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app.py
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from transformers import pipeline
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import gradio as gr
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from flair.data import Sentence
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from flair.models import SequenceTagger
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import torch
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#constants
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GR_TXT1 = """
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Recent studies have identified several key mutations associated with familial breast cancer.
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The BRCA1 c.5266dupC mutation (p.Gln1756Profs74) was detected in 12% of patients, while the BRCA2 p.Ser1982fs variant showed reduced penetrance.
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Analysis revealed that the TP53 R175H substitution co-occurred with EGFR L858R in 8 cases.
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Additionally, the HER2 amplification correlated with response to trastuzumab therapy.
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Novel variants including PIK3CA E545K and AKT1 E17K were identified in endocrine-resistant tumors.
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The KRAS G12D mutation remained a negative predictive marker for anti-EGFR therapy.
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"""
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GR_TXT2 = """
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During the 12-week treatment period, 23 patients experienced adverse events.
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The most common was grade 2 nausea occurring in 15 participants, followed by fatigue in 11 cases.
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Three patients developed severe neutropenia requiring dose reduction, and two experienced thrombocytopenia.
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One case of drug-induced hepatotoxicity was documented with elevated ALT levels.
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Mild headache and dizziness were reported by 8 patients during the first week.
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Serious adverse events included one instance of anaphylaxis and two cases of Stevens-Johnson syndrome, leading to treatment discontinuation.
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No cardiovascular events or nephrotoxicity were observed.
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"""
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GR_MARKDOWN_TXT = """
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# 🧬 OTAR3088 Work-in-progress NER-models demo space
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This space allows for the **visualisation of outputs / review of our WIP NER-models.** Presently these models include... 👀:
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- **Adverse Events**
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- **Variants**
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👉 Try it out:
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1. Select a model from the dropdown menu.
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2. Enter/paste your text into the input box, or use our provided example biomedical paragraphs.
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3. View the extracted entities highlighted directly in **"Tagged Entities"** box.
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**Note📢:** Models in this demo are continuously updated and improved as part of our ongoing research.
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"""
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GR_THEME = gr.themes.Soft(
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primary_hue="indigo",
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secondary_hue="rose",
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neutral_hue="gray"
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)
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MODEL_REGISTRY = {
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"Variants-V1": "OTAR3088/Variants-V1",
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"AdverseEvent-PHEE-V1": "OTAR3088/hf-phee-V1"
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}
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hf_pipes = {}
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flair_pipes = {}
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def load_model(model_name):
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if model_name.lower().startswith("flair"):
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if not model_name in flair_pipes:
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# Force default tensor type
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torch.set_default_dtype(torch.float32)
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flair_pipes[model_name] = SequenceTagger.load(MODEL_REGISTRY[model_name])
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flair_pipes[model_name].to(torch.device("cpu"))
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flair_pipes[model_name].float()
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return flair_pipes[model_name], "flair"
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else:
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if not model_name in hf_pipes:
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hf_pipes[model_name] = pipeline("ner", model=MODEL_REGISTRY[model_name], aggregation_strategy='simple')
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return hf_pipes[model_name], "hf"
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def tagger(text, model_name):
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model, model_type = load_model(model_name)
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if model_type == "flair":
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sentence = Sentence(text)
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model.predict(sentence)
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entities = [{"start": ent.start_position,
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"end": ent.end_position,
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"score": ent.score,
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"entity": ent.tag} for ent in sentence.get_spans('ner')]
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elif model_type == "hf":
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entities = model(text)
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return {"text": text, "entities": entities}
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def gradio_ui():
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with gr.Blocks(theme=GR_THEME) as demo:
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with gr.Row():
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with gr.Column(scale=7):
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gr.Markdown(GR_MARKDOWN_TXT,elem_classes="full-width")
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input_text = gr.Textbox(label="Enter your text here", type='text', placeholder="Biomedical Input text", lines=8)
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gr.Examples(
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examples=[GR_TXT1, GR_TXT2],
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inputs=[input_text],
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label= "Example Biomedical texts to try (fabricated texts, not from literature)"
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)
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run_btn = gr.Button("Submit Text", variant="primary")
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with gr.Column(scale=7):
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model_choice = gr.Dropdown(choices=list(MODEL_REGISTRY.keys()), label="Select a model for Inference")
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output_highlight = gr.HighlightedText(label="Tagged Entities")
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# with gr.Row():
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# with gr.Column(scale=7):
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# input_text = gr.Textbox(label="Enter your text here", type='text', placeholder="Biomedical Input text", lines=8)
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# gr.Examples(
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# examples=[GR_TXT1, GR_TXT2],
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# inputs=[input_text],
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# label= "Example Biomedical texts to try"
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# )
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# run_btn = gr.Button("Submit Text", variant="primary")
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run_btn.click(
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fn=tagger,
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inputs=[input_text, model_choice],
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outputs=[output_highlight]
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)
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return demo
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if __name__ == "__main__":
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app = gradio_ui()
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app.launch()
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