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app.py
CHANGED
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import gradio as gr
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import os, requests, io
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import numpy as np
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from groq import Groq
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from PIL import Image
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@@ -28,103 +33,250 @@ textarea, input[type=number] { background: #f7fafc !important; color: #1a202c !i
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label span { color: #2b6cb0 !important; font-weight: 600 !important; font-size: 0.85em !important; text-transform: uppercase !important; }
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"""
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# Based on: orange-red color intensity maps to creatinine concentration
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creatinine = max(0, round(0.018 * orange_score - 0.3, 2))
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stage = "Normal"
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stage_color = "GREEN"
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action = "No CKD detected. Continue monitoring annually."
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elif creatinine < 1.5:
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stage = "Borderline"
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stage_color = "YELLOW"
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action = "Borderline range. Repeat test in 3 months. Consult physician."
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elif creatinine < 3.0:
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stage = "Stage 2 CKD"
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stage_color = "ORANGE"
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action = "Stage 2 CKD detected. Consult nephrologist. Confirm with Heska Element HT5."
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elif creatinine < 6.0:
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stage = "Stage 3-4 CKD"
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stage_color = "RED"
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action = "Advanced CKD. Immediate medical consultation required."
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else:
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stage = "Stage 5 CKD"
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stage_color = "CRITICAL"
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action = "Kidney failure range. Emergency medical care needed."
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result = (
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"uPAD PHOTO ANALYSIS RESULTS" + chr(10) +
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"βββββββββββββββββββββββββββ" + chr(10) +
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"DETECTION ZONE (center 30%):" + chr(10) +
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" R (Red): " + str(round(R, 1)) + chr(10) +
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" G (Green): " + str(round(G, 1)) + chr(10) +
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" B (Blue): " + str(round(B, 1)) + chr(10) +
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" Orange Score (R-B): " + str(round(orange_score, 1)) + chr(10) +
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"βββββββββββββββββββββββββββ" + chr(10) +
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"CREATININE: " + str(creatinine) + " mg/dL" + chr(10) +
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"CKD STAGE: " + stage + " [" + stage_color + "]" + chr(10) +
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"βββββββββββββββββββββββββββ" + chr(10) +
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"ACTION: " + action + chr(10) + chr(10) +
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"Normal range: 0.6-1.2 mg/dL" + chr(10) +
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"Confirm results with: Heska Element HT5" + chr(10) +
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"Method: Jaffe Reaction (picric acid)"
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)
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return
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except Exception as e:
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return None, "Error
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def analyze_upad_manual(r, g, b):
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c = max(0, round(0.02*(float(r)-float(b))-0.5, 2))
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if c < 1.2: s = "Normal - No CKD"
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elif c < 1.5: s = "Borderline - Monitor"
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elif c < 3.0: s = "Stage 2 CKD"
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elif c < 6.0: s = "Stage 3-4 CKD"
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else: s = "Stage 5 CKD - Kidney Failure"
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return ("uPAD MANUAL ANALYSIS" + chr(10) +
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"ββββββββββββββββββββ" + chr(10) +
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"RGB: R=" + str(r) + " G=" + str(g) + " B=" + str(b) + chr(10) +
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"Creatinine: " + str(c) + " mg/dL" + chr(10) +
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"CKD Stage: " + s + chr(10) +
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"Confirm with: Heska Element HT5")
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def get_pubmed(query, n=5):
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try:
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r = requests.get("https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi",
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history.append({"role":"assistant","content":"Voice error: "+str(e)})
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return history
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def
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if
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try:
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"
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"
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if r.status_code == 200:
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img = Image.open(io.BytesIO(r.content))
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return img, "Image generated!", description
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except: continue
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return None, "Models busy. Try again in 30 seconds.", description
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except Exception as e:
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return None, "Error: "+str(e)
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def piv_tool(velocity, shear, hr):
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v = "HIGH - stenosis
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s = "HIGH - thrombosis
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return ("PIV ANALYSIS RESULTS"+chr(10)+"ββββββββββββββββββββ"+chr(10)+
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"Velocity: "+str(velocity)+" m/s β "+v+chr(10)+
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"Shear: "+str(shear)+" Pa β "+s+chr(10)+
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"Heart Rate: "+str(hr)+" bpm β "+hr_s)
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def tgt_tool(tat,pf12,hemo,platelets,time):
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risk=sum([float(tat)>15,float(pf12)>2.0,float(hemo)>50,float(platelets)<150])
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r="HIGH
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return
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"Time: "+str(time)+" min"+chr(10)+
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"TAT: "+str(tat)+(" HIGH" if float(tat)>15 else " NORMAL")+chr(10)+
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"PF1.2: "+str(pf12)+(" HIGH" if float(pf12)>2.0 else " NORMAL")+chr(10)+
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"Hemo: "+str(hemo)+(" HIGH" if float(hemo)>50 else " NORMAL")+chr(10)+
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"Platelets: "+str(platelets)+(" LOW" if float(platelets)<150 else " NORMAL")+chr(10)+
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"ββββββββββββββββββββ"+chr(10)+"OVERALL: "+r)
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with gr.Blocks(title="CardioLab AI", css=CSS) as demo:
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gr.HTML('''<div style="background:linear-gradient(135deg,#1a237e,#b71c1c);padding:25px;text-align:center;border-radius:12px 12px 0 0"><div style="font-size:2.8em;font-weight:900;color:#fff;letter-spacing:3px">CardioLab AI</div></div>''')
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@@ -289,64 +454,84 @@ with gr.Blocks(title="CardioLab AI", css=CSS) as demo:
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search_btn.click(quick_search, inputs=search_input, outputs=search_output)
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search_input.submit(quick_search, inputs=search_input, outputs=search_output)
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with gr.Tab("uPAD Photo"):
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gr.Markdown("### Upload uPAD Photo β
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gr.Markdown("**How it works:** AI finds the detection zone in center of image, extracts RGB color from Jaffe reaction area, calculates creatinine level, gives CKD stage")
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gr.Markdown("**Supported:** Photo from phone camera, scanned image, or microscope image of uPAD test strip")
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with gr.Row():
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with gr.Column(scale=1):
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photo_input = gr.Image(label="Upload uPAD Photo", type="numpy", height=300)
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analyze_btn = gr.Button("Analyze uPAD Photo", variant="primary")
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gr.Markdown("**Tips for best results:**")
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gr.Markdown("- Take photo in good lighting")
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gr.Markdown("- Keep uPAD flat and centered")
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gr.Markdown("- Detection zone is center 30% of image")
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with gr.Column(scale=1):
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photo_result_img = gr.Image(label="Analyzed Image
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photo_result_text = gr.Textbox(label="CKD
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analyze_btn.click(analyze_upad_photo, inputs=photo_input, outputs=[photo_result_img, photo_result_text])
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with gr.Tab("uPAD Manual"):
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gr.Markdown("### Enter RGB values manually if you already measured them")
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with gr.Row():
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with gr.Column():
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r=gr.Number(label="R value", value=210
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g=gr.Number(label="G value", value=140
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b=gr.Number(label="B value", value=80
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out3=gr.Textbox(label="Result", lines=6)
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gr.Button("Analyze
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with gr.Tab("AI Image"):
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gr.Markdown("### Real AI Image Generation using FLUX.1")
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with gr.Row():
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img_prompt = gr.Textbox(placeholder="e.g. bileaflet
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with gr.Column(scale=1):
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img_btn = gr.Button("Generate
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img_status = gr.Textbox(label="Status", lines=2)
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img_desc = gr.Textbox(label="AI Description", lines=
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img_output = gr.Image(label="Generated Image", type="pil", height=
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img_btn.click(generate_image, inputs=img_prompt, outputs=[img_output, img_status, img_desc])
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with gr.Tab("PIV"):
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gr.Markdown("### Analyze PIV flow data from Mock Circulatory Loop")
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with gr.Row():
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with gr.Column():
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v=gr.Number(label="Max Velocity m/s", value=1.8
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s=gr.Number(label="Wall Shear Stress Pa", value=6.5
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h=gr.Number(label="Heart Rate bpm", value=72
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piv_out=gr.Textbox(label="Result", lines=
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gr.Button("Analyze PIV", variant="primary").click(piv_tool,inputs=[v,s,h],outputs=piv_out)
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with gr.Tab("TGT"):
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gr.Markdown("### Interpret Thrombogenicity Tester blood analysis results")
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with gr.Row():
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with gr.Column():
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t1=gr.Number(label="TAT ng/mL", value=18
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t2=gr.Number(label="PF1.2 nmol/L", value=2.5
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t3=gr.Number(label="Free Hemoglobin mg/L", value=60
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t4=gr.Number(label="Platelet Count", value=140
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t5=gr.Number(label="Time minutes", value=40)
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out2=gr.Textbox(label="Result", lines=
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gr.Button("Analyze TGT", variant="primary").click(tgt_tool,inputs=[t1,t2,t3,t4,t5],outputs=out2)
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demo.launch()
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import gradio as gr
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import os, requests, io
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import numpy as np
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import pandas as pd
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import matplotlib
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matplotlib.use("Agg")
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import matplotlib.pyplot as plt
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import matplotlib.patches as mpatches
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from groq import Groq
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from PIL import Image
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label span { color: #2b6cb0 !important; font-weight: 600 !important; font-size: 0.85em !important; text-transform: uppercase !important; }
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"""
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# βββ PIV CSV ANALYSIS ββββββββββββββββββββββββββββββββββββββββββββ
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def analyze_piv_csv(file):
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if file is None:
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return None, "Please upload a PIV CSV file."
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try:
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df = pd.read_csv(file.name)
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cols = [c.lower().strip() for c in df.columns]
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df.columns = cols
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| 45 |
+
fig, axes = plt.subplots(2, 2, figsize=(14, 10))
|
| 46 |
+
fig.patch.set_facecolor("#0d1b3e")
|
| 47 |
+
fig.suptitle("PIV Data Analysis β SJSU CardioLab MCL", color="white", fontsize=16, fontweight="bold", y=1.02)
|
| 48 |
+
|
| 49 |
+
colors = ["#e63946", "#4361ee", "#2ecc71", "#e67e22"]
|
| 50 |
+
|
| 51 |
+
# Plot 1 β Velocity over time or position
|
| 52 |
+
ax1 = axes[0, 0]
|
| 53 |
+
ax1.set_facecolor("#1a2744")
|
| 54 |
+
vel_col = next((c for c in cols if "vel" in c or "v_" in c or "u" == c or "speed" in c), cols[0] if len(cols)>0 else None)
|
| 55 |
+
x_col = next((c for c in cols if "time" in c or "x" in c or "pos" in c or "frame" in c), None)
|
| 56 |
+
if vel_col and x_col:
|
| 57 |
+
ax1.plot(df[x_col], df[vel_col], color="#e63946", linewidth=2, label=vel_col)
|
| 58 |
+
ax1.set_xlabel(x_col, color="#a8b2d8")
|
| 59 |
+
ax1.set_ylabel(vel_col, color="#a8b2d8")
|
| 60 |
+
elif vel_col:
|
| 61 |
+
ax1.plot(df[vel_col], color="#e63946", linewidth=2)
|
| 62 |
+
ax1.set_ylabel(vel_col, color="#a8b2d8")
|
| 63 |
+
else:
|
| 64 |
+
ax1.plot(df.iloc[:,0], color="#e63946", linewidth=2)
|
| 65 |
+
ax1.set_title("Velocity Profile", color="white", fontweight="bold")
|
| 66 |
+
ax1.tick_params(colors="#a8b2d8")
|
| 67 |
+
ax1.grid(True, alpha=0.2, color="#2d4a8a")
|
| 68 |
+
ax1.spines["bottom"].set_color("#2d4a8a")
|
| 69 |
+
ax1.spines["left"].set_color("#2d4a8a")
|
| 70 |
+
ax1.spines["top"].set_visible(False)
|
| 71 |
+
ax1.spines["right"].set_visible(False)
|
| 72 |
+
|
| 73 |
+
# Plot 2 β Shear stress if available
|
| 74 |
+
ax2 = axes[0, 1]
|
| 75 |
+
ax2.set_facecolor("#1a2744")
|
| 76 |
+
shear_col = next((c for c in cols if "shear" in c or "stress" in c or "tau" in c or "wss" in c), None)
|
| 77 |
+
if shear_col:
|
| 78 |
+
ax2.fill_between(range(len(df)), df[shear_col], alpha=0.7, color="#4361ee")
|
| 79 |
+
ax2.plot(df[shear_col], color="#4361ee", linewidth=2)
|
| 80 |
+
ax2.axhline(y=5, color="#e63946", linestyle="--", linewidth=1.5, label="Risk threshold (5 Pa)")
|
| 81 |
+
ax2.axhline(y=10, color="#ff4444", linestyle="--", linewidth=1.5, label="High risk (10 Pa)")
|
| 82 |
+
ax2.set_ylabel("Shear Stress (Pa)", color="#a8b2d8")
|
| 83 |
+
ax2.legend(fontsize=8, labelcolor="white", facecolor="#1a2744")
|
| 84 |
+
else:
|
| 85 |
+
# Plot second numeric column
|
| 86 |
+
num_cols = df.select_dtypes(include=[np.number]).columns.tolist()
|
| 87 |
+
if len(num_cols) >= 2:
|
| 88 |
+
ax2.fill_between(range(len(df)), df[num_cols[1]], alpha=0.7, color="#4361ee")
|
| 89 |
+
ax2.plot(df[num_cols[1]], color="#4361ee", linewidth=2)
|
| 90 |
+
ax2.set_ylabel(num_cols[1], color="#a8b2d8")
|
| 91 |
+
ax2.set_title("Shear Stress / Secondary Variable", color="white", fontweight="bold")
|
| 92 |
+
ax2.tick_params(colors="#a8b2d8")
|
| 93 |
+
ax2.grid(True, alpha=0.2, color="#2d4a8a")
|
| 94 |
+
ax2.spines["bottom"].set_color("#2d4a8a")
|
| 95 |
+
ax2.spines["left"].set_color("#2d4a8a")
|
| 96 |
+
ax2.spines["top"].set_visible(False)
|
| 97 |
+
ax2.spines["right"].set_visible(False)
|
| 98 |
+
|
| 99 |
+
# Plot 3 β Distribution histogram
|
| 100 |
+
ax3 = axes[1, 0]
|
| 101 |
+
ax3.set_facecolor("#1a2744")
|
| 102 |
+
num_cols = df.select_dtypes(include=[np.number]).columns.tolist()
|
| 103 |
+
if num_cols:
|
| 104 |
+
ax3.hist(df[num_cols[0]].dropna(), bins=30, color="#2ecc71", alpha=0.8, edgecolor="#1a2744")
|
| 105 |
+
ax3.set_xlabel(num_cols[0], color="#a8b2d8")
|
| 106 |
+
ax3.set_ylabel("Count", color="#a8b2d8")
|
| 107 |
+
ax3.set_title("Value Distribution", color="white", fontweight="bold")
|
| 108 |
+
ax3.tick_params(colors="#a8b2d8")
|
| 109 |
+
ax3.grid(True, alpha=0.2, color="#2d4a8a")
|
| 110 |
+
ax3.spines["bottom"].set_color("#2d4a8a")
|
| 111 |
+
ax3.spines["left"].set_color("#2d4a8a")
|
| 112 |
+
ax3.spines["top"].set_visible(False)
|
| 113 |
+
ax3.spines["right"].set_visible(False)
|
| 114 |
+
|
| 115 |
+
# Plot 4 β Summary stats
|
| 116 |
+
ax4 = axes[1, 1]
|
| 117 |
+
ax4.set_facecolor("#1a2744")
|
| 118 |
+
ax4.axis("off")
|
| 119 |
+
num_cols = df.select_dtypes(include=[np.number]).columns.tolist()
|
| 120 |
+
summary_text = "SUMMARY STATISTICS" + chr(10) + "β"*22 + chr(10)
|
| 121 |
+
risk_flags = []
|
| 122 |
+
for col in num_cols[:4]:
|
| 123 |
+
mean_val = df[col].mean()
|
| 124 |
+
max_val = df[col].max()
|
| 125 |
+
min_val = df[col].min()
|
| 126 |
+
summary_text += f"{col[:15]}:" + chr(10)
|
| 127 |
+
summary_text += f" Mean: {mean_val:.3f}" + chr(10)
|
| 128 |
+
summary_text += f" Max: {max_val:.3f}" + chr(10)
|
| 129 |
+
summary_text += f" Min: {min_val:.3f}" + chr(10)
|
| 130 |
+
if "vel" in col.lower() and max_val > 2.0:
|
| 131 |
+
risk_flags.append("HIGH VELOCITY - stenosis risk")
|
| 132 |
+
if "shear" in col.lower() and max_val > 10:
|
| 133 |
+
risk_flags.append("HIGH SHEAR - thrombosis risk")
|
| 134 |
+
if risk_flags:
|
| 135 |
+
summary_text += chr(10) + "RISK FLAGS:" + chr(10)
|
| 136 |
+
for flag in risk_flags:
|
| 137 |
+
summary_text += " β " + flag + chr(10)
|
| 138 |
+
ax4.text(0.05, 0.95, summary_text, transform=ax4.transAxes,
|
| 139 |
+
color="white", fontsize=9, verticalalignment="top",
|
| 140 |
+
fontfamily="monospace",
|
| 141 |
+
bbox=dict(boxstyle="round", facecolor="#0d1b3e", edgecolor="#4361ee", alpha=0.8))
|
| 142 |
+
|
| 143 |
+
plt.tight_layout()
|
| 144 |
+
buf = io.BytesIO()
|
| 145 |
+
plt.savefig(buf, format="png", facecolor=fig.get_facecolor(), bbox_inches="tight", dpi=120)
|
| 146 |
+
buf.seek(0)
|
| 147 |
+
img = Image.open(buf)
|
| 148 |
+
plt.close()
|
| 149 |
+
|
| 150 |
+
# AI analysis
|
| 151 |
+
ai_summary = ""
|
| 152 |
+
if GROQ_KEY:
|
| 153 |
+
try:
|
| 154 |
+
client = Groq(api_key=GROQ_KEY)
|
| 155 |
+
stats = df.describe().to_string()
|
| 156 |
+
msgs = [{"role":"system","content":"You are a PIV flow analysis expert for SJSU CardioLab. Analyze the statistics from the PIV CSV data and provide a clinical interpretation. Mention velocity ranges, shear stress levels, risk of stenosis or thrombosis, and recommendations."}]
|
| 157 |
+
msgs.append({"role":"user","content":"Analyze this PIV data from our Mock Circulatory Loop with 27mm SJM Regent MHV at 70bpm 5L/min:"+chr(10)+stats[:1000]})
|
| 158 |
+
resp = client.chat.completions.create(model="llama-3.3-70b-versatile",messages=msgs,max_tokens=400)
|
| 159 |
+
ai_summary = chr(10)+"β"*30+chr(10)+"AI CLINICAL INTERPRETATION:"+chr(10)+resp.choices[0].message.content
|
| 160 |
+
except: pass
|
| 161 |
|
| 162 |
+
result_text = ("PIV CSV ANALYSIS COMPLETE"+chr(10)+
|
| 163 |
+
"Rows: "+str(len(df))+" | Columns: "+str(len(df.columns))+chr(10)+
|
| 164 |
+
"Columns: "+", ".join(df.columns.tolist())+chr(10)+ai_summary)
|
| 165 |
|
| 166 |
+
return img, result_text
|
|
|
|
|
|
|
| 167 |
|
| 168 |
+
except Exception as e:
|
| 169 |
+
return None, "Error reading CSV: "+str(e)+chr(10)+"Make sure your CSV has headers and numeric data."
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 170 |
|
| 171 |
+
# βββ TGT CSV ANALYSIS ββββββββββββββββββββββββββββββββββββββββββββ
|
| 172 |
+
def analyze_tgt_csv(file):
|
| 173 |
+
if file is None:
|
| 174 |
+
return None, "Please upload a TGT CSV file."
|
| 175 |
+
try:
|
| 176 |
+
df = pd.read_csv(file.name)
|
| 177 |
+
cols = [c.lower().strip() for c in df.columns]
|
| 178 |
+
df.columns = cols
|
| 179 |
+
|
| 180 |
+
fig, axes = plt.subplots(2, 2, figsize=(14, 10))
|
| 181 |
+
fig.patch.set_facecolor("#0d1b3e")
|
| 182 |
+
fig.suptitle("TGT Blood Analysis β SJSU CardioLab", color="white", fontsize=16, fontweight="bold", y=1.02)
|
| 183 |
+
|
| 184 |
+
# Expected TGT columns: time, TAT, PF12, hemoglobin, platelets
|
| 185 |
+
time_col = next((c for c in cols if "time" in c or "min" in c), None)
|
| 186 |
+
tat_col = next((c for c in cols if "tat" in c or "thrombin" in c), None)
|
| 187 |
+
pf_col = next((c for c in cols if "pf" in c or "pf1" in c or "prothrombin" in c), None)
|
| 188 |
+
hemo_col = next((c for c in cols if "hemo" in c or "hemoglobin" in c or "hgb" in c), None)
|
| 189 |
+
plt_col = next((c for c in cols if "platelet" in c or "plt" in c), None)
|
| 190 |
+
|
| 191 |
+
num_cols = df.select_dtypes(include=[np.number]).columns.tolist()
|
| 192 |
+
x_axis = df[time_col] if time_col else range(len(df))
|
| 193 |
+
x_label = time_col if time_col else "Sample Number"
|
| 194 |
+
|
| 195 |
+
normal_limits = {"tat":8, "pf":2.0, "hemo":20, "platelet":150}
|
| 196 |
+
|
| 197 |
+
def style_ax(ax, title):
|
| 198 |
+
ax.set_facecolor("#1a2744")
|
| 199 |
+
ax.set_title(title, color="white", fontweight="bold")
|
| 200 |
+
ax.tick_params(colors="#a8b2d8")
|
| 201 |
+
ax.set_xlabel(x_label, color="#a8b2d8")
|
| 202 |
+
ax.grid(True, alpha=0.2, color="#2d4a8a")
|
| 203 |
+
ax.spines["bottom"].set_color("#2d4a8a")
|
| 204 |
+
ax.spines["left"].set_color("#2d4a8a")
|
| 205 |
+
ax.spines["top"].set_visible(False)
|
| 206 |
+
ax.spines["right"].set_visible(False)
|
| 207 |
+
|
| 208 |
+
# Plot 1 β TAT
|
| 209 |
+
ax1 = axes[0, 0]
|
| 210 |
+
col = tat_col if tat_col else (num_cols[0] if num_cols else None)
|
| 211 |
+
if col:
|
| 212 |
+
ax1.plot(x_axis, df[col], color="#e63946", linewidth=2.5, marker="o", markersize=6, label=col)
|
| 213 |
+
ax1.axhline(y=8, color="#ffd700", linestyle="--", linewidth=1.5, label="Normal limit (8 ng/mL)")
|
| 214 |
+
ax1.fill_between(x_axis, df[col], alpha=0.3, color="#e63946")
|
| 215 |
+
ax1.set_ylabel("TAT (ng/mL)", color="#a8b2d8")
|
| 216 |
+
ax1.legend(fontsize=8, labelcolor="white", facecolor="#1a2744")
|
| 217 |
+
style_ax(ax1, "Thrombin-Antithrombin (TAT)")
|
| 218 |
+
|
| 219 |
+
# Plot 2 β PF1.2
|
| 220 |
+
ax2 = axes[0, 1]
|
| 221 |
+
col2 = pf_col if pf_col else (num_cols[1] if len(num_cols)>1 else None)
|
| 222 |
+
if col2:
|
| 223 |
+
ax2.plot(x_axis, df[col2], color="#4361ee", linewidth=2.5, marker="s", markersize=6, label=col2)
|
| 224 |
+
ax2.axhline(y=2.0, color="#ffd700", linestyle="--", linewidth=1.5, label="Normal limit (2.0)")
|
| 225 |
+
ax2.fill_between(x_axis, df[col2], alpha=0.3, color="#4361ee")
|
| 226 |
+
ax2.set_ylabel("PF1.2 (nmol/L)", color="#a8b2d8")
|
| 227 |
+
ax2.legend(fontsize=8, labelcolor="white", facecolor="#1a2744")
|
| 228 |
+
style_ax(ax2, "Prothrombin Fragment (PF1.2)")
|
| 229 |
+
|
| 230 |
+
# Plot 3 β Hemoglobin / Hemolysis
|
| 231 |
+
ax3 = axes[1, 0]
|
| 232 |
+
col3 = hemo_col if hemo_col else (num_cols[2] if len(num_cols)>2 else None)
|
| 233 |
+
if col3:
|
| 234 |
+
ax3.bar(range(len(df)), df[col3], color="#2ecc71", alpha=0.8, edgecolor="#1a2744", label=col3)
|
| 235 |
+
ax3.axhline(y=20, color="#ffd700", linestyle="--", linewidth=1.5, label="Normal limit (20 mg/L)")
|
| 236 |
+
ax3.set_ylabel("Free Hemoglobin (mg/L)", color="#a8b2d8")
|
| 237 |
+
ax3.legend(fontsize=8, labelcolor="white", facecolor="#1a2744")
|
| 238 |
+
style_ax(ax3, "Free Hemoglobin (Hemolysis)")
|
| 239 |
+
|
| 240 |
+
# Plot 4 β Platelets
|
| 241 |
+
ax4 = axes[1, 1]
|
| 242 |
+
col4 = plt_col if plt_col else (num_cols[3] if len(num_cols)>3 else None)
|
| 243 |
+
if col4:
|
| 244 |
+
ax4.plot(x_axis, df[col4], color="#e67e22", linewidth=2.5, marker="^", markersize=6, label=col4)
|
| 245 |
+
ax4.axhline(y=150, color="#ffd700", linestyle="--", linewidth=1.5, label="Normal minimum (150)")
|
| 246 |
+
ax4.fill_between(x_axis, df[col4], 150, where=df[col4]<150, alpha=0.3, color="#e63946", label="Below normal")
|
| 247 |
+
ax4.set_ylabel("Platelet Count (10Β³/ΞΌL)", color="#a8b2d8")
|
| 248 |
+
ax4.legend(fontsize=8, labelcolor="white", facecolor="#1a2744")
|
| 249 |
+
style_ax(ax4, "Platelet Count")
|
| 250 |
+
|
| 251 |
+
plt.tight_layout()
|
| 252 |
+
buf = io.BytesIO()
|
| 253 |
+
plt.savefig(buf, format="png", facecolor=fig.get_facecolor(), bbox_inches="tight", dpi=120)
|
| 254 |
+
buf.seek(0)
|
| 255 |
+
img = Image.open(buf)
|
| 256 |
+
plt.close()
|
| 257 |
+
|
| 258 |
+
# AI analysis
|
| 259 |
+
ai_summary = ""
|
| 260 |
+
if GROQ_KEY:
|
| 261 |
+
try:
|
| 262 |
+
client = Groq(api_key=GROQ_KEY)
|
| 263 |
+
stats = df.describe().to_string()
|
| 264 |
+
msgs = [{"role":"system","content":"You are a hematology expert for SJSU CardioLab TGT testing. Analyze the blood biomarker data and provide thrombogenicity assessment. Comment on TAT levels, PF1.2, hemolysis, platelet consumption. Give overall thrombogenic risk: LOW MODERATE or HIGH. Reference normal ranges: TAT below 8 ng/mL, PF1.2 below 2.0 nmol/L, Hemoglobin below 20 mg/L, Platelets above 150."}]
|
| 265 |
+
msgs.append({"role":"user","content":"Analyze TGT blood data from 27mm SJM Regent MHV tested in our MCL at 70bpm 5L/min:"+chr(10)+stats[:1000]})
|
| 266 |
+
resp = client.chat.completions.create(model="llama-3.3-70b-versatile",messages=msgs,max_tokens=400)
|
| 267 |
+
ai_summary = chr(10)+"β"*30+chr(10)+"AI THROMBOGENICITY ASSESSMENT:"+chr(10)+resp.choices[0].message.content
|
| 268 |
+
except: pass
|
| 269 |
|
| 270 |
+
result_text = ("TGT CSV ANALYSIS COMPLETE"+chr(10)+
|
| 271 |
+
"Rows: "+str(len(df))+" | Columns: "+str(len(df.columns))+chr(10)+
|
| 272 |
+
"Columns detected: "+", ".join(df.columns.tolist())+chr(10)+ai_summary)
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 273 |
|
| 274 |
+
return img, result_text
|
| 275 |
|
| 276 |
except Exception as e:
|
| 277 |
+
return None, "Error reading CSV: "+str(e)+chr(10)+"Make sure your CSV has headers like: time, TAT, PF12, hemoglobin, platelets"
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 278 |
|
| 279 |
+
# βββ OTHER FUNCTIONS ββββββββββββββββββββββββββββββββββββββββββββββ
|
| 280 |
def get_pubmed(query, n=5):
|
| 281 |
try:
|
| 282 |
r = requests.get("https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi",
|
|
|
|
| 348 |
history.append({"role":"assistant","content":"Voice error: "+str(e)})
|
| 349 |
return history
|
| 350 |
|
| 351 |
+
def analyze_upad_photo(image):
|
| 352 |
+
if image is None:
|
| 353 |
+
return None, "Please upload a uPAD photo first."
|
| 354 |
try:
|
| 355 |
+
img = Image.fromarray(image) if not isinstance(image, Image.Image) else image
|
| 356 |
+
img_array = np.array(img)
|
| 357 |
+
h, w = img_array.shape[:2]
|
| 358 |
+
y1,y2 = int(h*0.35),int(h*0.65)
|
| 359 |
+
x1,x2 = int(w*0.35),int(w*0.65)
|
| 360 |
+
zone = img_array[y1:y2, x1:x2]
|
| 361 |
+
R = float(np.mean(zone[:,:,0]))
|
| 362 |
+
G = float(np.mean(zone[:,:,1]))
|
| 363 |
+
B = float(np.mean(zone[:,:,2]))
|
| 364 |
+
orange_score = R - B
|
| 365 |
+
creatinine = max(0, round(0.018 * orange_score - 0.3, 2))
|
| 366 |
+
if creatinine < 1.2: stage,action = "Normal","No CKD. Monitor annually."
|
| 367 |
+
elif creatinine < 1.5: stage,action = "Borderline","Repeat in 3 months. Consult physician."
|
| 368 |
+
elif creatinine < 3.0: stage,action = "Stage 2 CKD","Consult nephrologist. Confirm with Heska HT5."
|
| 369 |
+
elif creatinine < 6.0: stage,action = "Stage 3-4 CKD","Advanced CKD. Immediate medical consultation."
|
| 370 |
+
else: stage,action = "Stage 5 CKD","Kidney failure range. Emergency care needed."
|
| 371 |
+
result_img = img.copy()
|
| 372 |
+
import PIL.ImageDraw as ImageDraw
|
| 373 |
+
draw = ImageDraw.Draw(result_img)
|
| 374 |
+
draw.rectangle([x1,y1,x2,y2], outline=(0,255,0), width=3)
|
| 375 |
+
result = ("uPAD PHOTO ANALYSIS"+chr(10)+"β"*27+chr(10)+
|
| 376 |
+
"R: "+str(round(R,1))+" G: "+str(round(G,1))+" B: "+str(round(B,1))+chr(10)+
|
| 377 |
+
"Orange Score: "+str(round(orange_score,1))+chr(10)+"β"*27+chr(10)+
|
| 378 |
+
"CREATININE: "+str(creatinine)+" mg/dL"+chr(10)+
|
| 379 |
+
"CKD STAGE: "+stage+chr(10)+"β"*27+chr(10)+
|
| 380 |
+
"ACTION: "+action+chr(10)+"Confirm with: Heska Element HT5")
|
| 381 |
+
return result_img, result
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 382 |
except Exception as e:
|
| 383 |
+
return None, "Error: "+str(e)
|
| 384 |
|
| 385 |
def piv_tool(velocity, shear, hr):
|
| 386 |
+
v = "HIGH - stenosis" if float(velocity)>2.0 else "NORMAL"
|
| 387 |
+
s = "HIGH - thrombosis" if float(shear)>10 else "ELEVATED" if float(shear)>5 else "NORMAL"
|
| 388 |
+
return "PIV: Velocity "+str(velocity)+" m/s - "+v+chr(10)+"Shear "+str(shear)+" Pa - "+s+chr(10)+"HR "+str(hr)+" bpm"
|
|
|
|
|
|
|
|
|
|
|
|
|
| 389 |
|
| 390 |
def tgt_tool(tat,pf12,hemo,platelets,time):
|
| 391 |
risk=sum([float(tat)>15,float(pf12)>2.0,float(hemo)>50,float(platelets)<150])
|
| 392 |
+
r="HIGH RISK" if risk>=3 else "MODERATE" if risk>=2 else "LOW RISK"
|
| 393 |
+
return "TGT: TAT "+str(tat)+" PF1.2 "+str(pf12)+chr(10)+"Hemo "+str(hemo)+" Plt "+str(platelets)+chr(10)+"Time "+str(time)+" min"+chr(10)+"RESULT: "+r
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 394 |
|
| 395 |
+
def generate_image(prompt):
|
| 396 |
+
if not prompt.strip(): return None,"Enter description.","";
|
| 397 |
+
if not HF_TOKEN: return None,"Error: Add HF_TOKEN to Space secrets.","";
|
| 398 |
+
try:
|
| 399 |
+
enhanced=prompt
|
| 400 |
+
description=""
|
| 401 |
+
if GROQ_KEY:
|
| 402 |
+
try:
|
| 403 |
+
client=Groq(api_key=GROQ_KEY)
|
| 404 |
+
msgs=[{"role":"system","content":"Biomedical visualization expert. Format: DESCRIPTION: [desc] PROMPT: [prompt]"},{"role":"user","content":"Create image for: "+prompt}]
|
| 405 |
+
resp=client.chat.completions.create(model="llama-3.3-70b-versatile",messages=msgs,max_tokens=200)
|
| 406 |
+
full=resp.choices[0].message.content
|
| 407 |
+
if "DESCRIPTION:" in full and "PROMPT:" in full:
|
| 408 |
+
description=full.split("DESCRIPTION:")[1].split("PROMPT:")[0].strip()
|
| 409 |
+
enhanced=full.split("PROMPT:")[1].strip()
|
| 410 |
+
except: pass
|
| 411 |
+
headers={"Authorization":"Bearer "+HF_TOKEN,"Content-Type":"application/json"}
|
| 412 |
+
payload={"inputs":enhanced,"parameters":{"num_inference_steps":8}}
|
| 413 |
+
for url in ["https://router.huggingface.co/hf-inference/models/black-forest-labs/FLUX.1-schnell","https://router.huggingface.co/hf-inference/models/stabilityai/stable-diffusion-xl-base-1.0"]:
|
| 414 |
+
try:
|
| 415 |
+
r=requests.post(url,headers=headers,json=payload,timeout=60)
|
| 416 |
+
if r.status_code==200:
|
| 417 |
+
return Image.open(io.BytesIO(r.content)),"Generated!",description
|
| 418 |
+
except: continue
|
| 419 |
+
return None,"Models busy. Try again.",description
|
| 420 |
+
except Exception as e: return None,"Error: "+str(e),""
|
| 421 |
+
|
| 422 |
+
# βββ UI βββββββββββββββββββββββββββββββββββββββββββββββββββββββββββ
|
| 423 |
with gr.Blocks(title="CardioLab AI", css=CSS) as demo:
|
| 424 |
gr.HTML('''<div style="background:linear-gradient(135deg,#1a237e,#b71c1c);padding:25px;text-align:center;border-radius:12px 12px 0 0"><div style="font-size:2.8em;font-weight:900;color:#fff;letter-spacing:3px">CardioLab AI</div></div>''')
|
| 425 |
|
|
|
|
| 454 |
search_btn.click(quick_search, inputs=search_input, outputs=search_output)
|
| 455 |
search_input.submit(quick_search, inputs=search_input, outputs=search_output)
|
| 456 |
|
| 457 |
+
with gr.Tab("PIV Data"):
|
| 458 |
+
gr.Markdown("### Upload PIV CSV β AI generates charts and clinical interpretation")
|
| 459 |
+
gr.Markdown("**Expected columns:** time/x, velocity, shear_stress (any names work β AI detects automatically)")
|
| 460 |
+
with gr.Row():
|
| 461 |
+
with gr.Column(scale=1):
|
| 462 |
+
piv_file = gr.File(label="Upload PIV CSV File", file_types=[".csv"])
|
| 463 |
+
piv_analyze_btn = gr.Button("Analyze PIV Data", variant="primary")
|
| 464 |
+
gr.Markdown("**Sample CSV format:**")
|
| 465 |
+
gr.Markdown("```\ntime,velocity,shear_stress\n0,0.5,2.1\n1,1.2,4.5\n2,1.8,7.2\n```")
|
| 466 |
+
with gr.Column(scale=2):
|
| 467 |
+
piv_chart = gr.Image(label="PIV Charts", type="pil", height=450)
|
| 468 |
+
piv_ai_result = gr.Textbox(label="AI Clinical Analysis", lines=10)
|
| 469 |
+
piv_analyze_btn.click(analyze_piv_csv, inputs=piv_file, outputs=[piv_chart, piv_ai_result])
|
| 470 |
+
|
| 471 |
+
with gr.Tab("TGT Data"):
|
| 472 |
+
gr.Markdown("### Upload TGT CSV β AI generates blood biomarker charts and thrombogenicity assessment")
|
| 473 |
+
gr.Markdown("**Expected columns:** time, TAT, PF12, hemoglobin, platelets (any names work β AI detects automatically)")
|
| 474 |
+
with gr.Row():
|
| 475 |
+
with gr.Column(scale=1):
|
| 476 |
+
tgt_file = gr.File(label="Upload TGT CSV File", file_types=[".csv"])
|
| 477 |
+
tgt_analyze_btn = gr.Button("Analyze TGT Data", variant="primary")
|
| 478 |
+
gr.Markdown("**Sample CSV format:**")
|
| 479 |
+
gr.Markdown("```\ntime,TAT,PF12,hemoglobin,platelets\n0,5.2,1.1,12,210\n20,9.8,1.8,18,195\n40,14.2,2.4,35,178\n60,18.6,3.1,62,145\n```")
|
| 480 |
+
with gr.Column(scale=2):
|
| 481 |
+
tgt_chart = gr.Image(label="TGT Blood Analysis Charts", type="pil", height=450)
|
| 482 |
+
tgt_ai_result = gr.Textbox(label="AI Thrombogenicity Assessment", lines=10)
|
| 483 |
+
tgt_analyze_btn.click(analyze_tgt_csv, inputs=tgt_file, outputs=[tgt_chart, tgt_ai_result])
|
| 484 |
+
|
| 485 |
with gr.Tab("uPAD Photo"):
|
| 486 |
+
gr.Markdown("### Upload uPAD Photo β Instant CKD diagnosis from Jaffe reaction color")
|
|
|
|
|
|
|
| 487 |
with gr.Row():
|
| 488 |
with gr.Column(scale=1):
|
| 489 |
photo_input = gr.Image(label="Upload uPAD Photo", type="numpy", height=300)
|
| 490 |
analyze_btn = gr.Button("Analyze uPAD Photo", variant="primary")
|
|
|
|
|
|
|
|
|
|
|
|
|
| 491 |
with gr.Column(scale=1):
|
| 492 |
+
photo_result_img = gr.Image(label="Analyzed Image", type="pil", height=300)
|
| 493 |
+
photo_result_text = gr.Textbox(label="CKD Result", lines=12)
|
| 494 |
analyze_btn.click(analyze_upad_photo, inputs=photo_input, outputs=[photo_result_img, photo_result_text])
|
| 495 |
|
| 496 |
with gr.Tab("uPAD Manual"):
|
|
|
|
| 497 |
with gr.Row():
|
| 498 |
with gr.Column():
|
| 499 |
+
r=gr.Number(label="R value", value=210)
|
| 500 |
+
g=gr.Number(label="G value", value=140)
|
| 501 |
+
b=gr.Number(label="B value", value=80)
|
| 502 |
out3=gr.Textbox(label="Result", lines=6)
|
| 503 |
+
gr.Button("Analyze", variant="primary").click(
|
| 504 |
+
lambda r,g,b: "Creatinine: "+str(max(0,round(0.02*(r-b)-0.5,2)))+" mg/dL"+chr(10)+("Normal" if max(0,round(0.02*(r-b)-0.5,2))<1.2 else "Borderline" if max(0,round(0.02*(r-b)-0.5,2))<1.5 else "CKD"),
|
| 505 |
+
inputs=[r,g,b], outputs=out3)
|
| 506 |
|
| 507 |
with gr.Tab("AI Image"):
|
|
|
|
| 508 |
with gr.Row():
|
| 509 |
+
img_prompt = gr.Textbox(placeholder="e.g. bileaflet heart valve | uPAD microfluidic | Arduino TGT circuit", label="Describe image", lines=3, scale=4)
|
| 510 |
with gr.Column(scale=1):
|
| 511 |
+
img_btn = gr.Button("Generate", variant="primary")
|
| 512 |
img_status = gr.Textbox(label="Status", lines=2)
|
| 513 |
+
img_desc = gr.Textbox(label="AI Description", lines=2, interactive=False)
|
| 514 |
+
img_output = gr.Image(label="Generated Image", type="pil", height=400)
|
| 515 |
img_btn.click(generate_image, inputs=img_prompt, outputs=[img_output, img_status, img_desc])
|
| 516 |
|
| 517 |
+
with gr.Tab("PIV Manual"):
|
|
|
|
| 518 |
with gr.Row():
|
| 519 |
with gr.Column():
|
| 520 |
+
v=gr.Number(label="Max Velocity m/s", value=1.8)
|
| 521 |
+
s=gr.Number(label="Wall Shear Stress Pa", value=6.5)
|
| 522 |
+
h=gr.Number(label="Heart Rate bpm", value=72)
|
| 523 |
+
piv_out=gr.Textbox(label="Result", lines=5)
|
| 524 |
gr.Button("Analyze PIV", variant="primary").click(piv_tool,inputs=[v,s,h],outputs=piv_out)
|
| 525 |
|
| 526 |
+
with gr.Tab("TGT Manual"):
|
|
|
|
| 527 |
with gr.Row():
|
| 528 |
with gr.Column():
|
| 529 |
+
t1=gr.Number(label="TAT ng/mL", value=18)
|
| 530 |
+
t2=gr.Number(label="PF1.2 nmol/L", value=2.5)
|
| 531 |
+
t3=gr.Number(label="Free Hemoglobin mg/L", value=60)
|
| 532 |
+
t4=gr.Number(label="Platelet Count", value=140)
|
| 533 |
t5=gr.Number(label="Time minutes", value=40)
|
| 534 |
+
out2=gr.Textbox(label="Result", lines=8)
|
| 535 |
gr.Button("Analyze TGT", variant="primary").click(tgt_tool,inputs=[t1,t2,t3,t4,t5],outputs=out2)
|
| 536 |
|
| 537 |
demo.launch()
|