{
  "biomarkers": {
    "Glucose": {
      "unit": "mg/dL",
      "normal_range": {"min": 70, "max": 100},
      "critical_low": 54,
      "critical_high": 400,
      "type": "fasting",
      "gender_specific": false,
      "description": "Fasting blood glucose level",
      "clinical_significance": {
        "low": "Hypoglycemia - risk of confusion, seizures",
        "high": "Hyperglycemia - diabetes risk, requires further testing"
      }
    },
    "Cholesterol": {
      "unit": "mg/dL",
      "normal_range": {"min": 125, "max": 200},
      "critical_low": 100,
      "critical_high": 240,
      "type": "total",
      "gender_specific": false,
      "description": "Total cholesterol level",
      "clinical_significance": {
        "low": "Malnutrition, liver disease, or hyperthyroidism",
        "high": "Increased cardiovascular disease risk"
      }
    },
    "Hemoglobin": {
      "unit": "g/dL",
      "normal_range": {
        "male": {"min": 13.5, "max": 17.5},
        "female": {"min": 12.0, "max": 15.5}
      },
      "critical_low": 7,
      "critical_high": 18,
      "gender_specific": true,
      "description": "Oxygen-carrying protein in red blood cells",
      "clinical_significance": {
        "low": "Anemia - fatigue, weakness, organ hypoxia",
        "high": "Polycythemia - increased blood viscosity, clotting risk"
      }
    },
    "Platelets": {
      "unit": "cells/μL",
      "normal_range": {"min": 150000, "max": 400000},
      "critical_low": 50000,
      "critical_high": 1000000,
      "gender_specific": false,
      "description": "Blood clotting cells",
      "clinical_significance": {
        "low": "Thrombocytopenia - bleeding risk",
        "high": "Thrombocytosis - clotting risk"
      }
    },
    "White Blood Cells": {
      "unit": "cells/μL",
      "normal_range": {"min": 4000, "max": 11000},
      "critical_low": 2000,
      "critical_high": 30000,
      "gender_specific": false,
      "description": "Immune system cells",
      "clinical_significance": {
        "low": "Leukopenia - infection risk",
        "high": "Leukocytosis - infection or leukemia"
      }
    },
    "Red Blood Cells": {
      "unit": "million/μL",
      "normal_range": {
        "male": {"min": 4.5, "max": 5.9},
        "female": {"min": 4.0, "max": 5.2}
      },
      "critical_low": 3.0,
      "critical_high": null,
      "gender_specific": true,
      "description": "Oxygen-carrying blood cells",
      "clinical_significance": {
        "low": "Severe anemia - organ damage risk"
      }
    },
    "Hematocrit": {
      "unit": "%",
      "normal_range": {
        "male": {"min": 38.8, "max": 50.0},
        "female": {"min": 34.9, "max": 44.5}
      },
      "critical_low": 25,
      "critical_high": 60,
      "gender_specific": true,
      "description": "Percentage of blood volume occupied by red blood cells",
      "clinical_significance": {
        "low": "Severe anemia",
        "high": "Polycythemia - stroke risk"
      }
    },
    "Mean Corpuscular Volume": {
      "unit": "fL",
      "normal_range": {"min": 80, "max": 100},
      "critical_low": null,
      "critical_high": null,
      "gender_specific": false,
      "description": "Average red blood cell size",
      "clinical_significance": {
        "low": "Microcytic anemia (iron deficiency, thalassemia)",
        "high": "Macrocytic anemia (B12/folate deficiency)"
      }
    },
    "Mean Corpuscular Hemoglobin": {
      "unit": "pg",
      "normal_range": {"min": 27, "max": 33},
      "critical_low": null,
      "critical_high": null,
      "gender_specific": false,
      "description": "Average hemoglobin per red blood cell",
      "clinical_significance": {
        "low": "Hypochromic anemia"
      }
    },
    "Mean Corpuscular Hemoglobin Concentration": {
      "unit": "g/dL",
      "normal_range": {"min": 32, "max": 36},
      "critical_low": null,
      "critical_high": null,
      "gender_specific": false,
      "description": "Average hemoglobin concentration in red blood cells",
      "clinical_significance": {
        "low": "Hypochromic anemia"
      }
    },
    "Insulin": {
      "unit": "μIU/mL",
      "normal_range": {"min": 2.6, "max": 24.9},
      "critical_low": null,
      "critical_high": 25,
      "type": "fasting",
      "gender_specific": false,
      "description": "Fasting insulin level",
      "clinical_significance": {
        "high": "Insulin resistance - diabetes/metabolic syndrome risk"
      }
    },
    "BMI": {
      "unit": "kg/m²",
      "normal_range": {"min": 18.5, "max": 24.9},
      "critical_low": 15,
      "critical_high": 50,
      "gender_specific": false,
      "description": "Body Mass Index",
      "clinical_significance": {
        "low": "Underweight - malnutrition risk",
        "high": "Obese - cardiovascular and metabolic disease risk"
      }
    },
    "Systolic Blood Pressure": {
      "unit": "mmHg",
      "normal_range": {"min": 90, "max": 120},
      "critical_low": 70,
      "critical_high": 180,
      "gender_specific": false,
      "description": "Blood pressure during heart contraction",
      "clinical_significance": {
        "low": "Hypotension - dizziness, fainting",
        "high": "Hypertension - cardiovascular disease risk"
      }
    },
    "Diastolic Blood Pressure": {
      "unit": "mmHg",
      "normal_range": {"min": 60, "max": 80},
      "critical_low": 40,
      "critical_high": 120,
      "gender_specific": false,
      "description": "Blood pressure during heart relaxation",
      "clinical_significance": {
        "low": "Hypotension",
        "high": "Hypertension"
      }
    },
    "Triglycerides": {
      "unit": "mg/dL",
      "normal_range": {"min": 40, "max": 150},
      "critical_low": null,
      "critical_high": 500,
      "gender_specific": false,
      "description": "Type of blood fat",
      "clinical_significance": {
        "high": "Pancreatitis risk, cardiovascular disease"
      }
    },
    "HbA1c": {
      "unit": "%",
      "normal_range": {"min": 4.0, "max": 5.7},
      "critical_low": null,
      "critical_high": 14,
      "gender_specific": false,
      "description": "3-month average blood glucose",
      "clinical_significance": {
        "high": "Diabetes (≥6.5%), Prediabetes (5.7-6.4%)"
      }
    },
    "LDL Cholesterol": {
      "unit": "mg/dL",
      "normal_range": {"min": 40, "max": 100},
      "critical_low": null,
      "critical_high": 190,
      "gender_specific": false,
      "description": "Low-density lipoprotein (bad cholesterol)",
      "clinical_significance": {
        "high": "Atherosclerosis, heart disease risk"
      }
    },
    "HDL Cholesterol": {
      "unit": "mg/dL",
      "normal_range": {
        "male": {"min": 40, "max": 100},
        "female": {"min": 50, "max": 100}
      },
      "critical_low": 25,
      "critical_high": null,
      "gender_specific": true,
      "description": "High-density lipoprotein (good cholesterol)",
      "clinical_significance": {
        "low": "Cardiovascular disease risk"
      }
    },
    "ALT": {
      "unit": "U/L",
      "normal_range": {"min": 7, "max": 56},
      "critical_low": null,
      "critical_high": 200,
      "gender_specific": false,
      "description": "Alanine aminotransferase (liver enzyme)",
      "clinical_significance": {
        "high": "Liver damage or disease"
      }
    },
    "AST": {
      "unit": "U/L",
      "normal_range": {"min": 10, "max": 40},
      "critical_low": null,
      "critical_high": 200,
      "gender_specific": false,
      "description": "Aspartate aminotransferase (liver/heart enzyme)",
      "clinical_significance": {
        "high": "Liver or heart damage"
      }
    },
    "Heart Rate": {
      "unit": "bpm",
      "normal_range": {"min": 60, "max": 100},
      "critical_low": 50,
      "critical_high": 120,
      "gender_specific": false,
      "description": "Beats per minute",
      "clinical_significance": {
        "low": "Bradycardia - dizziness, fatigue",
        "high": "Tachycardia - palpitations, anxiety"
      }
    },
    "Creatinine": {
      "unit": "mg/dL",
      "normal_range": {
        "male": {"min": 0.7, "max": 1.3},
        "female": {"min": 0.6, "max": 1.1}
      },
      "critical_low": null,
      "critical_high": 3.0,
      "gender_specific": true,
      "description": "Kidney function marker",
      "clinical_significance": {
        "high": "Kidney dysfunction or failure"
      }
    },
    "Troponin": {
      "unit": "ng/mL",
      "normal_range": {"min": 0, "max": 0.04},
      "critical_low": null,
      "critical_high": 0.4,
      "gender_specific": false,
      "description": "Cardiac muscle damage marker",
      "clinical_significance": {
        "high": "Myocardial injury or infarction (heart attack)"
      }
    },
    "C-reactive Protein": {
      "unit": "mg/L",
      "normal_range": {"min": 0, "max": 3.0},
      "critical_low": null,
      "critical_high": 10,
      "gender_specific": false,
      "description": "Inflammation marker",
      "clinical_significance": {
        "high": "Acute inflammation or infection"
      }
    },
    "Urea": {
      "unit": "mg/dL",
      "normal_range": {"min": 7, "max": 20},
      "critical_low": null,
      "critical_high": 50,
      "gender_specific": false,
      "description": "Blood urea nitrogen (kidney function marker)",
      "clinical_significance": {
        "high": "Kidney dysfunction, dehydration, or high-protein diet",
        "low": "Liver disease or malnutrition"
      }
    },
    "TSH": {
      "unit": "mIU/L",
      "normal_range": {"min": 0.4, "max": 4.0},
      "critical_low": 0.1,
      "critical_high": 10,
      "gender_specific": false,
      "description": "Thyroid-stimulating hormone",
      "clinical_significance": {
        "low": "Hyperthyroidism",
        "high": "Hypothyroidism"
      }
    },
    "T3": {
      "unit": "ng/dL",
      "normal_range": {"min": 80, "max": 200},
      "critical_low": null,
      "critical_high": null,
      "gender_specific": false,
      "description": "Triiodothyronine (thyroid hormone)",
      "clinical_significance": {
        "low": "Hypothyroidism",
        "high": "Hyperthyroidism"
      }
    },
    "T4": {
      "unit": "μg/dL",
      "normal_range": {"min": 5.0, "max": 12.0},
      "critical_low": null,
      "critical_high": null,
      "gender_specific": false,
      "description": "Thyroxine (thyroid hormone)",
      "clinical_significance": {
        "low": "Hypothyroidism",
        "high": "Hyperthyroidism"
      }
    },
    "Sodium": {
      "unit": "mEq/L",
      "normal_range": {"min": 136, "max": 145},
      "critical_low": 120,
      "critical_high": 155,
      "gender_specific": false,
      "description": "Blood sodium level (electrolyte)",
      "clinical_significance": {
        "low": "Hyponatremia - confusion, seizures",
        "high": "Hypernatremia - dehydration, thirst"
      }
    },
    "Potassium": {
      "unit": "mEq/L",
      "normal_range": {"min": 3.5, "max": 5.0},
      "critical_low": 2.5,
      "critical_high": 6.5,
      "gender_specific": false,
      "description": "Blood potassium level (electrolyte)",
      "clinical_significance": {
        "low": "Hypokalemia - muscle weakness, arrhythmia",
        "high": "Hyperkalemia - cardiac arrest risk"
      }
    },
    "Calcium": {
      "unit": "mg/dL",
      "normal_range": {"min": 8.5, "max": 10.5},
      "critical_low": 7.0,
      "critical_high": 12.0,
      "gender_specific": false,
      "description": "Blood calcium level",
      "clinical_significance": {
        "low": "Hypocalcemia - muscle cramps, numbness",
        "high": "Hypercalcemia - kidney stones, bone pain"
      }
    },
    "Chloride": {
      "unit": "mEq/L",
      "normal_range": {"min": 98, "max": 106},
      "critical_low": 80,
      "critical_high": 120,
      "gender_specific": false,
      "description": "Blood chloride level (electrolyte)",
      "clinical_significance": {
        "low": "Metabolic alkalosis",
        "high": "Metabolic acidosis"
      }
    },
    "Bicarbonate": {
      "unit": "mEq/L",
      "normal_range": {"min": 22, "max": 28},
      "critical_low": 15,
      "critical_high": 35,
      "gender_specific": false,
      "description": "Blood bicarbonate (acid-base balance)",
      "clinical_significance": {
        "low": "Metabolic acidosis",
        "high": "Metabolic alkalosis"
      }
    },
    "Uric_Acid": {
      "unit": "mg/dL",
      "normal_range": {
        "male": {"min": 3.4, "max": 7.0},
        "female": {"min": 2.4, "max": 6.0}
      },
      "critical_low": null,
      "critical_high": 10,
      "gender_specific": true,
      "description": "Blood uric acid level",
      "clinical_significance": {
        "high": "Gout risk, kidney stone risk"
      }
    },
    "Total_Protein": {
      "unit": "g/dL",
      "normal_range": {"min": 6.0, "max": 8.3},
      "critical_low": 4.5,
      "critical_high": null,
      "gender_specific": false,
      "description": "Total serum protein",
      "clinical_significance": {
        "low": "Liver disease, malnutrition, kidney disease",
        "high": "Chronic inflammation, multiple myeloma"
      }
    },
    "Albumin": {
      "unit": "g/dL",
      "normal_range": {"min": 3.5, "max": 5.5},
      "critical_low": 2.0,
      "critical_high": null,
      "gender_specific": false,
      "description": "Serum albumin (liver function)",
      "clinical_significance": {
        "low": "Liver disease, malnutrition, kidney disease"
      }
    },
    "Globulin": {
      "unit": "g/dL",
      "normal_range": {"min": 2.0, "max": 3.5},
      "critical_low": null,
      "critical_high": null,
      "gender_specific": false,
      "description": "Serum globulin (immune proteins)",
      "clinical_significance": {
        "low": "Immune deficiency",
        "high": "Chronic inflammation, liver disease"
      }
    },
    "AG_Ratio": {
      "unit": "ratio",
      "normal_range": {"min": 1.1, "max": 2.5},
      "critical_low": null,
      "critical_high": null,
      "gender_specific": false,
      "description": "Albumin/Globulin ratio",
      "clinical_significance": {
        "low": "Liver disease, autoimmune conditions",
        "high": "Generally not clinically significant"
      }
    },
    "Bilirubin_Total": {
      "unit": "mg/dL",
      "normal_range": {"min": 0.1, "max": 1.2},
      "critical_low": null,
      "critical_high": 5.0,
      "gender_specific": false,
      "description": "Total bilirubin (liver function marker)",
      "clinical_significance": {
        "high": "Liver disease, bile duct obstruction, hemolysis"
      }
    },
    "ALP": {
      "unit": "U/L",
      "normal_range": {"min": 44, "max": 147},
      "critical_low": null,
      "critical_high": 500,
      "gender_specific": false,
      "description": "Alkaline phosphatase (liver/bone enzyme)",
      "clinical_significance": {
        "high": "Liver disease, bone disorders, bile duct issues"
      }
    },
    "BUN": {
      "unit": "mg/dL",
      "normal_range": {"min": 7, "max": 20},
      "critical_low": null,
      "critical_high": 50,
      "gender_specific": false,
      "description": "Blood urea nitrogen (kidney function)",
      "clinical_significance": {
        "high": "Kidney dysfunction, dehydration"
      }
    },
    "BUN_Creatinine_Ratio": {
      "unit": "ratio",
      "normal_range": {"min": 10, "max": 20},
      "critical_low": null,
      "critical_high": null,
      "gender_specific": false,
      "description": "BUN to Creatinine ratio",
      "clinical_significance": {
        "high": "Pre-renal cause (dehydration, GI bleeding)",
        "low": "Intrinsic renal disease, liver disease"
      }
    },
    "VLDL": {
      "unit": "mg/dL",
      "normal_range": {"min": 2, "max": 30},
      "critical_low": null,
      "critical_high": null,
      "gender_specific": false,
      "description": "Very low-density lipoprotein cholesterol",
      "clinical_significance": {
        "high": "Increased cardiovascular risk"
      }
    }
  }
}