"""
Output Normalization Layer.

This module is responsible for normalizing LLM outputs into structured,
consistent data suitable for report generation. It handles:
1. Terminology standardization (CN/EN)
2. Tone normalization (removing casual language)
3. Uncertainty annotation
4. Structure extraction from natural language

Design Philosophy:
- The LLM output is treated as "raw material" that needs refinement
- Normalization ensures consistency regardless of model variations
- Forbidden phrases are filtered to maintain professional tone
"""

import re
from typing import Optional, List, Dict, Any
from datetime import datetime
import json

from schemas.canonical_schema import (
    AnalysisResult,
    ReactiveGroup,
    PhysicochemicalProperties,
    ExcipientProfile,
    InteractionMechanism,
    FormulationStrategy,
    BilingualText,
    RiskLevel,
    ConfidenceLevel,
    PropertyType,
    ImpurityProfile,
)
from config.settings import settings


class OutputNormalizer:
    """
    Normalizes LLM outputs into structured report-ready data.
    
    This class takes raw text from LLM responses and transforms it into
    the AnalysisResult schema, ensuring consistency and filtering
    inappropriate content.
    """
    
    def __init__(self):
        """Initialize the normalizer with configuration."""
        self.terminology_map = settings.output.terminology_map
        self.forbidden_phrases = settings.output.forbidden_phrases
        self.risk_level_keywords = {
            RiskLevel.NONE: ["无风险", "no risk", "不具备", "不存在"],
            RiskLevel.LOW: ["低风险", "low risk", "轻微", "可控"],
            RiskLevel.MEDIUM: ["中等", "需关注", "medium", "moderate", "关注"],
            RiskLevel.HIGH: ["高风险", "high risk", "显著", "严重"],
        }
    
    def normalize(
        self,
        api_name: str,
        api_smiles: Optional[str],
        excipient_name: str,
        raw_outputs: Dict[str, str],
    ) -> AnalysisResult:
        """
        Normalize all raw LLM outputs into a structured AnalysisResult.
        
        Args:
            api_name: Name of the API
            api_smiles: SMILES notation of the API
            excipient_name: Name of the primary excipient
            raw_outputs: Dictionary of raw outputs by dimension
            
        Returns:
            AnalysisResult: Fully structured and normalized result
        """
        # Generate report metadata
        report_id = self._generate_report_id()
        date = datetime.now().strftime("%Y-%m-%d")
        
        # Normalize each dimension
        reactive_groups = self._extract_reactive_groups(
            raw_outputs.get("api_structure", "")
        )
        
        physicochemical = self._extract_physicochemical(
            raw_outputs.get("api_structure", "")
        )
        
        excipient_profile = self._extract_excipient_profile(
            raw_outputs.get("excipient_analysis", ""),
            excipient_name
        )
        
        interactions = self._extract_interactions(
            raw_outputs.get("compatibility", "")
        )
        
        strategies = self._extract_formulation_strategies(
            raw_outputs.get("compatibility", "") + 
            raw_outputs.get("synthesis", "")
        )
        
        # Extract uncertainty information
        assumptions, limitations = self._extract_uncertainties(
            raw_outputs.get("synthesis", "")
        )
        
        return AnalysisResult(
            report_id=report_id,
            date=date,
            api_name=api_name,
            api_smiles=api_smiles,
            excipient_name=excipient_name,
            reactive_groups=reactive_groups,
            physicochemical=physicochemical,
            excipient_profile=excipient_profile,
            interactions=interactions,
            formulation_strategies=strategies,
            assumptions=assumptions,
            limitations=limitations,
            data_sources=["药典通用知识", "ICH指南原则", "结构活性关系分析"],
        )
    
    def normalize_text(self, text: str) -> str:
        """
        Normalize a piece of text by applying terminology mapping
        and removing forbidden phrases.
        
        Args:
            text: Raw text to normalize
            
        Returns:
            Normalized text
        """
        result = text
        
        # Apply terminology standardization
        for original, replacement in self.terminology_map.items():
            result = result.replace(original, f"{original} ({replacement})")
        
        # Remove forbidden phrases
        for phrase in self.forbidden_phrases:
            result = re.sub(
                rf'\b{re.escape(phrase)}\b',
                '',
                result,
                flags=re.IGNORECASE
            )
        
        # Clean up extra whitespace
        result = re.sub(r'\s+', ' ', result).strip()
        
        return result
    
    def _generate_report_id(self) -> str:
        """Generate a unique report ID."""
        prefix = settings.report.id_prefix
        timestamp = datetime.now().strftime("%Y-%m%d")
        # Simple counter - in production would use proper sequence
        import random
        seq = f"X{random.randint(10, 99)}"
        return f"{prefix}-{timestamp}-{seq}"
    
    def _extract_reactive_groups(self, text: str) -> List[ReactiveGroup]:
        """Extract reactive group information from API analysis."""
        groups = []
        
        # Pattern-based extraction for common group types
        group_patterns = [
            (r"伯胺[基团]*\s*\(Primary\s*Amine\)", "伯胺基团", "Primary Amine", PropertyType.BASIC),
            (r"仲胺[基团]*\s*\(Secondary\s*Amine\)", "仲胺基团", "Secondary Amine", PropertyType.BASIC),
            (r"硫醚[基团]*\s*\(Thioether\)", "硫醚基团", "Thioether", PropertyType.NEUTRAL),
            (r"酚羟基\s*\(Phenolic\s*Hydroxyl\)", "酚羟基", "Phenolic Hydroxyl", PropertyType.ACIDIC),
            (r"羧基\s*\(Carboxyl\)", "羧基", "Carboxyl Group", PropertyType.ACIDIC),
            (r"芳香杂环\s*\(Aromatic\s*Heterocycle", "芳香杂环", "Aromatic Heterocycle", PropertyType.BASIC),
        ]
        
        for pattern, cn_name, en_name, prop_type in group_patterns:
            if re.search(pattern, text, re.IGNORECASE):
                # Extract potential reactions for this group
                reactions = self._extract_reactions_for_group(cn_name, text)
                
                groups.append(ReactiveGroup(
                    name=BilingualText(cn=cn_name, en=en_name),
                    property_type=prop_type,
                    potential_reactions=reactions,
                ))
        
        # If no groups found, create a default entry
        if not groups:
            groups.append(ReactiveGroup(
                name=BilingualText(cn="待分析", en="Pending Analysis"),
                property_type=PropertyType.NEUTRAL,
                potential_reactions=[],
            ))
        
        return groups
    
    def _extract_reactions_for_group(
        self, 
        group_name: str, 
        text: str
    ) -> List[BilingualText]:
        """Extract potential reactions associated with a functional group."""
        reactions = []
        
        # Common reaction mappings
        reaction_map = {
            "伯胺": [
                ("美拉德反应", "Maillard Reaction"),
                ("氧化脱氨", "Oxidative Deamination"),
                ("席夫碱形成", "Schiff Base Formation"),
            ],
            "硫醚": [
                ("氧化成亚砜", "Oxidation to Sulfoxide"),
                ("氧化成砜", "Oxidation to Sulfone"),
            ],
            "酚羟基": [
                ("氧化", "Oxidation"),
                ("光氧化", "Photooxidation"),
            ],
        }
        
        for key, rxn_list in reaction_map.items():
            if key in group_name:
                for cn, en in rxn_list:
                    reactions.append(BilingualText(cn=cn, en=en))
        
        return reactions
    
    def _extract_physicochemical(self, text: str) -> Optional[PhysicochemicalProperties]:
        """Extract physicochemical properties from analysis."""
        # Default values - would be parsed from text in full implementation
        acidity = BilingualText(cn="碱性", en="Basic")
        
        # Try to extract LogP
        logp_match = re.search(r'LogP[:\s~约]*([0-9.]+)', text)
        logp = float(logp_match.group(1)) if logp_match else None
        
        # Try to extract H-bond donors/acceptors
        hbd_match = re.search(r'氢键供体[:\s]*(\d+)', text)
        hba_match = re.search(r'氢键受体[:\s]*(\d+)', text)
        
        return PhysicochemicalProperties(
            acidity_basicity=acidity,
            logp=logp,
            h_bond_donors=int(hbd_match.group(1)) if hbd_match else None,
            h_bond_acceptors=int(hba_match.group(1)) if hba_match else None,
            risk_profile="含多个碱性氮原子，硫醚对氧化敏感" if "硫醚" in text else None,
        )
    
    def _extract_excipient_profile(
        self, 
        text: str, 
        excipient_name: str
    ) -> Optional[ExcipientProfile]:
        """Extract excipient profile from analysis."""
        # Extract formula if present
        formula_match = re.search(r'化学式[:\s]*([A-Za-z0-9₀-₉]+)', text)
        formula = formula_match.group(1) if formula_match else None
        
        # Extract key properties
        key_properties = []
        if "直接压片" in text:
            key_properties.append("适合直接压片工艺")
        if "低吸湿性" in text or "<1%" in text:
            key_properties.append("低吸湿性(<1% at 90% RH)")
        if "pH" in text:
            key_properties.append("微环境pH约为6.5-7.5")
        
        # Try to extract impurity info
        impurity_profile = None
        if "Fe" in text or "金属离子" in text:
            impurity_profile = ImpurityProfile(
                fe_ppm=10.0,  # Typical value
                mn_ppm=1.0,   # Typical value
            )
        
        return ExcipientProfile(
            name=BilingualText(
                cn=excipient_name,
                en=self._translate_excipient_name(excipient_name)
            ),
            formula=formula,
            key_properties=key_properties,
            impurity_profile=impurity_profile,
            microenvironment="弱碱性环境" if "碱性" in text else None,
            compatibility_notes=self.normalize_text(text[:200]) if text else None,
        )
    
    def _translate_excipient_name(self, cn_name: str) -> str:
        """Translate common excipient names to English."""
        translations = {
            "无水磷酸氢钙": "DCP Anhydrous",
            "磷酸氢钙": "Dibasic Calcium Phosphate",
            "乳糖": "Lactose",
            "微晶纤维素": "Microcrystalline Cellulose",
            "硬脂酸镁": "Magnesium Stearate",
            "淀粉": "Starch",
            "甘露醇": "Mannitol",
        }
        return translations.get(cn_name, cn_name)
    
    def _extract_interactions(self, text: str) -> List[InteractionMechanism]:
        """Extract interaction mechanisms from compatibility analysis."""
        interactions = []
        
        # Define interaction types to look for
        interaction_types = [
            ("美拉德反应", "Maillard Reaction"),
            ("氧化反应", "Oxidation"),
            ("酸碱反应", "Acid-Base Interaction"),
            ("水解反应", "Hydrolysis"),
            ("吸附作用", "Adsorption"),
        ]
        
        for cn_name, en_name in interaction_types:
            # Check if this interaction type is discussed
            if cn_name in text:
                # Determine risk level from context
                risk = self._determine_risk_level(text, cn_name)
                
                # Extract mechanism analysis
                mechanism = self._extract_mechanism_for_type(text, cn_name)
                
                # Extract expert notes
                expert_notes = self._extract_expert_notes(text, cn_name)
                
                interactions.append(InteractionMechanism(
                    reaction_type=BilingualText(cn=cn_name, en=en_name),
                    risk_level=risk,
                    mechanism_analysis=mechanism,
                    expert_notes=expert_notes,
                    confidence=ConfidenceLevel.MEDIUM,
                ))
        
        return interactions
    
    def _determine_risk_level(self, text: str, reaction_type: str) -> RiskLevel:
        """Determine risk level for a specific reaction type from text."""
        # Find the section about this reaction type
        # Simple heuristic: look for risk keywords near the reaction type mention
        
        # Search window around the reaction type
        idx = text.find(reaction_type)
        if idx == -1:
            return RiskLevel.MEDIUM
        
        window = text[max(0, idx-50):min(len(text), idx+200)]
        
        for level, keywords in self.risk_level_keywords.items():
            for keyword in keywords:
                if keyword in window.lower():
                    return level
        
        return RiskLevel.MEDIUM
    
    def _extract_mechanism_for_type(self, text: str, reaction_type: str) -> str:
        """Extract mechanism analysis for a specific reaction type."""
        # Look for mechanism description after the reaction type
        patterns = [
            rf'{reaction_type}.*?机制分析[:\s]*([^#]+?)(?=\n\n|\n###|\n##|$)',
            rf'{reaction_type}.*?(?:因为|由于|主要是)([^。]+。)',
        ]
        
        for pattern in patterns:
            match = re.search(pattern, text, re.DOTALL)
            if match:
                return self.normalize_text(match.group(1)[:300])
        
        return "请参阅详细分析报告"
    
    def _extract_expert_notes(self, text: str, reaction_type: str) -> str:
        """Extract expert commentary for a reaction type."""
        patterns = [
            rf'{reaction_type}.*?专家点评[:\s]*([^#\n]+)',
            rf'{reaction_type}.*?建议[:\s]*([^#\n]+)',
        ]
        
        for pattern in patterns:
            match = re.search(pattern, text, re.DOTALL)
            if match:
                return self.normalize_text(match.group(1)[:200])
        
        return "需结合实验数据进一步评估"
    
    def _extract_formulation_strategies(self, text: str) -> List[FormulationStrategy]:
        """Extract formulation strategy recommendations."""
        strategies = []
        
        # Look for numbered recommendations
        pattern = r'(\d+)\.\s*\*\*([^*]+)\*\*[:\s]*([^\n]+)'
        matches = re.findall(pattern, text)
        
        for _, title, description in matches[:5]:  # Limit to 5 strategies
            strategies.append(FormulationStrategy(
                title=self.normalize_text(title.strip()),
                description=self.normalize_text(description.strip()),
            ))
        
        # Add default strategies if none found
        if not strategies:
            strategies = [
                FormulationStrategy(
                    title="辅料选择优化",
                    description="建议选用低金属离子规格辅料",
                ),
                FormulationStrategy(
                    title="稳定剂考虑",
                    description="根据风险评估结果考虑添加适当稳定剂",
                ),
            ]
        
        return strategies
    
    def _extract_uncertainties(self, text: str) -> tuple:
        """Extract assumptions and limitations from synthesis."""
        assumptions = []
        limitations = []
        
        # Extract assumptions
        assumption_pattern = r'假设[:\s]*([^。\n]+)'
        for match in re.finditer(assumption_pattern, text):
            assumptions.append(match.group(1).strip())
        
        # Extract limitations
        limitation_pattern = r'局限[:\s]*([^。\n]+)'
        for match in re.finditer(limitation_pattern, text):
            limitations.append(match.group(1).strip())
        
        # Default values if none found
        if not assumptions:
            assumptions = [
                "分析基于SMILES结构推断",
                "假设正常制剂工艺条件",
            ]
        
        if not limitations:
            limitations = [
                "具体批次数据需COA确认",
                "相容性结论需稳定性试验验证",
            ]
        
        return assumptions, limitations