLOGY/blob/main/T3%20-%20Dashboards%2C%20Interfaces%20%26%20Open%20Infrastructure/T3-R1%20-%20Dashboard%20Templates%20%26%20Public%20Interfaces/R1a-study-registry-dashboard-template/README.md" }, { "label": "Folder", "href": "https://github.com/K-RnD-Lab/SPHERE-III-TECHNOLOGY/tree/main/T3%20-%20Dashboards%2C%20Interfaces%20%26%20Open%20Infrastructure/T3-R1%20-%20Dashboard%20Templates%20%26%20Public%20Interfaces/R1a-study-registry-dashboard-template" } ], "primarySphere": "technology", "secondarySpheres": [ "science", "entrepreneurship" ], "combo": "S+E+T", "artifactType": "dashboard", "deliveryLayers": [ "GitHub", "Hugging Face" ], "validationStage": "live prototype" } ]