""" Claude Sonnet entity extractor. Batches 10 papers per API call; resumable via .progress.json. Uses full_text when available, otherwise abstract. """ from __future__ import annotations import json import time from pathlib import Path import anthropic from rich.progress import BarColumn, MofNCompleteColumn, Progress, TextColumn, TimeElapsedColumn from config import ( ENTITIES_PATH, EXTRACTION_BATCH_SIZE, EXTRACTION_MODEL, EXTRACTION_PROGRESS_PATH, PAPERS_PATH, ) from extraction.normalizer import CanonicalRegistry, normalize_entity from logging_config import get_logger from models import ALSPaper, ExtractedEntity, EntityRelationship, PaperExtractionResult from tools import EXTRACTION_TOOLS _logger = get_logger("extraction.extractor") _EXTRACTION_SYSTEM = """\ You are a biomedical NLP expert specializing in ALS (amyotrophic lateral sclerosis). Extract entities and relationships from each paper using the extract_entities tool. Call it once per paper. Use the full text when provided — it is richer than the abstract alone. Entity types: Gene, Protein, Compound, Pathway, Phenotype, Mechanism. Relationship types: BINDS, INHIBITS, ASSOCIATED_WITH, TESTED_IN, EXPRESSED_IN, CO_OCCURS. Be precise. Only extract entities explicitly mentioned. Return pmid exactly as given. """ def extract_all( papers_path: Path = PAPERS_PATH, entities_path: Path = ENTITIES_PATH, progress_path: Path = EXTRACTION_PROGRESS_PATH, client: anthropic.Anthropic | None = None, ) -> list[PaperExtractionResult]: """Extract entities from all papers. Skips already-processed PMIDs.""" if client is None: client = anthropic.Anthropic() papers = _load_papers(papers_path) done_pmids = _load_progress(progress_path) pending = [p for p in papers if p.pmid not in done_pmids] _logger.info(f"{len(papers)} papers total; {len(done_pmids)} already processed; {len(pending)} pending") if not pending: return [] registry = CanonicalRegistry() entities_path.parent.mkdir(parents=True, exist_ok=True) results: list[PaperExtractionResult] = [] with ( open(entities_path, "a", encoding="utf-8") as out_f, Progress( TextColumn("[cyan]{task.description}[/cyan]"), BarColumn(), MofNCompleteColumn(), TimeElapsedColumn(), ) as progress, ): task = progress.add_task("Extracting entities", total=len(pending)) for i in range(0, len(pending), EXTRACTION_BATCH_SIZE): batch = pending[i : i + EXTRACTION_BATCH_SIZE] batch_results = _extract_batch(client, batch, registry) for result in batch_results: out_f.write(json.dumps(result.to_dict()) + "\n") done_pmids.add(result.pmid) results.append(result) _save_progress(progress_path, done_pmids) registry.save() progress.advance(task, len(batch)) # Respect rate limits between batches if i + EXTRACTION_BATCH_SIZE < len(pending): time.sleep(1.0) return results def _extract_batch( client: anthropic.Anthropic, batch: list[ALSPaper], registry: CanonicalRegistry, ) -> list[PaperExtractionResult]: """Send a batch of papers to Claude and collect one extract_entities call per paper.""" paper_by_pmid = {p.pmid: p for p in batch} content_blocks = _call_claude(client, batch) results: list[PaperExtractionResult] = [] for block in content_blocks: if block.type != "tool_use" or block.name != "extract_entities": continue inp = block.input pmid = str(inp.get("pmid", "")) if not pmid or pmid not in paper_by_pmid: _logger.warning(f"Extracted PMID {pmid!r} not in batch — skipping") continue paper = paper_by_pmid[pmid] entities = _parse_entities(inp.get("entities", []), pmid, registry) relationships = _parse_relationships(inp.get("relationships", []), pmid, registry) result = PaperExtractionResult( pmid=pmid, entities=entities, relationships=relationships, ) results.append(result) _logger.info(f"PMID {pmid}: {len(entities)} entities, {len(relationships)} relationships") # Mark paper entity_names (used downstream by RAG indexer on re-index) paper.entity_names = [e.canonical_id for e in entities] # Retry any papers Claude missed — send them individually found_pmids = {r.pmid for r in results} missed = [p for p in batch if p.pmid not in found_pmids] if missed: _logger.info(f"Retrying {len(missed)} missed papers individually") for paper in missed: retry_results = _call_claude(client, [paper]) for block in retry_results: if block.type != "tool_use" or block.name != "extract_entities": continue inp = block.input pmid = str(inp.get("pmid", "")) if not pmid or pmid not in paper_by_pmid: continue entities = _parse_entities(inp.get("entities", []), pmid, registry) relationships = _parse_relationships(inp.get("relationships", []), pmid, registry) results.append(PaperExtractionResult(pmid=pmid, entities=entities, relationships=relationships)) paper_by_pmid[pmid].entity_names = [e.canonical_id for e in entities] found_pmids.add(pmid) _logger.info(f"Retry succeeded for PMID {pmid}") time.sleep(0.5) # Any still-missing after retry → record empty so they're not re-attempted for p in batch: if p.pmid not in found_pmids: _logger.warning(f"No extraction result for PMID {p.pmid} after retry — recording empty") results.append(PaperExtractionResult(pmid=p.pmid, entities=[], relationships=[])) return results def _call_claude(client: anthropic.Anthropic, batch: list[ALSPaper]) -> list: """Raw Claude call — returns response.content blocks.""" try: response = client.messages.create( model=EXTRACTION_MODEL, max_tokens=4096, system=_EXTRACTION_SYSTEM, tools=EXTRACTION_TOOLS, tool_choice={"type": "any"}, messages=[{"role": "user", "content": _format_batch(batch)}], ) return response.content except anthropic.RateLimitError: _logger.warning("Rate limited — sleeping 30s") time.sleep(30) response = client.messages.create( model=EXTRACTION_MODEL, max_tokens=4096, system=_EXTRACTION_SYSTEM, tools=EXTRACTION_TOOLS, tool_choice={"type": "any"}, messages=[{"role": "user", "content": _format_batch(batch)}], ) return response.content def _format_batch(batch: list[ALSPaper]) -> str: parts = [ f"Extract entities from each of the following {len(batch)} ALS papers. " "Call extract_entities once per paper.\n" ] for paper in batch: text = paper.full_text if paper.full_text else paper.abstract # Cap at 3000 chars to stay within token budget for a 10-paper batch excerpt = text[:3000] if text else paper.abstract[:1000] parts.append( f"--- PMID:{paper.pmid} ---\n" f"Title: {paper.title}\n\n" f"{excerpt}\n" ) return "\n".join(parts) def _parse_entities( raw: list[dict], pmid: str, registry: CanonicalRegistry, ) -> list[ExtractedEntity]: entities = [] for item in raw: name = item.get("name", "").strip() entity_type = item.get("type", "").strip() if not name or not entity_type: continue canonical_id = registry.resolve(name, entity_type) entities.append( ExtractedEntity( type=entity_type, name=name, canonical_id=canonical_id, confidence=float(item.get("confidence", 0.7)), mentions=int(item.get("mentions", 1)), ) ) return entities def _parse_relationships( raw: list[dict], pmid: str, registry: CanonicalRegistry, ) -> list[EntityRelationship]: rels = [] for item in raw: source_name = item.get("source", "").strip() target_name = item.get("target", "").strip() rel_type = item.get("type", "").strip() if not source_name or not target_name or not rel_type: continue # We don't know entity types for source/target here — infer from name source_id = registry.resolve(source_name, _guess_type(source_name)) target_id = registry.resolve(target_name, _guess_type(target_name)) rels.append( EntityRelationship( source=source_id, target=target_id, relation_type=rel_type, evidence_pmids=[pmid], confidence=0.7, evidence_text=item.get("evidence_text", "")[:300], ) ) return rels def _guess_type(name: str) -> str: """Best-effort entity type guess from name for relationship source/target.""" from extraction.normalizer import _GENE_ALIASES, _COMPOUND_ALIASES if name.strip().upper() in _GENE_ALIASES or name.strip() in _GENE_ALIASES: return "Gene" if name.strip() in _COMPOUND_ALIASES: return "Compound" return "Protein" def _load_papers(path: Path) -> list[ALSPaper]: papers = [] with open(path, encoding="utf-8") as f: for line in f: line = line.strip() if line: papers.append(ALSPaper.from_dict(json.loads(line))) return papers def _load_progress(path: Path) -> set[str]: if path.exists(): return set(json.loads(path.read_text())) return set() def _save_progress(path: Path, done: set[str]) -> None: path.parent.mkdir(parents=True, exist_ok=True) path.write_text(json.dumps(sorted(done)))