{
  "genes": [
    "SOD1", "TARDBP", "FUS", "C9orf72", "ATXN2",
    "TBK1", "OPTN", "UBQLN2", "VCP", "NEK1",
    "ANG", "SETX", "SIGMAR1", "CHCHD10", "MATR3"
  ],
  "proteins": [
    "TDP-43", "FUS protein", "SOD1 protein", "Alsin",
    "Optineurin", "p62", "Ubiquilin-2"
  ],
  "compounds": [
    "riluzole", "edaravone", "tofersen", "AMX0035",
    "mexiletine", "masitinib", "bosutinib"
  ],
  "mechanisms": [
    "glutamate excitotoxicity", "oxidative stress",
    "neuroinflammation", "protein aggregation",
    "RNA metabolism dysfunction", "mitochondrial dysfunction",
    "axonal transport defect", "autophagy impairment"
  ],
  "phenotypes": [
    "upper motor neuron degeneration", "lower motor neuron degeneration",
    "bulbar onset ALS", "spinal onset ALS",
    "frontotemporal dementia", "respiratory failure"
  ]
}