Fix: Use exact 16384bp length supported by AlphaGenome

app.py

@@ -82,12 +82,12 @@ else:
     # Initialize Client
     model = dna_client.create(api_key)
     
-    # Define coordinates for demo genes - AlphaGenome needs minimum 16384bp sequences
-    # Using 20000bp intervals centered on each gene
+    # Define coordinates for demo genes - AlphaGenome only supports specific lengths:
+    # 16384, 131072, 524288, 1048576 - using 16384bp intervals
     gene_coords = {
-        "INS": {"chr": "chr11", "start": 2150000, "end": 2170000, "pos": 2160000},
-        "SCN9A": {"chr": "chr2", "start": 166190000, "end": 166210000, "pos": 166200000},
-        "MMP9": {"chr": "chr20", "start": 46005000, "end": 46025000, "pos": 46015000}
+        "INS": {"chr": "chr11", "start": 2151808, "end": 2168192, "pos": 2160000},      # 16384bp
+        "SCN9A": {"chr": "chr2", "start": 166191808, "end": 166208192, "pos": 166200000},  # 16384bp
+        "MMP9": {"chr": "chr20", "start": 46006808, "end": 46023192, "pos": 46015000}   # 16384bp
     }
     
     gene_sym = gene_choice.split(' ')[0]