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analytics/feedback.csv
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timestamp_utc,session_id,first_name,last_name,question,answer,rating,comment
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2025-09-15T01:
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timestamp_utc,session_id,first_name,last_name,question,answer,rating,comment
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2025-09-15T01:57:03.517513+00:00,50f50ee0-0bcb-4c1a-b1f8-3f9ed70da18c,Shubh,Laiwala,Mechanism of thyroxine hornone,"[LLM fallback — ungrounded]
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Thyroid hormones play a crucial role in the development and maintenance of musculosketal systems, including bone metabolism. Thyroxin (T4) and triiodothyronine (T3) bind to thyroid hormone receptors (TRs) in osteoblasts, stimulating the expression of genes involved in bone formation and resorption, thereby promoting bone growth and remodeling. The thyroid gland secretes T4 and T3, which are transported to target tissues by thyroid-binding globulin (TBG), thyroid binding prealbumin (transthyretin), and albumin. In bone, thyroid receptores are expressed in ossification cells, chondrocytes, and osteoclasts. Thryoid hormones increase osteogenic differentiation of mesenchymal stem cells, enhance osteoprogenitor cell proliferation, and promote osteocalcin expression. They also inhibit osteo-clastogenesis and increase bone turnover. In addition, thyroids regulate the expression and activity of other growth factors, such as IGF-1 and BMPs, and",2,
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