Fix: Expand intervals to min 16384bp for AlphaGenome

app.py

@@ -82,12 +82,12 @@ else:
     # Initialize Client
     model = dna_client.create(api_key)
     
-    # Define dummy coordinates for the demo genes (simplified)
-    # in a real app, you'd look these up properly
+    # Define coordinates for demo genes - AlphaGenome needs minimum 16384bp sequences
+    # Using 20000bp intervals centered on each gene
     gene_coords = {
-        "INS": {"chr": "chr11", "start": 2159779, "end": 2161221, "pos": 2160000},
-        "SCN9A": {"chr": "chr2", "start": 166195190, "end": 166205190, "pos": 166200000}, # rounded
-        "MMP9": {"chr": "chr20", "start": 46010000, "end": 46020000, "pos": 46015000}
+        "INS": {"chr": "chr11", "start": 2150000, "end": 2170000, "pos": 2160000},
+        "SCN9A": {"chr": "chr2", "start": 166190000, "end": 166210000, "pos": 166200000},
+        "MMP9": {"chr": "chr20", "start": 46005000, "end": 46025000, "pos": 46015000}
     }
     
     gene_sym = gene_choice.split(' ')[0]