/* Global Styles */
* {
    margin: 0;
    padding: 0;
    box-sizing: border-box;
}

body {
    font-family: 'Segoe UI', Tahoma, Geneva, Verdana, sans-serif;
    line-height: 1.6;
    color: #333;
    background: linear-gradient(135deg, #667eea 0%, #764ba2 100%);
    min-height: 100vh;
}

.container {
    max-width: 1200px;
    margin: 0 auto;
    padding: 20px;
}

/* Header */
header {
    text-align: center;
    margin-bottom: 30px;
    color: white;
}

header h1 {
    font-size: 2.5em;
    margin-bottom: 10px;
    text-shadow: 2px 2px 4px rgba(0,0,0,0.3);
}

header p {
    font-size: 1.2em;
    opacity: 0.9;
}

/* Card Styles */
.card {
    background: white;
    border-radius: 15px;
    padding: 30px;
    margin-bottom: 20px;
    box-shadow: 0 10px 30px rgba(0,0,0,0.1);
    transition: transform 0.3s ease, box-shadow 0.3s ease;
}

.card:hover {
    transform: translateY(-5px);
    box-shadow: 0 15px 40px rgba(0,0,0,0.15);
}

.error-card {
    border-left: 5px solid #e74c3c;
    background: #fdf2f2;
}

/* Form Styles */
.form-group {
    margin-bottom: 20px;
}

.form-group label {
    display: block;
    margin-bottom: 8px;
    font-weight: 600;
    color: #555;
}

.form-group input,
.form-group select {
    width: 100%;
    padding: 12px;
    border: 2px solid #e1e8ed;
    border-radius: 8px;
    font-size: 16px;
    transition: border-color 0.3s ease, box-shadow 0.3s ease;
}

.form-group input:focus,
.form-group select:focus {
    outline: none;
    border-color: #667eea;
    box-shadow: 0 0 0 3px rgba(102, 126, 234, 0.1);
}

.radio-group {
    display: flex;
    gap: 20px;
}

.radio-group label {
    display: flex;
    align-items: center;
    margin-bottom: 0;
    cursor: pointer;
}

.radio-group input[type="radio"] {
    width: auto;
    margin-right: 8px;
}

.form-text {
    display: block;
    margin-top: 5px;
    font-size: 0.875em;
    color: #6c757d;
    font-style: italic;
}

/* Button Styles */
button {
    background: linear-gradient(135deg, #667eea 0%, #764ba2 100%);
    color: white;
    border: none;
    padding: 12px 24px;
    border-radius: 8px;
    font-size: 16px;
    font-weight: 600;
    cursor: pointer;
    transition: all 0.3s ease;
    text-transform: uppercase;
    letter-spacing: 0.5px;
}

button:hover {
    transform: translateY(-2px);
    box-shadow: 0 5px 15px rgba(102, 126, 234, 0.3);
}

button:active {
    transform: translateY(0);
}

button:disabled {
    opacity: 0.6;
    cursor: not-allowed;
}

#predictBtn {
    width: 100%;
    padding: 15px;
    font-size: 18px;
    margin-top: 20px;
}

.secondary-btn {
    background: linear-gradient(135deg, #6c757d 0%, #495057 100%);
    color: white;
    border: none;
    padding: 8px 16px;
    border-radius: 6px;
    font-size: 14px;
    font-weight: 500;
    cursor: pointer;
    transition: all 0.3s ease;
    text-transform: none;
    letter-spacing: normal;
    width: auto;
}

.secondary-btn:hover {
    transform: translateY(-1px);
    box-shadow: 0 3px 10px rgba(108, 117, 125, 0.3);
}

.secondary-btn:active {
    transform: translateY(0);
}

.secondary-btn.active {
    background: linear-gradient(135deg, #667eea 0%, #764ba2 100%);
}

.sphere-checkboxes {
    display: flex;
    flex-wrap: wrap;
    gap: 10px;
    margin-top: 5px;
}

.sphere-checkbox {
    display: flex;
    align-items: center;
    padding: 5px 10px;
    border: 1px solid #ddd;
    border-radius: 4px;
    background: #f8f9fa;
    font-size: 12px;
    cursor: pointer;
    transition: all 0.2s ease;
}

.sphere-checkbox:hover {
    background: #e9ecef;
    border-color: #667eea;
}

.sphere-checkbox input[type="checkbox"] {
    margin-right: 5px;
}

.sphere-checkbox.selected {
    background: #667eea;
    color: white;
    border-color: #667eea;
}

/* Progress Bar */
.progress-bar {
    width: 100%;
    height: 20px;
    background-color: #e1e8ed;
    border-radius: 10px;
    overflow: hidden;
    margin: 20px 0;
}

.progress-fill {
    height: 100%;
    background: linear-gradient(90deg, #667eea 0%, #764ba2 100%);
    border-radius: 10px;
    width: 0%;
    transition: width 0.3s ease;
}

/* Summary Grid */
.summary-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(200px, 1fr));
    gap: 15px;
    margin-top: 15px;
}

.summary-item {
    background: #f8f9fa;
    padding: 15px;
    border-radius: 8px;
    border-left: 4px solid #667eea;
}

.summary-item .label {
    display: block;
    font-weight: 600;
    color: #666;
    margin-bottom: 5px;
}

.summary-item .value {
    font-size: 1.5em;
    font-weight: bold;
    color: #333;
}

/* Visualization Controls */
.viz-controls {
    background: #f8f9fa;
    padding: 20px;
    border-radius: 8px;
    margin: 20px 0;
}

.control-group {
    display: flex;
    align-items: center;
    margin-bottom: 15px;
    gap: 15px;
}

.control-group label {
    min-width: 120px;
    margin-bottom: 0;
}

.control-group select,
.control-group input {
    flex: 1;
    max-width: 200px;
}

/* 3D Viewer */
.visualization-container {
    margin: 30px 0;
}

.viewer3d {
    width: 100%;
    height: 600px;
    border: 2px solid #e1e8ed;
    border-radius: 8px;
    background: #000;
    position: relative;
    overflow: hidden;
}

.viewer-controls {
    display: flex;
    gap: 10px;
    margin-top: 15px;
    justify-content: center;
}

.viewer-controls button {
    padding: 8px 16px;
    font-size: 14px;
}

/* Epitope List */
.epitope-list {
    margin: 30px 0;
}

#epitopeResidues {
    background: #f8f9fa;
    padding: 20px;
    border-radius: 8px;
    max-height: 300px;
    overflow-y: auto;
    line-height: 1.8;
}

.epitope-residue {
    display: inline-block;
    background: #667eea;
    color: white;
    padding: 5px 10px;
    margin: 2px;
    border-radius: 4px;
    font-family: 'Courier New', monospace;
    font-weight: bold;
}

/* Binding Region List */
.binding-region-list {
    margin: 30px 0;
}

#bindingRegionResidues {
    background: #f8f9fa;
    padding: 20px;
    border-radius: 8px;
    max-height: 300px;
    overflow-y: auto;
    line-height: 1.8;
}

.binding-region-residue {
    display: inline-block;
    background: #28a745;
    color: white;
    padding: 5px 10px;
    margin: 2px;
    border-radius: 4px;
    font-family: 'Courier New', monospace;
    font-weight: bold;
}

/* Download Section */
.download-section {
    margin-top: 30px;
    text-align: center;
}

.download-section button {
    margin: 0 10px;
    padding: 10px 20px;
}

/* Footer */
footer {
    text-align: center;
    margin-top: 50px;
    padding: 20px;
    color: white;
    opacity: 0.8;
}

/* Loading Spinner */
.loading {
    display: inline-block;
    width: 20px;
    height: 20px;
    border: 3px solid #f3f3f3;
    border-top: 3px solid #667eea;
    border-radius: 50%;
    animation: spin 1s linear infinite;
    margin-right: 10px;
}

@keyframes spin {
    0% { transform: rotate(0deg); }
    100% { transform: rotate(360deg); }
}

/* Responsive Design */
@media (max-width: 768px) {
    .container {
        padding: 10px;
    }
    
    header h1 {
        font-size: 2em;
    }
    
    .card {
        padding: 20px;
    }
    
    .summary-grid {
        grid-template-columns: 1fr;
    }
    
    .control-group {
        flex-direction: column;
        align-items: flex-start;
    }
    
    .control-group label {
        min-width: auto;
    }
    
    .control-group select,
    .control-group input {
        max-width: 100%;
    }
    
    .viewer3d {
        height: 400px;
    }
    
    .radio-group {
        flex-direction: column;
        gap: 10px;
    }
}

/* Animation Classes */
.fade-in {
    animation: fadeIn 0.5s ease-in;
}

@keyframes fadeIn {
    from { opacity: 0; transform: translateY(20px); }
    to { opacity: 1; transform: translateY(0); }
}

.slide-up {
    animation: slideUp 0.3s ease-out;
}

@keyframes slideUp {
    from { transform: translateY(20px); opacity: 0; }
    to { transform: translateY(0); opacity: 1; }
}

/* Color Legends */
.color-legend {
    display: flex;
    flex-wrap: wrap;
    gap: 15px;
    margin: 20px 0;
    padding: 15px;
    background: #f8f9fa;
    border-radius: 8px;
}

.legend-item {
    display: flex;
    align-items: center;
    gap: 8px;
}

.legend-color {
    width: 20px;
    height: 20px;
    border-radius: 4px;
    border: 1px solid #ddd;
}

.legend-label {
    font-size: 14px;
    color: #666;
}

/* Status Messages */
.status-message {
    padding: 12px 16px;
    border-radius: 6px;
    margin: 10px 0;
    font-weight: 500;
}

.status-success {
    background: #d4edda;
    color: #155724;
    border: 1px solid #c3e6cb;
}

.status-error {
    background: #f8d7da;
    color: #721c24;
    border: 1px solid #f5c6cb;
}

.status-warning {
    background: #fff3cd;
    color: #856404;
    border: 1px solid #ffeaa7;
}

.status-info {
    background: #cce7ff;
    color: #004085;
    border: 1px solid #bee5eb;
}

/* Tooltip */
.tooltip {
    position: relative;
    display: inline-block;
    cursor: help;
}

.tooltip .tooltiptext {
    visibility: hidden;
    width: 200px;
    background-color: #333;
    color: #fff;
    text-align: center;
    border-radius: 6px;
    padding: 5px 10px;
    position: absolute;
    z-index: 1000;
    bottom: 125%;
    left: 50%;
    margin-left: -100px;
    opacity: 0;
    transition: opacity 0.3s;
    font-size: 12px;
}

.tooltip:hover .tooltiptext {
    visibility: visible;
    opacity: 1;
}