{ "delta_value": [ "0-1", "1-0", "0-0", "(-inf, -10.5]", "(-10.5, -8.5]","(-8.5, -6.5]","(-6.5, -4.5]","(-4.5, -2.5]","(-2.5, -1.5]","(-1.5, -1.0]","(-1.0, -0.5]","(-0.5, 0.0]","(0.0, 0.5]","(0.5, 1.0]","(1.0, 1.5]","(1.5, 2.5]","(2.5, 4.5]","(4.5, 6.5]","(6.5, 8.5]","(8.5, 10.5]","(10.5, inf]" ], "activity": [ "IC50 (nM)", "Kd (nM)", "EC50 (nM)", "Ki (nM)" ], "toxicity": [ "toxcast-NVS_TR_rVMAT2", "toxcast-BSK_4H_SRB_down", "toxcast-Tanguay_ZF_120hpf_CFIN_up", "toxcast-OT_FXR_FXRSRC1_1440", "toxcast-ATG_GRE_CIS_up", "toxcast-TOX21_Aromatase_Inhibition", "toxcast-ATG_NRF2_ARE_CIS_dn", "toxcast-Tanguay_ZF_120hpf_PFIN_up", "toxcast-NVS_LGIC_h5HT3", "toxcast-APR_HepG2_NuclearSize_72h_dn", "toxcast-ATG_Sox_CIS_up", "toxcast-OT_NURR1_NURR1RXRa_0480", "toxcast-ATG_VDRE_CIS_up", "toxcast-OT_ER_ERaERa_1440", "toxcast-NVS_GPCR_hAdrb3", "toxcast-TOX21_NFkB_BLA_agonist_ch2", "toxcast-NCCT_QuantiLum_inhib_2_dn", "toxcast-Tanguay_ZF_120hpf_MORT_up", "toxcast-APR_HepG2_p53Act_72h_up", "toxcast-BSK_3C_VCAM1_down", "toxcast-ATG_RARg_TRANS_dn", "toxcast-ATG_ERRa_TRANS_dn", "toxcast-Tanguay_ZF_120hpf_TRUN_up", "toxcast-TOX21_PPARg_BLA_antagonist_viability", "toxcast-NVS_GPCR_rmAdra2B", "toxcast-NVS_GPCR_hAdoRA2a", "toxcast-TOX21_PPARd_BLA_antagonist_viability", "toxcast-BSK_hDFCGF_MIG_down", "toxcast-TOX21_HSE_BLA_agonist_ch2", "tox21-NR-AR-LBD", "toxcast-APR_HepG2_MitoticArrest_72h_up", "toxcast-ATG_RORE_CIS_dn", "toxcast-NVS_GPCR_hDRD4.4", "toxcast-NVS_GPCR_h5HT7", "toxcast-TOX21_VDR_BLA_agonist_ch2", "toxcast-BSK_LPS_TNFa_up", "toxcast-ATG_VDR_TRANS_up", "toxcast-BSK_CASM3C_SRB_down", "toxcast-Tanguay_ZF_120hpf_EYE_up", "toxcast-BSK_LPS_IL8_up", "toxcast-CLD_UGT1A1_48hr", "toxcast-TOX21_p53_BLA_p3_ch2", "toxcast-ATG_EGR_CIS_up", "toxcast-ATG_SREBP_CIS_up", "toxcast-TOX21_ERa_BLA_Antagonist_ch2", "toxcast-ATG_MRE_CIS_up", "toxcast-ATG_HNF6_CIS_dn", "toxcast-TOX21_p53_BLA_p2_ratio", "toxcast-BSK_SAg_MIG_down", "toxcast-ATG_NURR1_TRANS_dn", "toxcast-Tanguay_ZF_120hpf_PIG_up", "toxcast-NVS_ADME_hCYP19A1", "toxcast-APR_HepG2_OxidativeStress_72h_up", "toxcast-NVS_GPCR_rSST", "toxcast-APR_HepG2_MicrotubuleCSK_72h_up", "toxcast-NVS_NR_hER", "tox21-NR-ER-LBD", "toxcast-NVS_MP_rPBR", "toxcast-TOX21_p53_BLA_p5_ch2", "toxcast-TOX21_AR_BLA_Antagonist_ratio", "toxcast-TOX21_ARE_BLA_agonist_ratio", "toxcast-ATG_E_Box_CIS_dn", "toxcast-NVS_IC_hKhERGCh", "toxcast-ATG_M_06_TRANS_up", "toxcast-ATG_Xbp1_CIS_dn", "toxcast-ATG_HIF1a_CIS_dn", "toxcast-BSK_3C_TissueFactor_down", "toxcast-TOX21_p53_BLA_p5_viability", "toxcast-TOX21_NFkB_BLA_agonist_ratio", "toxcast-CEETOX_H295R_OHPROG_dn", "toxcast-NVS_GPCR_rOpiate_NonSelectiveNa", "toxcast-BSK_3C_Vis_down", "toxcast-BSK_3C_Thrombomodulin_down", "skin_reaction", "toxcast-TOX21_AR_BLA_Antagonist_ch1", "toxcast-TOX21_NFkB_BLA_agonist_viability", "toxcast-NVS_ENZ_hElastase", "toxcast-NVS_GPCR_r5HT1_NonSelective", "toxcast-ATG_RXRa_TRANS_dn", "toxcast-APR_Hepat_MitoFxnI_24hr_dn", "toxcast-NVS_MP_hPBR", "toxcast-ATG_FXR_TRANS_up", "toxcast-BSK_CASM3C_SAA_up", "toxcast-BSK_CASM3C_HLADR_down", "toxcast-APR_HepG2_CellLoss_72h_dn", "toxcast-ATG_HIF1a_CIS_up", "toxcast-TOX21_MMP_viability", "toxcast-BSK_CASM3C_MIG_down", "toxcast-ATG_RARb_TRANS_dn", "toxcast-NCCT_HEK293T_CellTiterGLO", "toxcast-NVS_GPCR_g5HT4", "toxcast-TOX21_ERa_BLA_Agonist_ch2", "toxcast-TOX21_PPARg_BLA_Agonist_ch1", "toxcast-ATG_RORE_CIS_up", "toxcast-NVS_ENZ_oCOX2", "toxcast-NVS_NR_mERa", "toxcast-BSK_hDFCGF_PAI1_down", "toxcast-APR_HepG2_MicrotubuleCSK_72h_dn", "toxcast-ATG_E2F_CIS_dn", "toxcast-BSK_LPS_IL1a_up", "toxcast-ATG_RARa_TRANS_up", "toxcast-CLD_CYP1A2_24hr", "toxcast-ATG_GAL4_TRANS_dn", "toxcast-BSK_KF3CT_IP10_down", "toxcast-NVS_GPCR_hOpiate_D1", "toxcast-NVS_GPCR_rAdra2_NonSelective", "toxcast-ATG_RXRa_TRANS_up", "toxcast-CLD_GSTA2_48hr", "toxcast-ATG_HNF4a_TRANS_up", "toxcast-APR_HepG2_StressKinase_1h_up", "toxcast-BSK_KF3CT_uPA_down", "toxcast-TOX21_GR_BLA_Antagonist_viability", "toxcast-NVS_ENZ_hGSK3b", "toxcast-NVS_NR_rMR", "toxcast-CEETOX_H295R_PROG_up", "toxcast-ATG_PPARg_TRANS_up", "toxcast-BSK_KF3CT_MCP1_down", "toxcast-TOX21_HSE_BLA_agonist_viability", "toxcast-CLD_CYP1A1_6hr", "toxcast-NVS_GPCR_rAdrb_NonSelective", "toxcast-NVS_ADME_hCYP2C9", "toxcast-NVS_ADME_hCYP2A6", "toxcast-TOX21_VDR_BLA_antagonist_viability", "toxcast-OT_FXR_FXRSRC1_0480", "toxcast-BSK_3C_ICAM1_down", "toxcast-TOX21_PPARd_BLA_agonist_ratio", "toxcast-NVS_ENZ_hPTPN11", "toxcast-APR_HepG2_p53Act_24h_up", "toxcast-ATG_TA_CIS_up", "toxcast-ATG_THRa1_TRANS_dn", "toxcast-APR_Hepat_DNADamage_24hr_up", "toxcast-APR_HepG2_MitoticArrest_24h_up", "toxcast-BSK_KF3CT_TGFb1_down", "toxcast-TOX21_PPARg_BLA_Agonist_ch2", "toxcast-CLD_CYP1A1_48hr", "toxcast-ATG_THRa1_TRANS_up", "toxcast-TOX21_p53_BLA_p1_ratio", "toxcast-APR_Hepat_MitoFxnI_1hr_dn", "herg_central-hERG_at_1uM", "toxcast-APR_HepG2_CellCycleArrest_24h_dn", "toxcast-NVS_GPCR_hAdoRA1", "toxcast-TOX21_ERa_BLA_Agonist_ratio", "toxcast-OT_ER_ERbERb_0480", "toxcast-TOX21_AR_LUC_MDAKB2_Agonist", "toxcast-TOX21_GR_BLA_Antagonist_ratio", "toxcast-NVS_GPCR_hDRD2s", "toxcast-NVS_LGIC_rNNR_BungSens", "toxcast-BSK_KF3CT_SRB_down", "toxcast-NVS_GPCR_hDRD1", "toxcast-NVS_ENZ_hPTPN12", "toxcast-NVS_GPCR_hNK2", "toxcast-APR_HepG2_OxidativeStress_24h_up", "toxcast-ATG_M_32_CIS_up", "toxcast-APR_HepG2_MitoMass_24h_up", "toxcast-TOX21_p53_BLA_p1_ch2", "toxcast-BSK_CASM3C_SAA_down", "toxcast-NVS_ENZ_hAurA", "toxcast-BSK_SAg_Eselectin_down", "toxcast-BSK_CASM3C_Proliferation_down", "toxcast-NVS_ENZ_hPDE4A1", "toxcast-APR_Hepat_NuclearSize_24hr_dn", "toxcast-BSK_CASM3C_MCSF_down", "toxcast-NVS_ENZ_hVEGFR2", "toxcast-CEETOX_H295R_ANDR_dn", "toxcast-NVS_GPCR_rabPAF", "toxcast-NVS_ENZ_hPI3Ka", "toxcast-ATG_AR_TRANS_up", "toxcast-ATG_NRF2_ARE_CIS_up", "toxcast-ATG_Pax6_CIS_up", "toxcast-APR_HepG2_MitoMass_24h_dn", "toxcast-ATG_HSE_CIS_dn", "clintox", "toxcast-ATG_CAR_TRANS_up", "toxcast-NVS_ENZ_rabI2C", "toxcast-NVS_GPCR_rNK3", "toxcast-TOX21_p53_BLA_p3_ch1", "toxcast-ATG_GLI_CIS_up", "toxcast-TOX21_ESRE_BLA_ch2", "toxcast-ATG_VDR_TRANS_dn", "toxcast-ATG_RORg_TRANS_dn", "tox21-SR-p53", "toxcast-BSK_CASM3C_MCSF_up", "toxcast-NVS_ENZ_hMMP2", "toxcast-APR_Hepat_DNATexture_48hr_up", "toxcast-ATG_SREBP_CIS_dn", "toxcast-BSK_LPS_MCSF_down", "toxcast-ATG_RORb_TRANS_dn", "toxcast-ATG_LXRa_TRANS_up", "toxcast-TOX21_p53_BLA_p4_ch1", "toxcast-APR_HepG2_MitoMass_72h_dn", "toxcast-OT_ERa_EREGFP_0120", "toxcast-TOX21_p53_BLA_p4_viability", "toxcast-ATG_FoxO_CIS_dn", "toxcast-BSK_3C_TissueFactor_up", "toxcast-APR_Hepat_DNADamage_48hr_up", "toxcast-ATG_M_32_TRANS_dn", "toxcast-TOX21_PPARd_BLA_agonist_ch1", "toxcast-TOX21_p53_BLA_p1_ch1", "toxcast-NVS_GPCR_rAdra1_NonSelective", "toxcast-ATG_STAT3_CIS_dn", "tox21-SR-ARE", "toxcast-TOX21_ESRE_BLA_viability", "toxcast-BSK_CASM3C_Proliferation_up", "toxcast-ATG_IR1_CIS_up", "toxcast-NVS_GPCR_gH2", "toxcast-BSK_CASM3C_VCAM1_down", "toxcast-TOX21_AR_BLA_Antagonist_viability", "toxcast-BSK_3C_HLADR_down", "toxcast-BSK_BE3C_MMP1_down", "toxcast-BSK_LPS_Eselectin_down", "toxcast-Tanguay_ZF_120hpf_JAW_up", "toxcast-BSK_BE3C_MIG_down", "toxcast-BSK_KF3CT_TIMP2_down", "herg_central-hERG_inhib", "toxcast-ATG_Oct_MLP_CIS_dn", "toxcast-TOX21_PPARg_BLA_antagonist_ratio", "toxcast-APR_Hepat_Steatosis_48hr_up", "toxcast-NVS_ENZ_hPDE10", "herg", "toxcast-ATG_TAL_CIS_up", "toxcast-NVS_GPCR_p5HT2C", "toxcast-ATG_PPARa_TRANS_up", "toxcast-NVS_NR_hTRa_Antagonist", "toxcast-TOX21_AhR_LUC_Agonist", "toxcast-TOX21_FXR_BLA_antagonist_viability", "toxcast-BSK_3C_SRB_down", "tox21-SR-MMP", "toxcast-APR_Hepat_MitoFxnI_48hr_dn", "toxcast-NVS_NR_hFXR_Agonist", "toxcast-NVS_NR_hPPARa", "toxcast-APR_HepG2_StressKinase_24h_up", "toxcast-TOX21_ERa_BLA_Antagonist_viability", "toxcast-NVS_ADME_hCYP3A4", "toxcast-CEETOX_H295R_DOC_up", "toxcast-BSK_CASM3C_uPAR_up", "toxcast-BSK_BE3C_IP10_down", "toxcast-OT_AR_ARSRC1_0480", "toxcast-CEETOX_H295R_11DCORT_dn", "toxcast-Tanguay_ZF_120hpf_AXIS_up", "toxcast-NVS_GPCR_gLTD4", "toxcast-ATG_CRE_CIS_up", "toxcast-TOX21_p53_BLA_p5_ch1", "tox21-NR-AR", "toxcast-ATG_TAL_CIS_dn", "toxcast-TOX21_p53_BLA_p2_ch1", "toxcast-ATG_PXRE_CIS_up", "toxcast-NVS_ENZ_oCOX1", "toxcast-ATG_BRE_CIS_up", "toxcast-ATG_PPRE_CIS_up", "toxcast-NVS_GPCR_rTRH", "toxcast-ATG_C_EBP_CIS_up", "toxcast-NVS_GPCR_rV1", "toxcast-BSK_KF3CT_IP10_up", "toxcast-ATG_RORg_TRANS_up", "toxcast-NCCT_TPO_GUA_dn", "toxcast-ATG_Myb_CIS_up", "toxcast-ATG_Myc_CIS_dn", "toxcast-TOX21_PPARg_BLA_Antagonist_ch1", "toxcast-NVS_ENZ_rAChE", "tox21-SR-HSE", "toxcast-ATG_LXRb_TRANS_up", "toxcast-BSK_hDFCGF_MMP1_up", "toxcast-NVS_LGIC_rGABAR_NonSelective", "toxcast-TOX21_FXR_BLA_antagonist_ratio", "toxcast-ATG_RARa_TRANS_dn", "toxcast-BSK_SAg_IL8_down", "toxcast-NVS_ENZ_hBACE", "toxcast-CEETOX_H295R_ESTRONE_dn", "ames", "toxcast-APR_HepG2_MicrotubuleCSK_24h_up", "toxcast-ATG_FoxA2_CIS_dn", "toxcast-NVS_TR_hNET", "toxcast-ATG_AP_1_CIS_dn", "toxcast-ATG_CMV_CIS_up", "toxcast-ATG_p53_CIS_up", "toxcast-ATG_PPRE_CIS_dn", "toxcast-BSK_LPS_SRB_down", "toxcast-TOX21_p53_BLA_p4_ratio", "toxcast-BSK_3C_MCP1_down", "toxcast-Tanguay_ZF_120hpf_CIRC_up", "toxcast-BSK_3C_Thrombomodulin_up", "toxcast-BSK_CASM3C_LDLR_up", "toxcast-NVS_IC_rCaDHPRCh_L", "toxcast-TOX21_p53_BLA_p2_viability", "toxcast-Tanguay_ZF_120hpf_OTIC_up", "toxcast-TOX21_GR_BLA_Agonist_ch1", "toxcast-CEETOX_H295R_TESTO_dn", "toxcast-NVS_ENZ_hMMP7", "toxcast-BSK_KF3CT_MMP9_down", "toxcast-TOX21_HSE_BLA_agonist_ratio", "toxcast-BSK_LPS_MCP1_down", "toxcast-BSK_LPS_VCAM1_down", "toxcast-TOX21_TR_LUC_GH3_Agonist", "toxcast-NVS_GPCR_hAdra2C", "toxcast-NVS_GPCR_hAdra2A", "toxcast-NVS_ENZ_hMMP9", "toxcast-TOX21_ERa_BLA_Antagonist_ch1", "toxcast-ATG_AR_TRANS_dn", "toxcast-BSK_4H_Pselectin_down", "toxcast-BSK_hDFCGF_CollagenIII_down", "toxcast-BSK_hDFCGF_TIMP1_down", "toxcast-ATG_RXRb_TRANS_up", "toxcast-TOX21_GR_BLA_Antagonist_ch2", "toxcast-BSK_LPS_PGE2_down", "toxcast-ATG_p53_CIS_dn", "toxcast-BSK_CASM3C_uPAR_down", "toxcast-NVS_IC_rCaBTZCHL", "toxcast-TOX21_AutoFluor_HEK293_Cell_blue", "toxcast-BSK_BE3C_MMP1_up", "toxcast-TOX21_ARE_BLA_agonist_viability", "toxcast-ATG_RARb_TRANS_up", "toxcast-TOX21_ESRE_BLA_ratio", "toxcast-ATG_E_Box_CIS_up", "toxcast-TOX21_AR_LUC_MDAKB2_Antagonist2", "toxcast-NVS_ENZ_rMAOBP", "toxcast-NCCT_TPO_AUR_dn", "toxcast-APR_HepG2_StressKinase_72h_up", "toxcast-TOX21_p53_BLA_p2_ch2", "toxcast-ATG_TGFb_CIS_dn", "toxcast-TOX21_PPARd_BLA_Antagonist_ch1", "toxcast-TOX21_ERa_BLA_Agonist_ch1", "toxcast-ATG_PPARa_TRANS_dn", "toxcast-ATG_M_19_CIS_dn", "toxcast-Tanguay_ZF_120hpf_ActivityScore", "toxcast-BSK_LPS_TNFa_down", "toxcast-ATG_M_32_TRANS_up", "toxcast-BSK_BE3C_TGFb1_down", "toxcast-NVS_ENZ_hAChE", "toxcast-ATG_Ets_CIS_dn", "toxcast-TOX21_ELG1_LUC_Agonist", "toxcast-ATG_Ets_CIS_up", "toxcast-BSK_LPS_PGE2_up", "toxcast-TOX21_p53_BLA_p1_viability", "toxcast-APR_HepG2_CellLoss_24h_dn", "toxcast-CLD_CYP1A1_24hr", "toxcast-ATG_NFI_CIS_up", "toxcast-CLD_CYP3A4_6hr", "toxcast-ATG_NF_kB_CIS_dn", "toxcast-BSK_hDFCGF_EGFR_up", "toxcast-APR_Hepat_Apoptosis_24hr_up", "toxcast-ATG_ERE_CIS_dn", "toxcast-ATG_ISRE_CIS_up", "toxcast-NVS_GPCR_bAdoR_NonSelective", "toxcast-NVS_NR_cAR", "toxcast-APR_Hepat_CellLoss_24hr_dn", "toxcast-TOX21_PPARd_BLA_agonist_ch2", "toxcast-ATG_E2F_CIS_up", "toxcast-Tanguay_ZF_120hpf_SNOU_up", "toxcast-CLD_CYP3A4_24hr", "toxcast-NVS_GPCR_h5HT6", "toxcast-ATG_GATA_CIS_up", "toxcast-ATG_TCF_b_cat_CIS_dn", "toxcast-TOX21_GR_BLA_Agonist_ratio", "toxcast-BSK_SAg_SRB_down", "toxcast-ACEA_T47D_80hr_Positive", "toxcast-NVS_ENZ_hCASP5", "toxcast-Tanguay_ZF_120hpf_SWIM_up", "toxcast-ATG_PXR_TRANS_dn", "toxcast-NVS_GPCR_rOpiate_NonSelective", "toxcast-NVS_ADME_hCYP4F12", "toxcast-ATG_ERa_TRANS_up", "toxcast-ATG_FoxA2_CIS_up", "toxcast-BSK_3C_uPAR_down", "tox21-NR-PPAR-gamma", "toxcast-NVS_ENZ_rMAOBC", "toxcast-ATG_AP_2_CIS_dn", "toxcast-ATG_TA_CIS_dn", "toxcast-BSK_BE3C_tPA_down", "toxcast-NVS_NR_hPXR", "toxcast-NVS_TR_hSERT", "toxcast-TOX21_HSE_BLA_agonist_ch1", "toxcast-OT_ER_ERaERa_0480", "toxcast-ATG_CMV_CIS_dn", "toxcast-ATG_ERRg_TRANS_dn", "toxcast-NVS_GPCR_hAdrb1", "toxcast-BSK_hDFCGF_SRB_down", "toxcast-Tanguay_ZF_120hpf_BRAI_up", "toxcast-TOX21_p53_BLA_p3_ratio", "toxcast-ATG_NFI_CIS_dn", "toxcast-BSK_SAg_MCP1_down", "toxcast-BSK_SAg_CD38_down", "toxcast-NVS_ENZ_rMAOAP", "toxcast-TOX21_ESRE_BLA_ch1", "toxcast-NVS_ENZ_rMAOAC", "toxcast-ATG_Ahr_CIS_up", "toxcast-ATG_LXRa_TRANS_dn", "toxcast-ATG_GR_TRANS_dn", "toxcast-NVS_GPCR_h5HT5A", "toxcast-NVS_ADME_hCYP2D6", "toxcast-TOX21_AutoFluor_HEK293_Media_blue", "toxcast-BSK_BE3C_SRB_down", "toxcast-CLD_CYP2B6_48hr", "toxcast-NVS_TR_hDAT", "toxcast-BSK_BE3C_IL1a_down", "tox21-SR-ATAD5", "toxcast-NVS_ENZ_hMMP3", "toxcast-NVS_TR_hAdoT", "toxcast-BSK_CASM3C_TissueFactor_down", "toxcast-APR_HepG2_NuclearSize_24h_dn", "toxcast-TOX21_VDR_BLA_Agonist_viability", "toxcast-APR_HepG2_MitoMembPot_24h_dn", "toxcast-BSK_4H_Pselectin_up", "toxcast-ATG_NF_kB_CIS_up", "toxcast-CEETOX_H295R_ESTRADIOL_dn", "toxcast-NVS_NR_hCAR_Antagonist", "toxcast-BSK_LPS_CD40_down", "toxcast-NHEERL_ZF_144hpf_TERATOSCORE_up", "toxcast-NVS_ENZ_hMMP1", "toxcast-NVS_TR_rNET", "toxcast-NVS_IC_rNaCh_site2", "toxcast-ATG_NURR1_TRANS_up", "toxcast-APR_Hepat_Apoptosis_48hr_up", "toxcast-TOX21_ARE_BLA_Agonist_ch2", "toxcast-OT_ER_ERbERb_1440", "toxcast-ATG_Ahr_CIS_dn", "toxcast-ATG_TCF_b_cat_CIS_up", "toxcast-ATG_DR4_LXR_CIS_dn", "toxcast-BSK_SAg_PBMCCytotoxicity_up", "toxcast-NVS_TR_rSERT", "toxcast-TOX21_MMP_ratio_down", "toxcast-ATG_Sox_CIS_dn", "toxcast-TOX21_NFkB_BLA_agonist_ch1", "toxcast-NVS_NR_hGR", "toxcast-NVS_GPCR_hLTB4_BLT1", "toxcast-BSK_4H_uPAR_down", "toxcast-ATG_IR1_CIS_dn", "toxcast-OT_NURR1_NURR1RXRa_1440", "toxcast-BSK_3C_Proliferation_down", "toxcast-NVS_ENZ_hAMPKa1", "toxcast-ATG_GRE_CIS_dn", "toxcast-BSK_hDFCGF_VCAM1_down", "toxcast-BSK_SAg_IL8_up", "toxcast-ATG_XTT_Cytotoxicity_up", "toxcast-CEETOX_H295R_ESTRONE_up", "toxcast-ATG_DR5_CIS_dn", "toxcast-BSK_hDFCGF_Proliferation_down", "toxcast-TOX21_p53_BLA_p3_viability", "toxcast-BSK_3C_IL8_down", "toxcast-BSK_LPS_IL8_down", "toxcast-NVS_ENZ_hSIRT2", "toxcast-TOX21_ERa_LUC_BG1_Agonist", "toxcast-BSK_BE3C_HLADR_down", "toxcast-NVS_GPCR_hH1", "toxcast-ATG_RARg_TRANS_up", "toxcast-Tanguay_ZF_120hpf_PE_up", "toxcast-NVS_ENZ_hPTPRC", "toxcast-NVS_GPCR_hM1", "toxcast-ATG_VDRE_CIS_dn", "toxcast-NVS_NR_hPR", "toxcast-BSK_4H_VCAM1_down", "toxcast-CLD_CYP2B6_6hr", "toxcast-Tanguay_ZF_120hpf_YSE_up", "toxcast-CEETOX_H295R_ESTRADIOL_up", "toxcast-ATG_M_32_CIS_dn", "toxcast-BSK_BE3C_uPAR_down", "toxcast-TOX21_AR_BLA_Agonist_ratio", "carcinogens_lagunin", "toxcast-ATG_NRF1_CIS_dn", "toxcast-ATG_HSE_CIS_up", "toxcast-BSK_KF3CT_ICAM1_down", "toxcast-BSK_LPS_Eselectin_up", "toxcast-ATG_Oct_MLP_CIS_up", "toxcast-ATG_GATA_CIS_dn", "toxcast-APR_HepG2_MitoMembPot_72h_dn", "tox21-NR-Aromatase", "toxcast-NVS_TR_gDAT", "toxcast-BSK_CASM3C_MCP1_down", "toxcast-BSK_SAg_PBMCCytotoxicity_down", "toxcast-NVS_GPCR_hTXA2", "toxcast-ATG_PBREM_CIS_up", "toxcast-Tanguay_ZF_120hpf_TR_up", "toxcast-ACEA_T47D_80hr_Negative", "toxcast-NVS_GPCR_hM4", "toxcast-ATG_GLI_CIS_dn", "toxcast-NVS_ENZ_hDUSP3", "toxcast-TOX21_AR_BLA_Antagonist_ch2", "toxcast-BSK_CASM3C_MCP1_up", "toxcast-ATG_NRF1_CIS_up", "toxcast-NVS_GPCR_rAdra1B", "toxcast-TOX21_VDR_BLA_antagonist_ratio", "toxcast-BSK_BE3C_PAI1_down", "toxcast-BSK_LPS_TissueFactor_down", "toxcast-NVS_ENZ_hTrkA", "herg_central-hERG_at_10uM", "toxcast-BSK_LPS_TissueFactor_up", "toxcast-Tanguay_ZF_120hpf_SOMI_up", "toxcast-NVS_GPCR_hAdrb2", "toxcast-BSK_hDFCGF_MCSF_down", "toxcast-NVS_ADME_hCYP2C19", "toxcast-OT_ER_ERaERb_1440", "toxcast-CLD_SULT2A_48hr", "toxcast-ATG_Xbp1_CIS_up", "toxcast-OT_ER_ERaERb_0480", "toxcast-CLD_UGT1A1_24hr", "toxcast-NVS_ENZ_hPTPN13", "tox21-NR-ER", "toxcast-TOX21_PPARd_BLA_Agonist_viability", "toxcast-ATG_PPARd_TRANS_up", "toxcast-CLD_ABCB1_48hr", "toxcast-ATG_PBREM_CIS_dn", "toxcast-BSK_CASM3C_IL6_up", "toxcast-ATG_GR_TRANS_up", "toxcast-NVS_GPCR_gMPeripheral_NonSelective", "toxcast-NVS_GPCR_hM2", "toxcast-ATG_DR4_LXR_CIS_up", "toxcast-APR_HepG2_MitoMembPot_1h_dn", "toxcast-NVS_ENZ_hSIRT1", "toxcast-ATG_FoxO_CIS_up", "toxcast-NVS_LGIC_hNNR_NBungSens", "toxcast-BSK_4H_Eotaxin3_down", "toxcast-ATG_CRE_CIS_dn", "toxcast-CLD_CYP1A2_48hr", "toxcast-ATG_Myc_CIS_up", "toxcast-ATG_TGFb_CIS_up", "toxcast-NVS_GPCR_hAT1", "toxcast-NVS_ENZ_hCK1D", "toxcast-TOX21_FXR_BLA_agonist_ratio", "toxcast-BSK_BE3C_uPA_down", "toxcast-APR_Hepat_Steatosis_24hr_up", "toxcast-ATG_PXR_TRANS_up", "toxcast-APR_HepG2_MitoMass_72h_up", "toxcast-NVS_ENZ_hFGFR1", "toxcast-ATG_M_19_TRANS_up", "toxcast-TOX21_FXR_BLA_agonist_ch2", "toxcast-ATG_Sp1_CIS_dn", "toxcast-BSK_KF3CT_IL1a_down", "toxcast-BSK_hDFCGF_MMP1_down", "toxcast-TOX21_PPARg_BLA_Agonist_ratio", "toxcast-NVS_GPCR_gLTB4", "toxcast-TOX21_TR_LUC_GH3_Antagonist", "dili", "toxcast-TOX21_PPARd_BLA_antagonist_ratio", "toxcast-NVS_GPCR_hOpiate_mu", "toxcast-BSK_CASM3C_Thrombomodulin_down", "toxcast-ATG_LXRb_TRANS_dn", "toxcast-APR_Hepat_NuclearSize_48hr_dn", "toxcast-TOX21_ERa_LUC_BG1_Antagonist", "toxcast-ATG_M_61_TRANS_up", "toxcast-TOX21_AutoFluor_HEPG2_Media_green", "toxcast-APR_HepG2_CellCycleArrest_72h_dn", "toxcast-BSK_3C_Eselectin_down", "toxcast-BSK_SAg_Eselectin_up", "toxcast-OT_AR_ARSRC1_0960", "toxcast-BSK_CASM3C_IL6_down", "toxcast-TOX21_AutoFluor_HEPG2_Cell_blue", "toxcast-TOX21_p53_BLA_p5_ratio", "toxcast-TOX21_AR_BLA_Agonist_ch1", "toxcast-BSK_BE3C_uPAR_up", "toxcast-NVS_ADME_hCYP1A2", "toxcast-NVS_ADME_rCYP2C12", "toxcast-APR_HepG2_CellCycleArrest_24h_up", "toxcast-ATG_C_EBP_CIS_dn", "toxcast-NVS_GPCR_rNK1", "toxcast-NVS_NR_bER", "toxcast-NVS_NR_hRAR_Antagonist", "toxcast-ATG_HNF4a_TRANS_dn", "toxcast-CEETOX_H295R_OHPREG_up", "toxcast-BSK_hDFCGF_IP10_down", "toxcast-ATG_Sp1_CIS_up", "toxcast-NVS_NR_bPR", "toxcast-CEETOX_H295R_DOC_dn", "toxcast-NVS_ENZ_hES", "toxcast-BSK_CASM3C_VCAM1_up", "toxcast-ATG_ERE_CIS_up", "toxcast-CLD_SULT2A_24hr", "toxcast-BSK_4H_uPAR_up", "tox21-NR-AhR", "toxcast-BSK_4H_MCP1_down", "toxcast-TOX21_ERa_BLA_Antagonist_ratio", "toxcast-TOX21_AutoFluor_HEPG2_Cell_green", "toxcast-NVS_GPCR_r5HT_NonSelective", "toxcast-NVS_NR_hFXR_Antagonist", "toxcast-ATG_RXRb_TRANS_dn", "toxcast-NVS_LGIC_bGABARa1", "toxcast-TOX21_p53_BLA_p4_ch2", "toxcast-BSK_hDFCGF_IL8_down", "toxcast-ATG_ISRE_CIS_dn", "toxcast-CLD_CYP3A4_48hr", "toxcast-BSK_4H_VEGFRII_down", "toxcast-ATG_AP_1_CIS_up", "toxcast-NVS_NR_rAR", "toxcast-BSK_3C_MIG_down", "toxcast-TOX21_FXR_BLA_Antagonist_ch2", "toxcast-APR_Hepat_DNATexture_24hr_up", "toxcast-BSK_SAg_Proliferation_down", "toxcast-ATG_CAR_TRANS_dn", "toxcast-CEETOX_H295R_OHPROG_up", "toxcast-APR_HepG2_MicrotubuleCSK_24h_dn", "toxcast-CLD_CYP2B6_24hr", "toxcast-BSK_CASM3C_IL8_down", "toxcast-TOX21_MMP_ratio_up", "toxcast-NVS_GPCR_h5HT2A", "toxcast-NVS_GPCR_bDR_NonSelective", "toxcast-NVS_ENZ_hMMP13", "toxcast-TOX21_AR_LUC_MDAKB2_Antagonist", "toxcast-TOX21_GR_BLA_Agonist_ch2", "toxcast-ATG_M_19_TRANS_dn", "toxcast-CEETOX_H295R_CORTISOL_dn", "toxcast-OT_AR_ARELUC_AG_1440", "toxcast-TOX21_VDR_BLA_Antagonist_ch1", "toxcast-ATG_Myb_CIS_dn", "toxcast-ATG_BRE_CIS_dn", "ld50_zhu", "toxcast-NVS_NR_hAR", "toxcast-ATG_ERRg_TRANS_up", "toxcast-NCCT_QuantiLum_inhib_dn", "toxcast-ATG_STAT3_CIS_up", "toxcast-TOX21_ARE_BLA_Agonist_ch1", "toxcast-CLD_CYP1A2_6hr", "toxcast-BSK_KF3CT_MCP1_up", "toxcast-NVS_GPCR_hM3", "toxcast-NVS_OR_gSIGMA_NonSelective", "toxcast-ATG_DR5_CIS_up", "toxcast-NVS_ADME_hCYP1A1", "toxcast-BSK_SAg_CD69_down", "toxcast-APR_HepG2_NuclearSize_72h_up", "toxcast-CLD_ABCG2_48hr", "toxcast-NVS_GPCR_gOpiateK", "toxcast-ATG_AP_2_CIS_up", "toxcast-NVS_ENZ_hPTPN9", "toxcast-APR_Hepat_CellLoss_48hr_dn", "toxcast-OT_ERa_EREGFP_0480", "toxcast-NVS_NR_hRARa_Agonist", "toxcast-BSK_CASM3C_Thrombomodulin_up", "toxcast-NVS_ENZ_hPTEN", "toxcast-NVS_ADME_hCYP2B6", "toxcast-TOX21_VDR_BLA_agonist_ratio", "toxcast-NVS_ENZ_hPDE5", "toxcast-NVS_NR_hPPARg", "toxcast-NVS_ENZ_rCNOS", "toxcast-BSK_LPS_IL1a_down", "toxcast-BSK_CASM3C_LDLR_down", "toxcast-ATG_HNF6_CIS_up", "toxcast-TOX21_AutoFluor_HEPG2_Media_blue", "toxcast-BSK_hDFCGF_EGFR_down", "toxcast-TOX21_AR_BLA_Agonist_ch2", "toxcast-TOX21_FXR_BLA_Antagonist_ch1", "toxcast-ATG_PXRE_CIS_dn", "toxcast-BSK_SAg_CD40_down" ], "metabolism": [ "cyp3a4_substrate_carbonmangels", "cyp3a4_veith", "cyp2c19_veith", "cyp2c9_substrate_carbonmangels", "cyp2d6_substrate_carbonmangels", "cyp1a2_veith", "cyp2c9_veith", "cyp2d6_veith" ], "absorption": [ "lipophilicity_astrazeneca", "pgp_broccatelli", "bioavailability_ma", "hia_hou", "pampa_ncats", "caco2_wang", "hydrationfreeenergy_freesolv", "solubility_aqsoldb" ], "excretion": [ "half_life_obach", "clearance_microsome_az", "clearance_hepatocyte_az" ], "distribution": [ "bbb_martins", "ppbr_az", "vdss_lombardo" ] }