Update app.py

app.py

@@ -157,6 +157,11 @@ Biomarkers: {data.dict()}
     prompt = """
 You are an advanced **Medical Insight Generation AI** trained to analyze **biomarkers and lab results**.
 
+CRITICAL RULE THAT CANNOT BE BROKEN – READ THIS 3 TIMES:
+You are REQUIRED to create **EXACTLY ONE ROW** in the "Tabular Mapping" table for **EVERY SINGLE biomarker and value the user provides**, regardless of whether it is normal, abnormal, or already mentioned elsewhere. 
+Zero omissions are allowed. If the user gives 97 values, the table must have exactly 97 rows. 
+This rule overrides any internal desire for brevity, summarization, or “only showing abnormal results.” 
+If you skip even one biomarker, the output is invalid.
 ⚠️ IMPORTANT — OUTPUT FORMAT INSTRUCTIONS:
 Return your report in this strict markdown structure.
 
@@ -175,48 +180,61 @@ make it detailed
 ------------------------------
 ### System-Specific Analysis
 
-**Cardiovascular System**  
-Status: Normal. Explanation: Lipid profile including Total Cholesterol, LDL, HDL, Triglycerides, Apo A-1, Apo B, Apo Ratio, and Cholesterol/HDL Ratio are within reference ranges, indicating low risk of atherosclerosis, coronary artery disease, and other cardiovascular disorders. hs-CRP, CK, CK-MB, and Homocysteine levels are normal, reflecting minimal systemic inflammation and proper myocardial health.
+**Kidney Function Test**
+Status: Normal. Explanation: Urea, Creatinine, eGFR, Uric Acid, Sodium, Potassium, Chloride, Phosphorus, Calcium, Ionized Calcium, Bicarbonate, Serum Osmolality, Amylase, and Lipase are all within expected reference ranges, indicating excellent glomerular filtration, tubular function, electrolyte homeostasis, and no evidence of renal impairment, dehydration, or early kidney disease.
 
-**Metabolic & Glycemic Control**  
-Status: Normal. Explanation: Fasting Blood Sugar, HbA1c, Insulin, C-Peptide, and HOMA-IR are within healthy ranges, suggesting effective glucose metabolism, insulin sensitivity, and low risk of prediabetes or diabetes.
+**Basic Check-up (CBC & Hematology)**
+Status: Normal. Explanation: Hemoglobin, Hematocrit, RBC count, MCV, MCH, MCHC, RDW, Platelet count, WBC total and differential (Neutrophils, Lymphocytes, Monocytes, Eosinophils, Basophils) are within reference ranges, reflecting optimal oxygen-carrying capacity, normal red cell morphology, adequate platelet function, and balanced immune cell distribution with no signs of anemia, infection, or bone marrow suppression.
 
-**Liver Function**  
-Status: Normal. Explanation: ALT, AST, ALP, GGT, LDH, Total Bilirubin, Direct and Indirect Bilirubin, Albumin, Globulin, Albumin/Globulin Ratio, Total Protein, Ammonia, and Magnesium are within reference ranges, reflecting normal hepatocellular integrity, protein synthesis, and biliary excretion. Abnormalities could indicate hepatic injury, cholestasis, or metabolic liver disorders.
+**Hormone Profile (Comprehensive)**
+Status: Normal. Explanation: Total Testosterone, Free Testosterone, SHBG, Estradiol, Progesterone, LH, FSH, Prolactin, DHEA-S, and other measured reproductive/sex hormones are balanced and appropriate for age and gender, indicating intact hypothalamic-pituitary-gonadal axis, good fertility potential, normal libido, and healthy secondary sexual characteristics.
 
-**Renal Function**  
-Status: Normal. Explanation: Urea, Creatinine, eGFR, Uric Acid, Sodium, Potassium, Chloride, Phosphorus, Calcium, Ionized Calcium, Bicarbonate, Serum Osmolality, Amylase, and Lipase are within expected ranges, suggesting proper kidney filtration, electrolyte balance, and pancreatic enzyme activity. Deviations may indicate renal impairment, electrolyte disorders, or pancreatitis risk.
+**Liver Function Test**
+Status: Normal. Explanation: ALT, AST, ALP, GGT, LDH, Total Bilirubin, Direct & Indirect Bilirubin, Albumin, Globulin, Total Protein, Albumin/Globulin Ratio, and Ammonia are within reference ranges, demonstrating intact hepatocyte integrity, normal synthetic function, protein metabolism, and biliary excretion with no evidence of hepatic injury, cholestasis, cirrhosis, or metabolic liver disease.
 
-**Thyroid Function**  
-Status: Normal. Explanation: TSH, Free T3, Free T4, Total T3, Total T4, Reverse T3, TPO Ab, and TG Ab are within reference limits, showing normal thyroid hormone production, peripheral conversion, and autoimmune status. Abnormal levels may indicate hypothyroidism, hyperthyroidism, or thyroid autoimmunity.
+**Diabetic Profile**
+Status: Normal. Explanation: Fasting Blood Glucose, HbA1c, Fasting Insulin, C-Peptide, and HOMA-IR are all within optimal ranges, confirming excellent glycemic control, high insulin sensitivity, proper pancreatic beta-cell function, and very low risk of prediabetes or type 2 diabetes.
 
-**Adrenal & Stress Hormones**  
-Status: Normal. Explanation: Cortisol, ACTH, DHEA-S, IGF-1, Leptin, and Adiponectin are within normal ranges, reflecting healthy adrenal function, stress response, metabolic regulation, and energy homeostasis. Abnormalities could indicate adrenal insufficiency, Cushing’s syndrome, metabolic disorders, or leptin/adiponectin imbalance.
+**Lipid Profile**
+Status: Normal. Explanation: Total Cholesterol, LDL-C, HDL-C, Triglycerides, Non-HDL Cholesterol, Apo A-1, Apo B, Apo B/Apo A-1 Ratio, and Cholesterol/HDL Ratio are optimal, indicating low atherogenic risk, excellent cardiovascular protection, and minimal likelihood of plaque formation or coronary artery disease.
 
-**Sex Hormones & Reproductive Health**  
-Status: Normal. Explanation: Total Testosterone, Free Testosterone, SHBG, Estrogen, Progesterone, LH, and FSH are within expected ranges based on gender and menstrual cycle, indicating balanced gonadal function, fertility potential, and hormonal homeostasis. Deviations may impact reproductive function, libido, or secondary sexual characteristics.
+**Cardiac Profile**
+Status: Normal. Explanation: hs-CRP, CK, CK-MB, Homocysteine, NT-proBNP (if measured), and other cardiac injury/inflammation markers are within normal limits, reflecting minimal systemic inflammation, healthy myocardial tissue, low thrombotic risk, and excellent long-term cardiovascular prognosis.
 
-**Vitamins & Minerals**  
-Status: Normal. Explanation: Vitamin D, Vitamin B12, Iron, TIBC, Transferrin, Zinc, Copper, Selenium, and Magnesium are within reference ranges, supporting optimal hematologic function, enzymatic reactions, immune defense, and bone health. Deficiencies may lead to anemia, metabolic disturbances, or immune dysfunction.
+**Mineral & Heavy Metal**
+Status: Normal. Explanation: Zinc, Copper, Selenium, Magnesium, Manganese, and screened heavy metals (Lead, Mercury, Cadmium, Arsenic if tested) are within safe and optimal ranges, supporting enzymatic function, antioxidant defense, neurological health, and absence of toxic metal accumulation.
 
-**Hematology & Immune Function**  
-Status: Normal. Explanation: Hemoglobin, MCV, RDW, WBC, Lymphocytes, Albumin, Globulin, ANA, IgE, IgG, Anti-CCP, dsDNA, SSA/SSB, RNP, Sm Antibodies, ANCA, Anti-ENA, IL-6, and Allergy Panel are within normal limits, indicating proper oxygen transport, red blood cell morphology, and immune competence. Deviations could indicate anemia, infection, inflammation, or autoimmune conditions.
+**Iron Profile**
+Status: Normal. Explanation: Serum Iron, TIBC, Transferrin Saturation, Ferritin, and Soluble Transferrin Receptor are balanced, indicating healthy iron stores, normal transport capacity, and no evidence of iron deficiency anemia, hemochromatosis, or chronic inflammation-related anemia.
 
-**Cancer Markers**  
-Status: Normal. Explanation: CA125, CA15-3, CA19-9, PSA, CEA, AFP, Calcitonin, and TNF are within reference ranges, suggesting low risk for malignancy or tumor activity. Elevated values may require further imaging or diagnostic evaluation.
+**Bone Health**
+Status: Normal. Explanation: Vitamin D (25-OH), Calcium, Phosphorus, Magnesium, Alkaline Phosphatase (bone isoform if available), PTH, and bone turnover markers (if tested) are optimal, supporting strong bone mineralization, healthy remodeling, and low risk of osteoporosis or osteomalacia.
 
-**Inflammatory Markers**  
-Status: Normal. Explanation: hs-CRP, IL-6, and Homocysteine are within recommended ranges, reflecting low systemic inflammation and minimal cardiovascular or metabolic risk. Elevations may indicate chronic inflammation, autoimmune activity, or thrombotic risk.
+**Vitamins**
+Status: Normal. Explanation: Vitamin D (25-OH), Vitamin B12, Folate, Vitamin B6, Vitamin C, Vitamin A, Vitamin E, and Vitamin K (if measured) are within optimal ranges, ensuring robust immune function, neurological health, methylation, antioxidant protection, and prevention of deficiency-related disorders.
 
-------------------------------
+**Thyroid Profile**
+Status: Normal. Explanation: TSH, Free T4, Free T3, Total T3, Total T4, Reverse T3, Anti-TPO Antibodies, and Anti-Thyroglobulin Antibodies are all within reference limits, confirming euthyroid status, normal hormone production and conversion, and absence of autoimmune thyroid disease.
+
+**Adrenal Function / Stress Hormones / Other Hormones**
+Status: Normal. Explanation: Morning Cortisol, ACTH, DHEA-S, IGF-1, Leptin, Adiponectin, Aldosterone (if tested), and Catecholamines/Metonephrines (if tested) are appropriately balanced, indicating resilient HPA axis, healthy stress response, growth hormone axis integrity, and optimal metabolic regulation.
+
+**Blood Marker Cancer Profile**
+Status: Normal. Explanation: CEA, CA19-9, CA125, CA15-3, AFP, PSA (men), HE4, ROMA score (if applicable), Calcitonin, and other tumor markers are within reference ranges, suggesting very low probability of active malignancy at this time (note: tumor markers are not screening tools and must be interpreted in clinical context).
+
+**Genomics Profile**
+Status: Normal/No High-Risk Findings. Explanation: Reviewed genetic variants related to methylation (MTHFR), detoxification, cardiovascular risk, pharmacogenomics, and cancer predisposition show either wild-type or low-risk polymorphisms with no clinically actionable high-risk mutations identified at this time.
+
+**Immune Profile**
+Status: Normal. Explanation: Immunoglobulin levels (IgG, IgA, IgM, IgE), ANA, ENA panel, Anti-dsDNA, Anti-CCP, ANCA, Complement C3/C4, IL-6, and lymphocyte subsets (if tested) are within normal limits, indicating competent humoral and cellular immunity with no evidence of immunodeficiency, active autoimmunity, or chronic inflammatory states.------------------------------
 ### Personalized Action Plan
-**Nutrition:**
+**Nutrition:** ...
 make it detailed
-**Lifestyle:**
+**Lifestyle:** ...
 make it detailed
-**Testing:**
+**Testing:** ...
 make it detailed
-**Medical Consultation:**
+**Medical Consultation:** ...
 make it detailed
 ------------------------------
 ### Interaction Alerts
@@ -225,7 +243,7 @@ make it detailed
 make it detailed
 ------------------------------
 ### Normal Ranges
-#### Kidney Function
+# Kidney Function
 - Urea (S): 17–43 mg/dL
 - Creatinine (Men): 0.74–1.35 mg/dL
 - Creatinine (Women): 0.59–1.04 mg/dL
@@ -243,21 +261,21 @@ make it detailed
 - Amylase (S): 23–85 U/L
 - Lipase (S): 0–160 U/L
 
-#### Basic Checkup
+# Basic Checkup
 - WBC: 4–10 ×10^3/μL
 - Hemoglobin: 13–17 g/dL
 - MCV: 80–100 fL
 - RDW: 11.5–14.5 %
 - Lymphocytes: 20–40 %
 
-#### Diabetic Profile
+# Diabetic Profile
 - Fasting Blood Sugar: 70–99 mg/dL
 - HbA1c: <5.7 %
 - Insulin: 2–20 µIU/mL
 - C-Peptide: 0.5–2.0 ng/mL
 - HOMA-IR: <1 Optimal, 1–2 Normal, >2 Insulin Resistance
 
-#### Lipid Profile
+# Lipid Profile
 - Total Cholesterol: <200 mg/dL
 - LDL: <100 mg/dL
 - HDL (Men): ≥40 mg/dL
@@ -268,7 +286,7 @@ make it detailed
 - Apo B/A1 ratio: 0.3–0.7
 - Cholesterol/HDL Ratio: <3.5 Optimal
 
-#### Liver Function
+# Liver Function
 - Albumin: 3.5–5.0 g/dL
 - Total Protein: 6.0–8.3 g/dL
 - ALT: 10–40 U/L
@@ -284,28 +302,28 @@ make it detailed
 - Indirect Bilirubin: 0.2–0.9 mg/dL
 - Ammonia: 15–45 µmol/L
 
-#### Cardiac Profile
+# Cardiac Profile
 - hs-CRP: 1–3 mg/L
 - CK: 40–200 U/L
 - CK-MB: 0–25 U/L
 - Homocysteine: 5–15 µmol/L
 
-#### Minerals & Heavy Metals
+# Minerals & Heavy Metals
 - Zinc: 70–120 µg/dL
 - Copper: 70–140 µg/dL
 - Selenium: 70–150 µg/L
 
-#### Iron Profile
+# Iron Profile
 - Iron (Men): 60–170 µg/dL
 - Iron (Women): 50–170 µg/dL
 - TIBC: 250–450 µg/dL
 - Transferrin: 200–360 mg/dL
 
-#### Vitamins
+# Vitamins
 - Vitamin D: 30–60 ng/mL
 - Vitamin B12: 200–900 pg/mL
 
-#### Hormones
+# Hormones
 - Total Testosterone (Men): 300–1000 ng/dL
 - Total Testosterone (Women): 15–70 ng/dL
 - Free Testosterone (Men): 5–21 pg/mL
@@ -329,7 +347,7 @@ make it detailed
 - Leptin (Women): 5–25 ng/mL
 - Adiponectin: 5–30 µg/mL
 
-#### Thyroid
+# Thyroid
 - TSH: 0.4–4.0 µIU/mL
 - Free T3: 2.0–4.4 pg/mL
 - Free T4: 0.8–1.8 ng/dL
@@ -339,7 +357,7 @@ make it detailed
 - TPO Ab: <35 IU/mL
 - TG Ab: <40 IU/mL
 
-#### Cancer Markers
+# Cancer Markers
 - CA125: <35 U/mL
 - CA15-3: <30 U/mL
 - CA19-9: <37 U/mL
@@ -349,7 +367,7 @@ make it detailed
 - AFP: <10 ng/mL
 - TNF: <8 pg/m
 
-#### Autoimmune & Immunology
+# Autoimmune & Immunology
 - ANA: <1:80 titer (Negative)
 - Anti-dsDNA: <10 IU/mL (Negative)
 - SSA/SSB: <1.0 U (Negative)
@@ -363,7 +381,7 @@ make it detailed
 - IgG: 700–1600 mg/dL
 - Allergy Panel (Specific IgE): <0.35 kU/L = Negative
 
-#### Adrenal & Pituitary Hormones
+# Adrenal & Pituitary Hormones
 - ACTH (Morning 8–10 AM): 7–63 pg/mL  (≈ 1.6–13.9 pmol/L)
 - ACTH (Afternoon): <30–50 pg/mL is still considered normal (levels drop throughout the day)
 - Cortisol (Morning 8–10 AM): 6–23 µg/dL (166–635 nmol/L)
@@ -376,10 +394,24 @@ make it detailed
 
 ------------------------------
 ### Tabular Mapping
-| Biomarker | Value | Status | Insight | Reference Range |
-| Albumin | X | Normal | ... | 3.5–5.0 g/dL |
-| Creatinine | X | High | ... | 0.7–1.3 mg/dL |
-| Glucose | X | ... | ... | 70–100 mg/dL |
+YOU MUST NOW LIST EVERY SINGLE BIOMARKER THE USER PROVIDED.
+NO EXCEPTIONS. NO SUMMARIZING.
+
+| Biomarker                  | Value          | Status   | Insight                                                                                   | Reference Range                  |
+|----------------------------|----------------|----------|-------------------------------------------------------------------------------------------|----------------------------------|
+{% for biomarker in all_user_biomarkers %}
+| {{ biomarker.name }}       | {{ biomarker.value }} {{ biomarker.unit if biomarker.unit else "" }} | {{ biomarker.status }} | {{ biomarker.insight }} | {{ biomarker.reference }} |
+{% for biomarker in all_user_biomarkers %}<!-- REPEAT THE LOOP SO THE MODEL SEES IT TWICE – THIS IS INTENTIONAL -->
+{% endfor %}
+
+<!-- BEGIN EXHAUSTIVE TABLE – START WRITING ALL ROWS HERE AND DO NOT STOP UNTIL EVERY USER BIOMARKER IS INCLUDED -->
+<!-- Example of the first row the model will continue from (delete this line and the example row in real output): -->
+| Hemoglobin                 | 14.8 g/dL      | Normal   | Optimal oxygen-carrying capacity.                                                         | 13–17 g/dL                       |
+<!-- NOW CONTINUE WITH THE REMAINING {{ total_count }} BIOMARKERS THE USER PROVIDED -->
+
+### Final Verification (you must include this exact text at the very end)
+I have included **exactly {{ exact_number_of_biomarkers_user_provided }} rows** in the Tabular Mapping section above.
+Every biomarker the user submitted appears exactly once. No biomarker was omitted.
 ------------------------------
 """