data/seeds/therapy_gold.json

{
  "description": "Hand-labeled gold set of well-known ALS therapies with their established mechanism class(es) from data/seeds/therapy_classes.json. Used by scripts/eval_landscape.py to measure multi-label precision/recall and to calibrate the confidence threshold, and as few-shot exemplars in the classifier prompt. Class names must match therapy_classes.json exactly. 'mechanisms' lists all well-supported classes (first = primary).",
  "gold": [
    {"therapy": "Riluzole", "mechanisms": ["Glutamate excitotoxicity"]},
    {"therapy": "Edaravone", "aliases": ["MCI-186", "MT-1186", "Radicava"], "mechanisms": ["Oxidative stress"]},
    {"therapy": "Tofersen", "aliases": ["Qalsody", "BIIB067"], "mechanisms": ["SOD1"]},
    {"therapy": "CNM-Au8", "mechanisms": ["Mitochondrial dysfunction", "Oxidative stress"]},
    {"therapy": "Arimoclomol", "mechanisms": ["Proteostasis / autophagy"]},
    {"therapy": "AMX0035", "aliases": ["Relyvrio", "sodium phenylbutyrate and taurursodiol"], "mechanisms": ["Mitochondrial dysfunction", "Proteostasis / autophagy"]},
    {"therapy": "Masitinib", "mechanisms": ["Neuroinflammation"]},
    {"therapy": "Ibudilast", "aliases": ["MN-166"], "mechanisms": ["Neuroinflammation"]},
    {"therapy": "NP001", "mechanisms": ["Neuroinflammation"]},
    {"therapy": "Verdiperstat", "aliases": ["AZD3241"], "mechanisms": ["Neuroinflammation", "Oxidative stress"]},
    {"therapy": "RNS60", "mechanisms": ["Neuroinflammation"]},
    {"therapy": "Zilucoplan", "mechanisms": ["Neuroinflammation"]},
    {"therapy": "Ravulizumab", "mechanisms": ["Neuroinflammation"]},
    {"therapy": "Fingolimod", "aliases": ["Gilenya"], "mechanisms": ["Neuroinflammation"]},
    {"therapy": "Dexpramipexole", "mechanisms": ["Mitochondrial dysfunction"]},
    {"therapy": "Rasagiline", "mechanisms": ["Mitochondrial dysfunction", "Oxidative stress"]},
    {"therapy": "Tauroursodeoxycholic acid", "aliases": ["TUDCA", "taurursodiol"], "mechanisms": ["Mitochondrial dysfunction", "Proteostasis / autophagy"]},
    {"therapy": "Olesoxime", "mechanisms": ["Mitochondrial dysfunction"]},
    {"therapy": "Cu(II)ATSM", "aliases": ["CuATSM", "copper ATSM"], "mechanisms": ["Oxidative stress", "Mitochondrial dysfunction"]},
    {"therapy": "Deferiprone", "mechanisms": ["Oxidative stress"]},
    {"therapy": "Ceftriaxone", "mechanisms": ["Glutamate excitotoxicity"]},
    {"therapy": "Talampanel", "mechanisms": ["Glutamate excitotoxicity"]},
    {"therapy": "Memantine", "mechanisms": ["Glutamate excitotoxicity"]},
    {"therapy": "Lithium carbonate", "aliases": ["lithium"], "mechanisms": ["Proteostasis / autophagy"]},
    {"therapy": "Rapamycin", "aliases": ["sirolimus"], "mechanisms": ["Proteostasis / autophagy"]},
    {"therapy": "Trehalose", "mechanisms": ["Proteostasis / autophagy"]},
    {"therapy": "Sodium phenylbutyrate", "mechanisms": ["Proteostasis / autophagy"]},
    {"therapy": "Guanabenz", "mechanisms": ["Proteostasis / autophagy"]},
    {"therapy": "Pridopidine", "mechanisms": ["Neurotrophic / regenerative", "Proteostasis / autophagy"]},
    {"therapy": "Methylcobalamin", "aliases": ["mecobalamin", "E0302"], "mechanisms": ["Neurotrophic / regenerative"]},
    {"therapy": "Fasudil", "mechanisms": ["Neurotrophic / regenerative", "Neuroinflammation"]},
    {"therapy": "NurOwn", "aliases": ["MSC-NTF", "debamestrocel"], "mechanisms": ["Neurotrophic / regenerative"]},
    {"therapy": "Lenzumestrocel", "aliases": ["Neuronata-R"], "mechanisms": ["Neurotrophic / regenerative"]},
    {"therapy": "Ozanezumab", "mechanisms": ["Neurotrophic / regenerative"]},
    {"therapy": "Jacifusen", "aliases": ["ION363"], "mechanisms": ["FUS"]},
    {"therapy": "BIIB078", "mechanisms": ["C9orf72"]},
    {"therapy": "WVE-004", "mechanisms": ["C9orf72"]},
    {"therapy": "SAR443820", "aliases": ["DNL788"], "mechanisms": ["Neuroinflammation"]},
    {"therapy": "Reldesemtiv", "aliases": ["CK-2127107"], "mechanisms": ["Symptomatic / Other"]},
    {"therapy": "Tirasemtiv", "mechanisms": ["Symptomatic / Other"]},
    {"therapy": "Mexiletine", "mechanisms": ["Symptomatic / Other"]},
    {"therapy": "Levosimendan", "mechanisms": ["Symptomatic / Other"]}
  ]
}